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4,224 results on '"Lehtimäki, Terho"'

302. Multi-Ancestry Genome-wide Association Study Accounting for Gene-Psychosocial Factor Interactions Identifies Novel Loci for Blood Pressure Traits

Author

Sun, Daokun, Richard, Melissa, Musani, Solomon, Sung, Yun Ju, Winkler, Thomas, Schwander, Karen, Chai, Jin Fang, Guo, Xiuqing, Kilpeläinen, Tuomas, Vojinovic, Dina, Aschard, Hugues, Bartz, Traci, Bielak, Lawrence, Brown, Michael, Chitrala, Kumaraswamy, Hartwig, Fernando, Horimoto, Andrea R.V.R., Liu, Yongmei, Manning, Alisa, Noordam, Raymond, Smith, Albert, Harris, Sarah, Kühnel, Brigitte, Lyytikäinen, Leo-Pekka, Nolte, Ilja, Rauramaa, Rainer, van Der Most, Peter, Wang, Rujia, Ware, Erin, Weiss, Stefan, Wen, Wanqing, Yanek, Lisa, Arking, Dan, Arnett, Donna, Barac, Ana, Boerwinkle, Eric, Broeckel, Ulrich, Chakravarti, Aravinda, Chen, Yii-Der Ida, Cupples, L. Adrienne, Davigulus, Martha, de Las Fuentes, Lisa, de Mutsert, Renée, de Vries, Paul, Delaney, Joseph A.C., Diez Roux, Ana, Dörr, Marcus, Faul, Jessica, Fretts, Amanda, Gallo, Linda, Grabe, Hans Jörgen, Gu, C. Charles, Harris, Tamara, Hartman, Catharina C.A., Heikkinen, Sami, Ikram, M. Arfan, Isasi, Carmen, Johnson, W. Craig, Jonas, Jost Bruno, Kaplan, Robert, Komulainen, Pirjo, Krieger, Jose, Levy, Daniel, Liu, Jianjun, Lohman, Kurt, Luik, Annemarie, Martin, Lisa, Meitinger, Thomas, Milaneschi, Yuri, O’connell, Jeff, Palmas, Walter, Peters, Annette, Peyser, Patricia, Pulkki-Råback, Laura, Raffel, Leslie, Reiner, Alex, Rice, Kenneth, Robinson, Jennifer, Rosendaal, Frits, Schmidt, Carsten Oliver, Schreiner, Pamela, Schwettmann, Lars, Shikany, James, Shu, Xiao-Ou, Sidney, Stephen, Sims, Mario, Smith, Jennifer, Sotoodehnia, Nona, Strauch, Konstantin, Tai, E. Shyong, Taylor, Kent, Uitterlinden, André, van Duijn, Cornelia, Waldenberger, Melanie, Wee, Hwee-Lin, Wei, Wen-Bin, Wilson, Gregory, Xuan, Deng, Yao, Jie, Zeng, Donglin, Zhao, Wei, Zhu, Xiaofeng, Zonderman, Alan, Becker, Diane, Deary, Ian, Gieger, Christian, Lakka, Timo, Lehtimäki, Terho, North, Kari, Oldehinkel, Albertine, Penninx, Brenda W.J.H., Snieder, Harold, Wang, Ya-Xing, Weir, David, Zheng, Wei, Evans, Michele, Gauderman, W. James, Gudnason, Vilmundur, Horta, Bernardo, Liu, Ching-Ti, Mook-Kanamori, Dennis, Morrison, Alanna, Pereira, Alexandre, Psaty, Bruce, Amin, Najaf, Fox, Ervin, Kooperberg, Charles, Sim, Xueling, Bierut, Laura, Rotter, Jerome, Kardia, Sharon L.R., Franceschini, Nora, Rao, Dabeeru, Fornage, Myriam, Horimoto, Andrea, Cupples, L Adrienne, Delaney, Joseph, Roux, Ana, Gu, C Charles, Hartman, Catharina, Ikram, M Arfan, Johnson, W Craig, O'Connell, Jeff, Tai, E Shyong, Penninx, Brenda, Gauderman, W James, Kardia, Sharon, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, APH - Mental Health, APH - Digital Health, HUS Abdominal Center, Faculty of Medicine, University of Helsinki, Department of Psychology and Logopedics, Psychosocial factors and health, University of Texas Health Science Center, The University of Texas Health Science Center at Houston (UTHealth), University of Mississippi Medical Center (UMMC), Washington University School of Medicine in St. Louis, Washington University in Saint Louis (WUSTL), University of Regensburg, National University of Singapore (NUS), Harbor UCLA Medical Center [Torrance, Ca.], IT University of Copenhagen (ITU), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Harvard School of Public Health, Département de Génomes et Génétique - Department of Genomes and Genetics, Institut Pasteur [Paris] (IP), University of Washington [Seattle], University of Michigan [Ann Arbor], University of Michigan System, National Institute on Aging [Bethesda, USA] (NIA), National Institutes of Health [Bethesda] (NIH), Universidade Federal de Pelotas = Federal University of Pelotas (UFPel), Universidade de São Paulo = University of São Paulo (USP), Wake Forest University, Broad Institute of MIT and Harvard (BROAD INSTITUTE), Harvard Medical School [Boston] (HMS)-Massachusetts Institute of Technology (MIT)-Massachusetts General Hospital [Boston], Leiden University Medical Center (LUMC), Universiteit Leiden, University of Edinburgh, This project was largely supported by grant R01HL118305 from the US National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health, with additional support from R01HL105756. A full set of study-specific funding sources and acknowledgments is provided in the Supplemental subjects and methods., We thank all study participants for contributing to this work., Tampere University, Clinical Medicine, Department of Clinical Chemistry, Epidemiology, Radiology & Nuclear Medicine, Child and Adolescent Psychiatry / Psychology, Internal Medicine, Life Course Epidemiology (LCE), and Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)

Subjects
Mean arterial pressure, hypertension, Genome-wide association study, QH426-470, Biology, Article, GxE, 03 medical and health sciences, Social support, 0302 clinical medicine, depressive symptoms, SDG 3 - Good Health and Well-being, Genetics, medicine, GWAS, Gene–environment interaction, psychosocial factors, gene-environment interaction, genome-wide association study, blood pressure, hypertension, psychosocial factors,depressive symptoms, GWAS, GxE, Genetics (clinical), 030304 developmental biology, [STAT.AP]Statistics [stat]/Applications [stat.AP], 0303 health sciences, genome-wide association study, blood pressure, 3. Good health, Pulse pressure, gene-environment interaction, Blood pressure, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Molecular Medicine, Anxiety, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 3111 Biomedicine, [INFO.INFO-BI]Computer Science [cs]/Bioinformatics [q-bio.QM], medicine.symptom, [STAT.ME]Statistics [stat]/Methodology [stat.ME], Psychosocial, 030217 neurology & neurosurgery
Abstract

Publisher Copyright: © 2020 The Author(s) Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A and PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5 and CHODL). These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations.

Published
2021

303. Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory

Author

van den Berg, Stéphanie M., de Moor, Marleen H. M., McGue, Matt, Pettersson, Erik, Terracciano, Antonio, Verweij, Karin J. H., Amin, Najaf, Derringer, Jaime, Esko, Tõnu, van Grootheest, Gerard, Hansell, Narelle K., Huffman, Jennifer, Konte, Bettina, Lahti, Jari, Luciano, Michelle, Matteson, Lindsay K., Viktorin, Alexander, Wouda, Jasper, Agrawal, Arpana, Allik, Jüri, Bierut, Laura, Broms, Ulla, Campbell, Harry, Smith, George Davey, Eriksson, Johan G., Ferrucci, Luigi, Franke, Barbera, Fox, Jean-Paul, de Geus, Eco J. C., Giegling, Ina, Gow, Alan J., Grucza, Richard, Hartmann, Annette M., Heath, Andrew C., Heikkilä, Kauko, Iacono, William G., Janzing, Joost, Jokela, Markus, Kiemeney, Lambertus, Lehtimäki, Terho, Madden, Pamela A. F., Magnusson, Patrik K. E., Northstone, Kate, Nutile, Teresa, Ouwens, Klaasjan G., Palotie, Aarno, Pattie, Alison, Pesonen, Anu-Katriina, Polasek, Ozren, Pulkkinen, Lea, Pulkki-Råback, Laura, Raitakari, Olli T., Realo, Anu, Rose, Richard J., Ruggiero, Daniela, Seppälä, Ilkka, Slutske, Wendy S., Smyth, David C., Sorice, Rossella, Starr, John M., Sutin, Angelina R., Tanaka, Toshiko, Verhagen, Josine, Vermeulen, Sita, Vuoksimaa, Eero, Widen, Elisabeth, Willemsen, Gonneke, Wright, Margaret J., Zgaga, Lina, Rujescu, Dan, Metspalu, Andres, Wilson, James F., Ciullo, Marina, Hayward, Caroline, Rudan, Igor, Deary, Ian J., Räikkönen, Katri, Arias Vasquez, Alejandro, Costa, Paul T., Keltikangas-Järvinen, Liisa, van Duijn, Cornelia M., Penninx, Brenda W. J. H., Krueger, Robert F., Evans, David M., Kaprio, Jaakko, Pedersen, Nancy L., Martin, Nicholas G., and Boomsma, Dorret I.

Published
2014
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307. Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index

Author

Felix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J.P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Møller, Eskil, Mahajan, Anubha, Pitkänen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimäki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loïc, Grarup, Niels, Ntalla, Ioanna, Ang, Wei, Atalay, Mustafa, Bisgaard, Hans, Blakemore, Alexandra I., Bonnefond, Amelie, Carstensen, Lisbeth, Eriksson, Johan, Flexeder, Claudia, Franke, Lude, Geller, Frank, Geserick, Mandy, Hartikainen, Anna-Liisa, Haworth, Claire M.A., Hirschhorn, Joel N., Hofman, Albert, Holm, Jens-Christian, Horikoshi, Momoko, Hottenga, Jouke Jan, Huang, Jinyan, Kadarmideen, Haja N., Kähönen, Mika, Kiess, Wieland, Lakka, Hanna-Maaria, Lakka, Timo A., Lewin, Alexandra M., Liang, Liming, Lyytikäinen, Leo-Pekka, Ma, Baoshan, Magnus, Per, McCormack, Shana E., McMahon, George, Mentch, Frank D., Middeldorp, Christel M., Murray, Clare S., Pahkala, Katja, Pers, Tune H., Pfäffle, Roland, Postma, Dirkje S., Power, Christine, Simpson, Angela, Sengpiel, Verena, Tiesler, Carla M. T., Torrent, Maties, Uitterlinden, André G., van Meurs, Joyce B., Vinding, Rebecca, Waage, Johannes, Wardle, Jane, Zeggini, Eleftheria, Zemel, Babette S., Dedoussis, George V., Pedersen, Oluf, Froguel, Philippe, Sunyer, Jordi, Plomin, Robert, Jacobsson, Bo, Hansen, Torben, Gonzalez, Juan R., Custovic, Adnan, Raitakari, Olli T., Pennell, Craig E., Widén, Elisabeth, Boomsma, Dorret I., Koppelman, Gerard H., Sebert, Sylvain, Järvelin, Marjo-Riitta, Hyppönen, Elina, McCarthy, Mark I., Lindi, Virpi, Harri, Niinikoski, Körner, Antje, Bønnelykke, Klaus, Heinrich, Joachim, Melbye, Mads, Rivadeneira, Fernando, Hakonarson, Hakon, Ring, Susan M., Smith, George Davey, Sørensen, Thorkild I.A., Timpson, Nicholas J., Grant, Struan F.A., Jaddoe, Vincent W.V., Kalkwarf, Heidi J., Lappe, Joan M., Gilsanz, Vicente, Oberfield, Sharon E., Shepherd, John A., Kelly, Andrea, and Zemel, Babette S.

Published
2016
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308. Uncovering the complex genetic architecture of human plasma lipidome using machine learning methods.

Author

Lehtimäki, Miikael, H. Mishra, Binisha, Del-Val, Coral, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Cloninger, C. Robert, Raitakari, Olli T., Laaksonen, Reijo, Zwir, Igor, Lehtimäki, Terho, and Mishra, Pashupati P.

Subjects
MACHINE learning, GENETIC variation, METABOLIC regulation, BLOOD lipids, LIPID metabolism
Abstract

Genetic architecture of plasma lipidome provides insights into regulation of lipid metabolism and related diseases. We applied an unsupervised machine learning method, PGMRA, to discover phenotype-genotype many-to-many relations between genotype and plasma lipidome (phenotype) in order to identify the genetic architecture of plasma lipidome profiled from 1,426 Finnish individuals aged 30–45 years. PGMRA involves biclustering genotype and lipidome data independently followed by their inter-domain integration based on hypergeometric tests of the number of shared individuals. Pathway enrichment analysis was performed on the SNP sets to identify their associated biological processes. We identified 93 statistically significant (hypergeometric p-value < 0.01) lipidome-genotype relations. Genotype biclusters in these 93 relations contained 5977 SNPs across 3164 genes. Twenty nine of the 93 relations contained genotype biclusters with more than 50% unique SNPs and participants, thus representing most distinct subgroups. We identified 30 significantly enriched biological processes among the SNPs involved in 21 of these 29 most distinct genotype-lipidome subgroups through which the identified genetic variants can influence and regulate plasma lipid related metabolism and profiles. This study identified 29 distinct genotype-lipidome subgroups in the studied Finnish population that may have distinct disease trajectories and therefore could be useful in precision medicine research. [ABSTRACT FROM AUTHOR]

Published
2023
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309. Inflammatory Diseases, Inflammatory Biomarkers, and Alzheimer Disease: An Observational Analysis and Mendelian Randomization.

Author

Huang, Jian, Su, Bowen, Karhunen, Ville, Gill, Dipender, Zuber, Verena, Ahola-Olli, Ari, Palaniswamy, Saranya, Auvinen, Juha, Herzig, Karl-Heinz, Keinänen-Kiukaanniemi, Sirkka, Salmi, Marko, Jalkanen, Sirpa, Lehtimäki, Terho, Salomaa, Veikko, Raitakari, Olli T., Matthews, Paul M., Elliott, Paul, Tsilidis, Konstantinos K., Jarvelin, Marjo-riitta, and Tzoulaki, Ioanna

Published
2023
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310. A new blood based epigenetic age predictor for adolescents and young adults.

Author

Aanes, Håvard, Bleka, Øyvind, Dahlberg, Pål Skage, Carm, Kristina Totland, Lehtimäki, Terho, Raitakari, Olli, Kähönen, Mika, Hurme, Mikko, and Rolseth, Veslemøy

Subjects
YOUNG adults, AGE, TEENAGERS, EPIGENETICS, DNA methylation, HUMAN genome, METHYLATION
Abstract

Children have special rights for protection compared to adults in our society. However, more than 1/4 of children globally have no documentation of their date of birth. Hence, there is a pressing need to develop biological methods for chronological age prediction, robust to differences in genetics, psychosocial events and physical living conditions. At present, DNA methylation is the most promising biological biomarker applied for age assessment. The human genome contains around 28 million DNA methylation sites, many of which change with age. Several epigenetic clocks accurately predict chronological age using methylation levels at age associated GpG-sites. However, variation in DNA methylation increases with age, and there is no epigenetic clock specifically designed for adolescents and young adults. Here we present a novel age Predictor for Adolescents and Young Adults (PAYA), using 267 CpG methylation sites to assess the chronological age of adolescents and young adults. We compared different preprocessing approaches and investigated the effect on prediction performance of the epigenetic clock. We evaluated performance using an independent validation data set consisting of 18-year-old individuals, where we obtained a median absolute deviation of just below 0.7 years. This tool may be helpful in age assessment of adolescents and young adults. However, there is a need to investigate the robustness of the age predictor across geographical and disease populations as well as environmental effects. [ABSTRACT FROM AUTHOR]

Published
2023
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311. Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.

Author

Elhakeem, Ahmed, Ronkainen, Justiina, Mansell, Toby, Lange, Katherine, Mikkola, Tuija M., Mishra, Binisha H., Wahab, Rama J., Cadman, Tim, Yang, Tiffany, Burgner, David, Eriksson, Johan G., Järvelin, Marjo-Riitta, Gaillard, Romy, Jaddoe, Vincent W. V., Lehtimäki, Terho, Raitakari, Olli T., Saffery, Richard, Wake, Melissa, Wright, John, and Sebert, Sylvain

Subjects
PREGNANCY complications, WATER-electrolyte balance (Physiology), GESTATIONAL diabetes, GESTATIONAL age, PREMATURE labor, ASPHYXIA neonatorum, DYSLIPIDEMIA
Abstract

Background: Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations might differ with offspring age. Methods: We used data from eight population-based cohort studies to examine and compare associations of pre-eclampsia (PE), gestational hypertension (GH), gestational diabetes (GD), preterm birth (PTB), small (SGA) and large (LGA) for gestational age (vs. appropriate size for gestational age (AGA)) with up to 167 plasma/serum-based nuclear magnetic resonance-derived metabolic traits encompassing lipids, lipoproteins, fatty acids, amino acids, ketones, glycerides/phospholipids, glycolysis, fluid balance, and inflammation. Confounder-adjusted regression models were used to examine associations (adjusted for maternal education, parity age at pregnancy, ethnicity, pre/early pregnancy body mass index and smoking, and offspring sex and age at metabolic trait assessment), and results were combined using meta-analysis by five age categories representing different periods of the offspring life course: neonates (cord blood), infancy (mean ages: 1.1–1.6 years), childhood (4.2–7.5 years); adolescence (12.0–16.0 years), and adulthood (22.0–67.8 years). Results: Offspring numbers for each age category/analysis varied from 8925 adults (441 PTB) to 1181 infants (135 GD); 48.4% to 60.0% were females. Pregnancy complications (PE, GH, GD) were each associated with up to three metabolic traits in neonates (P≤0.001) with some evidence of persistence to older ages. PTB and SGA were associated with 32 and 12 metabolic traits in neonates respectively, which included an adjusted standardised mean difference of −0.89 standard deviation (SD) units for albumin with PTB (95% CI: −1.10 to −0.69, P=1.3×10−17) and −0.41 SD for total lipids in medium HDL with SGA (95% CI: −0.56 to −0.25, P=2.6×10−7), with some evidence of persistence to older ages. LGA was inversely associated with 19 metabolic traits including lower levels of cholesterol, lipoproteins, fatty acids, and amino acids, with associations emerging in adolescence, (e.g. −0.11 SD total fatty acids, 95% CI: −0.18 to −0.05, P=0.0009), and attenuating with older age across adulthood. Conclusions: These reassuring findings suggest little evidence of wide-spread and long-term impact of common pregnancy and perinatal complications on offspring metabolic traits, with most associations only observed for newborns rather than older ages, and for perinatal rather than pregnancy complications. [ABSTRACT FROM AUTHOR]

Published
2023
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314. Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs

Author

Marttila, Saara, Viiri, Leena E., Mishra, Pashupati P., Kühnel, Brigitte, Matias-Garcia, Pamela R., Lyytikäinen, Leo-Pekka, Ceder, Tiina, Mononen, Nina, Rathmann, Wolfgang, Winkelmann, Juliane, Peters, Annette, Kähönen, Mika, Hutri-Kähönen, Nina, Juonala, Markus, Aalto-Setälä, Katriina, Raitakari, Olli, Lehtimäki, Terho, Waldenberger, Melanie, Raitoharju, Emma, Tampere University, Department of Clinical Chemistry, Clinical Medicine, BioMediTech, Department of Clinical Physiology and Nuclear Medicine, and TAYS Heart Centre

Subjects
Adult, nc886, RNA, Untranslated, Genomic imprinting, Research, Population studies, Humans, miR-886, 3111 Biomedicine, DNA Methylation, vtRNA2-1, Epigenesis, Genetic, Glucose Metabolism Disorders
Abstract

Background Non-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the methylation pattern at the nc886 epiallele and how this methylation status associates with nc886 RNA expression. Furthermore, we investigated the associations between the nc886 methylation status or the levels of nc886 RNAs and metabolic traits in the YFS and KORA cohorts. The association between nc886 epiallele methylation and RNA expression was also validated in induced pluripotent stem cell (iPSC) lines. Results We confirm that the methylation status of the nc886 epiallele is mostly binomial, with individuals displaying either a non- or hemi-methylated status, but we also describe intermediately and close to fully methylated individuals. We show that an individual’s methylation status is associated with the mother’s age and socioeconomic status, but not with the individual’s own genetics. Once established, the methylation status of the nc886 epiallele remains stable for at least 25 years. This methylation status is strongly associated with the levels of nc886 non-coding RNAs in serum, blood, and iPSC lines. In addition, nc886 methylation status associates with glucose and insulin levels during adolescence but not with the indicators of glucose metabolism or the incidence of type 2 diabetes in adulthood. However, the nc886-3p RNA levels also associate with glucose metabolism in adulthood. Conclusions These results indicate that nc886 metastable epiallele methylation is tuned by the periconceptional conditions and it associates with glucose metabolism through the expression of the ncRNAs coded in the epiallele region. Supplementary Information The online version contains supplementary material available at 10.1186/s13148-021-01132-3.

Published
2021

315. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging

Author

McCartney, Daniel L, Min, Josine L, Richmond, Rebecca C, Lu, Ake T, Sobczyk, Maria K, Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R, Mishra, Pashupati P, Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M, Ratliff, Scott M, Richardson, Tom G, Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D, Walker, Rosie M, Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R, Gieger, Christian, Genetics of DNA Methylation Consortium, de Geus, Eco JC, Harris, Sarah E, Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon LR, Kresovich, Jacob K, Li, Shengxu, Lunetta, Kathryn L, Mangino, Massimo, Mason, Dan, McIntosh, Andrew M, Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ollikainen, Miina, Pankow, James S, Pedersen, Nancy L, Peters, Annette, Polidoro, Silvia, Porteous, David J, Raitakari, Olli, Rich, Stephen S, Sandler, Dale P, Sillanpää, Elina, Smith, Alicia K, Southey, Melissa C, Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G, Van Den Berg, David J, van Dongen, Jenny, Wilson, James G, Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T, Binder, Alexandra M, Boomsma, Dorret I, Chen, Wei, Christensen, Kaare, Conneely, Karen N, Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A, Lehtimäki, Terho, Lohoff, Falk W, Milani, Lili, Milne, Roger L, Probst-Hensch, Nicole, and Reiner, Alex P

Subjects
Genetic Markers, Aging, Multifactorial Inheritance, Epigenetic clock, Bioinformatics, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Genetic, Information and Computing Sciences, Plasminogen Activator Inhibitor 1, Genetics, Humans, Innate, GWAS, Adiposity, Nutrition, Genome, DNA methylation, Prevention, Inflammatory and immune system, Human Genome, Immunity, Genetics of DNA Methylation Consortium, Biological Sciences, Lipid Metabolism, C-Reactive Protein, Good Health and Well Being, Genetic Loci, Educational Status, CpG Islands, Generic health relevance, Biomarkers, Environmental Sciences, Granulocytes, Epigenesis, Human, Genome-Wide Association Study
Abstract

BackgroundBiological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field.ResultsLeveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci associated with the Horvath clock and expression of transcripts encoding genes linked to lipid metabolism and immune function. Notably, these loci are independent of those reported to regulate DNA methylation levels at constituent clock CpGs. A polygenic score for GrimAge acceleration showed strong associations with adiposity-related traits, educational attainment, parental longevity, and C-reactive protein levels.ConclusionThis study illuminates the genetic architecture underlying epigenetic aging and its shared genetic contributions with lifestyle factors and longevity.

Published
2021

316. Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Author

Estonian Biobank Research Team, BioBank Japan Project, FinnGen, Ruotsalainen, Sanni E., Surakka, Ida, Mars, Nina, Karjalainen, Juha, Kurki, Mitja, Kanai, Masahiro, Krebs, Kristi, Graham, Sarah, Mishra, Pashupati P., Mishra, Binisha H., Sinisalo, Juha, Palta, Priit, Lehtimäki, Terho, Raitakari, Olli, Milani, Lili, Okada, Yukinori, Palotie, Aarno, Widen, Elisabeth, Daly, Mark J., Ripatti, Samuli, Tienari, Pentti, University of Helsinki, Institute for Molecular Medicine Finland, Samuli Olli Ripatti / Principal Investigator, Complex Disease Genetics, Faculty Common Matters (Faculty of Medicine), Institute of Biotechnology, Department of Clinical Chemistry and Hematology, HUS Heart and Lung Center, Helsinki University Hospital Area, Clinicum, Department of Medicine, Genomics of Neurological and Neuropsychiatric Disorders, Centre of Excellence in Complex Disease Genetics, Research Programs Unit, Aarno Palotie / Principal Investigator, Helsinki Institute of Life Science HiLIFE, Elisabeth Ingrid Maria Widen / Principal Investigator, Genomic Discoveries and Clinical Translation, Doctoral Programme in Social Sciences, Department of Public Health, HUS Neurocenter, Department of Neurosciences, Neurologian yksikkö, Tampere University, Clinical Medicine, and Department of Clinical Chemistry

Subjects
HUMAN-MILK, EXPRESSION, IDENTIFICATION, CARDIOVASCULAR RISK, Medicine (miscellaneous), Coronary Artery Disease, Milk Proteins, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, ANGIOTENSIN-II, Mice, Cardiovascular Diseases, Genetic Loci, 3121 General medicine, internal medicine and other clinical medicine, Antigens, Surface, COHORT PROFILE, APOPTOTIC CELLS, GROWTH, Animals, Humans, 3111 Biomedicine, LIQUID-CHROMATOGRAPHY, MEMBRANE, General Agricultural and Biological Sciences, Genome-Wide Association Study
Abstract

Publisher Copyright: © 2022. The Author(s). A genome-wide association study identifies MFGE8 as protective against coronary atherosclerosis in European and East Asian populations. Cardiovascular diseases are the leading cause of premature death and disability worldwide, with both genetic and environmental determinants. While genome-wide association studies have identified multiple genetic loci associated with cardiovascular diseases, exact genes driving these associations remain mostly uncovered. Due to Finland's population history, many deleterious and high-impact variants are enriched in the Finnish population giving a possibility to find genetic associations for protein-truncating variants that likely tie the association to a gene and that would not be detected elsewhere. In a large Finnish biobank study FinnGen, we identified an association between an inframe insertion rs534125149 in MFGE8 (encoding lactadherin) and protection against coronary atherosclerosis. This variant is highly enriched in Finland, and the protective association was replicated in meta-analysis of BioBank Japan and Estonian biobank. Additionally, we identified a protective association between splice acceptor variant rs201988637 in MFGE8 and coronary atherosclerosis, independent of the rs534125149, with no significant risk-increasing associations. This variant was also associated with lower pulse pressure, pointing towards a function of MFGE8 in arterial aging also in humans in addition to previous evidence in mice. In conclusion, our results suggest that inhibiting the production of lactadherin could lower the risk for coronary heart disease substantially.

Published
2021

317. Mitochondrial genome-wide analysis of nuclear DNA methylation quantitative trait loci

Author

Laaksonen, Jaakko, primary, Mishra, Pashupati P, additional, Seppälä, Ilkka, additional, Raitoharju, Emma, additional, Marttila, Saara, additional, Mononen, Nina, additional, Lyytikäinen, Leo-Pekka, additional, Kleber, Marcus E, additional, Delgado, Graciela E, additional, Lepistö, Maija, additional, Almusa, Henrikki, additional, Ellonen, Pekka, additional, Lorkowski, Stefan, additional, März, Winfried, additional, Hutri-Kähönen, Nina, additional, Raitakari, Olli, additional, Kähönen, Mika, additional, Salonen, Jukka T, additional, and Lehtimäki, Terho, additional

Published
2021
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318. Genetic analyses of the QT interval and its components in over 250K individuals identifies new loci and pathways affecting ventricular depolarization and repolarization

Author

Young, William J., primary, Lahrouchi, Najim, additional, Isaacs, Aaron, additional, Duong, ThuyVy, additional, Foco, Luisa, additional, Ahmed, Farah, additional, Brody, Jennifer A., additional, Salman, Reem, additional, Noordam, Raymond, additional, Benjamins, Jan-Walter, additional, Haessler, Jeffrey, additional, Lyytikäinen, Leo-Pekka, additional, Repetto, Linda, additional, Concas, Maria Pina, additional, van den Berg, Marten E., additional, Weiss, Stefan, additional, Baldassari, Antoine R., additional, Bartz, Traci M., additional, Cook, James P., additional, Evans, Daniel S., additional, Freudling, Rebecca, additional, Hines, Oliver, additional, Isaksen, Jonas L., additional, Lin, Honghuang, additional, Mei, Hao, additional, Moscati, Arden, additional, Müller-Nurasyid, Martina, additional, Nursyifa, Casia, additional, Qian, Yong, additional, Richmond, Anne, additional, Roselli, Carolina, additional, Ryan, Kathleen A., additional, Tarazona-Santos, Eduardo, additional, Thériault, Sébastien, additional, van Duijvenboden, Stefan, additional, Warren, Helen R., additional, Yao, Jie, additional, Raza, Dania, additional, Aeschbacher, Stefanie, additional, Ahlberg, Gustav, additional, Alonso, Alvaro, additional, Andreasen, Laura, additional, Bis, Joshua C., additional, Boerwinkle, Eric, additional, Campbell, Archie, additional, Catamo, Eulalia, additional, Cocca, Massimiliano, additional, Cutler, Michael J., additional, Darbar, Dawood, additional, De Grandi, Alessandro, additional, De Luca, Antonio, additional, Ding, Jun, additional, Ellervik, Christina, additional, Ellinor, Patrick T., additional, Felix, Stephan B., additional, Froguel, Philippe, additional, Fuchsberger, Christian, additional, Gögele, Martin, additional, Graff, Claus, additional, Graff, Mariaelisa, additional, Guo, Xiuqing, additional, Hansen, Torben, additional, Heckbert, Susan R., additional, Huang, Paul L., additional, Huikuri, Heikki V., additional, Hutri-Kähönen, Nina, additional, Ikram, M.Arfan, additional, Jackson, Rebecca D., additional, Junttila, Juhani, additional, Kavousi, Maryam, additional, Kors, Jan A., additional, Leal, Thiago P., additional, Lemaitre, Rozenn N., additional, Lin, Henry J., additional, Lind, Lars, additional, Linneberg, Allan, additional, Liu, Simin, additional, MacFarlane, Peter W., additional, Mangino, Massimo, additional, Meitinger, Thomas, additional, Mezzavilla, Massimo, additional, Mishra, Pashupati P., additional, Mitchell, Rebecca N., additional, Mononen, Nina, additional, Montasser, May E., additional, Morrison, Alanna C., additional, Nauck, Matthias, additional, Nauffal, Victor, additional, Navarro, Pau, additional, Nikus, Kjell, additional, Pare, Guillaume, additional, Patton, Kristen K., additional, Pelliccione, Giulia, additional, Pittman, Alan, additional, Porteous, David J., additional, Pramstaller, Peter P., additional, Preuss, Michael H., additional, Raitakari, Olli T., additional, Reiner, Alexander P., additional, Ribeiro, Antonio Luiz P., additional, Rice, Kenneth M., additional, Risch, Lorenz, additional, Schlessinger, David, additional, Schotten, Ulrich, additional, Schurmann, Claudia, additional, Shen, Xia, additional, Shoemaker, M.Benjamin, additional, Sinagra, Gianfranco, additional, Sinner, Moritz F., additional, Soliman, Elsayed Z., additional, Stoll, Monika, additional, Strauch, Konstantin, additional, Tarasov, Kirill, additional, Taylor, Kent D., additional, Tinker, Andrew, additional, Trompet, Stella, additional, Uitterlinden, André, additional, Völker, Uwe, additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Weng, Lu-Chen, additional, Whitsel, Eric A., additional, Wilson, James G., additional, Avery, Christy L., additional, Conen, David, additional, Correa, Adolfo, additional, Cucca, Francesco, additional, Dörr, Marcus, additional, Gharib, Sina A., additional, Girotto, Giorgia, additional, Grarup, Niels, additional, Hayward, Caroline, additional, Jamshidi, Yalda, additional, Järvelin, Marjo-Riitta, additional, Jukema, J.Wouter, additional, Kääb, Stefan, additional, Kähönen, Mika, additional, Kanters, Jørgen K., additional, Kooperberg, Charles, additional, Lehtimäki, Terho, additional, Lima-Costa, Maria Fernanda, additional, Liu, Yongmei, additional, Loos, Ruth J.F., additional, Lubitz, Steven A., additional, Mook-Kanamori, Dennis O., additional, Morris, Andrew P., additional, O’Connell, Jeffrey R., additional, Olesen, Morten Salling, additional, Orini, Michele, additional, Padmanabhan, Sandosh, additional, Pattaro, Cristian, additional, Peters, Annette, additional, Psaty, Bruce M., additional, Rotter, Jerome I., additional, Stricker, Bruno, additional, van der Harst, Pim, additional, van Duijn, Cornelia M., additional, Verweij, Niek, additional, Wilson, James F., additional, Arking, Dan E., additional, Ramirez, Julia, additional, Lambiase, Pier D., additional, Sotoodehnia, Nona, additional, Mifsud, Borbala, additional, Newton-Cheh, Christopher, additional, and Munroe, Patricia B., additional

Published
2021
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321. Assessment of plasma ceramides as predictor for subclinical atherosclerosis

Author

Mishra, Pashupati P., primary, Mishra, Binisha H., additional, Lyytikäinen, Leo-Pekka, additional, Hilvo, Mika, additional, Juonala, Markus, additional, Kähönen, Mika, additional, Hutri-Kähönen, Nina, additional, Fotiadis, Dimitrios I., additional, Raitakari, Olli T., additional, Laaksonen, Reijo, additional, and Lehtimäki, Terho, additional

Published
2021
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323. The Timing and Sequence of Cardiovascular Health Decline

Author

Pool, Lindsay R., primary, Krefman, Amy E., additional, Labarthe, Darwin R., additional, Greenland, Philip, additional, Juonala, Markus, additional, Kähönen, Mika, additional, Lehtimäki, Terho, additional, Day, Rena Sue, additional, Bazzano, Lydia A., additional, Van Horn, Linda, additional, Liu, Lei, additional, Fernandez-Alonso, Camilo, additional, Webber, Larry S., additional, Pahkala, Katja, additional, Laitinen, Tomi T., additional, Raitakari, Olli T., additional, Lloyd-Jones, Donald M., additional, and Allen, Norrina B., additional

Published
2021
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324. Uncovering the shared lipidomic markers of subclinical osteoporosis-atherosclerosis comorbidity: The Young Finns Study

Author

Mishra, Binisha H., primary, Mishra, Pashupati P., additional, Mononen, Nina, additional, Hilvo, Mika, additional, Sievänen, Harri, additional, Juonala, Markus, additional, Laaksonen, Marika, additional, Hutri-Kähönen, Nina, additional, Viikari, Jorma, additional, Kähönen, Mika, additional, Raitakari, Olli T., additional, Laaksonen, Reijo, additional, and Lehtimäki, Terho, additional

Published
2021
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325. Association between Oral Pathology, Carotid Stenosis, and Oral Bacterial DNA in Cerebral Thrombi of Patients with Stroke

Author

Patrakka, Olli, primary, Mehtonen, Helena, additional, Tuomisto, Sari, additional, Pienimäki, Juha-Pekka, additional, Ollikainen, Jyrki, additional, Huhtala, Heini, additional, Pessi, Tanja, additional, Oksala, Niku, additional, Lehtimäki, Terho, additional, Järnstedt, Jorma, additional, Martiskainen, Mika, additional, and Karhunen, Pekka J., additional

Published
2021
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326. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

Author

Shrine, Nick, Izquierdo, Abril G., Chen, Jing, Packer, Richard, Hall, Robert J., Guyatt, Anna L., Batini, Chiara, Thompson, Rebecca J., Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D., Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A., John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y., Chen, Zhengming, Li, Liming, Wijnant, Sara R. A., Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G., Manichaikul, Ani, Oelsner, Elizabeth C., Rich, Stephen S., Barr, R. Graham, Kerr, Shona M., Vitart, Veronique, Brown, Michael R., Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M., Gharib, Sina A., Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E., Meyers, Deborah A., Bleecker, Eugene R., Gabriel, Stacey B., Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F., Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H., Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L., Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T., Thareja, Gaurav, Albagha, Omar M. E., Suhre, Karsten, Granell, Raquel, Faquih, Tariq O., Hiemstra, Pieter S., Slats, Annelies M., Mullin, Benjamin H., Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T., Wyss, Annah B., Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A., Joshi, Peter K., Timmers, Paul R. H. J., Williams, Alexander T., Free, Robert C., Wang, Xueyang, Morrison, John L., Gilliland, Frank D., Chen, Zhanghua, Wang, Carol A., Foong, Rachel E., Harris, Sarah E., Taylor, Adele, Redmond, Paul, Cook, James P., Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T., Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H., Cox, Simon R., Pennell, Craig E., Hall, Graham L., Gauderman, W. James, Brightling, Chris, Wilson, James F., Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O., Timpson, Nicholas J., Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C., Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L., Dudbridge, Frank, Silverman, Edwin K., Strachan, David P., Walters, Robin G., Morris, Andrew P., London, Stephanie J., Cho, Michael H., Wain, Louise V., Hall, Ian P., and Tobin, Martin D.

Abstract

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.

Published
2023
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329. Consumption of meat is associated with higher fasting glucose and insulin concentrations regardless of glucose and insulin genetic risk scores: a meta-analysis of 50,345 Caucasians1,2

Author

Fretts, Amanda M, Follis, Jack L, Nettleton, Jennifer A, Lemaitre, Rozenn N, Ngwa, Julius S, Wojczynski, Mary K, Kalafati, Ioanna Panagiota, Varga, Tibor V, Frazier-Wood, Alexis C, Houston, Denise K, Lahti, Jari, Ericson, Ulrika, van den Hooven, Edith H, Mikkilä, Vera, Kiefte-de Jong, Jessica C, Mozaffarian, Dariush, Rice, Kenneth, Renström, Frida, North, Kari E, McKeown, Nicola M, Feitosa, Mary F, Kanoni, Stavroula, Smith, Caren E, Garcia, Melissa E, Tiainen, Anna-Maija, Sonestedt, Emily, Manichaikul, Ani, van Rooij, Frank JA, Dimitriou, Maria, Raitakari, Olli, Pankow, James S, Djoussé, Luc, Province, Michael A, Hu, Frank B, Lai, Chao-Qiang, Keller, Margaux F, Perälä, Mia-Maria, Rotter, Jerome I, Hofman, Albert, Graff, Misa, Kähönen, Mika, Mukamal, Kenneth, Johansson, Ingegerd, Ordovas, Jose M, Liu, Yongmei, Männistö, Satu, Uitterlinden, André G, Deloukas, Panos, Seppälä, Ilkka, Psaty, Bruce M, Cupples, Adrienne L, Borecki, Ingrid B, Franks, Paul W, Arnett, Donna K, Nalls, Mike A, Eriksson, Johan G, Orho-Melander, Marju, Franco, Oscar H, Lehtimäki, Terho, Dedoussis, George V, Meigs, James B, and Siscovick, David S

Published
2015
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331. Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry

Author

Nettleton, Jennifer A., Follis, Jack L., Ngwa, Julius S., Smith, Caren E., Ahmad, Shafqat, Tanaka, Toshiko, Wojczynski, Mary K., Voortman, Trudy, Lemaitre, Rozenn N., Kristiansson, Kati, Nuotio, Marja-Liisa, Houston, Denise K., Perälä, Mia-Maria, Qi, Qibin, Sonestedt, Emily, Manichaikul, Ani, Kanoni, Stavroula, Ganna, Andrea, Mikkilä, Vera, North, Kari E., Siscovick, David S., Harald, Kennet, Mckeown, Nicola M., Johansson, Ingegerd, Rissanen, Harri, Liu, Yongmei, Lahti, Jari, Hu, Frank B., Bandinelli, Stefania, Rukh, Gull, Rich, Stephen, Booij, Lisanne, Dmitriou, Maria, Ax, Erika, Raitakari, Olli, Mukamal, Kenneth, Männistö, Satu, Hallmans, Göran, Jula, Antti, Ericson, Ulrika, Jacobs, David R., Jr, Van Rooij, Frank J. A., Deloukas, Panos, Sjögren, Per, Kähönen, Mika, Djousse, Luc, Perola, Markus, Barroso, Inês, Hofman, Albert, Stirrups, Kathleen, Viikari, Jorma, Uitterlinden, André G., Kalafati, Ioanna P., Franco, Oscar H., Mozaffarian, Dariush, Salomaa, Veikko, Borecki, Ingrid B., Knekt, Paul, Kritchevsky, Stephen B., Eriksson, Johan G., Dedoussis, George V., Qi, Lu, Ferrucci, Luigi, Orho-Melander, Marju, Zillikens, M. Carola, Ingelsson, Erik, Lehtimäki, Terho, Renström, Frida, Cupples, L. Adrienne, Loos, Ruth J. F., and Franks, Paul W.

Published
2015
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332. Directional dominance on stature and cognition in diverse human populations

Author

Joshi, Peter K., Esko, Tonu, Mattsson, Hannele, Eklund, Niina, Gandin, Ilaria, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Smith, Albert V., Zhang, Weihua, Okada, Yukinori, Stančáková, Alena, Faul, Jessica D., Zhao, Wei, Bartz, Traci M., Concas, Maria Pina, Franceschini, Nora, Enroth, Stefan, Vitart, Veronique, Trompet, Stella, Guo, Xiuqing, Chasman, Daniel I., OʼConnel, Jeffrey R., Corre, Tanguy, Nongmaithem, Suraj S., Chen, Yuning, Mangino, Massimo, Ruggiero, Daniela, Traglia, Michela, Farmaki, Aliki-Eleni, Kacprowski, Tim, Bjonnes, Andrew, van der Spek, Ashley, Wu, Ying, Giri, Anil K., Yanek, Lisa R., Wang, Lihua, Hofer, Edith, Rietveld, Cornelius A., McLeod, Olga, Cornelis, Marilyn C., Pattaro, Cristian, Verweij, Niek, Baumbach, Clemens, Abdellaoui, Abdel, Warren, Helen R., Vuckovic, Dragana, Mei, Hao, Bouchard, Claude, Perry, John R. B., Cappellani, Stefania, Mirza, Saira S., Benton, Miles C., Broeckel, Ulrich, Medland, Sarah E., Lind, Penelope A., Malerba, Giovanni, Drong, Alexander, Yengo, Loic, Bielak, Lawrence F., Zhi, Degui, van der Most, Peter J., Shriner, Daniel, Mägi, Reedik, Hemani, Gibran, Karaderi, Tugce, Wang, Zhaoming, Liu, Tian, Demuth, Ilja, Zhao, Jing Hua, Meng, Weihua, Lataniotis, Lazaros, van der Laan, Sander W., Bradfield, Jonathan P., Wood, Andrew R., Bonnefond, Amelie, Ahluwalia, Tarunveer S., Hall, Leanne M., Salvi, Erika, Yazar, Seyhan, Carstensen, Lisbeth, de Haan, Hugoline G., Abney, Mark, Afzal, Uzma, Allison, Matthew A., Amin, Najaf, Asselbergs, Folkert W., Bakker, Stephan J. L., Barr, Graham R., Baumeister, Sebastian E., Benjamin, Daniel J., Bergmann, Sven, Boerwinkle, Eric, Bottinger, Erwin P., Campbell, Archie, Chakravarti, Aravinda, Chan, Yingleong, Chanock, Stephen J., Chen, Constance, Chen, Ida Y.-D., Collins, Francis S., Connell, John, Correa, Adolfo, Cupples, Adrienne L., Smith, George Davey, Davies, Gail, Dörr, Marcus, Ehret, Georg, Ellis, Stephen B., Feenstra, Bjarke, Feitosa, Mary F., Ford, Ian, Fox, Caroline S., Frayling, Timothy M., Friedrich, Nele, Geller, Frank, Scotland, Generation, Gillham-Nasenya, Irina, Gottesman, Omri, Graff, Misa, Grodstein, Francine, Gu, Charles, Haley, Chris, Hammond, Christopher J., Harris, Sarah E., Harris, Tamara B., Hastie, Nicholas D., Heard-Costa, Nancy L., Heikkilä, Kauko, Hocking, Lynne J., Homuth, Georg, Hottenga, Jouke-Jan, Huang, Jinyan, Huffman, Jennifer E., Hysi, Pirro G., Ikram, Arfan M., Ingelsson, Erik, Joensuu, Anni, Johansson, Åsa, Jousilahti, Pekka, Jukema, Wouter J., Kähönen, Mika, Kamatani, Yoichiro, Kanoni, Stavroula, Kerr, Shona M., Khan, Nazir M., Koellinger, Philipp, Koistinen, Heikki A., Kooner, Manraj K., Kubo, Michiaki, Kuusisto, Johanna, Lahti, Jari, Launer, Lenore J., Lea, Rodney A., Lehne, Benjamin, Lehtimäki, Terho, Liewald, David C.M., Lind, Lars, Loh, Marie, Lokki, Marja-Liisa, London, Stephanie J., Loomis, Stephanie J., Loukola, Anu, Lu, Yingchang, Lumley, Thomas, Lundqvist, Annamari, Männistö, Satu, Marques-Vidal, Pedro, Masciullo, Corrado, Matchan, Angela, Mathias, Rasika A., Matsuda, Koichi, Meigs, James B., Meisinger, Christa, Meitinger, Thomas, Menni, Cristina, Mentch, Frank D., Mihailov, Evelin, Milani, Lili, Montasser, May E., Montgomery, Grant W., Morrison, Alanna, Myers, Richard H., Nadukuru, Rajiv, Navarro, Pau, Nelis, Mari, Nieminen, Markku S., Nolte, Ilja M., OʼConnor, George T., Ogunniyi, Adesola, Padmanabhan, Sandosh, Palmas, Walter R., Pankow, James S., Patarcic, Inga, Pavani, Francesca, Peyser, Patricia A., Pietilainen, Kirsi, Poulter, Neil, Prokopenko, Inga, Ralhan, Sarju, Redmond, Paul, Rich, Stephen S., Rissanen, Harri, Robino, Antonietta, Rose, Lynda M., Rose, Richard, Sala, Cinzia, Salako, Babatunde, Salomaa, Veikko, Sarin, Antti-Pekka, Saxena, Richa, Schmidt, Helena, Scott, Laura J., Scott, William R., Sennblad, Bengt, Seshadri, Sudha, Sever, Peter, Shrestha, Smeeta, Smith, Blair H., Smith, Jennifer A., Soranzo, Nicole, Sotoodehnia, Nona, Southam, Lorraine, Stanton, Alice V., Stathopoulou, Maria G., Strauch, Konstantin, Strawbridge, Rona J., Suderman, Matthew J., Tandon, Nikhil, Tang, Sian-Tsun, Taylor, Kent D., Tayo, Bamidele O., Töglhofer, Anna Maria, Tomaszewski, Maciej, Tšernikova, Natalia, Tuomilehto, Jaakko, Uitterlinden, Andre G., Vaidya, Dhananjay, van Hylckama Vlieg, Astrid, van Setten, Jessica, Vasankari, Tuula, Vedantam, Sailaja, Vlachopoulou, Efthymia, Vozzi, Diego, Vuoksimaa, Eero, Waldenberger, Melanie, Ware, Erin B., Wentworth-Shields, William, Whitfield, John B., Wild, Sarah, Willemsen, Gonneke, Yajnik, Chittaranjan S., Yao, Jie, Zaza, Gianluigi, Zhu, Xiaofeng, Salem, Rany M., Melbye, Mads, Bisgaard, Hans, Samani, Nilesh J., Cusi, Daniele, Mackey, David A., Cooper, Richard S., Froguel, Philippe, Pasterkamp, Gerard, Grant, Struan F.A., Hakonarson, Hakon, Ferrucci, Luigi, Scott, Robert A., Morris, Andrew D., Palmer, Colin N. A., Dedoussis, George, Deloukas, Panos, Bertram, Lars, Lindenberger, Ulman, Berndt, Sonja I., Lindgren, Cecilia M., Timpson, Nicholas J., Tönjes, Anke, Munroe, Patricia B., Sørensen, Thorkild I. A., Rotimi, Charles N., Arnett, Donna K., Oldehinkel, Albertine J., Kardia, Sharon L. R., Balkau, Beverley, Gambaro, Giovanni, Morris, Andrew P., Eriksson, Johan G., Wright, Margie J., Martin, Nicholas G., Hunt, Steven C., Starr, John M., Deary, Ian J., Griffiths, Lyn R., Tiemeier, Henning, Pirastu, Nicola, Kaprio, Jaakko, Wareham, Nicholas J., Pérusse, Louis, Wilson, James G., Girotto, Giorgia, Caulfield, Mark J., Raitakari, Olli, Boomsma, Dorret I., Gieger, Christian, van der Harst, Pim, Hicks, Andrew A., Kraft, Peter, Sinisalo, Juha, Knekt, Paul, Johannesson, Magnus, Magnusson, Patrik K. E., Hamsten, Anders, Schmidt, Reinhold, Borecki, Ingrid B., Vartiainen, Erkki, Becker, Diane M., Bharadwaj, Dwaipayan, Mohlke, Karen L., Boehnke, Michael, van Duijn, Cornelia M., Sanghera, Dharambir K., Teumer, Alexander, Zeggini, Eleftheria, Metspalu, Andres, Gasparini, Paolo, Ulivi, Sheila, Ober, Carole, Toniolo, Daniela, Rudan, Igor, Porteous, David J., Ciullo, Marina, Spector, Tim D., Hayward, Caroline, Dupuis, Josée, Loos, Ruth J. F., Wright, Alan F., Chandak, Giriraj R., Vollenweider, Peter, Shuldiner, Alan R., Ridker, Paul M., Rotter, Jerome I., Sattar, Naveed, Gyllensten, Ulf, North, Kari E., Pirastu, Mario, Psaty, Bruce M., Weir, David R., Laakso, Markku, Gudnason, Vilmundur, Takahashi, Atsushi, Chambers, John C., Kooner, Jaspal S., Strachan, David P., Campbell, Harry, Hirschhorn, Joel N., Perola, Markus, Polašek, Ozren, and Wilson, James F.

Published
2015
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333. Predicting sudden cardiac death using common genetic risk variants for coronary artery disease

Author

Hernesniemi, Jussi A., Lyytikäinen, Leo-Pekka, Oksala, Niku, Seppälä, Ilkka, Kleber, Marcus E., Mononen, Nina, März, Winfried, Mikkelsson, Jussi, Pessi, Tanja, Louhelainen, Anne-Mari, Martiskainen, Mika, Nikus, Kjell, Klopp, Norman, Waldenberger, Melanie, Illig, Thomas, Kähönen, Mika, Laaksonen, Reijo, Karhunen, Pekka J., and Lehtimäki, Terho

Published
2015
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334. Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder

Author

de Moor, Marleen H. M., van den Berg, Stéphanie M., Verweij, Karin J. H., Krueger, Robert F., Luciano, Michelle, Arias Vasquez, Alejandro, Matteson, Lindsay K., Derringer, Jaime, Esko, Tõnu, Amin, Najaf, Gordon, Scott D., Hansell, Narelle K., Hart, Amy B., Seppälä, Ilkka, Huffman, Jennifer E., Konte, Bettina, Lahti, Jari, Lee, Minyoung, Miller, Mike, Nutile, Teresa, Tanaka, Toshiko, Teumer, Alexander, Viktorin, Alexander, Wedenoja, Juho, Abecasis, Goncalo R., Adkins, Daniel E., Agrawal, Arpana, Allik, Jüri, Appel, Katja, Bigdeli, Timothy B., Busonero, Fabio, Campbell, Harry, Costa, Paul T., Davey Smith, George, Davies, Gail, de Wit, Harriet, Ding, Jun, Engelhardt, Barbara E., Eriksson, Johan G., Fedko, Iryna O., Ferrucci, Luigi, Franke, Barbara, Giegling, Ina, Grucza, Richard, Hartmann, Annette M., Heath, Andrew C., Heinonen, Kati, Henders, Anjali K., Homuth, Georg, Hottenga, Jouke-Jan, Iacono, William G., Janzing, Joost, Jokela, Markus, Karlsson, Robert, Kemp, John P., Kirkpatrick, Matthew G., Latvala, Antti, Lehtimäki, Terho, Liewald, David C., Madden, Pamela A. F., Magri, Chiara, Magnusson, Patrik K. E., Marten, Jonathan, Maschio, Andrea, Medland, Sarah E., Mihailov, Evelin, Milaneschi, Yuri, Montgomery, Grant W., Nauck, Matthias, Ouwens, Klaasjan G., Palotie, Aarno, Pettersson, Erik, Polasek, Ozren, Qian, Yong, Pulkki-Råback, Laura, Raitakari, Olli T., Realo, Anu, Rose, Richard J., Ruggiero, Daniela, Schmidt, Carsten O., Slutske, Wendy S., Sorice, Rossella, Starr, John M., St Pourcain, Beate, Sutin, Angelina R., Timpson, Nicholas J., Trochet, Holly, Vermeulen, Sita, Vuoksimaa, Eero, Widen, Elisabeth, Wouda, Jasper, Wright, Margaret J., Zgaga, Lina, Porteous, David, Minelli, Alessandra, Palmer, Abraham A., Rujescu, Dan, Ciullo, Marina, Hayward, Caroline, Rudan, Igor, Metspalu, Andres, Kaprio, Jaakko, Deary, Ian J., Räikkönen, Katri, Wilson, James F., Keltikangas-Järvinen, Liisa, Bierut, Laura J., Hettema, John M., Grabe, Hans J., van Duijn, Cornelia M., Evans, David M., Schlessinger, David, Pedersen, Nancy L., Terracciano, Antonio, McGue, Matt, Penninx, Brenda W. J. H., Martin, Nicholas G., and Boomsma, Dorret I.

Published
2015
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335. Genetically Determined Height and Coronary Artery Disease

Author

Nelson, Christopher P., Hamby, Stephen E., Saleheen, Danish, Hopewell, Jenna C., Zeng, Lingyao, Assimes, Themistocles L., Kanoni, Stavroula, Willenborg, Christina, Burgess, Stephen, Amouyel, Phillipe, Anand, Sonia, Blankenberg, Stefan, Boehm, Bernhard O., Clarke, Robert J., Collins, Rory, Dedoussis, George, Farrall, Martin, Franks, Paul W., Groop, Leif, Hall, Alistair S., Hamsten, Anders, Hengstenberg, Christian, Hovingh, Kees G., Ingelsson, Erik, Kathiresan, Sekar, Kee, Frank, König, Inke R., Kooner, Jaspal, Lehtimäki, Terho, März, Winifred, McPherson, Ruth, Metspalu, Andres, Nieminen, Markku S., OʼDonnell, Christopher J., Palmer, Colin N.A., Peters, Annette, Perola, Markus, Reilly, Muredach P., Ripatti, Samuli, Roberts, Robert, Salomaa, Veikko, Shah, Svati H., Schreiber, Stefan, Siegbahn, Agneta, Thorsteinsdottir, Unnur, Veronesi, Giovani, Wareham, Nicholas, Willer, Cristen J., Zalloua, Pierre A., Erdmann, Jeanette, Deloukas, Panos, Watkins, Hugh, Schunkert, Heribert, Danesh, John, Thompson, John R., and Samani, Nilesh J.

Published
2015
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336. Sex hormone-binding globulin associations with circulating lipids and metabolites and the risk for type 2 diabetes: observational and causal effect estimates

Author

Wang, Qin, Kangas, Antti J, Soininen, Pasi, Tiainen, Mika, Tynkkynen, Tuulia, Puukka, Katri, Ruokonen, Aimo, Viikari, Jorma, Kähönen, Mika, Lehtimäki, Terho, Salomaa, Veikko, Perola, Markus, Davey Smith, George, Raitakari, Olli T, Järvelin, Marjo-Riitta, Würtz, Peter, Kettunen, Johannes, and Ala-Korpela, Mika

Published
2015
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337. Genetic studies of body mass index yield new insights for obesity biology

Author

Locke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jianʼan, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Hua Zhao, Jing, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Åsa K., Karjalainen, Juha, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bolton, Jennifer L., Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Deng, Guohong, Ehret, Georg B., Feenstra, Bjarke, Feitosa, Mary F., Fischer, Krista, Goel, Anuj, Gong, Jian, Jackson, Anne U., Kanoni, Stavroula, Kleber, Marcus E., Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Medland, Sarah E., Nalls, Michael A., Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Shungin, Dmitry, Stančáková, Alena, Strawbridge, Rona J., Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W., van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V., Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Isaacs, Aaron, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Attwood, Antony P., Bandinelli, Stefania, Barrett, Amy, Bas, Isabelita N., Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blagieva, Roza, Blüher, Matthias, Böhringer, Stefan, Bonnycastle, Lori L., Böttcher, Yvonne, Boyd, Heather A., Bruinenberg, Marcel, Caspersen, Ida H., Ida Chen, Yii-Der, Clarke, Robert, Warwick Daw, E., de Craen, Anton J. M., Delgado, Graciela, Dimitriou, Maria, Doney, Alex S. F., Eklund, Niina, Estrada, Karol, Eury, Elodie, Folkersen, Lasse, Fraser, Ross M., Garcia, Melissa E., Geller, Frank, Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Goodall, Alison H., Gordon, Scott D., Gorski, Mathias, Grabe, Hans-Jörgen, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grönberg, Henrik, Groves, Christopher J., Gusto, Gaëlle, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L., Helmer, Quinta, Hengstenberg, Christian, Holmen, Oddgeir, Hottenga, Jouke-Jan, James, Alan L., Jeff, Janina M., Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Kinnunen, Leena, Koenig, Wolfgang, Koskenvuo, Markku, Kratzer, Wolfgang, Laitinen, Jaana, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Sin Lo, Ken, Lobbens, Stéphane, Lorbeer, Roberto, Lu, Yingchang, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., McLachlan, Stela, Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Moayyeri, Alireza, Monda, Keri L., Morken, Mario A., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W., Nagaraja, Ramaiah, Nöthen, Markus M., Nolte, Ilja M., Pilz, Stefan, Rayner, Nigel W., Renstrom, Frida, Rettig, Rainer, Ried, Janina S., Ripke, Stephan, Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R., Scott, William R., Seufferlein, Thomas, Shi, Jianxin, Vernon Smith, Albert, Smolonska, Joanna, Stanton, Alice V., Steinthorsdottir, Valgerdur, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tan, Sian-Tsung, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tyrer, Jonathan P., Uh, Hae-Won, Vandenput, Liesbeth, Verhulst, Frank C., Vermeulen, Sita H., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Warren, Helen R., Waterworth, Dawn, Weedon, Michael N., Wilkens, Lynne R., Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Wright, Alan F., Zhang, Qunyuan, Brennan, Eoin P., Choi, Murim, Dastani, Zari, Drong, Alexander W., Eriksson, Per, Franco-Cereceda, Anders, Gådin, Jesper R., Gharavi, Ali G., Goddard, Michael E., Handsaker, Robert E., Huang, Jinyan, Karpe, Fredrik, Kathiresan, Sekar, Keildson, Sarah, Kiryluk, Krzysztof, Kubo, Michiaki, Lee, Jong-Young, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McCarroll, Steven A., McKnight, Amy J., Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Okada, Yukinori, Perry, John R. B., Dorajoo, Rajkumar, Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Scott, Robert A., Stolk, Lisette, Takahashi, Atsushi, Tanaka, Toshihiro, vanʼt Hooft, Ferdinand M., Vinkhuyzen, Anna A. E., Westra, Harm-Jan, Zheng, Wei, Zondervan, Krina T., Heath, Andrew C., Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Bovet, Pascal, Campbell, Harry, Caulfield, Mark J., Cesana, Giancarlo, Chakravarti, Aravinda, Chasman, Daniel I., Chines, Peter S., Collins, Francis S., Crawford, Dana C., Adrienne Cupples, L., Cusi, Daniele, Danesh, John, de Faire, Ulf, den Ruijter, Hester M., Dominiczak, Anna F., Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G., Farrall, Martin, Felix, Stephan B., Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gejman, Pablo V., Gieger, Christian, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Hall, Alistair S., Harris, Tamara B., Hattersley, Andrew T., Hicks, Andrew A., Hindorff, Lucia A., Hingorani, Aroon D., Hofman, Albert, Homuth, Georg, Kees Hovingh, G., Humphries, Steve E., Hunt, Steven C., Hyppönen, Elina, Illig, Thomas, Jacobs, Kevin B., Jarvelin, Marjo-Riitta, Jöckel, Karl-Heinz, Johansen, Berit, Jousilahti, Pekka, Wouter Jukema, J., Jula, Antti M., Kaprio, Jaakko, Kastelein, John J. P., Keinanen-Kiukaanniemi, Sirkka M., Kiemeney, Lambertus A., Knekt, Paul, Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Moll, Frans L., Morris, Andrew D., Morris, Andrew P., Murray, Jeffrey C., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Madden, Pamela A. F., Pasterkamp, Gerard, Peden, John F., Peters, Annette, Postma, Dirkje S., Pramstaller, Peter P., Price, Jackie F., Qi, Lu, Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Rioux, John D., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schunkert, Heribert, Schwarz, Peter E. H., Sever, Peter, Shuldiner, Alan R., Sinisalo, Juha, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Trégouët, David-Alexandre, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Völker, Uwe, Waeber, Gérard, Willemsen, Gonneke, Witteman, Jacqueline C., Carola Zillikens, M., Adair, Linda S., Amouyel, Philippe, Asselbergs, Folkert W., Assimes, Themistocles L., Bochud, Murielle, Boehm, Bernhard O., Boerwinkle, Eric, Bornstein, Stefan R., Bottinger, Erwin P., Bouchard, Claude, Cauchi, Stéphane, Chambers, John C., Chanock, Stephen J., Cooper, Richard S., de Bakker, Paul I. W., Dedoussis, George, Ferrucci, Luigi, Franks, Paul W., Froguel, Philippe, Groop, Leif C., Haiman, Christopher A., Hamsten, Anders, Hui, Jennie, Hunter, David J., Hveem, Kristian, Kaplan, Robert C., Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G., März, Winfried, Melbye, Mads, Metspalu, Andres, Moebus, Susanne, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sattar, Naveed, Schadt, Eric E., Schlessinger, David, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Walker, Mark, Wallaschofski, Henri, Wareham, Nicholas J., Watkins, Hugh, Weir, David R., Wichmann, H-Erich, Wilson, James F., Zanen, Pieter, Borecki, Ingrid B., Deloukas, Panos, Fox, Caroline S., Heid, Iris M., OʼConnell, Jeffrey R., Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Abecasis, Gonçalo R., Franke, Lude, Frayling, Timothy M., McCarthy, Mark I., Visscher, Peter M., Scherag, André, Willer, Cristen J., Boehnke, Michael, Mohlke, Karen L., Lindgren, Cecilia M., Beckmann, Jacques S., Barroso, Inês, North, Kari E., Ingelsson, Erik, Hirschhorn, Joel N., Loos, Ruth J. F., and Speliotes, Elizabeth K.

Published
2015
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338. New genetic loci link adipose and insulin biology to body fat distribution

Author

Shungin, Dmitry, Winkler, Thomas W., Croteau-Chonka, Damien C., Ferreira, Teresa, Locke, Adam E., Mägi, Reedik, Strawbridge, Rona J., Pers, Tune H., Fischer, Krista, Justice, Anne E., Workalemahu, Tsegaselassie, Wu, Joseph M. W., Buchkovich, Martin L., Heard-Costa, Nancy L., Roman, Tamara S., Drong, Alexander W., Song, Ci, Gustafsson, Stefan, Day, Felix R., Esko, Tonu, Fall, Tove, Kutalik, Zoltán, Luan, Jianʼan, Randall, Joshua C., Scherag, André, Vedantam, Sailaja, Wood, Andrew R., Chen, Jin, Fehrmann, Rudolf, Karjalainen, Juha, Kahali, Bratati, Liu, Ching-Ti, Schmidt, Ellen M., Absher, Devin, Amin, Najaf, Anderson, Denise, Beekman, Marian, Bragg-Gresham, Jennifer L., Buyske, Steven, Demirkan, Ayse, Ehret, Georg B., Feitosa, Mary F., Goel, Anuj, Jackson, Anne U., Johnson, Toby, Kleber, Marcus E., Kristiansson, Kati, Mangino, Massimo, Mateo Leach, Irene, Medina-Gomez, Carolina, Palmer, Cameron D., Pasko, Dorota, Pechlivanis, Sonali, Peters, Marjolein J., Prokopenko, Inga, Stančáková, Alena, Ju Sung, Yun, Tanaka, Toshiko, Teumer, Alexander, Van Vliet-Ostaptchouk, Jana V., Yengo, Loïc, Zhang, Weihua, Albrecht, Eva, Ärnlöv, Johan, Arscott, Gillian M., Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J., Berne, Christian, Blüher, Matthias, Böhringer, Stefan, Bonnet, Fabrice, Böttcher, Yvonne, Bruinenberg, Marcel, Carba, Delia B., Caspersen, Ida H., Clarke, Robert, Warwick Daw, E., Deelen, Joris, Deelman, Ewa, Delgado, Graciela, Doney, Alex S. F., Eklund, Niina, Erdos, Michael R., Estrada, Karol, Eury, Elodie, Friedrich, Nele, Garcia, Melissa E., Giedraitis, Vilmantas, Gigante, Bruna, Go, Alan S., Golay, Alain, Grallert, Harald, Grammer, Tanja B., Gräler, Jürgen, Grewal, Jagvir, Groves, Christopher J., Haller, Toomas, Hallmans, Goran, Hartman, Catharina A., Hassinen, Maija, Hayward, Caroline, Heikkilä, Kauko, Herzig, Karl-Heinz, Helmer, Quinta, Hillege, Hans L., Holmen, Oddgeir, Hunt, Steven C., Isaacs, Aaron, Ittermann, Till, James, Alan L., Johansson, Ingegerd, Juliusdottir, Thorhildur, Kalafati, Ioanna-Panagiota, Kinnunen, Leena, Koenig, Wolfgang, Kooner, Ishminder K., Kratzer, Wolfgang, Lamina, Claudia, Leander, Karin, Lee, Nanette R., Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Mach, François, Magnusson, Patrik K. E., Mahajan, Anubha, McArdle, Wendy L., Menni, Cristina, Merger, Sigrun, Mihailov, Evelin, Milani, Lili, Mills, Rebecca, Moayyeri, Alireza, Monda, Keri L., Mooijaart, Simon P., Mühleisen, Thomas W., Mulas, Antonella, Müller, Gabriele, Müller-Nurasyid, Martina, Nagaraja, Ramaiah, Nalls, Michael A., Narisu, Narisu, Glorioso, Nicola, Nolte, Ilja M., Olden, Matthias, Rayner, Nigel W., Renstrom, Frida, Ried, Janina S., Robertson, Neil R., Rose, Lynda M., Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Sennblad, Bengt, Seufferlein, Thomas, Sitlani, Colleen M., Vernon Smith, Albert, Stirrups, Kathleen, Stringham, Heather M., Sundström, Johan, Swertz, Morris A., Swift, Amy J., Syvänen, Ann-Christine, Tayo, Bamidele O., Thorand, Barbara, Thorleifsson, Gudmar, Tomaschitz, Andreas, Troffa, Chiara, van Oort, Floor V. A., Verweij, Niek, Vonk, Judith M., Waite, Lindsay L., Wennauer, Roman, Wilsgaard, Tom, Wojczynski, Mary K., Wong, Andrew, Zhang, Qunyuan, Hua Zhao, Jing, Brennan, Eoin P., Choi, Murim, Eriksson, Per, Folkersen, Lasse, Franco-Cereceda, Anders, Gharavi, Ali G., Hedman, Åsa K., Hivert, Marie-France, Huang, Jinyan, Kanoni, Stavroula, Karpe, Fredrik, Keildson, Sarah, Kiryluk, Krzysztof, Liang, Liming, Lifton, Richard P., Ma, Baoshan, McKnight, Amy J., McPherson, Ruth, Metspalu, Andres, Min, Josine L., Moffatt, Miriam F., Montgomery, Grant W., Murabito, Joanne M., Nicholson, George, Nyholt, Dale R., Olsson, Christian, Perry, John R. B., Reinmaa, Eva, Salem, Rany M., Sandholm, Niina, Schadt, Eric E., Scott, Robert A., Stolk, Lisette, Vallejo, Edgar E., Westra, Harm-Jan, Zondervan, Krina T., Amouyel, Philippe, Arveiler, Dominique, Bakker, Stephan J. L., Beilby, John, Bergman, Richard N., Blangero, John, Brown, Morris J., Burnier, Michel, Campbell, Harry, Chakravarti, Aravinda, Chines, Peter S., Claudi-Boehm, Simone, Collins, Francis S., Crawford, Dana C., Danesh, John, de Faire, Ulf, de Geus, Eco J. C., Dörr, Marcus, Erbel, Raimund, Eriksson, Johan G., Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Forouhi, Nita G., Forrester, Terrence, Franco, Oscar H., Gansevoort, Ron T., Gieger, Christian, Gudnason, Vilmundur, Haiman, Christopher A., Harris, Tamara B., Hattersley, Andrew T., Heliövaara, Markku, Hicks, Andrew A., Hingorani, Aroon D., Hoffmann, Wolfgang, Hofman, Albert, Homuth, Georg, Humphries, Steve E., Hyppönen, Elina, Illig, Thomas, Jarvelin, Marjo-Riitta, Johansen, Berit, Jousilahti, Pekka, Jula, Antti M., Kaprio, Jaakko, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M., Kooner, Jaspal S., Kooperberg, Charles, Kovacs, Peter, Kraja, Aldi T., Kumari, Meena, Kuulasmaa, Kari, Kuusisto, Johanna, Lakka, Timo A., Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lyssenko, Valeriya, Männistö, Satu, Marette, André, Matise, Tara C., McKenzie, Colin A., McKnight, Barbara, Musk, Arthur W., Möhlenkamp, Stefan, Morris, Andrew D., Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J., Ong, Ken K., Palmer, Lyle J., Penninx, Brenda W., Peters, Annette, Pramstaller, Peter P., Raitakari, Olli T., Rankinen, Tuomo, Rao, D. C., Rice, Treva K., Ridker, Paul M., Ritchie, Marylyn D., Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J., Saramies, Jouko, Sarzynski, Mark A., Schwarz, Peter E. H., Shuldiner, Alan R., Staessen, Jan A., Steinthorsdottir, Valgerdur, Stolk, Ronald P., Strauch, Konstantin, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Vohl, Marie-Claude, Völker, Uwe, Vollenweider, Peter, Wilson, James F., Witteman, Jacqueline C., Adair, Linda S., Bochud, Murielle, Boehm, Bernhard O., Bornstein, Stefan R., Bouchard, Claude, Cauchi, Stéphane, Caulfield, Mark J., Chambers, John C., Chasman, Daniel I., Cooper, Richard S., Dedoussis, George, Ferrucci, Luigi, Froguel, Philippe, Grabe, Hans-Jörgen, Hamsten, Anders, Hui, Jennie, Hveem, Kristian, Jöckel, Karl-Heinz, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, März, Winfried, Munroe, Patricia B., Njølstad, Inger, Oostra, Ben A., Palmer, Colin N. A., Pedersen, Nancy L., Perola, Markus, Pérusse, Louis, Peters, Ulrike, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Rivadeneira, Fernando, Saaristo, Timo E., Saleheen, Danish, Sinisalo, Juha, Eline Slagboom, P., Snieder, Harold, Spector, Tim D., Thorsteinsdottir, Unnur, Stumvoll, Michael, Tuomilehto, Jaakko, Uitterlinden, André G., Uusitupa, Matti, van der Harst, Pim, Veronesi, Giovanni, Walker, Mark, Wareham, Nicholas J., Watkins, Hugh, Wichmann, H-Erich, Abecasis, Goncalo R., Assimes, Themistocles L., Berndt, Sonja I., Boehnke, Michael, Borecki, Ingrid B., Deloukas, Panos, Franke, Lude, Frayling, Timothy M., Groop, Leif C., Hunter, David J., Kaplan, Robert C., OʼConnell, Jeffrey R., Qi, Lu, Schlessinger, David, Strachan, David P., Stefansson, Kari, van Duijn, Cornelia M., Willer, Cristen J., Visscher, Peter M., Yang, Jian, Hirschhorn, Joel N., Carola Zillikens, M., McCarthy, Mark I., Speliotes, Elizabeth K., North, Kari E., Fox, Caroline S., Barroso, Inês, Franks, Paul W., Ingelsson, Erik, Heid, Iris M., Loos, Ruth J. F., Cupples, Adrienne L., Morris, Andrew P., Lindgren, Cecilia M., and Mohlke, Karen L

Published
2015
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339. Habitual sleep duration is associated with BMI and macronutrient intake and may be modified by CLOCK genetic variants1-5

Author

Dashti, Hassan S, Follis, Jack L, Smith, Caren E, Tanaka, Toshiko, Cade, Brian E, Gottlieb, Daniel J, Hruby, Adela, Jacques, Paul F, Lamon-Fava, Stefania, Richardson, Kris, Saxena, Richa, Scheer, Frank AJL, Kovanen, Leena, Bartz, Traci M, Perälä, Mia-Maria, Jonsson, Anna, Frazier-Wood, Alexis C, Kalafati, Ioanna-Panagiota, Mikkilä, Vera, Partonen, Timo, Lemaitre, Rozenn N, Lahti, Jari, Hernandez, Dena G, Toft, Ulla, Johnson, Craig W, Kanoni, Stavroula, Raitakari, Olli T, Perola, Markus, Psaty, Bruce M, Ferrucci, Luigi, Grarup, Niels, Highland, Heather M, Rallidis, Loukianos, Kähönen, Mika, Havulinna, Aki S, Siscovick, David S, Räikkönen, Katri, Jørgensen, Torben, Rotter, Jerome I, Deloukas, Panos, Viikari, Jorma SA, Mozaffarian, Dariush, Linneberg, Allan, Seppälä, Ilkka, Hansen, Torben, Salomaa, Veikko, Gharib, Sina A, Eriksson, Johan G, Bandinelli, Stefania, Pedersen, Oluf, Rich, Stephen S, Dedoussis, George, Lehtimäki, Terho, and Ordovás, José M

Published
2015
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340. Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline

Author

Gorski, Mathias, Jung, Bettina, Li, Yong, Matias-Garcia, Pamela R, Wuttke, Matthias, Coassin, Stefan, Thio, Chris HL, Kleber, Marcus E, Winkler, Thomas W, Wanner, Veronika, Chai, Jin-Fang, Chu, Audrey Y, Cocca, Massimiliano, Feitosa, Mary F, Ghasemi, Sahar, Hoppmann, Anselm, Horn, Katrin, Li, Man, Nutile, Teresa, Scholz, Markus, Sieber, Karsten B, Teumer, Alexander, Tin, Adrienne, Wang, Judy, Tayo, Bamidele O, Ahluwalia, Tarunveer S, Almgren, Peter, Bakker, Stephan JL, Banas, Bernhard, Bansal, Nisha, Biggs, Mary L, Boerwinkle, Eric, Bottinger, Erwin P, Brenner, Hermann, Carroll, Robert J, Chalmers, John, Chee, Miao-Li, Chee, Miao-Ling, Cheng, Ching-Yu, Coresh, Josef, de Borst, Martin H, Degenhardt, Frauke, Eckardt, Kai-Uwe, Endlich, Karlhans, Franke, Andre, Freitag-Wolf, Sandra, Gampawar, Piyush, Gansevoort, Ron T, Ghanbari, Mohsen, Gieger, Christian, Hamet, Pavel, Ho, Kevin, Hofer, Edith, Holleczek, Bernd, Xian Foo, Valencia Hui, Hutri-Kähönen, Nina, Hwang, Shih-Jen, Ikram, M Arfan, Josyula, Navya Shilpa, Kähönen, Mika, Khor, Chiea-Chuen, Koenig, Wolfgang, Kramer, Holly, Krämer, Bernhard K, Kühnel, Brigitte, Lange, Leslie A, Lehtimäki, Terho, Lieb, Wolfgang, Lifelines Cohort Study, Regeneron Genetics Center, Loos, Ruth JF, Lukas, Mary Ann, Lyytikäinen, Leo-Pekka, Meisinger, Christa, Meitinger, Thomas, Melander, Olle, Milaneschi, Yuri, Mishra, Pashupati P, Mononen, Nina, Mychaleckyj, Josyf C, Nadkarni, Girish N, Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, Ilja M, O'Donoghue, Michelle L, Orho-Melander, Marju, Pendergrass, Sarah A, Penninx, Brenda WJH, Preuss, Michael H, Psaty, Bruce M, Raffield, Laura M, Raitakari, Olli T, Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M, Rosenkranz, Alexander R, Rossing, Peter, Rotter, Jerome I, and Sabanayagam, Charumathi

Subjects
genome-wide association study, Kidney Disease, Prevention, Human Genome, Clinical Sciences, Protein Disulfide-Isomerases, Renal and urogenital, AMP-Activated Protein Kinases, Urology & Nephrology, Regeneron Genetics Center, Kidney, United Kingdom, Rare Diseases, Lifelines Cohort Study, acute kidney injury, Creatinine, end-stage kidney disease, rapid eGFRcrea decline, Genetics, Humans, 2.1 Biological and endogenous factors, Aetiology, Glomerular Filtration Rate
Abstract

Rapid decline of glomerular filtration rate estimated from creatinine (eGFRcrea) is associated with severe clinical endpoints. In contrast to cross-sectionally assessed eGFRcrea, the genetic basis for rapid eGFRcrea decline is largely unknown. To help define this, we meta-analyzed 42 genome-wide association studies from the Chronic Kidney Diseases Genetics Consortium and United Kingdom Biobank to identify genetic loci for rapid eGFRcrea decline. Two definitions of eGFRcrea decline were used: 3 mL/min/1.73m2/year or more ("Rapid3"; encompassing 34,874 cases, 107,090 controls) and eGFRcrea decline 25% or more and eGFRcrea under 60 mL/min/1.73m2 at follow-up among those with eGFRcrea 60 mL/min/1.73m2 or more at baseline ("CKDi25"; encompassing 19,901 cases, 175,244 controls). Seven independent variants were identified across six loci for Rapid3 and/or CKDi25: consisting of five variants at four loci with genome-wide significance (near UMOD-PDILT (2), PRKAG2, WDR72, OR2S2) and two variants among 265 known eGFRcrea variants (near GATM, LARP4B). All these loci were novel for Rapid3 and/or CKDi25 and our bioinformatic follow-up prioritized variants and genes underneath these loci. The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates. For the five genome-wide significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk (8-14 vs. 0-5 adverse alleles) had a 1.20-fold increased risk of acute kidney injury (95% confidence interval 1.08-1.33). Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.

Published
2021

341. Adulthood blood levels of hsa-miR-29b-3p associate with preterm birth and adult metabolic and cognitive health

Author

Marttila, Saara, Rovio, Suvi, Mishra, Pashupati P., Seppälä, Ilkka, Lyytikäinen, Leo-Pekka, Juonala, Markus, Waldenberger, Melanie, Oksala, Niku, Ala-Korpela, Mika, Harville, Emily, Hutri-Kähönen, Nina, Kähönen, Mika, Raitakari, Olli, Lehtimäki, Terho, Raitoharju, Emma, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Verisuoni- ja toimenpideradiologinen keskus, Department of Paediatrics, and Department of Clinical Physiology and Nuclear Medicine

Subjects
Adult, Male, Adolescent, Science, 3121 Internal medicine, Article, Metabolic Diseases, Pregnancy, Humans, Cognitive Dysfunction, Child, Finland, Gene Expression Profiling, Infant, Newborn, Type 2 diabetes, Middle Aged, Prognosis, 3126 Surgery, anesthesiology, intensive care, radiology, Gene regulation, MicroRNAs, Diabetes Mellitus, Type 2, Child, Preschool, miRNAs, Premature Birth, Medicine, Female, Gene expression, 3111 Biomedicine, Biomarkers, Follow-Up Studies, Signal Transduction
Abstract

Preterm birth (PTB) is associated with increased risk of type 2 diabetes and neurocognitive impairment later in life. We analyzed for the first time the associations of PTB with blood miRNA levels in adulthood. We also investigated the relationship of PTB associated miRNAs and adulthood phenotypes previously linked with premature birth. Blood MicroRNA profiling, genome-wide gene expression analysis, computer-based cognitive testing battery (CANTAB) and serum NMR metabolomics were performed for Young Finns Study subjects (aged 34–49 years, full-term n = 682, preterm n = 84). Preterm birth (vs. full-term) was associated with adulthood levels of hsa-miR-29b-3p in a fully adjusted regression model (p = 1.90 × 10–4, FDR = 0.046). The levels of hsa-miR-29b-3p were down-regulated in subjects with PTB with appropriate birthweight for gestational age (p = 0.002, fold change [FC] = − 1.20) and specifically in PTB subjects with small birthweight for gestational age (p = 0.095, FC = − 1.39) in comparison to individuals born full term. Hsa-miR-29b-3p levels correlated with the expressions of its target-mRNAs BCL11A and CS and the gene set analysis results indicated a target-mRNA driven association between hsa-miR-29b-3p levels and Alzheimer's disease, Parkinson's disease, Insulin signaling and Regulation of Actin Cytoskeleton pathway expression. The level of hsa-miR-29b-3p was directly associated with visual processing and sustained attention in CANTAB test and inversely associated with serum levels of VLDL subclass component and triglyceride levels. In conlcusion, adult blood levels of hsa-miR-29b-3p were lower in subjects born preterm. Hsa-miR-29b-3p associated with cognitive function and may be linked with adulthood morbidities in subjects born preterm, possibly through regulation of gene sets related to neurodegenerative diseases and insulin signaling as well as VLDL and triglyceride metabolism. publishedVersion

Published
2021

342. Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

Author

Hartiala, Jaana A, Han, Yi, Jia, Qiong, Hilser, James R, Huang, Pin, Gukasyan, Janet, Schwartzman, William S, Cai, Zhiheng, Biswas, Subarna, Trégouët, David-Alexandre, Smith, Nicholas L, INVENT Consortium, CHARGE Consortium Hemostasis Working Group, GENIUS-CHD Consortium, Seldin, Marcus, Pan, Calvin, Mehrabian, Margarete, Lusis, Aldons J, Bazeley, Peter, Sun, Yan V, Liu, Chang, Quyyumi, Arshed A, Scholz, Markus, Thiery, Joachim, Delgado, Graciela E, Kleber, Marcus E, März, Winfried, Howe, Laurence J, Asselbergs, Folkert W, van Vugt, Marion, Vlachojannis, Georgios J, Patel, Riyaz S, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Tuomo VM, Kuukasjärvi, Pekka, Laurikka, Jari O, Chang, Xuling, Heng, Chew-Kiat, Jiang, Rong, Kraus, William E, Hauser, Elizabeth R, Ferguson, Jane F, Reilly, Muredach P, Ito, Kaoru, Koyama, Satoshi, Kamatani, Yoichiro, Komuro, Issei, Biobank Japan, Stolze, Lindsey K, Romanoski, Casey E, Khan, Mohammad Daud, Turner, Adam W, Miller, Clint L, Aherrahrou, Redouane, Civelek, Mete, Ma, Lijiang, Björkegren, Johan LM, Kumar, S Ram, Tang, WH Wilson, Hazen, Stanley L, and Allayee, Hooman

Subjects
Genome-wide association study, Aging, Genetic factors, SLC44A3, Clinical Sciences, Myocardial Infarction, INVENT Consortium, Coronary Artery Disease, Cardiorespiratory Medicine and Haematology, Cardiovascular, Japan, Risk Factors, Clinical Research, Genetics, Humans, 2.1 Biological and endogenous factors, Genetic Predisposition to Disease, CHARGE Consortium Hemostasis Working Group, Polymorphism, Aetiology, Heart Disease - Coronary Heart Disease, Human Genome, Endothelial Cells, Single Nucleotide, Atherosclerosis, Biobank Japan, Meta-analysis, Heart Disease, GENIUS-CHD Consortium, Cardiovascular System & Hematology
Abstract

AimsWhile most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atherosclerosis may be distinct from those that predispose to vulnerable plaques and thrombus formation.Methods and resultsWe carried out a genome-wide association study for MI in the UK Biobank (n∼472000), followed by a meta-analysis with summary statistics from the CARDIoGRAMplusC4D Consortium (n∼167000). Multiple independent replication analyses and functional approaches were used to prioritize loci and evaluate positional candidate genes. Eight novel regions were identified for MI at the genome wide significance level, of which effect sizes at six loci were more robust for MI than for CAD without the presence of MI. Confirmatory evidence for association of a locus on chromosome 1p21.3 harbouring choline-like transporter 3 (SLC44A3) with MI in the context of CAD, but not with coronary atherosclerosis itself, was obtained in Biobank Japan (n∼165000) and 16 independent angiography-based cohorts (n∼27000). Follow-up analyses did not reveal association of the SLC44A3 locus with CAD risk factors, biomarkers of coagulation, other thrombotic diseases, or plasma levels of a broad array of metabolites, including choline, trimethylamine N-oxide, and betaine. However, aortic expression of SLC44A3 was increased in carriers of the MI risk allele at chromosome 1p21.3, increased in ischaemic (vs. non-diseased) coronary arteries, up-regulated in human aortic endothelial cells treated with interleukin-1β (vs. vehicle), and associated with smooth muscle cell migration in vitro.ConclusionsA large-scale analysis comprising ∼831000 subjects revealed novel genetic determinants of MI and implicated SLC44A3 in the pathophysiology of vulnerable plaques.

Published
2021

343. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author

Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., and Qi, Lu

Published
2014
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344. Genome-wide association study of sleep duration in the Finnish population

Author

OLLILA, HANNA M., KETTUNEN, JOHANNES, PIETILÄINEN, OLLI, AHO, VILMA, SILANDER, KAISA, KRONHOLM, ERKKI, PEROLA, MARKUS, LAHTI, JARI, RÄIKKÖNEN, KATRI, WIDEN, ELISABETH, PALOTIE, AARNO, ERIKSSON, JOHAN G., PARTONEN, TIMO, KAPRIO, JAAKKO, SALOMAA, VEIKKO, RAITAKARI, OLLI, LEHTIMÄKI, TERHO, SALLINEN, MIKAEL, HÄRMÄ, MIKKO, PORKKA-HEISKANEN, TARJA, and PAUNIO, TIINA

Published
2014
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345. Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits

Author

Herder, Christian, Nuotio, Marja-Liisa, Shah, Sonia, Blankenberg, Stefan, Brunner, Eric J., Carstensen, Maren, Gieger, Christian, Grallert, Harald, Jula, Antti, Kähönen, Mika, Kettunen, Johannes, Kivimäki, Mika, Koenig, Wolfgang, Kristiansson, Kati, Langenberg, Claudia, Lehtimäki, Terho, Luotola, Kari, Marzi, Carola, Müller, Christian, Peters, Annette, Prokisch, Holger, Raitakari, Olli, Rathmann, Wolfgang, Roden, Michael, Salmi, Marko, Schramm, Katharina, Swerdlow, Daniel, Tabak, Adam G., Thorand, Barbara, Wareham, Nick, Wild, Philipp S., Zeller, Tanja, Hingorani, Aroon D., Witte, Daniel R., Kumari, Meena, Perola, Markus, and Salomaa, Veikko

Published
2014
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349. RSPO3 is important for trabecular bone and fracture risk in mice and humans

Author

Nilsson, Karin H., primary, Henning, Petra, additional, El Shahawy, Maha, additional, Nethander, Maria, additional, Andersen, Thomas Levin, additional, Ejersted, Charlotte, additional, Wu, Jianyao, additional, Gustafsson, Karin L., additional, Koskela, Antti, additional, Tuukkanen, Juha, additional, Souza, Pedro P. C., additional, Tuckermann, Jan, additional, Lorentzon, Mattias, additional, Ruud, Linda Engström, additional, Lehtimäki, Terho, additional, Tobias, Jon H., additional, Zhou, Sirui, additional, Lerner, Ulf H., additional, Richards, J. Brent, additional, Movérare-Skrtic, Sofia, additional, and Ohlsson, Claes, additional

Published
2021
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350. DNA methylation signature of chronic low-grade inflammation and its role in cardio-respiratory diseases

Author

Wielscher, Matthias, primary, Mandaviya, Pooja, additional, Kuehnel, Brigitte, additional, Joehanes, Roby, additional, Mustafa, Rima, additional, Robinson, Oliver, additional, Zhang, Tao, additional, Bodinier, Barbara, additional, Walton, Esther, additional, Mishra, Pashupati, additional, Schlosser, Pascal, additional, Wilson, Rory, additional, Tsai, Pei-Chien, additional, Palaniswamy, Saranya, additional, Marioni, Riccardo, additional, Fiorito, Giovanni, additional, Cugliari, Giovanni, additional, Karhunen, Ville, additional, Ghanbari, Mohsen, additional, Psaty, Bruce, additional, Loh, Marie, additional, Bis, Joshua, additional, Lehne, Benjamin, additional, Sotoodehnia, Nona, additional, Deary, Ian, additional, Chadeau-Hyam, Marc, additional, Brody, Jennifer, additional, Cardona, Alexia, additional, Selvin, Elizabeth, additional, Smith, Alicia, additional, Miller, Andrew, additional, Torres, Mylin, additional, Marouli, Eirini, additional, Gào, Xīn, additional, Meurs, Joyce van, additional, Graf-Schindler, Johanna, additional, Rathmann, Wolfgang, additional, Koenig, Wolfgang, additional, Peters, Annette, additional, Weninger, Wolfgang, additional, Farlik, Matthias, additional, Zhang, Yan, additional, Chen, Wei, additional, Xia, Yujing, additional, Teumer, Alexander, additional, Nauck, Matthias, additional, Grabe, Hans, additional, Dörr, Marcus, additional, Lehtimäki, Terho, additional, Guan, Weihua, additional, Milani, Lili, additional, Tanaka, Toshiko, additional, Fischer, Krista, additional, Waite, Lindsay, additional, Kasela, Silva, additional, Vineis, Paolo, additional, Verweij, Niek, additional, Harst, Pim van der, additional, Iacoviello, Licia, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Tzala, Evangelia, additional, Matullo, Giuseppe, additional, Hurme, Mikko, additional, Raitakari, Olli, additional, Colicino, Elena, additional, Baccarelli, Andrea, additional, Kähönen, Mika, additional, Herzig, Karl-Heinz, additional, Li, Shengxu, additional, Heijmans, Bastiaan, additional, Conneely, Karen, additional, Kooner, Jaspal, additional, Kottgen, Anna, additional, Deloukas, Panos, additional, Relton, Caroline, additional, Ong, Ken, additional, Bell, Jordana, additional, Boerwinkle, Eric, additional, Elliott, Paul, additional, Brenner, Hermann, additional, Beekman, Marian, additional, Levy, Daniel, additional, Waldenberger, Melanie, additional, Chambers, John, additional, Dehghan, Abbas, additional, and Jarvelin, Marjo-Riitta, additional

Published
2021
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