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This report describes the case of a 33-year-old woman with biopsy-proven, active lymphocytic myocarditis manifested by intractable ventricular tachycardia, nonspecific intraventricular block, and myocardial dysfunction. We treated her successfully with OKT3 monoclonal antibody and antiarrhythmic agents. Immunosuppression is not recommended in patients with infectious or postinfectious myocarditis. However, it may have an important role in autoimmune myocarditis. In the few reports in the medical literature that we were able to find, OKT3 monoclonal antibody was administered early, in the setting of acute, fulminant autoimmune myocarditis. Our patient received OKT3 therapy in a later phase of the disease, when inflammatory infiltrates were accompanied by extensive fibrosis and severe damage of cardiomyocytes. Our patient had concomitant Helicobacter pylori infection and a strong positive family history of gastric cancer, a disease often associated with H. pylori. We discuss the possibility of a causal relationship between H. pylori infection and autoimmune myocarditis. (Tex Heart Inst J 2002;29:113-7) [ABSTRACT FROM AUTHOR]

This study aimed to address whether the anthropometric features of the patella can be used to determine the sex of the individuals on the basis of the skeletal remains and to set limit values for anthropometric measurements and indicators of the patella in relation to each sex. 71 patellas (32 female and 39 male) from the Middle Ages from Wroclaw, Poland, were analyzed. The measurements (the greatest height, width, thickness, width of the lateral and medial joint surface and the height of these joint surfaces) and ratios were calculated (height to width, height to thickness as well as width to height of lateral and medial joint surfaces) and tested according to sexual dimorphism. The best parameter in terms of discriminatory assessment was the patella's highest height, which made it possible to classify the sex in 46.5% of cases. However, an index of the sum of the height, width and thickness measurements seems to be even better for differentiating between the sexes, making it possible to correctly classify the sex in 49.3% of cases. Due to some limitations of this study and the need of population-specific standard, it is recommend to employ the patella in sex determination only in cases of fragmented human remains and when no other method can be applied. Further investigation of possible factors influencing the variability of its size and shape should be explored in larger and geographically more diverse samples, and this could contribute to forensic, clinical, anatomical, and anthropological studies in this body part.

During archaeological excavations in burial sites, sometimes stoned organic objects are found, in addition to human remains. Those objects might be of a different origin, depending on various factors influencing members of a community (i.e. diseases, trauma), which provides information about their living conditions. The St. Nicholas Church archaeological site (Libkovice, Czechia) in the 18th century horizon of the cemetery, yielded a maturus-senilis female skeleton with a stone object in the left iliac fossa. This object was an oviform cyst-like rough structure, measuring 54 mm in length, 35 mm in maximum diameter and 0.2-0.7 mm shell thickness. Within the object there were small fetal bones (long bones, i.e. femur and two tibias, two scapulas, three ribs, vertebrae and other tiny bone fragments). Methods utilized to analyze the outer and inner surface morphology of the cyst and its inside, included: X-ray, CT imaging, SEM, histological staining and EDS. The EDS analysis revealed the presence of primarily oxygen, calcium and phosphorus in bone samples, and oxygen and silicon, in stone shell. Based on the length of the femur (20.2 mm) and tibia (16 mm) shafts, the fetal age was determined as being in the 15-18 week of pregnancy. The differential diagnosis was conducted, including for the three most probable cases: fetiform teratoma (FT), fetus-in-fetu (FIF) and lithopedion. The possibility of fetiform teratoma was discounted due to the presence of an anatomically correct spine, long bones and the proportions of the find. Although the low calcium content in the shell (2.3% atom mass), the lack of skull bones and the better developed lower limbs indicate fetus-in-fetu rather than lithopedion, the analyses results are unable to conclusively identify the object under one of these two categories since there are insufficient such cases in excavation material with which to draw comparison., Competing Interests: The authors have declared that no competing interests exist.

Although the foramen magnum is often described in the context of sex determination, to date, it has not been studied in relation to the Polish population. Considering interpopulation variation of human skull dimensions and shapes, study of a Polish population is needed. The aim of this paper is to evaluate a hierarchy of selected measurements of the foramen magnum in terms of their usefulness for sex determination and provide reference data for Polish non-modern populations in order to propose an alternative method of sex determination for fragmented human remains. Adult skulls from skeletal collection from Poland (N = 101, males 46.5% and females 53.5%) were measured to derive statistical functions. The anteroposterior diameter, transverse diameter, and the circumference of the foramen magnum were found to be significantly larger in males. Mollison's index and discriminant function analysis were performed to derive models for estimation of sex from the foramen magnum measurements and the ± 1 SD ranges of the dimensions were calculated. Each of foramen magnum dimensions was able to predict sex in above 90% of crania. Due to some limitations of this study and the need of population-specific standards, it is recommend employing the foramen magnum in sex determination only in cases of fragmented human remains and when no other method can be applied. Further investigation of possible factors influencing the variability of the foramen magnum size and shape should be conducted in larger and geographically more diverse samples, and this could contribute to forensic, clinical, anatomical, and anthropological studies of this anatomical structure.

Malignant transformation is associated with enhancement of cell plasticity, which allows cancer cells to survive under different conditions by adapting to their microenvironment during growth and metastatic spread. Much effort has been devoted to understanding the molecular mechanisms of these processes. Although the importance of the extracellular matrix and of surface properties in these mechanisms is evident, the direct impact of distinct physical and chemical surfaces characteristics on cell fate remains unclear. Here, we have addressed this question using HT1080 fibrosarcoma cells as a model. To examine the relationship between surface topography, chemistry, and cell behavior, hydrophobic poly(butyl methacrylate-co-ethylene dimethacrylate) (BMA-EDMA) and hydrophilic poly(2-hydroxyethyl methacrylate-co-ethylene dimethacrylate) (HEMA-EDMA) surfaces with three different topographies (microporous, nanoporous, and nonporous) were generated. These surfaces were then modified by photoinitiated grafting of three different methacrylate monomers to create surface chemistry gradients of either negatively (AMPS) or positively (META) charged or zwitterionic (MDSA) functionalities. Our results show that AMPS promotes cell spreading, but that META abolishes cell growth. META and MDSA grafted on microporous BMA-EDMA produced superhydrophilic surfaces with high globularity and elasticity, which modified the cell phenotype by inhibiting cell spreading, followed by loss of mesenchymal characteristics and a reduction in protein levels of the mesenchymal markers N-cadherin, beta-catenin, p120 catenin, and also of the adaptor proteins vinculin and paxillin that are associated with adhesion and cancer cell invasion. The effect was strengthened along the gradient, suggesting that the density of the functional groups plays a role in this process. On the nanoporous surface, only MDSA grafting resulted in a significant increase in cell number, a reduction in N-cadherin expression, increased beta-catenin and p120 catenin levels, as well as the appearance of the epithelial marker E-cadherin. This indicates that the cancer cells have a high plasticity that is triggered by the collaborative effect of physical and chemical surface properties.

Objectives: The aim of this study was to evaluate whether climatic conditions impact the size of the anterior orbital opening in humans. The previous research has shown that morphology of the human orbit, a trait strongly related to the shape of the cranium, varies significantly among populations. However, the mechanisms of this variation are still debatable. Besides such evolutionary forces as genetic drift, climatic conditions may be involved. Thermoregulatory processes affect skull shape, and thus may also influence orbital morphology., Methods: A total of 846 dry skulls of male and female adults from three climatic areas (i.e., warm, temperate, and cold) of Europe were evaluated. The areas of the left and right orbital openings were measured using the three-dimensional contact scanner MicroScribe G2L, and analyzed with regard to climate., Results: The results reveal a statistically significant association with climatic conditions on the area of orbital opening in accordance with Bergmann's rule. The anterior orbital opening area was smaller in male individuals from the cold climate, and larger in individuals from the warm climate areas., Conclusions: These data may support the hypothesized association between size of the orbital opening and adaptation to different climatic conditions, but only in males., (© 2015 Wiley Periodicals, Inc.)

The aim of this study was to provide the morphological and morphometric data of the supraorbital foramina or notches related to sex, side, and the climatic conditions where the population lived. It was hypothesized that the distribution of the occurrence and location of these openings depends on climatic conditions in which the population lived. Orbits from 866 dried skulls obtained from three climatic regions: warm, temperate, and cold were examined. The examination concentrated on the configuration (notch/foramen) and on the distances to the reference points: nasion, frontomalare orbitale, infraorbital foramen and the superior orbital rim. In 14.3% of cases a smooth supraorbital rim was observed while different variants of the structures were observed in 85.7% of the cases. In cold climatic conditions, supraorbital foramina were found in the highest frequency (35.4%). In warm and temperate climates, the observed frequencies of supraorbital foramen were the lowest (18.8% and 19.9%, respectively). Frequency of supraorbital notches was the lowest of those skulls from a cold climate (44.0%) and the highest in those from a warm climate (59.0%). These results support the hypothesis that the occurrence of the supraorbital notches is greater in populations from warm compared with cold regions. This would provide a greater exit route for the neurovascular bundle and this may be related to the thermoregulatory processes in the supraorbital region. Furthermore, knowledge of precise locations of supraorbital structures is important when a supraorbital nerve block is given, for example, in the treatment of migraine headaches., (Copyright © 2012 Wiley Periodicals, Inc.)

Flattening and lowering of the skull base in response to improper bone growth is called platybasis, and is considered a sensitive and reliable indicator of adverse living conditions such as malnutrition and disease during the prenatal period and early childhood. The degree of platybasis was assessed in three series of skulls representing geographically distinct historical native populations from Europe, Australia and Africa. Platybasis was determined by measuring the height of the base of the skull. The degree of platybasis varied among the populations examined, and was the lowest in the Australian group, and the highest in the African group. This may be due to either variability of living conditions or genetic factors, which have an influence on robusticity and cranial architecture. There were also differences among the groups in terms of the other skull measurements and indices examined. The height of the base of the skull was generally greater in males than in females, which indicates sexual dimorphism or fact that females had worse living conditions. Correlation coefficients between the height of the base of the skull and other measurements including skull length and skull width were also calculated indicating significant relationships. The differences between the height of the base of the skull and height/length index and height/width index, were statistically significant.