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3,337 results on '"Kaye, Alan D"'

301. Retraction Note: Gut Microbiome Dysbiosis and Depression: A Comprehensive Review

Author

Capuco, Alexander, primary, Urits, Ivan, additional, Hasoon, Jamal, additional, Chun, Rebecca, additional, Gerald, Brittany, additional, Wang, Jason K., additional, Ngo, Anh L., additional, Simopoulos, Thomas, additional, Kaye, Alan D., additional, Colontonio, Matthew M., additional, Parker-Actlis, Tomasina Q., additional, Fuller, Mitchell C., additional, and Viswanath, Omar, additional

Published
2023
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304. Chronic Administration of Melatonin: Physiological and Clinical Considerations

Author

Givler, Donald, primary, Givler, Amy, additional, Luther, Patrick M., additional, Wenger, Danielle M., additional, Ahmadzadeh, Shahab, additional, Shekoohi, Sahar, additional, Edinoff, Amber N., additional, Dorius, Bradley K., additional, Jean Baptiste, Carlo, additional, Cornett, Elyse M., additional, Kaye, Adam M., additional, and Kaye, Alan D., additional

Published
2023
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307. Updated Perspectives on the Neurobiology of Substance Use Disorders Using Neuroimaging

Author

Murnane,Kevin S, Edinoff,Amber N, Cornett,Elyse M, Kaye,Alan D, Murnane,Kevin S, Edinoff,Amber N, Cornett,Elyse M, and Kaye,Alan D

Abstract

Kevin S Murnane,1 Amber N Edinoff,2 Elyse M Cornett,3 Alan D Kaye3 1Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, USA; 2Department of Psychiatry, Harvard Medical School, Boston, MA, USA; 3Department of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, USACorrespondence: Kevin S Murnane, Louisiana State University Health Sciences Center at Shreveport, 1501 Kings Highway, Shreveport, LA, 71103, USA, Email kevin.murnane@lsuhs.eduAbstract: Substance use problems impair social functioning, academic achievement, and employability. Psychological, biological, social, and environmental factors can contribute to substance use disorders. In recent years, neuroimaging breakthroughs have helped elucidate the mechanisms of substance misuse and its effects on the brain. Functional magnetic resonance imaging (MRI), positron emission tomography (PET), single-photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS) are all examples. Neuroimaging studies suggest substance misuse affects executive function, reward, memory, and stress systems. Recent neuroimaging research attempts have provided clinicians with improved tools to diagnose patients who misuse substances, comprehend the complicated neuroanatomy and neurobiology involved, and devise individually tailored and monitorable treatment regimens for individuals with substance use disorders. This review describes the most recent developments in drug misuse neuroimaging, including the neurobiology of substance use disorders, neuroimaging, and substance use disorders, established neuroimaging techniques, recent developments with established neuroimaging techniques and substance use disorders, and emerging clinical neuroimaging technology.Keywords: MRI, neurobiology, substance misuse, addiction, neuroimaging, AI, PET, fMRI, SPECT

Published
2023

313. Tumor Necrosis Factor and Interleukin Modulators for Pathologic Pain States: A Narrative Review

Author

Kaye, Alan D., Perilloux, Dominique M., Hawkins, Alison M., Wester, Grace C., Ragaland, Amanda R., Hebert, Sage V., Kim, Julian, Heisler, Michael, Kelkar, Rucha A., Chami, Azem A., Shekoohi, Sahar, and Kaye, Adam M.

Abstract

Chronic pain, a complex and debilitating condition, involves intricate interactions between central and peripheral inflammatory processes. Cytokines, specifically tumor necrosis factor (TNF) and interleukins (IL), are key mediators in the initiation and maintenance of chronic pain states. Sensory neurons expressing receptors for cytokines like TNF, IL-1, and IL-6 are implicated in peripheral sensitization, contributing to increased signaling of painful sensations. The potential of targeting TNF and IL for therapeutic intervention in chronic pain states is the focus of this review, with preclinical and clinical evidence supporting the use of TNF and IL modulators for pain management. The physiological and pathological roles of TNF in neuropathic pain is complex. Experimental evidence highlights the effectiveness of TNF modulation in mitigating pain symptoms in animal models and displays promising outcomes of clinical trials with TNF inhibitors, such as infliximab and etanercept. ILs, a diverse group of cytokines, including IL-1, IL-6, and IL-17, are discussed for their contributions to chronic pain through inflammation and peripheral sensitization. Specific IL modulators, such as secukinumab and tocilizumab, have shown potential in managing chronic neuropathic pain, as demonstrated in various studies and clinical trials. The pharmacokinetics, safety profiles, and challenges associated with TNF and IL modulators highlight the need for cautious medication monitoring in clinical practice. Comparative evaluations have revealed distinct efficacy and safety profiles among different cytokine modulators, emphasizing the need for personalized approaches based on the specific underlying causes of pain. Further research is necessary to elucidate the intricate mechanisms by which cytokines contribute to chronic pain, as well as to understand why they may affect pain differently in various contexts. Additionally, long-term safety profiles of cytokine modulators require more thorough investigation. This continued exploration holds the promise of enhancing our comprehension of cytokine modulation in chronic pain and shaping more potent therapeutic strategies for the future.

Published
2024
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315. Thoracic Spine Pain

Author

Jones, Mark R., primary, Novitch, Matthew, additional, Hadley, Graham R., additional, Kaye, Alan D., additional, and Diwan, Sudhir A., additional

Published
2018
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321. Pain Management for General Surgery

Author

Stammen, Katherine, primary, Siddaiah, Harish, additional, Brechtel, Cody, additional, Cornett, Elyse M., additional, Fox, Charles J., additional, and Kaye, Alan D., additional

Published
2018
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