251. [Effect of calcium antagonists verapamil and amlodipine on the risk of development of atrial fibrillation after coronary artery bypass grafting].
- Author
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Popov SV, Kandinskiĭ ML, Kozlov BN, Antonchenko IV, Evtushenko AV, Dzhavadova GK, Vecherskiĭ IuIu, Akhmedov ShD, Afanas'ev SA, and Shipulin VM
- Subjects
- Adult, Aged, Humans, Male, Middle Aged, Amlodipine adverse effects, Atrial Fibrillation chemically induced, Calcium Channel Blockers adverse effects, Coronary Artery Bypass, Myocardial Ischemia surgery, Postoperative Complications chemically induced, Verapamil adverse effects
- Abstract
Aim: To assess effect of calcium antagonists amlodipine and verapamil on the risk of development of atrial fibrillation after coronary artery bypass surgery., Material: Of 74 patients subjected to mammary artery and venous coronary bypass grafting with the use of cardiopulmonary bypass 19 received amlodipine and 21 - verapamil., Results and Conclusion: Attacks of atrial fibrillation during 24 hour ECG monitoring were registered in 22.9% of patients mostly on days 2 and 3 after surgery. In verapamil treated patients atrial fibrillation occurred 1.5-2 times more often than in amlodipine treated patients or in patients receiving no calcium antagonists. This could possibly be explained by pronounced slowing of atrio-ventricular conduction by verapamil at the background of postoperative general "irritation" of the atrial myocardium.
- Published
- 2003