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2,682 results on '"Kangawa, Kenji"'

303. Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells

Author

Kokame Koichi, Minegishi Takashi, Takagi Takeshi, Sinozaki Hiromitsu, Abe Yumiko, Kangawa Kenji, Uesaka Miki, and Miyamoto Kaoru

Subjects
Gynecology and obstetrics, RG1-991, Reproduction, QH471-489
Abstract

Abstract Background Exposure to dioxins results in a broad range of pathophysiological disorders in human fetuses. In order to evaluate the effects of dioxins on the feto-placental tissues, we analyzed the gene expression in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated primary cultures of human amniotic epithelial cells. Methods Human amniotic epithelial cells were dispersed by trypsin from amniotic membranes and cultured in DME/Ham's F12 medium supplemented with 10% FBS. Two weeks after plating, cells were treated with 50 nM TCDD or DMSO (control), further incubated for 48 hrs, and the gene expression was analyzed by DNA microarray technology and quantitative real-time PCR. Results Thirty eight TCDD-inducible genes, including cytochromeP4501A1 and cytochromeP4501B1, were identified. One of the remarkable profiles of the gene expression was the prominent up-regulation of interferon-inducible genes. The genes involved in the interferon gene expression and interferon signaling pathways were also up-regulated. Furthermore, the expression of genes related to collagen synthesis or degradation was enhanced by TCDD. Conclusion Using DNA microarray and quantitative real-time PCR analyses, we identified TCDD-inducible genes, including interferon-inducible genes and genes related to collagen synthesis or degradation, in human amniotic epithelial cells.

Published
2006
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307. Additional file 1: of A multicenter randomized controlled trial of surgery alone or surgery with atrial natriuretic peptide in lung cancer surgery: study protocol for a randomized controlled trial

Author

Nojiri, Takashi, Yamamoto, Haruko, Hamasaki, Toshimitsu, Onda, Kaori, Ohshima, Kikuko, Shintani, Yasushi, Meinoshin Okumura, and Kangawa, Kenji

Abstract

SPIRIT 2013 checklist: recommended items to address in a clinical trial protocol and related documents. (DOC 121Â kb)

Published
2017
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310. Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration

Author

Mitsukawa, Tomohiro, Takemura, Jiro, Asai, Junko, Masamitsu, Nakazato, Kangawa, Kenji, Matsuo, Hisayuki, and Matsukura, Shigeru

Subjects
Pancreas -- Secretions, Pancreatic beta cells -- Physiological aspects, Amyloidosis -- Development and progression, Health, Physiological aspects, Development and progression
Abstract

We determined islet amyloid polypeptide (IAPP) response in plasma to oral and intravenous glucose administration and intravenous insulin injection in nondiabetic subjects. Moreover, we studied the effect of somatostatin analogue [...]

Published
1990

311. A phase II, open-label clinical trial on the combination therapy with medium-chain triglycerides and ghrelin in patients with chronic obstructive pulmonary disease.

Author

Miki, Keisuke, Kitada, Seigo, Miki, Mari, Hui, Shu-Ping, Shrestha, Rojeet, Yoshimura, Kenji, Tsujino, Kazuyuki, Kagawa, Hiroyuki, Oshitani, Yohei, Kida, Hiroshi, Maekura, Ryoji, and Kangawa, Kenji

Abstract

The aim of this study was to investigate the effect of activated ghrelin with dietary octanoic acids or medium-chain triglyceride (MCT) administration to underweight patient with chronic obstructive pulmonary disease (COPD). Eleven severe and very severe COPD patients received a 5-day treatment with edible MCT. Sequentially, 10 patients received a 3-week combination treatment with MCT and intravenous acyl ghrelin. Five-day MCT treatment increased endogenous acyl ghrelin (p = 0.0049), but the total ghrelin level was unchanged. MCT–ghrelin combination treatment improved the peak oxygen uptake (p = 0.0120) during whole treatment course. This effect was attributed to the resultant improvements in cardiac function by O2 pulse, and to the difference between inspired and expired oxygen concentration rather than minute ventilation. Addition of dietary MCT to ghrelin treatment improved the aerobic capacity of underweight COPD patients, likely by mechanisms of increased O2 delivery through improvements in primary cardiocirculatory and muscular crosstalk. [ABSTRACT FROM AUTHOR]

Published
2019
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312. Amniotic Fluid Natriuretic Peptide Levels in Fetuses With Congenital Heart Defects or Arrhythmias

Author

Miyoshi, Takekazu, primary, Hosoda, Hiroshi, additional, Umekawa, Takashi, additional, Asada, Takashi, additional, Fujiwara, Akihiro, additional, Kurosaki, Ken-ichi, additional, Shiraishi, Isao, additional, Nakai, Michikazu, additional, Nishimura, Kunihiro, additional, Miyazato, Mikiya, additional, Kangawa, Kenji, additional, Ikeda, Tomoaki, additional, Yoshimatsu, Jun, additional, and Minamino, Naoto, additional

Published
2018
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315. Guanylyl Cyclase A in Both Renal Proximal Tubular and Vascular Endothelial Cells Protects the Kidney against Acute Injury in Rodent Experimental Endotoxemia Models

Author

Kitamura, Hiroaki, primary, Nakano, Daisuke, additional, Sawanobori, Yoshiharu, additional, Asaga, Takehiko, additional, Yokoi, Hideki, additional, Yanagita, Motoko, additional, Mukoyama, Masashi, additional, Tokudome, Takeshi, additional, Kangawa, Kenji, additional, Shirakami, Gotaro, additional, and Nishiyama, Akira, additional

Published
2018
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316. Angiotensin II promotes pulmonary metastasis of melanoma through the activation of adhesion molecules in vascular endothelial cells

Author

Ishikane, Shin, primary, Hosoda, Hiroshi, additional, Nojiri, Takashi, additional, Tokudome, Takeshi, additional, Mizutani, Tetsuya, additional, Miura, Koichi, additional, Akitake, Yoshiharu, additional, Kimura, Toru, additional, Imamichi, Yoshitaka, additional, Kawabe, Shinya, additional, Toyohira, Yumiko, additional, Yanagihara, Nobuyuki, additional, Takahashi-Yanaga, Fumi, additional, Miyazato, Mikiya, additional, Miyamoto, Kaoru, additional, and Kangawa, Kenji, additional

Published
2018
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317. Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure

Author

Takahama, Hiroyuki, primary, Takashio, Seiji, additional, Nishikimi, Toshio, additional, Hayashi, Tomohiro, additional, Nagai-Okatani, Chiaki, additional, Nakagawa, Yasuaki, additional, Amaki, Makoto, additional, Ohara, Takahiro, additional, Hasegawa, Takuya, additional, Sugano, Yasuo, additional, Kanzaki, Hideaki, additional, Yasuda, Satoshi, additional, Kangawa, Kenji, additional, Minamino, Naoto, additional, and Anzai, Toshihisa, additional

Published
2018
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324. Effectiveness of nationwide screening and lifestyle intervention for abdominal obesity and cardiometabolic risks in Japan: The metabolic syndrome and comprehensive lifestyle intervention study on nationwide database in Japan (MetS ACTION-J study)

Author

Nakao, Yoko M., primary, Miyamoto, Yoshihiro, additional, Ueshima, Kenji, additional, Nakao, Kazuhiro, additional, Nakai, Michikazu, additional, Nishimura, Kunihiro, additional, Yasuno, Shinji, additional, Hosoda, Kiminori, additional, Ogawa, Yoshihiro, additional, Itoh, Hiroshi, additional, Ogawa, Hisao, additional, Kangawa, Kenji, additional, and Nakao, Kazuwa, additional

Published
2018
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325. Angiotensin II increase the pulmonary metastasis through the vascular endothelial cell adherent pathway in hematogenous metastasis of melanoma cells

Author

Ishikane, Shin, primary, Hosoda, Hiroshi, additional, Nojiri, Takashi, additional, Tokudome, Takeshi, additional, Mizutani, Tetsuya, additional, Toyohira, Yumiko, additional, Miyazato, Mikiya, additional, Miyamoto, Kaoru, additional, Kangawa, Kenji, additional, and Takahashi-Yanaga, Fumi, additional

Published
2018
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326. Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice

Author

Teranishi, Hitoshi, primary, Hayashi, Masafumi, additional, Higa, Ryoko, additional, Mori, Kenji, additional, Miyazawa, Takashi, additional, Hino, Jun, additional, Amano, Yuichiro, additional, Tozawa, Ryuichi, additional, Ida, Takanori, additional, Hanada, Toshikatsu, additional, Miyazato, Mikiya, additional, Hanada, Reiko, additional, Kangawa, Kenji, additional, and Nakao, Kazuwa, additional

Published
2018
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335. Plasma brain natriuretic peptide levels are elevated in patients with cancer

Author

Bando, Sachiko, Soeki, Takeshi, Matsuura, Tomomi, Tobiume, Takeshi, Ise, Takayuki, Kusunose, Kenya, Yamaguchi, Koji, Yagi, Shusuke, Fukuda, Daiju, Iwase, Takashi, Yamada, Hirotsugu, Wakatsuki, Tetsuzo, Shimabukuro, Michio, Muguruma, Naoki, Takayama, Tetsuji, Kishimoto, Ichiro, Kangawa, Kenji, Sata, Masataka, Bando, Sachiko, Soeki, Takeshi, Matsuura, Tomomi, Tobiume, Takeshi, Ise, Takayuki, Kusunose, Kenya, Yamaguchi, Koji, Yagi, Shusuke, Fukuda, Daiju, Iwase, Takashi, Yamada, Hirotsugu, Wakatsuki, Tetsuzo, Shimabukuro, Michio, Muguruma, Naoki, Takayama, Tetsuji, Kishimoto, Ichiro, Kangawa, Kenji, and Sata, Masataka

Abstract

Background Natriuretic peptides have been proposed as biomarkers of cardiovascular disease, especially heart failure. Brain natriuretic peptide (BNP) has also been shown to be upregulated at the transcriptional and translational levels by pro-inflammatory cytokines in cardiac myocytes. Although we often measure plasma BNP levels in cancer patients, it remains unknown whether cancer-related inflammation affects the plasma BNP levels. We investigated the relationship between the BNP and human cancers. Methods We retrospectively studied 2,923 patients in whom the plasma BNP levels and serum C-reactive protein (CRP) were measured and echocardiography was performed. Patients with clinically evident heart failure (NYHA II or higher), heart disease requiring medical treatment or surgery, renal dysfunction, and inflammatory disease were excluded. There were 234 patients in the final analysis. Blood sampling was performed before surgery and chemotherapy. In addition, we evaluated the relationship between the inflammation and plasma BNP levels in mouse models of colon cancer. Results Of the 234 patients, 80 were diagnosed with cancer. Both the plasma BNP and serum CRP levels were significantly higher in cancer patients than those without. There were no significant differences in the echocardiographic parameters. There was a significant positive correlation between the plasma BNP and serum CRP levels in cancer patients (r = 0.360, P<0.01) but not in those without. In cancer patients, only the CRP correlated with the BNP independent of the age, creatinine level, hypertension, and body mass index. In addition, in nude mice with subcutaneous colon cancer, the plasma BNP level was elevated compared with that in non-cancer mice, and there was a significant relationship between the plasma BNP and serum levels of the inflammatory markers. Conclusions In cancer patients, as well as colon cancer model mice, the plasma BNP levels were elevated, possibly due to cancer-related inflammatio

Published
2017

339. The physiological significance and potential clinical applications of ghrelin

Author

Akamizu, Takashi and Kangawa, Kenji

Subjects
GH deficiency, Clinical trial, Cachexia, Gastrectomy, digestive, oral, and skin physiology, Anorexia nervosa, hormones, hormone substitutes, and hormone antagonists, Ghrelin
Abstract

Ghrelin, a natural ligand for the growth hormone (GH)-secretagogue receptor (GHS-R), is now known to play a role in a number of different physiological processes. For example, ghrelin increases GH secretion, feeding, and body weight when administered centrally or peripherally. These unique effects of ghrelin should be invaluable for the development of novel treatments and disease diagnostic techniques. Clinical trials have already been performed to assess the utility of ghrelin for the treatment of several disorders including anorexia, cachexia, and GH-related disorders. This review summarizes the recent advances in this area of research.

Published
2012

342. Ghrelin protects against bleomycin-induced pulmonary fibrosis in mice

Author

Kyomoto, Yohkoh, primary, Nojiri, Takashi, additional, Tokudome, Takeshi, additional, Kumazoe, Motofumi, additional, Miura, Koichi, additional, Hosoda, Hiroshi, additional, Hino, Jun, additional, Miyazato, Mikiya, additional, Kojima, Kazuya, additional, Kubo, Hiroaki, additional, Okamoto, Atsuko, additional, Yamada, Kazuhiro, additional, Watanabe, Tetsuya, additional, Asai, Kazuhisa, additional, Hirata, Kazuto, additional, and Kangawa, Kenji, additional

Published
2017
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343. Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity

Author

Bae, Cho-Rong, primary, Hino, Jun, additional, Hosoda, Hiroshi, additional, Arai, Yuji, additional, Son, Cheol, additional, Makino, Hisashi, additional, Tokudome, Takeshi, additional, Tomita, Tsutomu, additional, Kimura, Toru, additional, Nojiri, Takashi, additional, Hosoda, Kiminori, additional, Miyazato, Mikiya, additional, and Kangawa, Kenji, additional

Published
2017
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344. Correction for Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability

Author

Takayama, Kentaro, primary, Mori, Kenji, additional, Tanaka, Akiko, additional, Nomura, Erina, additional, Sohma, Yuko, additional, Mori, Miwa, additional, Taguchi, Akihiro, additional, Taniguchi, Atsuhiko, additional, Sakane, Toshiyasu, additional, Yamamoto, Akira, additional, Minamino, Naoto, additional, Miyazato, Mikiya, additional, Kangawa, Kenji, additional, and Hayashi, Yoshio, additional

Published
2017
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345. Discovery of a Human Neuromedin U Receptor 1-Selective Hexapeptide Agonist with Enhanced Serum Stability

Author

Takayama, Kentaro, primary, Mori, Kenji, additional, Tanaka, Akiko, additional, Nomura, Erina, additional, Sohma, Yuko, additional, Mori, Miwa, additional, Taguchi, Akihiro, additional, Taniguchi, Atsuhiko, additional, Sakane, Toshiyasu, additional, Yamamoto, Akira, additional, Minamino, Naoto, additional, Miyazato, Mikiya, additional, Kangawa, Kenji, additional, and Hayashi, Yoshio, additional

Published
2017
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346. Plasma brain natriuretic peptide levels are elevated in patients with cancer

Author

Bando, Sachiko, primary, Soeki, Takeshi, additional, Matsuura, Tomomi, additional, Tobiume, Takeshi, additional, Ise, Takayuki, additional, Kusunose, Kenya, additional, Yamaguchi, Koji, additional, Yagi, Shusuke, additional, Fukuda, Daiju, additional, Iwase, Takashi, additional, Yamada, Hirotsugu, additional, Wakatsuki, Tetsuzo, additional, Shimabukuro, Michio, additional, Muguruma, Naoki, additional, Takayama, Tetsuji, additional, Kishimoto, Ichiro, additional, Kangawa, Kenji, additional, and Sata, Masataka, additional

Published
2017
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347. The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma

Author

Kumazoe, Motofumi, primary, Takai, Mika, additional, Hiroi, Shun, additional, Takeuchi, Chieri, additional, Kadomatsu, Mai, additional, Nojiri, Takashi, additional, Onda, Hiroaki, additional, Bae, Jaehoon, additional, Huang, Yuhui, additional, Takamatsu, Kanako, additional, Yamashita, Shuya, additional, Kangawa, Kenji, additional, and Tachibana, Hirofumi, additional

Published
2017
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348. Transcriptome analysis reveals a role for the endothelial ANP-GC-A signaling in interfering with pre-metastatic niche formation by solid cancers

Author

Nojiri, Takashi, primary, Arai, Miki, additional, Suzuki, Yutaka, additional, Kumazoe, Motofumi, additional, Tokudome, Takeshi, additional, Miura, Koichi, additional, Hino, Jun, additional, Hosoda, Hiroshi, additional, Miyazato, Mikiya, additional, Okumura, Meinoshin, additional, Kawaoka, Shinpei, additional, and Kangawa, Kenji, additional

Published
2017
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350. PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma

Author

Kumazoe, Motofumi, primary, Takai, Mika, additional, Hiroi, Shun, additional, Takeuchi, Chieri, additional, Yamanouchi, Maasa, additional, Nojiri, Takashi, additional, Onda, Hiroaki, additional, Bae, Jaehoon, additional, Huang, Yuhui, additional, Takamatsu, Kanako, additional, Yamashita, Shuya, additional, Yamada, Shuhei, additional, Kangawa, Kenji, additional, Takahashi, Takashi, additional, Tanaka, Hiroshi, additional, and Tachibana, Hirofumi, additional

Published
2017
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