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Immunomodulators, whether natural (polysaccharides) or industrial (non-hemolytic detergents) proved active by themselves, in preventive or curative schemes of experimental leprosy and malaria. However, their activity was most often increased, through joint administration with chemotherapeutic agents.

Flubendazole has been given at a daily dosage of 50 mg/kg for 16 months (extremes 10 and 24 months) to 10 patients with hepatic alveolar echinococcosis. Clinical, morphological and immunological evaluations have been performed every 2 months during the treatment, and in 6 patients after discontinuation of the drug for 24 months. Jaundice persisted or occurred in 7 patients; infectious complications were observed in 4 patients; portal hypertension appeared in 5 patients; metastatic spread was suspected in 2 patients. Subjective improvement and weight gain were reported by 6 patients during the first 4 months of treatment. Severe complications occurring during the period of FZ therapy or within 2 months after withdrawal of the drug led to surgery in 6 patients, and death occurred in 3 cases. These observations demonstrate the inefficacy of FZ in this series of 10 patients with alveolar echinococcosis, possibly related to the extremely poor bioavailability of FZ. Higher plasma concentrations obtained with mebendazole and albendazole could explain the better efficacy of these two drugs despite their similar chemical structures and experimental toxicity upon larval cestodes.

Fortunately, this complex procedure is not systematically used for all patients. However, it becomes classical to use this objective method in comparing the surgical procedures for continence restitution.

In this study we have investigated the main factors influencing the growth of thin films of gold on alkali halides. The nucleation and growth of the first nuclei depend on the nature and the temperature of the substrate, on the evaporation rate and on the nature of contaminant gases. The structure of the films is a function of its thickness. The films were studied by electron diffraction and electron microscopy. Whatever the experimental conditions the films have crystallites with a (001) or (111) plane parallel to the substrate. The intervals of temperature in which the different orientations are found depend on the contaminants and on the nature of the substrate. Successive twins on (111) occur in the first stage of growth. Often these twins occur only on some faces of the cristallites depending on the orientation of the original cristallites., Nous avons étudié l'influence des différents facteurs intervenant dans la nucléation et la croissance des films minces d'or déposés par évaporation thermique sur des charges d'halogénures alcalins : nature et température du support, vitesse d'évaporation et nature des gaz contaminants. La structure des couches est ensuite fonction de leur épaisseur. Elles sont étudiées par diffraction et microscopie électroniques. Quelles que soient les conditions expérimentales, la nucléation conduit à des cristallites avec des plans (001) ou (111) parallèles au plan du support. Les intervalles de température dans lesquels existent les différentes orientations dépendent de la nature du support et des gaz contaminants. Dès les premiers stades de croissance apparaissent des macles multiples qui se développent souvent préférentiellement sur certaines faces des cristallites en relation avec la position des germes initiaux par rapport au support., Gillet E., Roux J.-F., Gillet M. Étude par diffraction électronique de la structure des couches épitaxiques sur les halogénures alcalins. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 90, 1, 1967. pp. 54-65.

L'observation au microscope électronique des cristaux lamellaires montre un très grand nombre de dislocations ; leur étude directe, souvent difficile, est facilitée par l'observation des moirés. Notre étude met en évidence, par ce procédé, des dislocations parfaites ou partielles sur des cristaux lamellaires d'or et de molybdénite., Gillet M. Étude des défauts cristallins par les moirés sur des cristaux d'or et de molybdénite. In: Bulletin de la Société française de Minéralogie et de Cristallographie, volume 83, 10-12, 1960. pp. 245-249.