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Introduction: Identifying the most effective ways to support career development of early stage investigators in clinical and translational science should yield benefits for the biomedical research community. Institutions with Clinical and Translational Science Awards (CTSA) offer KL2 programs to facilitate career development; however, the sustained impact has not been widely assessed. Methods: A survey comprised of quantitative and qualitative questions was sent to 2144 individuals that had previously received support through CTSA KL2 mechanisms. The 547 responses were analyzed with identifying information redacted. Results: Respondents held MD (47%), PhD (36%), and MD/PhD (13%) degrees. After KL2 support was completed, physicians' time was divided 50% to research and 30% to patient care, whereas PhD respondents devoted 70% time to research. Funded research effort averaged 60% for the cohort. Respondents were satisfied with their career progression. More than 95% thought their current job was meaningful. Two-thirds felt confident or very confident in their ability to sustain a career in clinical and translational research. Factors cited as contributing to career success included protected time, mentoring, and collaborations. Conclusion: This first large systematic survey of KL2 alumni provides valuable insight into the group's perceptions of the program and outcome information. Former scholars are largely satisfied with their career choice and direction, national recognition of their expertise, and impact of their work. Importantly, they identified training activities that contributed to success. Our results and future analysis of the survey data should inform the framework for developing platforms to launch sustaining careers of translational scientists. [ABSTRACT FROM AUTHOR]

Introduction: A national survey characterized training and career development for translational researchers through Clinical and Translational Science Award (CTSA) T32/TL1 programs. This report summarizes program goals, trainee characteristics, and mentorship practices. Methods: A web link to a voluntary survey was emailed to 51 active TL1 program directors and administrators. Descriptive analyses were performed on aggregate data. Qualitative data analysis used open coding of text followed by an axial coding strategy based on the grounded theory approach. Results: Fifty out of 51 (98%) invited CTSA hubs responded. Training program goals were aligned with the CTSA mission. The trainee population consisted of predoctoral students (50%), postdoctoral fellows (30%), and health professional students in short-term (11%) or year-out (9%) research training. Forty percent of TL1 programs support both predoctoral and postdoctoral trainees. Trainees are diverse by academic affiliation, mostly from medicine, engineering, public health, non-health sciences, pharmacy, and nursing. Mentor training is offered by most programs, but mandatory at less than one-third of them. Most mentoring teams consist of two or more mentors. Conclusions: CTSA TL1 programs are distinct from other NIH-funded training programs in their focus on clinical and translational research, cross-disciplinary approaches, emphasis on team science, and integration of multiple trainee types. Trainees in nearly all TL1 programs were engaged in all phases of translational research (preclinical, clinical, implementation, public health), suggesting that the CTSA TL1 program is meeting the mandate of NCATS to provide training to develop the clinical and translational research workforce. [ABSTRACT FROM AUTHOR]

We investigate the occurrence of the "extended solar cycle" (ESC) as it occurs in a host of observational data spanning 140 years. Investigating coronal, chromospheric, photospheric, and interior diagnostics, we develop a consistent picture of solar activity migration linked to the 22-year Hale (magnetic) cycle using superposed epoch analysis (SEA) and previously identified Hale cycle termination events as the key time for the SEA. Our analysis shows that the ESC and Hale cycle, as highlighted by the terminator-keyed SEA, is strongly recurrent throughout the entire observational record studied, some 140 years. Applying the same SEA method to the sunspot record confirms that Maunder's butterfly pattern is a subset of the underlying Hale cycle, strongly suggesting that the production of sunspots is not the fundamental feature of the Hale cycle, but the ESC is. The ESC (and Hale cycle) pattern highlights the importance of 55 ∘ latitude in the evolution, and possible production, of solar magnetism. [ABSTRACT FROM AUTHOR]

Booth (Solar Phys.296, 108, 2021; hereafter B21) is essentially a critique of the Hilbert transform techniques used in our paper (Leamon et al., Solar Phys.295, 36, 2020; hereafter L20) to predict the termination of solar cycles. Here we respond to his arguments; our methodology and parameter choices do extract a mathematically robust signature of terminators from the historical sunspot record. We agree that the attempt in L20 to extrapolate beyond the sunspot record gives a failed prediction for the next terminator of May 2020, and we identify both a possible cause and remedy here. However, we disagree with the B21 assessment that the likely termination of Solar Cycle 24 is two years after the date predicted in L20, and we show why. [ABSTRACT FROM AUTHOR]

The Interface Region Imaging Spectrograph (IRIS) has been obtaining near- and far-ultraviolet images and spectra of the solar atmosphere since July 2013. IRIS is the highest resolution observatory to provide seamless coverage of spectra and images from the photosphere into the low corona. The unique combination of near- and far-ultraviolet spectra and images at sub-arcsecond resolution and high cadence allows the tracing of mass and energy through the critical interface between the surface and the corona or solar wind. IRIS has enabled research into the fundamental physical processes thought to play a role in the low solar atmosphere such as ion–neutral interactions, magnetic reconnection, the generation, propagation, and dissipation of waves, the acceleration of non-thermal particles, and various small-scale instabilities. IRIS has provided insights into a wide range of phenomena including the discovery of non-thermal particles in coronal nano-flares, the formation and impact of spicules and other jets, resonant absorption and dissipation of Alfvénic waves, energy release and jet-like dynamics associated with braiding of magnetic-field lines, the role of turbulence and the tearing-mode instability in reconnection, the contribution of waves, turbulence, and non-thermal particles in the energy deposition during flares and smaller-scale events such as UV bursts, and the role of flux ropes and various other mechanisms in triggering and driving CMEs. IRIS observations have also been used to elucidate the physical mechanisms driving the solar irradiance that impacts Earth's upper atmosphere, and the connections between solar and stellar physics. Advances in numerical modeling, inversion codes, and machine-learning techniques have played a key role. With the advent of exciting new instrumentation both on the ground, e.g. the Daniel K. Inouye Solar Telescope (DKIST) and the Atacama Large Millimeter/submillimeter Array (ALMA), and space-based, e.g. the Parker Solar Probe and the Solar Orbiter, we aim to review new insights based on IRIS observations or related modeling, and highlight some of the outstanding challenges. [ABSTRACT FROM AUTHOR]

This document is an abstract from the Journal of Clinical & Translational Science. It includes three separate studies. The first study discusses the impact of the COVID-19 pandemic on CTSA training and career development. The second study focuses on the diversity and assets of the current workforce in D&I (Dissemination and Implementation) efforts at Frontiers CTSI. The third study explores the perceived impact of the COVID-19 pandemic on training and career development for CTSA T trainees and K scholars. Overall, the studies highlight the challenges and resilience of researchers during the pandemic and the importance of diversity and resources in research efforts. [Extracted from the article]

We study the solar wind helium-to-hydrogen abundance's ( A He ) relationship to solar cycle onset. Using OMNI/Lo data, we show that A He increases prior to sunspot number (SSN) minima. We also identify a rapid depletion and recovery in A He that occurs directly prior to cycle onset. This A He shutoff happens at approximately the same time across solar wind speeds ( v sw ) and the time between successive A He shutoffs is typically on the order of the corresponding solar cycle length. In contrast to A He 's v sw -dependent phase lag with respect to SSN (Alterman and Kasper, 2019), A He shutofff's concurrence across v sw likely implies it is independent of solar wind acceleration and driven by a mechanism near or below the photosphere. Using brightpoint (BP) measurements to provide context, we infer that A He shutoff is likely related to the overlap of adjacent solar cycles and the equatorial flux cancelation of the older, extended solar cycle during solar minima. [ABSTRACT FROM AUTHOR]