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Background. Membranous nephropathy (MN) is an immunocomplex glomerular disease, which is the most common cause of nephrotic syndrome in adults. Numerous studies have established that autoantibodies against the target podocyte autoantigens, including the thrombospondin type 1 domain containing 7A (THSD7A), play a leading role in the development of idiopathic MN. Aim. To evaluate the prevalence of anti-THSD7A autoantibodies (anti-THSD7A AB) in a group of Russian patients with MN. Materials and methods. Serum titers of anti-THSD7A AB were tested in 61 patients with biopsy-proven MN and 12 healthy controls. Results. The prevalence of anti-THSD7A AB was not differing significantly in patients with MN and in the control group (110.9 [71.63; 210.62] and 159.25 [125.64; 231.97] pg/ml, respectively; p=0.111). When comparing subgroups of anti-PLA2R-negative patients and patients who did not receive immunosuppressive therapy with the control group, there were also no statistically significant differences in the Anti-THSD7A AB levels (p0.05). In the MN group, 1 (1.6%) patient was anti-THSD7A-positive: a 60-year-old man with anti-PLA2R-negative MN and the presence of hormonally inactive adenomas of both adrenal glands and colon polyps (villous adenoma with focal moderate dysplasia, tubulo-villous and tubular adenoma with focal moderate severe dysplasia). Conclusion. THSD7-associated MN is a rare variant of MN and is usually detected in PLA2R-negative patients. Screening for malignancies in THSD7A-positive MN patients is proposed.

Reproductive health care involves helping families in this area with the provision of the necessary information. This is recognized as a key step in improving the health of men, women and children and is a fundamental human right. Everyone has the right to have access to a correct understanding of reproductive health care, choice of contraceptive method and the opportunity to benefit from scientific progress in this area. Over the past 35 years, significant progress has been made in the development of new contraceptives: the content of hormones in combined oral contraceptives has significantly decreased, inert intrauterine contraceptives have been replaced by more progressive, levonorgestrel-containing ones including low-dose generation. Combined hormonal compounds were synthesized in the form of injections, patches and vaginal rings, progestogen implantable and injectable contraceptives. Women who use contraceptives must take into account the state of health (including the presence of endocrine pathology) in order to use them without harm to their health. Based on the World Health Organization Medical Eligibility Criteria for Contraceptive Methods 2015, the Russian Medical Eligibility Criteria for Contraceptive Methods 2023 is designed to become an important tool in daily practice of doctors.

The plans announced by the European Union to impose a carbon fee by 2022 on commodities purchased from both European and external manufacturers make it increasingly relevant to examine the adaptation of Russian and European companies to low-carbon requirements. The article aims to assess the financial technological costs, technological achievements and energy transition risks for enterprises in Russia and the EU. Theoretical approaches to analyzing technological effects of carbon requirements on enterprises constitute the methodological framework of the study. The research methods of comparative qualitative and quantitative analysis were used in relation to technologies introduced by European and Russian large companies, reached values and dynamics of the carbon footprint in manufacturing, energy consumption, the percentage of renewable energy, the size of costs and investments, projected parameters of traditional energy, the EU plans, and the cost price of alternative energy. The empirical evidence includes public reports of European and Russian exporting companies affected by the carbon fee introduction, as well as microeconomic statistics. The analysis showed that both European and Russian major exporters by the end of 2021 had already initiated certain efforts to reduce their carbon footprint and achieved satisfactory outcomes in this area. In some cases, the Russian companies were even more successful than the European ones, but in general they lagged behind. However, expenses of the European companies are more significant, and energy transition risks for them are higher, which significantly reduces the dividend received by the leader. We propose recommendations to protect Russian business, including export-oriented one, from excessive costs incurred in the development of low-carbon energy. These recommendations can be of use for authorities when implementing industrial policy.

The article examines the main features of the individual style of the American science fiction writer Ted Chiang and the peculiarities of their translation into Russian language. The relevance is related to the fact that the individual style of the writer has not yet become a subject of study, despite popularity of his works. The problem of author’s style in translation is critical as there is no unanimity on criteria to define style-forming elements of author’s style. The purpose of the study is to identify the main features of the author’s individual style and their forming factors, as well as the ways to translate them into Russian. For this we analyze the genre affiliation of the work, writer’s sphere of interest, ideological and thematic components, characters’ images and stylistic means, the type of narration, as well as the translation in terms of preserving or transforming these features. The material: T. Chiang’s sort novel Story of Your Life (2002). Results of the study: by textual comparison we define T. Chiang’s style elements and show that some of them are extralinguistic, also we describe their translation strategies.

Increasing prospective phytochemical investigations and biological activities on Pueraria lobata and Trifolium pratense flowers exhibited their nutritional (food industry) pharmaceutical (anticancer, anti-inflammatory, anti-microbial, etc.) potentials. Previous studies paid great attention to the screening of isoflavones profile from phytochemicals. This study, in contrast, aimed at identifying the flavonoids from Pueraria lobata flowers or kudzu flower (KF) and Trifolium pratense flowers or red clover (RC) flowers and determining their cytotoxic activities on normal; (HEK-293) and cancer cell lines; human glioblastoma (A-172), osteosarcoma (HOS), embryonic rhabdomyosarcoma (Rd), lung carcinoma (A-549) and liver carcinoma (HepG2). The phytochemical screening using a high-performance liquid chromatography-diode array detector coupled with quadrupole time-of-flight mass spectrometry (HPLC-DAD-Q-TOF/MS) showed that 15 flavonoids, including isoflavones, flavones, flavonols, and flavanones, were identified in KF and 8 flavonoids, including isoflavones and flavonols, were found in RC. Nevertheless, the majority of flavonoid chemical constituents in KF or RC were found to be isoflavones (66.6%) and (62.5%), respectively. HPLC-DAD analysis following eco-friendly extraction of phytochemicals showed that KF contains mainly daidzein and genistein, while RC contains primarily formononetin and biochanin A. Cytotoxic activities evaluated according to IC50 values exhibited the most pronounced dose-dependent antiproliferative effect of KF and RC extracts were against HOS and Rd cancer cell lines, respectively. Accordingly, the morphological observation carried out using acridine orange/ethidium bromide and Giemsa stains revealed apoptotic activities and cell death in HOS and Rd cell lines when subjected to KF or RC extracts. Cytotoxic activities and apoptotic changes were pronounced among all cancer cell lines except for the control cells (HEK-293). Additionally, various polyphenols and flavonoids were identified and quantified in KF and RC extracts and exhibited potent radical scavenging activities. Overall, this study suggests that KF and RC could be valuable edible sources of flavonoids. The comprehensive flavonoid profiles for KF and RC may explain their remarkable biological activities and contribution to inducing antioxidant and cytotoxic activities against cancer cell lines.

This article is devoted to the concepts of gastronomic discourse, given by foreign and Russian scientists, and the analysis of the features of Russian and Chinese cooking videos. The aim of the article was to identify some features of subtitling gastronomic videos. The material of the study was a cooking video in Chinese, available on YouTube. We applied methods of discourse analysis, semantic analysis, component analysis, and comparison and collation method within the specified language pair. During the study, such difficulties as difference in the number of symbols, the polysemy of words, the translation of proper names and ingredients-realia, and different language transformations such as addition, omission, compression and literal translation were considered. Each difficulty found its solution according to the specifics of cooking topic and subtitling.

Purpose. The manuscript is devoted to the burning issue of education internationalization in modern society. Having come to study in Russia, many international students face a number of difficulties concerning various aspects of their life activity. The authors aim to study international students’ opinion regarding their residence in the European North and their study at the Russian medical university. Methodology. Survey findings of 149 Indian students studying at the International Faculty of General Practitioners of the Northern State Medical University (NSMU), Arkhangelsk compose the research basis. Results. Main challenges encountered by international students in the conditions of the European North, their attitude to the organization and quality of the educational process in the university were revealed. Cold climate, language barrier, the lack of traditional foods and separation from family are believed to be the main factors that make it difficult for junior students to learn. Senior students express their disappointment at the lack of clinical practice due to the distance learning during the pandemic and different level of students and teachers’ language proficiency. In general, students speak positively about university educational process and are satisfied with Russian education quality. Practical implications. Research findings can be used to develop recommendations for improving the socio-pedagogical adaptation of international students in Russian universities.

Background. The ongoing pandemic of the novel coronavirus infection (COVID-19) draws attention to the significance of molecular and genetic monitoring of the SARS-CoV-2 spread among the population of the Russian Federation. The aim of the study was to analyze the dynamics of circulation of SARS-CoV-2 genetic variants in Russia. Materials and methods. The analysis of the circulation dynamics for SARS-CoV-2 genetic variants in Russia was carried out, covering the period from 28/12/2020 to 26/6/2022. The analysis included the data from Rospotrebnadzor Report No. 970 "Information about Infectious Diseases in Individuals with Suspected Novel Coronavirus Infection" and the Virus Genome Aggregator of Russia (VGARus). The presence of SARS-CoV-2 RNA was confirmed by the real-time reverse transcription polymerase chain reaction. The primer panels developed at the Central Research Institute of Epidemiology were used for amplification of genomic fragments and the subsequent sequencing. Results and discussion. Using the Russian VGARus platform developed by the Central Research Institute of Epidemiology, we received the data on mutational variability of SARS-CoV-2. By monitoring the circulation of SARS-CoV-2 genetic variants in Russia from 28/12/2020 to 26/6/2022, we found that Delta and Omicron genetic variants prevailed at different stages of the epidemic. Conclusion. The data of molecular and genetic studies are an essential component of epidemiological surveillance, being critically important for making executive decisions aimed at prevention of further spread of SARS-CoV-2 and laying the groundwork for creating new vaccines.

The article identifies and argues the need for the development of international tourism as one of the elements of the mechanism for overcoming the raw material orientation of exports of the KHMAO-Yugra through the analysis and synthesis of the above and generalized factual and statistical materials of the authors of scientific papers of similar and related areas, which necessitate the diversification of exports of the oil and gas producing region by developing the tourism services industry on the world market. Based on the analysis of the material presented in this article, the current characteristics of the situation in Yugra are given, recommendations are given on the directions of development of international tourism in the district. The main provisions and conclusions of the article can be used in the scientific and practical activities of the regional authorities when considering issues of export diversification through the development of international tourism. Purpose is to substantiation of the need for the development of international tourism as one of the tools to overcome the raw materials orientation of the export of KhMAO-Yugra and the development of its neo-industrial specialization Methodology. The opinion and conclusions of the authors are formed through the analysis and synthesis of the above and generalized factual and statistical materials, the authors of scientific works of related areas that necessitate the diversification of exports of the oil and gas producing region through the development of the tourism services industry (inbound tourism). Results. During the analysis of inbound tourism as one of the areas of export diversification, some problems were found. The analysis, assessment of the tourist region of Khanty-Mansiysk Autonomous Okrug and substantiation of the main factors and problems that limit the volume of internal and external tourist flows allows us to formulate ways to solve their implementation for the expanded Autonomous Okrug in the field of ethno-tourism. All this gives rise to the prerequisites for the development of business, cultural, educational, ethnographic, ecological, sports, water, active, health-improving, developed and auto tourism. Practical implications. The results of this study can be applied in the scientific and practical activities of regional authorities in addressing issues of export diversification, including through the development of international tourism, will contribute to the development of this area, as well as consideration of other promising ways to diversify exports of goods and services.

Life in a modern metropolis is not only an interesting and eventful life, but also a source of numerous features for human life: imperfect environmental conditions, dietary habits, sleep disturbances and circadian rhythms, changes in psychological status (stress, depression, aggression, apathy) and reproductive health problems, especially in women. As defined by the World Health Organization, reproductive health is a state of complete physical, mental and social well-being, and not simply the absence of disease in all areas related to the reproductive system, its functions and processes. Life in a big city for a woman of the reproductive period is often accompanied by a violation of the menstrual and ovulatory function, which can be attributed to the symptoms of the megalopolis syndrome. Since the 1980s, the frequency of menstrual irregularities has increased by more than 7 times. The doctor clinician, to whom a woman of the reproductive period with an irregular menstrual cycle first turns, should not only draw up a plan for examining a woman and exclude the presence of endocrine-gynecological disorders, but also collect a detailed history, including physical status (for example, calculating body mass index, analyzing fluctuations weight), dietary habits, sports history, medication intake, first assess the role of the psychosomatic factor. The correct pathogenetic approach in this situation will determine the correct therapeutic tactics for managing a woman.

The problem of export diversification remains pressing for Russia, which needs to increase the share of the non-resources exports, and in particular, the share of higher valueadded products. The paper aims to examine the spatial differentiation of the Russian exports by various entities (federal districts, regions, top exporting companies), including in the sectoral context, and for the latter considers the most important machines and equipment sector. The methodological basis of the research rests on regional and spatial economics and theories of foreign economic activity. The paper applies economic-statistical methods, including the corre lation analysis. The authors examine Russia and its regions’ exports for 2013–2018 based on the data of Russia’s Federal State Statistic Service and Federal Customs Service and reveal “consist ency” between production and export of mechanical engineering products in the four groups of regions. The analysis demonstrates high importance of the resources export for the national economy and high spatial differentiation of exports, including of the non-resources ones. Dur ing 2013–2018, the mechanical engineering production and export grew in 27 regions, how ever, on average, high-tech production is more focused on the domestic market. The analysis confirms the significance of export as a channel of production preservation and can serve as a contribution to justify the necessity to develop the new industrial export specialisation. The results of the research can be of use to the institutions of economic development (government authorities) to outline the perspectives of the regional development of export.

Due to rapid technological changes, there is a need to consider the digitalization of the economy as a global competition tool, especially in regards to non-resource export. The study examines the relationship between the total regional export of technological products and digitalization of the Russian economy. We hypothesise that the developing digitalization of business effectively increases the regional export of technological products. As the methodological basis, we focus on various theoretical approaches of foreign and Russian authors to assessing the digitalization impact on the development of national and regional economies. For assessing that impact, we created a model that evaluates the correlation between the export of technological products and probable impact factors, including an integrated digitalization index. The author’s typology of the Russian regions allowed identifying the differences in their digitalization processes. The research method is the regression analysis that includes the ordinary least squares method. We tested the research model on the data of Federal State Statistic Service and Federal Customs Service for 2018. As a result, we determined four types of regions and confirmed that digitalization is a driver of their economic development: the level of digitalization influences the global competitiveness of the regions, including high-tech exports. The model can be considered as a tool for analysing and predicting the development of technological export for 4 types of regions. For each type, we described possible development strategies, aimed at overcoming the limitations in technological export, taking into account the digitalization of business. Authorities and companies competing for new strategic markets can apply the research findings for developing and implementing the mechanisms and tools of digitalization in order to ensure the leadership of the regions in terms of technological export.

The Central Research Institute of Epidemiology of Rospotrebnadzor presents priority data obtained from the largescale population PCR-based study of the changes in the rates of circulation of SARS-CoV-2 among relatively healthy residents of Moscow and Moscow Region.

Obesity is a recurring polyetiological disease. Overweight are 30–60% of women of reproductive age, and 25–27% are obese. By 2025, it is expected that 50% of women on our planet will be obese. Obesity in women of reproductive age is accompanied by a high frequency of anovulation, hyperandrogenism, menstrual irregularities, endometrial pathology, infertility. During pregnancy, this group of women has a higher risk of short term loss, including pregnancy in the outcome of assisted reproductive technologies. Weight gain and obesity can lead to decreased fertility in women. The body mass index of a woman of reproductive age negatively affects the course of pregnancy, namely: the risk of gestational diabetes, increased blood pressure, eclampsia, the pathological course of the birth act and the pathology of the newborn increase. Obesity in women of reproductive age is an independent risk factor for cancer: breast cancer and endometrial cancer, and also leads to a decrease in the survival rate for ovarian cancer. Obesity often accompanies polycystic ovary syndrome, which occurs in every 10th patient of reproductive age. The combination of these diseases increases the risk of cardiometabolic conditions such as impaired glucose tolerance, type 2 diabetes and dyslipidemia. Weight loss in these patients is a necessary component of complex therapy aimed at improving reproductive potential.

BACKGROUND: One of the consequences of obesity for the female body is a decrease in fertility. It is shown that impaired reproductive function in obese patients can be associated, in particular, with a decrease in ovarian reserve. AIMS: To evaluate the ovarian reserve function in female patients of reproductive age with different classes of obesity in comparison with women without obesity. MATERIALS AND METHODS: This study evaluated 320 caucasian women, age 20-30 years, without obesity (BMI

The review article presents data on the effects of obesity on the female reproductive system and offspring of mothers with overweight or obesity, such as infertility, miscarriages, premature birth, stillbirth, congenital anomalies and prematurity, as well as a high risk of cesarean section. Obesity accompanies polycystic ovary syndrome, worsening the metabolic profile and increasing the risk of developing depression and eating disorders. Maternal obesity and hyperglycemia are able to influence the formation of the fetus by epigenetic mechanisms without affecting the nucleotide sequences. Subsequently, the metabolic and cardiovascular risks increase in the descendants of obese or overweight mothers and gestational diabetes. Patients with obesity are characterized by a folic acid deficiency and a deficiency of the luteal phase. Exogenous administration of these substances improves pregnancy outcomes and prevents congenital malformations.

Present literature review provides information about clinical trials that evaluated the association of the carriage of antithyroid antibodies (ATA) and the reduction of the ovarian reserve, as well as the effectiveness of assisted reproductive technologies. The ambiguity and sometimes the opposite of the conclusions of different authors, makes it possible to recommend a balanced attitude to the advisability of screening for ATA in women with a reproductive dysfunction as well as the therapeutic measures proposed in some guidelines based on the results of such examination.

The article reveals the trends in foreign economic development of Russian and American pharmaceutical industry. The study aims to substantiate the trends of prevailing import dependence of Russian pharmaceutical sector and export orientation of American one. Moreover, we define the main directions of export in Russian pharmaceutical industry based on the development trends of world industry leaders. We focus on identifying what is the nature and how close is the relationship between the factors of business’ innovation and complexity, on the one hand, and increasing the sector’s export orientation, on the other hand. The research methodology is based on the domestic and foreign literature on foreign economic activity in pharmaceutical industry. Furthermore, the methods include the pharmaceutical industry assessment by international institutions (particularly, the World Economic Forum). We used the data from United Nations Conference on Trade and Development (UNCTAD) statistics, American and Russian international ratings, and the results of analytical studies of innovation processes in bio-pharm-medical sector. We hypothesise that there is a correlation between the factors of business innovations and maturity, and the volume of pharmaceutical industry export. The correlation analysis has revealed the relation between innovation development and export growth, suggesting the export’s integration into the national strategy of pharmaceutical industry. The comparative analysis of the Russian and American pharmaceutical industries has demonstrated that the increase in the export-oriented products in Russian pharmaceutical industry will be determined by the degree of the integration of information technologies into all stages of research and pharmaceutical business. The developers and ideologists of national export strategy in pharmaceutical industry might implement the study’s conclusions and recommendations on federal and regional levels. Further scientific research should focus on substantiating ways to increase the pharmaceutical industry’s competitiveness, corresponding to the fundamental information, technological and personnel challenges of this industry development.

Premenstrual syndrome is defined as a combination of physical and mental symptoms that have a significant impact on a woman’s quality of life and develop into the second phase of the menstrual cycle. Many patients have not been diagnosed, and therefore pathogenetic treatment is not carried out, although these complaints may disrupt the daily lives of patients and relationships with others. The article presents a review of the literature and studies that assessed the effectiveness of various treatment options (antidepressants, hormone therapy, lifestyle modification and herbal therapy).

The purpose of the research is to substantiate what kind of influence the import substitution has on the positioning of different types of regions in the system of international economic relations. The research is focused on two types of regions — the industrial type (the Sverdlovsk region) and the agricultural type (Rostov and Krasnodar regions). The research hypothesis is following: import substitution influences not only the replacement of imported goods by the domestic ones, but also can change regional positioning in the international economic relations system. The authors propose the methodological approach. It examines the regional economy according to three levels: a system of entities engaged in foreign economic activity; a system of the support of import substitution and export orientation in a region; a system of international economic relations. Regional positioning in the system of international economic relations is expressed in manufacture and agriculture exports and imports. Our methodological approach reveals the dependence between manufacture and agriculture exports and imports and the manufacturing and agriculture output, including correlation analysis. . We have offered a technique based on the comparative analysis of the effectiveness of import substitution in two regions’ types applying correlation analysis. The analysis has shown the interrelation of the development processes of domestic manufacturing and agriculture, their export and import in 2005– 2016. The import decrease and export increase (after 2014) were mainly due to regional specialization in international division of labour. This demonstrates the results of import substitution. The research results can be used for further development of the strategies of regional international economic activity including such instruments as import substitution and export promotion.

Background: The frequency of menstrual disorders in patients with acromegaly is 40–84% and are caused by three main reasons – the development of normal or hypogonadotropic hypogonadism due to hyperprolactinemia or a mass effect of the tumor and direct effects of GH and IGF-1 on the reproductive system. Nevertheless the exact mechanisms of reproductive dysfunction are not clear now. Hypothalamic structures play significant role in the regulation of hypothalamic-pituitary-ovary axis, so it’s important to study key neuropeptides and evaluate their effects to the pathogenesis of ovarian dysfunction during excessive secretion of growth hormone. Aim: The aim of the work is to study the hormonal regulation of menstrual function in patients of reproductive age with acromegaly in the active stage of the disease. Material and methods: The study included patients with a confirmed diagnosis of acromegaly and healthy women, comparable in age and BMI. Blood serum samples were taken in the morning (8–9 hours) on an empty stomach for 3–5 days of the menstrual cycle or on any day with amenorrhea and frozen at -70°C. The hormonal study was carried out by an enzyme immunoassay, in the case of a kisspeptin, with the preliminary extraction of serum samples. Results: The study included 31 patients with acromegaly and 15 healthy women. Between groups there was a statistically significant decrease in levels of LH (p = 0.001), FSH (p = 0.09), inhibin B (p = 0.003), and kisspeptin (p = 0.00005). The frequency of hyperprolactinemia in the cohort of patients was 51.6%. During the correlation analysis, a negative dependence of kisspeptin on the levels of GH and IGF-1 was detected (r = -0.54, p = 0.002 and r = -0.63, p = 0.0002). Conclusions: The severity of the central depression of regulation of menstrual function in patients with acromegaly may be due to the degree of disease activity.

Amyloids are protein aggregates with a highly ordered spatial structure giving them unique physicochemical properties. Different amyloids not only participate in the development of numerous incurable diseases but control vital functions in archaea, bacteria and eukarya. Plants are a poorly studied systematic group in the field of amyloid biology. Amyloid properties have not yet been demonstrated for plant proteins under native conditions in vivo. Here we show that seeds of garden pea Pisum sativum L. contain amyloid-like aggregates of storage proteins, the most abundant one, 7S globulin Vicilin, forms bona fide amyloids in vivo and in vitro. Full-length Vicilin contains 2 evolutionary conserved β-barrel domains, Cupin-1.1 and Cupin-1.2, that self-assemble in vitro into amyloid fibrils with similar physicochemical properties. However, Cupin-1.2 fibrils unlike Cupin-1.1 can seed Vicilin fibrillation. In vivo, Vicilin forms amyloids in the cotyledon cells that bind amyloid-specific dyes and possess resistance to detergents and proteases. The Vicilin amyloid accumulation increases during seed maturation and wanes at germination. Amyloids of Vicilin resist digestion by gastrointestinal enzymes, persist in canned peas, and exhibit toxicity for yeast and mammalian cells. Our finding for the first time reveals involvement of amyloid formation in the accumulation of storage proteins in plant seeds.

Background: Premature aging are frequently observed among individuals with type 1 diabetes. Decrease of ovarian reserve may be one of the characteristics of such process. Aims: To evaluate the ovarian reserve function in female patients of reproductive age with type 1 diabetes in comparison with healthy women. Materials and methods: This study evaluated 224 Caucasian women, age 18–37 years with type 1 diabetes and 230 healthy women of comparable age. Serum concentrations of anti-Mullerian hormone (AMH), inhibin B, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol, progesterone and testosterone were compared on the 2–3 day of menstrual cycle as ovarian volume and antral follicle count (AFC). In addition, glycated hemoglobin level (HbA1c%) was evaluated. Results: We reveal statistically significant difference in following parameters in diabetic women in comparison with healthy women: AMH, AFC. But even in diabetic patients parameters remained within reference ranges. There was a pronounced negative relationship between the levels of HbA1c% and AMG. Conclusions: Ovarian reserve function parameters decrease in young women with type 1 diabetes in comparison with healthy women, but ovarian reserve parameters are in normal reference range. These findings are important in pregnancy planning consulting by gynecologists and endocrinologists. We must recommend to women with type 1 diabetes more early planning of natural pregnancy for treatment with reproductive technology in cases of prolog absence of nature pregnancy.

In current geo-economic conditions, we need to consider the foreign economic factor as an instrument for structural changes, for the diversification of regional economy, as well as for the realization of a policy of import substitution, including exportoriented one. The article generalizes and systemizes preconditions and sources of the research of regional foreign economic activity in the works of the scientific school of the Institute of Economics of Ural Branch of RAS since the middle of the 1980s. The Institute was one of the first among the regional centres of the academic science of the country, which has addressed the foreign economic relations of a region. The purpose of the article is to systematize both the evolution of scientific definitions and the development of the Ural school of regional foreign economic research during the 30-years period. We apply the interdisciplinary approach and a broad range of methods: a historical method, an economic and statistical method, a comparative analysis, etc. The paper has systemized and characterized the research directions carried out by the staff of the Institute and in cooperation with Russian and Ural colleagues from other institutions. There are geo-economic shifts; international comparative research; regions’ involvement into global economic relations; realization of Ural export potential in terms of neo-industrialization and import substitution; international economic cooperation in the framework of SCO, BRICS, Eurasian Economic Union, etc. The Academician A. I. Tatarkin played an invaluable role as the Head of the Institute from 1990 to 2016. He initiated, facilitated and led many research directions. Thanks to this, the Institute of the Ural Branch of RAS over the years has being a kind of regional research-communicational platform, where scientists can search the mechanisms and tools for the realization of the foreign economic potential of the region with an account of national priorities. It underlines a high practical importance of the research in this sphere

The SARS-CoV-2 pandemic, which came to Russia in March 2020, is accompanied by morbidity level changes and can be tracked using serological monitoring of a representative population sample from Federal Districts (FDs) and individual regions. In a longitudinal cohort study conducted in 26 model regions of Russia, distributed across all FDs, we investigated the distribution and cumulative proportions of individuals with antibodies (Abs) to the SARS-CoV-2 nucleocapsid antigen (Ag), in the period from June to December 2020, using a three-phase monitoring process. In addition, during the formation of the cohort of volunteers, the number of seropositive convalescents, persons who had contact with patients or COVID-19 convalescents, and the prevalence of asymptomatic forms of infection among seropositive volunteers were determined. According to a uniform methodology, 3 mL of blood was taken from the examined individuals, and plasma was separated, from which the presence of Abs to nucleocapsid Ag was determined on a Thermo Scientific Multiascan FC device using the “ELISA anti-SARS-CoV-2 IgG” reagent set (prod. Scientific Center for Applied Microbiology and Biotechnology), in accordance with the developer’s instructions. Volunteers (74,158) were surveyed and divided into seven age groups (1–17, 18–29, 30–39, 40–49, 59–59, 60–69, and 70+ years old), among whom 14,275 were identified as having antibodies to SARS-CoV-2. The average percent seropositive in Russia was 17.8% (IQR: 8.8–23.2). The largest proportion was found among children under 17 years old (21.6% (IQR: 13.1–31.7). In the remaining groups, seroprevalence ranged from 15.6% (IQR: 8–21.1) to 18.0% (IQR: 13.4–22.6). During monitoring, three (immune) response groups were found: (A) groups with a continuous increase in the proportion of seropositive; (B) those with a slow rate of increase in seroprevalence; and (C) those with a two-phase curve, wherein the initial increase was replaced by a decrease in the percentage of seropositive individuals. A significant correlation was revealed between the number of COVID-19 convalescents and contact persons, and between the number of contacts and healthy seropositive volunteers. Among the seropositive volunteers, more than 93.6% (IQR: 87.1–94.9) were asymptomatic. The results show that the COVID-19 pandemic is accompanied by an increase in seroprevalence, which may be important for the formation of herd immunity.

In the article, the authors propose the conceptual fundamentals of the “code approach” to the regional neo-industrial development. The purpose of the research is to reveal the essence of the transition to a new type of industrial and economic relations through a prism of “genetic codes” of the region. We consider these codes as a system of the “racial memory” of a territory, which determines the specificity and features of neo-industrialization realization. We substantiated the hypothesis about the influence of the “genetic codes” of the region on the effectiveness of the neo-industrialization. We have defined the participants, or else the carriers of the codes in the transformation of regional inheritance for the stimulation of the neoindustrial development of region’s economy. The subject matter of the research is the distinctive features of the functioning of the determinative region’s codes. Their content determines the socio-economic specificity of the region and the features of innovative, informational, value-based and competence-based development of the territory. The determinative codes generate the dynamic codes of the region, which are understood as their derivatives. They have a high probability of occurrence, higher speed of development and distribution, internal forces that make possible the self-development of the region. The scientific contribution is the substantiation of the basic code of the regional neo-industrial development. It represents the evolutionary accumulation of the rapid changes of its innovative, informational, value-based and competence-based codes stimulating the generation and implementation of new ideas regarding to economic entities adapted to the historical and cultural conditions. The article presents the code model of neo-industrial development of the region described by formulas. We applied the system analysis methods, historical and civilization approaches, evolutionary and institutional theory, economic and mathematical methods. Moreover, in the article, the authors presented the findings for the period 2011–2016 reflecting the empirical estimation of the importance of informational, institutional, innovative, value-based and competence-based codes. We made this estimation through the survey of population, representatives of business and authorities, students, as well as the professors of the leading universities of the Ural Federal District. The focus of the recommendations for the region is the acceleration of the transition to the new type of industrial development. The research results can be used when developing the programmes and projects of neo- and reindustrialization at both federal and regional levels.

Development of the Research School Road in SibADI associated with the name of Mogilevich VM Scientist, teacher, organizer - these qualities helped him to raise the development of science, not only in the department "Construction and operation of roads," but in general at the university. His case was continued to his disciples. At the Faculty of "Roads and bridges" continues the school of scientific personnel.

The article substantiates the impact of the institutional factor on the development of regional international economic relations. The scope of the study is regional international economic activity (IEA), the subject-matter is the role of the institutional factor in its development. The study purpose is to develop a scientific approach for the assessment of the institutional factor impact on the development of region’s international economic relations. The hypothesis is that the targeted efforts of all participants of IEA of the region (business, authorities, local community) to strengthen of theese components of the institutional factor, which have a strong influence on the regional socio-economic development. A methodological approach for the assessment of this influenceis developed. It includes determining three elements of IEA institutionalization—agreements, organizations, events. A three-dimensional model is proposed for the coordination of these elements with 3 groups of countries—developed, developing and CIS, including the Eurasian Economic Union, and also with basic indexes characterizing the qualitative and quantitative contribution of region’s IEA into its socio-economic development. This model is tested on the example of the Sverdlovsk region of Russia for 2003–2015. That has allowed to define various kinds of the effects from strenthening the IEA institutional component, which are expressed in the increase of the export of the region, improvement of its investment attractiveness, the diversification of regional economy as well as the the generation of additional jobs and tax flows increase.

This article presents the findings of the study on the role of innovative entrepreneurship in the regional economy. The analysis is based on the methodology developed by Hermann Simon, a German scientist who has coined the term ”hidden champions” describing the phenomenon of little-known successful companies that act as innovative growth engines in the German economy. Today, the economies in different countries are developing amid the ”new normal,” in which no expected recovery followed the global crisis of 2008. This makes it necessary to rethink the role of entrepreneurship during a prolonged recession. The authors proposed and tested the hypothesis that, in this environment, the economic growth in the country and the region is increasingly determined not so much by large businesses, but by many small innovative companies. To identify Russian ”hidden champions,” we studied more than 1247 companies listed in the Innovation and Investment Market, a specialized section of the Moscow Exchange, and included in the specialized Register of Business Entities that use nanotechnology. We identified specifically Russian features of innovative entrepreneurship related to national cultural and historical characteristics and the current policy of import substitution. The authors proposed their own method for assessing the innovative entrepreneurship as a source of economic growth in the Russian regions that defines five groups of innovative entrepreneurs (global market leader, one of the global market leaders, Russian market leader, one of the Russian market leaders, not the leader in the Russian market) and compares them with large companies in terms of turnover and profit dynamics. Based on such criteria as ”number of ”hidden champions” and ”number of large enterprises per 100 thousand organizations,” we built a model for the ratio of ”hidden champions” to major companies in the Russian regions that identifies, for each criterion, three subgroups, including leaders, medium-tier and outsiders, which allowed to identify nine types of Russian regions and substantiate different development strategies for main types of regions. The study confirms that the most justified strategy for the development of innovative entrepreneurship in the region is the strategy of cooperation between different types of companies in order to overcome their weaknesses, enhance existing opportunities and activate the innovation and entrepreneurial capacity.

Цель. Статья посвящена актуальной в условиях современной образовательной парадигмы теме родительско-детских отношений. Автор ставит целью выявить взаимосвязи между особенностями семейного воспитания и спецификой межличностного взаимодействия дошкольников с интеллектуальной недостаточностью. Методы исследования (классификация Б.Г. Ананьева): психодиагностические (анкетирование, метод экспертных оценок, проективный метод, беседа), праксиметрические (анализ продуктов деятельности), методы обработки экспериментальных данных (количественный и качественный анализ), методы интерпретации данных (структурный анализ). Результаты. Результаты работы заключаются в том, что автор выявляет корреляцию между особенностями общения в системе «родители-ребенок» и характеристиками межличностного взаимодействия со сверстниками (стремление к взаимодействию со взрослыми и сверстниками, позиция в группе сверстников, предпочтения в выборе партнеров по общению, использование вербальных и невербальных средств общения). Автор делает предположение, что выявленные взаимосвязи можно использовать для повышения эффективности программы психокоррекционной работы, направленной на развитие межличностного взаимодействия со сверстниками дошкольников с интеллектуальной недостаточностью. Область применения результатов. Результаты исследования могут быть применены в сфере образования.

We present a case of a teenage boy with a Rabson-Mendenhall syndrome. There are only few recent publications on the topic of Rabson-Mendenhall syndrome in medical literature. This syndrome appears with a same frequency in both sexes. The disease prevalence is still unknown due to many undiagnosed cases linked with high mortality in early childhood. There are no prenatal screening for this disease till now, but it is clear, that in case of positive diagnostic tests, abortion should be recommended. The typical clinical symptoms of Rabson-Mendenhall syndrome are the following: physical development delay, loss of subcutaneous fat, teeth and nails abnormalities (premature teeth eruption, teeth number doubling, nails thickening). The earliest signs of the syndrome are skin hyperpigmentation and hyperkeratosis at neck, armpits and groin, which are typical for insulin resistance. Children with Rabson-Mendenhall syndrome usually have early manifestation of diabetes mellitus, characterized by labile disease course and frequent ketoacidosis state. The present clinical case might be interesting regarding a long follow-up of the child.

The article considers national economic interests that form the basis of national security (food, raw materials, finance, infrastructure including transport) and set the priorities for the development of economic sectors (industry, scientific and technological development, entrepreneurship, social sector and innovation development). The authors carry out brief analysis for each type of national economic interests and find out how they are reflected in the national documents on socio-economic development and in international documents on economic cooperation with Russia’s participation. These interests in the national aspect are reflected in the Concept for long-term socio-economic development, and in the strategies and state programs for development of economic sectors. As for the international economic aspect, the authors consider Russia’s contracts with individual countries on trade and/or cooperation, the Agreement on the Eurasian Economic Union, the Declaration and agreements of the BRICS countries, the Program for Trade and Economic cooperation between the SCO countries, and international standards relating to socio-economic ratings and indexes. The analysis shows that the country requires the development of a unified conceptual project that would link strategic priorities of socio-economic development of the Russian Federation with changing geoeconomic conditions. This independent project should represent a set of system strategic guidelines on different levels, enhancing the role and increasing the importance of Russia in the new architecture of the geo-economic world order, the country’s participation in the joint strategies implemented by the Russian Federation together with other interested countries and new integration groups, and also defending conceptual interests of national development

The ability of mesenchymal stromal (stem) cells (MSCs) to be mobilised from their local depot towards sites of injury and to participate in tissue repair makes these cells promising candidates for cell therapy. Physiological O2 tension in an MSC niche in vivo is about 4–7%. However, most in vitro studies of MSC functional activity are performed at 20% O2. Therefore, this study focused on the effects of short-term hypoxic stress (0.1% O2, 24 h) on adipose tissue-derived MSC motility at tissue-related O2 level. No significant changes in integrin expression were detected after short-term hypoxic stress. However, O2 deprivation provoked vimentin disassembly and actin polymerisation and increased cell stiffness. In addition, hypoxic stress induced the downregulation of ACTR3, DSTN, MACF1, MID1, MYPT1, NCK1, ROCK1, TIAM1, and WASF1 expression, the products of which are known to be involved in leading edge formation and cell translocation. These changes were accompanied by the attenuation of targeted and nontargeted migration of MSCs after short-term hypoxic exposure, as demonstrated in scratch and transwell migration assays. These results indicate that acute hypoxic stress can modulate MSC function in their native milieu, preventing their mobilisation from sites of injury.

Human adipose tissue-stromal derived cells (ASCs) are considered a perspective tool for regenerative medicine. Depending on the application mode ASC/allogeneic immune cell interaction can occur in the systemic circulation under plenty high concentrations of O2 and in target tissues at lower O2 levels. Here we examined the effects of allogeneic PHA-stimulated peripheral blood mononuclear cells (PBMCs) on ASCs under ambient (20%) oxygen and “physiological” hypoxia (5% O2). As revealed with microarray analysis ASCs under 20% O2 were more affected by activated PBMCs, which was manifested in differential expression of more than 300 genes, whereas under 5% O2 only 140 genes were changed. Altered gene pattern was only partly overlapped at different O2 conditions. Under O2 ASCs retained their proliferative and differentiative capacities, mesenchymal phenotype, and intracellular organelle’ state. ASCs were proinflammatory activated on transcription level that was confirmed by their ability to suppress activation and proliferation of mitogen-stimulated PBMCs. ASC/PBMCs interaction resulted in anti-inflammatory shift of paracrine mediators in conditioning medium with significant increase of immunosuppressive LIF level. Our data indicated that under both ambient and tissue-related O2 ASCs possessed immunosuppressive potential and maintained functional activity. Under “physiological” hypoxia ASCs were less susceptible to “priming” by allogeneic mitogen-activated PBMCs.

In the submitted work, important factors for planning out experiments for studying nutritional indices, whose choice may affect research results, and opportunities for using the indices of feeding to study the ecology of species are evaluated.The dependence of nutritional indices on great many factors and significant variation in their absolute values over different years make possible their research only as part of a complex issue togetherwith population factors and external conditions. A careful comparison of results from different studies is made.

Type 1 diabetes mellitus (DM1) exerts negative impact on the formation and functioning of the reproductive system in young girls. The time of onset(especially in the prepubertal period) and duration of DM1 as well as the lack of metabolic control may cause delay of puberty, affect the age of menarche,and increase the frequency of menstrual disturbances (largely in the form oligo- and amenorrhoea). Despite extensive research devoted to thisproblem, the main cause of reproductive dysfunction in such patients remains unclear even though DM1 is known to negatively affect performanceof the hypothalamo-pituitary axis. Pathogenetic mechanisms behind reproductive disturbances include suppression of GnRH pulses due to enhancedcentral dopamine and opiate activity, decreased expression of insulin receptors on neural cells, and altered plasma leptin level. Pituitary may be affectedboth by hypothalamic activity and by lipid free radical oxidation products decreasing production of tropic hormones (LH and FSH).

Data on the worldwide prevalence of carbohydrate metabolism disturbances are reviewed. Pathogenesis of metabolic syndrome in menopausal women(menopausal metabolic syndrome) is considered, its clinical and laboratory characteristics are presented. Main therapeutic modalities (medicamenousand non-medicamentous) are discussed. Properties of the hypoglycemic drug metformin and indications to its use are described along with indicationsand contraindications to substitution hormonal therapy in women with metabolic disturbances

The optimisation of haematopoietic stem and progenitor cell expansion is on demand in modern cell therapy. In this work, haematopoietic stem/progenitor cells (HSPCs) have been selected from unmanipulated cord blood mononuclear cells (cbMNCs) due to adhesion to human adipose-tissue derived stromal cells (ASCs) under standard (20%) and tissue-related (5%) oxygen. ASCs efficiently maintained viability and supported further HSPC expansion at 20% and 5% O2. During co-culture with ASCs, a new floating population of differently committed HSPCs (HSPCs-1) grew. This suspension was enriched with СD34+ cells up to 6 (20% O2) and 8 (5% O2) times. Functional analysis of HSPCs-1 revealed cobble-stone area forming cells (CAFCs) and lineage-restricted colony-forming cells (CFCs). The number of CFCs was 1.6 times higher at tissue-related O2, than in standard cultivation (20% O2). This increase was related to a rise in the number of multipotent precursors - BFU-E, CFU-GEMM and CFU-GM. These changes were at least partly ensured by the increased concentration of MCP-1 and IL-8 at 5% O2. In summary, our data demonstrated that human ASCs enables the selection of functionally active HSPCs from unfractionated cbMNCs, the further expansion of which without exogenous cytokines provides enrichment with CD34+ cells. ASCs efficiently support the viability and proliferation of cord blood haematopoietic progenitors of different commitment at standard and tissue-related O2 levels at the expense of direct and paracrine cell-to-cell interactions.