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301. Emerging effects of early environmental factors over genetic background for type diabetes suscetibility: Evidence from a nationwide Italian twin study

Author

Nisticò L, Iafusco D, GalderisiA, Fagnani C, Cotichini R, Toccarelli V, Stazi MA, Cherubini V, Iannilli A, Paparusso AM, Cavallo L, Zecchino C, De Filippo G, Gargantini L, Salardi S, Zucchini S, Maltoni G, Pasquino B, Kaufmann P, Buzi F, Prandi E, Bonfanti R, Nisticò, L, Iafusco, D, Galderisia, Fagnani, C, Cotichini, R, Toccarelli, V, Stazi, Ma, Cherubini, V, Iannilli, A, Paparusso, Am, Cavallo, L, Zecchino, C, De Filippo, G, Gargantini, L, Salardi, S, Zucchini, S, Maltoni, G, Pasquino, B, Kaufmann, P, Buzi, F, Prandi, E, Bonfanti, R, and Et, Al.

Published
2012

302. New Data on the Genus Niphargus (Amphipoda, Niphargidae) in Italy, with the Description of a New Species of the Orcinus Group

Author

Valentina Iannilli and Augusto Vigna Taglianti

Subjects
Carcinology, Amphipoda, biology, Genus, Ecology, Group (stratigraphy), Species group, Niphargidae, Zoology, Animal Science and Zoology, Aquatic Science, biology.organism_classification, Niphargus
Abstract

The Italian species of Niphargus belonging to the orcinus group are discussed and Niphargus cornicolanus n. sp. (from the Merro sinkhole, Sant'Angelo Romano, Cornicolani Mountains, Latium) is described. This species is morphologically well characterized (Ruffo & Vigna Taglianti, 1968). It is easily distinguished from N. parenzani (from the Alburni Mountains, Campania), to which it had been attributed (G. Karaman, 1993), and from N. patrizii (from the Ausoni and Lepini Mountains, Latium), mainly by the shape of Gn2. The distribution and relationships of the orcinus species group are discussed.

Published
2004
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303. Type 1 diabetes and measles, mumps and rubella childhood infections within the Italian Insulin-dependent Diabetes Registry

Author

Ramondetti, F, Sacco, S., Comelli, M., Bruno, Graziella, Falorni, A, Iannilli, A., D'Annunzio, G., Iafusco, D., Songini, M., Toni, S., Cherubini, V., Carle, F., Cerutti, Franco, Novelli, Giulia, Bianchi, L., Piffer, S., Lorini, R., Minuto, N., Roncarolo, F., Tenconi, M. T., Predieri, B., Reali, M. F., Medici, A., Biagioni, M., Gesuita, R., Santeusanio, F., De Giorgi, G., Visalli, N., Bizzarri, C., Chiarelli, F., Tumini, S., Prisco, F., Confetto, S., Frongia, P., Marinaro, A. M., Ramondetti, F, Sacco, S, Comelli, M, Bruno, G, Falorni, A, Iannilli, A, D'Annunzio, G, Iafusco, Dario, Songini, M, Toni, S, Cherubini, V, and Carle, F.

Subjects
Registrie, Male, Mump, Type 1 diabete, Adolescent, incidenza, association study, infectious diseases, Antibodies, Viral, Diabete mellito di tipo 1, Body Mass Index, children, Measle, Humans, Registries, epidemiologia, association study, children, infectious diseases, Type 1 diabetes, Child, Mumps, Rubella, Infectious disease, Incidence, Infant, Newborn, Infant, Association study, Children, Infectious diseases, Type 1 diabetes, Diabetes Mellitus, Type 1, Italy, Child, Preschool, Female, malattie infettive dell'infanzia, Measles-Mumps-Rubella Vaccine, Human, Measles
Abstract

Diabet. Med. 29, 761-766 (2012) ABSTRACT: Aims Several studies confirmed the growing rate of Type 1 diabetes mellitus in childhood coinciding with increasing diagnosis of viral infections. A study investigating the incidence of Type 1 diabetes during 1996-1997 showed a higher notification of viral infections in the Pavia District. The aim was to confirm these results. Methods This study evaluated the relationship between new cases of Type 1 diabetes and those of measles, mumps and rubella in 1996-2001, analysing data of newly-diagnosed Type 1 diabetes children, aged 0-14 years and enrolled into the RIDI (Italian Insulin-dependent Diabetes Registry) during the same years. Measles, rubella and mumps rates were calculated using as denominator the estimated 'population at risk', represented by the number of 0- to 14 year-old subjects who did not undergo the MMR (measles, mumps and rubella) vaccination. In order to investigate the association between Type 1 diabetes incidence and measles, rubella and mumps respectively, Spearman's rank correlation was used. Results The analysis of the whole Registries data did not at first show any statistical significance between age-standardized Type 1 diabetes incidence density and estimated rates of measles, mumps and rubella notifications. Excluding data from Sardinia Registry, a significant association was observed between Type 1 diabetes incidence and mumps (P = 0.034) and rubella (P = 0.014), respectively, while there was no statistical significance between the incidence of measles cases and diabetes rates (P = 0.269). Conclusions According to our findings, mumps and rubella viral infections are associated with the onset of Type 1 diabetes. The statistical significance observed after exclusion of the Sardinian data suggests that other environmental factors may operate over populations with different genetic susceptibility Diabet. Med. 29, 761766 (2012) Abstract Aims Several studies confirmed the growing rate of Type 1 diabetes mellitus in childhood coinciding with increasing diagnosis of viral infections. A study investigating the incidence of Type 1 diabetes during 19961997 showed a higher notification of viral infections in the Pavia District. The aim was to confirm these results. Methods This study evaluated the relationship between new cases of Type 1 diabetes and those of measles, mumps and rubella in 19962001, analysing data of newly-diagnosed Type 1 diabetes children, aged 014 years and enrolled into the RIDI (Italian Insulin-dependent Diabetes Registry) during the same years. Measles, rubella and mumps rates were calculated using as denominator the estimated population at risk, represented by the number of 0- to 14 year-old subjects who did not undergo the MMR (measles, mumps and rubella) vaccination. In order to investigate the association between Type 1 diabetes incidence and measles, rubella and mumps respectively, Spearmans rank correlation was used. Results The analysis of the whole Registries data did not at first show any statistical significance between age-standardized Type 1 diabetes incidence density and estimated rates of measles, mumps and rubella notifications. Excluding data from Sardinia Registry, a significant association was observed between Type 1 diabetes incidence and mumps (P = 0.034) and rubella (P = 0.014), respectively, while there was no statistical significance between the incidence of measles cases and diabetes rates (P = 0.269). Conclusions According to our findings, mumps and rubella viral infections are associated with the onset of Type 1 diabetes. The statistical significance observed after exclusion of the Sardinian data suggests that other environmental factors may operate over populations with different genetic susceptibility.

Published
2011

304. RIDI Study Group. Age-period-cohort analysis of 1990-2003 incidence time trends of childhood diabetes in Italy: the RIDI study

Author

BRUNO G, MAULE M, MERLETTI F, NOVELLI G, FALORNI A, IANNILLI A, IUGHETTI L, ALTOBELLI E, D'ANNUNZIO G, PIFFER S, POZZILLI P, IAFUSCO, Dario, SONGINI M, RONCAROLO, F, TONI S, CARLE F, CHERUBINI V., Bruno, G, Maule, M, Merletti, F, Novelli, G, Falorni, A, Iannilli, A, Iughetti, L, Altobelli, E, D'Annunzio, G, Piffer, S, Pozzilli, P, Iafusco, Dario, Songini, M, Roncarolo, F, Toni, S, Carle, F, and Cherubini, V.

Subjects
Male, Adolescent, Geography, Incidence, Infant, Likelihood Function, Diabetes Mellitus, Type 1, Italy, Child, Preschool, Female, Poisson Distribution, Registries, Cohort Studie, Child, Human
Abstract

OBJECTIVE - To investigate age-period-cohort effects on the temporal trend of type 1 diabetes in children age 0-14 years in Italian registries. RESEARCH DESIGN AND METHODS - This report is based on 5,180 incident cases in the period 1990-2003 from the Registry for Type 1 Diabetes Mellitus in Italy (RIDI). Multilevel (random intercept) Poisson regression models were used to model the effects of sex, age, calendar time, and birth cohorts on temporal trends, taking into account the registry-level variance component. RESULTS - The incidence rate was 12.26 per 100,000 personyears and significantly higher in boys (13.13 [95% CI 12.66-13.62]) than in girls (11.35 [10.90-11.82]). Large geographical variations in incidence within Italy were evident; incidence was highest in Sardinia, intermediate in Central-Southern Italy, and high in Northern Italy, particularly in the Trento Province, where the incidence rate was 18.67 per 100,000 person-years. An increasing temporal trend was evident (2.94% per year [95% CI 2.22-3.67]). With respect to the calendar period 1990-1992, the incidence rates increased linearly by 15, 27, 35, and 40% in the following time periods (P for trend < 0.001). With respect to the 1987-1993 birth cohort, the incidence rate ratio increased approximately linearly from 0.63 (95% CI 0.54-0.73) in the 1975-1981 cohort to 1.38 (1.06-1.80) in the 1999-2003 cohort. The best model, however, included sex, age, and a linear time trend (drift). CONCLUSIONS - Large geographical variations and an increasing temporal trend in diabetes incidence are evident among type 1 diabetic children in Italy. Age-period-cohort analysis shows that the variation over time has a linear component that cannot be ascribed to either the calendar period or the birth cohort. © 2010 by the American Diabetes Association.

Published
2010

305. Spatio-temporal correlates of taste processing in the human primary gustatory cortex

Author

N. Noennig, Thomas Hummel, A.M. Schoenfeld, and Emilia Iannilli

Subjects
Adult, Male, Electroencephalography, Stimulus (physiology), behavioral disciplines and activities, Brain mapping, Time, Physical Stimulation, medicine, Psychophysics, Humans, Evoked Potentials, Cerebral Cortex, Brain Mapping, medicine.diagnostic_test, General Neuroscience, Magnetoencephalography, Taste Perception, Signal Processing, Computer-Assisted, Magnetic Fields, Female, Psychology, Functional magnetic resonance imaging, Gustatory cortex, Neuroscience, Insula, psychological phenomena and processes
Abstract

In humans the identification of the primary gustatory cortex (PGC) is still under debate. Neuroimaging studies indicate insula and overlying opercula as the best candidates but the exact position of the PGC within this region is not entirely clear. Moreover, inconsistencies appear when comparing results from studies using functional magnetic resonance imaging (fMRI), and gustatory event-related potentials (gERP), or gustatory event-related magnetic fields (gERMF). fMRI indicates activations in the anterior part of the insula and frontal operculum, while gERP and/or gERMF indicate activations at the transition between the parietal operculum and insula in its posterior part. Here it is important to note that for gERP and gERMF temporal and spatial characteristics of the stimulus must be well controlled to evoke a useful brain response. In the present study gERMF and gERP were recorded simultaneously using a whole-head system with 249 magnetometers and 32 electrodes, respectively; taste stimuli were applied using a stimulator providing excellent temporal and spatial control of the stimulus. Separate ERP and ERMF averaged waveforms were derived time-locked to the onset of the taste stimuli. The source analysis for the early time range revealed activity in the left and right anterior and mid part of the insula, where in the later time range the sources were located more in the posterior part of the insula.

Published
2014

309. Severe hypoglycemia and ketoacidosis over one year in Italian pediatric population with type 1 diabetes mellitus: a multicenter retrospective observational study

Author

Cherubini, V, Pintaudi, B, Rossi, Mc, Lucisano, G, Pellegrini, F, Chiumello, G, Frongia, Ap, Monciotti, C, Patera, Ip, Toni, S, Zucchini, S, Nicolucci, A, Lera, R, Iannilli, A, Giorgetti, C, Cesaretti, A, Paparusso, Am, Alessandrelli, Mc, Scipione, M, Balsamo, C, Gallo, F, Lo Presti, D, Passanisi, S, Tumini, S, Cipriano, P, Lazzaro, N, Vergerio, A, Banin, P, Lenzi, L, Coccioli, Ms, D'Annunzio, G, Bruzzese, M, Lombardo, F, Salzano, G, Bonfanti, R, Frontino, G, Battaglino, R, Iughetti, Lorenzo, Predieri, Barbara, Cadario, F, Savastio, S, Zabadneh, N, Zanella, C, Mozzo, E, Tiozzo, S, Benevento, D, Calcaterra, V, Larizza, D, Delvecchio, M, Trada, M, Rabbone, I, Sicignano, S, Cauvin, V, Franceschi, R, Gargantini, L, Pennati, C, Bianchi, G, Salvatoni, A, Maffeis, C, Marigliano, M, Sabbion, A, Arnaldi, C, Tosini, D, Tossi, Mc, Valentini, M, D'Alonzo, D, Pirozzoli, C, Di Nardo, B, Memmo, R, and Cianci, A.

Subjects
Male, medicine.medical_specialty, Children and adolescents, endocrine system diseases, Adolescent, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulin, Isophane, Medicine (miscellaneous), NPH insulin, TYPE I (INSULIN-DEPENDENT) DIABETES MELLITUS, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Child, Retrospective Studies, Glycated Hemoglobin, Type 1 diabetes, Severe hypoglycemia, Nutrition and Dietetics, business.industry, Incidence (epidemiology), Incidence, Infant, Retrospective cohort study, Diabetes ketoacidosis, Ketosis, medicine.disease, Hypoglycemia, Ketoacidosis, Surgery, Diabetes Mellitus, Type 1, Italy, Child, Preschool, Regular insulin, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Background and aims: Evaluation of incidence and correlates of severe hypoglycemia (SH) and diabetes ketoacidosis (DKA) in children and adolescents with T1DM. Methods and results: Retrospective study conducted in 29 diabetes centers from November 2011 to April 2012. The incidence of SH and DKA episodes and their correlates were assessed through a questionnaire administered to parents of patients aged 0e18 years. Incidence rates and incident rate ratios (IRRs) were estimated through multivariate Poisson regression analysis and multilevel analysis. Overall, 2025 patients were included (age 12.4 � 3.8 years; 53% males; diabetes dura- tion 5.6 � 3.5 years; HbA1c 7.9 � 1.1%). The incidence of SH and DKA were of 7.7 and 2.4 events/ 100 py, respectively. The risk of SH was higher in females (IRR Z 1.44; 95%CI 1.04e1.99), in pa- tients using rapid acting analogues as compared to regular insulin (IRR Z 1.48; 95%CI 0.97e2.26) and lower for patients using long acting analogues as compared to NPH insulin (IRR Z 0.40; 95% CI 0.19e0.85). No correlations were found between SH and HbA1c levels. The risk of DKA was higher in patients using rapid acting analogues (IRR Z 4.25; 95%CI 1.01e17.86) and increased with insulin units needed (IRR Z 7.66; 95%CI 2.83e20.74) and HbA1c levels (IRR Z 1.63; 95% CI 1.36e1.95). Mother' sa ge was inversely associated with the risk of both SH (IRRZ 0.95; 95%CI 0.92e0.98) and DKA (IRR Z 0.94; 95%CI 0.88e0.99). When accounting for center effect, the risk of SH associated with the use of rapid acting insulin analogues was attenuated (IRR Z 1.48; 95%CI 0.97e2.26); 33% and 16% of the residual variance in SH and DKA risk was ex- plained by center effect. Conclusion: The risk of SH and DKA is mainly associated with treatment modalities and strongly depends on the practice of specialist centers.

Published
2014

310. Epidemiology of diabetic ketoacidosis in Italy

Author

Cherubini, V, Gesuita, R, Sternardi, S, Ferrito, L, Lenzi, L, Iannilli, A, Piccini, B, Skrami, E, Nicolucci, A, Pintaudi, B, Toni, S, Lera, R, De Luna, L, Kienberger, B, Gualtieri, A, Zecchino, C, Piccino, E, Ortolani, F, Zucchini, S, Maltoni, G, Pasquino, B, Reinstadler, P, Prandi, E, Zattoni, V, Gallo, F, Morganti, G, Guerraggio, L, Ripoli, C, Frongia, M, Pusceddu, P, La Loggia, A, Scanu, P, Cardinale, G, Ponzi, G, Tomaselli, L, G, Rapisarda, V, Citriniti, F, Soprani, T, Tumini, S, Lazzaro, N, De Donno, V, Banin, P, Mainetti, B, Coccioli, Ms, D'Annunzio, G, Minuto, N, Montani, E, Maccioni, R, Marongiu, U, Beccaria, L, Bruzzese, M, Mammì, F, Pardi, D, Lombardo, F, Ventrici, C, Scaramazza, A, Ferrari, M, Bonfanti, R, Rigamonti, A, Iughetti, L, Predieri, B, Iafusco, D, Confetto, S, Zanfardino, A, Prisco, F, Franzese, A, De Nitto, E, Cadario, F, Milia, A, Piredda, G, Mereu, L, Soro, M, Correddu, A, Pipia, A, Monciotti, C, Cardella, F, De Berardinis, F, Santoro, G, Chiari, G, Berioli, M, Federico, G, Zanette, G, Marsciani, A, Pedini, A, Patera, I, P, Schiaffini, R, Bitti, M, Lidano, R, Pietrosanti, S, Delvecchio, M, Trada, M, Marinaro, A, Meloni, G, Galero, A, Fichera, G, Bulciolu, P, Rabbone, I, Ignaccolo, G, Cauvin, V, Franceschi, R, Faleschini, E, Tornese, G, Salvatoni, Alessandro, Cardani, R, Maffeis, C, Marigliano, M, Sabbion, A, and Arnaldi, C.

Published
2014

314. An Integrated Quasi-Elastic Light-Scattering, Pulse-Gradient-Spin−Echo Study on the Transport Properties of α,α-Trehalose, Sucrose, and Maltose Deuterium Oxide Solutions

Author

Luciano Galantini, E. Tettamanti, Emilia Iannilli and, and Salvatore Magazù

Subjects
DYNAMICS, TREHALOSE AQUEOUS-SOLUTIONS, Chromatography, PROTEINS, Chemistry, TREHALOSE AQUEOUS-SOLUTIONS, SELF-DIFFUSION, HYDRATION, WATER, SIMULATION, DYNAMICS, PROTEINS, HYDRATION, Dispersity, Analytical chemistry, Disaccharide, Hard spheres, Maltose, Trehalose, Surfaces, Coatings and Films, Dilution, chemistry.chemical_compound, Deuterium, SELF-DIFFUSION, SIMULATION, Materials Chemistry, Spin echo, WATER, Physical and Theoretical Chemistry
Abstract

A study on D2O solutions of trehalose, maltose, and sucrose have been performed by using quasi-elastic light-scattering (QELS) and 1H and 2H pulse-gradient-spin−echo NMR (PGSE-NMR). The self-diffusion coefficient of disaccharide (D) and the apparent diffusion coefficient Dapp have been obtained as a function of disaccharide weight fraction c and temperature (20−60 °C). Hydrodynamic radii at infinite dilution have been evaluated. In case of trehalose and sucrose a model of monodisperse hard spheres has been used to interpret the concentration dependence of D and Dapp in the dilute region (c ≤ 0.1), thus obtaining the values of the hydrodynamic radii together with the diffusing particles volume fractions as a function of c and T. The invariance of the hydrodynamic radii and the agreement with the model suggest that T and c neither induce self-aggregation of the sugars nor affect sensitively their structure and hydration. The self-diffusion coefficient of D2O (Ds) at 20 °C has also been measured for the D2O ...

Published
2001
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315. Quality of life and treatment satisfaction in adults with Type 1 diabetes: a comparison between continuous subcutaneous insulin infusion and multiple daily injections

Author

A. Nicolucci, A. Maione, M. Franciosi, R. Amoretti, E. Busetto, F. Capani, D. Bruttomesso, P. Di Bartolo, A. Girelli, F. Leonetti, L. Morviducci, P. Ponzi, E. Vitacolonna, L. V. Cassano, N. Tota, V. Cherubini, A. Iannilli A. Corsi, P. Ponzani, V. Montani, P. Di Berardino, M. Velussi, F. Giorgino, V. Gigantelli, G. Beltramello, A. Pianta, R. Trevisan, G. Lepore, G. Forlani, G. Marchesini, D. Crazzolara, M. Marchesi, E. Zarra, B. Agosti, G. Careddu, L. Tomaselli, R. Vigneri, M. Agrusta, V. Di Blasi, S. Tumini, M. T. Anzellotti, P. Ruggeri, P. Foglini, M. Rossana, A Murri, S. Toni, M. F. Reali, M. Nizzoli, S. Aquati, G. d’Annunzio, N. Minuto, L. Cataldi, C. Bordone, R. Iannarelli, F. Sciarretta, M. Tagliaferri, M. A. Lezzi, L. Sciangula, A. Ciucci, M. Bonomo, E. Meneghini, G. Mariani, P. Colapinto, G. Testori, P. Rampini, R. Bonfanti, F. Meschi, G. Galimberti, A. Laurenzi, A. Veronelli, C. Mauri, C. Tortul, A. M. Cernigoi, M. E. De Feo, M. Piscopo, G. Annuzzi, L. Bozzetto, A. Franzese, P. Buono, S. Turco, A. Turco, F. Prisco, D. Iafusco, M. Trovati, P. Massucco, S. Costa, M, V. Provenzano, L. Strazzera, G. Ridola, E. Torlone, M. Orsini Federici, A. Bertolotto, M. Aragona, F. Pellicano, V. Manicardi, M. Michelini, M. Parenti, A. C. Babini, P. Borboni, A. Di Flaviani, M. L. Manca Bitti, S. Piccinini, A. Clementi, C. Tubili, C. Suraci, S. Carletti, A. Moretti, M. Maiello, V. C. Iannucci, N. Sulli, B. Shashaj, D. Fava, F. Massimiani, P. Pozzilli, S. Manfrini, C. Landi, I. Tanganelli, G. Grassi, M. Tomelini, R. De Luca, L. Corgiat Mansin, R. Candido, E. Manca, L. Tonutti, C. Noacco, I. Franzetti, P. Marnini., Nicolucci, A., Maione, A., Franciosi, M., Amoretti, R., Busetto, E., Capani, F., Bruttomesso, D., Di Bartolo, P., Girelli, A., Leonetti, F., Morviducci, L., Ponzi, P., Vitacolonna, E., Cassano, L. V., Tota, N., Cherubini, V., Corsi, A. Iannilli A., Ponzani, P., Montani, V., Di Berardino, P., Velussi, M., Giorgino, F., Gigantelli, V., Beltramello, G., Pianta, A., Trevisan, R., Lepore, G., Forlani, G., Marchesini, G., Crazzolara, D., Marchesi, M., Zarra, E., Agosti, B., Careddu, G., Tomaselli, L., Vigneri, R., Agrusta, M., Di Blasi, V., Tumini, S., Anzellotti, M. T., Ruggeri, P., Foglini, P., Rossana, M., Murri, A, Toni, S., Reali, M. F., Nizzoli, M., Aquati, S., D’Annunzio, G., Minuto, N., Cataldi, L., Bordone, C., Iannarelli, R., Sciarretta, F., Tagliaferri, M., Lezzi, M. A., Sciangula, L., Ciucci, A., Bonomo, M., Meneghini, E., Mariani, G., Colapinto, P., Testori, G., Rampini, P., Bonfanti, R., Meschi, F., Galimberti, G., Laurenzi, A., Veronelli, A., Mauri, C., Tortul, C., Cernigoi, A. M., De Feo, M. E., Piscopo, M., Annuzzi, G., Bozzetto, L., Franzese, A., Buono, P., Turco, S., Turco, A., Prisco, F., Iafusco, D., Trovati, M., Massucco, P., Costa, S., M, Provenzano, V., Strazzera, L., Ridola, G., Torlone, E., Orsini Federici, M., Bertolotto, A., Aragona, M., Pellicano, F., Manicardi, V., Michelini, M., Parenti, M., Babini, A. C., Borboni, P., Di Flaviani, A., Manca Bitti, M. L., Piccinini, S., Clementi, A., Tubili, C., Suraci, C., Carletti, S., Moretti, A., Maiello, M., Iannucci, V. C., Sulli, N., Shashaj, B., Fava, D., Massimiani, F., Pozzilli, P., Manfrini, S., Landi, C., Tanganelli, I., Grassi, G., Tomelini, M., De Luca, R., Corgiat Mansin, L., Candido, R., Manca, E., Tonutti, L., Noacco, C., Franzetti, I., and Marnini., P.

Subjects
multiple daily injections, Insulin pump, Adult, Male, medicine.medical_specialty, Continuous subcutaneous insulin infusion, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Injections, Subcutaneous, Insulin Glargine, Endocrinology, Patient satisfaction, Insulin Infusion Systems, Quality of life, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Insulin, Multiple daily injection, continuous subcutaneous insulin infusion, quality of life, questionnaires, type 1 diabetes, Type 1 diabetes, Questionnaire, Insulin glargine, business.industry, Middle Aged, medicine.disease, Obesity, Surgery, Insulin, Long-Acting, Diabetes Mellitus, Type 1, Patient Satisfaction, Quality of Life, Female, business, Epidemiologic Methods, medicine.drug
Abstract

Aims The aim of this case–control study was to compare quality of life (QoL) and treatment satisfaction in adults with Type 1 diabetes (T1DM) treated with either continuous subcutaneous insulin infusion (CSII) or multiple daily injections (MDI). Methods Consecutive patients aged between 18 and 55 years, and attending diabetes clinics for a routine visit, completed the Diabetes-Specific Quality-of-Life Scale (DSQOLS), the Diabetes Treatment Satisfaction Questionnaire (DTSQ) and the SF-36 Health Survey (SF-36). Case (CSII) and control subjects (MDI) were recruited in a 1 : 2 ratio. Results Overall, 1341 individuals were enrolled by 62 diabetes clinics; 481 were cases and 860 control subjects. Cases had a longer diabetes duration and were more likely to have eye and renal complications. Age, school education, occupation and HbA 1c were similar. Of control subjects, 90% followed glargine-based MDI regimens and 10% used NPH-based MDI regimens. On multivariate analysis, after adjusting for socioeconomic and clinical characteristics, scores in the following areas of the DSQOLS were higher in cases than control subjects: diet restrictions ( β = 5.96; P < 0.0001), daily hassles ( β = 3.57; P = 0.01) and fears about hypoglycaemia ( β = 3.88; P = 0.006). Treatment with CSII was also associated with a markedly higher DTSQ score ( β = 4.13; P < 0.0001) compared with MDI. Results were similar when CSII was compared separately with glargine- or NPH-based MDI regimens. Conclusions This large, non-randomized, case–control study suggests quality of life gains deriving from greater lifestyle flexibility, less fear of hypoglycaemia, and higher treatment satisfaction, when CSII is compared with either glargine-based or NPH-based MDI regimens. Diabet. Med. 25, 213–220 (2008)

Published
2008

316. The LHCb Detector at the LHC

Author

Alves, A, Andrade, L, Barbosa, A, Bediaga, I, Cernicchiaro, G, Guerrer, G, Lima, H, Machado, A, Magnin, J, Marujo, F, De Miranda, J, Reis, A, Santos, A, Toledo, A, Akiba, K, Amato, S, De Paula, B, De Paula, L, Da Silva, T, Gandelman, M, Lopes, J, Marechal, B, Moraes, D, Polycarpo, E, Rodrigues, F, Ballansat, J, Bastian, Y, Boget, D, De Bonis, I, Coco, V, David, P, Decamp, D, Delebecque, P, Drancourt, C, Dumont Dayot, N, Girard, C, Lieunard, B, Minard, M, Pietrzyk, B, Rambure, T, Rospabe, G, T'jampens, S, Ajaltouni, Z, Bohner, G, Bonnefoy, R, Borras, D, Carloganu, C, Chanal, H, Conte, E, Cornat, R, Crouau, M, Delage, E, Deschamps, O, Henrard, P, Jacquet, P, Lacan, C, Laubser, J, Lecoq, J, Lefvre, R, Magne, M, Martemiyanov, M, Mercier, M, Monteil, S, Niess, V, Perret, P, Reinmuth, G, Robert, A, Suchorski, S, Arnaud, K, Aslanides, E, Babel, J, Benchouk, C, Cachemiche, J, Cogan, J, Derue, F, Dinkespiler, B, Duval, P, Garonne, V, Favard, S, Le Gac, R, Leon, F, Leroy, O, Liotard, P, Marin, F, Menouni, M, Ollive, P, Poss, S, Roche, A, Sapunov, M, Tocco, L, Viaud, B, Tsaregorodtsev, A, Amhis, Y, Barrand, G, Barsuk, S, Beigbeder, C, Beneyton, R, Breton, D, Callot, O, Charlet, D, Ds'almagne, B, Duarte, O, Fulda Quenzer, F, Jacholkowska, A, Jean Marie, B, Lefrancois, J, Machefert, F, Robbe, P, Schune, M, Tocut, V, Videau, I, Benayoun, M, Del Buono, L, Gilles, G, Domke, M, Futterschneider, H, Ilgner, C, Kapusta, P, Kolander, M, Krause, R, Lieng, M, Nedos, M, Rudloff, K, Schleich, S, Schwierz, R, Spaan, B, Wacker, K, Warda, K, Agari, M, Bauer, C, Baumeister, D, Bulian, N, Fuchs, H, Fallot Burghardt, W, Glebe, T, Hofmann, W, Knopfle, K, Lochner, S, Ludwig, A, Maciuc, F, Nieto, F, Schmelling, M, Schwingenheuer, B, Sexauer, E, Smale, N, Trunk, U, Voss, H, Albrecht, J, Bachmann, S, Blouw, J, Deissenroth, M, Deppe, H, Dreis, H, Eisele, F, Haas, T, Hansmann Menzemer, S, Hennenberger, S, Knopf, J, Moch, M, Perieanu, A, Rabenecker, S, Rausch, A, Rummel, C, Rusnyak, R, Schiller, M, Stange, U, Uwer, U, Walter, M, Ziegler, R, Avoni, G, Balbi, G, Bonifazi, F, Bortolotti, D, Carbone, A, D'antone, I, Galli, D, Gregori, D, Lax, I, Marconi, U, Peco, G, Vagnoni, V, Valenti, G, Vecchi, S, Bonivento, W, Cardini, A, Cadeddu, S, Deleo, V, Deplano, C, Furcas, S, Lai, A, Oldeman, R, Raspino, D, Saitta, B, Serra, N, Baldini, W, Brusa, S, Chiozzi, S, Ramusino, A, Evangelisti, F, Franconieri, A, Germani, S, Gianoli, A, Guoming, L, Landi, L, Malaguti, R, Padoan, C, Pennini, C, Savrie, M, Squerzanti, S, Zhao, T, Zhu, M, Bizzeti, A, Graziani, G, Lenti, M, Lenzi, M, Maletta, F, Pennazzi, S, Passaleva, G, Veltri, M, Alfonsi, M, Anelli, M, Balla, A, Battisti, A, Bencivenni, G, Campana, P, Carletti, M, Ciambrone, P, Corradi, G, Dane, E, Divirgilio, A, Desimone, P, Felici, G, Forti, C, Gatta, M, Lanfranchi, G, Murtas, F, Pistilli, M, Lener, M, Rosellini, R, Santoni, M, Saputi, A, Sarti, A, Sciubba, A, Zossi, A, Ameri, M, Cuneo, S, Fontanelli, F, Gracco, V, Mini, G, Parodi, M, Petrolini, A, Sannino, M, Vinci, A, Alemi, M, Arnaboldi, C, Bellunato, T, Chignoli, F, De Lucia, A, Galotta, G, Mazza, R, Matteuzzi, C, Musy, M, Negri, P, Perego, D, Pessina, G, Auriemma, G, Bocci, V, Buccheri, A, Chiodi, G, Di Marco, S, Iacoangeli, F, Martellotti, G, Nobrega, R, Pelosi, A, Penso, G, Pinci, D, Rinaldi, W, Rossi, A, Santacesaria, R, Satriano, C, Carboni, G, Iannilli, M, Rodrigues, A, Messi, R, Paoluzzi, G, Sabatino, G, Santovetti, E, Satta, A, Amoraal, J, Van Apeldoorn, G, Arink, R, Van Bakel, N, Band, H, Bauer, T, Berkien, A, Van Beuzekom, M, Bos, E, Bron, C, Ceelie, L, Doets, M, Van Der Eijk, R, Fransen, J, De Groen, P, Gromov, V, Hierck, R, Homma, J, Hommels, B, Hoogland, W, Jans, E, Jansen, F, Jansen, L, Jaspers, M, Kaan, B, Koene, B, Koopstra, J, Kroes, F, Kraan, M, Langedijk, J, Merk, M, Mos, S, Munneke, B, Palacios, J, Papadclis, A, Pellegrino, A, Van Petten, O, Du Pree, T, Roeland, E, Ruckstuhl, W, Schimmel, A, Schuijlenburg, H, Sluijk, T, Spelt, J, Stolte, J, Terrier, H, Tuning, N, Van Lysebetten, A, Vankov, P, Verkooijen, J, Verlaat, B, Vink, W, De Vries, H, Wiggers, L, Smit, G, Zaitsev, N, Zupan, M, Zwart, A, Van Den Brand, J, Bulten, H, De Jong, M, Ketel, T, Klous, S, Kos, J, M'charek, B, Mul, F, Raven, G, Simioni, E, Cheng, J, Dai, G, Deng, Z, Gao, Y, Gong, G, Gong, H, He, J, Hou, L, Li, J, Qian, W, Shao, B, Xue, T, Yang, Z, Zeng, M, Muryn, B, Ciba, K, Oblakowska Mucha, A, Blocki, J, Galuszka, K, Hajduk, L, Michalowski, J, Natkaniec, Z, Polok, G, Stodulski, M, Witek, M, Brzozowski, K, Chlopik, A, Gawor, P, Guzik, Z, Nawrot, A, Srednicki, A, Syryczynski, K, Szczekowski, M, Anghel, D, Cimpean, A, Coca, C, Constantin, F, Cristian, P, Dumitru, D, Giolu, G, Kusko, C, Magureanu, C, Mihon, G, Orlandea, M, Pavel, C, Petrescu, R, Popescu, S, Preda, T, Rosca, A, Rusu, V, Stoica, R, Stoica, S, Tarta, P, Filippov, S, Gavrilov, Y, Golyshkin, L, Gushchin, E, Karavichev, O, Klubakov, V, Kravchuk, L, Kutuzov, V, Laptev, S, Popov, S, Aref'ev, A, Bobchenko, B, Dolgoshein, V, Egorychev, V, Golutvin, A, Gushchin, O, Konoplyannikov, A, Korolko, I, Kvaratskheliya, T, Machikhiliyan, I, Malyshev, S, Mayatskaya, E, Prokudin, M, Rusinov, D, Rusinov, V, Shatalov, P, Shchutska, L, Tarkovskiy, E, Tayduganov, A, Voronchev, K, Zhiryakova, O, Bobrov, A, Bondar, A, Eidelman, S, Kozlinsky, A, Shekhtman, L, Beloous, K, Dzhelyadin, R, Gelitsky, Y, Gouz, Y, Kachnov, K, Kobelev, A, Matveev, V, Novikov, V, Obraztsov, V, Ostankov, A, Romanovsky, V, Rykalin, V, Soldatov, A, Soldatov, M, Tchernov, E, Yushchenko, O, Bochin, B, Bondar, N, Fedorov, O, Golovtsov, V, Guets, S, Kashchuk, A, Lazarev, V, Maev, O, Neustroev, P, Sagidova, N, Spiridenkov, E, Volkov, S, Vorobyev, A, Vorobyov, A, Aguilo, E, Bota, S, Calvo, M, Comerma, A, Cano, X, Dieguez, A, Herms, A, Lopez, E, Luengo, S, Garra, J, Garrido, L, Gascon, D, De Valenzuela, A, Gonzalez, C, Graciani, R, Grauges, E, Calero, A, Picatoste, E, Riera, J, Rosello, M, Ruiz, H, Vilasis, X, Xirgu, X, Adeva, B, Vidal, X, Santos, D, Pereira, D, Pazos, J, Torreira, A, Gomez, C, Alvarez, A, Trigo, E, Casasus, M, Cobo, C, Perez, P, Saborido, J, Seco, M, Regueiro, P, Bartalini, P, Bay, A, Bettler, M, Blanc, F, Borel, J, Carron, B, Currat, C, Conti, G, Dormond, O, Ermoline, Y, Fauland, P, Fernandez, L, Frei, R, Gagliardi, G, Gueissaz, N, Haefeli, G, Hicheur, A, Jacoby, C, Jalocha, P, Jimenez Otcro, S, Hertig, J, Knecht, M, Legger, F, Locatelli, L, Moser, J, Needham, M, Nicolas, L, Perrin Giacomin, A, Perroud, J, Potterat, C, Ronga, F, Schneider, O, Schietinger, T, Steele, D, Studer, L, Tareb, M, Tran, M, Van Hunen, J, Vervink, K, Villa, S, Zwahlen, N, Bernet, R, Buchler, A, Gassner, J, Lehner, F, Sakhelashvili, T, Salzmann, C, Sievers, P, Steiner, S, Steinkamp, O, Straumann, U, Van Tilburg, J, Vollhardt, A, Volyanskyy, D, Ziegler, M, Dovbnya, A, Ranyuk, Y, Shapoval, I, Borisova, M, Lakovenko, V, Kyva, V, Kovalchuk, O, Okhrimenko, O, Pugatch, V, Pylypchenko, Y, Adinolfi, M, Brook, N, Head, R, Imong, J, Lessnoff, K, Metlica, F, Muir, A, Rademacker, J, Solomin, A, Szczypka, P, Barham, C, Buszello, C, Dickens, J, Gibson, V, Haines, S, Harrison, K, Jones, C, Katvars, S, Kerzel, U, Lazzeroni, C, Li, Y, Rogers, G, Storey, J, Skottowe, H, Wotton, S, Adye, T, Densham, C, Easo, S, Franek, B, Loveridge, P, Morrow, D, Morris, J, Nandakumar, R, Nardulli, J, Papanestis, A, Patrick, G, Ricciardi, S, Woodward, M, Zhang, Z, Chamonal, R, Clark, P, Clarke, P, Eisenhardt, S, Gilardi, N, Khan, A, Kim, Y, Lambert, R, Lawrence, J, Main, A, Mccarron, J, Mclean, C, Muheim, F, Osorio Oliveros, A, Playfer, S, Styles, N, Xie, Y, Bates, A, Carson, L, Marinho, F, Doherty, F, Eklund, L, Gersabeck, M, Haddad, L, Macgregor, A, Melone, J, Mcewan, F, Petrie, D, Paterson, S, Parkes, C, Pickford, A, Rakotomiaramanana, B, Rodrigues, E, Saavedra, A, Soler, F, Szumlak, T, Viret, S, Allebone, L, Awunor, O, Back, J, Barber, G, Barnes, C, Cameron, B, Clark, D, Clark, I, Dornan, P, Duane, A, Eames, C, Egede, U, Girone, M, Greenwood, S, Hallam, R, Hare, R, Howard, A, Jolly, S, Kasey, V, Khaleeq, M, Koppenburg, P, Miller, D, Plackett, R, Price, D, Reece, W, Savage, P, Savidge, T, Simmons, B, Vidal Sitjes, G, Websdale, D, Affolder, A, Anderson, J, Biagi, S, Bowcock, T, Carroll, J, Casse, G, Cooke, P, Donleavy, S, Dwyer, L, Hennessy, K, Huse, T, Hutchcroft, D, Jones, D, Lockwood, M, Mccubbin, M, Mcnulty, R, Muskett, D, Noor, A, Patel, G, Rinnert, K, Shears, T, Smith, N, Southern, G, Stavitski, I, Sutcliffe, P, Tobin, M, Traynor, S, Turner, P, Whitley, M, Wormald, M, Wright, V, Bibby, J, Brisbane, S, Brock, M, Charles, M, Ciolfi, C, Gligorov, V, Handford, T, Harnew, N, Harris, F, John, M, Jones, M, Libby, J, Martin, L, Mcarthur, I, Muresan, R, Newby, C, Ottewell, B, Powell, A, Rotolo, N, Senanayake, R, Somerville, L, Soroko, A, Spradlin, P, Sullivan, P, Stokes Rees, I, Topp Jorgensen, S, Xing, F, Wilkinson, G, Artuso, M, Belyaev, I, Blusk, S, Lefeuvre, G, Menaa, N, Menaa Sia, R, Mountain, R, Skwarnicki, T, Stone, S, Wang, J, Abadie, L, Aglieri Rinella, G, Albrecht, E, Andre, J, Anelli, G, Arnaud, N, Augustinus, A, Bal, F, Pazos, M, Barczyk, A, Bargiotti, M, Behrendt, O, Berni, S, Binko, P, Bobillier, V, Braem, A, Brarda, L, Buytaert, J, Camilleri, L, Cambpell, M, Castellani, G, Cataneo, F, Cattaneo, M, Chadaj, B, Charpentier, P, Cherukuwadal, S, Chesi, E, Christiansen, J, Chytracek, R, Clemencic, M, Closier, J, Collins, P, Colrain, P, Cooke, O, Corajod, B, Corti, G, D'ambrosio, C, Damodaranl, B, David, C, De Capua, S, Decreuse, G, Degaudenzi, H, Dijkstra, H, Droulez, J, Ramos, D, Dufey, J, Dumps, R, Eckstein, D, Ferro Luzzi, M, Fiedler, F, Filthaut, F, Flegel, W, Forty, R, Fournier, C, Frank, M, Frei, C, Gaidioz, B, Gaspar, C, Gayde, J, Gavillet, P, Go, A, Abril, G, Graulich, J, Giudici, P, Elias, A, Guglielmini, P, Gys, T, Hahn, F, Haider, S, Harvey, J, Hay, B, Morata, J, Alvarez, J, Van Herwijnen, E, Hilke, H, Von Holtey, G, Hulsbergen, W, Jacobsson, R, Jamet, O, Joram, C, Jost, B, Kanaya, N, Refolio, J, Koestner, S, Koratzinos, M, Kristic, R, Lacarrere, D, Lasseur, C, Lastovicka, T, Laub, M, Liko, D, Lippmann, C, Lindner, R, Losasso, M, Maier, A, Mair, K, Maley, P, Vila, P, Moine, G, Morant, J, Moritz, M, Moscicki, J, Muecke, M, Mueller, H, Nakada, T, Neufeld, N, Ocariz, J, Aranda, C, Parzefall, U, Patel, M, Pepe Altarelli, M, Piedigrossi, D, Pivk, M, Pokorski, W, Ponce, S, Ranjard, F, Riegler, W, Renaud, J, Roiser, S, Roy, L, Ruf, T, Ruffinoni, D, Saladino, S, Varela, A, Santinelli, R, Schmelling, S, Schmidt, B, Schneider, T, Schoning, A, Schopper, A, Seguinot, J, Snoeys, W, Smith, A, Somogyi, P, Stoical, R, Tejessy, W, Teubert, F, Thomas, E, Alarcon, J, Ullaland, O, Valassi, A, Vannerem, P, Veness, R, Wicht, P, Wiedner, D, Witzeling, W, Wright, A, Wyllie, K, Ypsilantis, T., CALVI, MARTA, Alves, A, Andrade, L, Barbosa, A, Bediaga, I, Cernicchiaro, G, Guerrer, G, Lima, H, Machado, A, Magnin, J, Marujo, F, De Miranda, J, Reis, A, Santos, A, Toledo, A, Akiba, K, Amato, S, De Paula, B, De Paula, L, Da Silva, T, Gandelman, M, Lopes, J, Marechal, B, Moraes, D, Polycarpo, E, Rodrigues, F, Ballansat, J, Bastian, Y, Boget, D, De Bonis, I, Coco, V, David, P, Decamp, D, Delebecque, P, Drancourt, C, Dumont Dayot, N, Girard, C, Lieunard, B, Minard, M, Pietrzyk, B, Rambure, T, Rospabe, G, T'Jampens, S, Ajaltouni, Z, Bohner, G, Bonnefoy, R, Borras, D, Carloganu, C, Chanal, H, Conte, E, Cornat, R, Crouau, M, Delage, E, Deschamps, O, Henrard, P, Jacquet, P, Lacan, C, Laubser, J, Lecoq, J, Lefvre, R, Magne, M, Martemiyanov, M, Mercier, M, Monteil, S, Niess, V, Perret, P, Reinmuth, G, Robert, A, Suchorski, S, Arnaud, K, Aslanides, E, Babel, J, Benchouk, C, Cachemiche, J, Cogan, J, Derue, F, Dinkespiler, B, Duval, P, Garonne, V, Favard, S, Le Gac, R, Leon, F, Leroy, O, Liotard, P, Marin, F, Menouni, M, Ollive, P, Poss, S, Roche, A, Sapunov, M, Tocco, L, Viaud, B, Tsaregorodtsev, A, Amhis, Y, Barrand, G, Barsuk, S, Beigbeder, C, Beneyton, R, Breton, D, Callot, O, Charlet, D, Ds'Almagne, B, Duarte, O, Fulda Quenzer, F, Jacholkowska, A, Jean Marie, B, Lefrancois, J, Machefert, F, Robbe, P, Schune, M, Tocut, V, Videau, I, Benayoun, M, Del Buono, L, Gilles, G, Domke, M, Futterschneider, H, Ilgner, C, Kapusta, P, Kolander, M, Krause, R, Lieng, M, Nedos, M, Rudloff, K, Schleich, S, Schwierz, R, Spaan, B, Wacker, K, Warda, K, Agari, M, Bauer, C, Baumeister, D, Bulian, N, Fuchs, H, Fallot Burghardt, W, Glebe, T, Hofmann, W, Knopfle, K, Lochner, S, Ludwig, A, Maciuc, F, Nieto, F, Schmelling, M, Schwingenheuer, B, Sexauer, E, Smale, N, Trunk, U, Voss, H, Albrecht, J, Bachmann, S, Blouw, J, Deissenroth, M, Deppe, H, Dreis, H, Eisele, F, Haas, T, Hansmann Menzemer, S, Hennenberger, S, Knopf, J, Moch, M, Perieanu, A, Rabenecker, S, Rausch, A, Rummel, C, Rusnyak, R, Schiller, M, Stange, U, Uwer, U, Walter, M, Ziegler, R, Avoni, G, Balbi, G, Bonifazi, F, Bortolotti, D, Carbone, A, D'Antone, I, Galli, D, Gregori, D, Lax, I, Marconi, U, Peco, G, Vagnoni, V, Valenti, G, Vecchi, S, Bonivento, W, Cardini, A, Cadeddu, S, Deleo, V, Deplano, C, Furcas, S, Lai, A, Oldeman, R, Raspino, D, Saitta, B, Serra, N, Baldini, W, Brusa, S, Chiozzi, S, Ramusino, A, Evangelisti, F, Franconieri, A, Germani, S, Gianoli, A, Guoming, L, Landi, L, Malaguti, R, Padoan, C, Pennini, C, Savrie, M, Squerzanti, S, Zhao, T, Zhu, M, Bizzeti, A, Graziani, G, Lenti, M, Lenzi, M, Maletta, F, Pennazzi, S, Passaleva, G, Veltri, M, Alfonsi, M, Anelli, M, Balla, A, Battisti, A, Bencivenni, G, Campana, P, Carletti, M, Ciambrone, P, Corradi, G, Dane, E, Divirgilio, A, Desimone, P, Felici, G, Forti, C, Gatta, M, Lanfranchi, G, Murtas, F, Pistilli, M, Lener, M, Rosellini, R, Santoni, M, Saputi, A, Sarti, A, Sciubba, A, Zossi, A, Ameri, M, Cuneo, S, Fontanelli, F, Gracco, V, Mini, G, Parodi, M, Petrolini, A, Sannino, M, Vinci, A, Alemi, M, Arnaboldi, C, Bellunato, T, Calvi, M, Chignoli, F, De Lucia, A, Galotta, G, Mazza, R, Matteuzzi, C, Musy, M, Negri, P, Perego, D, Pessina, G, Auriemma, G, Bocci, V, Buccheri, A, Chiodi, G, Di Marco, S, Iacoangeli, F, Martellotti, G, Nobrega, R, Pelosi, A, Penso, G, Pinci, D, Rinaldi, W, Rossi, A, Santacesaria, R, Satriano, C, Carboni, G, Iannilli, M, Rodrigues, A, Messi, R, Paoluzzi, G, Sabatino, G, Santovetti, E, Satta, A, Amoraal, J, Van Apeldoorn, G, Arink, R, Van Bakel, N, Band, H, Bauer, T, Berkien, A, Van Beuzekom, M, Bos, E, Bron, C, Ceelie, L, Doets, M, Van Der Eijk, R, Fransen, J, De Groen, P, Gromov, V, Hierck, R, Homma, J, Hommels, B, Hoogland, W, Jans, E, Jansen, F, Jansen, L, Jaspers, M, Kaan, B, Koene, B, Koopstra, J, Kroes, F, Kraan, M, Langedijk, J, Merk, M, Mos, S, Munneke, B, Palacios, J, Papadclis, A, Pellegrino, A, Van Petten, O, Du Pree, T, Roeland, E, Ruckstuhl, W, Schimmel, A, Schuijlenburg, H, Sluijk, T, Spelt, J, Stolte, J, Terrier, H, Tuning, N, Van Lysebetten, A, Vankov, P, Verkooijen, J, Verlaat, B, Vink, W, De Vries, H, Wiggers, L, Smit, G, Zaitsev, N, Zupan, M, Zwart, A, Van Den Brand, J, Bulten, H, De Jong, M, Ketel, T, Klous, S, Kos, J, M'Charek, B, Mul, F, Raven, G, Simioni, E, Cheng, J, Dai, G, Deng, Z, Gao, Y, Gong, G, Gong, H, He, J, Hou, L, Li, J, Qian, W, Shao, B, Xue, T, Yang, Z, Zeng, M, Muryn, B, Ciba, K, Oblakowska Mucha, A, Blocki, J, Galuszka, K, Hajduk, L, Michalowski, J, Natkaniec, Z, Polok, G, Stodulski, M, Witek, M, Brzozowski, K, Chlopik, A, Gawor, P, Guzik, Z, Nawrot, A, Srednicki, A, Syryczynski, K, Szczekowski, M, Anghel, D, Cimpean, A, Coca, C, Constantin, F, Cristian, P, Dumitru, D, Giolu, G, Kusko, C, Magureanu, C, Mihon, G, Orlandea, M, Pavel, C, Petrescu, R, Popescu, S, Preda, T, Rosca, A, Rusu, V, Stoica, R, Stoica, S, Tarta, P, Filippov, S, Gavrilov, Y, Golyshkin, L, Gushchin, E, Karavichev, O, Klubakov, V, Kravchuk, L, Kutuzov, V, Laptev, S, Popov, S, Aref'Ev, A, Bobchenko, B, Dolgoshein, V, Egorychev, V, Golutvin, A, Gushchin, O, Konoplyannikov, A, Korolko, I, Kvaratskheliya, T, Machikhiliyan, I, Malyshev, S, Mayatskaya, E, Prokudin, M, Rusinov, D, Rusinov, V, Shatalov, P, Shchutska, L, Tarkovskiy, E, Tayduganov, A, Voronchev, K, Zhiryakova, O, Bobrov, A, Bondar, A, Eidelman, S, Kozlinsky, A, Shekhtman, L, Beloous, K, Dzhelyadin, R, Gelitsky, Y, Gouz, Y, Kachnov, K, Kobelev, A, Matveev, V, Novikov, V, Obraztsov, V, Ostankov, A, Romanovsky, V, Rykalin, V, Soldatov, A, Soldatov, M, Tchernov, E, Yushchenko, O, Bochin, B, Bondar, N, Fedorov, O, Golovtsov, V, Guets, S, Kashchuk, A, Lazarev, V, Maev, O, Neustroev, P, Sagidova, N, Spiridenkov, E, Volkov, S, Vorobyev, A, Vorobyov, A, Aguilo, E, Bota, S, Calvo, M, Comerma, A, Cano, X, Dieguez, A, Herms, A, Lopez, E, Luengo, S, Garra, J, Garrido, L, Gascon, D, De Valenzuela, A, Gonzalez, C, Graciani, R, Grauges, E, Calero, A, Picatoste, E, Riera, J, Rosello, M, Ruiz, H, Vilasis, X, Xirgu, X, Adeva, B, Vidal, X, Santos, D, Pereira, D, Pazos, J, Torreira, A, Gomez, C, Alvarez, A, Trigo, E, Casasus, M, Cobo, C, Perez, P, Saborido, J, Seco, M, Regueiro, P, Bartalini, P, Bay, A, Bettler, M, Blanc, F, Borel, J, Carron, B, Currat, C, Conti, G, Dormond, O, Ermoline, Y, Fauland, P, Fernandez, L, Frei, R, Gagliardi, G, Gueissaz, N, Haefeli, G, Hicheur, A, Jacoby, C, Jalocha, P, Jimenez Otcro, S, Hertig, J, Knecht, M, Legger, F, Locatelli, L, Moser, J, Needham, M, Nicolas, L, Perrin Giacomin, A, Perroud, J, Potterat, C, Ronga, F, Schneider, O, Schietinger, T, Steele, D, Studer, L, Tareb, M, Tran, M, Van Hunen, J, Vervink, K, Villa, S, Zwahlen, N, Bernet, R, Buchler, A, Gassner, J, Lehner, F, Sakhelashvili, T, Salzmann, C, Sievers, P, Steiner, S, Steinkamp, O, Straumann, U, Van Tilburg, J, Vollhardt, A, Volyanskyy, D, Ziegler, M, Dovbnya, A, Ranyuk, Y, Shapoval, I, Borisova, M, Lakovenko, V, Kyva, V, Kovalchuk, O, Okhrimenko, O, Pugatch, V, Pylypchenko, Y, Adinolfi, M, Brook, N, Head, R, Imong, J, Lessnoff, K, Metlica, F, Muir, A, Rademacker, J, Solomin, A, Szczypka, P, Barham, C, Buszello, C, Dickens, J, Gibson, V, Haines, S, Harrison, K, Jones, C, Katvars, S, Kerzel, U, Lazzeroni, C, Li, Y, Rogers, G, Storey, J, Skottowe, H, Wotton, S, Adye, T, Densham, C, Easo, S, Franek, B, Loveridge, P, Morrow, D, Morris, J, Nandakumar, R, Nardulli, J, Papanestis, A, Patrick, G, Ricciardi, S, Woodward, M, Zhang, Z, Chamonal, R, Clark, P, Clarke, P, Eisenhardt, S, Gilardi, N, Khan, A, Kim, Y, Lambert, R, Lawrence, J, Main, A, Mccarron, J, Mclean, C, Muheim, F, Osorio Oliveros, A, Playfer, S, Styles, N, Xie, Y, Bates, A, Carson, L, Marinho, F, Doherty, F, Eklund, L, Gersabeck, M, Haddad, L, Macgregor, A, Melone, J, Mcewan, F, Petrie, D, Paterson, S, Parkes, C, Pickford, A, Rakotomiaramanana, B, Rodrigues, E, Saavedra, A, Soler, F, Szumlak, T, Viret, S, Allebone, L, Awunor, O, Back, J, Barber, G, Barnes, C, Cameron, B, Clark, D, Clark, I, Dornan, P, Duane, A, Eames, C, Egede, U, Girone, M, Greenwood, S, Hallam, R, Hare, R, Howard, A, Jolly, S, Kasey, V, Khaleeq, M, Koppenburg, P, Miller, D, Plackett, R, Price, D, Reece, W, Savage, P, Savidge, T, Simmons, B, Vidal Sitjes, G, Websdale, D, Affolder, A, Anderson, J, Biagi, S, Bowcock, T, Carroll, J, Casse, G, Cooke, P, Donleavy, S, Dwyer, L, Hennessy, K, Huse, T, Hutchcroft, D, Jones, D, Lockwood, M, Mccubbin, M, Mcnulty, R, Muskett, D, Noor, A, Patel, G, Rinnert, K, Shears, T, Smith, N, Southern, G, Stavitski, I, Sutcliffe, P, Tobin, M, Traynor, S, Turner, P, Whitley, M, Wormald, M, Wright, V, Bibby, J, Brisbane, S, Brock, M, Charles, M, Ciolfi, C, Gligorov, V, Handford, T, Harnew, N, Harris, F, John, M, Jones, M, Libby, J, Martin, L, Mcarthur, I, Muresan, R, Newby, C, Ottewell, B, Powell, A, Rotolo, N, Senanayake, R, Somerville, L, Soroko, A, Spradlin, P, Sullivan, P, Stokes Rees, I, Topp Jorgensen, S, Xing, F, Wilkinson, G, Artuso, M, Belyaev, I, Blusk, S, Lefeuvre, G, Menaa, N, Menaa Sia, R, Mountain, R, Skwarnicki, T, Stone, S, Wang, J, Abadie, L, Aglieri Rinella, G, Albrecht, E, Andre, J, Anelli, G, Arnaud, N, Augustinus, A, Bal, F, Pazos, M, Barczyk, A, Bargiotti, M, Behrendt, O, Berni, S, Binko, P, Bobillier, V, Braem, A, Brarda, L, Buytaert, J, Camilleri, L, Cambpell, M, Castellani, G, Cataneo, F, Cattaneo, M, Chadaj, B, Charpentier, P, Cherukuwadal, S, Chesi, E, Christiansen, J, Chytracek, R, Clemencic, M, Closier, J, Collins, P, Colrain, P, Cooke, O, Corajod, B, Corti, G, D'Ambrosio, C, Damodaranl, B, David, C, De Capua, S, Decreuse, G, Degaudenzi, H, Dijkstra, H, Droulez, J, Ramos, D, Dufey, J, Dumps, R, Eckstein, D, Ferro Luzzi, M, Fiedler, F, Filthaut, F, Flegel, W, Forty, R, Fournier, C, Frank, M, Frei, C, Gaidioz, B, Gaspar, C, Gayde, J, Gavillet, P, Go, A, Abril, G, Graulich, J, Giudici, P, Elias, A, Guglielmini, P, Gys, T, Hahn, F, Haider, S, Harvey, J, Hay, B, Morata, J, Alvarez, J, Van Herwijnen, E, Hilke, H, Von Holtey, G, Hulsbergen, W, Jacobsson, R, Jamet, O, Joram, C, Jost, B, Kanaya, N, Refolio, J, Koestner, S, Koratzinos, M, Kristic, R, Lacarrere, D, Lasseur, C, Lastovicka, T, Laub, M, Liko, D, Lippmann, C, Lindner, R, Losasso, M, Maier, A, Mair, K, Maley, P, Vila, P, Moine, G, Morant, J, Moritz, M, Moscicki, J, Muecke, M, Mueller, H, Nakada, T, Neufeld, N, Ocariz, J, Aranda, C, Parzefall, U, Patel, M, Pepe Altarelli, M, Piedigrossi, D, Pivk, M, Pokorski, W, Ponce, S, Ranjard, F, Riegler, W, Renaud, J, Roiser, S, Roy, L, Ruf, T, Ruffinoni, D, Saladino, S, Varela, A, Santinelli, R, Schmelling, S, Schmidt, B, Schneider, T, Schoning, A, Schopper, A, Seguinot, J, Snoeys, W, Smith, A, Somogyi, P, Stoical, R, Tejessy, W, Teubert, F, Thomas, E, Alarcon, J, Ullaland, O, Valassi, A, Vannerem, P, Veness, R, Wicht, P, Wiedner, D, Witzeling, W, Wright, A, Wyllie, K, Ypsilantis, T, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), LHCb, Theoretical Physics, Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Universitat Politècnica de València. Departamento de Ingeniería Electrónica - Departament d'Enginyeria Electrònica, and Universitat Politècnica de València. Instituto de Instrumentación para Imagen Molecular - Institut d'Instrumentació per a Imatge Molecular

Subjects
visible and IR photons, PROTOTYPE, Physics::Instrumentation and Detectors, Hadron, Large detector systems for particle and astroparticle physics, Particle tracking detectors, Gaseous detectors, Calorimeters, Cherenkov detectors, Particle identification methods, Photon detectors for UV, Detector alignment and calibration methods, Detector cooling and thermo-stabilization, Detector design and construction technologies and materials, 7. Clean energy, 01 natural sciences, Settore FIS/04 - Fisica Nucleare e Subnucleare, Detectors and Experimental Techniques, Nuclear Experiment, Instrumentation, Mathematical Physics, Physics, GEM, Large Hadron Collider, Detector, CP violation, MWPCS, Particle physics, calorimeters, cherenkov detectors, detector alignment and calibration methods, detector cooling and thermo-stabilization, detector design and construction technologies and materials, gaseous detectors, large detector systems for particle and astroparticle physics, particle identification methods, particle tracking detectors, photon detectors for uv, visible and ir photons, NO, Nuclear physics, TECNOLOGIA ELECTRONICA, Photon detectors for UV, visible and IR photons, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], SILICON, 010306 general physics, READ-OUT, 010308 nuclear & particles physics, Particle Physics Detector, High Energy Physics::Phenomenology, AEROGEL, PERFORMANCE, Large detector systems for particle and astroparticle physics, Particle tracking detectors, Gaseous detectors, Calorimeters, Cherenkov detectors, Particle identification methods, Photon detectors for UV, visible and IR photons, Detector alignment and calibration methods, Detector cooling and thermo-stabilization, Detector design and construction technologies and materials, Test beam, OPERATION, Physics::Accelerator Physics, High Energy Physics::Experiment, MUON CHAMBERS, SYSTEM
Abstract

Large detector systems for particle and astroparticle physics; Particle tracking detectors; Gaseous detectors; Calorimeters; Cherenkov detectors; Particle identification methods; Photon detectors for UV. visible and IR photons; Detector alignment and calibration methods; Detector cooling and thermo-stabilization; Detector design and construction technologies and materials. The LHCb experiment is dedicated to precision measurements of CP violation and rare decays of B hadrons at the Large Hadron Collider (LHC) at CERN (Geneva). The initial configuration and expected performance of the detector and associated systems. as established by test beam measurements and simulation studies. is described. © 2008 IOP Publishing Ltd and SISSA.

Published
2008
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317. Olfactory short-term memory encoding and maintenance - an event-related potential study

Author

Steffen Lenk, Thomas Hummel, Stephan Bender, Annet Bluschke, Emilia Iannilli, Christian Beste, and Veit Rößner

Subjects
Adult, Male, Cognitive Neuroscience, media_common.quotation_subject, Short-term memory, Lateralization of brain function, Young Adult, Stimulus modality, Discrimination, Psychological, Event-related potential, Encoding (memory), Perception, Humans, Olfactory memory, Evoked Potentials, media_common, Brain, Electroencephalography, Olfactory Perception, Memory, Short-Term, Neurology, Female, Baddeley's model of working memory, Psychology, Neuroscience, Cognitive psychology
Abstract

This study examined whether the memory encoding and short term maintenance of olfactory stimuli is associated with neurophysiological activation patterns which parallel those described for sensory modalities such as vision and auditory. We examined olfactory event-related potentials in an olfactory change detection task in twenty-four healthy adults and compared the measured activation to that found during passive olfactory stimulation. During the early olfactory post-processing phase, we found a sustained negativity over bilateral frontotemporal areas in the passive perception condition which was enhanced in the active memory task. There was no significant lateralization in either experimental condition. During the maintenance interval at the end of the delay period, we still found sustained activation over bilateral frontotemporal areas which was more negative in trials with correct - as compared to incorrect - behavioural responses. This was complemented by a general significantly stronger frontocentral activation. Summarizing, we were able to show that olfactory short term memory involves a parallel sequence of activation as found in other sensory modalities. In addition to olfactory-specific frontotemporal activations in the memory encoding phase, we found slow cortical potentials over frontocentral areas during the memory maintenance phase indicating the activation of a supramodal memory maintenance system. These findings could represent the neurophysiological underpinning of the 'olfactory flacon', the olfactory counter-part to the visual sketchpad and phonological loop embedded in Baddeley's working memory model.

Published
2013

319. QUALITY OF LIFE AND TREATMENT SATISFACTION IN PATIENTS WITH TYPE 1 DIABETES: A COMPARISON BETWEEN CONTINUOUS SUBCUTANEOUS INSULIN INJECTION AND MULTIPLE DAILY INJECTIONS

Author

Nicolucci A, Maione A, Franciosi M, Amoretti R, Busetto R, Capani F, Bruttomesso D, Di Bartolo P, Girelli A, Leonetti F, Morviducci L, Ponzi P, VitacolonnaE on behalf of the EQuality Study Group:LV Cassano, N. Tota Ospedale Generale Regionale Miulli, Acquaviva delle Fonti, V. Cherubini, A. Iannilli Università Politecnica di Ancona, AO G. Salesi, Ancona, A. Corsi, P. Ponzani UOC Genova Ponente, SO La Colletta, Arenzano, V. Montani, P. Di Berardino PO di Atri, M. Velussi Casa di Cura Pineta del Carso, Aurisina, F. Giorgino, V. Gigantelli Università degli Studi di Bari, G. Beltramello, A. Pianta CAD Bassano Bassano del Grappa, R. Trevisan, G. Lepore Ospedali Riuniti di Bergamo, G. Forlani, G. Marchesini Università degli Studi di Bologna, D. Crazzolara, M. Marchesi Ospedale di Bolzano, E. Zarra, B. Agosti Spedali Civili di Brescia, G. Careddu Ospedale SS Prosperie Caterina, Camogli, L. Tomaselli, R. Vigneri Ospedale Garibaldi Nesima, Catania, M. Agrusta, V. Di Blasi PO di Cava dei Tirreni, S. Tumini, MT Anzellotti / E. Vitacolonna, F. Capani Università G. D’Annunzio, Chieti e. Pescara, P. Ruggeri Azienda Istituti Ospedalieri, Cremona, P. Foglini, M. Rossana Ospedale A. Murri, Fermo, S. Toni, MF Reali AO Universitaria degli Studi Meyer, Firenze, M. Nizzoli, S. Aquati Ospedale Morgagni, Forlì, G. d'Annunzio, N. Minuto Istituto G. Gaslini, Genova, L. Cataldi, C. Bordone AO Università San Martino, R. Iannarelli, F. Sciarretta PO San Salvatore, L'Aquila, M. Tagliaferri, MA Lezzi Ospedale G. Vietri, Larino, L. Sciangula, A. Ciucci Ospedale di Mariano Comense, M. Bonomo, E. Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G. Mariani, P. Colapinto AO San Carlo Borromeo, G. Testori, P. Rampini AO Fatebenefratelli e. Oftalmico, R. Bonfanti, F. Meschi / G. Galimberti, A. Laurenzi Istituto Scientifico Ospedale San Raffaele, A. Veronelli, C. Mauri Ospedale San Paolo, C. Tortul, AM Cernigoi Ospedale San Paolo, Monfalcone, ME De Feo, M. Piscopo AORN A. Cardarelli, Napoli, G. Annuzzi, L. Bozzetto / A. Franzese, P. Buono / S. Turco, AA Turco AOU Università Federico II, F. Prisco, Seconda Università di Napoli, M. Trovati, P. Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S. Costa, M. Dal Pos Università degli Studi di Padova, V. Provenzano, L. Strazzera Ospedale Civico di Partitico, Palermo, G. Ridola Poliambulatorio Oreto Guadagna, E. Torlone, M. Orsini Federici Università degli Studi di Perugia, A. Bertolotto, M. Aragona AO Universitaria Pisana, Pisa, P. Di Bartolo, F. Pellicano AUSL Provincia di Ravenna, V. Manicardi, M. Michelini Ospedale di Montecchio, Reggio Emilia, M. Parenti, AC Babini Ospedale degli Infermi, Rimini, P. Borboni, A. Di Flaviani / ML Manca Bitti, S. Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A. Clementi, C. Tubili – AO San Camillo Forlanini, C. Suraci, S. Carletti Ospedale Sandro Pertini, ASL RMB, A. Moretti, M. Maiello F. Leonetti, VC Iannucci N. Sulli, B. Shashaj Università La Sapienza, Policlinico Umberto I, D. Fava, F. Massimiani AO S. Giovanni Addolorata, P. Pozzilli, S. Manfrini Università Campus Bio Medico, S. Manfrini, C. Landi ASUR Marche, Zona Territoriale n. 4, Senigallia, I. Tanganelli Università degli Studi di Siena, G. Grassi, M. Tomelini ASO San Giovanni Battista di Torino, R. De Luca, L. Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R. Candido, E. Manca ASS 1 Triestina, Trieste, L. Tonutti, C. Noacco AO Universitaria, Udine, I. Franzetti, P. Marnini AO Universitaria, Varese, IAFUSCO, Dario, Nicolucci, A, Maione, A, Franciosi, M, Amoretti, R, Busetto, R, Capani, F, Bruttomesso, D, Di Bartolo, P, Girelli, A, Leonetti, F, Morviducci, L, Ponzi, P, VitacolonnaE on behalf of the EQuality Study Group:LV, Cassano, N., Tota Ospedale Generale Regionale Miulli, Acquaviva delle, Fonti, V., Cherubini, A., Iannilli Università Politecnica di Ancona, AO G., Salesi, Ancona, A., Corsi, P., Ponzani UOC Genova Ponente, SO La, Colletta, Arenzano, V., Montani, P., Di Berardino PO di Atri, M., Velussi Casa di Cura Pineta del Carso, Aurisina, F., Giorgino, V., Gigantelli Università degli Studi di Bari, G., Beltramello, A., Pianta CAD Bassano Bassano del Grappa, R., Trevisan, G., Lepore Ospedali Riuniti di Bergamo, G., Forlani, G., Marchesini Università degli Studi di Bologna, D., Crazzolara, M., Marchesi Ospedale di Bolzano, E., Zarra, B., Agosti Spedali Civili di Brescia, G., Careddu Ospedale SS Prosperie Caterina, Camogli, L., Tomaselli, R., Vigneri Ospedale Garibaldi Nesima, Catania, M., Agrusta, V., Di Blasi PO di Cava dei Tirreni, S., Tumini, MT Anzellotti / E., Vitacolonna, F. Capani Università G., D’Annunzio, Chieti e., Pescara, P., Ruggeri Azienda Istituti Ospedalieri, Cremona, P., Foglini, M. Rossana Ospedale A., Murri, Fermo, S., Toni, MF Reali AO Universitaria degli Studi, Meyer, Firenze, M., Nizzoli, S., Aquati Ospedale Morgagni, Forlì, G., D'Annunzio, N. Minuto Istituto G., Gaslini, Genova, L., Cataldi, C., Bordone AO Università San Martino, R., Iannarelli, F., Sciarretta PO San Salvatore, L'Aquila, M., Tagliaferri, MA Lezzi Ospedale G., Vietri, Larino, L., Sciangula, A., Ciucci Ospedale di Mariano Comense, M., Bonomo, E., Meneghini AO Ospedale Niguarda Ca' Granda, Milano, G., Mariani, P., Colapinto AO San Carlo Borromeo, G., Testori, P. Rampini AO Fatebenefratelli e., Oftalmico, R., Bonfanti, F. Meschi / G., Galimberti, A., Laurenzi Istituto Scientifico Ospedale San Raffaele, A., Veronelli, C., Mauri Ospedale San Paolo, C., Tortul, AM Cernigoi Ospedale San, Paolo, Monfalcone, ME De, Feo, M. Piscopo AORN A., Cardarelli, Napoli, G., Annuzzi, L. Bozzetto / A., Franzese, P. Buono / S., Turco, AA Turco AOU Università Federico, Ii, F., Prisco, Iafusco, Dario, Seconda Università di, Napoli, M., Trovati, P., Massucco AS Ospedale San Luigi Gonzaga, Orbassano, S., Costa, M., Dal Pos Università degli Studi di Padova, V., Provenzano, L., Strazzera Ospedale Civico di Partitico, Palermo, G., Ridola Poliambulatorio Oreto Guadagna, E., Torlone, M., Orsini Federici Università degli Studi di Perugia, A., Bertolotto, M., Aragona AO Universitaria Pisana, Pisa, P., Di Bartolo, F., Pellicano AUSL Provincia di Ravenna, V., Manicardi, M., Michelini Ospedale di Montecchio, Reggio, Emilia, M., Parenti, AC Babini Ospedale degli, Infermi, Rimini, P., Borboni, A., Di Flaviani / ML Manca Bitti, S., Piccinini AO Universitaria Policlinico Tor Vergata, Roma, A., Clementi, C., Tubili – AO San Camillo Forlanini, C., Suraci, S., Carletti Ospedale Sandro Pertini, Asl, Rmb, A., Moretti, M. Maiello F., Leonetti, VC Iannucci N., Sulli, B., Shashaj Università La Sapienza, Policlinico Umberto, I, D., Fava, F. Massimiani AO S., Giovanni Addolorata, P., Pozzilli, S., Manfrini Università Campus Bio Medico, S., Manfrini, C., Landi ASUR Marche, Zona Territoriale n., 4, Senigallia, I., Tanganelli Università degli Studi di Siena, G., Grassi, M., Tomelini ASO San Giovanni Battista di Torino, R., De Luca, L., Corgiat Mansin Ospedale Oftalmico ASL 1, Torino, R., Candido, E., Manca ASS 1 Triestina, Trieste, L., Tonutti, C., Noacco AO Universitaria, Udine, I., Franzetti, P., Marnini AO Universitaria, and Varese

Published
2007

324. The role of socio-economic and clinical factors on HbA1c in children and adolescents with type 1 diabetes: an Italian multicentre survey

Author

Gesuita, Rosaria, primary, Skrami, Edlira, additional, Bonfanti, Riccardo, additional, Cipriano, Paola, additional, Ferrito, Lucia, additional, Frongia, Paola, additional, Iafusco, Dario, additional, Iannilli, Antonio, additional, Lombardo, Fortunato, additional, Mozzillo, Enza, additional, Paleari, Renata, additional, Rabbone, Ivana, additional, Sabbion, Alberto, additional, Salvatoni, Alessandro, additional, Scaramuzza, Andrea, additional, Schiaffini, Riccardo, additional, Sulli, Nicoletta, additional, Toni, Sonia, additional, Carle, Flavia, additional, and Cherubini, Valentino, additional

Published
2016
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327. Diabetes Incidence in 0- to 14-Year Age-Group in Italy

Author

CARLE F, GESUITA R, BRUNO G, COPPA GV, FALORNI A, LORINI R, MARTINUCCI ME, POZZILLI P, PRISCO F, SONGINI M, TENCONI MT, CHERUBINI V, THE RIDI STUDY GROUP, PIFFER S, FRANCHINI S, BIANCHI L, CERUTTI F, MERLETTI F, PAGANO G, COTELLESSA M, MINICUCCI L, BARBIERI P, D’ANNUNZIO G, BAZZANO S, TONI S, REALI MS, MEDICI A, IUGHETTI L, PREDIERI B, BALLI F, VISALLI N, SEBASTIANI L, MARIETTI G, SANTEUSANIO F, DE GIORGI G, SANTILLI E, IANNILLI A, PINELLI A, MASCIOLI G, ALTOBELLI E, CHIARELLI F, TUMINI S, IAFUSCO D, DE FELICE E, INGENITO N, CASU A, FRONGIA P, MARINARO A., DEVOTI, Gabriele, Carle, F, Gesuita, R, Bruno, G, Coppa, Gv, Falorni, A, Lorini, R, Martinucci, Me, Pozzilli, P, Prisco, F, Songini, M, Tenconi, Mt, Cherubini, V, THE RIDI STUDY, Group, Piffer, S, Franchini, S, Bianchi, L, Cerutti, F, Merletti, F, Pagano, G, Cotellessa, M, Minicucci, L, Barbieri, P, Devoti, Gabriele, D’Annunzio, G, Bazzano, S, Toni, S, Reali, M, Medici, A, Iughetti, L, Predieri, B, Balli, F, Visalli, N, Sebastiani, L, Marietti, G, Santeusanio, F, DE GIORGI, G, Santilli, E, Iannilli, A, Pinelli, A, Mascioli, G, Altobelli, E, Chiarelli, F, Tumini, S, Iafusco, D, DE FELICE, E, Ingenito, N, Casu, A, Frongia, P, and Marinaro, A.

Subjects
incidence, registry, Type 1 diabetes mellitu
Abstract

Objective. The Registry for Type 1 Diabetes Mellitus in Italy (RIDI) Study Group was established to coordinate the registries of type 1 diabetes in Italy. This report is based on 3,606 children younger than 15 years diagnosed with type 1 diabetes and prospectively registered during 1990-1999 by nine centers, covering > 35% of the Italian population. Research design and methods. Registries were pooled in four geographic macro-areas: north, central, south and insular. The completeness of registration was assessed by the capture-recapture method. Poisson regression analysis was used to evaluate temporal trend in incidence. Results. Large variation in incidence were confirmed not only between Sardegna and the mainland but also among peninsular areas. In Sardegna, there was an excess of boys (the boy-to-girl incidence ratio was 1.4). The overall incidence showed average increases of 3.6% (p

Published
2004

329. The functional neuroanatomy of odor evoked autobiographical memories cued by odors and words

Author

Johan Willander, Han-Seok Seo, Johannes Gerber, Thomas Hummel, Jonas Persson, Artin Arshamian, Emilia Iannilli, and Maria Larsson

Subjects
Adult, Male, medicine.medical_specialty, Cross-modal reactivation, Multiple trace theory, Memory, Episodic, Cognitive Neuroscience, Precuneus, Hippocampus, Experimental and Cognitive Psychology, Audiology, Young Adult, Behavioral Neuroscience, Fmri, Image Processing, Computer-Assisted, Reaction Time, medicine, Humans, Imagery, Episodic memory, Cued speech, Analysis of Variance, Recall, Autobiographical memory, Olfactory Pathways, Olfactory Perception, Magnetic Resonance Imaging, Oxygen, medicine.anatomical_structure, Odor, Memory retrieval, Odorants, Female, Cues, Psychology, Photic Stimulation, psychological phenomena and processes, Cognitive psychology
Abstract

Behavioral evidence indicates that odor evoked autobiographical memories (OEAMs) are older, more emotional, less thought of and induce stronger time traveling characteristics than autobiographical memories (AMs) evoked by other modalities. The main aim of this study was to explore the neural correlates of AMs evoked by odors as a function of retrieval cue. Participants were screened for specific OEAMs and later presented with the odor cue and its verbal referent in an fMRI paradigm. Because the same OEAM was retrieved across both cue formats (odor and word), potential cue dependent brain activations were investigated. The overall results showed that odor and word cued OEAMs activated regions typically associated with recollection of autobiographical information. Although no odors were presented, a verbal cuing of the OEAMs activated areas associated with olfactory perception (e.g., piriform cortex). However, relative to word cuing, an odor cuing of OEAMs resulted in more activity in MTL regions such as the parahippocampus, and areas involved in visual vividness (e.g., occipital gyrus and precuneus). Furthermore, odor cues activated areas related to emotional processing, such as limbic and tempopolar regions significantly more. In contrast, word cues relative to odor cues recruited a more widespread and bilateral prefrontal activity. Hippocampus activity did not vary as function of the remoteness of the memory, but recollection of OEAMs from the 1st vs the 2nd decade of life showed specific activation in the right OFC, whereas the 2nd reflected a higher activation in the left inferior frontal gyrus.

Published
2013
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330. Parametrical modulation analysis: habituation process in the brain

Author

Andrä, K., Sinding, Charlotte, Iannilli, Emilia, Hummel, Thomas, and ProdInra, Archive Ouverte

Subjects
[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, education, social sciences, humanities, geographic locations, health care economics and organizations
Abstract

Parametrical modulation analysis: habituation process in the brain. Congress of the Association for Olfactory and Gustology

Published
2013

333. Cross-modal integration of emotions in the chemical senses

Author

Catherine Rouby, Emilia Iannilli, Thomas Hummel, Moustafa Bensafi, Valentin A. Schriever, Johannes Gerber, Johan Poncelet, Han-Seok Seo, Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Smell & Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, and Technische Universität Dresden = Dresden University of Technology (TU Dresden)

Subjects
emotion, congruency, Olfaction, Stimulus (physiology), 050105 experimental psychology, lcsh:RC321-571, Anterior cingulate gyrus, [SCCO]Cognitive science, 03 medical and health sciences, Behavioral Neuroscience, Neural activity, 0302 clinical medicine, medicine, Psychophysics, trigeminal, 0501 psychology and cognitive sciences, Original Research Article, Chemical senses, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, ComputingMilieux_MISCELLANEOUS, Biological Psychiatry, fMRI, 05 social sciences, Human brain, Psychiatry and Mental health, Neuropsychology and Physiological Psychology, medicine.anatomical_structure, Neurology, Neural processing, Psychology, Neuroscience, psychological phenomena and processes, 030217 neurology & neurosurgery, olfaction
Abstract

Although the brain structures involved in integrating odorant and trigeminal stimuli are well-documented, there is still a need to clarify (1) how emotional response is represented in the human brain during cross-modal interaction between odors and trigeminal stimuli, and (2) whether the degree of congruency between the two types of stimuli influences these emotional responses and their neural processing. These questions were explored combining psychophysics, event-related potentials (ERP) and fMRI in the same group of 17 subjects under a “congruent condition” (intranasal carbon dioxide mixed with the smell of orange, a combination found in soda drinks, for example), and an “incongruent condition” (intranasal carbon dioxide mixed with the smell of rose, a combination not encountered in everyday life). Responses to the 3 constituent stimuli (carbon dioxide, orange, and rose) were also measured. Hedonic and intensity ratings were collected for all stimulations. The congruent bimodal stimulus was rated as more pleasant than the incongruent. This behavioral effect was associated with enhanced neural activity in the hippocampus and anterior cingulate gyrus, indicating that these brain areas mediate reactivation of pleasant and congruent olfactory-trigeminal associations.

Published
2013
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335. Cytoplasmic TERT Associates to RNA Granules in Fully Mature Neurons: Role in the Translational Control of the Cell Cycle Inhibitor p15INK4B

Author

Francesca Iannilli, Claudia Bagni, Francesca Zalfa, Carlos G. Dotti, Annette Gärtner, and Di Cunto, Ferdinando

Subjects
Cell division, Gene Expression, lcsh:Medicine, Biology, Biochemistry, Mice, Molecular Cell Biology, Genetics, Animals, Telomerase reverse transcriptase, Rats, Wistar, lcsh:Science, Telomerase, Cyclin-Dependent Kinase Inhibitor p15, Neurons, Messenger RNA, Multidisciplinary, Cell Cycle, lcsh:R, Settore BIO/13, Proteins, RNA, Neurochemistry, Translation (biology), Cell cycle, Rats, Regulatory Proteins, Telomere, Cell biology, Mice, Inbred C57BL, Protein Biosynthesis, Cellular Neuroscience, Protein Translation, lcsh:Q, RNA extraction, Cellular Types, Molecular Neuroscience, Research Article, Neuroscience
Abstract

The main role of Telomerase Reverse Transcriptase (TERT) is to protect telomere length from shortening during cell division. However, recent works have revealed the existence of a pool of TERT associated to mitochondria, where it plays a role in survival. We here show that in fully differentiated neurons the largest pool of cytoplasmic TERT associates to TIA1 positive RNA granules, where it binds the messenger RNA of the cyclin kinase inhibitor p15INK4B. Upon stress, p15INK4B and TERT dissociate and p15INK4B undergoes efficient translation, allowing its pro-survival function. These results unveil another mechanism implicated in the survival of fully differentiated neurons. © 2013 Dotti et al., Flanders Fund for Scientific Research (FWO G 0.666.10N); NEUROBRAINNET IAP 7/16; Flemish Government Methusalem Grant; Spanish Ministry of Science and Innovation Ingenio-Consolider CSD2010-00064 and SAF2010-14906.

Published
2013

337. Microplastics in Talitrus saltator (Crustacea, Amphipoda): new evidence of ingestion from natural contexts.

Author

Iannilli, Valentina, Di Gennaro, Alessia, Lecce, Francesca, Sighicelli, Maria, Falconieri, Mauro, Pietrelli, Loris, Poeta, Gianluca, and Battisti, Corrado

Subjects
CRUSTACEA, AMPHIPODA, FOURIER transform infrared spectroscopy, PLASTIC marine debris, DETRITUS, INGESTION
Abstract

Using Fourier transform infrared spectroscopy (FT-IR) measurements and comparing the spectrum peaks (range 4000-600 cm−1) with reference spectra database and instrument libraries, we observed new evidence of the ingestion of microplastic particles analyzing the digestive tracts of Talitrus saltator. Specimens, sampled in central Italy, probably ingested the particles with natural detritus. Since worldwide many species of invertebrates and vertebrates (e.g., birds) feed on Amphipoda along coastal ecosystems, we hypothesized that microplastic in these crustaceans can be accumulated along the food chain. [ABSTRACT FROM AUTHOR]

Published
2018
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338. Explorative analysis of IPA‐SPECT data through statistical inference for an automated diagnosis of glioma tumor.

Author

Ubben, Timm, Kluge, Andreas, Abolmaali, Nasreddin, and Iannilli, Emilia

Subjects
GLIOMAS, POSITRON emission tomography, MAGNETIC resonance imaging, STEREOTACTIC radiosurgery, INFERENTIAL statistics, DIAGNOSIS
Abstract

Purpose: The identification of a brain tumor imaged with PET or SPECT is usually performed with visual inspection of an expert medical clinician. However an automated diagnostic of such images hasn't been established or applied. In this study, we explored the possibility of establishing an automated statistical analysis for the diagnosis of glioma by means of IPA‐SPECT data. Methods: On the basis of a dataset of 100 patients that have undergone MRI and IPA‐SPECT acquisition, in this work, we identify an automated workflow. Three different approaches were explored: I. statistical non‐parametric mapping analysis (SnPM), II. statistical non‐parametric analysis with an increased number of permutations due to sign‐flipping function (PALM) and III. statistical parametric analysis (SPM). The automated methods were compared with the visual inspection. Results: The study proved PALM and SPM approaches to have a high diagnostic power. Compared to the parametric methods, the non‐parametric method is the mathematically correct approach for the problem in question. If we take the high resolution structural MRI information into account, the diagnostic power of PALM was not significantly inferior to the visual inspection (P = 0.5150), showing an area under the ROC curve (AUC) smaller only by less than 3%. Conclusions: The automated diagnostic method based on statistical inference, here applied to diagnose glioma tumors in IPA‐SPECT data, seems to be a promising tool that can support the visual investigation in nuclear medicine. Moreover in the foreseeable future, the presented methodology has a big potential in various application like localization of active tumor tissues in surgical resection or stereotactic radiosurgery. [ABSTRACT FROM AUTHOR]

Published
2018
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339. 38th Annual Meeting of EASD 2002

Author

Cherubini V, Carle F, Gesuita R, Bruno G, Cotellessa M, Devoti G, Falorni A, Martinucci ME, Pinelli A, Prisco F, Sondini M, Visalli N, P Barbieri, L Carpinelli, A Casu, F Cerutti, GV Coppa, D'Annunzio G, De Giorgi G, Di Meio M, Frongia P, Gentili A, Iafusco D, A Iannilli, R Lorini, G Marietti, AM Marinaro, M Mazzella, A Medici, F Merletti, G Pagano, ML Picchio, P Pozzilli, F Santeusanio, MT Tenconi, S Toni., EASD 2002 European Association for the Study of Diabetes, Cherubini, V, Carle, F, Gesuita, R, Bruno, G, Cotellessa, M, Devoti, G, Falorni, A, Martinucci, Me, Pinelli, A, Prisco, F, Sondini, M, Visalli, N, P, Barbieri, L, Carpinelli, A, Casu, F, Cerutti, Gv, Coppa, D'Annunzio, G, De Giorgi, G, Di Meio, M, Frongia, P, Gentili, A, Iafusco, D, A, Iannilli, R, Lorini, G, Marietti, Am, Marinaro, M, Mazzella, A, Medici, F, Merletti, G, Pagano, Ml, Picchio, P, Pozzilli, F, Santeusanio, Mt, Tenconi, and S, Toni.

Abstract

Background and Aims: During the last decade several studies reported an increase in the incidence of type I diabetes mellitus (TlDM). Such increase varies among the European countries in both age groups and gender. Furthermore, in some countries a rising incidence of TI DM has been reported in children

Published
2002

340. Identification of candidate children for maturity-onset diabetes of the young type 2 (MODY2) gene testing: a seven-item clinical flowchart (7-iF)

Author

Pinelli, M, Acquaviva, F, Barbetti, F, Caredda, E, Cocozza, S, Delvecchio, M, Mozzillo, E, Pirozzi, D, Prisco, F, Rabbone, I, Sacchetti, L, Tinto, N, Toni, S, Zucchini, S, Iafusco, D, Italian Study Group on Diabetes of the Italian Society of Pediatric Endocrinology, Diabetology, Biagioni, M, Carloni, I, Cester, Am, Cherubini, V, Giorgetti, C, Iannilli, A, Bruzzese, M, Mammì, F, Guasti, M, Lenzi, L, Pepe, R, Piccini, B, Benelli, M, Cadario, F, Calcaterra, V, Cerutti, F, Sicignano, S, Mammì, C, Lazzaro, N, Comberiati, P, Scaramuzza, A, Zuccotti, G, Redaelli, F, Gallo, F, Cappa, M, Patera, P, Schiaffini, R, Cardella, F, Salvo, C, De Marco, R, Chessa, M, Frongia, P, Ricciardi, Mr, Ripoli, C, Zedda, Ma, Citriniti, F, Chiarelli, F, Tumini, S, Coccioli, Ms, De Berardinis, F, Santoro, E, DE LUCA, Filippo, Lombardo, Fortunato, Salzano, Giuseppina, Felappi, B, Prandi, E, Frezza, E, Piccinno, E, Torelli, C, Zecchino, C, Galderisi, A, Monciotti, C, Ingletto, D, Kaufmann, P, Pasquino, B, Lera, R, Lucchesi, S, Perrotta, A, Salardi, S, Scipioni, M, Luceri, S, Stamati, F, Pianese, L, Piceno, A, Tomaselli, L, Vergerio, A, Casaburo, F, Cocca, A, Confetto, S, Forgione, E, Pelliccia, C, Picariello, S, Pisani, F, Piscopo, A, Villano, P, Zanfardino, A, Buono, P, Franzese, A, Nugnes, R, Valerio, G, Maffeis, C, Marigliano, M, Chiari, G, Iovene, B, Vanelli, M., Pinelli, Michele, Acquaviva, Fabio, Barbetti, F, Caredda, E, Cocozza, Sergio, Delvecchio, M, Mozzillo, Enza, Pirozzi, Daniele, Prisco, F, Rabbone, I, Sacchetti, Lucia, Tinto, Nadia, Toni, S, Zucchini, S, and Iafusco, D.

Subjects
Genetics and Molecular Biology (all), Pediatrics, medicine.medical_specialty, Science, Cost-Benefit Analysis, Decision tree, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Biochemistry, Maturity onset diabetes of the young, Settore MED/13 - Endocrinologia, Quality of life, Surveys and Questionnaires, Glucokinase, medicine, Humans, Genetic Testing, Prospective Studies, Age of Onset, Prospective cohort study, Child, Wasting, Children, Genetic testing, Retrospective Studies, Glycated Hemoglobin, Multidisciplinary, MODY2, medicine.diagnostic_test, business.industry, Decision Trees, Retrospective cohort study, medicine.disease, Test (assessment), Diabetes Mellitus, Type 2, Italy, Child, Preschool, Mutation, Quality of Life, Medicine, Female, medicine.symptom, business, gene testing, Research Article
Abstract

MODY2 is the most prevalent monogenic form of diabetes in Italy with an estimated prevalence of about 0.5-1.5%. MODY2 is potentially indistinguishable from other forms of diabetes, however, its identification impacts on patients' quality of life and healthcare resources. Unfortunately, DNA direct sequencing as diagnostic test is not readily accessible and expensive. In addition current guidelines, aiming to establish when the test should be performed, proved a poor detection rate. Aim of this study is to propose a reliable and easy-to-use tool to identify candidate patients for MODY2 genetic testing. We designed and validated a diagnostic flowchart in the attempt to improve the detection rate and to increase the number of properly requested tests. The flowchart, called 7-iF, consists of 7 binary "yes or no" questions and its unequivocal output is an indication for whether testing or not. We tested the 7-iF to estimate its clinical utility in comparison to the clinical suspicion alone. The 7-iF, in a prospective 2-year study (921 diabetic children) showed a precision of about the 76%. Using retrospective data, the 7-iF showed a precision in identifying MODY2 patients of about 80% compared to the 40% of the clinical suspicion. On the other hand, despite a relatively high number of missing MODY2 patients, the 7-iF would not suggest the test for 90% of the non-MODY2 patients, demonstrating that a wide application of this method might 1) help less experienced clinicians in suspecting MODY2 patients and 2) reducing the number of unnecessary tests. With the 7-iF, a clinician can feel confident of identifying a potential case of MODY2 and suggest the molecular test without fear of wasting time and money. A Qaly-type analysis estimated an increase in the patients' quality of life and savings for the health care system of about 9 million euros per year.

Published
2012

341. A spatiotemporal comparison between olfactory and trigeminal event-related potentials

Author

Emilia Iannilli, Artin Arshamian, Stefan Wiens, and Han-Seok Seo

Subjects
Adult, Olfactory Nerve, Cognitive Neuroscience, Olfaction, Stimulus (physiology), Somatosensory system, Primary olfactory cortex, Young Adult, Sniffing, Event-related potential, Noxious stimulus, Humans, Hydrogen Sulfide, Trigeminal Nerve, Evoked Potentials, Brain Mapping, Electroencephalography, Signal Processing, Computer-Assisted, Carbon Dioxide, Olfactory Perception, Olfactory stimulus, Stimulation, Chemical, Neurology, Female, Psychology, Neuroscience
Abstract

The present study compared the temporal and spatial aspects of human olfactory and trigeminal processing. A relatively selective trigeminal stimulus, CO2, and a relatively selective olfactory stimulus, H2S, were delivered with an olfactometer to young, healthy volunteers. The analysis was performed in a classical (5-electrode, main ERPs peaks) and modern approach (high topographical resolution, inverse solution, source localization). Results of microstate segmentation highlighted 5 maps that generally described the two processes at cerebral level. The trigeminal response differed from the olfactory response up to 300 ms after stimulus onset. In this time range, source analysis pointed out that the olfactory stimulation involved olfactory related areas, while trigeminal stimulation involved noxious/somatosensory specific brain areas. Moreover, from 300 ms on our data showed a similarity between the two processes. Statistical parametrical mapping of the differences between conditions suggested greater activation in a specific motor/sniffing network for the CO2 stimulation (probably related to a regulation of the potential noxious stimulus) and a greater activation of the ipsilateral primary olfactory cortex for H2S.

Published
2012

342. Olfactory bulb volume in smokers

Author

Nicole Reither, Emilia Iannilli, Valentin A. Schriever, Thomas Hummel, and Johannes Gerber

Subjects
Olfactory system, Adult, Male, medicine.medical_specialty, General Neuroscience, Smoking, Anatomy, Olfaction, Organ Size, Audiology, Age and sex, Olfactory Perception, Magnetic Resonance Imaging, Olfactory Bulb, Olfactory bulb, Smell, medicine.anatomical_structure, Odor, Coronal plane, Sensory Thresholds, medicine, Humans, Female, Psychology, Nose
Abstract

The study aimed to investigate the volume of the olfactory bulb in smokers. Specifically, we wanted to see whether environmental influences may exert a negative influence on OB structure. Twenty-one smokers and 59 non-smokers, matched for age and sex, underwent olfactory testing by means of the Sniffin’ Sticks testing device (measurement of odor threshold and identification abilities). In addition, they underwent an MR scan with 2-mm-thick T2-weighted fast spin-echo images without interslice gap in the coronal plane covering the anterior and middle segments of the base of the skull. Olfactory function was not different between the 2 groups; however, olfactory bulb volumes were smaller in smokers than in non-smokers (p = 0.006). The deficit seen at the level of the OB did not correlate with the duration of smoking. The current data indicate that smoking may have a negative effect on the olfactory system before this becomes obvious in terms of a decreased olfactory function.

Published
2012

343. Lateralized differences in olfactory bulb volume relate to lateralized differences in olfactory function

Author

Cornelia Hummel, Emilia Iannilli, Ilona Croy, Thomas Hummel, and Antje Haehner

Subjects
Olfactory system, Adult, Male, Adolescent, Nostril, Stimulation, Olfaction, Lateralization of brain function, Functional Laterality, Young Adult, Discrimination, Psychological, medicine, Image Processing, Computer-Assisted, Humans, Child, Aged, General Neuroscience, Odor discrimination, Anatomy, Olfactory Pathways, Middle Aged, Magnetic Resonance Imaging, Olfactory Bulb, Olfactory bulb, Smell, medicine.anatomical_structure, Odor, Sensory Thresholds, Odorants, Female, Psychology
Abstract

The present study aimed to investigate whether side differences in olfactory bulb (OB) volume correlate to respective differences in olfactory function. In a total of 164 healthy volunteers volumetric measures of the OBs were performed plus lateralized measurements of odor thresholds and odor discrimination. Side differences were defined as 10% difference between the left and right OB. In 39 cases volumes on the right side were larger than on the left side, whereas in 29 cases it was the other way around. Subjects with larger right-sided OB volumes were found to be more sensitive to odorous stimulation of the right as compared to the left nostril in terms of odor thresholds and odor detection; higher sensitivity of the left nostrils (decreased odor threshold) was observed in individuals with larger OB volumes on the left side. These data appear to suggest that OB volume may be partly dependent on lateralized influences on the olfactory system, reflecting its lateralized organization.

Published
2012

344. Dissociated Representations of Pleasant and Unpleasant Olfacto-Trigeminal Mixtures: An fMRI Study

Author

Catherine Rouby, Han-Seok Seo, Thomas Hummel, Moustafa Bensafi, Johan Poncelet, Johannes Gerber, Emilia Iannilli, Neurosciences Sensorielles Comportement Cognition, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Smell & Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, and Technische Universität Dresden = Dresden University of Technology (TU Dresden)

Subjects
Cingulate cortex, Male, Pleasure, Anatomy and Physiology, genetic structures, Caudate nucleus, lcsh:Medicine, Social and Behavioral Sciences, Biochemistry, [SCCO]Cognitive science, Superior temporal gyrus, 0302 clinical medicine, Image Processing, Computer-Assisted, Psychology, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Multidisciplinary, medicine.diagnostic_test, Crossmodal, 05 social sciences, fMRI, Brain, Neurochemistry, Human brain, Magnetic Resonance Imaging, Sensory Systems, medicine.anatomical_structure, Sensory Perception, Female, Neurochemicals, psychological phenomena and processes, Research Article, Citrus sinensis, Olfactory Nerve, Cognitive Neuroscience, Neuroimaging, Biology, Rosa, behavioral disciplines and activities, 050105 experimental psychology, Neurological System, 03 medical and health sciences, Young Adult, Neuropsychology, medicine, Humans, 0501 psychology and cognitive sciences, Trigeminal Nerve, Trigeminal nerve, Olfactory System, Analysis of Variance, lcsh:R, Cognitive Psychology, Carbon Dioxide, Olfactory Perception, Odorants, lcsh:Q, Functional magnetic resonance imaging, Insula, Neuroscience, 030217 neurology & neurosurgery
Abstract

How the pleasantness of chemosensory stimuli such as odorants or intranasal trigeminal compounds is processed in the human brain has been the focus of considerable recent interest. Yet, so far, only the unimodal form of this hedonic processing has been explored, and not its bimodal form during crossmodal integration of olfactory and trigeminal stimuli. The main purpose of the present study was to investigate this question. To this end, functional magnetic resonance imaging (fMRI) was used in an experiment comparing brain activation related to a pleasant and a relatively unpleasant olfacto-trigeminal mixture, and to their individual components (CO(2) alone, Orange alone, Rose alone). Results revealed first common neural activity patterns in response to both mixtures in a number of regions: notably the superior temporal gyrus and the caudate nucleus. Common activations were also observed in the insula, although the pleasant mixture activated the right insula whereas the unpleasant mixture activated the left insula. However, specific activations were observed in anterior cingulate gyrus and the ventral tegmental area only during the perception of the pleasant mixture. These findings emphasized for the firs time the involvement of the latter structures in processing of pleasantness during crossmodal integration of chemosensory stimuli.

Published
2012
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346. Emerging effects of early environmental factors over genetic background for type 1 diabetes susceptibility: Evidence from a nationwide Italian twin study

Author

Nisticò, L, Iafusco, D, Galderisi, A, Fagnani, C, Cotichini, R, Toccaceli, V, Stazi, Ma, Study Group on Diabetes of the Italian Society of Pediatric Endocrinology, Collaborators: Cherubini V, D. i. a. b. e. t. o. l. o. g. y., Iannilli, A, Paparusso, Am, Cavallo, L, Zecchino, C, de Filippo, G, Gargantini, L, Salardi, S, Zucchini, S, Maltoni, G, Pasquino, B, Kaufmann, P, Buzi, F, Prandi, E, Gallo, F, Cicchetti, M, Castaldo, E, Citriniti, F, Chiarelli, F, Tumini, S, Di Stefano, A, Sperlì, D, De Marco, R, Banin, P, Toni, S, Lenzi, L, Del Vecchio, M, Lorini, R, D'Annunzio, G, Ingletto, D, Scaramuzza, A, Zuccotti, Gv, Chiumello, G, Meschi, F, Bonfanti, R, Frontino, G, de Luca, F, Lombardo, F, Salzano, G, Iughetti, L, Franzese, A, Buono, P, De Simone, I, Prisco, F, Cocca, A, Cadario, F, Monciotti, Cm, Savio, V, Cardella, F, Vanelli, M, Chiari, G, Errico, K, Iovane, B, Calcaterra, V, Citro, F, Cantoni, S, Marsciani, A, Cappa, M, Patera, Pi, Schiaffini, R, Sulli, N, Spoletini, M, Cerutti, Franco, Rabbone, I, Sicignano, S, Cauvin, V, Bellizzi, M, Tonini, G, Faleschini, E, Salvatoni, A, Pinelli, L, Maffeis, C, Contreas, G., Nisticò, L, Iafusco, D, Galderisi, A, Fagnani, C, Cotichini, R, Toccaceli, V, Stazi, Ma, and the Study Group on Diabetes of the Italian Society of Pediatric Endocrinology and, Diabetology

Subjects
Adult, Male, Endocrinology, Diabetes and Metabolism, Biochemistry, Endocrinology, Clinical Biochemistry, Biochemistry (medical), medicine.medical_specialty, Adolescent, Child, Child, Preschool, Diabetes Mellitus, Type 1, Environment, Female, Humans, Infant, Kaplan-Meier Estimate, Twins, Dizygotic, Twins, Monozygotic, Genetic Predisposition to Disease, type 1 diabetes, Concordance, Population, Twins, Context (language use), Monozygotic, Internal medicine, Diabetes mellitus, Diabetes Mellitus, Dizygotic, medicine, Preschool, education, Type 1 diabetes, education.field_of_study, business.industry, medicine.disease, Twin study, Zygosity, Diabetes and Metabolism, Cohort, Environmental Exposures, business, Type 1
Abstract

Context:The incidence of type 1 diabetes has been increasing over time.Objective:We estimated the genetic and environmental components of type 1 diabetes susceptibility in a twin cohort of recent-onset cases to explore the sources of changing disease epidemiology.Design:We linked the population-based Italian Twin Registry with 14803 type 1 diabetes records from 36 pediatric diabetes care centers throughout Italy, except Sardinia, and identified 173 diabetic twins. Patients were positive for at least one autoantibody to islet cell, glutamate decarboxylase, tyrosine phosphatase, insulin, or zinc transporter 8 and were insulin dependent since their diagnosis. Zygosity was determined by DNA genotyping or by questionnaire.Outcome Measures:We estimated proband-wise concordance, cotwin recurrence risk with Kaplan-Meier method, and genetic and environmental proportions of susceptibility variance by structural equation models.Results:We recruited 104 diabetic twins (53 males) from 88 pairs (34 monozygotic, 54 dizygotic) and one triplet. The mean age at diagnosis was 8.1 yr (range 1.1-20.5 yr), and the median year of diagnosis was 2002. Proband-wise concordances were 45.5 and 16.4% in monozygotic and dizygotic pairs (P = 0.01). Recurrence risks in monozygotic and dizygotic cotwins were 37 and 12% after 10 yr from the proband's diagnosis (P = 0.005). Genetic contribution to type 1 diabetes susceptibility was 40% (95% confidence interval 8-78), and the shared and individual-specific environmental components were 51% (14-77) and 9% (4-19), respectively.Conclusions:In addition to the moderate genetic effects on type 1 diabetes susceptibility, our results draw attention to the substantial shared environmental effects, suggesting that exposures in fetal or early postnatal life may contribute to the increasing incidence of the disease.

Published
2012

348. Sporadic congenital nonautoimmune hyperthyroidism caused by P639S mutation in thyrotropin receptor gene

Author

Valentino Cherubini, Antonio Iannilli, Massimo Tonacchera, Marco Marigliano, Aldo Pinchera, Paolo Vitti, Martina Biagioni, Patrizia Agretti, and Giuseppina De Marco

Subjects
Genetic Markers, Proband, endocrine system, medicine.medical_specialty, endocrine system diseases, Thyrotropin receptor, Thyrotropin, medicine.disease_cause, Hyperthyroidism, Germline, Exon, Germline mutation, Internal medicine, Receptors, Humans, Point Mutation, Medicine, Euthyroid, Child, Preschool, Growth Disorders, Mutation, business.industry, Genetic analysis, Thyroid, Receptors, Thyrotropin, Thyrotoxicosis, medicine.anatomical_structure, Endocrinology, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business, Sporadic congenital nonautoimmune hyperthyroidism, hormones, hormone substitutes, and hormone antagonists
Abstract

Germline mutations of thyrotropin receptor (TSHR) gene determining a constitutive activation of the receptor were identified as a molecular cause of familial or sporadic congenital nonautoimmune hyperthyroidism (OMIM: 609152) (Nat Genet 7:396-401, 1994; N Engl J Med 332:150-154, 1995; Acta Endocrinol (Copenh) 100:512-518, 1982). We report the case of an Italian child subjected to the first clinical investigation at 24 months for an increased growth velocity; biochemical investigation showed high FT4 and FT3 serum values and undetectable thyrotropin in the absence of anti-thyroid antibodies; the thyroid gland was normal at ultrasound examination. Treatment with methimazole was started at the age of 30 months when her growth velocity was high and the bone age was advanced. DNA was extracted from her parents', brother's, and the patient's blood. Exons 9 and 10 of the TSHR gene were amplified by polymerase chain reaction and subjected to direct sequencing. In proband, a heterozygous substitution of cytosine to thymine determining a proline to serine change at position 639 (P639S) of the TSHR was detected while the parents and brothers of the propositus, all euthyroid, showed only the wild-type sequence of the TSHR gene. This mutation was previously described as somatic in patients affected by hyperfunctioning thyroid nodules and as germline in a single Chinese family affected by thyrotoxicosis and mitral valve prolapse. This constitutively activating mutation is able to activate both the cyclic AMP and the inositol phosphate metabolic pathways when expressed in a heterologous system. In conclusion, we describe the first case of sporadic congenital nonautoimmune hyperthyroidism caused by de novo germinal P639S mutation of TSHR.

Published
2012

349. Taste laterality studied by means of umami and salt stimuli: an fMRI study

Author

Benno Schuster, Johannes Gerber, Emilia Iannilli, Thomas Hummel, and P. Bano Singh

Subjects
Adult, Male, Taste, Cognitive Neuroscience, Thalamus, Stimulus (physiology), Sodium Chloride, Functional Laterality, Sodium Glutamate, medicine, Humans, Prefrontal cortex, Mouth, medicine.diagnostic_test, Brain, Taste Perception, Human brain, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Laterality, Female, Gustatory cortex, Functional magnetic resonance imaging, Psychology, Neuroscience
Abstract

Aim of the present study was to investigate laterality of the gustatory system in the human brain for the taste qualities elicited by MSG (monosodium glutamate) and NaCl (sodium chloride). A total of 23 subjects participated in a block-design functional magnetic resonance imaging (fMRI) study. Liquid stimuli were presented at supra-threshold concentrations and delivered by means of a computer controlled gustometer. Left and right sides of the mouth were stimulated separately in order to correlate statistical parametrical maps to both the site of the stimulus and the specific taste quality. Following the effects of the site of stimulation through primary and secondary gustatory cortices an effort was made to explore the laterality of the gustatory pathways. Our results showed for both tastants a predominance of ipsilateral connections at the thalamus level. Insula left and right regions were both involved for both tastants. In these regions we found a high proportion of ipsilateral connection again for both the tastants. Considering orbitofrontal/prefrontal cortex, left-sided stimulation with NaCl or MSG produced left-sided activation of the orbito-frontal cortex clearly indicating the presence of an ipsilateral path. Finally, the hypothesis of frontal operculum as primary gustatory cortex and lateral prefrontal cortex as secondary was also supported by the results from dynamic causal modeling.

Published
2011

350. Segregation of gustatory cortex in response to salt and umami taste studied through event-related potentials

Author

Preet Bano Singh, Thomas Hummel, and Emilia Iannilli

Subjects
Adult, Male, Taste, Monosodium glutamate, Stimulation, Umami, Stimulus (physiology), chemistry.chemical_compound, Young Adult, Discrimination, Psychological, Parietal Lobe, Humans, Evoked potential, Evoked Potentials, Cerebral Cortex, General Neuroscience, Taste Perception, Middle Aged, Frontal Lobe, Electrophysiology, chemistry, Female, Gustatory cortex, Psychology, Neuroscience
Abstract

In this study, we report gustatory event-related potentials in response to stimulation with monosodium glutamate (MSG) and salt (NaCl). We investigated differences in event-related potential related to stimulus quality, stimulus concentration, cortical topography, and participants' sex. Our results showed that amplitudes P1N1 and N1P2 were significantly larger in response to stimulation with NaCl compared with stimulation with MSG and the topographical distribution of amplitudes varied significantly for the two stimuli. In addition, responses were significantly larger in the right hemisphere compared with the left hemisphere for both stimuli, suggesting right hemispheric dominance for gustatory processing. In conclusion, this study shows significant differences in cerebral processing of MSG and NaCl in the human brain.

Published
2011

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