301. Inhibitory effect of pyrophosphate, citrate, magnesium and chondroitin sulphate in calcium oxalate urolithiasis.
- Author
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Grases F, Genestar C, Conte A, March P, and Costa-Bauzá A
- Subjects
- Calcium Oxalate urine, Chondroitin, Citric Acid, Crystallization, Humans, Urinary Calculi urine, Chondroitin Sulfates therapeutic use, Citrates therapeutic use, Diphosphates therapeutic use, Magnesium therapeutic use, Urinary Calculi prevention & control
- Abstract
The inhibitory capacity of pyrophosphate, citrate, magnesium and chondroitin sulphate was investigated, using the urine of 21 calcium oxalate stone-forming patients without metabolic alterations. The inhibitory effect of these substances was assessed by a combination of nephelometry (light scattering) and optical microscopy. The results showed that citrate and magnesium had an inhibitory effect in a significant number of cases. Pyrophosphate and chondroitin sulphate had a less marked effect. The main urinary lithogenic biochemical parameters of the patients were also studied to see if there was a relationship between them and the inhibitory capacity of the compounds.
- Published
- 1989
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