251. EZH2 couples pancreatic regeneration to neoplastic progression.
- Author
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Mallen-St. Clair, Jon, Soydaner-Azeloglu, Rengin, Kyoung Eun Lee, Taylor, Laura, Livanos, Alexandra, Pylayeva-Gupta, Yuliya, Miller, George, Margueron, Rapha, Reinberg, Danny, and Bar-Sagi, Dafna
- Subjects
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POLYCOMB group proteins , *CELL differentiation , *TISSUES , *PROGENITOR cells , *PANCREATIC cancer - Abstract
Although the polycomb group protein Enhancer of Zeste Homolog 2 (EZH2) is well recognized for its role as a key regulator of cell differentiation, its involvement in tissue regeneration is largely unknown. Here we show that EZH2 is up-regulated following ceruleininduced pancreatic injury and is required for tissue repair by promoting the regenerative proliferation of progenitor cells. Loss of EZH2 results in impaired pancreatic regeneration and accelerates KRasG12D-driven neoplasia. Our findings implicate EZH2 in constraining neoplastic progression through homeostatic mechanisms that control pancreatic regeneration and provide insights into the documented link between chronic pancreatic injury and an increased risk for pancreatic cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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