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Your search keyword '"Meiqi, Wang"' showing total 259 results
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259 results on '"Meiqi, Wang"'

255. A proprietary extract from North American ginseng (Panax quinquefolium) enhances IL-2 and IFN-gamma productions in murine spleen cells induced by Con-A

Author

Yingqi Wu, Larry J. Guilbert, Jie Li, Peter K.T. Pang, Meiqi Wang, Jacqueline J. Shan, and Tapan K. Basu

Subjects
Interleukin 2, medicine.drug_class, Chemistry, Pharmaceutical, Immunology, Panax, Spleen, Mice, Inbred Strains, Immunostimulant, Plant Roots, Microbiology, Ginseng, Interferon-gamma, Mice, Immune system, Adjuvants, Immunologic, medicine, Splenocyte, Concanavalin A, Immunology and Allergy, Animals, American ginseng, Cells, Cultured, Pharmacology, Traditional medicine, biology, Dose-Response Relationship, Drug, business.industry, Plant Extracts, Reproducibility of Results, biology.organism_classification, medicine.anatomical_structure, Interleukin-2, business, Ex vivo, medicine.drug
Abstract

A patented aqueous extract from North American ginseng ( Panax quinquefolium ), containing mainly oligosaccharides and polysaccharides, is commercially available over the counter as COLD-FX (CVT-E002). This proprietary extract is used for the treatment of upper respiratory tract infections. Its in vitro stimulating effects on the immunoglobulin production by B lymphocytes and on natural immune responses by peritoneal exudates macrophages have been previously reported. Using C57 BL/6 mice, an ex vivo study was conducted to examine Con-A-induced splenocytic productions of interleukin-2 (IL-2) and interferon-gamma (IFN-γ) as markers of acquired immune responses. CVT-E002 (10–500 μg/ml) significantly increased Con-A-induced IL-2 and IFN-γ productions in spleen cells in a dose-dependent manner. Such response was seen by the ginseng extract originated from three different lots, suggesting consistency between the lots.

Published
2003

259. Peroxisome proliferator-activated receptor-γ: Master regulator of adipogenesis and obesity

Author

Meiqi Wang, Qiang Peng, Shuwen Deng, Na Fu, Ling Ye, Yunfeng Lin, Jiamin Xie, Yan Jiang, Xue-Qin Wei, and Xiaoru Shao

Subjects
0301 basic medicine, medicine.medical_specialty, Medicine (miscellaneous), Peroxisome proliferator-activated receptor, Biology, Ligands, PPAR agonist, 03 medical and health sciences, Insulin resistance, Internal medicine, Diabetes mellitus, Hyperlipidemia, medicine, Humans, Obesity, Receptor, chemistry.chemical_classification, Adipogenesis, General Medicine, Peroxisome, medicine.disease, Lipid Metabolism, PPAR gamma, 030104 developmental biology, Endocrinology, chemistry, Diabetes Mellitus, Type 2, Carbohydrate Metabolism, lipids (amino acids, peptides, and proteins), Thiazolidinediones
Abstract

Obesity, which is a key risk for the development of hyperglycemia, hypertension, hyperlipidemia and insulin resistance and is totally referred to as the metabolic disorders, has aroused people's great attention because of its alarming increase rate around the world. It is widely known that the occurrence of obesity can be attributed to both environmental and genetic factors. Peroxisome proliferators-activated receptor (PPAR), a member of ligand-dependent receptor, is one of the important genetic factors. PPAR includes three isoforms: PPAR-α, PPAR- β and PPAR- γ, all of which are exerting critical influences on the maintenance of the metabolism of saccharides, lipids and proteins. PPAR-γ is of great importance in the regulation of adipogenesis; in addition, it is essential in the prevention of adiposis and the treatment of 2-diabetes mellitus. In this review, we focus on giving a brief introduction about PPAR family, the indispensible function of PPAR-γ in adipogenesis and the inseparable relationship between PPAR-γ and obesity, deriving from the understanding of how these receptors activated will provide windows of opportunities for the treatment of obesity and associated metabolism syndromes.

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