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301. El Consejo Nacional de Higiene y la consolidación de una elite profesional al servicio del Estado. Argentina, 1880-1900

Author

Ricardo González Leandri

Subjects
argentina, siglo xix, médicos, profesionales, intelectuales, higiene, salud pública, epidemias, estado, Latin America. Spanish America, F1201-3799
Abstract

Este artículo analiza aspectos del proceso de consolidación de una intelligentzia médica en Argentina en los últimos veinte años del siglo XIX. Trata, sobre todo, de su vínculo con el Estado a través del Consejo de Higiene, institución encargada de fijar la política sanitaria del periodo. Gracias a la creciente influencia de estos médicos, paradójicamente más cercanos al gobierno a la vez que más autónomos, el Consejo adquirió durante el periodo reseñado un conjunto de nuevas atribuciones a nivel nacional, a la vez que consiguió prestar mayor atención a la llamada sanidad interna.

Published
2004
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302. Reseñas bibliográficas

Author

Miranda Lida, Pedro Pérez Herrero, Agustina Prieto, Daniel Lvovich, Carmen Castañeda, Alfredo Moreno Cebrián, Mª del Carmen Borrego Plá, Charles F. Walker, Gisela Cánepa, Izaskun Álvarez Cuartero, Juan Suriano, Ricardo González Leandri, and Gabriella Chiaramonti

Subjects
Latin America. Spanish America, F1201-3799
Published
2004

308. Clinical impact of routine CT esophagogram after peroral endoscopic myotomy (POEM) for esophageal motility disorders

Author

Chartier, Marion, additional, Barat, Maxime, additional, Dohan, Anthony, additional, Belle, Arthur, additional, Oudjit, Ammar, additional, Abou Ali, Einas, additional, Hallit, Rachel, additional, Leandri, Chloé, additional, Scialom, Sophie, additional, Coriat, Romain, additional, Chaussade, Stanislas, additional, Soyer, Philippe, additional, and Barret, Maximilien, additional

Published
2021
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309. Reseñas bibliográficas

Author

Mariano Plotkin, María Asunción Merino Hernando, Fernando Gómez, Zoila S. Mendoza, Mª Justina Sarabia Viejo, Agustina Prieto, Manuela Cristina García Bernal, Pablo E. Pérez-Mallaína Bueno, Ludolfo Paramio, Sergio Eduardo Visacovsky, Ángela Carballeda, and Ricardo González Leandri

Subjects
Latin America. Spanish America, F1201-3799
Published
2003

310. Field validation of recycled cold mixes viscoelastic properties

Author

Leandri, Pietro, Losa, Massimo, and Di Natale, Andrea

Subjects
Asphalt -- Properties -- Analysis, Bituminous materials -- Analysis -- Properties, Business, Construction and materials industries
Abstract

ABSTRACT Visco-elastic properties of recycled cold mixes are analyzed in this paper by tests carried out in laboratory; the aim of the paper is to evaluate how reliable are these [...]

Published
2015
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311. STABILOMETRIC ASSESMENT OF POSTURAL CHANGES INDUCED BY SPINE ORTHOSES IN A GERIATRIC POPULATION

Author

C. Seriolo, Andrea Casabella, A. Palermo, Massaro W, Luigi Molfetta, and M Leandri

Subjects
Spine (zoology), medicine.medical_specialty, Physical medicine and rehabilitation, Geriatric population, business.industry, Osteoporosis, Medicine, business, medicine.disease
Abstract

https://www.worldwidejournals.com/international-journal-of-scientific-research-(IJSR)/recent_issues_pdf/2019/November/stabilometric-assesment-of-postural-changes-induced-by-spine-orthoses-in-a-geriatric-population_November_2019_1572614323_9321872.pdf

Published
2019

312. Le syndrome de motricité œsophagienne inefficace

Author

Chloé Leandri, Mahaut Leconte, Romain Coriat, Anthony Dohan, Maximilien Barret, Stanislas Chaussade, and Marie-Anne Guillaumot

Subjects
medicine.medical_specialty, medicine.drug_class, business.industry, digestive, oral, and skin physiology, Reflux, Proton-pump inhibitor, General Medicine, medicine.disease, Gastroenterology, Dysphagia, digestive system diseases, Scleroderma, Pharmacological treatment, 03 medical and health sciences, 0302 clinical medicine, Esophageal motility disorder, 030220 oncology & carcinogenesis, Internal medicine, medicine, Esophageal sphincter, 030211 gastroenterology & hepatology, In patient, medicine.symptom, business
Abstract

Ineffective esophageal motility is the most frequent esophageal motility disorder. It is currently defined by 50% or more ineffective esophageal contractions and a normal lower esophageal sphincter relaxation on high-resolution esophageal manometry. Although reported in patients without symptoms, it is typically associated with gastro-esophageal reflux disease, and might be a consequence of the reflux. Ineffective esophageal motility can account for a certain degree of dysphagia, and is associated with a more severe gastroesophageal reflux. Todate, no specific endoscopic or pharmacologic treatment is available, and proton pump inhibitor are advisable when gastro-esophageal reflux is associated.

Published
2019

313. Association between progesterone to number of mature oocytes index and live birth in GnRH antagonist protocols

Author

Florence Lesourd, Jean Parinaud, Roger Leandri, Clémentine Cohade, Lise Branet, Jessika Moreau, Cynthia Simon, N. Gatimel, CHU Toulouse [Toulouse], Groupe de recherche en fertilité humaine ( GRFH), Université Toulouse III - Paul Sabatier (UT3), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées

Subjects
Adult, Male, 0301 basic medicine, Pregnancy Rate, [SDV]Life Sciences [q-bio], medicine.medical_treatment, media_common.quotation_subject, Stimulation, Fertilization in Vitro, Negative association, Chorionic Gonadotropin, Intracytoplasmic sperm injection, Gonadotropin-Releasing Hormone, Andrology, 03 medical and health sciences, Hormone Antagonists, 0302 clinical medicine, Ovulation Induction, Pregnancy, medicine, Humans, Sperm Injections, Intracytoplasmic, Birth Rate, Ovarian Reserve, Ovulation, Infertility, Male, Progesterone, Ivf outcome, Retrospective Studies, media_common, 030219 obstetrics & reproductive medicine, business.industry, GnRH Antagonist, Pregnancy Outcome, Obstetrics and Gynecology, Embryo, Embryo Transfer, 030104 developmental biology, Reproductive Medicine, Oocytes, Female, Follicle Stimulating Hormone, Live birth, business, Infertility, Female, Live Birth, Developmental Biology
Abstract

What is the association between blood progesterone level alone, progesterone to mature oocytes index (PMOI) and IVF outcomes?Clinical data from 960 couples undergoing their first fresh embryo transfer after an intracytoplasmic sperm injection attempt carried out between September 2012 and July 2017 were analysed. All patients underwent ovarian stimulation combining recombinant FSH and gonadotrophin releasing hormone antagonist. Progesterone was measured on the day on which ovulation was triggered. The PMOI was divided into four groups based on 25th, 50th and 75th percentiles, and live birth and implantation rates were compared between the groups.A negative association was found between PMOI levels, live birth and implantation rates. When adjusting for age, ovarian stimulation index (OSI) and number of embryos transferred, the PMOI remained negatively correlated to live birth rate (LBR) (OR = 0.147 [0.031 to 0.701]; P = 0.0161), whereas total blood progesterone was no longer evident. Moreover, the LBR (18.5% versus 28.4%; P0.01) and implantation rate (12.4% versus 21.0%; P0.01) were significantly decreased only when PMOI was 0.167 ng/ml or greater, irrespective of progesterone concentration (or ≥1.08 ng/ml). The opposite was not true, however. Similar PMOIs were recorded in the same patient from one attempt to the next, and were partially linked to basal FSH, anti-Müllerian hormone, antral follicle count and OSI.PMOI seems to be more predictive than total progesterone level of IVF outcome and reflects the ability of embryos to develop as it is linked to the implantation rate.

Published
2019

314. Patients' and physicians' interpretation of chemotherapy-induced peripheral neurotoxicity

Author

Cavaletti, G., Cornblath, D. R., Merkies, I. S. J., Postma, T. J., Rossi, E., Alberti, Paola, Bruna, J., Argyriou, A. A., Briani, C., Velasco, Riccardo, Kalofonos, H. P., Psimaras, D., Ricard, D., Pace, A., Faber, C. G., Lalisang, R. I., Brandsma, D., Koeppen, S., Kerrigan, S., Schenone, A., Grisold, W., Mazzeo, A., Padua, L., Dorsey, S. G., Penas-Prado, M., Valsecchi, M. G., Frigeni, B., Lanzani, F., Mattavelli, L., Piatti, M. L., Binda, D., Bidoli, P., Cazzaniga, M., Cortinovis, D., Galie, E., Campagnolo, M., Salvalaggio, A., Ruiz, M., Vanhoutte, E. K., Boogerd, W., Hense, J., Grant, R., Storey, D., Reni, L., Demichelis, C., Pessino, A., Granata, G., Leandri, Martina, Ghigliotti, I., Plasmati, R., Pastorelli, Federica, Heimans, J. J., Eurelings, M., Meijer, R. J., Pozza, E. L., Toscano, A., Gentile, L., Santarpia, M., Gonzalez, C. D., Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Interne Geneeskunde, MUMC+: MA Medische Oncologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, MUMC+: DA KG Polikliniek (9), Cavaletti, G, Cornblath, D, Merkies, I, Postma, T, Rossi, E, Alberti, P, Bruna, J, Argyriou, A, Briani, C, Velasco, R, Kalofonos, H, Psimaras, D, Ricard, D, Pace, A, Faber, C, Lalisang, R, Brandsma, D, Koeppen, S, Kerrigan, S, Schenone, A, Grisold, W, Mazzeo, A, Padua, L, Dorsey, S, Penas-Prado, M, Valsecchi, M, Bidoli, P, Cazzaniga, M, Neurology, and CCA - Cancer Treatment and quality of life

Subjects
Adult, medicine.medical_specialty, Activities of daily living, side effect, media_common.quotation_subject, medicine.medical_treatment, assessment, chemotherapy, neurotoxicity, patient reported outcome measures, side effects, Medizin, NEUROPATHY CIPN, Neurological examination, Severity of Illness Index, 03 medical and health sciences, Vibration perception, 0302 clinical medicine, Perception, Internal medicine, Activities of Daily Living, medicine, Humans, VALIDITY, media_common, Oncologists, Neuroscience (all), Neurology (clinical), Chemotherapy, medicine.diagnostic_test, business.industry, General Neuroscience, Neurotoxicity, Outcome measures, Peripheral Nervous System Diseases, assessment, chemotherapy, neurotoxicity, patient reported outcome measures, side effects, Adult, Humans, Neurotoxicity Syndromes, Peripheral Nervous System Diseases, Activities of Daily Living, Oncologists, Patient Reported Outcome Measures, Severity of Illness Index, OUTCOME MEASURES, medicine.disease, Peripheral, patient reported outcome measure, 030220 oncology & carcinogenesis, Neurotoxicity Syndromes, business, 030217 neurology & neurosurgery
Abstract

To test if and how chemotherapy-induced peripheral neurotoxicity (CIPN) is perceived differently by patients and physicians, making assessment and interpretation challenging. We performed a secondary analysis of the CI-PeriNomS study which included 281 patients with stable CIPN. We tested: (a) the association between patients' perception of activity limitation in performing eight common tasks and neurological impairment and (b) how the responses to questions related to these daily activities are interpreted by the treating oncologist. To achieve this, we compared patients' perception of their activity limitation with neurological assessment and the oncologists' blind interpretation. Distribution of the scores attributed by oncologists to each daily life maximum limitation ("impossible") generated three groups: Group 1 included limitations oncologists attributed mainly to motor impairment; Group 2 ones mainly attributed to sensory impairment and Group 3 ones with uncertain motor and sensory impairment. Only a subset of questions showed a significant trend between severity in subjective limitation, reported by patients, and neurological impairment. In Group 1, neurological examination confirmed motor impairment in only 51%-65% of patients; 76%-78% of them also had vibration perception impairment. In Group 2, sensory impairment ranged from 84% to 100%; some degree of motor impairment occurred in 43%-56% of them. In Group 3 strength reduction was observed in 49%-50% and sensory perception was altered in up to 82%. Interpretation provided by the panel of experienced oncologists was inconsistent with the neurological impairment. These observations highlight the need of a core set of outcome measures for future CIPN trials.

Published
2019

315. Coumarin as a Quantitative Probe for Hydroxyl Radical Formation in Heterogeneous Photocatalysis

Author

Mats Jonsson, Valentina Leandri, and James M. Gardner

Subjects
macromolecular substances, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, Photochemistry, Coumarin, 01 natural sciences, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry.chemical_compound, General Energy, chemistry, Photocatalysis, heterocyclic compounds, Hydroxyl radical, Physical and Theoretical Chemistry, 0210 nano-technology
Abstract

In this work, we have assessed coumarin as a quantitative probe for hydroxyl radical formation in heterogeneous photocatalysis. Upon reaction with the hydroxyl radical, coumarin produces several hy ...

Published
2019

316. Comparison of extraction techniques for polycyclic aromatic hydrocarbons from lichen biomonitors

Author

Patricia B.C. Forbes and Leandri van der Wat

Subjects
chemistry.chemical_classification, Peak area, Lichens, Chemistry, Health, Toxicology and Mutagenesis, Extraction (chemistry), Analytic Sample Preparation Methods, Polycyclic aromatic hydrocarbon, General Medicine, 010501 environmental sciences, Quechers, 01 natural sciences, Pollution, Acetone, Hexane, chemistry.chemical_compound, Environmental chemistry, Hexanes, Environmental Chemistry, Sample preparation, Polycyclic Aromatic Hydrocarbons, Microwaves, Lichen, 0105 earth and related environmental sciences
Abstract

Lichens are useful biomonitors for atmospheric polycyclic aromatic hydrocarbons (PAHs). Different sample preparation techniques were explored in this regard, including ultrasound-assisted solvent extraction, microwave-assisted extraction, Soxhlet, and the quick, easy, cheap, effective, rugged, and safe (QuEChERS) technique. It was found that a QuEChERS technique using hexane:acetone (1:1, v/v), never reported before for application to lichens, provided the best recoveries of internal standards, the highest total peak area for all PAHs of interest, and %RSDs comparable with the other preparation techniques tested. The optimized sample preparation technique was found to be a comparatively fast method (45 min), with good recoveries (96%), using less solvents and minimal energy consumption. Strong matrix effects were found: both strong enhancement (for the lighter PAHs) and strong suppression (for the heavier PAHs). The use of matrix-matched standards is thus imperative for the accurate determination of PAH concentrations in the lichen samples. Graphical abstract "Note: This data is mandatory. Please provide."

Published
2019

317. Expression of phospholipase <scp>PLC</scp> Zeta in human spermatozoa: impact of cryopreservation

Author

S. Fargeon, Jean Parinaud, Roger Leandri, Jessika Moreau, and N. Gatimel

Subjects
Cryopreservation, Male, Infertility, 030219 obstetrics & reproductive medicine, Phospholipase C, Chemistry, Urology, Endocrinology, Diabetes and Metabolism, Significant difference, Oocyte activation, Phospholipase, medicine.disease, Spermatozoa, Andrology, 03 medical and health sciences, Phosphoinositide Phospholipase C, 0302 clinical medicine, Endocrinology, Reproductive Medicine, medicine, Hum, Humans, Semen Preservation
Abstract

BACKGROUND Cryopreservation is used for infertility treatment and for fertility preservation. The results of the use of frozen spermatozoa for ART (Assisted Reproductive Technology) are lower than those of fresh spermatozoa. The phospholipase C Zeta (PLCζ) protein is involved in oocyte activation. OBJECTIVES The aim of this study was to compare the percentage of spermatozoa expressing phospholipase C Zeta protein before and after a frozen-thawing cycle. MATERIALS AND METHODS Samples were provided after at least 2 days of sexual abstinence. A part of the fresh ejaculate (200 μL) was recovered for the study. Fifty microliters was necessary to carry out the technique before freezing. The remaining 150 μl was frozen according to a slow manual freezing technique. The samples were treated based on the procedure described by Yelumalai et al. (Fertil. Steril., 104, 2015, 561-568.e4) and Grasa et al. (Hum. Reprod. Oxf. Engl. 23, 2008, 2513-2522). RESULTS Freezing was associated with a decrease in the percentage of spermatozoa exhibiting PLCζ (44 ± 22% before vs 31 ± 19% after, p

Published
2019

318. Light-induced electrolyte improvement in cobalt tris(bipyridine)-mediated dye-sensitized solar cells

Author

István Furó, Valentina Leandri, Jiajia Gao, Ahmed M. El-Zohry, Yuan Fang, Govind Kumar Prajapati, Torben Lund, Jing Dai, Yan Hao, Wenxing Yang, Per H. Svensson, Gerrit Boschloo, and Lars Kloo

Subjects
Photo-voltage, chemistry.chemical_element, 02 engineering and technology, Electrolyte, Conductivity, Dye-sensitized solar cells, Photochemistry, Electrochemistry, Redox, Electrolytes, Bipyridine, chemistry.chemical_compound, Charge transfer, Redox systems, Naturvetenskap, General Materials Science, Redox reactions, Electrode/electrolyte interfaces, Light effects, Photocurrent, Photoelectrochemical system, Spectroscopic investigations, Economic and social effects, Renewable Energy, Sustainability and the Environment, Light exposure, Cobalt, General Chemistry, 021001 nanoscience & nanotechnology, Control experiments, Dye-sensitized solar cell, chemistry, Natural Sciences, 0210 nano-technology
Abstract

Lithium-ion-free tris(2,2′-bipyridine) Co(ii/iii)-mediated electrolytes have previously been proposed for long-term stable dye-sensitized solar cells (DSSCs). Such redox systems also offer an impressive DSSC performance improvement under light soaking exposure, manifested by an increase in photocurrent and fill factor without the expense of decreasing photovoltage. Kinetic studies show that charge transfer and ion diffusion at the electrode/electrolyte interface are improved due to the light exposure. Control experiments reveal that the light effect is unambiguously associated with electrolyte components, [Co(bpy)3]3+ and the Lewis-base additive tert-butylpyridine (TBP). Electrochemical and spectroscopic investigation of the [Co(bpy)3]3+/TBP mixtures points out that the presence of TBP, which retards the electrolyte diffusion, however causes an irreversible redox reaction of [Co(bpy)3]3+ upon light exposure that improves the overall conductivity. This discovery not only provides a new strategy to mitigate the typical Jsc-Voc trade-off in Co(ii/iii)-mediated DSSCs but also highlights the importance of investigating the photochemistry of a photoelectrochemical system. Funding details: China Scholarship Council, CSC; Funding details: Energimyndigheten; Funding details: Vetenskapsrådet, VR; Funding text 1: We gratefully acknowledge the Swedish Research Council, the Swedish Energy Agency as well as the China Scholarship Council (CSC) for nancial support. The authors also thank Dr Lei Wang for his helpful assistance in 1H-NMR spectroscopic studies.

Published
2019

320. Anti-sperm antibodies detection by a modified MAR test: Towards a better definition of its indications

Author

François Isus, Jean Parinaud, Jessika Moreau, Nathalie Moinard, Roger Leandri, and Nicolas Gatimel

Subjects
Male, Infertility, medicine.medical_specialty, media_common.quotation_subject, medicine.medical_treatment, Fertility, 03 medical and health sciences, 0302 clinical medicine, Mixed antiglobulin reaction, medicine, Humans, Infertility, Male, Autoantibodies, media_common, Gynecology, 030219 obstetrics & reproductive medicine, Assisted reproductive technology, biology, business.industry, Obstetrics and Gynecology, Sperm Agglutination, medicine.disease, Spermatozoa, Sperm, Test (assessment), Semen Analysis, Reproductive Medicine, 030220 oncology & carcinogenesis, biology.protein, Antibody, business, Developmental Biology
Abstract

Anti-sperm antibodies (ASA) have been shown to reduce male fertility but consensus about the precise situations in which tests should be carried out are lacking. In infertility investigations, should the mixed antiglobulin reaction (MAR) test be a first-line test? Should it be carried out systematically before assisted reproductive technology (ART)? What are the risk factors for ASA?All infertile patients (n = 1364) were tested with SpermMar (modified MAR test) between July 2013 and June 2017. Intra-patient variability of the MAR test was also assesed by comparing two tests within the same year in selected patients (n = 101).The main factor that influenced the percentage of ASA was the presence or absence of sperm agglutination. In the presence of agglutinations, 27 out of 72 (37.5%) patients were positive for ASA compared with 33 out of 1292 (2.6%) in the absence of agglutinations (P0.0001). When one risk factor was present (spontaneous sperm agglutination, history of scrotal trauma or inguinal surgery), 33 out of 179 (18.44%) tests were positive for ASA (≥50% coated spermatozoa), whereas only 27 out of 1242 (2.2%) were positive when no risk factor was present (P0.0001).ASA detection should not be systematically recommended in investigations of fertility status and before ART but reserved for when sperm agglutination is found during conventional sperm examination, or if the patient has a history of scrotal trauma or has undergone inguinal surgery.

Published
2018

321. La elite profesional docente como fracción intelectual subordinada. Argentina: 1852-1900

Author

Ricardo González Leandri

Subjects
Latin America. Spanish America, F1201-3799
Abstract

La centralización y el impulso a la “educación patriótica”, diseñados para lograr una rápida homogeneidad cultural entre la población fueron las características clave del sistema público de educación elemental que se consolidó en Argentina en la segunda mitad del siglo XIX. Ellas auparon hacia su cúspide a un sector de funcionarios “normalistas” que tendieron a considerarse como una elite intelectual más apegada a los destinos del Estado que a los de la profesión de la que formaban parte. Sin embargo, en contra de sus expectativas, no pudieron dejar de ser un grupo intelectual subordinado. Los motivos deben buscarse en el monopolio que los “doctores”, pertenecientes en general a los sectores sociales más encumbrados, ejercieron sobre los espacios en los que se definían las abstracciones académicas y las políticas educativas y en las estrategias de distinción que los propios “normalistas” aplicaron sobre los demás docentes, que los debilitó como sector profesional.

Published
2001
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325. Soluble HLA-G in IVF/ICSI embryo culture supernatants does not always predict implantation success: a multicentre study

Author

Tabiasco, Julie, d'Hauterive, Sophie Perrier, Thonon, Fabienne, Parinaud, Jean, Léandri, Roger, Foidart, Jean-Michel, Chaouat, Gérard, Munaut, Carine, Lombroso, Raoul, Selva, Jacqueline, Bergère, Marianne, Hammoud, Ibrahim, Kozma, Noemi, Aguerre-Girr, Maryse, Swales, Anna KE, Sargent, Ian L, Le Bouteiller, Philippe, and Lédée, Nathalie

Published
2009
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326. Diagnósticos de la heterogeneidad social en América Latina.

Author

Leandri, Ricardo Gonzalez and Pagnotta, Chiara

Abstract

An introduction is presented in which editor discusses various articles within the issues on topics including rhetoric about the natural heterogeneity of Latin America; educational system to address the disability and campaigns organized by the Argentine army oriented to adult education.

Published
2023

327. Economically advantageous pathways for reducing greenhouse gas emissions from industrial hydrogen under common, current economic conditions

Author

David Zheng, Michael R. Hoffmann, Neil A. Fromer, Hugo F. Leandri, Evody Tshijik Karumb, and Cody E. Finke

Subjects
Waste management, Hydrogen, Electrolysis of water, Renewable Energy, Sustainability and the Environment, Commodity chemicals, business.industry, Fossil fuel, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Pollution, 0104 chemical sciences, chemistry.chemical_compound, Nuclear Energy and Engineering, chemistry, Greenhouse gas, Carbon dioxide, Environmental Chemistry, Capital cost, Environmental science, 0210 nano-technology, business, Hydrogen production
Abstract

Hydrogen is a major industrial chemical whose manufacture is responsible for ∼3% of global carbon dioxide emissions. >95% of hydrogen is made via reforming fossil fuels which typically co-produces hydrogen and waste carbon dioxide. Nearly all other hydrogen is co-produced with other commodity chemicals. Unfortunately, many alternative, clean hydrogen production processes are small-scale because they require major reductions in capital cost or energy prices to be economical enough for industry. Because the climate problem is urgent, and the economics of future energy is uncertain, this paper seeks to expand the options for producing industrial-scale, clean hydrogen under common, present-day economic conditions. First, we build a model to understand the economic and carbon dioxide emissions constraints of sulfur electrolysis which is an emerging process that cogenerates hydrogen and co-salable sulfuric acid and has the potential to produce up to 36% of the world's current hydrogen demand under present-day, average US economic conditions. We also use our model to evaluate water electrolysis, which cogenerates hydrogen and waste oxygen, but is not economical under present-day average US economic conditions. We then propose criteria for identifying clean hydrogen production chemistries. Using these criteria, we find enough reactions to have the combined potential to make over 150% of the world's industrial hydrogen needs under present-day, average US economic conditions while reducing cost and reducing or eliminating CO2 emissions. Given the urgency of the climate problem, we believe that an economic analysis, such as this is crucial to near-term CO2 emissions reductions.

Published
2021

328. Chert procurement in Corsica during the Neolithic: Inferring social territories in the Tyrrhenian islands

Author

Paul Fernandes and Céline Leandri

Subjects
Provenance, geography, geography.geographical_feature_category, Procurement, Peninsula, Facies, Context (language use), Structural basin, Archaeology, Chronology
Abstract

From the Neolithic, foreign siliceous materials were imported into Corsica as the island lacks local chert and obsidian. Such a context constitutes a real opportunity to investigate the relationship of the island with surrounding areas, in perspective with cultural evolutions. For 20 years, chert sourcing studies were carried out. We took into account 26 sites, dating from the Ancient Neolithic to the Final Neolithic. The work is based on non-destructive petro-archaeological observations of the artefacts. and on the survey and characterization of Sardinian sources (320 samples collected and 60 different lithotypes characterized). The study aims to better understand the place of chert among the lithic assemblages throughout time and identify the provenance of most of the chert material introduced into Corsica. It reveals procurement evolution in terms of preferred facies and of stages of introduction, depending on the chronology and geographical situation of the sites. The results confirm connections with Sardinia, among which Perfugas basin constitutes a major source of raw material for Corsica. It also shows relations with the Italian Peninsula for some Middle Neolithic sites in Northern Corsica. Comparisons with data from Sardinia show the affinities and differences between the two islands and open further avenues for research.

Published
2021

329. Recent Advances in Membrane-Based Electrochemical Hydrogen Separation: A Review

Author

Dmitri Bessarabov, Hein W.J.P. Neomagus, and Leandri Vermaak

Subjects
Hydrogen, Computer science, Emerging technologies, 020209 energy, Separation (aeronautics), hydrogen purification/separation, chemistry.chemical_element, Filtration and Separation, 02 engineering and technology, Review, lcsh:Chemical technology, electrochemical hydrogen separation, 0202 electrical engineering, electronic engineering, information engineering, Chemical Engineering (miscellaneous), lcsh:TP1-1185, proton exchange membrane (PEM), lcsh:Chemical engineering, proton exchange membrane (PEM), hydrogen purification/separation, Process Chemistry and Technology, lcsh:TP155-156, Separation technology, 021001 nanoscience & nanotechnology, chemistry, electrochemical hydrogen pump, Biochemical engineering, 0210 nano-technology
Abstract

In this paper an overview of commercial hydrogen separation technologies is given. These technologies are discussed and compared—with a detailed discussion on membrane-based technologies. An emerging and promising novel hydrogen separation technology, namely, electrochemical hydrogen separation (EHS) is reviewed in detail. EHS has many advantages over conventional separation systems (e.g., it is not energy intensive, it is environmentally-friendly with near-zero pollutants, it is known for its silent operation, and, the greatest advantage, simultaneous compression and purification can be achieved in a one-step operation). Therefore, the focus of this review is to survey open literature and research conducted to date on EHS. Current technological advances in the field of EHS that have been made are highlighted. In the conclusion, literature gaps and aspects of electrochemical hydrogen separation, that require further research, are also highlighted. Currently, the cost factor, lack of adequate understanding of the degradation mechanisms related to this technology, and the fact that certain aspects of this technology are as yet unexplored (e.g., simultaneous hydrogen separation and compression) all hinder its widespread application. In future research, some attention could be given to the aforementioned factors and emerging technologies, such as ceramic proton conductors and solid acids.

Published
2021

331. Miradas médicas sobre la cuestión social. Buenos aires a fines del siglo XIX y principios del XX

Author

Ricardo González Leandri

Subjects
argentina, médicos, «cuestión social», profesiones, estado, intelectuales, Latin America. Spanish America, F1201-3799
Abstract

El presente artículo destaca el papel jugado por el proceso de profesionalización médico en el surgimiento y desarrollo de la «Cuestión Social» en Argentina a fines del siglo XIX y principios del XX. Con tal objetivo presta especial atención a la compleja y estrecha trama institucional, corporativa e intelectual establecida para esas fechas entre los médicos y el Estado.

Published
2000
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337. Detecting stratigraphical issues using direct radiocarbon dating from small‐mammal remains

Author

Rofes, Juan, primary, Cersoy, Sophie, additional, Zazzo, Antoine, additional, Royer, Aurelien, additional, Nicod, Pierre‐Yves, additional, Laroulandie, Veronique, additional, Langlais, Mathieu, additional, Pailler, Yvan, additional, Leandri, Celine, additional, Leandri, Franck, additional, Lebon, Matthieu, additional, and Tresset, Anne, additional

Published
2020
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338. Prevalence of diabetic and impact on cardiovascular events and mortality in patients with chronic coronary syndromes, across multiple geographical regions and ethnicities

Author

H Appeltants, C Boesch, I Cromarty, D Carretta, S Romanov, U Windstetter, F Mibach, Jens Refsgaard, S Lebedev, F Proietti, M Y Tamimi, M C Gamboa, M Novikova, E Prada, K H Sim, E Messas, E Zherlitsyna, A Kalampalikis, N Nevolina, N Trocan, J Cohen, G Szto, R Gilabert Gómez, M Omelchenko, A Pinzani, D Goodwin, J Umaran Sánchez, Kim Fox, S H Dong, K Kronberg, E Castillo Lueña, T Ignatieva, S Joubert, C Macchi, S Lee, S Eidelman, F Alizon, S Chandra, M Akbar, D M Colquhoun, G Yanes Bowden, J de Juan Baguda, M Sebastian, C Wernham, K Miedema, R La Greca, C Morton, B S Jheeta, A C Tran, T Q Do, O Rodrigues, J Yan, S H Kim, R Jurgaitienė, Jean-Claude Tardif, R Baleón, D Hay, V Hennebelle, F Fazekas, R Davies, P Gratia, L Sorodoc, S Y Wu, C Martínez Sánchez, L Lopes Antunes, T H T Pham, I Suliman, M J Gómez Martinez, A Pernat, S H Hur, M Alanazy, L Zhabina, M Stanley, J Rogers, Y J Kim, S Geffroy, L K Andersen, S Coman, V Pedrosa del Moral, Y Garaud, J Krupicka, O Dzhkha, C Paul, M Jeżewska, B Mahler Mioto, V Abduvalieva, P Morra, L Kucheryava, C La Rosa, B Chan, M Wrębiak-Trznadel, A Kozlowski, M Sharif, L López Barreiro, V Kolesnikov, M Lawrence, A Tucker, C Okawabata, B La Hay, E Sadauskienė, B K Nguyen, L Bui, A Said, M E Ruíz Esparza, R K Saran, M S C Ho, E Homs Espinach, J R Romo Santana, J Forte De Carvalho, I Pattison, H H Phan, L Baleeva, L Kisiel, A López Granados, C Raters, F Paganelli, R Haberl, A P T Wong, D Xu, R Jagathesan, L Grekhova, H Stursova, Q B Truong, P Raymond, Y Sosnova, N H Khong, J Zarauza Navarro, C Florescu, L Gorshkova, N Saaidin, E Gordillo Higuero, L Davin, I Budanova, C Lavicka, L Gruznykh, P Bogdański, A Dufka, I Arroja, H A R Tahir, G Wilson, G Kolios, S J Yoon, Simon Cattan, K Berdnik, A Serrano, B Sievers, A Rodríguez Almodóvar, L A Holden, F O'Reilly, D Verleyen, H Hafez, K Nehrig, S M Kang, S Berrisch-Rahmel, E Meyer-Michael, P Samama, L Soares, A K Nguyen, F Tuktarova, C Weytjens, E Sandoval Rodriguez, J Cheng, F M Villasenor, João Morais, B Sullivan, R Zimoląg, Albert V. Smith, S F Ding, J C Louchart, G Guardigli, R Furtak, P Azzolini, S Chushak, J L Delgado Prieto, S Kornienko, K K Sia, J H Shin, F Baylac Domengetroy, P Błaszczak, M Saade, N Černič-Šuligoj, K Coetzee, A Kadleckova, V Scollo, O Larina, R Pal, M M Singh, N Nosova, R Burns, B S Yoo, O Gukov, F Massari, V Antia, A Brattström, G Holt, M Scherbak, V Firastrau, Y J Li, E Mikhailova, L Machado Cesar, C García García, J Pjontek, C Everton Biglow, G Pes, C Brown, A Bumbu, S Felis, R Bosch, M Lazaro, Luigi Tavazzi, R Engel, I Romeo Castillejo, Y S Byun, F Matias, I Grushetskaya, C Mestre-Fernandes, T Kheliya, S Schlesingerova, G Theodorakis, I Tsamopoulos, R Pedretti, A Puente Barragán, M P Vo, B Lammens, T Carruthers, J S Bhatt, A Khodanov, N Pasechnaya, I Petrova, G Boutros, I A Khan, E Le Moal, D Garofalo, H R Malaterre, A Bahal, J F Martínez González, H N Dinh, N V Pham, C Barjhoux, I Gilmour, C Soriano Navarro, O D Chioncel, K Tóth, N Borodina, P Khanoyan, B Sevilla Toral, H H Kim, C M A Bui, C Dernedde, N Eliseeva, M Galinier, E Kosachek, M M Doohan, L Potapska, M Tennekoon, R Nourallah, L Perez De Isla, K H Chee, E Panova, D M Walker, G Glanowska, G Hua, A Silvestre, W Wang, Matthew A. Brown, B Luke, G Jarosiński, R Davis, S Cleron, C Liatas, I Orestis, M Dereń, J Sudnik, S X Zhou, J Fuertes Alonso, O Baranova, S Mingalaeva, T N Vo, K A Ngo, J A Rodríguez Fernández, R Ishmael, G Bode, K K Chan, G Al Radaideh, S Ramphall, H D Theron, V Montagud Saavedra, A Yusuf, G F Mazzanti Mignaqui, L Evtukhova, J Lorenc, D Beacock, O B Šlapikienė, F Alitto, J N Poujois, B Berzal Martín, M Felbermayer, V Mallamaci, T Spitsina, R Ramachandran, A Jánosi, V Dženkevičiūtė, S Gillam, V Joulie, G Esna Ashari, R Henry, E Durand, A Alam, V Fourchard, H Dreycopp, R Fressonnet, C Camossa, O Jerzykowska, M Castrucci, G Sinicropi, B K Goyal, V Vasylenko, R Grogono, M Partington, B Vaquette, R Blindt, Mª T Moreno Casquete, V Kukaleva, W Streb, P F Clavette, M Pérez Paredes, V Hadjiivanov, C Bundy, D E Manyari, A Wassef, J Kuchar, W Nisker, P S Bath, S Panpunnung, G H Choo, Datshana P Naidoo, Y Pavlova, R McManus, N Brand, E Davies, L Prunier, A Schenowitz, P Sternthal, T Sinotova, J Martínez Florez, R Sykulski, J Pinar Sopena, M Balbi, Y Pesant, D A Playford, C Villar Mariscal, F Redding Escalante, W Wongcharoen, O Grechishkina, A Girão, M Speth-Nitschke, K A Mahendran, A Bianco, A Vadavi, G Singh, L Petoin Peuch, L Sukhanova, A Y Y Fong, J L Vega Barbado, A Dzien, S Honorat, G Ansalone, G Kamensky, G McLaren, T B Kim, I Bratu, R Fillet, V Rogozhyna, L Nagy, M Malgina, M A Sheikh Abdul Kader, Z C Li, L Rotaru H Rus, D Adamczyk-Kot, J Estrella, S Serrano García, P Farto E Abreu, D Mescharekova, Su Thillai Vallal, P Seal, S Möller, A Cziráki, T T H Ta, S Davies, H Ge, M Arafah, M Ovize, A Olszewski, V Aboyans, C Roche, F Al Tamimi, L Popova, V Kazachkova, R Rennert, J Aubry, G Bourgeois, J Mackrell, F Al Kandari, N Reifart, J Bérubé, W H J Hutse, O Lysunets, I Butkuvienė, J Cotroneo, J Gdalia, J Dalle Mule, R Santos, B Singh, H Mohammed, A Birkenhagen, T Chiscaneanu, H Sullivan, Jacob A. Udell, N Bolotova, A Jankowska, M Skonieczny, B S K Ch'ng, O Aiyegbayo, S Ciaroni, N Lago, S R Coimbra, R Ellis, B K Koo, S Rostik, P Jacquier, A Conradie, N Biryukova, M Ayche, A Khripun, B Peperstraete, E Velasco Espejo-Saavedra, G Cunliffe, G Grollier, C Ceraulo, T L To, Q H Tran, M Anscombe, R Jordan, I Czuriga, P Haimes, R Ancín Viguiristi, H Q Zhang, C A Chételat, A Rafter, E Rinkūnienė, K Yang, W Gao, J Pearce, L C Fernández Léoz, L Gareeva, R Fernández Alvarez, G Verret, P Astrakhantseva, C M Chu, L Murphy, P A Do, J L Liu, A Clifford, K Woollard, N Dmitrieva, N Lousada, R Díaz Juárez, N Semenova, T Fesenko, F Henschel, R Amini, G Matuszewska, R Christodorescu, J Varaldi, S Varughese, V Lafarenko, A Ashford, J L Colomer Martín, S Assouline, H Noor Hasni, A Weatherup, T Forster, R Kaserbacher, I Caldwell, N Arabadzhi, Emmanuel Sorbets, A Rink, E C Rueda Calle, J M Stordeur, P West, V C Do, Béla Merkely, J Antunes, U Altmann, S Magheru, B Bachmann, W Parkar, M de los Reyes López, M Wazana, A Frattola, M Mospan, V Koval, E Giusti Rossi, J Vasconcelos, K B Do, A Ogorodnichuk, D Lighezan, G Mentz, J M Cherry, P Pouderou, M Moretti, C M Spinu, Emmanuelle Vidal-Petiot, N Kupstytė, P Jourdain, V Voronina, O Varezhnikova, S Williams, H AlFaleh, R Lew, P Hildebrant, J Drozd, G Muscio, T H Ashton, A Achilli, J Harinasuta, T Ghose, G Walawski, Y Arkhipova, M Alves Costa, B Day, A Suntinger, A Singh, P Sheringham, A Vázquez García, J Taggeselle, J T Dong, T H Goh, G Rojas, R Schultz, A Ballet, O Likhobabina, Z M Qian, S Sandoval Navarrete, D Manzi, S Langridge, W Haerer, C K Abdullah, L Hay, Á Herdade, A Gałuszka-Bilińska, F Biausque, V M Lai, D S Eccleston, L Nikolaeva, P Kalaras, J Martínez Redding, N P H Tran, B Wauer, Philippe Gabriel Steg, B Etcheverry, J Navarro Manchón, R Augarde, C Dixon, M Y Chen, J L Gleizes, S Pustovit, J L Farges, S Cox, G Manchet, K Shein, L Parker, C C Ang, O Sinyukova, V Veth, A Kurekhyan, N Cindea Nica, N Wittlich, J Al Yazeedi, A Pucheu, V Elliott, J Bories, K Alford, M F Ferrão E Vasconcelos, A Adamkiewicz-Piejko, R Cervenak, J F Beltrame, A Castro, L Safonova, G Koutsimpanis, C de Brito Vianna, R Wysocki, V Ginzburg, J Hernández Afonso, A Ihonor, O Golubeva, M Karachaliou, S Kleta, D d'Este, Gustavs Latkovskis, F Jäger, E Gamzatov, Y Kozhelenko, J Lippai, T T L Ong, S J Ge, A Hersi, K Kyd, S Mingam, V Yordanova, L Bardachenko, E Mozerova, S W Liu, J Zdrojewska, E Chung, M Leclair, M Nazir, S Zarechnova, A Rahman, M Sołtysiak, B Maguire, F Moreira Pinto, R Fathi, E Prieto Moriche, C Priftis, P Heno, N Sytilina, A Pladys, S Shimonenko, P Keller, J F Junior, G Amiel Oster Sauvinet, J P Kanner, L Tkachenko, J Dalal, A Liston, D Herrera Fernández, J L Bonnet, A Chirivella González, R P Shah, F A Reyes Cisneros, C Avgerinos, P Ravoala, V Albero Martínez, G Suarez, V Jouve, A Frankiewicz, A Lindsay, A De Meester, H Dau, M Pornin, J Álvarez Gil, J Murin, T Hodac, J J Gómez Barrado, Y J Wu, S Jean, P Hilti, A Dayani, R Steponėnienė, G A Somsen, H Zhang, J Moore, P Tarenidis, T H Nguyen, M Maliszewski, L Voloshyna, S Novo, A Phrommintikul, I Shanina, Roberto Ferrari, P Franklin, C Turner, W Boonyapisit, F Sepulcri, P Vandergoten, J Carvalho, J Halcox, V Rotenberger, J F Baril, M Turiel, P Shiels, P Painsipp, S Reis Monteiro, T Honsig, V Vivekaphirat, J Ardill, P Brodzicki, A Khalifa, H Audibert, T Wettstein, F Auhser, D Ezekiel, D Pella, E Simarro Martín-Ambrioso, H S Seo, J A Núñez Gamero, Gabriel Steg, M Orbán, S Bykovskaya, W Gadziński, N Rozkova, G H M Vawda, R A Motyer, B Limeres González, E Fernandez Valadez, Riyaz S. Patel, I Shaikh, E Ziak, A Estriga, P Dodemant, Dragos Vinereanu, W Miao, L Marullo, F MacNamara, S K Tan, N Giacomantonio, A Leherissier, H W Li, Arpana Agrawal, Y Moreau, F David, S K Ma, A N Jamaluddin, E Alegría Ezquerra, Scalzo, M C Ta, T T Nguyen, A Sudre, R Gupta, H Lagioia, M Haiba, P Kohan, M Szentivanyi, T Dmitrieva, N Vechtomova, C Vuille, R G Schena, P Navratil, O Tsygankov, L Saaby, P Lefebvre, S King Wong, S Maheas Morlet, N H Pham, P Bonnet, S Modi, L Gaspar, M Karlicek, S Pallie, H T Pham, S Abele, N Bizyaeva, L Facila Rubio, N Meneveau, G Poluyanova, J Calaça, S Orazi, M Emonts, A Yusufali, V Sprott, Z Vazhdaeva, M R Conte, E Bulakhova, K Giokoglu, E Page, E Kotova, G Maragoni, C Jerjes Sánchez, T Kiver, M Brunehaut Petaut, A Nagy, P Singer, Zs Sziegl, B Fontanet, S Strange, A Watson, J Föchterle, Janet A. 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Burgess, X P Chen, Hywel C Williams, V T Le, N Gurianova, R Duchowska, V P Nair, D Mitropoulos, A Allcock, T T H Bui, M Golub, E Yakovenko, M Perry, F Belcastro, K Svolis, B H R Forge, F Fernández de la Cigoña, N Murga Eizagaechevarría, G Mariano Pêgo, V Mincheva, T N Nguyen, J Moyal, M Wei, H Vinhas, A Batalla Celorio, C Romero Menor, S Rahman, N Hassler jun, F Duclos, K Ladha, A Ordóñez España, B C Chang, R Cortés Sánchez, G Lafrance, I Mihailova, Y Riou, I Pashentseva, S Tantillo, U Casas Juarezy, Ian B. 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Velez Edwards, A Buakhamsri, N Bazargani, U Spengler, M Toringhibel, M A Matos, I Skoczylas, V Arrarte Esteban, J Fuertes Beneitez, V Gil, L U P Tran, A Mehta, A Álvarez Sangabriel, P Di Pasquale, K Egstrup, P Choudhury, S Whetstone, T S Chee, M Elkohen, P Martina, J Martínez Rivero, C Arden, J Walczewska, I Benett, R Silvestri, V García Saavedra, J Słaboszewska, A Thomson, S Revienė, A Szpak, V Challenor, F Saporito, P Ruiz Pérez, Vives, H M Li, I Sadykova, D Lawton, T Kuzmina, R Elias, D Troup, P Dehayes, J Vavougios, V Pernice, P Tanielian, R Cabrera Solé, T Pitsch, R Nethononda, P Poinson, A Tavares E Taveira, J Yi-MingCha, J Y Hwang, T Haghfelt, C García Pindado, N Bilous, A Kotsalos, M Bariaud, A Drzewiecka, L Polkina, V Arfaras, P Vymetal, J Rawal, A Aumjaud, H P Wang, L Wu Amen, J Fernandes, F Howie, A Ouguoujil, M H Ngo, J A Bertarini, A Malysheva, G De Geeter, N Aimouch, R Parkin, H Taylor, M Kittipovanonth, A Gupte, S Ramanaidu, L Basto, A Zherebtsova, T Arsentieva, V Männl, Y L Cham, J J Gómez Doblas, D Ennouchi, Iveta Mintale, A Vance, R Jirmar, L Boikova, D T Le, P Srivastava, L Tonet, M Liautard, C Proto, Q H Do, Mª A Pérez Martínez, R Stankevičius, L Semedo, M Anghel, I Nikolaeva, J Janes, H Al-Backer, M C Escourrou Berdou, O Leshchuk, D Reshotko, V P Dang, I Édes, L Schlueter, B Sikorska-Buczkowska, K Hatalova, I Marozsán, S Gessner, J Gmehling, M Kuzmicheva, Z Huang, L Kosareva, D K Kumbla, A Baika, F El-Shaer, T Voronova, J M Chopo Alcubilla, A Veternik, S Mohr, D Garcia, J Y Rhew, C K Yeo, C De Niel, H K N Nguyen, E Orts Soler, J Dubrava, S Natarajan, M S H Khan, U Kossowska, J P Detienne, T T H Nguyen, I Centa, M G Millauer, Jose Lopez-Sendon, J T Counsell, E Galehr, T Schröder, L Frost, P P Singh, C Moya López, R Beyer, L Carpentier, J Carrillo Calvillo, Z M Du, R Steeds, E Horstkotte, P Kindler, P Johnson, M Sander, I Rodríguez Tejero, F Azar Manzur, S Brown, M Odín de los Ríos Ibarra, C K Choor, M A Sadiq, D B Gysan, V B Doan, A Gueusquin, M Andrews, L L Feng, B Martina-Hooi, S R Shetty, Y Dascotte, E T Ch'ng, P Dematteo, A Woodall, S Gabriilidis, Jean Ferrières, S K Oh, J Lindford, S Blignaut, L Macedo, R Carrillo Cardoso, Y C Lai, C Lang, S R Jayasinghe, B Bastian, V Sanfins, J de Jeús Zuñiga, F X Meriaux, G Sepp, S Molotyagina, S García Ortego, T Perger, Y Lukina, J H Wirtz, A Regulska, P Durand, P Loheac, J Sinnadurai, S Avlonitis, J García-Moll Marimón, J Bradley, K Pareathumby, L Latyntseva, D Stergiou, K Ling, S K Hong, N S Chonkar, C Goldie, C C Koo, A Salustri, Y Peneva, I Rodríguez Briones, P Ferreira, L Franskyavichene, G Bragança, C Rodrigues, S H Lee, L Dang, B J Lubelsky, L Weinrich, E Hoffer, J Tricoire, M Marachli, O Smirnova, C Falces Salvador, A Mobeirek, M Fagan, A Serazhim, M M W Yeung, F Petitjean, I Cullen, J Benacka, Yañez Wonenburger, D Gentille Lorente, J Ferreira Dos Santos, F Bosa Ojeda, N Marchionni, L Brottier, P Keelan, D Kerö, L Moretti, R Seabra Gomes, I Jasinkevica, P Purnode, D Relange, H N Luqman, A Petit, I Hamilton-Craig, E Kochurov, P Berry, P Aguar Carrascosa, M Noble, S Yvorra, N Razzaq, J M Walch, L Lenartowska, R Sethi, W Kim, C Killeen, S Kurochkina, N Capuano, P Sampson, K H Mak, T Bouchaya, J Hellermann, M Geneves, F Ramos Ariznabarreta, J L Mougeolle, J Ferreira, T Roy, J de Andrés Novales, J F Monteiro Ferreira, M S Mayer, N Lopez Cabanillas, P Touzet, K H Ng, F Pelier, T K Huynh, J Schindler, T Krechunova, A Gaglione, Z Fras, P Haralambus, R Pradhan, L P Low, G Odent, M Sidor, R Sopia, D Janody, T K Ong, K Adamaszek, G Vives Boniato, T Maxwell, H Charles, D Gough, O Dibon, A A Abdul Rahim, H B Liew, S Tikhonova, I Bläse, J Chambel De Aguiar, E Santas Olmeda, M Rosseel, R Angela, D Savard, C Cernetti, O Huttin, J Calder, O Kilaberiya, A Elkrail, I I Tulevski, A Ilyukhina, E Chalkiadakis, R Antonicelli, H C Gwon, G Bautista López, G Brown, J Kojelienė, R Zeitouni, J Mimoso, N Better, N H Vu, H Abdel Wahab, B Poprawa, F Weber, A Ghicu, K Rybak, G Fouquet, C Pindado Rodríguez, A Salakhova, L Isaeva, M H Fallacher, J Placke, G McCansh, V D Tran, O Gusev, D Enayat, P Khera, E Brice, G Levesque, A Alvarez Auñon, M A Arnau, M A López Aranda, E Andreicheva, I Kruck, R Grigoriu, I Sainz Hidalgo, M Węglarz, A Ajani, I Khudina, T Makhieva, V D Dang, R Testa, E Cisowska-Drozd, F Giacomazzi, R Cierpka, Nicola Greenlaw, P Wong, L Simões, L Tsaryabina, O Gureeva, R Raffelsberger, H Luquez, A Rainbird, D Evéquoz, M A Balice-Pasquinelli, R Massay, K L Joseph, I H Chae, R Herrmann, I Salecker, A Montero Gaspar, P F Fonseca, A Martin, W Czarnecki, R Motomancea, E Dechoux, M Shamsuzzaman, M Leandri, D Marzal Martín, C Navas Navas, C Beaurain, T Gkinis, K Shetty, P A Jeannerat, D S Wong, A Gonzaga, W Kulig, J F Millet, E Jankauskienė, E Anastasiou, A I Ruhani, N Aksyutina, O Kolesova, K Yared, M Panajatovic, Y L Zhou, S Thurston, T Alekseeva, S Preston, N Mai, M Kuzyakina, D Rechtman, T Boonyasirinant, J Nobre Dos santos, A Ahuad Guerrero, M Al-Shamiri, M Feldner-Busztin, S Godart, S Liandrat, A Narayan, L Burlakova, M J García Martínez, C Militaru, J Chávez Paez, H B Matheson, D Meddah, P Brindle, N Petrova, A Nicolino, D Spensieri, A Giuca, E Molina Laborda, J Moreno Arribas, V Martinho, T Mularek-Kubzdela, S K Chua, G A Dan, N T H Tu, V T Nguyen, M Alcocer Gamba, J Costa, H Milligan, R Badr-Eslam, E Variava, A Merkhi, C Mays, R De Castro Aritmendiz, A K Mohamed Yusof, A Hamer, R McNeilly, S Dedkova, D Rousson, K Chamou, A Mahr, D C Dan, R Till, T L Yang, M Vida Gutiérrez, D Piyayotai, É Bajcsi, D Zaronskienė, I Alexopoulos, Y Huo, H S Zeng, P Rowe, S Fleming, D B Vu, Á Dongó, C Hand, J C S Leong, M Claeys, S Hood, J Bozkova, G Vieyra, G Unger, A Liqui-Lung, D Cremer Luengo, M Castillo Orive, S Muth, M Joseph, P L Torres Díaz, C Zakopoulos, D Cross, F Trujillo Berraquero, F Sattar, H A Boyrazian, T B Le, M Mantcheva, M Constantinescu, P Gosse, U Keil, G F Vaz, M Bdeir, T S Pham, M J García González, J K Ryu, D W Jeon, Zs Malkócs, J Á Perea Egido, R Izquierdo González, V Probst, E Wellenkamp, C Boureux, M Czarnecka, C Vaughan, H Falconer, H Brunner, G Peña Pérez, E Nelböck-Huber, E Blanc, F Thomas-Richard, A L R Ng, M Provvidenza, R Gascueña Rubia, J Freitas, A Dabboura, B Mörz-Proszowski, A Utech, C Alves, C M David, J A Lastra Galán, L Oliveira, T A Nguyen, I Ghaly, A Hofmeister, I Gorodilova, P Szałkowski, M S Hiremath, G Golovina, C Daly, M Tardy, S Kostomarova, J-P Salembier, P Zagožen, D Wang, M Vogel, J Borbola, I Chlewicka, K-H Schmitz, C Pappas, J Victory, M Garandeau, P Wiggers, C Piñero Ramírez, L Tkhorzhevskaya, E Suglobova, V Samakhovets, P Surmont, H A Ramírez Reyes, M Winter, F Prunier, B Cavert, B Salaun, J M Roca Catalán, A Beinhauer, Ian Ford, K Elsby, V Knyazeva, C Tamburino, V Khoury, A Felice Castro Issa, B Marchenko, K König, A Kennedy, J M Alegret Colomer, T Gillet, Clarify Investigators, B Maheu, A Troncoso Gil, N Haldane, B Koujan, T Mouhat, A Waldman, J Robert, J Campbell, A Kokis, M Micheals, P Gori, P Ramoutar, M Al Zaibag, V Ryzhkova, M Kazakovtseva, C Bernardeau, B Ferreiro Rodríguez, Y Voloshko, S Szabo, I Jarvis, Y N Ke, J Donetti, A Serrano-Garcia, R Ketelers, S Grigoryan, V Kulik, P Zündorf, L Kleemann, J McPherson, M Luaces Méndez, F Mouquet, L G Xiong, T H Tran, P Costello, A Potter, M Cinteza, F Colivicchi, E Nowicka, O Greiner, G Reddy, M Martins Oliveira, F Fernandes De Sousa, P Nocon, R Sewell, I Nikodemska, R Tadeu Munhoz, T Gilbert, I Laizane, M Maroun, B Demianiuk, A Bolidai, R Kacorzyk, R Fernández Mouzo, K Karastanev, J Blanco Castiñeiras, P Messali, R Schwarz, M Vardhani, O Gouli, C Thelemann, A Forclaz, G Khaznadar, G Eisele, P Sosner, M L Bourachot, N Pontikakis, S Heinemann-Meerz, E Zatsarina, E Smrckova, P Calmettes, D H Kang, M L Santos Iglesias, S M Marinescu, A Heap, Melnikova, N F Strathmore, S Tolpygina, M Yang, M Naisseh, E George, J Banach, E Delcoulx, E Teijeira Fernández, J Poles, P Saunders, S Haddad, T Q Luu, A Dhesi, O Prikolota, M Baar, P Lafontaine, C O'Dong, I Petropoulos, B-M Altevogt, D Warden, T De Backer, G Miñana Escrivá, T L Mai, U Schlesinger-Irsch, M M Gomaa, E Moksyuta, M Drexler, P Monteiro, P Grooterhorst, J Moolman, P McAlavey, J O'Shea, L P Quinn, F Crespo, K Srinivasa Reddy, T Shokina, Ellen M. Schmidt, M H Jeong, K Denef, A Pleskof, I Takács, Y Tikhonov, O Ushakov, L Stevens, J Ezcurdia Sasieta, L Nkombua, O Henne Otero, J Y Fraboulet, D S Kim, G Hoh, A Tamm, M Sardon, G Chatzioakim, M A Ulecia Martínez, S Reymond, M Myint, G Proença, R Massabie, E Foster, H Dougall, Anjan Kumar Roy, C Franco Aranda, M Getman, E Filippova, C Aguiar, X D Pu, N Voronina, L L Chen, M Szulc, L Bayakhchan, M J Pinto Vaz, C Niederberger, N Vites, I Sen, Paul R. Kalra, J A Castillo Moreno, W K Ng, C Brunschwig, D Morgan, A Concepción Clemente, N Yakimova, J M Guy, A H Jaafar, J Badarienė, N Taylor, L Compson, R Amor, A Maximovitch, J L Bardají Mayor, E Marín Araez, N H Chau, N Srtumilenko, K Kelly, A Papathanasioy, S Erofeev, B Mamez, A Ribeiro, M Micko, N Alvarenga Recalde, K Atueva, Z Sebõk, P Kycina, A K Gupta, A Laucevičius, R Ahuja, A Prokop, P Stadler, S De Ridder, L Zhang, F B Ramadan, L Kapustina, V Fedoskin, A Bateman, C A Nacht, R Musetescu, M Aparici Feal, A Büttl, S Ross, M Rau, P Federico Zaragoza, G Brisson, M Zagreanu, T T H Pham, F Dominé, N Davydova, N Petrochenko, N Paul, P H Truong, S Frickel, W Bryl, G Brouillette, A Stumpp, M Barrera Bustillos, C Ziccarelli, O Zalyzniak, M eatherhead, N Watkins, G Riccioni, l Kudryavtsev, R Carvalho, J P S Sawhney, V González Toda, P Matos Dias, M Giorgadze, I Rodriguez Marrero, W Gritsch, K Lee, G W Kellam, I Parker, V Ecina, Mª I Soto Ruiz, C Delhomme, T Ivaschenko, Y W Cheah, I Grudtsina, R Chehayeb, T Dookie, O Krasnoslobodskaya, P Jarmużek, F Van den Branden, A M F Vandeplas, A Rocha De Almeida, M Espiga De Macedo, E Łotocka, K Nagy, R Paliulionienė, J L Leyva Pons, N Fedorova, Y Yanina, O Stasuk, Z Vlasuk, P Lim, P Egloff, T Berezhna, A Faria, J Cerda Rojas, E Moser, H G Jin, S J Oh, G Arquero García, K H Karner, I Leontaridis, A Banikova, J Fridrich, H Lesseliers, I Pokrovskaya, P Astridge, H Abdul Manap, R Daniel, C A Almeida Fernández, A Nowowiejska-Wiewióra, B Carvalho De Moura, M Malden, H Rosenstein, S Dixon, G Balogh, M Adam-Blanpain, A Sandalian, H Gervas Pavón, G A Antoniadis, N Naberezhnova, A Amlaiky, P Terrosu, K K H Lau, B Chartier, X Su, O Kovyrshyna, G Beale, P Primot, M H Chen, S S Ramesh, R Chyrek, E Gómez Álvarez, J Rodríguez Collado, G Sibilio, R Jeremiasz, R Colin, C Lalla, G M Fullerton, M P Samal, H Thümmel, R P Patel, J Takhar, H M Kwon, T A Cieza Lara, F Magliari, J Morrell, M Rayo Gutiérrez, T L Orenstein-Lyall, H Choi, S Kulinich, A Aftab, A Wallace, B B Abdul Kareem, S Kwok, A Królak, A Grover, Laurent Fauchier, Mª J Pinilla Lozano, G Sengupta, D Paris, M Al Dhanki, J Milewski, F Petersen Aranguren, H Brufau Redondo, H Mayr, A Arias Mendoza, M Ducoudre, A Correia, J S Awtar Singh, P Aylward, E Brscic, J Du Plooy, J L Arenas León, G Silva Alves, L Sreenivasa Murthy, P Dendale, F La Varra, S Minkin, T Eggeling, A Jamiel, G Lebischak, E Andreev, T V A Tuong, V Chaithiraphan, O Duprez, S Higgins, F Chometon, Y Cottin, A Bonny, C Guyetand, J Matos, F Henpin Yue Cesena, L Polyaeva, M Drijfhout, J Toplak, G E Vertes, N F Wang, J Doucet, A K Trivedi, P Turek, G Chouinard, A Al Lawati, W Filip, F Kovar, T J Cha, A Belanger, H L Cong, J F Robert, D López Gómez, J L Sanz Rodríguez, H Simper, P Shetty, A Chukwu, E Bukanina, C Amoros Galito, H MacCowan, T T T Tran, A Singal, K C Vu, O Ismail, A Ardiaca Capell, P Bousquet, F Goss, Z Galeeva, Maxime Guenoun, B Rijavec, Z Lazerevic, A McCracken, A C Motoc, Y Sharapova, S Wright, A J Paule Sánchez, L Mainar Latorre, I Sirazov, X L Yang, S E Paget, G Berkenboom, J Markenvard, I Surovtseva, S K George, Matthias Simon, M L Fuantos Delgado, C Christoforidis, M Lagares Carballo, P Alvarez García, J Könemann, L Crawford, I Gonos, D Saulnier, E Szabó, L Ardouin, J Bhayat, F J Abardía Oliva, X Bernard, O Sirbu, P Boutsikos, N Khmelevskikh, E Tavlueva, P LeBouthillier, I Bourazanis, A Sequeira, M López Martínez, C P Paulus, R K M Bhaskaran, F Pellerin, B Brown, B Saleh, A Lacchè, R Sola Casado, E Kaźmierczak, M Weingrod, and G Vijayaraghavan

Subjects
medicine.medical_specialty, Cardiac & Cardiovascular Systems, Epidemiology, LONG-TERM, medicine.medical_treatment, Chronic coronary syndromes, Coronary Artery Disease, Revascularization, Ventricular Function, Left, GLUCOSE, MELLITUS, Risk Factors, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Ethnicity, Prevalence, medicine, Humans, ARTERY-DISEASE, Myocardial infarction, Stroke, RISK, OUTCOMES, Ejection fraction, Science & Technology, business.industry, Proportional hazards model, CLARIFY Investigators, Hazard ratio, Diabetes, Stroke Volume, Geographical disparities, Syndrome, medicine.disease, MIDDLE-EAST, EUROPEAN-SOCIETY, Treatment Outcome, MYOCARDIAL-INFARCTION, Heart failure, CLARIFY registry, Cardiovascular System & Cardiology, HEART-FAILURE, Cardiology and Cardiovascular Medicine, business, Life Sciences & Biomedicine
Abstract

BackgroundIn contrast with the setting of acute myocardial infarction, there are limited data regarding the impact of diabetes mellitus on clinical outcomes in contemporary cohorts of patients with chronic coronary syndromes. We aimed to investigate the prevalence and prognostic impact of diabetes according to geographical regions and ethnicity.Methods and resultsCLARIFY is an observational registry of patients with chronic coronary syndromes, enrolled across 45 countries in Europe, Asia, America, Middle East, Australia, and Africa in 2009–2010, and followed up yearly for 5 years. Chronic coronary syndromes were defined by ≥1 of the following criteria: prior myocardial infarction, evidence of coronary stenosis >50%, proven symptomatic myocardial ischaemia, or prior revascularization procedure.Among 32 694 patients, 9502 (29%) had diabetes, with a regional prevalence ranging from below 20% in Northern Europe to ∼60% in the Gulf countries. In a multivariable-adjusted Cox proportional hazards model, diabetes was associated with increased risks for the primary outcome (cardiovascular death, myocardial infarction, or stroke) with an adjusted hazard ratio of 1.28 (95% confidence interval 1.18, 1.39) and for all secondary outcomes (all-cause and cardiovascular mortality, myocardial infarction, stroke, heart failure, and coronary revascularization). Differences on outcomes according to geography and ethnicity were modest.ConclusionIn patients with chronic coronary syndromes, diabetes is independently associated with mortality and cardiovascular events, including heart failure, which is not accounted by demographics, prior medical history, left ventricular ejection fraction, or use of secondary prevention medication. This is observed across multiple geographic regions and ethnicities, despite marked disparities in the prevalence of diabetes.ClinicalTrials identifierISRCTN43070564

Published
2021

339. Mix design and laboratory characterisation of rubberised mixture used as damping layer in pavements

Author

Giacomo Cuciniello, Massimo Losa, Jiandong Huang, and Pietro Leandri

Subjects
050210 logistics & transportation, Materials science, Rut, 05 social sciences, Phase angle, 0211 other engineering and technologies, 02 engineering and technology, Mix design, Damping, rutting, phase angle, Vibration, Mechanics of Materials, Asphalt, 021105 building & construction, 0502 economics and business, Dynamic modulus, dynamic modulus, rubberised asphalt mixes, vibration, Composite material, Layer (electronics), Civil and Structural Engineering
Abstract

Road authorities are challenged by traffic-induced vibrations due to their detrimental effects on humans and to the damage of buildings and structures. For this reason, asphalt mixtures designed as...

Published
2021

340. Impact of the polycarbonate strippers used in assisted reproduction techniques on embryonic development

Author

C Naylies, Y Lippi, M Guilleman, Patricia Fauque, N. Gatimel, Véronique Gayrard, G Tavenier, A A Huesca, Jean Parinaud, Roger Leandri, Jessika Moreau, CHU Toulouse [Toulouse], Groupe de recherche en fertilité humaine ( GRFH), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Transcriptomic impact of Xenobiotics (E23 TRiX), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), UMS006 Service d'Experimentation Animale, Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe 7 Inserm U1048, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biologie de la reproduction CECOS - [CHU de Dijon], Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe GAD (LNC - U1231), Lipides - Nutrition - Cancer [Dijon - U1231] (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Université Bourgogne Franche-Comté [COMUE] (UBFC), Innovations Thérapeutiques et Résistances (InTheRes), Ecole Nationale Vétérinaire de Toulouse (ENVT), Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), ToxAlim (ToxAlim), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Chronic exposure, bisphenol A, [SDV]Life Sciences [q-bio], Preimplantation Embryos, Biology, Andrology, Embryo Culture Techniques, 03 medical and health sciences, 0302 clinical medicine, In vivo, Pregnancy, medicine, Humans, Blastocyst, 030304 developmental biology, 0303 health sciences, 030219 obstetrics & reproductive medicine, Zygote, Polycarboxylate Cement, Rehabilitation, Embryogenesis, Obstetrics and Gynecology, Embryo, ARTs, Embryonic stem cell, Europe, medicine.anatomical_structure, Reproductive Medicine, polycarbonate, embryonic development, [SDV.TOX]Life Sciences [q-bio]/Toxicology, Female, transcriptome
Abstract

STUDY QUESTION Do daily manipulations of preimplantation embryos with polycarbonate (PC)—made bisphenol A (BPA)—releasing strippers influence embryo development? SUMMARY ANSWER Compared to glass strippers, PC strippers enhance the blastocyst development rate but this does not seem to be BPA-related. WHAT IS KNOWN ALREADY PC strippers have been shown to release tiny amounts (around 0.5 ng/ml BPA) of BPA in routine human IVF procedures. A chronic exposure to BPA either in vivo or in vitro during the preimplantation period can impact post-implantation and post-natal development. BPA can act rapidly by binding to membrane receptors and inducing rapid non-genomic effects. STUDY DESIGN, SIZE, DURATION This experimental study using mouse embryos had a balanced design and blinded evaluations of the endpoints. PARTICIPANTS/MATERIALS, SETTING, METHODS In vivo fertilized zygotes were obtained from outbred Swiss CD1 mice crossings after an ovarian stimulation. The zygotes were allocated to three daily handling conditions (HCs) and cultured until Day 4 in a single human commercial medium. Each day, the embryos were handled for 20 s either in a PC stripper (HC1) or in a glass stripper (HC2). In HC3, the embryos were pre-exposed to 0.5 ng/ml BPA before being handled for 20 s in a glass stripper. Handling operations were repeated on Days 1, 2 and 3. Embryo development was assessed blindly on Day 4. Expanded blastocysts were selected for a transcriptomic analysis using Agilent Sureprint G3 Mouse GE v2 microarrays and the retrotransposon LINE1-Orf2 expression was analysed using qRT-PCR, as a proxy for a global evaluation of the epigenetic status. MAIN RESULTS AND THE ROLE OF CHANCE Compared to the embryos manipulated in HC2 (n = 243), those in HC1 (n = 228) developed significantly more often to the blastocyst stage (55 vs 46%; P LARGE SCALE DATA https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE148868. LIMITATIONS, REASONS FOR CAUTION Our results using a mouse model designed to mimic human conditions (outbred strain, human commercial IVF dishes and a unique commercial human embryonic culture media) are reassuring since no gene was found to be differentially expressed, including LINE-1 genes, as a proxy for a global evaluation of the epigenetic status. However, no global epigenetic analysis of the genome has been performed. Furthermore, we did not evaluate post-implantation events, although BPA exposure during peri-conception could affect foeto-placental and post-natal development. WIDER IMPLICATIONS OF THE FINDINGS Based on the precautionary principle, several European countries banned the use of BPA in baby bottles and food packaging several years before European Agencies took an official position. The question of applying this principle to plastics in closed contact with human embryos is raised. Further studies are needed for a decision to be made. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by a grant from the Agence de Biomédecine (AOR 2016). The authors declare no competing interest.

Published
2021

341. Cantarell Giant Oilfield Fault-Thrust Kinematic Evolution and Synchronous Thermo-Fluid Dynamics

Author

G. Pérez-Drago, J. Faure, G.A. Pérez-Cruz, and P. Leandri

Subjects
geography, geography.geographical_feature_category, Field (physics), Continental shelf, Fold and thrust belt, Fluid dynamics, Thrust, Kinematics, Fold (geology), Fault (geology), Petrology, Geology
Abstract

Summary The Cantrell complex, located in the continental shelf in the Southern Gulf of Mexico, is a naturally fractured carbonate field discovered in the late 70’s by PEMEX. The main field known as Akal is the largest with 32 Bboe OOIP. Underlying the Akal filed, the namely Sihil field (1.2 Bboe OOIP) constitutes the thrusted footwall block of a complex fault propagation fold and thrust belt structure. Even if the Cantarell complex has been studied for several decades and its exploitation reaches a mature declination stage, several questions remain related to the physical and geochemical processes occurring during the trap fold thrust evolution and the synchronous thermo-fluid dynamics: How was the thermal-pressure evolution between the overlying Akal and the Sihil footwall during fold thrust formation? What was the timing of HC expulsion and the fluid migration interactions between both blocks? How was the evolution of the fluid composition and PVT phase behavior during HC charge? What are the implications for near field exploration (NFE) and field development? The applied methodology is a 2D structural kinematic restoration meshing tool (KronosFlow), coupled with a fault-related petroleum system modelling (TemisFlow) and detailed 1D reservoir fluid PVT phase behavior modeling.

Published
2021

342. Predicting international roughness index by deep neural networks with Levenberg-Marquardt backpropagation learning algorithm

Author

Massimo Losa, Nicholas Fiorentini, and Pietro Leandri

Subjects
International Roughness Index, Artificial neural network, Mean squared error, Computer science, business.industry, Deep learning, Falling Weight Deflectometer, Non-Destructive High-Performance Techniques, Overfitting, Levenberg Marquardt Backpropagation Algorithm, Ground Penetrating Radar, Backpropagation, Data Fusion, Non-Destructive High-Performance Techniques, Data Fusion, Deep Learning, Artificial Neural Networks, Levenberg Marquardt Backpropagation Algorithm, International Roughness Index, Falling Weight Deflectometer, Ground Penetrating Radar, Levenberg–Marquardt algorithm, Falling weight deflectometer, Deep Learning, Artificial intelligence, business, Algorithm, Artificial Neural Networks
Abstract

This paper proposes a methodology based on Artificial Neural Networks (ANNs) for integrating products derived by three on-ground Non-Destructive high-performance Techniques (NDTs) to estimate the International Roughness Index (IRI) of flexible road pavements. About that, IRI of 93 two-lane road sections has been detected by a Laser Profiler (LaP) and considered as output target to be predicted. Structural and geometrical road pavement parameters recognized by Falling Weight Deflectometer (FWD) and Ground Penetrating Radar (GPR) have been considered as input features, along with climate and rainfall information. Accordingly, different ANNs architectures have been trained (by using 70% of samples), validated (15% of samples), and tested (15% of samples) by the Levenberg-Marquardt (LM) backpropagation learning algorithm. We chose the LM since it allows handling limited data and avoiding overfitting issues. Outcomes reveal that a Deep Neural Network (DNN) recognizes hidden patterns between different road surveys and made the integration of NDTs possible and reliable. Specifically, a DNN architecture composed of two hidden layers containing 23 and 12 artificial neurons, respectively, shows a Determination Coefficient (R2) of 0.813 for the training phase, 0.761 for the validation phase, and 0.741 for the test phase. Also, the residual distribution is Gaussian with zero mean. Supported by these findings, we have deployed the DNN including all road sections, obtaining an R2 parameter of 0.762 and a Root Mean Square Error (RMSE) of 0.450 mm/km. Road authorities can consider ANNs and the LM backpropagation learning algorithm for appropriately predicting IRI and efficiently integrating NDT-based outcomes.

Published
2021

343. La sépulture mégalithique de Contra Maiò (Casalabriva, Corse-du-Sud) : premiers résultats des campagnes 2018-2019

Author

Cesari, Joseph, Peche-Quilichini, Kewin, Bressy-Leandri, Céline, Conforti, Jacopo, Lambert, Maryline, Le Bourdonnec, François-Xavier, Leck, Arthur, Martinet, Lauriane, Meirone, Coralie, Institut national de recherches archéologiques préventives (Inrap), Travaux et recherches archéologiques sur les cultures, les espaces et les sociétés (TRACES), École des hautes études en sciences sociales (EHESS)-Université Toulouse - Jean Jaurès (UT2J)-Ministère de la Culture et de la Communication (MCC)-Centre National de la Recherche Scientifique (CNRS), IRAMAT-Centre de recherche en physique appliquée à l’archéologie (IRAMAT-CRP2A), Institut de Recherches sur les Archéomatériaux (IRAMAT), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM)-Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS)-Université Bordeaux Montaigne-Université de Technologie de Belfort-Montbeliard (UTBM), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), and Jean Sicurani

Subjects
[SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2021

345. Développement et validation d'une solution d'intelligence artificiellepour évaluer la qualité de la préparation intestinale en vidéocapsuleendoscopique du grêle

Author

Dray, Xavier, Leenhardt, Romain, Souchaud, Marc, Houist, Guy, Le Mouel, JP, Saurin, J.C., Cholet, Franck, Rahmi, Gabriel, Leandri, Céline, Quénéhervé, L., Histace, Aymeric, Histace, Aymeric, Equipes Traitement de l'Information et Systèmes (ETIS - UMR 8051), Ecole Nationale Supérieure de l'Electronique et de ses Applications (ENSEA)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), CHU Saint-Antoine [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
[INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], Videocapsule, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Apprentissage Profond, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Propreté, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract

International audience

Published
2021

346. Use of recycled oils as rejuvenators for bituminous binders

Author

Norma Mallegni, Miriam Cappello, Sara Filippi, Pietro Leandri, Giovanni Polacco, and Massimo Losa

Subjects
TK7885-7895, Computer engineering. Computer hardware, Chemical engineering, TP155-156
Abstract

The addition of rejuvenators agents (RJ) into bitumen allows increasing the amount of recycled asphalt in new mixtures. In the preliminary part of this study, three different type of oils were tested as potentials RJ: a mineral oil from the automotive industry, a waste domestic cooking vegetable oil (VO), and a biodiesel. Several mixtures were prepared by adding different percentage of oils and VO was individuated as the best RJ. Therefore, VO was used in a further investigation, to better characterize the properties of the rejuvenated binder and its resistance to aging during a second life cycle. Rejuvenated binders with different oil content were prepared and evaluated. The rheological characterization included frequency sweep tests to obtain the binder master curves and linear amplitude sweep test to evaluate the cumulative damage resistance. Moreover, the molecular weight distributions of the binders were investigated by both gel permeation chromatography and rheology by application of the delta-method.

Published
2021

347. A Bad Start in Life? Maternal Transfer of Legacy and Emerging Poly- and Substances to Eggs in an Arctic Seabird

Author

Jouanneau, William, Leandri-Breton, Don-Jean, Corbeau, Alexandre, Herzke, Dorte, Moe, Børge, Nikiforov, Vladimir A., Gabrielsen, Geir W., Chastel, Olivier, Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC), Université de La Rochelle (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre FRAM, McGill University = Université McGill [Montréal, Canada], Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Norsk Institutt for Luftforskning (NILU), Norwegian Institute for Nature Research (NINA), IPEV [330], ANR ILETOP French National Research Agency (ANR) [ANR-16-CE34-0005], University of La Rochelle, France, Natural Sciences and Engineering Research Council of Canada Natural Sciences and Engineering Research Council of Canada (NSERC) CGIAR, Fonds de Recherche du Quebec -Nature et Technologies, Northern Scientific Training Program, ANR-16-CE34-0005,ILETOP,Impact des polluants historiques et émergents sur les prédateurs supérieurs marins de l'Arctique(2016), La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), and Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Svalbard, emerging contaminants, black-legged kittiwake, embryonic structures, PFAS, top predator, Rissa tridactyla, [SDE.BE]Environmental Sciences/Biodiversity and Ecology
Abstract

International audience; In birds, maternal transfer is a major exposure route for several contaminants, including poly-and perfluoroalkyl substances (PFAS). Little is known, however, about the extent of the transfer of the different PFAS compounds to the eggs, especially for alternative fluorinated compounds. In the present study, we measured legacy and emerging PFAS, including Gen-X, ADONA, and F-53B, in the plasma of prelaying black-legged kittiwake females breeding in Svalbard and the yolk of their eggs. We aimed to (1) describe the contaminant levels and patterns in both females and eggs, and (2) investigate the maternal transfer, that is, biological variables and the relationship between the females and their eggs for each compound. Contamination of both females and eggs were dominated by linPFOS then PFUnA or PFTriA. We notably found 7:3 fluorotelomer carboxylic acid-a precursor of long-chain carboxylates-in 84% of the egg yolks, and provide the first documented finding of ADONA in wildlife. Emerging compounds were all below the detection limit in female plasma. There was a linear association between females and eggs for most of the PFAS. Analyses of maternal transfer ratios in females and eggs suggest that the transfer is increasing with PFAS carbon chain length, therefore the longest chain perfluoroalkyl carboxylic acids (PFCAs) were preferentially transferred to the eggs. The mean n-ary sumation Sigma(PFAS) in the second-laid eggs was 73% of that in the first-laid eggs. Additional effort on assessing the outcome of maternal transfers on avian development physiology is essential, especially for PFCAs and emerging fluorinated compounds which are under-represented in experimental studies.

Published
2021

348. Measuring Latency Variations in Evoked Potential Components Using a Simple Autocorrelation Technique

Author

Jackie Campbell and Massimo Leandri

Subjects
Article Subject, Computer science, Computer applications to medicine. Medical informatics, Models, Neurological, R858-859.7, Signal-To-Noise Ratio, General Biochemistry, Genetics and Molecular Biology, Evoked Potentials, Somatosensory, Neural Pathways, otorhinolaryngologic diseases, Humans, Computer Simulation, Evoked potential, Latency (engineering), Reliability (statistics), Jitter, Analysis of Variance, Models, Statistical, General Immunology and Microbiology, Autocorrelation technique, business.industry, Applied Mathematics, Autocorrelation, Computational Biology, Pattern recognition, General Medicine, Neurophysiology, Electrophysiological Phenomena, Somatosensory evoked potential, Modeling and Simulation, Artificial intelligence, business, Research Article
Abstract

Interpretation of averaged evoked potentials is difficult when the time relationship between stimulus and response is not constant. Later components are more prone to latency jitter, making them insufficiently reliable for routine clinical use even though they could contribute to greater understanding of the functioning of polysynaptic components of the afferent nervous system. This study is aimed at providing a simple but effective method of identifying and quantifying latency jitter in averaged evoked potentials. Autocorrelation techniques were applied within defined time windows on simulated jittered signals embedded within the noise component of recorded evoked potentials and on real examples of somatosensory evoked potentials. We demonstrated that the technique accurately identifies the distribution and maximum levels of jitter of the simulated components and clearly identifies the jitter properties of real evoked potential recording components. This method is designed to complement the conventional analytical methods used in neurophysiological practice to provide valuable additional information about the distribution of latency jitter within an averaged evoked potential. It will be useful for the assessment of the reliability of averaged components and will aid the interpretation of longer-latency, polysynaptic components such as those found in nociceptive evoked potentials.

Published
2021
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349. Intersection Redesign for Network Resilience and Safety

Author

Rosaria Aiello, Pietro Leandri, Reginald R. Souleyrette, and Antonio Pratelli

Subjects
resilience of road facilities, 050210 logistics & transportation, Computer science, 05 social sciences, Traffic model, lcsh:TA1001-1280, Ocean Engineering, resilience, traffic system resilience attitude index and metric, urban local, Reliability engineering, Identification (information), Intersection, 0502 economics and business, Resilience index, urban local network micro-simulation, lcsh:Transportation engineering, Resilience (network), Baseline (configuration management), Engineering (miscellaneous), Civil and Structural Engineering
Abstract

This paper describes a procedure for improving the resilience of roadway networks. A methodology is outlined that develops a time-dependent and performance-based resilience index. This methodology was applied to an Italian road, with the aim of optimizing intersections that are critical due to inadequate baseline capacity. The methodology uses a calibrated microscopic traffic model (using Aimsun™) whereby average delay at intersection approaches are estimated by an analytical model. From the simulation, average speed over time is obtained for each approach. These values in turn are used as inputs for calculating each intersection’s resilience index. The procedure allows the identification of less resilient intersections, and provides design solutions for each of them. Lastly, a safety assessment is tested for one of the intersections.

Published
2021

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