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125 results on '"Kanao, Kent"'

101. MP77-19 THE PREDICTIVE VALUE OF C-REACTIVE PROTEIN FOR PROGNOSIS IN PATIENTS WITH METASTATIC UPPER TRACT UROTHELIAL CARCINOMA TREATED WITH CISPLATIN-BASED CHEMOTHERAPY FOLLOWING RADICAL NEPHROURETERECTOMY: MULTI-INSTITUTIONAL STUDY

Author

Obata, Jun, primary, Kikuchi, Eiji, additional, Tanaka, Nobuyuki, additional, Shirotake, Suguru, additional, Matsumoto, Kazuhiro, additional, Oyama, Masahumi, additional, Kanao, Kent, additional, Kobayashi, Hiroaki, additional, Miyazaki, Yasumasa, additional, Ide, Hiroki, additional, Ishioka, Katsura, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakagawa, Ken, additional, and Oya, Mototsugu, additional

Published
2014
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103. The Predictive Value of C-reactive Protein for Prognosis in Patients with Upper Tract Urothelial Carcinoma Treated with Radical Nephroureterectomy: A Multi-institutional Study

Author

Tanaka, Nobuyuki, primary, Kikuchi, Eiji, additional, Shirotake, Suguru, additional, Kanao, Kent, additional, Matsumoto, Kazuhiro, additional, Kobayashi, Hiroaki, additional, Miyazaki, Yasumasa, additional, Ide, Hiroki, additional, Obata, Jun, additional, Hoshino, Katsura, additional, Hayakawa, Nozomi, additional, Ito, Yujiro, additional, Kosaka, Takeo, additional, Kodaira, Kiichiro, additional, Oyama, Masafumi, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakagawa, Ken, additional, Ueno, Munehisa, additional, and Oya, Mototsugu, additional

Published
2014
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104. Metastatic Behavior of Upper Tract Urothelial Carcinoma After Radical Nephroureterectomy: Association with Primary Tumor Location

Author

Tanaka, Nobuyuki, primary, Kikuchi, Eiji, additional, Kanao, Kent, additional, Matsumoto, Kazuhiro, additional, Kobayashi, Hiroaki, additional, Ide, Hiroki, additional, Miyazaki, Yasumasa, additional, Obata, Jun, additional, Hoshino, Katsura, additional, Shirotake, Suguru, additional, Akita, Hirotaka, additional, Kosaka, Takeo, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakagawa, Ken, additional, Hasegawa, Shintaro, additional, Nakajima, Yosuke, additional, Jinzaki, Masahiro, additional, and Oya, Mototsugu, additional

Published
2013
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105. Prognostic value of preoperative multiparametric magnetic resonance imaging (MRI) for predicting biochemical recurrence after radical prostatectomy

Author

Hattori, Seiya, primary, Kosaka, Takeo, additional, Mizuno, Ryuichi, additional, Kanao, Kent, additional, Miyajima, Akira, additional, Yasumizu, Yota, additional, Yazawa, Satoshi, additional, Nagata, Hirohiko, additional, Kikuchi, Eiji, additional, Mikami, Shuji, additional, Jinzaki, Masahiro, additional, Nakagawa, Ken, additional, Tanimoto, Akihiro, additional, and Oya, Mototsugu, additional

Published
2013
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106. 398 CHARACTERISTICS AND OUTCOME IN METASTATIC UPPER TRACT UROTHELIAL CARCINOMA FOLLOWING RADICAL NEPHROURETERECTOMY: THE MULTI-INSTITUTIONAL EXPERIENCE

Author

Tanaka, Nobuyuki, primary, Kikuchi, Eiji, additional, Shirotake, Suguru, additional, Matsumoto, Kazuhiro, additional, Kobayashi, Hiroaki, additional, Miyazaki, Yasumasa, additional, Ide, Hiroki, additional, Obata, Jun, additional, Hoshino, Katsura, additional, Kosaka, Takeo, additional, Kanao, Kent, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakagawa, Ken, additional, Nakajima, Yosuke, additional, Hasegawa, Shintaro, additional, and Oya, Mototsugu, additional

Published
2013
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107. 697 C-REACTIVE PROTEIN INDEPENDENTLY PREDICTS THE PROGNOSIS OF PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA TREATED WITH RADICAL NEPHROURETERECTOMY: A MULTI-INSTITUTIONAL STUDY

Author

Obata, Jun, primary, Kikuchi, Eiji, additional, Tanaka, Nobuyuki, additional, Ishioka, Katsura, additional, Shirotake, Suguru, additional, Matsumoto, Kazuhiro, additional, Kobayashi, Hiroaki, additional, Miyazaki, Yasumasa, additional, Ide, Hiroki, additional, Hayakawa, Nozomi, additional, Ito, Yujiro, additional, Kanao, Kent, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakagawa, Ken, additional, Ueno, Munehisa, additional, and Oya, Mototsugu, additional

Published
2013
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108. 399 PREDICTIVE VALUE OF POSITIVE URINE CYTOLOGY FOR PROGNOSIS IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA FOLLOWING RADICAL NEPHROURETERECTOMY

Author

Tanaka, Nobuyuki, primary, Kikuchi, Eiji, additional, Miyazaki, Yasumasa, additional, Shirotake, Suguru, additional, Kobayashi, Hiroaki, additional, Matsumoto, Kazuhiro, additional, Ide, Hiroki, additional, Obata, Jun, additional, Hoshino, Katsura, additional, Kosaka, Takeo, additional, Kanao, Kent, additional, Oyama, Masafumi, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakagawa, Ken, additional, Nakajima, Yosuke, additional, and Oya, Mototsugu, additional

Published
2013
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109. 1165 NOVEL ALGORITHM FOR PREDICTING SEVERE CASES OF ACUTE BACTERIAL PROSTATITIS

Author

Yazawa, Satoshi, primary, Nagata, Hirohiko, additional, Kanao, Kent, additional, Kikuchi, Eiji, additional, Hosokawa, Naoto, additional, Hongo, Shu, additional, Ohji, Goh, additional, Morita, Shinya, additional, Kosaka, Takeo, additional, Kono, Hidaka, additional, Mizuno, Ryuichi, additional, Asanuma, Hiroshi, additional, Miyajima, Akira, additional, Nakagawa, Ken, additional, Tanoguchi, Hitoshi, additional, Nakajima, Yosuke, additional, and Oya, Mototsugu, additional

Published
2013
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110. 681 THE DISTINCT ASSOCIATION BETWEEN PRIMARY TUMOR LOCATION AND THE PATTERNS OF METASTATIC SPREAD FOLLOWING RADICAL NEPHROURETERECTOMY IN PATIENTS WITH UPPER TRACT UROTHELIAL CARCINOMA

Author

Tanaka, Nobuyuki, primary, Kikuchi, Eiji, additional, Kanao, Kent, additional, Matsumoto, Kazuhiro, additional, Kobayashi, Hiroaki, additional, Ide, Hiroki, additional, Miyazaki, Yasumasa, additional, Obata, Jun, additional, Hoshino, Katsura, additional, Shirotake, Suguru, additional, Kosaka, Takeo, additional, Miyajima, Akira, additional, Momma, Tetsuo, additional, Nakajima, Yosuke, additional, Hasegawa, Shintaro, additional, Nakagawa, Ken, additional, Jinzaki, Masahiro, additional, and Oya, Mototsugu, additional

Published
2013
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112. Performance Characteristics of MR Imaging in the Evaluation of Clinically Low-Risk Prostate Cancer: A Prospective Study

Author

Vargas, Hebert Alberto, primary, Akin, Oguz, additional, Shukla-Dave, Amita, additional, Zhang, Jingbo, additional, Zakian, Kristen L., additional, Zheng, Junting, additional, Kanao, Kent, additional, Goldman, Debra A., additional, Moskowitz, Chaya S., additional, Reuter, Victor E., additional, Eastham, James A., additional, Scardino, Peter T., additional, and Hricak, Hedvig, additional

Published
2012
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122. The predictive value of positive urine cytology for outcomes following radical nephroureterectomy in patients with primary upper tract urothelial carcinoma: A multi-institutional study 1 [1] This work was supported in part by Grants-in-Aid for Scientific Research (#24791671 to Tanaka N.) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.

Author

Tanaka, Nobuyuki, Kikuchi, Eiji, Kanao, Kent, Matsumoto, Kazuhiro, Shirotake, Suguru, Kobayashi, Hiroaki, Miyazaki, Yasumasa, Ide, Hiroki, Obata, Jun, Hoshino, Katsura, Hayakawa, Nozomi, Kosaka, Takeo, Oyama, Masafumi, Miyajima, Akira, Momma, Tetsuo, Nakagawa, Ken, Jinzaki, Masahiro, Nakajima, Yosuke, and Oya, Mototsugu

Subjects
*NEPHRECTOMY, *TRANSITIONAL cell carcinoma, *CYTOLOGY, *URINARY organ cancer, *METASTASIS, *CANCER relapse, *PATIENTS, *THERAPEUTICS
Abstract

Abstract: Background and objective: Few studies have addressed the predictive value of positive urine cytology for prognosis in patients with upper tract urothelial carcinoma (UTUC). We investigated whether the status of preoperative urine cytology could provide additional prognostic information following radical nephroureterectomy (RNU). Materials and methods: The study included 474 patients with primary nonmetastatic UTUC (pTa-4N0M0) from a retrospective multi-institutional cohort. The median follow-up period was 35 months. Associations between the status of urine cytologic evaluation and outcomes were analyzed using multivariate Cox regression models. Urine cytology was evaluated preoperatively using voided samples. Disease recurrence was defined as any relapse in nonbladder lesions and was coded separately from intravesical recurrence. Results: Positive urine cytology was detected in 184 patients (38.8%) preoperatively. Disease recurrence occurred in 127 patients, while intravesical recurrence occurred in 219 patients; 83 patients died of UTUC during follow-up. Kaplan-Meier analysis revealed that only the incidence of intravesical recurrence was significantly associated with the status of urine cytologic evaluation (P = 0.024); the intravesical recurrence-free survival rates at 1 and 3 years following RNU were 61.4% and 46.2% in patients with positive urine cytology and 71.1% and 51.6% in their counterparts, respectively. Multivariate analysis showed that gender (hazard ratio [HR] = 1.74, 95% confidence interval [CI]; 1.28–2.43), tumor multifocality in RNU specimens (HR = 1.64, 95% CI; 1.09–2.47), and positive urine cytology (HR = 1.41, 95% CI; 1.08–1.85) were independent risk factors for subsequent intravesical recurrence. Conclusions: The results showed the prognostic value of positive urine cytology in patients with primary UTUC, and preoperative positive urine cytology may be associated with a significant increase in the prevalence of intravesical recurrence following RNU. [Copyright &y& Elsevier]

Published
2014
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123. New risk stratification for adjuvant nivolumab for high-risk muscle-invasive urothelial carcinoma.

Author

Saito T, Kanao K, Matsumoto K, Fukumoto K, Igarashi D, Takahashi T, Kaneko G, Shirotake S, Nishimoto K, Mizuno R, Ishida M, Hara S, Oya M, and Oyama M

Abstract

Objectives: We aim to evaluate the risk of recurrence after neoadjuvant chemotherapy followed by radical cystectomy, particularly in ypT2 disease in patients with urothelial carcinoma, because it is not clear if all eligible patients with high-risk muscle-invasive urothelial carcinoma should be treated with adjuvant nivolumab., Materials and Methods: We analysed the radiological and clinicopathological features, including cT and ypT stages, of 197 patients who had undergone two to four cycles of cisplatin-based neoadjuvant chemotherapy and radical cystectomy without adjuvant chemotherapy. We stratified the risk of postoperative recurrence by these factors., Results: The median observation period was 29.6 (interquartile range, 11.4-71.7) months, and disease recurrence was observed in 58 patients. Multivariate analysis revealed that ypT stage ( P  = 0.019) and lymphovascular invasion ( P  = 0.015) were independent risk factors for postoperative recurrence. The ypT2 group ( n  = 38) had significantly better recurrence-free survival than the ypT3 group ( n  = 41) (median recurrence-free survival: not reached vs. 13.4 months, respectively, P  = 0.005). In ypT2 disease, the cT2 and ypT2 group ( n  = 15), which was diagnosed as cT2 preoperatively and then diagnosed as ypT2 postoperatively, had significantly better recurrence-free survival than the cT3/4 and ypT2 group ( n  = 23) (median recurrence-free survival: not reached vs. 63.1 months, respectively, P  = 0.034). There was no significant difference in recurrence-free survival between the ypT ≤ 1 ( n  = 106) and the cT2 and ypT2 groups (median recurrence-free survival: not reached in both, P  = 0.962)., Conclusion: Patients with cT2 and ypT2 stage have a relatively low risk of recurrence and thus have a lower need for adjuvant nivolumab, particularly those with ypT2., Competing Interests: All authors have no conflict of interest to disclose., (© 2023 The Authors. BJUI Compass published by John Wiley & Sons Ltd on behalf of BJU International Company.)

Published
2023
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124. [A case of neuroendocrine carcinoma in a diverticulum of the bladder].

Author

Muramatsu H, Kanao K, Morinaga S, Kajikawa K, Kobayashi I, Nishikawa G, Yoshizawa T, Kato Y, Watanabe M, Zennami K, Nakamura K, and Sumitomo M

Subjects
Aged, Cystectomy, Diverticulum surgery, Female, Humans, Magnetic Resonance Imaging, Neoplasm Invasiveness, Urinary Bladder Neoplasms surgery, Carcinoma, Neuroendocrine surgery, Diverticulum pathology, Urinary Bladder Neoplasms pathology
Abstract

We report a case of neuroendocrine carcinoma in a diverticulum of the bladder. A 65-year-old Japanese woman visited our hospital with the chief complaint of gross hematuria. Cystoscopy revealed a non-papillary broad-based tumor in a diverticulum of the posterior wall. She underwent transurethral resection of bladder tumor (TURBT) and subsequently total cystectomy with ileal conduit on the diagnosis of an invasive urothelial carcinoma. There was no residual tumor in the surgical specimen. Immunohistochemistry of TUR specimens showed positive synaptophysin, chromogranin A, CD56 and high ratio of positive Ki-67. Finally, it was diagnosed as a neuroendocrine carcinoma of the bladder. To our knowledge, this is the second case report of the neuroendocrine tumor or small cell carcinoma in a diverticulum of the urinary bladder in the Japanese literature.

Published
2014

125. Prevention of cancer cachexia by a novel nuclear factor {kappa}B inhibitor in prostate cancer.

Author

Kuroda K, Horiguchi Y, Nakashima J, Kikuchi E, Kanao K, Miyajima A, Ohigashi T, Umezawa K, and Murai M

Subjects
Albumins metabolism, Animals, Antineoplastic Agents pharmacology, Benzamides chemistry, Body Mass Index, Body Weight, Cell Line, Tumor, Cyclohexanones chemistry, Disease Models, Animal, Dose-Response Relationship, Drug, Hematocrit, Humans, Interleukin-6 biosynthesis, Interleukin-6 blood, Interleukin-6 metabolism, Male, Mice, Mice, Inbred BALB C, Muscle, Skeletal drug effects, Neoplasm Transplantation, Time Factors, Triglycerides blood, Weight Loss drug effects, Benzamides pharmacology, Cachexia prevention & control, Cyclohexanones pharmacology, NF-kappa B antagonists & inhibitors, Prostatic Neoplasms complications, Prostatic Neoplasms drug therapy
Abstract

Purpose: To investigate the association between serum interleukin-6 (IL-6) and cachexia in patients with prostate cancer and the inhibitory effect of a new nuclear factor kappaB (NF-kappaB) inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on IL-6 production and cachexia in an animal model of hormone-refractory prostate cancer., Experimental Design: The association between serum IL-6 levels and variables of cachexia was evaluated in 98 patients with prostate cancer. The inhibitory effects of DHMEQ on IL-6 secretion and cachexia were investigated in in vitro and in vivo studies using JCA-1 cells derived from human prostate cancer., Results: Serum IL-6 levels were significantly elevated and cachexia developed in JCA-1 tumor-bearing mice as well as in prostate cancer patients with progressive disease. IL-6 secretion was significantly inhibited in JCA-1 cells exposed to DHMEQ. Intraperitoneal administration of DHMEQ (8 mg/kg) to tumor-bearing mice produced a significant amelioration of the reduction in body weight, epididymal fat weight, gastrocnemius muscle weight, hematocrit, and serum levels of triglyceride and albumin when compared with administration of DMSO or no treatment. DHMEQ caused a significant decrease of serum IL-6 level in JCA-1 tumor-bearing mice (all P < 0.05)., Conclusions: These results suggested an association between serum IL-6 and cachexia in patients with prostate cancer and in JCA-1 tumor-bearing mice and that a new NF-kappaB inhibitor, DHMEQ, could prevent the development of cachexia in JCA-1 tumor-bearing mice presumably through the inhibition of IL-6 secretion. DHMEQ seems to show promise as a novel and unique anticachectic agent in hormone-refractory prostate cancer.

Published
2005
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