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252. The Histone Database: an integrated resource for histones and histone fold-containing proteins

Author

Andreas D. Baxevanis, David Landsman, Leonardo Mariño-Ramírez, Mario Morales, Kevin M. Levine, Suiyuan Zhang, and R. Travis Moreland

Subjects
Protein Folding, Protein Conformation, Database Updates, computer.software_genre, General Biochemistry, Genetics and Molecular Biology, Histones, Histone H1, Databases, Genetic, Histone methylation, Histone H2A, Histone code, Amino Acid Sequence, Histone octamer, Internet, Database, biology, Computational Biology, Proteins, Archaea, Histone, Histone methyltransferase, Histone fold, biology.protein, General Agricultural and Biological Sciences, computer, Software, Information Systems
Abstract

Eukaryotic chromatin is composed of DNA and protein components—core histones—that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and incorporation of diverse histone variants, can serve as epigenetic marks to control processes such as gene expression and recombination. The Histone Sequence Database is a curated collection of sequences and structures of histones and non-histone proteins containing histone folds, assembled from major public databases. Here, we report a substantial increase in the number of sequences and taxonomic coverage for histone and histone fold-containing proteins available in the database. Additionally, the database now contains an expanded dataset that includes archaeal histone sequences. The database also provides comprehensive multiple sequence alignments for each of the four core histones (H2A, H2B, H3 and H4), the linker histones (H1/H5) and the archaeal histones. The database also includes current information on solved histone fold-containing structures. The Histone Sequence Database is an inclusive resource for the analysis of chromatin structure and function focused on histones and histone fold-containing proteins. Database URL: The Histone Sequence Database is freely available and can be accessed at http://research.nhgri.nih.gov/histones/.

Published
2011

255. Efecto de la aplicación de columnas de anexina en los resultados reproductivos de parejas infértiles.

Author

Villa, Gerardo Barroso, Valenzuela, Alinne Colín, Velázquez, Mario Morales, Zazueta, Marcela Osuna, Trejo, Gonzalo Robledo, and Lombardo, Rosaura Ávila

Subjects
REPRODUCTIVE technology research, SEMEN analysis, OVUM, INFERTILITY, ANNEXINS, SPERM sorting
Abstract

Copyright of Ginecología y Obstetricia de México is the property of Federacion Mexicana de Ginecologia y Obstetricia and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2012

256. Esporotricosis micetomatoide con invasión a médula espinal.

Author

Gutiérrez Morales, José Luis, Moreno, Rogelio Domínguez, Esponda, Mario Morales, Rossiere Echazarreta, Natalia Lorena, Bonifant, Gerardo Reyes, and Ramírez, Alejandro Santos

Subjects
SPOROTRICHOSIS, SPINAL cord, PLEURAL effusions, CEREBROSPINAL fluid, PARAPLEGIA, MAGNETIC resonance imaging, MYCOSES
Published
2011

257. Estudio taxonómico de bacterias heterótrofas aisladas de aguas del Lago Peñuelas (V Región, Chile)

Author

Patricio Barrios, Ana del Moral, Manuel Saavedra, Bernardo Prado, and Mario Morales

Subjects
Bacillus (shape), biology, Aeromonas, General Earth and Planetary Sciences, biology.organism_classification, Molecular biology, General Environmental Science
Abstract

Se realizo un estudio taxonomico de 109 cepas de bacterias heterotrofas aisladas de las aguas del Lago Penuelas, localizado en la V Region, Valparaiso, Chile, junto a 8 cepas de referencia. Se efectuaron 107 pruebas fenotipicas que fueron analizadas por taxonomia numerica. Se encontraron 7 fenones utilizando el coeficiente de apareamiento simple de Sokal y Michener (Ssm) y la lecnica de agrupamiento UPGMA, a un nivel de semejanza del 70%. Los fenones A (9 cepas) y F (3), fueron asignadas al genero Bacillus , 41 cepas fueron incluidas en el genero Flavobacterium (fenones C y E), el fenon B (11), .fue asignado al genero Aeromonas y los fenones D (37) y G (6) fueron incluidos en el genero Acinetobacter .

Published
1993

258. La Experiencia de Peralillo: Una Intervención Psicológica para el Estado de Emergencia

Author

Ana María Fernández, Margarita Loubat, and Mario Morales

Subjects
emergencia, Intervención comunitaria, apoyo emocional, salud mental, desastres naturales
Abstract

El trabajo presenta una intervención en Salud Mental destinada al apoyo emocional de los habitantes de Peralillo y sus alrededores, luego del terremoto que afectó a Chile en Febrero de 2010. Los objetivos fueron realizar actividades de prevención y contención emocional, asentado en las redes intersectoriales de la zona. El diseño de la Intervención contó con 24 voluntarios egresados, practicantes, académicos y profesionales afiliados a la Escuela de Psicología de la Usach, quienes realizaron un total de 14 visitas a la localidad. El alcance de la experiencia fue radial y con efecto dominó. Se realizaron atenciones individuales a 201 personas y 21 talleres de apoyo emocional grupal en espacios comunitarios (alcanzando a 332 personas), además de otras actividades específicas con funcionarios de Salud, prevención y psicoeducación en la Radio local, espacios públicos, salas de espera e intervenciones "puerta a puerta" en 36 hogares. Luego de un cierre de actividades, se evalúa la experiencia como exitosa en la implementación de un trabajo radial en coordinación con las redes de Salud Pública para hacer frente a la emergencia. Sin embargo, también surge la necesidad de abordar la prolongación del desastre en la medida que fuertes réplicas continúan. Se plantea como desafío para la disciplina clínica abordar las necesidades formativas que permitan hacer frente a nuevos desastres naturales, en función de esta experiencia.

259. Regulation of Krüppel-Like Factor 4 (KLF4) expression through the transcription factor Yin-Yang 1 (YY1) in non-Hodgkin B-cell lymphoma

Author

Mario Morales-Martínez, Valencia-Hipolito, A., Vega, G. G., Neri, N., Nambo, M. J., Alvarado, I., Cuadra, I., Duran-Padilla, M. A., Martinez-Maza, O., Huerta-Yepez, S., and Vega, M. I.

Subjects
stomatognathic system, fungi, embryonic structures, sense organs, biological phenomena, cell phenomena, and immunity
Abstract

Krüppel-Like Factor 4 (KLF4) is a member of the KLF transcription factor family, and evidence suggests that KLF4 is either an oncogene or a tumor suppressor. The regulatory mechanism underlying KLF4 expression in cancer, and specifically in lymphoma, is still not understood. Bioinformatics analysis revealed two YY1 putative binding sites in the KLF4 promoter region (-950 bp and -105 bp). Here, the potential regulation of KLF4 by YY1 in NHL was analyzed. Mutation of the putative YY1 binding sites in a previously reported system containing the KLF4 promoter region and CHIP analysis confirmed that these binding sites are important for KLF4 regulation. B-NHL cell lines showed that both KLF4 and YY1 are co-expressed, and transfection with siRNA-YY1 resulted in significant inhibition of KLF4. The clinical implications of YY1 in the transcriptional regulation of KLF4 were investigated by IHC in a TMA with 43 samples of subtypes DLBCL and FL, and all tumor tissues expressing YY1 demonstrated a correlation with KLF4 expression, which was consistent with bioinformatics analyses in several databases. Our findings demonstrated that KLF4 can be transcriptionally regulated by YY1 in B-NHL, and a correlation between YY1 expression and KLF4 was found in clinical samples. Hence, both YY1 and KLF4 may be possible therapeutic biomarkers of NHL.

260. A survey for variable young stars with small telescopes: II - Mapping a protoplanetary disk with stable structures at 0.15 AU

Author

Evitts, Jack J., Froebrich, Dirk, Scholz, Aleks, Eislöffel, Jochen, Campbell-White, Justyn, Furnell, Will, Urtly, Thomas, Pickard, Roger, Wiersema, Klaas, Dubovský, Pavol A., Kudzej, Igor, Naves, Ramon, Aimar, Mario Morales, García, Rafael Castillo, Vanmunster, Tonny, Schwendeman, Erik, Alfaro, Francisco C. Soldán, Johnstone, Stephen, Farfán, Rafael Gonzalez, Killestein, Thomas, Casal, Jesús Delgado, de la Cuesta, Faustino García, Roberts, Dean, Kolb, Ulrich, Montoro, Luís, Licchelli, Domenico, Perez, Alex Escartin, Perez, Carlos Perelló, Deldem, Marc, Futcher, Stephen R. L., Nelson, Tim, Dvorak, Shawn, Moździerski, Dawid, Quinn, Nick, Kotysz, Krzysztof, Kowalska, Katarzyna, Mikołajczyk, Przemysław, Fleming, George, Phillips, Mark, Vale, Tony, Dubois, Franky, Logie, Ludwig, Rau, Steve, Vanaverbeke, Siegfried, Merrikin, Barry, Mañanes, Esteban Fernández, Erdelyi, Emery, Carballo, Juan-Luis Gonzalez, Martinez, Fernando Limon, Long, Timothy P., Segundo Delgado, Adolfo San, Salto González, Josép Luis, Espasa, Luis Tremosa, Piehler, Georg, Crumpton, James, Billington, Samuel J., D’Arcy, Emma, Makin, Sally V., Dover, Lord, Evitts, Jack J., Froebrich, Dirk, Scholz, Aleks, Eislöffel, Jochen, Campbell-White, Justyn, Furnell, Will, Urtly, Thomas, Pickard, Roger, Wiersema, Klaas, Dubovský, Pavol A., Kudzej, Igor, Naves, Ramon, Aimar, Mario Morales, García, Rafael Castillo, Vanmunster, Tonny, Schwendeman, Erik, Alfaro, Francisco C. Soldán, Johnstone, Stephen, Farfán, Rafael Gonzalez, Killestein, Thomas, Casal, Jesús Delgado, de la Cuesta, Faustino García, Roberts, Dean, Kolb, Ulrich, Montoro, Luís, Licchelli, Domenico, Perez, Alex Escartin, Perez, Carlos Perelló, Deldem, Marc, Futcher, Stephen R. L., Nelson, Tim, Dvorak, Shawn, Moździerski, Dawid, Quinn, Nick, Kotysz, Krzysztof, Kowalska, Katarzyna, Mikołajczyk, Przemysław, Fleming, George, Phillips, Mark, Vale, Tony, Dubois, Franky, Logie, Ludwig, Rau, Steve, Vanaverbeke, Siegfried, Merrikin, Barry, Mañanes, Esteban Fernández, Erdelyi, Emery, Carballo, Juan-Luis Gonzalez, Martinez, Fernando Limon, Long, Timothy P., Segundo Delgado, Adolfo San, Salto González, Josép Luis, Espasa, Luis Tremosa, Piehler, Georg, Crumpton, James, Billington, Samuel J., D’Arcy, Emma, Makin, Sally V., and Dover, Lord

Abstract

The HOYS citizen science project conducts long term, multifilter, high cadence monitoring of large YSO samples with a wide variety of professional and amateur telescopes. We present the analysis of the light curve of V1490 Cyg in the Pelican Nebula. We show that colour terms in the diverse photometric data can be calibrated out to achieve a median photometric accuracy of 0.02 mag in broadband filters, allowing detailed investigations into a variety of variability amplitudes over timescales from hours to several years. Using Gaia DR2 we estimate the distance to the Pelican Nebula to be 870 $^{+70}_{-55}$ pc. V1490 Cyg is a quasi-periodic dipper with a period of 31.447 ± 0.011 d. The obscuring dust has homogeneous properties, and grains larger than those typical in the ISM. Larger variability on short timescales is observed in U and Rc −Hα, with U-amplitudes reaching 3 mag on timescales of hours, indicating the source is accreting. The Hα equivalent width and NIR/MIR colours place V1490 Cyg between CTTS/WTTS and transition disk objects. The material responsible for the dipping is located in a warped inner disk, about 0.15 AU from the star. This mass reservoir can be filled and emptied on time scales shorter than the period at a rate of up to 10−10 M⊙/yr, consistent with low levels of accretion in other T Tauri stars. Most likely the warp at this separation from the star is induced by a protoplanet in the inner accretion disk. However, we cannot fully rule out the possibility of an AA Tau-like warp, or occultations by the Hill sphere around a forming planet.

264. Estrategias para mejorar los resultados de aprendizaje de los alumnos con necesidades educativas especiales del CFT Alfa de Constitución

Author

Henríquez Carrasco, Pedro, Mario Morales Navarro, and Facultad de Humanidades y Educación

Subjects
Proyectos de Educación, Calidad Educacional, Planificación Estratégica, Chile, Mejoramiento de la Educación
Abstract

Tesis ( Magíster en Dirección y Liderazgo para la Gestión Educacional ) Uno de los focos críticos de la educación chilena es la inclusión de los alumnos que presentan algún tipo de condición diferente a la normalidad, definida esta como necesidad educativa especial (en adelante NEE), las que requieren de los apoyos necesarios para el logro de los objetivos de aprendizaje y que pueden ser de carácter permanente o temporal, generada por una condición sociocultural distinta a la norma, producto de la desigualdad económica o por la pertenencia a grupos socioculturales minoritarios. El presente Proyecto de Mejoramiento Institucional (en adelante PMI) se propone generar estrategias para mejorar los resultados de aprendizaje de los alumnos con NEE del CFT ALFA de Constitución. Además, el PMI está orientado, tanto a formular indicadores para el logro de los aprendizajes de los estudiantes, como en definir acciones para mejorar las prácticas pedagógicas y planificar los recursos y procedimientos para la atención de aquellos estudiantes que presentan NEE. La concreción de este PMI permitirá la mejora en los resultados de aprendizaje en los alumnos con NEE del CFT ALFA en el mediano plazo.

Published
2016

265. Analysis of the implementation of occupational safety and health standards at manufacturing companies in the city of Valledupar.

Author

Zambrano CMM and Mendoza DJ

Abstract

Introduction: Occupational safety and health is a process that requires the adoption of measures that guarantee the physical, social and mental wellness of a person, under normative parameters that must be met, supervised, and controlled., Objectives: To diagnose occupational safety and health conditions at manufacturing companies in the city of Valledupar, Colombia., Methods: The study focused on the development of a diagnosis on occupational health and safety conditions at manufacturing companies, based on the application of two instruments which focused mainly on identifying socioeconomic conditions of workers and determining the compliance status of the minimum occupational health and safety standards., Results: According to the determined socioeconomic conditions of the workers participating in the study, it was found that, on average, the companies are complying with only 23% of all the requirements established in the resolution 0312 of 2019., Conclusions: Seventy percent of workers affirm that their companies are not taking any action to implement safety and health procedures at work., Competing Interests: Conflict of interest: None

Published
2021
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266. Interactive Versus Video-Based Training of Police to Communicate Syringe Legality to People Who Inject Drugs: The SHIELD Study, Mexico, 2015-2016.

Author

Arredondo J, Beletsky L, Baker P, Abramovitz D, Artamonova I, Clairgue E, Morales M, Mittal ML, Rocha-Jimenez T, Kerr T, Banuelos A, Strathdee SA, and Cepeda J

Subjects
Adult, HIV Infections prevention & control, HIV Infections transmission, Harm Reduction, Hepatitis C prevention & control, Hepatitis C transmission, Humans, Law Enforcement, Mexico, Needle Sharing adverse effects, Needlestick Injuries prevention & control, Occupational Exposure, Role Playing, Substance Abuse, Intravenous complications, Video Recording, Communication, Criminal Law, Inservice Training methods, Police education, Substance Abuse, Intravenous psychology, Syringes
Abstract

Objectives. To assess how instructional techniques affect officers' intent to communicate syringe legality during searches in Tijuana, Mexico, where pervasive syringe confiscation potentiates risk of HIV and HCV among people who inject drugs (PWID) and of occupational needle-stick injury among police. Methods. Using the SHIELD (Safety and Health Integration in the Enforcement of Laws on Drugs) model, Tijuana police underwent training to encourage communication of syringe possession legality to PWID. Trainees received either passive video or interactive role-play exercise on safer search techniques. We used logistic regression to assess the training's impact on self-reported intent to communicate syringe legality by training type and gender. Results. Officers (n = 1749) were mostly men (86%) assigned to patrol (84%). After the training, intent to communicate the law improved markedly: from 20% to 39% (video group) and 20% to 58% (interactive group). Gender and training type significantly predicted intent to communicate syringe legality. Male and female officers' adjusted odds ratios in the interactive group were 5.37 (95% confidence interval [CI] = 4.56, 6.33) and 9.16 (95% CI = 5.88, 14.28), respectively, after the training. Conclusions. To more effectively persuade police to endorse harm reduction and occupational safety practices, police trainings should include interactive elements.

Published
2019
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267. Laparoscopic management of small bowel intussusception in a 16-year-old with Peutz-Jeghers syndrome.

Author

Gonzalez AM and Clapp B

Subjects
Adolescent, Diagnosis, Differential, Humans, Intussusception diagnosis, Male, Peutz-Jeghers Syndrome diagnosis, Intestine, Small, Intussusception etiology, Intussusception surgery, Laparoscopy methods, Peutz-Jeghers Syndrome complications
Abstract

Introduction: Peutz-Jeghers is a rare autosomal dominant disorder characterized by hamartomatous polyps and discoloration of mucosal membranes. The polyps can occur anywhere in the gastrointestinal tract and can grow large enough to cause bowel obstructions., Case Report: A 16-year-old male presented to the emergency department with signs and symptoms of an acute bowel obstruction. He had 2 days of abdominal pain, obstipation, and vomiting. He had a previous history of a colonoscopy with polypectomy at age 4, and hyperpigmentation of his mucous membranes., Results: Computed tomographic (CT) scan revealed an intussusception of the small intestine. An exploratory laparoscopy found an intussusception of the mid jejunum. A laparoscopic-assisted small bowel resection was performed. Pathology showed a 5-cm polyp that acted as a lead point for the intussusception. Colonoscopy and upper endoscopy revealed 5 more polyps in the stomach and colon that were removed., Conclusion: Small bowel obstructions can be managed successfully with minimally invasive approaches. The treatment of obstruction in these patients is to remove the offending hamartomatous polyp(s). The rest of the intestine needs to be examined and those polyps found should be removed. This can be done intraoperatively with laparoscopic-assisted enteroscopy and colonoscopy.

Published
2008

268. [Emergency cerclage:10 years experience at the ABC Hospital].

Author

Alfaro Jaime A, Velásquez Mario M, Cuervo Humberto R, Abad Eduardo IB, and Fernando GL

Subjects
Adult, Cerclage, Cervical statistics & numerical data, Female, Gestational Age, Hospitals statistics & numerical data, Humans, Mexico, Pregnancy, Pregnancy Outcome, Retrospective Studies, Treatment Outcome, Cerclage, Cervical methods, Uterine Cervical Incompetence surgery
Abstract

Objective: To evaluate the success of emergency cerclage procedures and neonatal outcome at the ABC Hospital., Material and Methods: A retrospective analysis between January 1, 1991 and December 31, 2000 was carried out. Gestational age at the time of the procedure was recorded, as well as the average time in gestational weeks after the procedure, maternal complications and neonatal outcome., Results: Seven patients were included with dilatation of the internal cervical of 3 cm o more and membranes protruding to the vagina in all cases. Patients with uterine activity, a cerclage procedure in a previous pregnancy, and corioamnioitis were excluded. The average gestational age for the procedure was 23.3 weeks. The average length of duration of the current pregnancy after the procedure was 5.4 weeks; with 58.3% of live newborns recorded., Conclusions: The emergency cerclage procedure continues to be a heroic attempt to continue the pregnancy. By the results published in the literature, it can be stated that the prolongation of pregnancy is highly variable with neonatal survival rate between 12-73%.

Published
2003

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