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301. Optimization of passive solar design and integration of building integrated photovoltaic/thermal (BIPV/T) system in northern housing.

Author

Ma, Li, Ge, Hua, Wang, Lin, and Wang, Liangzhu

Abstract

In the Canadian north, the cost of space heating is very high due to the harsh weather, its remoteness, lack of transportation, and dependency on the high cost of fossil fuel imported from the South. Since the North has an abundance of solar energy, significant energy savings with some added construction cost in houses could be achieved by applying high-performance building envelopes and solar design strategies. The objective of this paper is to investigate the potential of both passive and active solar design strategies in improving the energy efficiency of northern housing. Firstly, a reference house representing a typical single-family home in the North is modeled using EnergyPlus, and the key passive design parameters are optimized to minimize life-cycle cost. Then, the air-based building integrated photovoltaic/thermal (BIPV/T) system is applied to the optimized house and integrated with HVAC systems. It is found that optimal passive solar design can reduce the heating energy demand by 42% with an incremental cost of 8% for Yellowknife and by 27% without incurring an incremental cost for Kuujjuaq. Integrating BIPV/T with HVAC systems can reduce the defrost time of heat recovery ventilator (HRV), extend the working hours and improve the COP of air source heat pump (ASHP). The reduction in the total energy consumption is in the range of 1.4%–3.0% by integrating HRV and 0.3%–0.6% by integrating ASHP due to the mis-match of solar availability and heating energy demand. To maximize the utilization of solar energy available, the optimal use of thermal energy recovered from BIPV/T system in northern housing requires further investigation. [ABSTRACT FROM AUTHOR]

Published
2021
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305. Model-Based Design Methodology for Sampling Rate Converter

Author

Nie Yang, Jing Li-li, and Ge Hua

Subjects
Scheme (programming language), General Computer Science, Computer science, 020208 electrical & electronic engineering, Real-time computing, 020207 software engineering, 02 engineering and technology, Test code, Flow (mathematics), Filter (video), Model-based design, 0202 electrical engineering, electronic engineering, information engineering, Electronic engineering, Code (cryptography), Polyphase system, Engineering design process, computer, computer.programming_language
Abstract

The design of high-speed sampling rate converter in multi-rate system is a very complicated problem. The traditional development flow is not simply low efficiency, and but also is difficult to implementation. This paper presents a development flow by modelbased design to simplify the design process, to improve work efficiency. Sampling rate converter is designed by a hybrid scheme using polyphase filter and Farrow filter structure. Through the development flow of model-based design, circuit modeling is very easy to do, and the RTL code and test code are automatically generated. The simulation results show that this method can greatly reduce the system consumption and promote the performance of the system.

Published
2016
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306. Model-Based Design Methodology for Digital Up and Down Conversion of Software Defined Radio

Author

Zhao Peng-yu, Nie Yang, Ge Hua, and Jing Li-li

Subjects
General Computer Science, business.industry, Computer science, Reliability (computer networking), 020208 electrical & electronic engineering, Design flow, Process (computing), Down conversion, 020206 networking & telecommunications, 02 engineering and technology, Software-defined radio, System model, Embedded system, Model-based design, 0202 electrical engineering, electronic engineering, information engineering, Code (cryptography), business
Abstract

This paper proposes an efficient implementation of digital up and down conversion for Software Defined Radio (SDR) using Model-Based Design (MBD). In particular, a novel flow for designing digital up and down conversion is detailed. Using MBD, a system model is at the center of the development process, from requirement development, through design, implementation, and testing. Using MBD, code can be automatically generated for system and create test benches for system verification, which is saving time and avoiding the introduction of manually coded errors. Design example shows that the proposed method can greatly reduce the complexity of digital up and down conversion while providing the efficient and reliability of design flow.

Published
2016
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307. Homochiral Dysprosium Phosphonate Nanowires: Morphology Control and Magnetic Dynamics.

Author

Weng, Guo‐Guo, Huang, Xin‐Da, Hu, Rui, Bao, Song‐Song, Zou, Qian, Wen, Ge‐Hua, Zhang, Yi‐Quan, and Zheng, Li‐Min

Subjects
MAGNETIC control, NANOWIRES, DYSPROSIUM, CHIRALITY of nuclear particles, SINGLE molecule magnets, COORDINATION polymers, PHYSICAL mobility, MAGNETISM
Abstract

Controllable synthesis of uniformly distributed nanowires of coordination polymers with inherent physical functions is highly desirable but challenging. In particular, the combination of chirality and magnetism into nanowires has potential applications in multifunctional materials and spintronic devices. Herein, we report four pairs of enantiopure coordination polymers with formulae S‐, R‐Dy(cyampH)3 ⋅ CH3COOH ⋅ 2H2O (S‐1, R‐1), S‐, R‐Dy(cyampH)3 ⋅ 3H2O (S‐2, R‐2), S‐, R‐Dy(cyampH)2(C2H5COO) ⋅ 3H2O (S‐3, R‐3) and S‐, R‐Dy(cyampH)3 ⋅ 0.5C2H5COOH ⋅ 2H2O (S‐4, R‐4) [cyampH2=S‐, R‐(1‐cyclohexylethyl)aminomethylphosphonic acids], which were obtained depending on the pH of the reaction mixtures and the specific carboxylic acid used as pH regulator. Interestingly, compounds 3 were obtained as superlong nanowires, showing 1D neutral chain structure which contains both phosphonate and propionate anion ligands. While compounds 1, 2 and 4 appeared as block‐like crystals, superhelices and nanorods, respectively, and exhibited similar neutral chain structures containing only phosphonate ligand. Slow magnetization relaxation characteristic of single‐molecule magnet (SMM) behavior was observed for compounds S‐1 and S‐3. Theoretical calculations were performed to rationalize the magneto‐structural relationships. [ABSTRACT FROM AUTHOR]

Published
2021
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308. Analysis of the water level drop in the tail zone of the largest tributary of Poyang Lake, China.

Author

Ge, Hua and Zhu, Lingling

Abstract

In recent years, the tail zone of the largest tributary of the largest freshwater lake, Poyang Lake in China, has been challenged by serious water scarcity caused by the drop of the water level during dry season. It is difficult to establish effective remedial measures because of the lack of research regarding the causes of the water level drop. Therefore, this phenomenon and its causes were analyzed in this study. First, a series of daily discharge and water level data from six hydrological and water level stations that has been recorded since the 1950s was used to determine the historical trends in the dry water level using the Mann–Kendall test. Based on the combination of topographic data of typical cross section and classic water conservancy equations, the causes of the water level decrease were studied. The results show that the water level drop in this region was not notable until 2003. Subsequently, continuous deterioration became noticeable. Influenced by various factors, the cumulative water level drop in the dry season reached 4.06 m. This demonstrates the weak correlation between the water level drop and inflow. Instead, the water level decrease was mainly affected by the riverbed undercutting and slightly influenced by changes of the water level in the four lower branches. Effective alleviation strategies should include the strict limitation of the incision of the riverbed and increase in the downstream water level. [ABSTRACT FROM AUTHOR]

Published
2021
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309. Scenarios of energy reduction potential of zero energy building promotion in the Asia-Pacific region to year 2050

Author

Wei Feng, Andreas K. Athienitis, Dong woo Cho, Wei Xu, Edward Mazria, Masaya Okumiya, Ke Wang, Usha Iyer-Raniga, Yanjie Lyu, Gyuyoung Yoon, Ge Hua, and Shicong Zhang

Subjects
020209 energy, Population, 02 engineering and technology, Industrial and Manufacturing Engineering, Article, Asia-pacific region, 020401 chemical engineering, 0202 electrical engineering, electronic engineering, information engineering, Economics, Production (economics), 0204 chemical engineering, Electrical and Electronic Engineering, education, Civil and Structural Engineering, Consumption (economics), education.field_of_study, Zero-energy building, Future forecast, business.industry, Mechanical Engineering, Energy mix, Building and Construction, Environmental economics, Pollution, Renewable energy, General Energy, Purchasing power parity, Energy intensity, business, Zero energy building
Abstract

Building energy consumption in the Asia-Pacific region continues to rise. It is important to understand the energy use and future trends of 21 members of Asia-Pacific Economic Cooperation (APEC) and to find more effective ways to achieve APEC’s dual goals of reducing energy intensity by 45% of 2005 levels by 2035 and doubling the share of renewable energy in the energy mix between 2010 and 2030. Recently, promoting building toward ultra-low energy, nearly zero energy and zero energy is becoming a consensus trend. This paper aims to explore how zero energy building promotion could influence the total energy demand in the mid to long term. An EUPP (Economic, Urbanization, Population and Purchasing power parity) model was established to show the relationship between building energy consumption and its influencing factors, and the potential development path of building energy consumption in APEC was predicted by using the model. The results show that in the Business As Usual (BAU) model, building energy demand will increase from 1387.4 Mtoe in 2016 to 2456.8 Mtoe in 2050 while in the CAP model, building energy demand will be constrained to under 2000 Mtoe before 2050. In the ZEB promotion model, 897.8 to 1945.3 Mtoe could be saved separately. The share of end demand supplied by onsite renewable energy production could reach 11%–54%. The building sector has the potential to become the largest contributor to achieve the APEC energy goal and thus to the climate change goal., Highlights • A long-term building energy intensity prediction model is established. • Building demand in APEC region will reach 2456.8 Mtoe in 2050 in BAU Model. • 897.8 to 1945.3 Mtoe could be saved separately under various ZEB scenarios. • Energy consumption decreases only if more than 40% of buildings are nearly Zero.

Published
2020

310. Application of Mathematical Model in Water Conservancy Project at Confluence Section

Author

Chun-yan Deng, Rui Long, Junqiang Xia, and Ge Hua

Subjects
Section (archaeology), Confluence, Civil engineering, Geology
Abstract

The new construction of the wading project at the confluence section, where the flow condition is rather complex, has definitely to take more influencing factors in consideration. In order to investigate quantitatively the effect of secondary flows on the transport of flow and sediment in a sharply curved channel, the landscape project at the Yibin reach was taken as an example, and the 2D Mathematical Model was used to simulate the distributions of flow factors. As the predicted project is located at the confluence of the Three Rivers, the left banks of the Minjiang River and the Yangtze River, the complexity of the inflow and outflow conditions was considered during the study, and different research schemes were compared. Result of this research can be valuable reference for similar projects.

Published
2020
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311. Selection of moisture reference year for freeze-thaw damage assessment of historic masonry walls under future climate: A simulation-based approach.

Author

Sahyoun, Sahar, Ge, Hua, and Lacasse, Michael A.

Subjects
BUILDING performance, BUILDING envelopes, RETROFITTING of buildings, FREEZE-thaw cycles, MASONRY, RETROFITTING
Abstract

Today, there is an increased research effort on improving energy efficiency in heritage buildings through retrofit measures. Hygrothermal simulations tools are often used to assess the long-term performance of building envelopes and determine whether they are suitable for interior insulation. To reduce the high computation time and cost incurred with these simulations, a moisture reference year (MRY) is typically selected based on long-term annual climatic conditions. Simulation results obtained under MRYs are assumed to represent the long-term performance. However, when assessing the risk to freeze-thaw (FT) damage of historic masonry walls, methods selecting climate-based MRYs have failed to represent the actual performance – determined based on results from simulations over the 31 consecutive years. This paper attempts to find an alternative method to select MRYs, based on the hygrothermal simulations of specific constructions. First, a parametric analysis was proposed to identify the parameters that have the greatest influence on FT damage. Then, simulations are performed for a continuous 31-year period and for each single year. A comparison of their results suggests that there is no accumulative effect on the annual freeze-thaw cycles; and therefore, MRYs can be selected as the single year with the 93rd percentile FT damage severity or the worst year commonly found between masonry walls pre and post retrofit. The application of MRYs was then verified for different insulation types and thicknesses. Results showed that simulation-based MRYs are construction and orientation dependent; however, they are reliable to use for retrofitting design decision making. • Simulation-based approach developed for moisture reference year specific to freeze-thaw damage. • Single-year simulation can be used to select MRY for assessing long-term freeze-thaw damage risk. • Simulation-based MRY verified for various internally insulated historic masonry walls. [ABSTRACT FROM AUTHOR]

Published
2024
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317. Guideline on design for durability of building envelopes

Author

Lacasse, Michael A., Ge, Hua, Hegel, Mark, Jutras, Robert, Laouadi, Aziz, Sturgeon, Gary, and Wells, John

Abstract

This document provides guidance on the use of heat, air and moisture transfer (hereinafter referred to as hygrothermal) models to provide results from which to infer the durability of building elements, which include building envelope materials, components and assemblies in opaque wall systems. It is intended for use by expert practitioners who have knowledge of the use of hygrothermal models to provide results used to inform on the resilience of envelope design, have an understanding of the principles of applied building physics, and are familiar with the durability of building materials, components and assemblies.

Published
2018
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339. Data Quality Criteria for Urban Waste Management Policy-Making Using Environment-based Design*

Author

Chen, Tianyu, Yang, Jiami, Du, Wenhang, Yao, Jinli, Yan, Jun, Ge, Hua, Bhuiyan, Nadia, Zhou, Fayi, Liu, Xiao, and Zeng, Yong

Abstract

Existing data quality criteria often focus on the quality of the data itself while overlooking other aspects such as the relevance between data and downstream tasks. Furthermore, prior to data collection, policy-makers lack ground truths or labelled data, and are unable to filter data using quantitative criteria. To ensure the collection of reliable, necessary, and sufficient data for policy-making, this study derives a data-driven policy-making framework from Environment-based Design (EBD). Based on the framework, we present five qualitative criteria called RULER (Reliable, Uncoupled, Lifecycle, Environment, Relevant) to evaluate and filter data for data-driven waste management and policy-marking. A case study from Beijing, China shows how to apply these criteria, through which a relatively reliable, sufficient, and necessary data list is given as result.

Published
2022
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340. Cobalt(II)‐dianthracene Frameworks: Assembly, Exfoliation and Properties.

Author

Zou, Qian, Bao, Song‐Song, Huang, Xin‐Da, Wen, Ge‐Hua, Jia, Jia‐Ge, Wu, Lan‐Qing, and Zheng, Li‐Min

Subjects
COBALT, NANOSTRUCTURED materials, PHASE transitions, PHOSPHONATES, METAL-organic frameworks
Abstract

Metal‐organic frameworks containing responsive organic linkers are attractive for potential applications in sensors and molecular devices. Herein we report three cobalt(II) phosphonates incorporating responsive dianthracene linkers, namely, Co2(amp2H2)2(H2O)4 ⋅ 6H2O (MDAF‐1), Co2(amp2)(H2O)4 ⋅ 2H2O (MDAF‐2) and Co(amp2H2) ⋅ 2H2O ⋅ 0.5DMF (MDAF‐3), where amp2H4 is pre‐photodimerized 9‐anthrylmethylphosphonic acid. MDAF‐1 shows a layer structure in which dinuclear Co2(PO3H)2 units are inter‐connected by dianthracene ligands. In MDAF‐2 and MDAF‐3, inorganic chains of corner‐sharing {CoO4} (or {CoO6}) and {PO3C} are cross‐linked by dianthracene ligands into 3D frameworks. All compounds underwent thermo‐induced phase transitions, first the de‐solvation and then the de‐dimerization of dianthracene (as well as the release of the remaining solvent molecules for MDAF‐2 and ‐3), associated with magnetic changes. MDAF‐1 can be exfoliated into single‐layer nanosheets in water which show light‐triggered luminescent changes. [ABSTRACT FROM AUTHOR]

Published
2021
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341. Prognostic role of HSPs in human gastrointestinal cancer: a systematic review and meta-analysis

Author

Ge,Hua, Yan,Yan, Guo,Lingfei, Tian,Fei, Wu,Di, Ge,Hua, Yan,Yan, Guo,Lingfei, Tian,Fei, and Wu,Di

Abstract

Hua Ge,1 Yan Yan,2 Lingfei Guo,1 Fei Tian,1 Di Wu1 1Department of Gastrointestinal Surgery, 2Quality Control Department, The First People’s Hospital of Zunyi, Zunyi Medical University, Huichuan, Zunyi, Guizhou, China Background: Heat shock proteins (HSPs) have been reported to be overexpressed in a wide range of human tumors. It has been shown that HSPs act as an oncogenic regulator and are involved in tumorigenesis. The clinical and prognostic significance of HSPs in gastrointestinal cancers (GICs) remains controversial. The aim of this study was to conduct a meta-analysis to assess the prognostic value of HSPs in GICs. Materials and methods: A literature search was performed in PubMed, Cochrane Library, Web of Science, and Embase databases. Data on the relationship between expression of HSPs and survival outcomes were extracted. Pooled hazard ratios (HRs) with 95% CI were calculated.Results: The expression of HSPs was not associated with the overall survival (OS) of GIC patients; however, it was significantly associated with worse OS for gastric cancer (GC) and colorectal cancer (CRC) patients.Conclusion: Current evidence suggests that a high level of HSPs may not be a potential marker to predict the survival rate for every type of GICs. However, the expression of HSPs may predict a poor prognosis for GC and CRC patients. Keywords: heat shock protein, gastrointestinal cancer, prognosis, meta-analysis&nbsp

Published
2018

342. Potential role of LINC00996 in colorectal cancer: a study based on data mining and bioinformatics

Author

Ge,Hua, Yan,Yan, Wu,Di, Huang,Yongsheng, Tian,Fei, Ge,Hua, Yan,Yan, Wu,Di, Huang,Yongsheng, and Tian,Fei

Abstract

Hua Ge,1,* Yan Yan,2,* Di Wu,1 Yongsheng Huang,1 Fei Tian1 1Department of Gastrointestinal Surgery, The First People’s Hospital of Zunyi, Zunyi, Guizhou, People’s Republic of China; 2Quality Control Department, The First People’s Hospital of Zunyi, Zunyi, Guizhou, People’s Republic of China *These authors contributed equally to this work Background: The clinical significance of LINC00996 in colorectal cancer (CRC) has not been verified. In the current study, the authors aimed to explore the expression of LINC00996 and its clinical significance in CRC based on the data mining of Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) datasets, as well as to elucidate the functions of its potential target genes. Materials and methods: GEO and TCGA microarray datasets were used to evaluate the LINC00996 expression and its clinical significance in CRC. LINC00996 related genes were identified by Multi Experiment Matrix, RNA-Binding Protein DataBase, and The Atlas of Noncoding RNAs in Cancer. Subsequently, they were sent to gene ontology enrichment and Kyoto Encyclopedia of Genes and Genomes pathway analysis. Results: LINC00996 is significantly decreased in CRC tissues compared with non-tumor tissues. Low level of LINC00996 is associated with remote metastasis and poor overall survival. However, LINC00996 has a minimal effect on gender, lymphatic invasion, tumor size, lymph node metastasis, and pathological stage. One hundred and forty-two LINC00996 related genes were identified; the results of functional analysis indicated that LINC00996 might repress tumorigenesis and metastasis via modulating the JAK-STAT, NF-κB, HIF-1, TLR, and PI3K-AKT signaling pathways. Conclusion: Our study demonstrates that decreased LINC00996 expression may be involved in colorectal carcinogenesis and metastasis, and the depletion of LINC00996 is associated with a poor outcome in CRC patients. Moreover, the JAK-STAT, NF-&kap

Published
2018

343. DcR3 induces proliferation, migration, invasion, and EMT in gastric cancer cells via the PI3K/AKT/GSK-3β/β-catenin signaling pathway

Author

Ge,Hua, Liang,Chaojie, Li,Zhixia, An,Dali, Ren,Shulin, Yue,Chaosen, Wu,Jixiang, Ge,Hua, Liang,Chaojie, Li,Zhixia, An,Dali, Ren,Shulin, Yue,Chaosen, and Wu,Jixiang

Abstract

Hua Ge, Chaojie Liang, Zhixia Li, Dali An, Shulin Ren, Chaosen Yue, Jixiang Wu Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China Background: Decoy receptor 3 (DcR3) has been reported to be overexpressed in a wide variety of malignancies and is correlated with tumorigenesis and progression. In gastric cancer (GC), DcR3 overexpression is associated with lymph node and distant metastasis, as well as poor prognosis. However, the functional role of DcR3 expression in GC remains elusive. Purpose: The aim of this study is to elucidate the direct role of DcR3 in regulating GC progression and metastasis and identify the potential mechanism. Methods: DcR3 expression was stably knocked down in HGC27 and MKN28 cells by transfecting the cells with DcR3 shRNA using lentiviral vector system. After the knockdown of DcR3 was confirmed, cell proliferation, colony formation, cell cycle distribution, apoptosis, cell invasion and migration were assessed in vitro. In addition, Western blot analysis was performed to evaluate the expression of downstream mediators of DcR3. Comparisons between multiple groups were performed using one-way analysis of variance (ANOVA) or unpaired Student’s t-test. Differences were considered significant at P<0.05. Results: Our findings demonstrate that DcR3 induces proliferation, migration, invasion, and promotes epithelial-mesenchymal transition (EMT) of GC cells. In addition, DcR3 increases the expression levels of several components of the PI3K/AKT/GSK-3β/β-catenin signaling pathway, such as p-AKT, GSK-3β, p-GSK-3β and β-catenin. Additionally, DcR3 also enhances the expression of N-cadherin and Vimentin and decreases the expression of E-cadherin. Conclusion: In summary, the findings of this study indicate that during GC progression, DcR3 plays a key role in cell proliferation and invasion via the PI3K/AKT/GSK-3β/β-catenin signal

Published
2018

344. Clinicopathological and prognostic significance of FoxM1 in hepatocellular carcinoma patients: a meta-analysis

Author

Liang,Chaojie, Zhao,Jingyang, Ge,Hua, Li,Guangming, Wu,Jixiang, Liang,Chaojie, Zhao,Jingyang, Ge,Hua, Li,Guangming, and Wu,Jixiang

Abstract

Chaojie Liang,1,* Jingyang Zhao,2,* Hua Ge,1 Guangming Li,1 Jixiang Wu1 1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China; 2Department of Tumor Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China *These authors contributed equally to this work Background and aims: Recently, the abnormal expression of FoxM1 has been found in many malignant tumors. However, the clinicopathological and prognostic value of FoxM1 expression in hepatocellular carcinoma (HCC) patients remains controversial. We conducted a meta-analysis to establish the relationship between FoxM1 expression and the clinicopathological features and prognostic value in patients with HCC. Methods: An electronic search for relevant articles was conducted according to a set of criteria in the PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI and Chinese WanFang databases. The correlation data between FoxM1 expression and clinicopathological features and survival outcomes were analyzed. Pooled odds ratios (ORs) and hazard ratios (HRs) with 95% CIs were calculated using STATA14.2. Results: A total of 14 studies comprising of 2,036 patients were enrolled in this meta-analysis. The results showed that FoxM1 expression was related to the incidence, tumor size (>5 cm), vascular invasion, differentiation and TNM stage. Moreover, overexpression of FoxM1 indicated a poor 3- and 5-year overall survival rate (OS) and recurrence-free survival rate (disease-free survival rate). Conclusion: Our meta-analysis indicated that FoxM1 expression was associated with incidence, tumor size (>5 cm), vascular invasion, differentiation and TNM stage. Accordingly, FoxM1 may be a reliable prognostic biomarker for patients with HCC. However, additional high-quality studies are still needed to further support these findings. Keywords: FoxM1, hepatocellular carcinoma, clinicopathological feature, prognosis, meta-analysis

Published
2018

345. Clinicopathological significance and prognostic role of p-STAT3 in patients with hepatocellular carcinoma

Author

Liang,Chaojie, Xu,Yingchen, Ge,Hua, Li,Guangming, Wu,Jixiang, Liang,Chaojie, Xu,Yingchen, Ge,Hua, Li,Guangming, and Wu,Jixiang

Abstract

Chaojie Liang,* Yingchen Xu,* Hua Ge, Guangming Li, Jixiang Wu Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Background and aim: Constitutive activation of STAT3 through its phosphorylation (p-STAT3) plays a key role in the development and progression of various cancers. However, the relationship between p-STAT3 expression and the clinicopathological features and prognostic value in patients with hepatocellular carcinoma (HCC) remains controversial. We conducted a meta-analysis to evaluate the role of p-STAT3 in HCC. Methods: The PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI, and Chinese Wanfang databases were searched using the appropriate terms to find the relevant studies on p-STAT3 and HCC. The relationship between p-STAT3 expression and clinicopathological characteristics and prognostic value was established. Pool odds ratios (ORs) and hazard ratios (HRs) with 95% CIs were calculated using the STATA 14.2 software. Results: The eight articles included in this meta-analysis comprised 752 patients. Expression of p-STAT3 was associated with incidence, age, liver cirrhosis, tumor size, vascular invasion, and TNM stage of HCC, but it was not related to gender, alpha-fetoprotein (AFP), hepatitis B surface antigen (HBsAg), number of tumors, and tumor differentiation. Additionally, the expression of p-STAT3 was related to a poor 3- and 5-year overall survival rate and disease-free survival rate. Conclusion: Expression of p-STAT3 was associated with the incidence, age, liver cirrhosis, tumor size, vascular invasion, and TNM stage. Thus, p-STAT3 can be a reliable prognostic biomarker for HCC. Further high-quality studies with larger numbers of patients are needed. Keywords: p-STAT3, hepatocellular carcinoma, prognosis, meta-analysis

Published
2018

346. The clinicopathological and prognostic value of HSP27 in hepatocellular carcinoma: a systematic review and meta-analysis

Author

Liang,Chaojie, Xu,Yingchen, Ge,Hua, Li,Guangming, Wu,Jixiang, Liang,Chaojie, Xu,Yingchen, Ge,Hua, Li,Guangming, and Wu,Jixiang

Abstract

Chaojie Liang,* Yingchen Xu,* Hua Ge, Guangming Li, Jixiang Wu Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China *These authors contributed equally to this work Background: In the recent past, there is increasing evidence demonstrating that HSP27 plays a key role in tumor progression. However, the relationship between HSP27 expression and the clinicopathological features of hepatocellular carcinoma (HCC), as well as its prognostic value in HCC patients remain controversial. Accordingly, we conducted a meta-analysis to assess the correlation between HSP27 expression and HCC, and determine the prognostic value of HSP27 in HCC.Methods: The data included clinicopathological features and survival information extracted from the published literature in the databases PubMed, EMBASE, Cochrane Library, Web of Science, CNKI, and Wan Fang. The pooled odds ratios and hazard ratios with 95% CIs were calculated using Forest plot analysis.Results: The meta-analysis results indicated that the positive HSP27 expression was significantly correlated with HCC incidence, tumor differentiation, and α-fetoprotein level in patients with HCC. However, the expression of HSP27 was not associated with metastasis, hepatitis B virus surface antigen, gender, tumor size, TNM stage, and vascular invasion. Additionally, HSP27 expression indicated a poor overall survival rate, but it was not related to disease-free survival rate.Conclusion: This meta-analysis revealed that HSP27 may play a key role in the development of HCC and could be a reliable biomarker for the prognosis of patients with HCC. However, additional high-quality research is needed to support the results. Keywords: HCC, heat shock protein 27, meta-analysis&nbsp

Published
2018

347. Role of Beclin1 expression in patients with hepatocellular carcinoma: a meta-analysis

Author

Liang,Chaojie, Li,Wei, Ge,Hua, Zhang,Kaitong, Li,Guangming, Wu,Jixiang, Liang,Chaojie, Li,Wei, Ge,Hua, Zhang,Kaitong, Li,Guangming, and Wu,Jixiang

Abstract

Chaojie Liang,1,* Wei Li,1,* Hua Ge,1 Kaitong Zhang,2 Guangming Li,1 Jixiang Wu1 1Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Tumor Center, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Background and aim: Beclin1 has been reported as a vital marker for a number of malignant tumors. However, the role of Beclin1 in hepatocellular carcinoma (HCC) remains inconclusive. Thus, we conducted a meta-analysis to assess the correlation between Beclin1 and its clinicopathological and prognostic values in HCC.Methods: PubMed, Cochrane Library, Web of Science, EMBASE, Chinese CNKI, and Chinese WanFang databases were searched for published articles on Beclin1 expression in hepatocellular tissues. Standard-compliant articles were screened using the Newcastle–Ottawa Scale for strict quality control of the literature. The correlation of Beclin1 expression with the clinicopathological features and survival outcomes was analyzed. Pooled odds ratios and hazard ratios with 95% confidence intervals were calculated using STATA14.2.Results: Eleven articles with 1,279 patients were included in this meta-analysis. Positive Beclin1 expression was found to be correlated with alpha fetoprotein, liver cirrhosis, and vascular invasion, but not with gender, age, HBsAg, size of tumor, number of tumors, differentiation, and TNM stage. Positive Beclin1 expression was also associated with favorable 5-year overall survival and disease-free survival rates.Conclusion: Our meta-analysis indicated that positive Beclin1 expression was negatively related to alpha fetoprotein, liver cirrhosis, and vascular invasion in HCC. Beclin1 could be used as a prognostic biomarker for HCC. Keywords: Beclin1, hepatocellular carcinoma, prognosis, meta-analysis

Published
2018

348. Analysis of sediment deposition in Lushui Reservoir to guide dredging.

Author

Ge, Hua, Zhu, Lingling, Lin, Qiusheng, and Deng, Chunyan

Abstract

In recent years, sedimentation dredging has received extensive attention as an effective way to extend the life of reservoirs and to address the global shortage of sediment resources. Thus, sediment deposition analysis can inform reservoir sedimentation dredging. Based on a series of field data for 10 fixed sections observed over 6 years and two topographic observations in the Lushui Reservoir, Hubei Province in China since 1959, the characteristics of sediment deposition, including the amount, the longitudinal distribution, and the transverse distribution in different periods, were analyzed in this study. The results show that sedimentation mainly occurred within 15 km of the dam with an equal thickness along the wetted perimeter during the flood detention period. After the impoundment of the reservoir, sedimentation mainly occurred in the central 7 km section of the reservoir, which is about 15 km away from the dam. In addition, the main deposition is on the primary channel with a small amount on the beaches. In general, the sediment deposition of the Lushui Reservoir is not significant, accounting for only 4% of the total reservoir capacity. However, the siltation in the local reservoir sections is more prominent. Some measurements should be taken to control the sediment deposition to maintain the effective storage capacity of the reservoir, and four dredging zones were proposed based on the analysis. [ABSTRACT FROM AUTHOR]

Published
2021
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349. Clinicopathological and prognostic significance of OCT4 in patients with hepatocellular carcinoma: a meta-analysis

Author

Liang,Chaojie, Xu,Yingchen, Ge,Hua, Li,Guangming, and Wu,Jixiang

Subjects
digestive system diseases, OncoTargets and Therapy
Abstract

Chaojie Liang,* Yingchen Xu,* Hua Ge, Guangming Li, Jixiang Wu Department of General Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China *These authors contributed equally to this work Background and aims: Octamer-binding transcription factor 4 (OCT4) has been implicated in the development of hepatocellular carcinoma (HCC), although the findings are controversial. We conducted a meta-analysis to assess the correlation between OCT4 and the clinicopathological characteristics and the prognostic value in HCC.Methods: An electronic search for relevant articles was conducted in PubMed, Cochrane Library, Web of Science, EMBASE database, Chinese CNKI, and Chinese WanFang database. Correlations between OCT4 expression and clinicopathological features and survival outcomes were analyzed. Pooled odds ratios and hazard ratios with 95% CIs were calculated using STATA 14.2 software.Results: A total of 10 trials with 985 patients were included. Positive OCT4 expression was correlated with tumor size, tumor numbers, differentiation, and TNM stage. OCT4 expression was not correlated with gender, age, hepatitis B surface antigen, alfa-fetoprotein, liver cirrhosis, vascular invasion, or tumor encapsulation. OCT4 expression was associated with poor 3- and 5-year overall survival, and disease-free survival rate.Conclusion: OCT4 expression was associated with tumor size, tumor numbers, differentiation, and TNM stage in HCC. OCT4 may be a useful prognostic biomarker for HCC. Keywords: octamer-binding transcription factor 4, hepatocellular carcinoma, prognosis, meta-analysis

Published
2017

350. Application of Infrared Dual Light Color Temperature Measurement System in AOD Furnace and Converter

Author

Chen Ge-hua and Yang Xiantao

Subjects
Materials science, Optics, Thermocouple, Infrared, business.industry, System of measurement, Nozzle, Color temperature, business, Temperature measurement, Compensation (engineering), Tuyere
Abstract

At present, the converter and AOD furnace temperature often use platinum and rhodium thermocouple, the method can only be a single point temperature and high cost. In order to solve this problem, an on-line infrared dual-light colorimetric non-contact temperature measurement system was developed.The temperature measuring system was used to reconstruct the original sub-gun, and the temperature of the nozzle was realized without affecting the original function. According to the theory of tuyere gray body, the function conversion of the body cavity in the nozzle is analyzed, and the mathematical model of temperature compensation is established, which realizes the compensation of the temperature at the nozzle. The temperature measurement system has been applied to the production practice, with online continuous temperature measurement, high precision, long life and other advantages, improve the end hit rate.

Published
2017
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