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Area, perimeter, maximum diameter and form factors of nuclei of FNABs of thyroid nodules were measured with a MOP Videoplan. 23 cases were selected from patients with a scintigraphically cold single thyroid nodule. The mean values of area, perimeter and maximum diameter were significantly different (p less than 0.001) between the adenoma and carcinoma cases; no differences were found for the form factors. Although the analyses gave significant results, a certain amount of overlap of the benign and malignant populations was present; therefore the significance of the standard deviation, assumed to be an index of variability of the nuclear area, was evaluated and this parameter was found to discriminate the two populations. The standard deviation of the nuclear area measured in 14 cases diagnosed as suspicious gave 77% accuracy in discriminating benign from malignant cases.

The Authors describe the case of a multisystem disease affecting a young asthmatic patient. The history and the course of the disease suggested the diagnosis of a primary systemic vasculitis, which had a pathologic picture (both bioptic and autoptic) typical of an allergic angiitis and granulomatosis, also known as Churg-Strauss syndrome.

Sex reassignment surgery is perhaps the most controversial issue in psychiatry today. Clinicians involved in the treatment of transsexualism have been accused of "playing God" or colluding with the patient's psychopathology. This paper reviews the literature and argues for a systematic approach to the treatment of transsexualism.

Three groups of male transsexuals at different stages of the treatment process were examined and shown to match retrospectively in actuarial and psychiatric data. Transsexuals who were on a waiting list for surgery showed lower neurotic scores on the Crown-Crisp Experiential Index than those at the assessment stage of clinic attendance, while post-operative transsexuals obtained scores lower than either of the other groups. Transsexuals during the assessment stage of treatment obtained the lowest scores on items in the Bem Sex Role Inventory that define stereotypical masculine characteristics and the highest scores on items that define stereotypical feminine characteristics, in relation to the other two groups.