301. TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: An open label study
- Author
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Chi Un Pae, Antonio Drago, In Ho Paik, Diana De Ronchi, Tae Youn Jun, Chul Lee, Jung-Jin Kim, Ashwin A. Patkar, Alessandro Serretti, Laura Mandelli, Pae C.-U., Drago A., Kim J.-J., Patkar A.A., Jun T.-Y., Lee C., Mandelli L., De Ronchi D., Paik I.-H., and Serretti A.
- Subjects
Adult ,Male ,medicine.medical_specialty ,Psychosis ,Single-nucleotide polymorphism ,Cell Cycle Proteins ,Polymorphism, Single Nucleotide ,Genetic determinism ,Receptors, G-Protein-Coupled ,TAAR6 ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Internal medicine ,Schizophrenic Psychology ,medicine ,Humans ,Young adult ,Psychiatry ,Alleles ,Psychiatric Status Rating Scales ,Korea ,business.industry ,Haplotype ,Homozygote ,Nuclear Proteins ,Middle Aged ,medicine.disease ,Prognosis ,030227 psychiatry ,Psychiatry and Mental health ,Treatment Outcome ,Haplotypes ,Schizophrenia ,Female ,business ,030217 neurology & neurosurgery ,Antipsychotic Agents - Abstract
We recently reported an association betweenTAAR6(trace amine associated receptor 6 gene) variations and schizophrenia (SZ). We now report an association of a set ofTAAR6variations and clinical presentation and outcome in a sample of 240 SZ Korean patients. Patients were selected by a Structured Clinical Interview, DSM-IV Axis I disorders – Clinical Version (SCID-CV). Other psychiatric or neurologic disorders, as well as medical diseases, were exclusion criteria. To assess symptom severity, patients were administered the CGI scale and the PANSS at baseline and at the moment of discharge, 1 month later on average.TAAR6variations rs6903874, rs7452939, rs8192625 and rs4305745 were investigated; rs6903874, rs7452939 and rs8192625 entered the statistical investigation after LD analysis. Rs8192625 G/G homozygosis was found to be significantly associated both with a worse clinical presentation at PANSS total and positive scores and with a shorter period of illness before hospitalization. No haplotype significant findings were found. The present study stands for a role of theTAAR6in the clinical presentation of SZ. Moreover, our results show that this genetic effect may be counteracted by a correct treatment. Haplotype analysis was not informative in our sample, probably also because of the incomplete SNPs' coverage of the gene we performed. Further studies in this direction are warranted.
- Published
- 2008