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626 results on '"Matteucci C"'

303. The beta-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line

Author

Albini, A., Paglieri, I., Orengo, G., Carlone, S., Aluigi, M.G., Demarchi, R., Matteucci, C., Mantovani, A., Carozzi, F., Donini, S., and Benelli, R.

Subjects
Kaposi's sarcoma -- Physiological aspects, Chorionic gonadotropin -- Physiological aspects -- Growth, Cancer cells -- Growth -- Physiological aspects, Health, Company growth, Physiological aspects, Growth
Abstract

Albini, A.; Paglieri, I.; Orengo, G.; Carlone, S.; Aluigi, M.G.; Demarchi, R.; Matteucci, C.; Mantovani, A.; Carozzi, F.; Donini, S.; Benelli, R. 'The Beta-Core Fragment of Human Chorionic Gonadotrophin Inhibits [...]

Published
1997

305. Distinct genomic events in the myeloid and lymphoid lineages in simultaneous presentation of chronic myeloid leukemia and B-chronic lymphocytic leukemia.

Author

Crescenzi, B, Sacchi, S, Marasca, R, Temperani, P, La Starza, R, Matteucci, C, Bonacorsi, G, Romoli, S, Martelli, M F, Mecucci, C, and Emilia, G

Subjects
MYELOID leukemia, CHRONIC lymphocytic leukemia
Abstract

Leukemia (2002) 16, 955–956. DOI: 10.1038/sj/leu/2402490 [ABSTRACT FROM AUTHOR]

Published
2002
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310. 14q32 rearrangements deregulating BCL11B mark a distinct subgroup of T-lymphoid and myeloid immature acute leukemia

Author

Jan Cools, Martina Moretti, Peter Vandenberghe, Paolo Gorello, Giovanni Roti, Renato Bassan, Giovanna De Santis, Rocco Piazza, Nicoletta Testoni, Fabrizia Pellanera, Roberta La Starza, Jean-Pierre Bourquin, Cristina Mecucci, Kim De Keersmaecker, Zeynep Kalender Atak, Christine J. Harrison, Valentina Pierini, Beat Bornhauser, Danika Di Giacomo, Caterina Matteucci, Silvia Arniani, Stein Aerts, Di Giacomo, D, La Starza, R, Gorello, P, Pellanera, F, Kalender Atak, Z, De Keersmaecker, K, Pierini, V, Harrison, C, Arniani, S, Moretti, M, Testoni, N, De Santis, G, Roti, G, Matteucci, C, Bassan, R, Vandenberghe, P, Aerts, S, Cools, J, Bornhauser, B, Bourquin, J, Piazza, R, Mecucci, C, University of Zurich, Mecucci, Cristina, Di Giacomo D., La Starza R., Gorello P., Pellanera F., Kalender Atak Z., De Keersmaecker K., Pierini V., Harrison C.J., Arniani S., Moretti M., Testoni N., De Santis G., Roti G., Matteucci C., Bassan R., Vandenberghe P., Aerts S., Cools J., Bornhauser B., Bourquin J.-P., Piazza R., and Mecucci C.

Subjects
Adult, Male, Myeloid, 1303 Biochemistry, Adolescent, BCL11B, Immunology, 2720 Hematology, Chromosomal translocation, 610 Medicine & health, Biology, Precursor T-Cell Lymphoblastic Leukemia-Lymphoma, Biochemistry, Translocation, Genetic, Fusion gene, 1307 Cell Biology, hemic and lymphatic diseases, Acute lymphocytic leukemia, medicine, Biomarkers, Tumor, Humans, Child, Aged, Chromosomes, Human, Pair 14, Acute leukemia, 2403 Immunology, Tumor Suppressor Protein, Gene Expression Regulation, Leukemic, Tumor Suppressor Proteins, Gene Expression Profiling, Myeloid leukemia, Cell Biology, Hematology, Middle Aged, Repressor Protein, medicine.disease, Repressor Proteins, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Fusion transcript, 10036 Medical Clinic, Child, Preschool, Cancer research, Female, Human
Abstract

Acute leukemias (ALs) of ambiguous lineage are a heterogeneous group of high-risk leukemias characterized by coexpression of myeloid and lymphoid markers. In this study, we identified a distinct subgroup of immature acute leukemias characterized by a broadly variable phenotype, covering acute myeloid leukemia (AML, M0 or M1), T/myeloid mixed-phenotype acute leukemia (T/M MPAL), and early T-cell precursor acute lymphoblastic leukemia (ETP-ALL). Rearrangements at 14q32/BCL11B are the cytogenetic hallmark of this entity. In our screening of 915 hematological malignancies, there were 202 AML and 333 T-cell acute lymphoblastic leukemias (T-ALL: 58, ETP; 178, non-ETP; 8, T/M MPAL; 89, not otherwise specified). We identified 20 cases of immature leukemias (4% of AML and 3.6% of T-ALL), harboring 4 types of 14q32/BCL11B translocations: t(2,14)(q22.3;q32) (n = 7), t(6;14)(q25.3;q32) (n = 9), t(7;14)(q21.2;q32) (n = 2), and t(8;14)(q24.2;q32) (n = 2). The t(2;14) produced a ZEB2-BCL11B fusion transcript, whereas the other 3 rearrangements displaced transcriptionally active enhancer sequences close to BCL11B without producing fusion genes. All translocations resulted in the activation of BCL11B, a regulator of T-cell differentiation associated with transcriptional corepressor complexes in mammalian cells. The expression of BCL11B behaved as a disease biomarker that was present at diagnosis, but not in remission. Deregulation of BCL11B co-occurred with variants at FLT3 and at epigenetic modulators, most frequently the DNMT3A, TET2, and/or WT1 genes. Transcriptome analysis identified a specific expression signature, with significant downregulation of BCL11B targets, and clearly separating BCL11B AL from AML, T-ALL, and ETP-ALL. Remarkably, an ex vivo drug-sensitivity profile identified a panel of compounds with effective antileukemic activity.

Published
2021

315. Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia.

Author

La Starza, R., Aventin, A., Matteucci, C., Crescenzi, B., Romoli, S., Testoni, N., Pierini, V., Ciolli, S., Sambani, C., Locasciulli, A., Di Bona, E., Lafage-Pochitaloff, M., Martelli, M. F., Marynen, P., and Mecucci, C.

Subjects
*MYELODYSPLASTIC syndromes, *BONE marrow diseases, *MYELOID leukemia, *REARRANGEMENTS (Chemistry), *CHEMICAL reactions, *FLUORESCENCE in situ hybridization
Abstract

Fluorescence in situ hybridization and comparative genomic hybridization characterized 6p rearrangements in eight primary and in 10 secondary myeloid disorders (including one patient with Fanconi anemia) and found different molecular lesions in each group. In primary disorders, 6p abnormalities, isolated in six patients, were highly heterogeneous with different breakpoints along the 6p arm. Reciprocal translocations were found in seven. In the 10 patients with secondary acute myeloid leukemia/myelodysplastic syndrome (AML/MDS), the short arm of chromosome 6 was involved in unbalanced translocations in 7. The other three patients showed full or partial trisomy of the 6p arm, that is, i(6)(p10) (one patient) and dup(6)(p) (two patients). In 5/7 patients with unbalanced translocations, DNA sequences were overrepresented at band 6p21 as either cryptic duplications (three patients) or cryptic low-copy gains (two patients). In the eight patients with cytogenetic or cryptic 6p gains, we identified a common overrepresented region extending for 5–6 megabases from the TNF gene to the ETV-7 gene. 6p abnormalities were isolated karyotype changes in four patients. Consequently, in secondary AML/MDS, we hypothesize that 6p gains are major pathogenetic events arising from acquired and/or congenital genomic instability.Leukemia (2006) 20, 958–964. doi:10.1038/sj.leu.2404208; published online 13 April 2006 [ABSTRACT FROM AUTHOR]

Published
2006
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316. Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-azacytidine.

Author

Voso, M T, Fabiani, E, Piciocchi, A, Matteucci, C, Brandimarte, L, Finelli, C, Pogliani, E, Angelucci, E, Fioritoni, G, Musto, P, Greco, M, Criscuolo, M, Fianchi, L, Vignetti, M, Santini, V, Hohaus, S, Mecucci, C, and Leone, G

Subjects
*LETTERS to the editor, *METHYLATION, *AZACITIDINE, *THERAPEUTIC use of antimetabolites, *THERAPEUTIC use of antineoplastic agents, *PROTEINS, *MYELODYSPLASTIC syndromes, *SURVIVAL, *RESEARCH, *GENETIC mutation, *RESEARCH methodology, *PROGNOSIS, *RETROSPECTIVE studies, *MEDICAL cooperation, *EVALUATION research, *DNA methylation, *COMPARATIVE studies, *DNA-binding proteins
Abstract

A letter to the editor is presented which discusses the prognostic role of TET2 mutations BCL2L10 methylation profiling on patients with high risk of myelodysplastic syndrome with 5-azacytidine.

Published
2011
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317. The activation of human endogenous retrovirus K (HERV-K) is implicated in melanoma cell malignant transformation

Author

Serafino, A., Balestrieri, E., Pierimarchi, P., Matteucci, C., Moroni, G., Oricchio, E., Rasi, G., Mastino, A., Spadafora, C., Garaci, E., and Vallebona, P. Sinibaldi

Subjects
*MELANOMA, *RETROVIRUS genetics, *CANCER cells, *CELL transformation, *RNA, *GENE expression, *GENETICS
Abstract

Abstract: Melanoma development is a multi-step process arising from a series of genetic and epigenetic events. Although the sequential stages involved in progression from melanocytes to malignant melanoma are clearly defined, our current understanding of the mechanisms leading to melanoma onset is still incomplete. Growing evidence show that the activation of endogenous retroviral sequences might be involved in transformation of melanocytes as well as in the increased ability of melanoma cells to escape immune surveillance. Here we show that human melanoma cells in vitro undergo a transition from adherent to a more malignant, non-adherent phenotype when exposed to stress conditions. Melanoma-derived non-adherent cells are characterized by an increased proliferative potential and a decreased expression of both HLA class I molecules and Melan-A/MART-1 antigen, similarly to highly malignant cells. These phenotypic and functional modifications are accompanied by the activation of human endogenous retrovirus K expression (HERV-K) and massive production of viral-like particles. Down-regulation of HERV-K expression by RNA interference prevents the transition from the adherent to the non-adherent growth phenotype in low serum. These results implicate HERV-K in at least some critical steps of melanoma progression. [Copyright &y& Elsevier]

Published
2009
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318. Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA).

Author

Luchetti, M.M., Piccinini, G., Mantovani, A., Peri, G., Matteucci, C., Pomponio, G., Fratini, M., Frayicelli, P., Sambo, P., Di Loreto, C., Doni, A., Introna, M., and Gabrielli, A.

Subjects
*GENES, *RHEUMATOID arthritis, *RNA, *CYTOKINES, *OSTEOARTHRITIS, *PATIENTS
Abstract

Investigates the inducible and constitutive expression of pentraxin PTX3 gene on patients with rheumatoid arthritis (RA). Analysis on synovial cell cultures; Isolation and extraction of ribonucleic acid; Cytokine modulation of PTX3 gene expression in RA and osteoarthritis.

Published
2000
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319. A multi-analytical approach for the characterisation of 20th century paintings

Author

Salvatore Andrea Apicella, Flavia Fiorillo, Chiara Matteucci, Mariangela Vandini, Martina Cataldo, Fiorillo F., Matteucci C., Cataldo M., Apicella S.A., and Vandini M.

Subjects
Fluid Flow and Transfer Processes, Scientific technique, Painting, Information retrieval, Computer science, Specific time, General Physics and Astronomy, Painting, 20th century, materials characterisation, EDXRF, SEM-EDS, micro-FTIR, micro-Raman, 20th-century art
Abstract

A basic rule of thumb in art identification is the employment of scientific techniques as they provide pivotal information on the complex structure of paintings. This research will show how two selected case studies (Mon Amour, attributed to Picasso and Bathing Women, attributed to Munch) allowed to test a methodological approach aimed at the characterisation of a wide variety of materials commonly used in 20th century art. The combined set of analyses consisted of preliminary non-invasive imaging techniques and portable X-ray fluorescence spectroscopy (EDXRF); the second stage of the protocol was the characterisation of the selected samples cross-section by means of Scanning Electron Microscopy (SEM-EDS), Fourier Transform Infrared (FTIR) and Raman microscopy. The material characterisation has allowed to date the two paintings within the lifetime of the supposed artists, due to the presence of synthetic organic compounds as PR3 and PG7. In order to confirm or refuse a compatibility with an artist, the data obtained were correlated with those reported in the literature; but the lack of published data did not allow to compare and evaluate the two specific time spans for authentication purpose. Thus, the following study will propose a best practice for the characterisation of 20th century pigments, discusses challenges in the authentication field and underlines the importance of the sharing of results even for paintings of dubious attribution.

Published
2019

321. Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study

Author

Carlotta Matteucci, Letizia Zannoni, Roberto Paradisi, Renato Seracchioli, Chiara Facchini, Giulia Ferrini, and Paradisi R, Ferrini G, Matteucci C, Facchini C, Zannoni L, Seracchioli R

Subjects
Adult, medicine.medical_specialty, Hyperhomocysteinemia, Factor ii prothrombin, Endometriosis, Pilot Projects, Thrombophilic disorders, lcsh:Gynecology and obstetrics, 03 medical and health sciences, 0302 clinical medicine, Healthy control, medicine, Genetic predisposition, Factor V Leiden, Humans, Mass Screening, Thrombophilia, In patient, Genetic Predisposition to Disease, Endometriosi, lcsh:RG1-991, Retrospective Studies, Gynecology, 030219 obstetrics & reproductive medicine, Obstetrics, business.industry, 030503 health policy & services, Obstetrics and Gynecology, Factor V, Retrospective cohort study, medicine.disease, Case-Control Studies, Female, Factor II prothrombin, 0305 other medical science, business
Abstract

OBJECTIVE: At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis. MATERIALS AND METHODS: We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis. RESULTS: A significant reduced prevalence (p < 0.05) of factor V Leiden mutation in endometriosis patients was found, whereas no significant differences (p = NS) for factor II and hyperhomocysteinemia were observed. CONCLUSION: Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis.

Published
2017

322. Imitatori e interpreti: la parabola dell’eclettismo fenicio

Author

FARISELLI, A. C., GARZIA G., MATTEUCCI C., VANDINI M., and FARISELLI, A.C.

Subjects
IMITAZIONI, COPIE, FALSO, SINCRETISMO CULTURALE, FENICI, CARTAGINESI, ARTIGIANATO
Abstract

Il contributo affronta il complesso tema dell'eclettismo dell'artigianato fenicio partendo dal tentativo di individuare cosa possa essere considerato falso, cosa imitazione e cosa frutto di sincretismo e ispirazione fra le produzioni tipiche di questa civiltà. Nel contesto della cultura materiale fenicia e punica il problema è assai difficoltoso da dirimere, essendo la civiltà fenicia naturalmente permeabile a vari influssi e suggestioni a causa dei molteplici rapporti commerciali intrattenuti dai marinai fenici e cartaginesi con altre genti del Mediterraneo orientale e centro-occidentale sin dalle radici della storia siro-palestinese.

Published
2018

323. Prognostic Impact of Diabetes and Prediabetes on Survival Outcomes in Patients With Chronic Heart Failure: A Post-Hoc Analysis of the GISSI-HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca-Heart Failure) Trial

Author

Marco Dauriz, Giovanni Targher, Pier Luigi Temporelli, Donata Lucci, Lucio Gonzini, Gian Luigi Nicolosi, Roberto Marchioli, Gianni Tognoni, Roberto Latini, Franco Cosmi, Luigi Tavazzi, Aldo Pietro Maggioni, Simona Barlera, Maria Grazia Franzosi, Aldo P. Maggioni, Maurizio Porcu, Salim Yusuf, Fulvio Camerini, Jay N. Cohn, Adriano Decarli, Bertram Pitt, Peter Sleight, Philip A. Poole‐Wilson, Enrico Geraci, Marino Scherillo, Gianna Fabbri, Barbara Bartolomei, Daniele Bertoli, Franco Cobelli, Claudio Fresco, Antonietta Ledda, Giacomo Levantesi, Cristina Opasich, Franco Rusconi, Gianfranco Sinagra, Fabio Turazza, Alberto Volpi, Martina Ceseri, Gianluca Alongi, Antonio Atzori, Filippo Bambi, Desiree Bastarolo, Francesca Bianchini, Iacopo Cangioli, Vittoriana Canu, Concetta Caporusso, Gabriele Cenni, Laura Cintelli, Michele Cocchio, Alessia Confente, Eva Fenicia, Giorgio Friso, Marco Gianfriddo, Gianluca Grilli, Beatrice Lazzaro, Giuseppe Lonardo, Alessia Luise, Rachele Nota, Mariaelena Orlando, Rosaria Petrolo, Chiara Pierattini, Valeria Pierota, Alessandro Provenzani, Velia Quartuccio, Anna Ragno, Chiara Serio, Alvise Spolaor, Arianna Tafi, Elisa Tellaroli, Stefano Ghio, Elisa Ghizzardi, Serge Masson, Lella Crociati, Maria Teresa La Rovere, Ugo Corrà, Andrea Finzi, Marco Gorini, Valentina Milani, Giampietro Orsini, Elisa Bianchini, Silvia Cabiddu, Ilaria Cangioli, Laura Cipressa, Maria Lucia Cipressa, Giuseppina Di Bitetto, Barbara Ferri, Luisa Galbiati, Andrea Lorimer, Carla Pera, Paola Priami, Antonella Vasamì, T. Moccetti, M.G. Rossi, E. Pasotti, F. Vaghi, P. Roncarolo, M.T. Zunino, F. Matta, E. Actis Perinetto, F. Gaita, G. Azzaro, M. Zanetta, A.M. Paino, U. Parravicini, D. Vegis, R. Conte, P. Ferraro, A. De Bernardi, S. Morelloni, M. Fagnani, P. Greco Lucchina, L. Montagna, E. Bellone, D. Sappè, F. Ferraro, M. Delucchi, S.G. Reynaud, M. Dore, A. La Brocca, N. Massobrio, L. Bo, R. Trinchero, M. Imazio, G. Brocchi, A. Nejrotti, L. Rissone, S. Gabasio, C. Zocchi, S. Randazzo, A. Crenna, P. Giannuzzi, E. Bonanomi, A. Mezzani, M. De Marchi, G. Begliuomini, C.A. Gianonatti, A. Gavazzi, A. Grosu, L. Dei Cas, S. Nodari, P. Garyfallidis, A. Bertoletti, C. Bonifazi, S. Arisi, F. Mascaro, M. Fraccarollo, S. Dell'Orto, M. Sfolcini, F. Bortolini, D. Raccagni, A. Turelli, M. Santarone, E. Miglierina, L. Sormani, R. Jemoli, F. Tettamanti, S. Pirelli, C. Bianchi, S. Verde, M. Mariani, V. Ziacchi, A. Ferrazza, A. Russo, M. Bortolotti, G.F. Pasini, A. Volpi, K.N. Jones, D. Cuzzucrea, G. Gullace, C. Carbone, A. Granata, S. De Servi, G. Del Rosso, C. Inserra, E. Renaldini, C. Zappa, M. Moretti, R. Zanini, M. Ferrari, E. Moroni, A. Cei, C. Lissi, E. Dovico, C. Fiorentini, P. Palermo, B. Brusoni, M. Negrini, J. Heyman, G.B. Danzi, A. Finzi, M. Frigerio, F. Turazza, L. Beretta, A. Sachero, F. Casazza, L. Squadroni, F. Lombardi, L. Marano, A. Margonato, G. Fragasso, O.C. Febo, E. Aiolfi, F. Olmetti, A. Grieco, V. Antonazzo, G. Specchia, A. Mortara, F. Robustelli, M.G. Songini, C. Schweiger, A. Frisinghelli, M. Palvarini, C. Campana, L. Scelsi, N. Ajmone Marsan, F. Cobelli, A. Gualco, C. Opasich, S. De Feo, R. Mazzucco, M.A. Iannone, T. Diaco, D. Zaniboni, G. Milanesi, D. Nassiacos, S. Meloni, P. Giani, T. Nicoli, C. Malinverni, A. Gusmini, L. Pozzoni, G. Bisiani, P. Margaroli, A. Schizzarotto, A. Daverio, G. Occhi, N. Partesana, P. Bandini, M.G. Rosella, S. Giustiniani, G. Cucchi, R. Pedretti, R. Raimondo, R. Vaninetti, A. Fedele, I. Ghezzi, E. Rezzonico, J.A. Salerno Uriarte, F. Morandi, F. Salvucci, C. Valenti, G. Graziano, M. Romanò, C. Cimminiello, I. Mangone, M. Lombardo, P. Quorso, G. Marinoni, M. Breghi, M. Erckert, A. Dienstl, G. Mirante Marini, C. Stefenelli, G. Cioffi, E. Buczkowska, A. Bonanome, F. Bazzanini, L. Parissenti, C. Serafini, G. Catania, L. Tarantini, G. Rigatelli, S. Boni, A. Pasini, E. Masini, A.A. Zampiero, M. Zanchetta, L. Franceschetto, P. Delise, C. Marcon, A. Sacchetta, L. Borgese, L. Artusi, P. Casolino, F. Corbara, A. Banzato, M. Barbiero, M.P. Aldegheri, R. Bazzucco, G. Crivellenti, A. Raviele, C. Zanella, P. Pascotto, P. Sarto, S. Milan, E. Barbieri, P. Girardi, W. Dalla Villa, J. Dalle Mule, M.L. Di Sipio, R. Cazzin, D. Milan, P. Zonzin, M. Carraro, R. Rossi, E. Carbonieri, I. Rossi, P. Stritoni, P. Meneghetti, G. Risica, P.L. Tenderini, C. Vassanelli, L. Zanolla, G. Perini, G. Brighetti, R. Chiozza, G. Giuliano, R. Gortan, R. Cesanelli, G.L. Nicolosi, R. Piazza, L. Mos, O. Vriz, D. Pavan, G. Pascottini, E. Alberti, M. Werren, L. Solinas, G. Sinagra, F. Longaro, P. Fioretti, M.C. Albanese, D. Miani, R. Gianrossi, A. Pende, P. Rubartelli, O. Magaia, S. Domenicucci, D. Caruso, A.S. Faraguti, L. Magliani, F. Miccoli, G. Guglielmino, D. Bertoli, A. Cantarelli, S. Orlandi, A. Vallebona, A. Pozzati, G. Brega, L.G. Pancaldi, R. Vandelli, S. Urbinati, M.G. Poci, M. Zoli, G.M. Costa, U. Guiducci, G. Zobbi, F. Tartagni, A. Tisselli, A. Gentili, P. Pieri, E. Cagnetta, S. Bendinelli, A. Barbieri, R. Conti, R. Ferrari, F. Merlini, A. Fucili, P. Moruzzi, E. Buia, M. Galvani, D. Ferrini, G. Baggioni, P. Yiannacopulu, G. Canè, A. Bonfiglioli, R. Zandomeneghi, L. Brugioni, A. Giannini, R. Di Ruvo, M. Giuliani, L. Rusconi, P. Del Corso, G. Piovaccari, F. Bologna, P. Venturi, F. Melandri, E. Bagni, L. Bolognese, R. Perticucci, A. Zuppiroli, M. Nannini, N. Consoli, P. Petrone, C. Pipitò, L. Colombi, D. Bernardi, P.R. Mariani, R. Testa, F. Mazzinghi, F. Cosmi, D. Cosmi, A. Zipoli, A. Cecchi, G. Castelli, M. Ciaccheri, F. Mori, F. Pieri, P. Valoti, D. Chiarantini, G.M. Santoro, C. Minneci, F. Marchi, M. Milli, G. Zambaldi, A.A. Brandinelli Geri, M. Cipriani, M. Alessandri, S. Severi, S. Stefanelli, A. Comella, R. Poddighe, A. Digiorgio, M. Carluccio, S. Berti, A. Rizza, V. Bonatti, V. Molendi, A. Brancato, N. D'Aprile, G. Giappichini, S. Del Vecchio, G. Mantini, F. De Tommasi, G. Meucci, M. Cordoni, S. Bechi, L. Barsotti, P. Baldini, M. Romei, G. Scopelliti, G. Lauri, F. Pestelli, F. Furiozzi, M. Cocchieri, D. Severini, F. Patriarchi, P. Chiocchi, M. Buccolieri, S. Martinelli, A. Wee, F. Angelici, M. Bernardinangeli, G. Proietti, B. Biscottini, R. Panciarola, L. Marinacci, G.P. Perna, D. Gabrielli, A. Moraca, L. Moretti, L. Partemi, G. Gregori, R. Amici, G. Patteri, P. Capone, E. Savini, G.L. Morgagni, L. Paccaloni, F. Pezzuoli, S. Carincola, S. Papi, S. De Crescentini, P. Gerardi, P. Midi, E. Gallenzi, G. Pajes, C. Mancone, V. Di Spirito, M. Di Gennaro, S. Calcagno, S. Toscano, S. Antonicoli, F. Carta, G. Giorgi, F. Comito, E. Daniele, O. Ciarla, P.G. Gelfo, A. Acquaviva, D. Testa, G. Testa, F.A. Pagliaro, F. Russo, F. Vetta, I. Marchese, G. Di Sciascio, A. D'Ambrosio, F. Leggio, D. Del Sindaco, A. Lacchè, A. Avallone, M.P. Risa, P. Azzolini, E. Baldo, E. Giovannini, G. Pulignano, C. Tondo, E. Picchio, E. ani, P. Tanzi, F. Pozzar, F. Farnetti, M. Azzarito, M. Santini, A. Varveri, G. Ferraiuolo, C. Valtorta, A. Gaspardone, G. Barbato, V. Ceci, N. Aspromonte, F. Bellocci, C. Colizzi, F. Fedele, F.I. Perez, A. Galati, A. Rossetti, A. Mainella, D. etta, C. Matteucci, G. Busi, A. De Angelis, G. Farina, A. Granatelli, F. Leone, F. Frasca, R. Di Giovambattista, G. Castellani, G. Massaro, G. Mastrogiuseppe, A. Vacri, F. De Sanctis, M. Cioli, S. Di Luzio, C. Napoletano, L.L. Piccioni, G. De Simone, A. Ottaviano, V. Mazza, C. Spedaliere, D. Staniscia, E. Calgione, G. De Marco, T. Chiacchio, T. Di Napoli, S. Romanzi, G. Salvatore, P. Golino, A. Palermo, F. Mascia, A. Vetrano, A. Vinciguerra, L. Caliendo, R. Longobardi, G. De Caro, R. Di Nola, F. Piemonte, D. Prinzi, P. De Rosa, V. De Rosa, F. Riello, V. Capuano, G. Vecchio, M. Landi, S. Amato, M. Garofalo, M. D'Avino, P. Sensale, O. Maiolica, R. Santoro, P. Caso, D. Miceli, N. Maurea, U. Bianchi, C. Crispo, M. Chiariello, P. Perrone Filardi, L. Russo, N. Capuano, G. Ungaro, G. Vergara, F. Scafuro, G. D'Angelo, C. Campaniello, P. Bottiglieri, A. Volpe, R. Battista, L. De Risi, G. Cardillo, G. Sibilio, A.P. Marino, F. Silvestri, P. Predotti, A. Iervoglini, C. De Matteis, P. Sarnicola, M.M. Matarazzo, S. Baldi, V. Iuliano, C. Astarita, P. Cuccaro, A. Liguori, G. Liguori, G. Gregorio, L. Petraglia, G. Antonelli, G. Amodio, I. De Luca, D. Traversa, G. Franchini, M.L. Lenti, D. Cavallari, C. D'Agostino, G. Scalera, C.M. Altamura, M. Russo, A.R. Mascolo, G. Pettinati, S.A. Ciricugno, D. Scrutinio, A. Passantino, D. Mastrangelo, A. Di Masi, R. De Carne, M. Cannone, F. Dibiase, M. Pensato, F. Loliva, F. Trapani, I. Panettieri, L. Leone, M. Di Biase, M. Carrone, V. Gallone, F. Cocco, M. Costantini, C. Tritto, F. Cavalieri, L. Stella, F. Magliari, M. Callerame, A. De Giorgi, L. Pellegrino, M. Correra, V. Portulano, G.L. Nisi, G. Grassi, E. Cristallo, D. De Laura, C. Salerno, R. Fanelli, M. Villella, S. Pede, A. Renna, E. De Lorenzi, L. Urso, V. Lenti, A. Peluso, N. Baldi, G. Polimeni, P. Palma, R. Lauletta, E. Tagliamonte, T. Cirillo, B. Silvestri, G. Centonze, B. D'Alessandro, L. Truncellito, D. Mecca, M.A. Petruzzi, R.O.M. Coviello, A. Lopizzo, M. telli, S. Barbuzzi, S. Gubelli, G. Germinario, N. Cosentino, A. Mingrone, R. Vico, G. Borrello, M.L. Mazza, R. Cimino, D. Galasso, F. Cassadonte, U. Talarico, F. Perticone, S. Cassano, F. Catapano, S. Calemme, E. Feraco, C. Cloro, G. Misuraca, R. Caporale, L. Vigna, V. Spagnuolo, F. De Rosa, G. Spadafora, G. Zampaglione, R. Russo, F.A. Schipani, A.F. Ferragina, D. Stranieri, G. Musca, C. Carpino, P. Bencardino, F. Raimondo, D. Musacchio, G. Pulitanò, A. Ruggeri, A. Provenzano, S. Salituri, M. Musolino, S. Calandruccio, A. Marrari, E. Tripodi, R. Scali, L. Anastasio, A. Arone, P. Aragona, L. Donnangelo, M.G.A. Comito, F. Bilotta, I. Vaccaro, R. Rametta, V. Ventura, A. Bonvegna, A. Alì, C. Cinnirella, M. Raineri, F. Pompeo, N. Cascio Ingurgio, V. Carini, R. Coco, G. Giunta, G. Leonardi, V. Randazzo, V. Di Blasi, C. Tamburino, G. Russo, S. Mangiameli, R. Cardillo, D. Castelli, V. Inserra, A. Arena, M.M. Gulizia, S. Raciti, G. Rapisarda, R. Romano, P. Prestifilippo, G.B. Braschi, G. Ledda, R. Terrazzino, M. De Caro, G. Scilabra, B. agnino, R. Grassi, G. Di Tano, G.F. Scimone, L. Vasquez, C. Coppolino, A. Casale, M. Castelli, G. D'Urso, E. D'Antonio, L. Lo Presti, E. Badalamenti, P. Conti, N. Sanfilippo, V. Cirrincione, M.T. Cinà, G. Cusimano, A. Taormina, P. Giuliano, A. Bajardi, V. Mandalà, A. Canonico, G. Geraci, F.P. Sabella, F. Enia, A.M. Floresta, I. Lo Cascio, D. Gumina, A. Cavallaro, G. Piccione, R. Ferrante, M. Blandino, M.S. Iudicello, E. Mossuti, G. Romano, L. Lombardo, P. Monastra, D. Di Vincenzo, M. Porcu, P. Orrù, F. Muscas, G. Giardina, M. Corda, G. Locci, A. Podda, M. Ledda, P. Siddi, C. Lai, G. Pili, G. Mercuro, G. Mureddu, A. Ganau, G. Meloni, G. Poddighe, G. Sanna, Dauriz, Marco, Targher, Giovanni, Temporelli, Pier Luigi, Lucci, Donata, Gonzini, Lucio, Nicolosi, Gian Luigi, Marchioli, Roberto, Tognoni, Gianni, Latini, Roberto, Cosmi, Franco, Tavazzi, Luigi, Maggioni, Aldo Pietro, on behalf of the GISSI-HF, Investigator, Margonato, Alberto, Moccetti, T., Rossi, M. G., Pasotti, E., Vaghi, F., Roncarolo, P., Zunino, M. T., Matta, F., Actis Perinetto, E., Gaita, F., Azzaro, G., Zanetta, M., Paino, A. M., Parravicini, U., Vegis, D., Conte, R., Ferraro, P., De Bernardi, A., Morelloni, S., Fagnani, M., Greco Lucchina, P., Montagna, L., Bellone, E., Sappè, D., Ferraro, F., Delucchi, M., Reynaud, S. G., Dore, M., La Brocca, A., Massobrio, N., Bo, L., Trinchero, R., Imazio, M., Brocchi, G., Nejrotti, A., Rissone, L., Gabasio, S., Zocchi, C., Randazzo, S., Crenna, A., Giannuzzi, P., Bonanomi, E., Mezzani, A., De Marchi, M., Begliuomini, G., Gianonatti, C. A., Gavazzi, A., Grosu, A., Dei Cas, L., Nodari, S., Garyfallidis, P., Bertoletti, A., Bonifazi, C., Arisi, S., Mascaro, F., Fraccarollo, M., Dell'Orto, S., Sfolcini, M., Bortolini, F., Raccagni, D., Turelli, A., Santarone, M., Miglierina, E., Sormani, L., Jemoli, R., Tettamanti, F., Pirelli, S., Bianchi, C., Verde, S., Mariani, M., Ziacchi, V., Ferrazza, A., Russo, A., Bortolotti, M., Pasini, G. F., Volpi, A., Jones, K. N., Cuzzucrea, D., Gullace, G., Carbone, C., Granata, A., De Servi, S., Del Rosso, G., Inserra, C., Renaldini, E., Zappa, C., Moretti, M., Zanini, R., Ferrari, M., Moroni, E., Cei, A., Lissi, C., Dovico, E., Fiorentini, C., Palermo, P., Brusoni, B., Negrini, M., Heyman, J., Danzi, G. B., Finzi, A., Frigerio, M., Turazza, F., Beretta, L., Sachero, A., Casazza, F., Squadroni, L., Lombardi, F., Marano, L., Margonato, A., Fragasso, G., Febo, O. C., Aiolfi, E., Olmetti, F., Grieco, A., Antonazzo, V., Specchia, G., Mortara, A., Robustelli, F., Songini, M. G., Schweiger, C., Frisinghelli, A., Palvarini, M., Campana, C., Scelsi, L., Ajmone Marsan, N., Cobelli, F., Gualco, A., Opasich, C., De Feo, S., Mazzucco, R., Iannone, M. A., Diaco, T., Zaniboni, D., Milanesi, G., Nassiacos, D., Meloni, S., Giani, P., Nicoli, T., Malinverni, C., Gusmini, A., Pozzoni, L., Bisiani, G., Margaroli, P., Schizzarotto, A., Daverio, A., Occhi, G., Partesana, N., Bandini, P., Rosella, M. G., Giustiniani, S., Cucchi, G., Pedretti, R., Raimondo, R., Vaninetti, R., Fedele, A., Ghezzi, I., Rezzonico, E., Salerno Uriarte, J. A., Morandi, F., Salvucci, F., Valenti, C., Graziano, G., Romanò, M., Cimminiello, C., Mangone, I., Lombardo, M., Quorso, P., Marinoni, G., Breghi, M., Erckert, M., Dienstl, A., Mirante Marini, G., Stefenelli, C., Cioffi, G., Buczkowska, E., Bonanome, A., Bazzanini, F., Parissenti, L., Serafini, C., Catania, G., Tarantini, L., Rigatelli, G., Boni, S., Pasini, A., Masini, E., Zampiero, A. A., Zanchetta, M., Franceschetto, L., Delise, P., Marcon, C., Sacchetta, A., Borgese, L., Artusi, L., Casolino, P., Corbara, F., Banzato, A., Barbiero, M., Aldegheri, M. P., Bazzucco, R., Crivellenti, G., Raviele, A., Zanella, C., Pascotto, P., Sarto, P., Milan, S., Barbieri, E., Girardi, P., Dalla Villa, W., Dalle Mule, J., Di Sipio, M. L., Cazzin, R., Milan, D., Zonzin, P., Carraro, M., Rossi, R., Carbonieri, E., Rossi, I., Stritoni, P., Meneghetti, P., Risica, G., Tenderini, P. L., Vassanelli, C., Zanolla, L., Perini, G., Brighetti, G., Chiozza, R., Giuliano, G., Baldin, M. G., Gortan, R., Cesanelli, R., Nicolosi, G. L., Piazza, R., Mos, L., Vriz, O., Pavan, D., Pascottini, G., Alberti, E., Werren, M., Solinas, L., Sinagra, G., Longaro, F., Fioretti, P., Albanese, M. C., Miani, D., Gianrossi, R., Pende, A., Rubartelli, P., Magaia, O., Domenicucci, S., Caruso, D., Faraguti, A. S., Magliani, L., Miccoli, F., Guglielmino, G., Bertoli, D., Cantarelli, A., Orlandi, S., Vallebona, A., Pozzati, A., Brega, G., Pancaldi, L. G., Vandelli, R., Urbinati, S., Poci, M. G., Zoli, M., Costa, G. M., Guiducci, U., Zobbi, G., Tartagni, F., Tisselli, A., Gentili, A., Pieri, P., Cagnetta, E., Bendinelli, S., Barbieri, A., Conti, R., Ferrari, R., Merlini, F., Fucili, A., Moruzzi, P., Buia, E., Galvani, M., Ferrini, D., Baggioni, G., Yiannacopulu, P., Canè, G., Bonfiglioli, A., Zandomeneghi, R., Brugioni, L., Giannini, A., Di Ruvo, R., Giuliani, M., Rusconi, L., Del Corso, P., Piovaccari, G., Bologna, F., Venturi, P., Melandri, F., Bagni, E., Bolognese, L., Perticucci, R., Zuppiroli, A., Nannini, M., Consoli, N., Petrone, P., Pipitò, C., Colombi, L., Bernardi, D., Mariani, P. R., Testa, R., Mazzinghi, F., Cosmi, F., Cosmi, D., Zipoli, A., Cecchi, A., Castelli, G., Ciaccheri, M., Mori, F., Pieri, F., Valoti, P., Chiarantini, D., Santoro, G. M., Minneci, C., Marchi, F., Milli, M., Zambaldi, G., Brandinelli Geri, A. A., Cipriani, M., Alessandri, M., Severi, S., Stefanelli, S., Comella, A., Poddighe, R., Digiorgio, A., Carluccio, M., Berti, S., Rizza, A., Bonatti, V., Molendi, V., Brancato, A., D'Aprile, N., Giappichini, G., Del Vecchio, S., Mantini, G., De Tommasi, F., Meucci, G., Cordoni, M., Bechi, S., Barsotti, L., Baldini, P., Romei, M., Scopelliti, G., Lauri, G., Pestelli, F., Furiozzi, F., Cocchieri, M., Severini, D., Patriarchi, F., Chiocchi, P., Buccolieri, M., Martinelli, S., Wee, A., Angelici, F., Bernardinangeli, M., Proietti, G., Biscottini, B., Panciarola, R., Marinacci, L., Perna, G. P., Gabrielli, D., Moraca, A., Moretti, L., Partemi, L., Gregori, G., Amici, R., Patteri, G., Capone, P., Savini, E., Morgagni, G. L., Paccaloni, L., Pezzuoli, F., Carincola, S., Papi, S., De Crescentini, S., Gerardi, P., Midi, P., Gallenzi, E., Pajes, G., Mancone, C., Di Spirito, V., Di Gennaro, M., Calcagno, S., Toscano, S., Antonicoli, S., Carta, F., Giorgi, G., Comito, F., Daniele, E., Ciarla, O., Gelfo, P. G., Acquaviva, A., Testa, D., Testa, G., Pagliaro, F. A., Russo, F., Vetta, F., Marchese, I., Di Sciascio, G., D'Ambrosio, A., Leggio, F., Del Sindaco, D., Lacchè, A., Avallone, A., Risa, M. P., Azzolini, P., Baldo, E., Giovannini, E., Pulignano, G., Tondo, C., Picchio, E., Biffani, E., Tanzi, P., Pozzar, F., Farnetti, F., Azzarito, M., Santini, M., Varveri, A., Ferraiuolo, G., Valtorta, C., Gaspardone, A., Barbato, G., Ceci, V., Aspromonte, N., Bellocci, F., Colizzi, C., Fedele, F., Perez, F. I., Galati, A., Rossetti, A., Mainella, A., Ciuffetta, D., Matteucci, C., Busi, G., De Angelis, A., Farina, G., Granatelli, A., Leone, F., Frasca, F., Di Giovambattista, R., Castellani, G., Massaro, G., Mastrogiuseppe, G., Vacri, A., De Sanctis, F., Cioli, M., Di Luzio, S., Napoletano, C., Piccioni, L. L., De Simone, G., Ottaviano, A., Mazza, V., Spedaliere, C., Staniscia, D., Calgione, E., De Marco, G., Chiacchio, T., Di Napoli, T., Romanzi, S., Salvatore, G., Golino, P., Palermo, A., Mascia, F., Vetrano, A., Vinciguerra, A., Caliendo, L., Longobardi, R., De Caro, G., Di Nola, R., Piemonte, F., Prinzi, D., De Rosa, P., De Rosa, V., Riello, F., Capuano, V., Vecchio, G., Landi, M., Amato, S., Garofalo, M., D'Avino, M., Sensale, P., Maiolica, O., Santoro, R., Caso, P., Miceli, D., Maurea, N., Bianchi, U., Crispo, C., Chiariello, M., Perrone Filardi, P., Russo, L., Capuano, N., Ungaro, G., Vergara, G., Scafuro, F., D'Angelo, G., Campaniello, C., Bottiglieri, P., Volpe, A., Battista, R., De Risi, L., Cardillo, G., Sibilio, G., Marino, A. P., Silvestri, F., Predotti, P., Iervoglini, A., De Matteis, C., Sarnicola, P., Matarazzo, M. M., Baldi, S., Iuliano, V., Astarita, C., Cuccaro, P., Liguori, A., Liguori, G., Gregorio, G., Petraglia, L., Antonelli, G., Amodio, G., De Luca, I., Traversa, D., Franchini, G., Lenti, M. L., Cavallari, D., D'Agostino, C., Scalera, G., Altamura, C. M., Russo, M., Mascolo, A. R., Pettinati, G., Ciricugno, S. A., Scrutinio, D., Passantino, A., Mastrangelo, D., Di Masi, A., De Carne, R., Cannone, M., Dibiase, F., Pensato, M., Loliva, F., Trapani, F., Panettieri, I., Leone, L., Di Biase, M., Carrone, M., Gallone, V., Cocco, F., Costantini, M., Tritto, C., Cavalieri, F., Stella, L., Magliari, F., Callerame, M., De Giorgi, A., Pellegrino, L., Correra, M., Portulano, V., Nisi, G. L., Grassi, G., Cristallo, E., De Laura, D., Salerno, C., Fanelli, R., Villella, M., Pede, S., Renna, A., De Lorenzi, E., Urso, L., Lenti, V., Peluso, A., Baldi, N., Polimeni, G., Palma, P., Lauletta, R., Tagliamonte, E., Cirillo, T., Silvestri, B., Centonze, G., D'Alessandro, B., Truncellito, L., Mecca, D., Petruzzi, M. A., Coviello, R. O. M., Lopizzo, A., Chiaffitelli, M., Barbuzzi, S., Gubelli, S., Germinario, G., Cosentino, N., Mingrone, A., Vico, R., Borrello, G., Mazza, M. L., Cimino, R., Galasso, D., Cassadonte, F., Talarico, U., Perticone, F., Cassano, S., Catapano, F., Calemme, S., Feraco, E., Cloro, C., Misuraca, G., Caporale, R., Vigna, L., Spagnuolo, V., De Rosa, F., Spadafora, G., Zampaglione, G., Russo, R., Schipani, F. A., Ferragina, A. F., Stranieri, D., Musca, G., Carpino, C., Bencardino, P., Raimondo, F., Musacchio, D., Pulitanò, G., Ruggeri, A., Provenzano, A., Salituri, S., Musolino, M., Calandruccio, S., Marrari, A., Tripodi, E., Scali, R., Anastasio, L., Arone, A., Aragona, P., Donnangelo, L., Comito, M. G. A., Bilotta, F., Vaccaro, I., Rametta, R., Ventura, V., Bonvegna, A., Alì, A., Cinnirella, C., Raineri, M., Pompeo, F., Cascio Ingurgio, N., Carini, V., Coco, R., Giunta, G., Leonardi, G., Randazzo, V., Di Blasi, V., Tamburino, C., Russo, G., Mangiameli, S., Cardillo, R., Castelli, D., Inserra, V., Arena, A., Gulizia, M. M., Raciti, S., Rapisarda, G., Romano, R., Prestifilippo, P., Braschi, G. B., Ledda, G., Terrazzino, R., De Caro, M., Scilabra, G., Graffagnino, B., Grassi, R., Di Tano, G., Scimone, G. F., Vasquez, L., Coppolino, C., Casale, A., Castelli, M., D'Urso, G., D'Antonio, E., Lo Presti, L., Badalamenti, E., Conti, P., Sanfilippo, N., Cirrincione, V., Cinà, M. T., Cusimano, G., Taormina, A., Giuliano, P., Bajardi, A., Mandalà, V., Canonico, A., Geraci, G., Sabella, F. P., Enia, F., Floresta, A. M., Lo Cascio, I., Gumina, D., Cavallaro, A., Piccione, G., Ferrante, R., Blandino, M., Iudicello, M. S., Mossuti, E., Romano, G., Lombardo, L., Monastra, P., Di Vincenzo, D., Porcu, M., Orrù, P., Muscas, F., Giardina, G., Corda, M., Locci, G., Podda, A., Ledda, M., Siddi, P., Lai, C., Pili, G., Mercuro, G., Mureddu, G., Ganau, A., Meloni, G., Poddighe, G., Sanna, G., Barlera, Simona, Franzosi, Maria Grazia, Porcu, Maurizio, Yusuf, Salim, Camerini, Fulvio, Cohn, Jay N., Decarli, Adriano, Pitt, Bertram, Sleight, Peter, Poole-Wilson, Philip A., Geraci, Enrico, Scherillo, Marino, Fabbri, Gianna, Bartolomei, Barbara, Bertoli, Daniele, Cobelli, Franco, Fresco, Claudio, Ledda, Antonietta, Levantesi, Giacomo, Opasich, Cristina, Rusconi, Franco, Sinagra, Gianfranco, Turazza, Fabio, Volpi, Alberto, Ceseri, Martina, Alongi, Gianluca, Atzori, Antonio, Bambi, Filippo, Bastarolo, Desiree, Bianchini, Francesca, Cangioli, Iacopo, Canu, Vittoriana, Caporusso, Concetta, Cenni, Gabriele, Cintelli, Laura, Cocchio, Michele, Confente, Alessia, Fenicia, Eva, Friso, Giorgio, Gianfriddo, Marco, Grilli, Gianluca, Lazzaro, Beatrice, Lonardo, Giuseppe, Luise, Alessia, Nota, Rachele, Orlando, Mariaelena, Petrolo, Rosaria, Pierattini, Chiara, Pierota, Valeria, Provenzani, Alessandro, Quartuccio, Velia, Ragno, Anna, Serio, Chiara, Spolaor, Alvise, Tafi, Arianna, Tellaroli, Elisa, Ghio, Stefano, Ghizzardi, Elisa, Masson, Serge, Crociati, Lella, La Rovere, Maria Teresa, Corrà, Ugo, Di Giulio, Paola, Finzi, Andrea, Gorini, Marco, Milani, Valentina, Orsini, Giampietro, Bianchini, Elisa, Cabiddu, Silvia, Cangioli, Ilaria, Cipressa, Laura, Cipressa, Maria Lucia, Di Bitetto, Giuseppina, Ferri, Barbara, Galbiati, Luisa, Lorimer, Andrea, Pera, Carla, Priami, Paola, and Vasamì, Antonella

Subjects
Blood Glucose, Male, Glycated Hemoglobin A, heart failure, Kaplan-Meier Estimate, prediabetes, 030204 cardiovascular system & hematology, time factors, Settore MED/11, cause of death, 0302 clinical medicine, Glycemic control, prediabetic state, Cause of Death, italy, middle aged, Prevalence, 80 and over, double-blind method, blood glucose, risk factors, 030212 general & internal medicine, Prediabetes, Rosuvastatin Calcium, humans, rosuvastatin calcium, Cause of death, Original Research, Metabolic Syndrome, Aged, 80 and over, adult, Chronic heart failure, Diabetes mellitus, Heart failure, Mortality, Cardiology and Cardiovascular Medicine, Hazard ratio, chronic heart failure, diabetes mellitus, glycemic control, mortality, Treatment Outcome, Adolescent, Biomarkers, Chronic Disease, Diabetes Mellitus, Fatty Acids, Omega-3, Double-Blind Method, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hospitalization, Heart Failure, Italy, Prediabetic State, Risk Assessment, Proportional Hazards Models, Risk Factors, Time Factors, risk assessment, Middle Aged, kaplan-meier estimate, aged, female, Prediabete, young adult, Female, omega-3, Human, hospitalization, Adult, medicine.medical_specialty, Diabetes mellitu, proportional hazards models, Time Factor, hydroxymethylglutaryl-coa reductase inhibitors, prevalence, fatty acids, 03 medical and health sciences, Young Adult, male, Internal medicine, Post-hoc analysis, glycated hemoglobin a, medicine, Intensive care medicine, Aged, Glycated Hemoglobin, Proportional hazards model, business.industry, Risk Factor, biomarkers, Biomarker, medicine.disease, Clinical trial, adolescent, Proportional Hazards Model, treatment outcome, aged, 80 and over, chronic disease, fatty acids, omega-3, cardiology and cardiovascular medicine, Hydroxymethylglutaryl-CoA Reductase Inhibitor, business
Abstract

Background The independent prognostic impact of diabetes mellitus ( DM ) and prediabetes mellitus (pre‐ DM ) on survival outcomes in patients with chronic heart failure has been investigated in observational registries and randomized, clinical trials, but the results have been often inconclusive or conflicting. We examined the independent prognostic impact of DM and pre‐ DM on survival outcomes in the GISSI ‐HF (Gruppo Italiano per lo Studio della Sopravvivenza nella Insufficienza Cardiaca‐Heart Failure) trial. Methods and Results We assessed the risk of all‐cause death and the composite of all‐cause death or cardiovascular hospitalization over a median follow‐up period of 3.9 years among the 6935 chronic heart failure participants of the GISSI ‐ HF trial, who were stratified by presence of DM (n=2852), pre‐ DM (n=2013), and non‐ DM (n=2070) at baseline. Compared with non‐ DM patients, those with DM had remarkably higher incidence rates of all‐cause death (34.5% versus 24.6%) and the composite end point (63.6% versus 54.7%). Conversely, both event rates were similar between non‐ DM patients and those with pre‐ DM . Cox regression analysis showed that DM , but not pre‐ DM , was associated with an increased risk of all‐cause death (adjusted hazard ratio, 1.43; 95% CI , 1.28–1.60) and of the composite end point (adjusted hazard ratio, 1.23; 95% CI , 1.13–1.32), independently of established risk factors. In the DM subgroup, higher hemoglobin A1c was also independently associated with increased risk of both study outcomes (all‐cause death: adjusted hazard ratio, 1.21; 95% CI , 1.02–1.43; and composite end point: adjusted hazard ratio, 1.14; 95% CI , 1.01–1.29, respectively). Conclusions Presence of DM was independently associated with poor long‐term survival outcomes in patients with chronic heart failure. Clinical Trial Registration URL : http://www.clinicaltrials.gov . Unique identifier: NCT 00336336.

Published
2017

324. The EuroSciCon's 2015 Innate Immunity Summit

Author

Claudia Matteucci, Raquel Guillamat-Prats, Francesco Peri, Áine McKnight, Marta Camprubí-Rimblas, Camprubí Rimblas, M, Peri, F, Mcknight, Á, Matteucci, C, and Guillamat Prats, R

Subjects
0301 basic medicine, Intrinsic immunity, Inflammation, restriction factor, Biology, Virus, 03 medical and health sciences, Classical complement pathway, Immune system, Toll-like receptor, Virology, CHIM/06 - CHIMICA ORGANICA, medicine, innate immunity, complement system, Innate immune system, macrophages (M1/M2), Innate lymphoid cell, Acquired immune system, 030104 developmental biology, CHIM/08 - CHIMICA FARMACEUTICA, thymosin α-1, Immunology, medicine.symptom, T cells (Th1/Th2)
Abstract

The EuroSciCon's 2015 Innate Immunity Summit, London, UK, 17–19 November 2015 A first line of defense against viral infection is prompted by the innate immune system. Viruses activate both extracellular and intracellular events that lead to a war between the virus and the host. In addition to vaccines which induce adaptive T- and B-cell response in readiness for infection, other therapies that potentiate the host immune response are in development, such as those that induce an increase in restriction factor activity or diminish inflammation through Toll-like receptors’ antagonists. Other modulators of immune response, such as thymosin α-1, contribute to the inhibition of HIV-1 and human T lymphotropic virus 1 infection. Understanding the mechanisms by which the innate immune response combats pathogen invasion will enable the generation of novel therapeutic strategies to cure viral infection.

Published
2016

325. Earliest evidence of proto-dental treatment in the late Upper Paleolithic

Author

Gregorio Oxilia, Marco Peresani, Matteo Romandini, Chiara Matteucci, Cynthianne Debono Spiteri, Henry, Amanda G., Dieter Schulz, Will Archer, Jacopo Crezzini, Francesco Boschin, Paolo Boscato, Klervia Jaouen, Tamara Dogandzic, Alberto Broglio, Jacopo Moggi-Cecchi, Luca Fiorenza, Jean-Jacques Hublin, Ottmar Kullmer, Stefano Benazzi, Oxilia, G., Peresani, M., Romandini, M., Matteucci, C., Debono Spiteri, C., Henry, A.G., Schulz, D., Archer, W., Crezzini, J., Boschin, F., Boscato, P., Jaouen, K., Dogandžić, T., Broglio, A., Moggi Cecchi, J., Fiorenza, L., Hublin, J.J., Kullmer, O., and Benazzi, S.

Subjects
stomatognathic diseases, stomatognathic system, Prehistoric dental treatments, Riparo Villabruna, Late Upper Paleolithic, Taphonomy, Socio-culturale
Abstract

Prehistoric dental treatments have been known from the Neolithic 9,000-7,500 years before present (BP) [1], when the adoption of early farming culture caused an increase of carious lesions [2]. Only a few early cases have been documented [3], some were characterized by in vivo perforation of the crown surface made by a drilling tool [1]. Here we document the earliest evidence of proto-dental therapeutic intervention on a Late Upper Paleolithic modern human lower right third molar (RM3) from a burial in Northern Italy [4]. The RM3 belongs to a young male individual (ca. 25 years old) unearthed in 1988 from the Epigravettian deposit of Riparo Villabruna (Sovramonte – Belluno, Italy), and dated around 14,160-13,820 BP. This tooth presents a large occlusal cavity, with a polished internal surface and extensive enamel chipping traces on the steep mesial wall. Within the cavity four caries are present. The cavity is sub-squared on the lingual and mesial sides but rounded on the buccal and distal sides. Using Scanning Electron Microscopy (SEM) we show the presence of striations within the cavity, which fade out towards the occlusal surface probably as a consequence of tooth wear. The striations have a ”V” shaped transverse section and microstriations at the bottom, sharply defined, with a high apex, steep sides, narrow cross-sections and well-defined parallel ancillary ridging, as typically displayed by cutmarks on teeth [5]. Based on in vitro experimental replication and a complete functional reconstruction of the Villabruna dental arches, we confirm that the identified striations and the associated extensive enamel chipping on the mesial wall of the cavity were produced ante-mortem by pointed flint tools during scratching and chiseling activities. The Villabruna specimen is therefore the oldest known evidence of dental caries intervention, suggesting rudimentary knowledge of disease treatment well before the Neolithic. This study also suggests that primitive forms of carious treatment in human evolution entail an adaptation of the well-known toothpickings for levering and scratching rather than drilling practices.

Published
2015

326. The GNAS1 gene in myelodysplastic syndromes (MDS)

Author

Barbara Crescenzi, Tiziana Pierini, Danika Di Giacomo, Nicoletta Testoni, Anair Graciela Lema Fernandez, Lucia Brandimarte, Caterina Matteucci, Cristina Mecucci, Di Giacomo, D., Lema Fernandez, A.G., Pierini, T., Crescenzi, B., Brandimarte, L., Matteucci, C., Testoni, N., and Mecucci, C.

Subjects
Male, Cancer Research, del(20q)/20q−, Myelodysplastic Syndrome, Chromosomes, Human, Pair 20, Biology, Long arm, hemic and lymphatic diseases, GNAS complex locus, medicine, MDS, Chromogranins, GTP-Binding Protein alpha Subunits, Gs, Humans, Gene, In Situ Hybridization, Fluorescence, Aged, Genetics, Myelodysplastic syndromes, Karyotype, Hematology, Gene deletion, medicine.disease, Activating mutation, Oncology, GNAS1, GTP-Binding Protein alpha Subunits, G, Myelodysplastic Syndromes, Haplo-insufficiency, Mutation, biology.protein, Female, Chromosome 20, Gene Deletion, Human
Abstract

GNAS1 gene is located at the long arm of chromosome 20 (q13.32). GNAS1 gene deletion has never been investigated in MDS. A GNAS1 activating mutation (R201) was recently found in MDS. We applied FISH and DHPLC plus sequencing to investigate GNAS1 gene in MDS cases with and without del(20q) at karyotype.

Published
2014

327. Effects of granulocyte-monocyte colony-stimulating factor (GM-CSF) on expression of adhesion molecules and production of cytokines in blood monocytes and ovarian cancer-associated macrophages

Author

Nicoletta Colombo, Paola Allavena, Monica Mosca, Christian Matteucci, Sergio Bernasconi, Mario Conni, Marina Sironi, Cristina Bonazzi, Fabio Landoni, Francesco Colotta, Giuseppe Corbetta, Alberto Mantovani, Bernasconi, S, Matteucci, C, Sironi, M, Conni, M, Colotta, F, Mosca, M, Colombo, N, Bonazzi, C, Landoni, F, and Corbetta, G

Subjects
Cytotoxicity, Immunologic, Cancer Research, medicine.medical_specialty, Macrophage, MED/40 - GINECOLOGIA E OSTETRICIA, medicine.medical_treatment, Adenocarcinoma, Biology, Monocyte, Monocytes, Ovarian tumor, Internal medicine, medicine, Humans, Cytokine, Ovarian Neoplasms, Cell adhesion molecule, Ovarian Neoplasm, Macrophages, Granulocyte-Macrophage Colony-Stimulating Factor, Mononuclear phagocyte system, Macrophage Activation, Flow Cytometry, Endocrinology, medicine.anatomical_structure, Granulocyte macrophage colony-stimulating factor, Oncology, Cell Adhesion Molecule, Cancer research, Cytokines, Female, Tumor necrosis factor alpha, Cell Adhesion Molecules, medicine.drug
Abstract

The present study was aimed at characterizing the effects of in vitro exposure to GM-CSF on blood monocytes and tumor-associated macrophages (TAM) in human ovarian cancer. Purified populations of TAM from ovarian cancer patients were studied in terms of expression of surface molecules, cytokine production and tumor cytotoxicity after overnight incubation with GM-CSF or IFN gamma and LPS, used as reference activators. GM-CSF augmented the surface expression of ICAM-I and CD18 in TAM and in blood monocytes. Stimulation was more prominent in monocytes than in TAM, which showed higher baseline expression of this adhesion molecule. ICAM-3 was not influenced by GM-CSF or by IFN gamma/LPS. GM-CSF-augmented ICAM-I expression was associated with higher levels of mRNA transcripts. The protein synthesis inhibitor cycloheximide super-induced basal and GM-CSF-induced ICAM-I transcripts, thus excluding a role for secondary polypeptide mediators. In the absence of stimuli, TAM produced higher levels, compared to monocytes, of IL-6 and IL-8 but not of IL-1 and TNF. GM-CSF augmented the production of IL-6 and IL-8 (but not that of IL-1 and TNF) in TAM, whereas it had little effect on blood monocyte. Tumoricidal activity was tested against two ovarian tumor cell lines (OVCAR3 and SW626). GM-CSF more prominently augmented monocyte cytotoxicity, while only 2 of 6 TAM preparations were stimulated by GM-CSF. These results suggest that GM-CSF selectively regulates the function of blood monocytes and TAM, the effect of this cytokine varying with the parameter and cell population examined. These data provide a rational and biological endpoint for further studies with GM-CSF as an activator of mononuclear phagocyte function in ovarian cancer.

Published
1995

328. Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-azacytidine

Author

G. Fioritoni, Carlo Finelli, Santini, Lucia Brandimarte, Mariangela Greco, Caterina Matteucci, Pellegrino Musto, Maria Teresa Voso, Christina Mecucci, Alfonso Piciocchi, Stefan Hohaus, Giuseppe Leone, Emanuele Angelucci, Marco Vignetti, Marianna Criscuolo, Emiliano Fabiani, Enrico Pogliani, Luana Fianchi, Voso, M, Fabiani, E, Piciocchi, A, Matteucci, C, Brandimarte, L, Finelli, C, Pogliani, E, Angelucci, E, Fioritoni, G, Musto, P, Greco, C, Criscuolo, M, Fianchi, L, Vignetti, M, Santini, V, Hohaus, S, Mecucci, C, and Leone, G

Subjects
Male, Cancer Research, Antimetabolites, BCL2L10, TET2, 5-azacytidine, myelodysplastic syndromes, medicine.disease_cause, Retrospective Studie, MED/15 - MALATTIE DEL SANGUE, Risk Factors, Proto-Oncogene Proteins, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), ComputingMilieux_MISCELLANEOUS, Proto-Oncogene Protein, Mutation, Hematology, Methylation, Middle Aged, Prognosis, Antineoplastic, DNA-Binding Proteins, Survival Rate, Oncology, Proto-Oncogene Proteins c-bcl-2, DNA methylation, Azacitidine, Female, Human, medicine.drug, Adult, Antimetabolites, Antineoplastic, Prognosi, DNA-Binding Protein, Biology, Dioxygenases, medicine, Humans, Survival rate, Aged, Myelodysplastic Syndromes, Retrospective Studies, DNA Methylation, Risk Factor, Myelodysplastic syndromes, medicine.disease, Immunology, Cancer research, Settore MED/15 - Malattie del Sangue
Abstract

Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine

Published
2011

329. Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome

Author

Valentina Martelli, Claudia Lantadilla, Simona Moscatiello, Carlotta Matteucci, Maria Cristina Meriggiola, Sara Valisella, Giuseppe Pelusi, Giulio Marchesini, Antonietta Costantino, Martelli V., Valisella S., Moscatiello S., Matteucci C., Lantadilla Truffello C. A., Costantino A., Pelusi G., Marchesini G., and Meriggiola M.C.

Subjects
Adult, medicine.medical_specialty, Sexual Dysfunction, Urology, Endocrinology, Diabetes and Metabolism, Female sexual dysfunction, Population, Blood Pressure, FSD, Impaired glucose tolerance, Endocrinology, Risk Factors, Diabetes mellitus, Internal medicine, Surveys and Questionnaires, medicine, Prevalence, Humans, Trygliceride, Sexual Dysfunctions, Psychological, education, Aged, Gynecology, Metabolic Syndrome, education.field_of_study, business.industry, FSFI, Middle Aged, medicine.disease, Obesity, Postmenopause, Psychiatry and Mental health, Distress, Sexual Dysfunction, Physiological, Sexual dysfunction, Reproductive Medicine, Female, Metabolic syndrome, medicine.symptom, business
Abstract

Introduction The metabolic syndrome (MetS) is a multifactorial disease characterized by the co‐occurrence of impaired glucose tolerance/diabetes, central obesity, high levels of triglycerides, low levels of high‐density lipoprotein, and hypertension. Its prevalence is higher in menopausal women. We, and others, have recently shown that female sexual dysfunction (FSD) affects menopausal women. Whether the presence of MetS may be linked to a higher risk of FSD in menopausal women is unknown. Aims The aims of our study were: (i) to evaluate the prevalence of FSD in women with MetS (based on National Cholesterol Education program‐Adult Treatment Panel III 2009 criteria) in comparison with healthy controls and (ii) to evaluate the influence of singular components of MetS on female sexual function. Methods The Female Sexual Function Index (FSFI) questionnaire, the Female Sexual Distress Scale (FSDS), and The Middlesex Hospital Questionnaire were administered to 103 postmenopausal women with MetS and 105 healthy postmenopausal controls (HC). Female sexuality was defined as dysfunctional when FSFI score was 15. Main Outcome Measures FSFI and FSDS were completed by women with and without MetS. Results The prevalence of women with sexual dysfunction was higher in MetS women than HC (39/103 [37.9%] vs. 20/105 [19%], P = 0.003). The prevalence of both pathological scores in every FSFI domain and FSDS score was higher in MetS women than HC. The logistic regression, considering age and the length of relationship as a common starting point, shows that higher levels of triglycerides are linked to a higher risk of presenting FSD (odds ratio = 2.007 95% confidence interval [1.033–3.901]) in the whole population. Conclusions. Our preliminary results suggest that prevalence of FSD is higher in women with MetS in comparison with healthy controls. Higher levels of triglycerides are linked to a higher risk of presenting FSD. Martelli V, Valisella S, Moscatiello S, Matteucci C, Lantadilla C, Costantino A, Pelusi G, Marchesini G, and Meriggiola MC. Prevalence of sexual dysfunction among postmenopausal women with and without metabolic syndrome. J Sex Med 2012;9:434–441.

Published
2011

330. FISH analysis reveals frequent co-occurrence of 4q24/TET2 and 5q and/or 7q deletions

Author

Caterina Matteucci, Clelia Tiziana Storlazzi, Antonio Pierini, Nicoletta Testoni, Pellegrino Musto, Valentina Gianfelici, Roberta La Starza, Valeria Nofrini, Gianluca Barba, Paolo Gorello, Stefania Paolini, Barbara Crescenzi, Cristina Mecucci, Lucia Brandimarte, Valentina Pierini, Laura Berchicci, La Starza R., Crescenzi B., Nofrini V., Barba G., Matteucci C., Brandimarte L., Pierini V., Testoni N., Musto P., Paolini S., Gianfelici V., Storlazzi C.T., Pierini A., Berchicci L., Gorello P., and Mecucci C.

Subjects
Male, Cancer Research, Pathology, medicine.medical_specialty, Myeloid, Karyotypic abnormality, Biology, Dioxygenases, Mutation Rate, Proto-Oncogene Proteins, medicine, Humans, Del(4)(q24), Child, In Situ Hybridization, Fluorescence, Aged, Aged, 80 and over, Co-occurrence, Fish analysis, Hematology, TET2 gene, 5q−, Middle Aged, DNA-Binding Proteins, Haematopoiesis, Exact test, medicine.anatomical_structure, Oncology, Data Interpretation, Statistical, Hematologic Neoplasms, Karyotyping, %22">Fish , Chromosomes, Human, Pair 5, Female, Chromosome Deletion, Chromosomes, Human, Pair 4, Chromosomes, Human, Pair 7
Abstract

We investigated TET2 deletion in 418 patients with hematological malignancies. Overall interphase FISH detected complete or partial TET2 monoallelic deletion (TET2del) in 20/418 cases (4.7%). TET2del was very rare in lymphoid malignancies (1/242 cases; 0.4%). Among 19 positive myeloid malignancies TET2del was associated with a 4q24 karyotypic abnormality in 18 cases. In AML, TET2del occurred in CD34-positive hematopoietic precursors and preceded established genomic abnormalities, such as 5q− and −7/7q−, which were the most frequent associated changes (Fisher's exact test P = 0.000).

Published
2011

331. Introduzione

Author

CATTANEO, FRANCESCO, MARINO, STEFANO, GENTILI, CARLO, G. GREGORIO, S. MARINO, M. FAILLA, G. MATTEUCCI, C. GENTILI, F. ARENAS-DOLZ, D. KOCH, R.M. MARAFIOTI, A. CONTINI, F. CATTANEO, F. CATTANEO, C. GENTILI, S. MARINO, F. CATTANEO, S. MARINO, and C. GENTILI

Subjects
FILOSOFIA PRATICA, VERITÀ E METODO, ERMENEUTICA, HANS-GEORG GADAMER, DIALOGO
Abstract

Presentazione del volume, attraverso una contestualizzazione dell'iniziativa nell'ambito dello scenario filosofico contemporaneo e soprattutto nell'ambito degli studi su Gadamer.

Published
2011

332. Sul divino nel pensiero dell'evento di Martin Heidegger. Una replica alle osservazioni di Hans-Georg Gadamer

Author

CATTANEO, FRANCESCO, V. FERRARET, G. GREGORIO, S. MARINO, M. FAILLA, G. MATTEUCCI, C. GENTILI, F. ARENAS-DOLZ, D. KOCH, R.M. MARAFIOTI, A. CONTINI, F. CATTANEO, F. CATTANEO, C. GENTILI, S. MARINO, F. CATTANEO, and V. FERRARET

Subjects
TEOLOGIA, MARTIN HEIDEGGER, HANS-GEORG GADAMER, FRIEDRICH HÖLDERLIN, DIVINO
Abstract

Il saggio di Dietmar Koch tenta di spiegare come la tradizionale differenza tra fede e sapere, tra teologia cristiana e filosofia sia inadeguata a un discorso sul sacro, o meglio sul divino, che voglia risultare davvero confacente all'Altro inizio del pensiero teorizzato da Heidegger. In tal senso, le critiche mosse da Gadamer a Heidegger su questo punto appaiono viziate dalla riproposizione di categorie concettuali tradizionali, incapaci di cogliere l'indole specifica del discorso heideggeriano, pienamente coerente con la sua impostazione fenomenologica.

Published
2011

333. Spondyloepiphyseal dysplasia tarda: description of one case

Author

DI MOTTA, DANIELE, BERGAMASCHI, ROSALBA, CASTIGLIONI, LAURA, MATTEUCCI, CHIARA, Sudanese A, Di Motta D, Sudanese A, Bergamaschi R, Castiglioni L, and Matteucci C

Subjects
musculoskeletal diseases, Adult, Diagnosis, Differential, Male, Radiography, Foot, Humans, Hip Joint, DYSPLASIA, Osteochondrodysplasias, Spine
Abstract

The authors describe the case of an Italian male aged 19 years who came to their observation for severe limping with reduction in hip movement and spondyloepiphyseal radiographic modifications of an osteochondrodysplastic origin. The studies carried out led to a diagnosis of spondyloepiphyseal dysplasia tarda (SEDT).

Published
2006

334. Genomic gain at 6p21: a new cryptic molecular rearrangement in secondary myelodysplastic syndrome and acute myeloid leukemia

Author

Silvia Romoli, Anna Aventin, Barbara Crescenzi, Peter Marynen, Nicoletta Testoni, Caterina Matteucci, E. Di Bona, M F Martelli, R La Starza, Marina Lafage-Pochitaloff, Anna Locasciulli, Stefania Ciolli, Christina Mecucci, Valentina Pierini, Constantina Sambani, La Starza R, Aventin A, Matteucci C, Crescenzi B, Romoli S, Testoni N, Pierini V, Ciolli S, Sambani C, Locasciulli A, Di Bona E, Lafage-Pochitaloff M, Martelli MF, Marynen P, and Mecucci C.

Subjects
Adult, Male, Cancer Research, Biology, Sensitivity and Specificity, Translocation, Genetic, Fanconi anemia, hemic and lymphatic diseases, medicine, Secondary Acute Myeloid Leukemia, Humans, In Situ Hybridization, Fluorescence, Aged, Genetics, Aged, 80 and over, medicine.diagnostic_test, Myelodysplastic syndromes, Secondary Myelodysplastic Syndrome, Myeloid leukemia, Neoplasms, Second Primary, Hematology, Gene rearrangement, Middle Aged, medicine.disease, Oncology, Leukemia, Myeloid, Myelodysplastic Syndromes, Acute Disease, Cytogenetic Analysis, Chromosomes, Human, Pair 6, Female, Fluorescence in situ hybridization, Comparative genomic hybridization
Abstract

Fluorescence in situ hybridization and comparative genomic hybridization characterized 6p rearrangements in eight primary and in 10 secondary myeloid disorders (including one patient with Fanconi anemia) and found different molecular lesions in each group. In primary disorders, 6p abnormalities, isolated in six patients, were highly heterogeneous with different breakpoints along the 6p arm. Reciprocal translocations were found in seven. In the 10 patients with secondary acute myeloid leukemia/myelodysplastic syndrome (AML/MDS), the short arm of chromosome 6 was involved in unbalanced translocations in 7. The other three patients showed full or partial trisomy of the 6p arm, that is, i(6)(p10) (one patient) and dup(6)(p) (two patients). In 5/7 patients with unbalanced translocations, DNA sequences were overrepresented at band 6p21 as either cryptic duplications (three patients) or cryptic low-copy gains (two patients). In the eight patients with cytogenetic or cryptic 6p gains, we identified a common overrepresented region extending for 5-6 megabases from the TNF gene to the ETV-7 gene. 6p abnormalities were isolated karyotype changes in four patients. Consequently, in secondary AML/MDS, we hypothesize that 6p gains are major pathogenetic events arising from acquired and/or congenital genomic instability.

Published
2006

336. Expression of a long pentraxin, PTX3, by monocytes exposed to the mycobacterial cell wall component lipoarabinomannan

Author

Cristian Matteucci, Giuseppe Peri, Martino Introna, Alberto Mantovani, Guido Poli, Valérie Vouret-Craviari, Vouretcraviari, V, Matteucci, C, Peri, G, Poli, Guido, Introna, M, and Mantovani, A.

Subjects
Lipopolysaccharides, medicine.medical_treatment, Immunology, Microbiology, Peripheral blood mononuclear cell, Monocytes, Proinflammatory cytokine, Mycobacterium, medicine, Humans, Cells, Cultured, Antigens, Bacterial, Lipoarabinomannan, Pentraxins, biology, Monocyte, PTX3, Serum Amyloid P-Component, Infectious Diseases, medicine.anatomical_structure, Cytokine, C-Reactive Protein, Gene Expression Regulation, biology.protein, Parasitology, Tumor necrosis factor alpha, Research Article
Abstract

PTX3 is a prototypic long pentraxin composed of a C-terminal domain similar to those of classical pentraxins (e.g., C reactive protein) and an unrelated N-terminal portion. PTX3 is expressed in a variety of cell types, notably mononuclear phagocytes and endothelial cells, after exposure to the inflammatory cytokines interleukin-1beta (IL-1beta) and tumor necrosis factor alpha (TNF-alpha). The present study was designed to assess whether mycobacterial components were able to induce expression and production of PTX3. Mycobacterial lipoarabinomannan (LAM) induced expression of PTX3 mRNA in human peripheral blood mononuclear cells. The non-mannose-capped version of lipoarabinomannan (AraLAM) was considerably more potent than the mannose-capped version ManLAM or the simpler version phosphatidylinositol mannoside. Among mononuclear cells, monocytes were responsible for LAM-induced PTX3 mRNA expression. Whole mycobacteria (Mycobacterium bovis BCG) strongly induced PTX3 expression. Pretreatment with actinomycin D abolished LAM-induced PTX3 expression, whereas cycloheximide only partially reduced the expression. LAM-induced PTX3 expression was associated with the production of immunoreactive PTX3. IL-10 and IL-13 did not inhibit the induction of PTX3 by LAM. Under the same conditions, these anti-inflammatory cytokines inhibited MCP-1 expression. In contrast, gamma interferon inhibited LAM-induced PTX3 expression. Thus, in addition to IL-1, TNF, and lipopolysaccharide, mycobacterial cell wall components also induce expression and production of the long pentraxin PTX3. The significance of PTX3 in the immunobiology of mycobacterial infection and its relevance in relation to clinical involvement remain to be determined.

Published
1997

337. TERT Gene Promoter Mutations In Myelodysplastic Syndromes (MDS)

Author

Antonella Sgura, Tamara Iannotti, Gianluca Barba, Caterina Matteucci, Valeria Di Battista, Francesco Berardinelli, Filomena Nozza, Cristina Mecucci, Lucia Brandimarte, Valeria Nofrini, Matteucci, C, Iannotti, T, Brandimarte, L, Nofrini, V, Barba, G, Sgura, Antonella, Berardinelli, Francesco, Nozza, F, Di Battista, V, and Mecucci, C.

Subjects
Sanger sequencing, Chromosome 7 (human), Point mutation, Immunology, Nonsense mutation, Cell Biology, Hematology, Biology, Compound heterozygosity, Biochemistry, Molecular biology, symbols.namesake, Germline mutation, Gene duplication, symbols, Missense mutation
Abstract

Mutations at the protein-coding region of TERT gene (chromosome 5p15.33) have been well characterized in patients affected by a constitutional telomere syndrome, including diskeratosis, aplastic anemia and pulmonary fibrosis (Calado RT, Hematology, ASH 2009:338). In rare cases somatic mutations may occur in de novo MDS/AML (Calado RT, Young NS. Blood 2008;111:4446). Mutations involving the regulatory region of TERT gene have been recently identified in a consistent proportion of familial and sporadic melanoma and in a subset of tumors originating from tissues with low rate of self-renewal (glioblastoma, liposarcoma, oligodendroglioma bladder cancer, upper urinary tract cancer). These mutations create new binding motifs for Ets/TCF transcription factors, thus increasing TERT gene transcription (Killela PJ et al, PNAS 2013;110:6021; Horn S et al, Science 2013;339:959). As far as we know TERT promoter mutations were never described in MDS. Material and Methods Index Case. A 52 years old woman was selected because of a complex phenotype including abnormal skin pigmentation, familial pulmonary fibrosis, osteoarthritis, and a refractory cytopenia with multilineage dysplasia (RCMD, WHO 2008) with a 47,XX,+8 karyotype. Screening Cases. Mutational analysis was extended to a cohort of 115 patients (72 males; 44 females, median age 69) referred to the Laboratory of Cytogenetics, Hematology Department,University of Perugia, Italy. Cytogenetics was normal in 49 cases (43%). Abnormalities included: isolated del(5q) (seven cases, 6%); del(5q) plus one additional change (three cases, 3%); isolated del(20q) (fourteen cases, 12%); trisomy 8 (five cases, 4%); monosomy 7 (two cases, 2%); -Y (three cases, 3%); del(11q) (two cases, 2%); complex karyotype (twenty-four cases, 21%); other aberrations (six cases, 5%). Genomic DNA was extracted from bone marrow (BM) of all cases and from peripheral blood T lymphocytes of index case using Salting out method. In all cases TERT promoter was screened using PCR based DHPLC assay (Wave system; MD Transgenomic Inc. Omaha, NE). The 274bp amplicon was amplified with forward primer 5'GTCCTGCCCCTTCACCTTC3' and reverse primer 5'AGCACCTCGCGGTAGTGG3' using Robust Start Taq KAPA2G (Biosystems, Woburn, MA). DNA from abnormal elution profiles were re-amplified and sequenced by Sanger method (ABI 3500 Genetic Analyzer, Applied Biosystems). Variations were detected using Finch TV v. 1.4.0. In the index case 23 amplicons encompassing all 16 exons of TERT gene were also screened (NC_000005.9). Mutations cloning was carried out after RNA extraction (Trizol, Invitrogen, Life Technologies, Paisley, UK), reverse transcription (ThermoscriptTM RT-PCR System, Invitrogen) and amplification (TERT_2CF (5'-CAGCGCTACTGGCAAATGCG-3' Ta-61,4°C; and TERT_2543R (5'-GGCACTGGACGTAGGACTTG-3' Ta-61,4°C). PCR products were sub-cloned into pGEM-T easy vector (Promega, Madison, WI, USA) and sequenced. Results Index Case. Patient was a compound heterozygous for two germline variations: a nonsense mutation c.1209C>A p.C403* (exon 2) and a missense mutation c.2455C>T p.R819C (exon 8). A putative somatic A>C transition 57 bp before the ATG start codon was detected only in BM cells (Table). Screening Cases. DHPLC analysis showed three patients (2.6%) with a two-peak elution profile. Sequencing revealed a 10 bp duplication (c.1-110_1-101) in case 2; a c.1-124 C>T point mutation in case 3; a point mutation c.1-78 C>T in case 4 (Table). Comment We showed that TERT gene promoter variations are recurrent events in 2.6% of MDS patients. Only low/int1 risk MDS (IPSS) were affected in this series. The c.1-57A>C, previously reported as a germline activating variation in familial melanoma (Horn S et al, Science 2013;339:959), was likely a somatic mutation in our index case, thus supporting its role in clonal MDS proliferation. We first found the melanoma activating c.1-124 C>T point mutation (Huang FW et al, Science 2013;339:957; Killela PJ et al, PNAS 2013;110:6021) in a MDS with isolated del(5q). The new variation of our case n.4 does not appear to introduce a new transcription factor binding site (http://www.cbrc.jp/research/db/TFSEARCH.html), whereas the 10bp duplication of case 2 indicates an hypothetical binding site for Ikaros. Further results from ongoing functional studies in these cases will be presented. Disclosures: No relevant conflicts of interest to declare.

Published
2013

340. Questioni di identità e forma nella pittura di accademia

Author

Donatella BIAGI, M. Gregori, E. Riccòmini, A. Emiliani, O. Bonfait, D. Benati, A. M. Matteucci, C. Bernardini, E. Berselli, CARLA BERNARDINI, and D. Biagi Maino

Subjects
STUDI DI CARATTERE, INCISIONE, SETTECENTO, DIDATTICA ACCADEMICA, PITTURA
Abstract

Roberto Longhi e la pittura del Settecento a Bologna: la riscoperta dell'autonomia e della qualità della pittura di Crespi, Creti, dei Gandolfi, dei caratteri di internazionalità della scuola locale anche nelle peculiarità di generi specifici quali la quadratura. Indagine su un inedito album di incisioni da Annibale Carracci e risposta degli artisti citati alle sollecitazioni dei modelli alti dal Seicento reinventati per il secolo dei lumi.

342. Crosstalk between human endogenous retroviruses and exogenous viruses.

Author

Pizzioli E, Minutolo A, Balestrieri E, Matteucci C, Magiorkinis G, and Horvat B

Abstract

Human endogenous retroviruses (HERVs) are remnants of ancient retroviral infections of human germ-line cells, which are mostly silenced during evolution, but could be de-repressed and play a pathological role. Infection with some exogenous viruses, including herpesviruses, HIV-1 and SARS-CoV-2, was demonstrated to induce the expression of HERV RNAs and proteins., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Masson SAS.. All rights reserved.)

Published
2024
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343. Novel formulations for developing fresh hybrid cheese analogues utilizing fungal-fermented brewery side-stream flours.

Author

Palatzidi A, Nikoloudaki O, Torreiro MG, Matteucci C, Ferrentino G, Scampicchio MM, Di Cagno R, and Gobbetti M

Abstract

This study investigated the development of hybrid cheese analogues (HCA) made with fermented brewery side-stream ingredients (spent yeast and malt rootlets) and dairy milk. Different percentages of side-stream flours (3.5%, 5%, and 7.5%) were mixed with pasteurized milk, and the developed HCA were evaluated for their biochemical and textural properties. The addition of a fermentation step improved nutrient availability and led to pH (range 4.79-5.60) and moisture content (range 45.86%-61.29%) similar to traditional animal-based fresh cheeses (control). The inclusion of side-stream flours led to coagulation, even without rennet addition. The higher the concentration of the flour used, the faster the coagulation time, suggesting synergistic effect between the enzymes of the rennet and the enzymes present in the fermented side-stream flours. Nevertheless, textural properties were inferior compared to the control. Selected HCA formulations with added 3.5% flour exhibited increased counts of enterococci and enterobacteria cell densities, ranging from 7.28 ± 0.03 to 7.72 ± 0.09 log CFU/g and 4.90 ± 0.16 to 5.41 ± 0.01 log CFU/g, respectively. Compared to the control sample, HCA formulations exhibited higher concentrations of organic acids, peptides, and free amino acids (FAAs). Lactic acid reached up to 23.78 ± 0.94 g/kg of dry matter (DM), while the peptide area reached up to 22918.50 ± 2370.93 mL⋅AU. Additionally, the total concentration of individual FAAs reached up to 2809.74 ± 104.85 mg/kg of DM, contrasted with the control, which resulted in lower concentrations (847.65 ± 0.02 mg/kg of DM). The overall findings suggested that despite challenges in microbiological quality and textural properties, HCA produced with the inclusion of up to 3.5% brewery side-stream flours could be a sustainable solution to produce nutritious dairy alternatives., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors. Published by Elsevier B.V.)

Published
2024
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344. Phenotypic drug discovery: a case for thymosin alpha-1.

Author

Garaci E, Paci M, Matteucci C, Costantini C, Puccetti P, and Romani L

Abstract

Phenotypic drug discovery (PDD) involves screening compounds for their effects on cells, tissues, or whole organisms without necessarily understanding the underlying molecular targets. PDD differs from target-based strategies as it does not require knowledge of a specific drug target or its role in the disease. This approach can lead to the discovery of drugs with unexpected therapeutic effects or applications and allows for the identification of drugs based on their functional effects, rather than through a predefined target-based approach. Ultimately, disease definitions are mostly symptom-based rather than mechanism-based, and the therapeutics should be likewise. In recent years, there has been a renewed interest in PDD due to its potential to address the complexity of human diseases, including the holistic picture of multiple metabolites engaging with multiple targets constituting the central hub of the metabolic host-microbe interactions. Although PDD presents challenges such as hit validation and target deconvolution, significant achievements have been reached in the era of big data. This article explores the experiences of researchers testing the effect of a thymic peptide hormone, thymosin alpha-1, in preclinical and clinical settings and discuss how its therapeutic utility in the precision medicine era can be accommodated within the PDD framework., Competing Interests: The authors declare that EG, CC, and LR are involved in the “A phase II trial to assess the activity and tolerability of Thymosin alpha 1 in Cystic Fibrosis Patients” EudraCT Number: 2019-001441-40, sponsored by SciClone. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision., (Copyright © 2024 Garaci, Paci, Matteucci, Costantini, Puccetti and Romani.)

Published
2024
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345. A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias.

Author

Mavridou E, Lema Fernandez AG, Nardelli C, Pierini V, Quintini M, Arniani S, Di Giacomo D, Crescenzi B, Matteucci C, Sambani C, and Mecucci C

Subjects
Adult, Aged, Female, Humans, Male, Middle Aged, Chromosomes, Human, Pair 21 genetics, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute pathology, Mutation, Core Binding Factor Alpha 2 Subunit genetics, Myelodysplastic Syndromes genetics, Myelodysplastic Syndromes pathology, Proto-Oncogene Proteins genetics, Repressor Proteins genetics, Translocation, Genetic
Abstract

In myeloid neoplasms, both fusion genes and gene mutations are well-established events identifying clinicopathological entities. In this study, we present a thus far undescribed t(X;21)(p11.4;q22.12) in five cases with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML). The translocation was isolated or accompanied by additional changes. It did not generate any fusion gene or gene deregulation by aberrant juxtaposition with regulatory sequences. Molecular analysis by targeted next-generation sequencing showed that the translocation was accompanied by at least one somatic mutation in TET2, EZH2, RUNX1, ASXL1, SRSF2, ZRSR2, DNMT3A, and NRAS genes. Co-occurrence of deletion of RUNX1 in 21q22 and of BCOR in Xp11 was associated with t(X;21). BCOR haploinsufficiency corresponded to a significant hypo-expression in t(X;21) cases, compared to normal controls and to normal karyotype AML. By contrast, RUNX1 expression was not altered, suggesting a compensatory effect by the remaining allele. Whole transcriptome analysis showed that overexpression of HOXA9 differentiated t(X;21) from both controls and t(8;21)-positive AML. In conclusion, we characterized a new recurrent reciprocal t(X;21)(p11.4;q22.12) chromosome translocation in MDS and AML, generating simultaneous BCOR and RUNX1 deletions rather than a fusion gene at the genomic level., (© 2024 The Authors. Genes, Chromosomes and Cancer published by Wiley Periodicals LLC.)

Published
2024
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347. Persistence of circulating CD169+monocytes and HLA-DR downregulation underline the immune response impairment in PASC individuals: the potential contribution of different COVID-19 pandemic waves.

Author

Fanelli M, Petrone V, Maracchioni C, Chirico R, Cipriani C, Coppola L, Malagnino V, Teti E, Sorace C, Zordan M, Vitale P, Iannetta M, Balestrieri E, Rasi G, Grelli S, Malergue F, Sarmati L, Minutolo A, and Matteucci C

Abstract

The use of CD169 as a marker of viral infection has been widely discussed in the context of COVID-19, and in particular, its crucial role in the early detection of SARS-CoV-2 infection and its association with the severity and clinical outcome of COVID-19 were demonstrated. COVID-19 patients show relevant systemic alteration and immunological dysfunction that persists in individuals with post-acute sequelae of SARS-CoV-2 infection (PASC). It is critical to implement the characterization of the disease, focusing also on the possible impact of the different COVID-19 waves and the consequent effects found after infection. On this basis, we evaluated by flow cytometry the expression of CD169 and HLA-DR on monocytes from COVID-19 patients and PASC individuals to better elucidate their involvement in immunological dysfunction, also evaluating the possible impact of different pandemic waves. The results confirm CD169 RMFI is a good marker of viral infection. Moreover, COVID-19 patients and PASC individuals showed high percentage of CD169+ monocytes, but low percentage of HLA-DR+ monocytes and the alteration of systemic inflammatory indices. We have also observed alterations of CD169 and HLA-DR expression and indices of inflammation upon different COVID-19 waves. The persistence of specific myeloid subpopulations suggests a role of CD169+ monocytes and HLA-DR in COVID-19 disease and chronic post-infection inflammation, opening new opportunities to evaluate the impact of specific pandemic waves on the immune response impairment and systemic alterations with the perspective to provide new tools to monitoring new variants and diseases associated to emerging respiratory viruses., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Marialaura Fanelli reports financial support was provided by HERVCOV project funded by the HORIZONHLTH-2021-DISEASE G.A.101057302. Vita Petrone reports financial support was provided by HERVCOV project funded by the HORIZONHLTH-2021-DISEASE G.A.101057302. Chiara Cipriani reports financial support was provided by HERVCOV project funded by the HORIZONHLTH-2021-DISEASE G.A.101057302. Fabrice Malergue reports financial support was provided by Beckman Coulter LS., (© 2023 The Authors.)

Published
2023
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348. Preliminary Evidence of the Differential Expression of Human Endogenous Retroviruses in Kawasaki Disease and SARS-CoV-2-Associated Multisystem Inflammatory Syndrome in Children.

Author

Balestrieri E, Corinaldesi E, Fabi M, Cipriani C, Giudice M, Conti A, Minutolo A, Petrone V, Fanelli M, Miele MT, Andreozzi L, Guida F, Filice E, Meli M, Grelli S, Rasi G, Toschi N, Torcetta F, Matteucci C, Lanari M, and Sinibaldi-Vallebona P

Subjects
Humans, Child, SARS-CoV-2 genetics, Interleukin-10 genetics, Pilot Projects, COVID-19 genetics, Endogenous Retroviruses genetics, Mucocutaneous Lymph Node Syndrome genetics
Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious sequela of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with some clinical features overlapping with Kawasaki disease (KD). Our research group and others have highlighted that the spike protein of SARS-CoV-2 can trigger the activation of human endogenous retroviruses (HERVs), which in turn induces inflammatory and immune reactions, suggesting HERVs as contributing factors in COVID-19 immunopathology. With the aim to identify new factors involved in the processes underlying KD and MIS-C, we analysed the transcriptional levels of HERVs, HERV-related genes, and immune mediators in children during the acute and subacute phases compared with COVID-19 paediatric patients and healthy controls. The results showed higher levels of HERV-W, HERV-K, Syn-1, and ASCT-1/2 in KD, MIS-C, and COV patients, while higher levels of Syn-2 and MFSD2A were found only in MIS-C patients. Moreover, KD and MIS-C shared the dysregulation of several inflammatory and regulatory cytokines. Interestingly, in MIS-C patients, negative correlations have been found between HERV-W and IL-10 and between Syn-2 and IL-10, while positive correlations have been found between HERV-K and IL-10. In addition, HERV-W expression positively correlated with the C-reactive protein. This pilot study supports the role of HERVs in inflammatory diseases, suggesting their interplay with the immune system in this setting. The elevated expression of Syn-2 and MFSD2A seems to be a distinctive trait of MIS-C patients, allowing to distinguish them from KD ones. The understanding of pathological mechanisms can lead to the best available treatment for these two diseases, limiting complications and serious outcomes.

Published
2023
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350. Antioxidant Phytocomplexes Extracted from Pomegranate ( Punica granatum L.) Using Hydrodynamic Cavitation Show Potential Anticancer Activity In Vitro.

Author

Minutolo A, Gismondi A, Chirico R, Di Marco G, Petrone V, Fanelli M, D'Agostino A, Canini A, Grelli S, Albanese L, Centritto M, Zabini F, Matteucci C, and Meneguzzo F

Abstract

Hydrodynamic cavitation (HC), as an effective, efficient, and scalable extraction technique for natural products, could enable the affordable production of valuable antioxidant extracts from plant resources. For the first time, whole pomegranate ( Punica granatum L.) fruits, rich in bioactive phytochemicals endowed with anti-cancer properties, were extracted in water using HC. Aqueous fractions sequentially collected during the process (M1-M5) were lyophilized (L), filtered (A), or used as such, i.e., crude (C), and analyzed for their biochemical profile and in vitro antioxidant power. The fractions M3 and M4 from the L and C series showed the highest antiradical activity and phytochemical content. While the lyophilized form is preferable for application purposes, sample L-M3, which was produced faster and with lower energy consumption than M4, was used to assess the potential antiproliferative effect on human breast cancer line (AU565-PAR) and peripheral blood mononuclear (PBMC) cells from healthy donors. In a pilot study, cell growth, death, and redox state were assessed, showing that L-M3 significantly reduced tumor cell proliferation and intracellular oxygen reactive species. No effect on PBMCs was detected. Thus, the antioxidant phytocomplex extracted from pomegranate quickly (15 min), at room temperature (30 °C), and efficiently showed potential anticancer activity without harming healthy cells.

Published
2023
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