190 results on '"Filice, L"'
Search Results
152. Simulation of aluminum foam behavior in compression tests
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Filice, L., Gagliardi, F., and DOMENICO UMBRELLO
153. A simple model for predicting the thermal flow on the tool in orthogonal cutting process
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Filice, L., Umbrello, D., Micari, F., Luca Settineri, L FILICE, D UMBRELLO, MICARI F, and L SETTINERI
154. Simulazione numerica: previsione usura nei processi di taglio
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Filice, L., Rizzuti, S., Umbrello, D., Pulice, F., and Luca Settineri
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SIMULAZIONE FEM ,TAGLIO ,USURA
155. Burnishing of AM materials to obtain high performance part surfaces
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Michela Sanguedolce, Giovanna Rotella, Maria Rosaria Saffioti, Luigino Filice, Sanguedolce, M., Rotella, G., Saffioti, M. R., and Filice, L.
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Superfícies -- Tractament ,HF5001-6182 ,Industrial engineering. Management engineering ,Strategy and Management ,Commerce ,Economia i organització d'empreses::Direcció d'operacions [Àrees temàtiques de la UPC] ,Surface preparation ,Social Sciences ,T55.4-60.8 ,simulation ,sustainability ,Industrial and Manufacturing Engineering ,smart manufacturing, burnishing, additive manufacturing, simulation, sustainability ,HF1-6182 ,Sustainable development ,ddc:650 ,Desenvolupament sostenible ,burnishing ,Business ,smart manufacturing ,Manufacturing processes ,additive manufacturing ,Fabricació - Abstract
Purpose: This paper aims to provide a flexible solution to include additive manufacturing into a process chain complying with Industry 4.0 pillars, overcoming major drawbacks in terms of reliability and experimental effort. Design/methodology/approach: The study is based on the combination of real experimental activities and simulated ones. Findings: The main findings of this work consist into validation of the proposed process chain, which proves to be effective in terms of process flexibility (additive manufacturing, burnishing and process simulation acting synergistically), cost and time reduction and final output quality, encouraging customer involvement towards customization. Originality/value: This paper contributes to current research on the application of burnishing process, an easy to implement and environmentally friendly post-processing method to improve the performance of AM products, by providing a unique perspective integrating a reliable simulation model. Other researchers can employ these outcomes towards manufacturing of the future. A reduced version of this work has been previously published in Procedia Computer Science (Sanguedolce, Rotella, Saffioti & Filice, 2021)
- Published
- 2022
156. Aerosol Jet® Printing on stereolithography resin substrates for in-vitro dual bioreactor sensing
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Miriam Seiti, Paola Serena Ginestra, Akash Verma, Elisabetta Ceretti, Eleonora Ferraris, Ceretti, E, and Filice, L
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General Earth and Planetary Sciences ,General Environmental Science - Abstract
Aerosol Jet® Printing (AJ®P) is a relatively novel additive manufacturing technique, of the type direct writing, principally applied for printed electronics. Particularly, AJ®P has the ability to print various functional inks (conductive, dielectrics, biological solutions) at micro-scale resolution and on free-from substrates. This work investigates AJ®P to fabricate conductive patterns on stereolithography (SLA) samples towards the development of an innovative bioelectrical device for in-vitro dual bioreactor sensing. Silver nanoparticle (AgNPs) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) inks were both tested. Preliminary results show a low metal-polymer AgNPs-SLA interaction, revealing the presence of pores and cracks along with the printed pattern after thermal sintering, with no electrical resistance (R) detected. In contrast, the PEDOT:PSS ink reveals a good covering of the SLA samples, with R decreasing with the number of printed layers (from ~700 KΩ to ~60 Ω for 15 and 40 layers, respectively, on lines 1 cm long). However, using the PEDOT:PSS ink, the total printing time was ~45 minutes, hence not ideal for an industry-oriented vision. Therefore, a study on the optimization of the AgNPs-SLA sample interaction was carried out. SLA samples were coated with Parylene-C (ParC), and further treated with a low pressure plasma. The final results show excellent conductivity (R~2.40 Ω), with a printing time of ~5.5 minutes (7 layers), demonstrating the possibility to obtain a functional circuit. Eventually, the circuit was encapsulated with polydimethylsiloxane (PDMS) in order to avoid a release of Ag+ ions, potentially toxic in the medium culture. ispartof: pages:174-179 ispartof: Procedia CIRP vol:110 pages:174-179 ispartof: V Cirp Biomanufacturing location:Calabria, Italy date:22 Jun - 24 Jun 2022 status: Published online
- Published
- 2022
157. Implementation of an Automated Manufacturing Platform for Engineering of Functional Osteochondral Implants
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Krieger, Judith, Nießing, Bastian, König, Niels, Mota, Carlos, La Pointe, Vanessa, Van Rijt, Sabine, Kondro, Douglas, Hiatt, Michael, Viellerobe, Bertrand, Brisson, Bruno, Marechal, Marina, Geris, Liesbet, Luyten, Frank P., Papantoniou, Ioannis, Schmitt, Robert H., CTR, RS: MERLN - Complex Tissue Regeneration (CTR), Division Instructive Biomaterials Eng, RS: MERLN - Instructive Biomaterials Engineering (IBE), Ceretti, E, Filice, L, and Publica
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Technology ,Materials Science, Biomaterials ,Science & Technology ,Tissue Engineering ,Stem Cells ,Materials Science ,Bioprinting ,Regenerative Medicine ,Engineering, Manufacturing ,Automation ,Engineering ,Osteoarthritis ,General Earth and Planetary Sciences ,ddc:600 ,Engineering, Biomedical ,General Environmental Science - Abstract
5. CIRP Conference on BioManufacturing, CirpBioM 2022, Maierato, Italy, 22 Jun 2022 - 24 Jun 2022; Procedia CIRP 110, 32-35 (2022). doi:10.1016/j.procir.2022.06.008 special issue: "V CIRP Conference on BioManufacturing / edited by Elisabetta Ceretti, Luigino Filice", Published by Elsevier, Amsterdam [u.a.]
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- 2022
158. Biocompatibility evaluation of encapsulated silver-based printed circuits for in-vitro long-term sensing devices
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Rosalba Monica Ferraro, Miriam Seiti, Paola Serena Ginestra, Elena Laura Mazzoldi, Eleonora Ferraris, Elisabetta Ceretti, Silvia Giliani, Ceretti, E, and Filice, L
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Engineering, Manufacturing ,Silver nanoparticle inks ,Technology ,Materials Science, Biomaterials ,Bioelectronics ,Science & Technology ,Engineering ,biocompatibility ,Materials Science ,Printing of electronics ,General Earth and Planetary Sciences ,Engineering, Biomedical ,General Environmental Science - Abstract
ispartof: pages:99-104 ispartof: V CIRP CONFERENCE ON BIOMANUFACTURING vol:110 pages:99-104 ispartof: 5th CIRP Conference on BioManufacturing (BioM) location:ITALY, Calabria date:22 Jun - 24 Jun 2022 status: published
- Published
- 2022
159. Surface Modifications Induced by Roller Burnishing of Ti6Al4V Under Different Cooling/Lubrication Conditions
- Author
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Giovanna Rotella, Luigino Filice, Rotella, G., and Filice, L.
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Wear resistance ,Materials science ,Design of experiments ,Titanium alloy ,Tribology ,Roller burnishing ,Burnishing ,Burnishing (metal) ,Surface integrity ,Severe plastic deformation ,Lubrication ,Surface roughness ,Composite material - Abstract
The paper presents a deep analysis of surface modifications induced by roller burnishing process of Ti6Al4V titanium alloy. The extensive experimental campaign has been performed based on a Design of Experiments at varying lubrication/cooling strategies (dry, cryogenic and MQL), roller radius, burnishing speed and burnishing depth. The resulting surface integrity has been analyzed in terms of surface roughness, micro hard-ness, microstructural changes and tribological performance. In particular, the wear rate of the burnished sample has been evaluated as a quality indicator of the process. The overall results show the influence of burnishing process parameters on surface quality and wear resistance of Ti6Al4V highlighting the capability of the process to significantly improve the above performance especially when cryogenic cooling is applied. Finally, the extensive experimental activity allowed to find a combination of processing parameters and lubrication conditions able to significantly improve the surface quality of the final component.
- Published
- 2021
160. Prediction of Surface Integrity Parameters in Roller Burnishing of Ti6Al4V
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Luigino Filice, Antonio Del Prete, Giovanna Rotella, Serafino Caruso, Rotella, G., Caruso, S., Del Prete, A., and Filice, L.
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lcsh:TN1-997 ,0209 industrial biotechnology ,Work (thermodynamics) ,roller burnishing ,Computer science ,Roller burnishing ,Metals and Alloys ,Process (computing) ,Mechanical engineering ,Titanium alloy ,02 engineering and technology ,Surface finish ,surface integrity ,021001 nanoscience & nanotechnology ,Burnishing (metal) ,Surface integrity ,020901 industrial engineering & automation ,statistics ,General Materials Science ,Statistical analysis ,0210 nano-technology ,lcsh:Mining engineering. Metallurgy ,Statistic - Abstract
Burnishing is considered a super finishing process able to drastically increase surface quality in terms of hardness and roughness of the manufactured parts. Consequently, it is considered appealing for the performance enhancement of products where the surface quality plays a crucial role. However, when burnishing grade 5 titanium alloy, a quantitative relationship between process parameters and surface integrity is still missing. This work provides a deep analysis of the burnishing parameters and their influence on the surface integrity of Ti-6Al-4V. In particular, starting from a large experimental campaign, statistical analysis of the results is performed and models able to describe the surface integrity response based on different burnishing parameters are presented. The overall results allow us to clearly define the relationship within the input and output variables identifying, by the proposed models, different operational windows for surface integrity improvement.
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- 2020
161. Machinability of Waspaloy under different cutting and lubri-cooling conditions
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A. Del Prete, Luigino Filice, Rodolfo Franchi, Serafino Caruso, Sergio Rinaldi, Domenico Umbrello, Rinaldi, S., Caruso, S., Umbrello, D., Filice, L., Franchi, R., and Del Prete, A.
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0209 industrial biotechnology ,Machinability ,Materials science ,Context (language use) ,02 engineering and technology ,Waspaloy ,Industrial and Manufacturing Engineering ,Specific strength ,020901 industrial engineering & automation ,0203 mechanical engineering ,Machining ,medicine ,Tool wear ,Mechanical Engineering ,Metallurgy ,Stiffness ,Computer Science Applications ,Superalloy ,020303 mechanical engineering & transports ,Control and Systems Engineering ,Cutting ,medicine.symptom ,Lubri-cooling condition ,Software - Abstract
Nickel-based super alloys are widely employed in critical applications, mainly in aerospace, marine, and chemical industries, concerning the production of high-performance artifacts. These alloys are considered as hard-to-cut materials, because of their modest machinability, so it is very difficult to implement in an industrial context high-speed machining processes that can lead to higher quality products, with improved mechanical characteristics and higher dimensional accuracy, and increase productivity. Among these alloys stands out Waspaloy, thanks to its very high mechanical properties, such as stiffness and strength to weight ratio. In order to implement effective machining processes, it is important to analyze the behavior of the material during machining in terms of variables of industrial interest (forces, tool wear, etc.). The aim of this paper is to disclose the results of an experimental investigation aimed to determine the effects of different cutting parameters on cutting forces, chip morphology, tool wear, and temperature at tool-chip interface, during orthogonal machining of Waspaloy (45 HRC). Experiments were performed in different lubri-cooling conditions (dry, wet, and cryogenic) and at varying cutting conditions (cutting speed and feed rate).
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- 2018
162. Numerical Simulation of Machining Nickel-Based Alloys
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Domenico Umbrello, Luigino Filice, Antonio Del Prete, Del Prete, A., Filice, L., Umbrello, D., and DEL PRETE, Antonio
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FEM ,Materials science ,Viscoplasticity ,Inconel 718 ,Chip formation ,Metallurgy ,Constitutive equation ,Mechanical engineering ,Flow stress ,Machining ,Material flow ,Stress (mechanics) ,General Earth and Planetary Sciences ,Material characterization ,Inconel ,General Environmental Science - Abstract
The phenomenological models for material flow stress and fracture, typically used in the Finite Element simulations of machining Nickel-based alloys, are often deemed to represent only certain metallurgical material states. In contrast, these models are not suitable to describe the constitutive behavior of the workpiece for different metallurgical states (i.e., annealed, aged, etc.) and, consequently, different hardness values. Since the description of the material behavior requires correct formulation of the constitutive law, new flow stress models which include also the hardness effect should be developed and used, for computer simulation of machining Nickel-based alloys. This paper describes the development of a hardness-based flow stress and fracture models for machining Inconel 718 alloy which can be applied for a wide range of work material hardness. These models have been implemented in a non-isothermal viscoplastic numerical model to simulate the influence of work material hardness on the chip formation process. The predicted results are being validated with experimental results properly carried out for this research. They are found to satisfactory predict the cutting forces, the temperature and the chip morphology from continuous to segmented chip as the hardness values change. Copyright © 2013 Elsevier B.V.
- Published
- 2013
163. A preliminary comparison between finite element and meshless simulations of extrusion
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Luigino Filice, Fabrizio Micari, Elías Cueto, Icíar Alfaro, F. Gagliardi, Francisco Chinesta, Alfaro, I, Chinesta, F, Cueto, E, Filice, L, Gagliardi, F, and Micari, F
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Regularized meshless method ,Materials science ,Finite element limit analysis ,business.industry ,Metals and Alloys ,Mixed finite element method ,Structural engineering ,Boundary knot method ,Industrial and Manufacturing Engineering ,Finite element method ,Discrete element method ,Computer Science Applications ,extrusion modelling ,Modeling and Simulation ,Ceramics and Composites ,Smoothed finite element method ,meshless method ,business ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,Extended finite element method - Abstract
In this paper the extrusion process of a cross-shaped profile was investigated. In particular, the study was focused on the distortion of extruding profiles when the workpiece and die axis are not aligned. The process was simulated using the finite element method (FEM) and the natural element method (NEM), both implemented in an updated-Lagrangian formulation, in order to avoid the burden associated with the description of free surfaces in ALE or Eulerian formulations. Furthermore, an experimental equipment was developed in order to obtain reliable data in terms of deformed entity, required process load and calculated pressure. At the end, a comparison between the numerical predictions and the experimentally measured data was carried out. The main results are presented in the paper.
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- 2009
164. Assessment of material models through simple machining tests
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Luigino Filice, S. Rizzuti, Fabrizio Micari, Francisco Chinesta, Domenico Umbrello, Laboratoire de Mécanique des Systèmes et des Procédés (LMSP), Centre National de la Recherche Scientifique (CNRS), Università della Calabria [Arcavacata di Rende] (Unical), Università degli studi di Palermo - University of Palermo, Chinesta, F, Filice, L, Rizzuti, S, Umbrello, D, and Micari, F.
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0209 industrial biotechnology ,Engineering ,Interface (computing) ,Mechanical engineering ,Computational intelligence ,02 engineering and technology ,material models ,Flow stress ,Finite Element Simulation ,[SPI]Engineering Sciences [physics] ,020901 industrial engineering & automation ,0203 mechanical engineering ,Machining ,modelling of machining ,General Materials Science ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,Material modelling ,Inverse Approach ,Coupling ,business.industry ,Process (computing) ,Finite element method ,Identification (information) ,020303 mechanical engineering & transports ,business - Abstract
The accuracy of the results obtained from FEM simulation of machining operations depends on the accuracy of input data. Among these, the flow stress data of the workpiece are extremely important together with the friction along the tool-chip interface. In this study, an identification procedure for the determination of material parameters that are used for the FEM simulation of machining processes is proposed. The procedure is based on the coupling of a numerical identification procedure and Arbitrarian Lagrangian Eulerian (ALE) Finite Element simulations of turning operations. An experimental campaign was developed in order to calibrate the model and to validate the procedure. The basic idea is to utilize only machining tests to properly define the material behaviour of the workpiece material, taking also into account the thermal phenomena involved in the process. The preliminary results of this analysis are discussed in the paper.
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- 2008
165. Prediction of Tool Wear Progress in Machining of Carbon Steel using different Tool Wear Mechanismsl
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Takahiro Shirakashi, Fabrizio Micari, Luigino Filice, Takashi Matsumura, Domenico Umbrello, Umbrello, D, Filice, L, Matsumura, T, Shirakashi, T, and Micari, F.
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Materials science ,Carbon steel ,Metallurgy ,Mechanical engineering ,engineering.material ,Finite element method ,tool wear ,Abrasion (geology) ,Carbide ,Machining ,Calibration ,engineering ,General Materials Science ,Tool wear ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,mechanisms and prediction - Abstract
In this paper the prediction of tool wear on carbide uncoated tools was taken into account. In particular, two different tool wear models based on the diffusion mechanism and on the abrasion mechanism were considered. The calibration of the utilized models was done using the results obtained by experimental analysis performed on an orthogonally machined AISI 1020 tube. Once the calibration was executed, numerical simulations, for both the utilized tool wear models, were simultaneously performed with the aim to test the capability of the proposed numerical procedure. The comparison between the two tool wear mechanisms for predicting the flank tool wear is discussed in the paper.
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- 2008
166. An analytical model for improving precision in single point incremental forming
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Luigino Filice, Fabrizio Micari, G. Ambrogio, Valentina Cozza, AMBROGIO G, COZZA V, FILICE L, and MICARI F
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Engineering ,Engineering drawing ,business.product_category ,business.industry ,media_common.quotation_subject ,Frame (networking) ,Metals and Alloys ,Process (computing) ,Mechanical engineering ,Industrial and Manufacturing Engineering ,Computer Science Applications ,Simple (abstract algebra) ,Modeling and Simulation ,visual_art ,Ceramics and Composites ,visual_art.visual_art_medium ,Die (manufacturing) ,Production (economics) ,Simplicity ,business ,Sheet metal ,Incremental sheet forming ,media_common - Abstract
In the modern manufacturing scenario and, in particular, in sheet metal forming, the requirement of customised production is still growing. The introduction of incremental forming enables the production of customised components in small lots. In particular, single point incremental forming is characterised by the simplest equipment; any die, in fact, is avoided reducing the necessary tooling to a simple frame, able to clamp the sheet, and a hemispherical punch that imposes the required deformation. This tooling simplicity and the associated process mechanics, in turn, determine a sometimes relevant lack of accuracy. The paper is focused on the investigation of the influence of the process parameters on accuracy through a reliable statistical analysis. The obtained models permit to implement some effective actions to improve the accuracy taking into account a simple case study.
- Published
- 2007
167. On the effectiveness of Finite Element simulation of orthogonal cutting with particular reference to temperature prediction
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Luigino Filice, Luca Settineri, Stefania Rizzuti, Fabrizio Micari, Domenico Umbrello, UMBRELLO D, FILICE L, RIZZUTI S, MICARI F, and SETTINERI L
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FEM ,Engineering ,Computational complexity theory ,Computer simulation ,business.industry ,Interface (computing) ,Flow (psychology) ,Metals and Alloys ,FRICTION ,Mechanical engineering ,Heat transfer coefficient ,Chip ,Industrial and Manufacturing Engineering ,Computer Science Applications ,cutting temperature ,machining ,TOOL WEAR ,Modeling and Simulation ,Thermal ,Ceramics and Composites ,FLOW-STRESS ,Tool wear ,business ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione - Abstract
Finite Element simulation of orthogonal cutting is nowadays assuming a large relevance; in fact a very large number of papers may be found out in technical literature on this topic. In recent years, numerical simulation was performed to investigate various phenomena such as chip segmentation, force prediction and tool wear. On the other hand, some drawbacks have to be highlighted; due to the geometrical and computational complexity of the updated-Lagrangian formulation mostly used in FE codes, a cutting time of only a few milliseconds can be effectively simulated. Therefore, steady-state thermal conditions are not reached and the simulation of the thermal phenomenon may be ineffective. In order to overcome such problem two different approaches are proposed in this paper. The former is based on a pure thermal simulation once the thermal flow on the tool is properly calculated. The latter, on the contrary, is based on an artificial modification of the heat transfer coefficient at the interface between the chip and the tool in the thermo-mechanical simulation. Both of the proposed methodologies are discussed in the paper, highlighting the advantages and the drawbacks of each of them.
- Published
- 2007
168. Wear modelling in mild steel orthogonal cutting when using uncoated carbide tools
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Fabrizio Micari, Domenico Umbrello, Luca Settineri, Luigino Filice, FILICE L, MICARI F, SETTINERI L, and UMBRELLO D
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FEM ,Materials science ,Cutting tool ,Chip formation ,Reference data (financial markets) ,Mechanical engineering ,Surfaces and Interfaces ,tool wear prediction, carbide tools, temperature in cutting, FEM ,Condensed Matter Physics ,Chip ,Finite element method ,Surfaces, Coatings and Films ,Tool wear prediction ,Carbide tools ,Temperature in cutting ,Machining ,Mechanics of Materials ,Materials Chemistry ,Tool wear ,Reference model - Abstract
Wear prediction in machining has been recently studied by FEM although the use of numerical methods for such applications is still a very challenging research issue. In fact, wear phenomenon involves many aspects related to process mechanics which require a very accurate modelling. In other words, only a very punctual code set-up can help the researchers in order to obtain consistent results in FE analysis. The high relative velocity between chip and tool requires effective material models as well as friction modelling at the interface. Moreover the prediction of temperature distribution is another critical task; in the paper some different procedures are discussed. Subsequently a wear model is presented and calibrated in order to obtain a suitable tool to be implemented in a FE code with the aim to describe the wear evolution during the simulation process. A proper designed experimental campaign supplied some reference data for model set-up and verify in the practical application. All these aspects are carefully discussed in the paper.
- Published
- 2007
169. ALE Simulation of Orthogonal Cutting: a New Approach to Model Heat Transfer Phenomena at the Tool-Chip Interface
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Fabrizio Micari, Luigino Filice, Domenico Umbrello, Elisabetta Ceretti, CERETTI E, FILICE L, UMBRELLO D, and MICARI F
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Engineering ,Basis (linear algebra) ,business.industry ,Mechanical Engineering ,Interface (computing) ,finite element method ,Process (computing) ,Mechanical engineering ,Interval (mathematics) ,Heat transfer coefficient ,Chip ,Industrial and Manufacturing Engineering ,heat transfer coefficient ,Heat transfer ,Tool wear ,business ,cutting ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione - Abstract
This paper presents a new procedure to evaluate the global heat transfer coefficient in orthogonal cutting. The knowledge of the actual heat transfer conditions is a fundamental issue as far as the life, tool wear and tool substitution interval are regarded. More in detail, an Arbitrary Lagrangian-Eulerian approach was utilised to model orthogonal cutting process and the numerical simulations were validated by making experimental tests for identifying cutting forces and internal tool temperatures. A mild steel was cut utilising both an uncoated (WC) and a coated (TiN) tool. On the basis of both experimental and simulative data, a consistent model of the global heat transfer coefficient as function of the local pressure and temperature at the tool-workpiece interface was developed.
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- 2007
170. On-Line Control of Single Point Incremental Forming Operations through Punch Force Monitoring
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G. Ambrogio, Fabrizio Micari, Luigino Filice, FILICE L, AMBROGIO G, and MICARI F
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Engineering drawing ,Engineering ,business.industry ,Mechanical Engineering ,Process (computing) ,Mechanical engineering ,Forming processes ,CAD ,computer.software_genre ,Industrial and Manufacturing Engineering ,Machining ,visual_art ,Computer-aided manufacturing ,visual_art.visual_art_medium ,Computer Aided Design ,Material failure theory ,business ,Sheet metal ,computer - Abstract
Among the innovative sheet metal forming processes, Single Point Incremental Forming (SPIF) represents the simplest and the cheapest one. Despite its relevant advantages, up to now no specific CAE tools for SPIF were developed and the tool trajectory is generally defined utilizing CAD/CAM software developed for machining applications. In the paper an innovative monitoring and control approach, aimed to define and in-process update the most relevant process parameters during an industrial SPIF operation, is proposed. The strategy utilizes as monitoring variable the punch force trend: a set of preliminary tests demonstrated, in fact, its suitability as “spy variable” of the process mechanics and, in particular, of excessive sheet thinning and material failure approaching.
- Published
- 2006
171. Friction stir welding of stainless steel thin sheets in lap configuration
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Gianluca Buffa, Fabrizio Micari, Luigi Filice, Livan Fratini, Buffa, G, Fratini, L, Filice, L, and Micari, F
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Materials science ,FSW ,Metallurgy ,Titanium alloy ,lap joints ,Thin sheet ,Strain rate ,Electric resistance welding ,Finite element method ,Lap joint ,Friction stir welding ,Friction welding ,Composite material ,stainless steel ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione - Abstract
New research trends for Friction Stir Welding include the use of highly resistant materials as steels and titanium alloys. In the paper a continuum based FEM model for Friction Stir Welding of lap joint made out of thin stainless steel sheets is proposed, that is 3D Lagrangian implicit, coupled, rigid-viscoplastic. The model, whose potential has been analyzed though temperature distribution comparisons, is able to predict temperature, strain and strain rate distributions, with varying process variables. In this way the FEM model can be applied for effective process and tool design.
- Published
- 2013
172. Tool Engage Investigation in Nickel Superalloy Turning Operations
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Luigino Filice, Antonio Del Prete, Serafino Caruso, Antonio Alberto de Vitis, Domenico Umbrello, DEL PRETE, Antonio, DE VITIS, ANTONIO ALBERTO, Filice, L., Caruso, S., and Umbrello, D.
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Insert (composites) ,Materials science ,Cutting tool ,business.industry ,Mechanical Engineering ,Metallurgy ,Drilling ,Mechanical engineering ,Inconel 718 alloy ,Tool Wear ,Carbide ,Superalloy ,Cutting Force ,Mechanics of Materials ,General Materials Science ,Tool wear ,Aerospace ,business ,Inconel - Abstract
This paper reports the results of an experimental study of the tool wear and cutting forces in turning of Inconel 718 with coated carbide inserts. Inconel 718 is a difficult-to-cut nickel-based super-alloy commonly used in aerospace industry. The effects of cutting speed, feed rate and cutting tool geometry on tool wear have been widely analyzed in literature. Turning operations on complex components such as aircraft engines casings require the insert replacement at the end of each geometric feature manufacturing, independently from the actual tool wear level. For this reason, it is important to preserve tool integrity mainly in the most critical phase of operation (i.e., when the tool engages the workpiece). In fact, if the tool is damaged in this stage the quality of the whole operation is compromised. The attention has been focused on engage cutting conditions because the phenomenon that appears in this critical step plays a wide influence on tool integrity and, consequently, on the quality of the operation. For this purpose a nickel-based super alloy ring-workpiece, (Inconel 718), has been machined in lubricated cutting conditions by using a CNC lathe with carbide coated tools. Two variables have been investigated in this study: the Depth Of Cut (DOC) and the approaching Engage angle (En). In the studied working conditions Speed (S), Feed-rate (F) and removed volume (Vrim) were kept constant. Both tool wear and cutting forces evolution during cutting have been analyzed.
- Published
- 2012
173. On the evaluation of the global heat transfer coefficient in cutting
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S. Rizzuti, Fabrizio Micari, Domenico Umbrello, Luigino Filice, UMBRELLO D, FILICE L, RIZZUTI S, and MICARI F
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Mathematical optimization ,Steady state ,Mechanical Engineering ,Rake ,MODELS ,Mechanics ,Heat transfer coefficient ,Pressure coefficient ,Industrial and Manufacturing Engineering ,Finite element method ,TOOL WEAR ,Machining ,TEMPERATURE DISTRIBUTION ,Heat transfer ,SIMULATION ,Process simulation ,FINITE-ELEMENT-ANALYSIS ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,Mathematics - Abstract
The use of numerical simulations for investigating machining processes is remarkably increasing because of the simulation cost is lower than the experiments and the possibility to analyze local variables such as pressures, strains, and temperatures is allowable. Process simulation is very hard from a computational point of view, since it frequently requires remeshing phases and very small time steps. As a consequence, the simulated cutting time is usually of the order of few milliseconds and no steady cutting conditions are generally achieved, at least as far as thermal conditions are concerned. Therefore, nowadays numerical prediction of cutting temperatures cannot be considered fully reliable. In the paper this issue was taken into account: a mixed Lagrangian-Eulerian numerical approach was utilized and the global heat transfer (film) coefficient at the tool-chip interface was derived through an inverse approach. Finally, the dependence of the film coefficient on pressure and temperature on the rake face was investigated.
- Published
- 2007
174. A Critical Analysis on the Friction Modeling in Orthogonal Cutting of Steel
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Fabrizio Micari, Domenico Umbrello, S. Rizzuti, Luigino Filice, FILICE L, MICARI F, RIZZUTI S, and UMBRELLO D
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Engineering ,Complex field ,Computer simulation ,business.industry ,Robustness (computer science) ,Numerical analysis ,FrictionOrthogonal cuttingTemperature distribution ,Mechanical engineering ,business ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione - Abstract
Numerical simulation of cutting process is today moving towards two different directions. The former concerns the development of high performance codes able to approach the 3D phenomena, the latter is already focused on the study of some fundamental aspects whose full understanding may be strategic for the knowledge enhancing in this very complex field. In the paper this second way was pursued and a wide analysis on the numerical robustness of the 2D orthogonal cutting process is presented. In particular, the role played by the friction modeling is discussed taking into account a wide integrated numerical and experimental campaign.
- Published
- 2007
175. A critical analysis on the friction modelling in orthogonal machining
- Author
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S. Rizzuti, Fabrizio Micari, Domenico Umbrello, Luigino Filice, FILICE, L, MICARI, F, RIZZUTI, S, and UMBRELLO, D
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Task (computing) ,Engineering ,Machining ,orthogonal cutting, friction, temperature distribution ,business.industry ,Mechanical Engineering ,Mechanical engineering ,Experimental work ,business ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,Industrial and Manufacturing Engineering ,Finite element method ,Simulation - Abstract
Despite the development of high performance finite element-based codes, the simulation of machining still represents a very hard task due to the geometric complexity of the real chip-tool systems and the high cutting speed that requires very long simulation times. For these reasons, many aspects related to machining are not very clear and so easy to simulate. In this paper a rigorous investigation on the role played by the implemented friction model within a 2D simulation of orthogonal cutting was carried out, taking into account different models proposed by the researchers in the last years. The main simulation results were compared with experimental measurements in order to verify if it is possible to identify the best model. Once the comparison with mechanical variables was completed, a subsequent study on temperature predictions utilizing the above friction models was executed as well. The results of this integrated numerical and experimental work are carefully reported in the paper.
- Published
- 2007
176. A depth dependent analytical approach to determine material breaking in SPIF
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G. Ambrogio, Luigino Filice, L Manco, Fabrizio Micari, AMBROGIO G, FILICE L, MANCO L, and MICARI F
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Materials science ,business.product_category ,ANOVA ,business.industry ,Depth dependent ,Process (computing) ,Forming processes ,Structural engineering ,Mechanics ,Fracture (geology) ,Die (manufacturing) ,Formability ,Point (geometry) ,incremental forming ,Single point ,material formability ,business ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione - Abstract
Formability is a relevant issue in Single Point Incremental Forming (SPIF) process since it is one of the main point of strength together to the possibility to avoid any dedicated die. Several researches agree that, depending on working material and process parameters, in SPIF operations there is a threshold slope of the wall that cannot be overcame without material breaking. If deep Incremental Forming is taken into account, despite the previous statement it is possible to demonstrate that, when the threshold angle is imposed, there is a relation between the actual workpiece depth and the material breaking approaching. In this paper, the latter relationship was investigated and formally derived by using a proper statistical regression.
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- 2007
177. A force measuring based strategy for failure prevention in incremental forming
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Fabrizio Micari, G. Ambrogio, Luigino Filice, AMBROGIO G, FILICE L, and MICARI F
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Engineering ,Process (engineering) ,business.industry ,Metals and Alloys ,sheet metal forming ,Failure prevention ,Forming processes ,Industrial and Manufacturing Engineering ,Manufacturing engineering ,Field (computer science) ,Computer Science Applications ,Reliability engineering ,Modeling and Simulation ,Ceramics and Composites ,Formability ,Lack of knowledge ,Material failure theory ,incremental forming ,Slowness ,business ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,force monitoring - Abstract
Incremental forming processes show a number of advantages compared to the traditional processes but, at the same time, some drawbacks are clearly known. Current problems, include the slowness of the process, low accuracy and a lack of knowledge in the field of material formability. This paper is focused on the latter issue: an industrially oriented methodology for detecting the approach of failure in incremental forming is proposed. The approach is based on the analysis of the trend of the forming force in order to assess whether the process can be run safely. If not, a proper strategy, to avoid material failure, is proposed and experimentally validated.
- Published
- 2006
178. Cross Extrusion With Asymmetric Die: A Comparison Between Finite Element and Meshless Formulation Predictions
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de Souza Castro Filice, Letícia, Alfaro, Icíar, Gagliardi, Francesco, Cueto, Elías, Micari, Fabrizio, Chinesta, Francisco, Aragón Institute of Engineering Research [Zaragoza] (I3A), University of Zaragoza - Universidad de Zaragoza [Zaragoza], Università della Calabria [Arcavacata di Rende] (Unical), Università degli studi di Palermo - University of Palermo, Laboratoire de Mécanique des Systèmes et des Procédés (LMSP), Université d'Orléans (UO)-Centre National de la Recherche Scientifique (CNRS), Zidekhile, Farida, FILICE L, ALFARO I, GAGLIARDI F, CUETO E, MICARI F, and CHINESTA F
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[SPI.MECA]Engineering Sciences [physics]/Mechanics [physics.med-ph] ,[SPI.MECA] Engineering Sciences [physics]/Mechanics [physics.med-ph] - Published
- 2006
179. Influence of mechanical properties of the sheet material on formability in single point incremental forming
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Livan Fratini, Luigino Filice, G. Ambrogio, Fabrizio Micari, R. Di Lorenzo, FRATINI L, AMBROGIO G, DI LORENZO R, FILICE L, and MICARI F
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Flexibility (anatomy) ,Materials science ,Mechanical Engineering ,Metallurgy ,Forming processes ,Blank ,Industrial and Manufacturing Engineering ,medicine.anatomical_structure ,single point incremental forming ,visual_art ,Fracture (geology) ,medicine ,visual_art.visual_art_medium ,Formability ,Statistical analysis ,Single point ,Composite material ,Sheet metal - Abstract
New trends in sheet metal forming are rapidly developing and several new forming processes have been proposed to accomplish the goals of flexibility and cost reduction. Among them single point incremental forming operations, in which the final shape of the component is obtained by the relative movement of a simple and small punch with respect to the blank, appear quite promising. In the paper, material formability issues in incremental forming were studied. Some relevant correlations among material formability and other mechanical properties of the material were analysed. The FLD 0 value, i.e. the major strain at fracture in plane strain conditions, was determined for different materials and the influence of the main material parameters on formability was accurately investigated through a statistical analysis.
- Published
- 2004
180. Enhancing formability of aluminium alloys by superimposing hydrostatic pressure
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Fabrizio Micari, Livan Fratini, Luigino Filice, Filice, L., Fratini, L., and Micari, F.
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FEM ,Materials science ,Upsetting ,Material formability ,Metallurgy ,Hydrostatic pressure ,Microvoid ,Titanium alloy ,chemistry.chemical_element ,Forming processes ,Mechanical engineering ,Forging ,Engineering (all) ,chemistry ,Aluminium ,Damage mechanics ,Formability ,Ductility ,Damage mechanic - Abstract
Publisher Summary One of the strategic topics in manufacturing engineering is represented by the reduction of components weight. This aim is pursued by utilizing accurate and effective design tools and using lightweight metals such as aluminum, magnesium, and titanium alloys. Unfortunately, such materials often show a poor ductility, and thus enhancing formability is nowadays one of the most relevant research focus, as well as the development of effective and reliable predictive models of defects insurgence during forming processes. In this scenario, forming by means of superimposed hydrostatic pressure represents a promising alternative manufacturing technique. The chapter discusses the simple upsetting process of AA6082-T6 cylindrical specimens under sticking conditions at the punch-specimen interface. The process is simulated and experimentally carried out both with and without a superimposed hydrostatic pressure. The experimental equipment is designed with the aim to achieve an assigned fluid pressure value inside the chamber during the upsetting process.
- Published
- 2003
181. An Experimental Investigation of Residual Stresses in Hard Machining of AISI 52100 Steel
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José Outeiro, Luigino Filice, Domenico Umbrello, Serafino Caruso, Fabrizio Micari, Veritati - Repositório Institucional da Universidade Católica Portuguesa, Umbrello, D, Caruso, S, Outeiro, JC, Filice, L, and Micari, F
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Diffraction ,Materials science ,Metallurgy ,Residual stress ,General Medicine ,Surface integrity ,Hard machining ,Residual stresses ,Machined surface ,Machining ,Cutting ,Phase (matter) ,Settore ING-IND/16 - Tecnologie E Sistemi Di Lavorazione ,Engineering(all) - Abstract
In this paper an experimental investigation was conducted to determine the effects of the tool cutting-edge geometry, workpiece hardness, cutting speed, and microstructural changes (white and dark layers) on the residual stresses in dry orthogonal hard machining of AISI 52100 steel. X-ray diffraction technique was used to obtain in-depth residual stresses profiles in both axial and circumferential directions. The results show that tool geometry, workpiece hardness and cutting parameters significantly affect the surface residual stress, maximum compressive residual stress below the machined surface and its location. Moreover, microstructural analysis shows that thermally-induced phase transformations have a significant impact on the magnitude and location of this maximum compressive residual stress peak.
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182. On the FE codes capability for tool temperature calculation in machining processes
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Stefano Beccari, Domenico Umbrello, Luigino Filice, Fabrizio Micari, FILICE L, UMBRELLO D, BECCARI S, and MICARI F
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Work (thermodynamics) ,Engineering ,Computer simulation ,business.industry ,Metals and Alloys ,Mechanical engineering ,Industrial and Manufacturing Engineering ,Finite element method ,Computer Science Applications ,Machined surface ,Machining ,Thermocouple ,Residual stress ,Modeling and Simulation ,Thermal ,Ceramics and Composites ,business - Abstract
The applications of numerical simulation to machining processes have been more and more growing in the last years: today a quite effective predictive capability has been reached, at least as far as global cutting variables (for instance cutting forces) are concerned. On the other hand, the capability to predict local cutting variables (i.e. pressure on the tool, temperature distribution, residual stresses in the machined surface) has to be heavily improved and verified. At the same time, effective experimental procedures for validating numerical results have to be developed. In this work two different approaches were implemented for temperature measuring: a thermocouple based approach and a thermographic analysis were developed. As well the effectiveness of a couple of typologies of numerical simulation was investigated; the former was a 2D fully thermo-mechanical analysis, the latter a 3D pure thermal one. The results of the study permit to assess that a thermo-mechanical simulation does not permit a satisfactory temperature prediction, while an integrated approach including analytical models and pure thermal FE simulations promises relevant advantages.
183. Hybrid Nanoparticles Based on Mesoporous Silica and Functionalized Biopolymers as Drug Carriers for Chemotherapeutic Agents.
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Curcio F, Sanguedolce M, Filice L, Testa F, Catapano G, Giordano F, Trombino S, and Cassano R
- Abstract
Mesoporous silica nanoparticles (MSNs) are promising drug carriers for cancer therapy. Their functionalization with ligands for specific tissue/cell targeting and stimuli-responsive cap materials for sealing drugs within the pores of MSNs is extensively studied for biomedical and pharmaceutical applications. The objective of the present work was to establish MSNs as ideal nanocarriers of anticancer drugs such as 5-FU and silymarin by exploiting characteristics such as their large surface area, pore size, and biocompatibility. Furthermore, coating with various biopolymeric materials such as carboxymethyl chitosan-dopamine and hyaluronic acid-folic acid on their surface would allow them to play the role of ligands in the process of active targeting to tumor cells in which there is an overexpression of specific receptors for them. From the results obtained, it emerged, in fact, that these hybrid nanoparticles not only inhibit the growth of glioblastoma and breast cancer cells, but also act as pH-responsive release systems potentially useful as release vectors in tumor environments.
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- 2024
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184. Workforce and supply chain disruption as a digital and technological innovation opportunity for resilient manufacturing systems in the COVID-19 pandemic.
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Ambrogio G, Filice L, Longo F, and Padovano A
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During the SARS-CoV-2 pandemic (also known as COVID-19), workforce downsizing needs, safety requirements, supply chain breaks and inventory shortages affected manufacturing systems' and supply chain's responsiveness and resilience. Companies wandered in a disrupted scenario because recommended actions/strategies to survive - and thrive - were not available an improvised actions to keep their operations up and running. This paper analyzes the COVID-19 impacts on the workforce and supply resilience in a holistic manner. The following research questions are discussed: (i) how can manufacturing firms cope with urgent staff deficiencies while sustaining at the same time a healthy and safe workforce in the perspective of socially sustainable and human-centric cyber-physical production systems?; (ii) is remote working (cf. smart working) applicable to shop-floor workers?; (iii) is it possible to overcome supply chain breaks without stopping production? In the first part, we propose three Industry 4.0-driven solutions that would increase the workforce resilience, namely: (i) the Plug-and-Play worker ; (ii) the Remote Operator 4.0 ; (iii) the Predictive Health of the Operational Staff . In the second part, the concepts of (i) Digital & Unconventional Sourcing , i.e. Additive Manufacturing, and (ii) Product/Process Innovation are investigated from a novel business continuity and integration perspective. We ultimately argue that forward-looking manufacturing companies should turn a disruptive event like a pandemic in an opportunity for digital and technological innovation of the workplace inspired by the principles of harmonic digital innovation (that places the human well-being at the center). These aspects are discussed with use cases, system prototypes and results from research projects carried out by the authors and real-world examples arising lessons learned and insights useful for scientists, researchers and managers., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2022 Elsevier Ltd. All rights reserved.)
- Published
- 2022
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185. Mechanical and microstructural characterization of titanium gr.5 parts produced by different manufacturing routes.
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Campanella D, Buffa G, El Hassanin A, Squillace A, Gagliardi F, Filice L, and Fratini L
- Abstract
Since a few decades, the aircraft industry has shifted its preference for metal parts to titanium and its alloys, such as the high-strength titanium grade 5 alloy. Because of titanium grade 5 limited formability at ambient temperature, forming operations on this material requires high temperatures. In these conditions, a peculiar microstructure evolves as a result of the heating and deformation cycles, which has a significant impact on formability and product quality. On the other hand, additive manufacturing technologies, such as selective laser melting and electron beam melting, are increasingly being used and are replacing more traditional approaches such as machining and forging. Fundamental part characteristics such as mechanical and microstructural properties, geometric accuracy, and surface quality strongly depend on the selection of the manufacturing method. The authors of this paper seek to identify the strengths and limitations imposed by the intrinsic characteristics of different manufacturing alternatives for the production of parts of aeronautical significance, providing guidelines for the choice of the most appropriate manufacturing route for a given application and part design., Competing Interests: Competing interestsThe authors no competing interests., (© The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.)
- Published
- 2022
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186. Biomaterials and Adipose-Derived Mesenchymal Stem Cells for Regenerative Medicine: A Systematic Review.
- Author
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Alonso-Goulart V, Carvalho LN, Marinho ALG, de Oliveira Souza BL, de Aquino Pinto Palis G, Lage HGD, de Lima IL, Guimarães LD, Peres LC, Silveira MM, Lopes GHNL, Ferreira LB, and de Souza Castro-Filice L
- Abstract
The use of biological templates for the suitable growth of adipose-derived mesenchymal stem cells (AD-MSC) and "neo-tissue" construction has exponentially increased over the last years. The bioengineered scaffolds still have a prominent and biocompatible framework playing a role in tissue regeneration. In order to supply AD-MSCs, biomaterials, as the stem cell niche, are more often supplemented by or stimulate molecular signals that allow differentiation events into several strains, besides their secretion of cytokines and effects of immunomodulation. This systematic review aims to highlight the details of the integration of several types of biomaterials used in association with AD-MSCs, collecting notorious and basic data of in vitro and in vivo assays, taking into account the relevance of the interference of the cell lineage origin and handling cell line protocols for both the replacement and repairing of damaged tissues or organs in clinical application. Our group analyzed the quality and results of the 98 articles selected from PubMed, Scopus and Web of Science. A total of 97% of the articles retrieved demonstrated the potential in clinical applications. The synthetic polymers were the most used biomaterials associated with AD-MSCs and almost half of the selected articles were applied on bone regeneration.
- Published
- 2021
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187. Bisphosphonate-associated osteonecrosis of the jaw.
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Ferreira Jr LH Jr, Mendonça Jr KD Jr, Chaves de Souza J, Soares Dos Reis DC, do Carmo Faleiros Veloso Guedes C, de Souza Castro Filice L, Bruzadelli Macedo S, and Soares Rocha F
- Subjects
- Diphosphonates, Humans, Risk Factors, Bisphosphonate-Associated Osteonecrosis of the Jaw, Osteonecrosis, Osteoporosis
- Abstract
Introduction: The purpose of this systematic review was to determine the possible risk factors related to pathophysiology of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and identify adequate treatment strategies available and success rates., Evidence Acquisition: We performed a search for publications about the treatment of BRONJ, published between 2003 and 2018 in the PubMed/Medline data base using the key words: "Bisphosphonate-Associated Osteonecrosis of the Jaw" OR "Bisphosphonate Osteonecrosis" OR "BRONJ", based on the list of MeSH and DeCS., Evidence Synthesis: According to pre-established criteria for data collection concerning the treatment of BRONJ, we found 19 articles covering a total of 400 patients. Treatments that showed good outcomes were Ozone, PRF, PRP/Debridement/Laser bio-stimulation, Laser surgery and Laser surgery/Laser bio-stimulation. HBO did not achieve good results and was used in only 10 patients. BRONJ is a rare condition in patients with osteoporosis/other pathologies using BP orally. These patients had long exposure time and cumulative doses of BPs until onset of the lesion. The oncological patients were exposed to more potent intravenously administered BPs such as pamidronate and zoledronate. These patients had a shorter exposure time until onset of the lesion., Conclusions: The treatment of BRONJ is still under debate and there are promising treatments that need randomized trials with larger numbers of patients to confirm their results. Patients receiving BPs or those who will start treatment should be encouraged to perform preventive dental treatment and maintain good oral hygiene.
- Published
- 2021
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188. The effect of hyperbaric oxygen therapy on bone macroscopy, composition and biomechanical properties after ionizing radiation injury.
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Júnior LHF, Limirio PHJO, Soares PBF, Dechichi P, de Souza Castro Filice L, Quagliatto PS, and Rocha FS
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- Animals, Biomechanical Phenomena, Bone Matrix pathology, Bone Matrix radiation effects, Bone and Bones radiation effects, Male, Osteogenesis radiation effects, Radiation, Ionizing, Rats, Rats, Wistar, Tibia pathology, Tibia radiation effects, Bone and Bones pathology, Hyperbaric Oxygenation, Radiation Injuries therapy
- Abstract
Background: Radiotherapy used in tumor treatment compromises vascularization of bone tissue. Hyperbaric oxygenation (HBO) increases oxygen availability and improves vascularization, minimizing the deleterious effects of ionizing radiation (IR). Therefore, the aim of this study was to evaluate HBO therapy effect on bone macroscopy, composition and biomechanical properties after IR damage., Methods: Twenty male Wistar rats weighing 300 ± 20 g (10 weeks of age) were submitted to IR (30 Gy) to the left leg, where the right leg was not irradiated. After 30 days, ten animals were submitted to HBO therapy, which was performed daily for 1 week at 250 kPa for 90-min sessions. All animals were euthanized 37 days after irradiation and the tibia were separated into four groups (n = 10): from animals without HBO - right tibia Non-irradiated (noIRnoHBO) and left tibia Irradiated (IRnoHBO); and from animals with HBO - right tibiae Non-irradiated (noIRHBO) and left tibia Irradiated (IRHBO). The length (proximal-distal) and thickness (anteroposterior and mediolateral) of the tibiae were measured. Biomechanical analysis evaluated flexural strength and stiffness. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) was used to calculate the amide I ratio, crystallinity index, and matrix to mineral ratios., Results: In the macroscopic and ATR-FTIR analysis, the IRnoHBO showed lower values of length, thickness and amide I ratio, crystallinity index and matrix to mineral ratios compared to noIRnoHBO (p < 0.03). IRnoHBO showed no statistical difference compared to IRHBO for these analyses (p > 0.05). Biomechanics analysis showed that the IRnoHBO group had lower values of flexural strength and stiffness compared to noIRnoHBO and IRHBO groups (p < 0.04). In addition, the noIRHBO group showed higher value of flexural strength when compared to noIRnoHBO and IRHBO groups (p < 0.02)., Conclusions: The present study concluded that IR arrests bone development, decreases the collagen maturation and mineral deposition process, thus reducing the flexural strength and stiffness bone mechanical parameters. Moreover, HBO therapy minimizes deleterious effects of irradiation on flexural strength and the bone stiffness analysis.
- Published
- 2020
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189. Experimental Characterization of the Torsional Damping in CFRP Disks by Impact Hammer Modal Testing.
- Author
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Cosco F, Serratore G, Gagliardi F, Filice L, and Mundo D
- Abstract
Composite materials are widely used for their peculiar combination of excellent structural, mechanical, and damping properties. This work presents an experimental study on the dissipation properties of disk-shaped composite specimens exploiting vibration tests. Two different polymer matrix composites with the same number of identical laminae, but characterized by different stacking sequences, namely unidirectional and quasi-isotropic configurations, have been evaluated. An ad-hoc steel structure was designed and developed to reproduce an in-plane torsional excitation on the specimen. The main idea of the proposed approach relies on deriving the damping properties of the disks by focusing on the modal damping of the overall vibrating structure and, in particular, using just the first in-plane torsional deformation mode. Experimental torsional damping evaluations were conducted by performing vibrational hammer excitation on the presented setup. Two methods were proposed and compared, both relying on a single-degree-of-freedom (SDOF) approximation of the measured frequency response function (FRF)., Competing Interests: The authors declare no conflict of interest.
- Published
- 2020
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190. A novel missense mutation in the MYH7 gene causes an uncharacteristic phenotype of myosin storage myopathy: a case report.
- Author
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Mamelona J, Filice L, Oussedik Y, Crapoulet N, Ouellette RJ, and Marrero A
- Subjects
- Adult, Child, Female, Humans, Middle Aged, Muscular Diseases genetics, Phenotype, Cardiac Myosins genetics, Muscular Diseases congenital, Mutation, Missense, Myosin Heavy Chains genetics
- Abstract
Background: Few manuscripts have reported phenotypes of skeletal muscle myopathies caused by mutations in the head region of slow/cardiac beta-myosin heavy chain (MyHCI). Among the patients, some of them showed the phenotype of skeletal muscle weakness with the obvious clinical features of cardiomyopathy while others showed pure skeletal muscle weakness with no symptoms of cardiac involvement. Genotype-phenotype relationship regarding the effect of a mutation on MyHCI is complex. Questions regarding why some mutations cause cardiomyopathy or skeletal muscle disorders alone or a combination of both still need to be answered. More findings in genetic variation are needed to extend knowledge of mutations in the MYH7 gene linked to skeletal muscle disorders., Case Presentation: Here we present a female adult patient with a phenotype of childhood onset of muscular disorders and predominant involvement of thigh muscles with biopsy showing intrasarcoplasmic inclusion bodies. Whole exome sequencing showed that variant c.1370 T > G (p.Ile457Arg) in the MYH7 gene is a missense mutation possibly linked to the clinical findings. Our patient likely shows an uncharacteristic myosin storage myopathy associated with respiratory and cardiac involvement linked to a missense mutation in the head of MyHCI., Conclusions: Given this mutation is located within the motor domain of MyHCI, this might affect the regulation of myosin mechano-chemical activity during the contractile cycle. Consequently, this potentially damaging effect can be easily amplified within the network of ~ 300-myosin molecules forming the thick filament and therefore become cumulatively deleterious, affecting, in turn, the overall organization and performance of sarcomere.
- Published
- 2019
- Full Text
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