301. Apolipoprotein E genotypes and Alzheimer's disease in a community study of elderly African Americans.
- Author
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Hendrie HC, Hall KS, Hui S, Unverzagt FW, Yu CE, Lahiri DK, Sahota A, Farlow M, Musick B, and Class CA
- Subjects
- Black or African American, Aged, Aged, 80 and over, Alleles, DNA analysis, Female, Gene Frequency, Genotype, Humans, Incidence, Indiana epidemiology, Logistic Models, Male, Nigeria epidemiology, Prevalence, Regression Analysis, Alzheimer Disease ethnology, Alzheimer Disease genetics, Apolipoproteins E genetics, Black People genetics
- Abstract
As part of a community-based study of Alzheimer's disease (AD) in the African-American population age 65 and over, we have determined apolipoprotein E (Apo E) genotypes in 85 subjects (31 AD patients and 54 controls). The epsilon 4 allele of Apo E was strongly associated with AD in this population sample. The epsilon 4 allele frequency in AD patients was 40.3% compared with 13.9% in the control group, and 22.6% of the AD patients were homozygous for this allele compared with 3.7% of the control subjects (p = 0.01). This study extends the association of Apo E-epsilon 4 and AD to nonwhite populations and provides further evidence that the observed allelic association is biologically relevant.
- Published
- 1995
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