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928 results on '"Hamilton-Dutoit, Stephen"'

301. Functional Polymorphisms in UDP-Glucuronosyl Transferases and Recurrence in Tamoxifen-Treated Breast Cancer Survivors

Author

Ahern, Thomas P., primary, Christensen, Mariann, additional, Cronin-Fenton, Deirdre P., additional, Lunetta, Kathryn L., additional, Søiland, Håvard, additional, Gjerde, Jennifer, additional, Garne, Jens Peter, additional, Rosenberg, Carol L., additional, Silliman, Rebecca A., additional, Sørensen, Henrik Toft, additional, Lash, Timothy L., additional, and Hamilton-Dutoit, Stephen, additional

Published
2011
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304. Characteristics of Hodgkin's lymphoma after infectious mononucleosis.

Author

Hjalgrim, Henrik, Askling, Johan, Rostgaard, Klaus, Hamilton-Dutoit, Stephen, Frisch, Morten, Zhang, Jin-Song, Madsen, Mette, Rosdahl, Nils, Konradsen, Helle Bossen, Storm, Hans H, Melbye, Mads, Hjalgrim, Henrik, Askling, Johan, Rostgaard, Klaus, Hamilton-Dutoit, Stephen, Frisch, Morten, Zhang, Jin-Song, Madsen, Mette, Rosdahl, Nils, Konradsen, Helle Bossen, Storm, Hans H, and Melbye, Mads

Abstract

BACKGROUND: Infectious mononucleosis-related Epstein-Barr virus (EBV) infection has been associated with an increased risk of Hodgkin's lymphoma in young adults. Whether the association is causal remains unclear. METHODS: We compared the incidence rates of Hodgkin's lymphoma in two population-based Danish cohorts of patients who were tested for infectious mononucleosis: 17,045 with serologic evidence of having had acute EBV infection, and 24,614 with no such evidence. We combined the cohort of patients who had serologically verified infectious mononucleosis with a cohort of 21,510 Swedish patients with infectious mononucleosis (combined total, 38,555). Biopsy specimens of Hodgkin's lymphomas occurring during follow-up in this combined cohort were tested serologically for the presence of EBV. Using this information, we modeled the relative risk of EBV-negative and EBV-positive Hodgkin's lymphoma in different periods after the diagnosis of infectious mononucleosis and estimated the median incubation time for mononucleosis-related EBV-positive Hodgkin's lymphoma. RESULTS: Only serologically confirmed infectious mononucleosis was associated with a persistently increased risk of Hodgkin's lymphoma. Sixteen of 29 tumors (55 percent), obtained from patients with infectious mononucleosis, had evidence of EBV. There was no evidence of an increased risk of EBV-negative Hodgkin's lymphoma after infectious mononucleosis. In contrast, the risk of EBV-positive Hodgkin's lymphoma was significantly increased (relative risk, 4.0; 95 percent confidence interval, 3.4 to 4.5). The estimated median incubation time from mononucleosis to EBV-positive Hodgkin's lymphoma was 4.1 years (95 percent confidence interval, 1.8 to 8.3). CONCLUSIONS: A causal association between infectious mononucleosis-related EBV infection and the EBV-positive subgroup of Hodgkin's lymphomas is likely in young adults. Udgivelsesdato: 2003-Oct-2

Published
2003

306. A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)

Author

Enciso-Mora, Victor, primary, Broderick, Peter, additional, Ma, Yussanne, additional, Jarrett, Ruth F, additional, Hjalgrim, Henrik, additional, Hemminki, Kari, additional, van den Berg, Anke, additional, Olver, Bianca, additional, Lloyd, Amy, additional, Dobbins, Sara E, additional, Lightfoot, Tracy, additional, van Leeuwen, Flora E, additional, Försti, Asta, additional, Diepstra, Arjan, additional, Broeks, Annegien, additional, Vijayakrishnan, Jayaram, additional, Shield, Lesley, additional, Lake, Annette, additional, Montgomery, Dorothy, additional, Roman, Eve, additional, Engert, Andreas, additional, von Strandmann, Elke Pogge, additional, Reiners, Katrin S, additional, Nolte, Ilja M, additional, Smedby, Karin E, additional, Adami, Hans-Olov, additional, Russell, Nicola S, additional, Glimelius, Bengt, additional, Hamilton-Dutoit, Stephen, additional, de Bruin, Marieke, additional, Ryder, Lars P, additional, Molin, Daniel, additional, Sorensen, Karina Meden, additional, Chang, Ellen T, additional, Taylor, Malcolm, additional, Cooke, Rosie, additional, Hofstra, Robert, additional, Westers, Helga, additional, van Wezel, Tom, additional, van Eijk, Ronald, additional, Ashworth, Alan, additional, Rostgaard, Klaus, additional, Melbye, Mads, additional, Swerdlow, Anthony J, additional, and Houlston, Richard S, additional

Published
2010
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309. HLA-A alleles and infectious mononucleosis suggest a critical role for cytotoxic T-cell response in EBV-related Hodgkin lymphoma

Author

Hjalgrim, Henrik, primary, Rostgaard, Klaus, additional, Johnson, Paul C. D., additional, Lake, Annette, additional, Shield, Lesley, additional, Little, Ann-Margaret, additional, Ekstrom-Smedby, Karin, additional, Adami, Hans-Olov, additional, Glimelius, Bengt, additional, Hamilton-Dutoit, Stephen, additional, Kane, Eleanor, additional, Taylor, G. Malcolm, additional, McConnachie, Alex, additional, Ryder, Lars P., additional, Sundstrom, Christer, additional, Andersen, Paal Skytt, additional, Chang, Ellen T., additional, Alexander, Freda E., additional, Melbye, Mads, additional, and Jarrett, Ruth F., additional

Published
2010
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311. In Response

Author

Riber-Hansen, Rikke, primary, Nyengaard, Jens R., additional, Hamilton-Dutoit, Stephen J., additional, and Steiniche, Torben, additional

Published
2010
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312. Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen

Author

Lash, Timothy L., primary, Cronin-Fenton, Deirdre, additional, Ahern, Thomas P., additional, Rosenberg, Carol L., additional, Lunetta, Kathryn L., additional, Silliman, Rebecca A., additional, Hamilton-Dutoit, Stephen, additional, Garne, Jens Peter, additional, Ewertz, Marianne, additional, Sørensen, Henrik Toft, additional, and Pedersen, Lars, additional

Published
2010
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313. In situ demonstration of Epstein-Barr virus small RNAs (EBER 1) in acquired immunodeficiency syndrome-related lymphomas:correlation with tumor morphology and primary site

Author

Hamilton-Dutoit, Stephen Jacques, Raphael, M, Audouin, J, Diebold, J, Lisse, I, Pedersen, C, Oksenhendler, E, Marelle, L, and Pallesen, G

Subjects
B-Lymphocytes, Herpesvirus 4, Human, Brain Neoplasms, Lymphoma, Non-Hodgkin, Hodgkin Disease, Central Nervous System Neoplasms, Tumor Virus Infections, immune system diseases, hemic and lymphatic diseases, HIV Seropositivity, Humans, RNA, Viral, Digoxigenin, In Situ Hybridization, Lymphoma, AIDS-Related
Abstract

Some acquired immunodeficiency syndrome (AIDS)-related lymphomas (ARLs) are infected with Epstein-Barr virus (EBV), although the frequency and importance of this association is disputed. Using paraffin section RNA in situ hybridization (ISH) with digoxigenin-labeled riboprobes, we screened 16 central nervous system (CNS) non-Hodgkin's lymphomas (NHLs), 101 systemic NHLs, and 11 Hodgkin's disease cases arising in human immunodeficiency virus-seropositive individuals for EBV-encoded small RNA (EBER 1) expression, an EBV gene product transcribed in abundance during latent infection. Tumor cells contained EBV in 85 of 128 ARLs (66%), but infection rates differed with lymphoma type. EBER 1 was expressed in tumor cells in 11 of 11 Hodgkin's disease cases (100%), 15 of 16 CNS NHLs (94%), and 46 of 60 systemic immunoblast-rich/large-cell lymphomas (77%), but in only 12 of 35 Burkitt-type (small noncleaved cell) (34%) and 1 of 6 monomorphic centroblastic (diffuse large noncleaved cell) (17%) lymphomas. In most EBV-positive ARLs, all recognizable viable tumor cells expressed EBER 1. We conclude that (1) EBV infects tumor cells in all AIDS-related Hodgkin's disease cases, in virtually all primary CNS ARLs, and in most systemic immunoblast-rich/large-cell ARLs; (2) only a minority of Burkitt-type and monomorphic centroblastic lymphomas are associated with EBV; and (3) EBER-ISH is ideal for the histopathologic detection of latent EBV in routine tissue specimens.

Published
1993

321. Laser-assisted microdissection of membrane-mounted paraffin sections for polymerase chain reaction analysis:Identification of cell populations using immunohistochemistry and in situ hybridization

Author

Gjerdrum, Lise Mette, Lielpetere, Ilze, Rasmussen, Lars Melholt, Bendix, Knud, Hamilton-Dutoit, Stephen, Gjerdrum, Lise Mette, Lielpetere, Ilze, Rasmussen, Lars Melholt, Bendix, Knud, and Hamilton-Dutoit, Stephen

Abstract

Laser microbeam microdissection (LMM) is an increasingly important method for obtaining pure cell samples for genetic and proteomic analysis. Immuno-histochemistry (IHC) and in situ hybridization (ISH) are useful techniques for targeting specific cell populations for microdissection but are difficult to apply with the tissue support membranes often used during LMM. Using detection of cytokeratins and Epstein-Barr virus gene products in head and neck carcinoma as a model, we describe optimized protocols for membrane and section preparation and for low temperature antigen retrieval that allow IHC and ISH to be used reliably on membrane mounted paraffin tissue sections. Visualization of cellular targets was markedly improved by staining and this could be further improved using a variety of optical media before microdissection. Tissue fragments thus stained were suitable for subsequent polymerase chain reaction analysis of extracted DNA using standard techniques. These IHC and ISH procedures are generally applicable and will be useful for detecting a wide range of antigens and nucleic acids in paraffin sections in conjunction with LMM.

Published
2001

322. Serum YKL-40 and Interleukin 6 Levels in Hodgkin Lymphoma

Author

Biggar, Robert J., primary, Johansen, Julia S., additional, Smedby, Karin Ekström, additional, Rostgaard, Klaus, additional, Chang, Ellen T., additional, Adami, Hans-Olov, additional, Glimelius, Bengt, additional, Molin, Daniel, additional, Hamilton-Dutoit, Stephen, additional, Melbye, Mads, additional, and Hjalgrim, Henrik, additional

Published
2008
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323. Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approach

Author

van Rijk, Anke, primary, Mason, David, additional, Jones, Margaret, additional, Cabeçadas, José, additional, Crespo, Mateus, additional, Cigudosa, Juan Cruz, additional, Garcia, Juan Fernando, additional, Leoncini, Lorenzo, additional, Cocco, Mario, additional, Hansmann, Martin-Leo, additional, Mottok, Anja, additional, Copie Bergman, Christiane, additional, Baia, Maryse, additional, Anagnostou, Dimitra, additional, Pouliou, Evi, additional, Hamilton Dutoit, Stephen, additional, Hjøllund Christiansen, Mette, additional, Svenstrup Poulsen, Tim, additional, Hauge Matthiesen, Steen, additional, van Dongen, Jacques, additional, and van Krieken, J. Han, additional

Published
2008
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325. Modification of Tamoxifen Response: What Have We Learned?

Author

Lash, Timothy L., primary, Ahern, Thomas P., additional, Cronin-Fenton, Deirdre, additional, Garne, Jens Peter, additional, Hamilton-Dutoit, Stephen, additional, Kvistgaard, Marianne Ewertz, additional, Rosenberg, Carol L., additional, Silliman, Rebecca A., additional, and Sørensen, Henrik Toft, additional

Published
2008
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332. Cigarette Smoking and Risk of Hodgkin Lymphoma: A Population-Based Case-Control Study

Author

Hjalgrim, Henrik, primary, Ekström-Smedby, Karin, additional, Rostgaard, Klaus, additional, Amini, Rose-Marie, additional, Molin, Daniel, additional, Hamilton-Dutoit, Stephen, additional, Schöllkopf, Claudia, additional, Chang, Ellen T., additional, Ralfkiaer, Elisabeth, additional, Adami, Hans-Olov, additional, Glimelius, Bengt, additional, and Melbye, Mads, additional

Published
2007
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337. HIV-associated lymphoma:histopathology and association with Epstein-Barr virus genome related to clinical, immunological and prognostic features

Author

Pedersen, C, Gerstoft, J, Lundgren, J D, Skinhøj, P, Bøttzauw, J, Geisler, C, Hamilton-Dutoit, Stephen Jacques, Thorsen, S, Lisse, I, and Ralfkiaer, E

Subjects
Adult, Male, Herpesvirus 4, Human, Genome, Viral, Middle Aged, Prognosis, Antigens, CD4, immune system diseases, hemic and lymphatic diseases, DNA, Viral, Humans, Female, Aged, Lymphoma, AIDS-Related
Abstract

All 51 cases of HIV-related malignant lymphoma in Denmark diagnosed from 1983 to 1989 were reviewed. There were 12 Burkitt-type lymphomas, 30 immunoblast-rich lymphomas and 9 other lymphomas. Patients with immunoblast-rich lymphomas had significantly lower CD4 cell counts (median 60 vs. 188 x 10(6)/l, P less than 0.05), and more often a history of previous AIDS-defining illnesses (50% vs. 0%, P less than 0.005), compared with patients with Burkitt-type lymphomas. Epstein-Barr virus (EBV) DNA was demonstrated in 14 of 19 immunoblast-rich tumours, and in 2 of 7 Burkitt-type lymphomas (P = 0.10). Compared with EBV DNA-negative tumours EBV DNA-positive tumours were associated with lower CD4 cell counts (median 39 vs. 188 x 10(6)/l, P = 0.01). It is concluded that two main types of HIV-related malignant lymphoma exist. One is associated with severe immunosuppression, is often of immunoblast-rich morphology, and may be linked to EBV, whereas the other may occur in the absence of immunosuppression, is often of Burkitt-type morphology, and is probably not linked to EBV. In addition to these two main types, other non-Hodgkin lymphomas and Hodgkin's disease do occur.

Published
1991

338. The Oncoprotein LMO2 Is Expressed in a Germinal Center B-Cell-Associated Pattern and Predicts Survival in Patients with Diffuse Large B-Cell Lymphoma.

Author

Natkunam, Yasodha, primary, Hsi, Eric D., primary, Hans, Christine, primary, Zhao, Shuchun, primary, Taidi, Behnaz, primary, Chen, Jun, primary, Mason, David Y., primary, Marafioti, Teresa, primary, Jones, Margaret, primary, Pohlman, Brad, primary, Hammer, Anne S., primary, Hamilton-Dutoit, Stephen, primary, Avigdor, Abraham, primary, Schiby, Ginette, primary, Nagler, Arnon, primary, Byrne, Gerald E., primary, Levy, Ronald, primary, and Lossos, Izidor S., primary

Published
2006
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340. Specificity of monoclonal antibody HML-1

Author

Pallesen, G and Hamilton-Dutoit, Stephen Jacques

Subjects
Leukemia, Hairy Cell, Antibody Specificity, Antigens, Neoplasm, Tumor Markers, Biological, T-Lymphocytes, Antibodies, Monoclonal, Ascitic Fluid, Humans
Published
1990

350. Author reply

Author

Abrahamsen, Helene Nortvig, primary, Hamilton-Dutoit, Stephen J., additional, and Steiniche, Torben, additional

Published
2004
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