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1,021 results on '"Dulac, Olivier"'

301. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy

Author

Barcia, Giulia, primary, Fleming, Matthew R, additional, Deligniere, Aline, additional, Gazula, Valeswara-Rao, additional, Brown, Maile R, additional, Langouet, Maeva, additional, Chen, Haijun, additional, Kronengold, Jack, additional, Abhyankar, Avinash, additional, Cilio, Roberta, additional, Nitschke, Patrick, additional, Kaminska, Anna, additional, Boddaert, Nathalie, additional, Casanova, Jean-Laurent, additional, Desguerre, Isabelle, additional, Munnich, Arnold, additional, Dulac, Olivier, additional, Kaczmarek, Leonard K, additional, Colleaux, Laurence, additional, and Nabbout, Rima, additional

Published
2012
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304. Efficacy and tolerability of the new antiepileptic drugs : commentary on the recently published practice parameters.

Author

Panayiotopoulos, Chrystostomos P, Benbadis, Selim R, Covanis, Anthanasios, Dulac, Olivier, Duncan, John S, Eeg-Olofsson, Orvar, Ferrie, Colin D, Grunewald, Richard A, Kasteleijn-Nolst Trenite, Dorothee G A, Koutroumanidis, Michael, Martinovic, Zarko, Newton, Richard W, Parker, Alasdair P, Salas-Puig, Janvier, Sander, J W A S, Shorvon, Simon, Watanabe, Kazuyoshi, Whitehouse, William P, Youroukos, Sotirios, Panayiotopoulos, Chrystostomos P, Benbadis, Selim R, Covanis, Anthanasios, Dulac, Olivier, Duncan, John S, Eeg-Olofsson, Orvar, Ferrie, Colin D, Grunewald, Richard A, Kasteleijn-Nolst Trenite, Dorothee G A, Koutroumanidis, Michael, Martinovic, Zarko, Newton, Richard W, Parker, Alasdair P, Salas-Puig, Janvier, Sander, J W A S, Shorvon, Simon, Watanabe, Kazuyoshi, Whitehouse, William P, and Youroukos, Sotirios

Published
2004

305. Regional cerebral glucose metabolism in epilepsies with continuous spikes and waves during sleep.

Author

De Tiege, Xavier, Goldman, Serge, Laureys, S., Verheulpen, Denis, Chiron, Christelle, Wetzburger, Catherine, Paquier, Philippe, Chaigne, D, Poznanski, Nathalie, Jambaqué, I, Hirsch, E, Dulac, Olivier, Van Bogaert, Patrick, De Tiege, Xavier, Goldman, Serge, Laureys, S., Verheulpen, Denis, Chiron, Christelle, Wetzburger, Catherine, Paquier, Philippe, Chaigne, D, Poznanski, Nathalie, Jambaqué, I, Hirsch, E, Dulac, Olivier, and Van Bogaert, Patrick

Abstract

BACKGROUND: Epileptic syndromes with continuous spikes and waves during sleep (CSWS) represent a wide spectrum of epileptic conditions associated with cognitive dysfunctions that have the EEG pattern of CSWS as a common feature. Reported are the results of voxel-based analyses of brain glucose metabolism performed in a group of 18 children with CSWS. METHODS: Voxel-based analyses of cerebral glucose metabolism were performed using statistical parametric mapping (SPM). First, each patient was compared with a control group and the influence of age, epileptic activity, and corticosteroid treatment on metabolic abnormalities was studied. Also, disease-related changes in the contribution of a brain area to the level of metabolic activity in another brain area were investigated using pathophysiologic interactions in groups of patients compared with the control group. RESULTS: Individual SPM analyses identified three metabolic patterns: association of hypermetabolic and hypometabolic areas, hypometabolic areas only, and normal pattern. Age and intensity of awake interictal spiking did not significantly differ in patients showing focal hypermetabolism compared with the other ones. Treatment with corticosteroids was associated with absence of focal hypermetabolism. In the group of patients with hypermetabolic areas, analyses of pathophysiologic interactions showed disease-related altered functional connectivity between the parietal and frontal cortices. CONCLUSIONS: Cerebral metabolic patterns are heterogeneous among patients with CSWS. This metabolic heterogeneity could be related to the use of corticosteroid treatment before PET. The parietofrontal altered connectivity observed in patients with hypermetabolism is interpreted as a phenomenon of remote inhibition of the frontal lobes induced by highly epileptogenic and hypermetabolic posterior cortex., Journal Article, Research Support, Non-U.S. Gov't, info:eu-repo/semantics/published

Published
2004

307. Lafora progressive myoclonus epilepsy: NHLRC1 mutations affect glycogen metabolism

Author

Couarch, Philippe, primary, Vernia, Santiago, additional, Gourfinkel-An, Isabelle, additional, Lesca, Gaëtan, additional, Gataullina, Svetlana, additional, Fedirko, Estelle, additional, Trouillard, Oriane, additional, Depienne, Christel, additional, Dulac, Olivier, additional, Steschenko, Dominique, additional, Leguern, Eric, additional, Sanz, Pascual, additional, and Baulac, Stéphanie, additional

Published
2011
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309. Evidences for parieto-frontal dysconnection in epileptic syndromes with continuous spikes and waves during slow sleep

Author

De Tiege, Xavier, Goldman, Serge, Laureys, Steven, Verheulpen, Denis, Chiron, Christelle, Dulac, Olivier, Van Bogaert, Patrick, De Tiege, Xavier, Goldman, Serge, Laureys, Steven, Verheulpen, Denis, Chiron, Christelle, Dulac, Olivier, and Van Bogaert, Patrick

Abstract

A 07. Cet abstract a reçu un Young Investigator Travel Award, info:eu-repo/semantics/published

Published
2003

312. Neuropsychology of childhood epilepsy

Author

Jambaque, Isabelle., Lassonde, Maryse., Dulac, Olivier, 1946, Jambaque, Isabelle., Lassonde, Maryse., and Dulac, Olivier, 1946

Published
2002

314. Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14

Author

Chioza, Barry A., primary, Aicardi, Jean, additional, Aschauer, Harald, additional, Brouwer, Oebele, additional, Callenbach, Petra, additional, Covanis, Athanasios, additional, Dooley, Joseph M., additional, Dulac, Olivier, additional, Durner, Martina, additional, Eeg-Olofsson, Orvar, additional, Feucht, Martha, additional, Friis, Mogens Laue, additional, Guerrini, Renzo, additional, Kjeldsen, Marianne Juel, additional, Nabbout, Rima, additional, Nashef, Lina, additional, Sander, Thomas, additional, Sirén, Auli, additional, Wirrell, Elaine, additional, McKeigue, Paul, additional, Robinson, Robert, additional, Gardiner, R. Mark, additional, and Everett, Kate V., additional

Published
2009
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315. CDKL5 and ARX mutations are not responsible for early onset severe myoclonic epilepsy in infancy

Author

Nabbout, Rima, primary, Depienne, Christel, additional, Chipaux, Mathilde, additional, Girard, Benoit, additional, Souville, Isabelle, additional, Trouillard, Oriane, additional, Dulac, Olivier, additional, Chelly, Jamel, additional, Afenjar, Alexandra, additional, Héron, Delphine, additional, Leguern, Eric, additional, Beldjord, Cherif, additional, Bienvenu, Thierry, additional, and Bahi-Buisson, Nadia, additional

Published
2009
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316. Management of West Syndrome in a Patient With Methylmalonic Aciduria

Author

Campeau, Philippe M., primary, Valayannopoulos, Vassili, additional, Touati, Guy, additional, Bahi-Buisson, Nadia, additional, Boddaert, Nathalie, additional, Plouin, Perrine, additional, Rabier, Daniel, additional, Benoist, Jean-François, additional, Dulac, Olivier, additional, de Lonlay, Pascale, additional, and Desguerre, Isabelle, additional

Published
2009
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317. Inhibitory actions of the gamma-aminobutyric acid in pediatric Sturge-Weber syndrome

Author

Tyzio, Roman, primary, Khalilov, Ilgam, additional, Represa, Alfonso, additional, Crepel, Valerie, additional, Zilberter, Yuri, additional, Rheims, Sylvain, additional, Aniksztejn, Laurent, additional, Cossart, Rosa, additional, Nardou, Romain, additional, Mukhtarov, Marat, additional, Minlebaev, Marat, additional, Epsztein, Jérôme, additional, Milh, Mathieu, additional, Becq, Helene, additional, Jorquera, Isabel, additional, Bulteau, Christine, additional, Fohlen, Martine, additional, Oliver, Viviana, additional, Dulac, Olivier, additional, Dorfmüller, Georg, additional, Delalande, Olivier, additional, Ben-Ari, Yehezkel, additional, and Khazipov, Roustem, additional

Published
2009
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319. SCN1Aduplications and deletions detected in Dravet syndrome: Implications for molecular diagnosis

Author

Marini, Carla, primary, Scheffer, Ingrid E., additional, Nabbout, Rima, additional, Mei, Davide, additional, Cox, Kathy, additional, Dibbens, Leanne M., additional, McMahon, Jacinta M., additional, Iona, Xenia, additional, Carpintero, Rochio Sanchez, additional, Elia, Maurizio, additional, Cilio, Maria Roberta, additional, Specchio, Nicola, additional, Giordano, Lucio, additional, Striano, Pasquale, additional, Gennaro, Elena, additional, Cross, J. Helen, additional, Kivity, Sara, additional, Neufeld, Miriam Y., additional, Afawi, Zaid, additional, Andermann, Eva, additional, Keene, Daniel, additional, Dulac, Olivier, additional, Zara, Federico, additional, Berkovic, Samuel F., additional, Guerrini, Renzo, additional, and Mulley, John C., additional

Published
2009
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322. Taurine deficiency is a cause of vigabatrin-induced retinal phototoxicity

Author

Jammoul, Firas, primary, Wang, Qingping, additional, Nabbout, Rima, additional, Coriat, Caroline, additional, Duboc, Agnès, additional, Simonutti, Manuel, additional, Dubus, Elisabeth, additional, Craft, Cheryl M., additional, Ye, Wen, additional, Collins, Stephen D., additional, Dulac, Olivier, additional, Chiron, Catherine, additional, Sahel, José A., additional, and Picaud, Serge, additional

Published
2009
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329. Erratum: Linkage and association analysis of CACNG3 in childhood absence epilepsy

Author

Everett, Kate, primary, Chioza, Barry, additional, Aicardi, Jean, additional, Aschauer, Harald, additional, Brouwer, Oebele, additional, Callenbach, Petra, additional, Covanis, Athanasios, additional, Dulac, Olivier, additional, Eeg-Olofsson, Orvar, additional, Feucht, Martha, additional, Friis, Mogens, additional, Goutieres, Françoise, additional, Guerrini, Renzo, additional, Heils, Armin, additional, Kjeldsen, Marianne, additional, Lehesjoki, Anna-Elina, additional, Makoff, Andrew, additional, Nabbout, Rima, additional, Olsson, Ingrid, additional, Sander, Thomas, additional, Sirén, Auli, additional, McKeigue, Paul, additional, Robinson, Robert, additional, Taske, Nichole, additional, Rees, Michele, additional, and Gardiner, Mark, additional

Published
2008
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333. Linkage and mutational analysis of CLCN2 in childhood absence epilepsy

Author

Everett, Kate, primary, Chioza, Barry, additional, Aicardi, Jean, additional, Aschauer, Harald, additional, Brouwer, Oebele, additional, Callenbach, Petra, additional, Covanis, Athanasios, additional, Dooley, Joseph, additional, Dulac, Olivier, additional, Durner, Martina, additional, Eeg-Olofsson, Orvar, additional, Feucht, Martha, additional, Friis, Mogens, additional, Guerrini, Renzo, additional, Heils, Armin, additional, Kjeldsen, Marianne, additional, Nabbout, Rima, additional, Sander, Thomas, additional, Wirrell, Elaine, additional, McKeigue, Paul, additional, Robinson, Robert, additional, Taske, Nichole, additional, and Gardiner, Mark, additional

Published
2007
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336. Linkage and association analysis of CACNG3 in childhood absence epilepsy

Author

Everett, Kate V, primary, Chioza, Barry, additional, Aicardi, Jean, additional, Aschauer, Harald, additional, Brouwer, Oebele, additional, Callenbach, Petra, additional, Covanis, Athanasios, additional, Dulac, Olivier, additional, Eeg-Olofsson, Orvar, additional, Feucht, Martha, additional, Friis, Mogens, additional, Goutieres, Françoise, additional, Guerrini, Renzo, additional, Heils, Armin, additional, Kjeldsen, Marianne, additional, Lehesjoki, Anna-Elina, additional, Makoff, Andrew, additional, Nabbout, Rima, additional, Olsson, Ingrid, additional, Sander, Thomas, additional, Sirén, Auli, additional, McKeigue, Paul, additional, Robinson, Robert, additional, Taske, Nichole, additional, Rees, Michele, additional, and Gardiner, Mark, additional

Published
2007
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337. Pharmacokinetics of Clobazam and N-Desmethylclobazam in Children with Dravet Syndrome Receiving Concomitant Stiripentol and Valproic Acid.

Author

Jullien, Vincent, Chhun, Stéphanie, Rey, Elisabeth, Dulac, Olivier, Tod, Michel, Chiron, Catherine, and Pons, Gérard

Subjects
PHARMACOKINETICS, VALPROIC acid, DRUG dosage, CHILDHOOD epilepsy, BLOOD sampling, DRUG monitoring
Abstract

Aim: The aim of this study was to describe the pharmacokinetics of clobazam and its active metabolite N-desmethylclobazam (N-CLB) in children with Dravet syndrome receiving the stiripentol/valproic acid/clobazam combination therapy of reference and to determine the concentrations of clobazam and N-CLB obtained in this population for the usual 0.2 mg/kg twice-daily dose. Methods: Thirty-five children with epilepsy were included in a prospective population pharmacokinetic study (using NONMEM software). Four blood samples were drawn per patient. Area under the plasma concentration-time curve (AUC) and trough concentration ( C) values for clobazam and N-CLB were simulated for 12,000 theoretical children weighing between 10 and 60 kg. Results: The pharmacokinetics of clobazam were described by a one-compartment model with first-order absorption, and elimination, formation and elimination of N-CLB were also first-order processes. The apparent total clearance (CL/ F) and distribution volume ( V/ F) of clobazam and the elimination rate constant of N-CLB (Kem) were related to body weight by allometric equations. Mean population estimates (% inter-individual variability) were 1.23 L/h (29 %) for CL/ F, 39.1 L (18 %) for V/ F and 0.0706 h (26 %) for Kem. The AUC values for clobazam and N-CLB were found to increase by 100 % when bodyweight increased from 10 to 60 kg, and the simulated C values were higher than the currently accepted target values (0.03-0.3 mg/L for clobazam and 0.3-3 mg/L for N-CLB). Conclusion: This is the first simultaneous pharmacokinetic model for clobazam and N-CLB in epileptic children. Indicative values for the routine therapeutic drug monitoring of clobazam in children with Dravet syndrome treated by stiripentol are provided. The possible consequences of the weight-related changes on clobazam and N-CLB exposures should be further evaluated. [ABSTRACT FROM AUTHOR]

Published
2015
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338. Seizures and epilepsy in hypoglycaemia caused by inborn errors of metabolism.

Author

Gataullina, Svetlana, Delonlay, Pascale, Lemaire, Eric, Boddaert, Nathalie, Bulteau, Christine, Soufflet, Christine, Laín, Gemma Aznar, Nabbout, Rima, Chiron, Catherine, and Dulac, Olivier

Subjects
HYPOGLYCEMIA in children, INFANTILE spasms, CHILDHOOD epilepsy, METABOLIC disorders in children, GENETIC disorders in children, DISEASE risk factors
Abstract

Aim The aim of the study was to characterize seizures and epilepsy related to hypoglycaemia. Method We analyzed the files of 170 consecutive patients referred for hypoglycaemia (onset 1h to 4y) caused by inborn errors of metabolism (glycogen storage disease type I, fatty acid β-oxidation disorders, and hyperinsulinism). Results Ninety patients (42 males and 48 females; 38 neonates and 52 infants/children) had brief hypoglycaemic seizures (68%) or status epilepticus (32%). Status epilepticus occurred earlier (mean 1.4d) than brief neonatal seizures (4.3d, p=0.02). Recurrent status epilepticus followed initial status epilepticus and was often triggered by fever. Epilepsy developed in 21 patients. In 18 patients, epilepsy followed hypoglycaemic status epilepticus and began with shorter delay when associated with grey matter lesions (1.9mo, standard error of the mean [ SEM] 1mo) than with white matter damage (3.3y [ SEM 1y], p=0.003). Three patients with hyperinsulinism developed idiopathic epilepsy following brief neonatal seizures. Interpretation Brief neonatal hyperinsulinaemic hypoglycaemic seizures have characteristics of idiopathic neonatal seizures. Neonatal status epilepticus should be prevented by the systematic measurement of glucose blood level. Recurrent seizures never consist of status epilepticus when following brief initial seizures. Epilepsy is symptomatic of brain damage with shorter delay in the case of grey rather than white matter lesions, except in a few idiopathic cases in which epilepsy and hyperinsulinism may share a common genetic background. [ABSTRACT FROM AUTHOR]

Published
2015
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339. Herpes Simplex Virus Encephalitis in Human UNC-93B Deficiency

Author

Casrouge, Armanda, primary, Zhang, Shen-Ying, additional, Eidenschenk, Céline, additional, Jouanguy, Emmanuelle, additional, Puel, Anne, additional, Yang, Kun, additional, Alcais, Alexandre, additional, Picard, Capucine, additional, Mahfoufi, Nora, additional, Nicolas, Nathalie, additional, Lorenzo, Lazaro, additional, Plancoulaine, Sabine, additional, Sénéchal, Brigitte, additional, Geissmann, Frédéric, additional, Tabeta, Koichi, additional, Hoebe, Kasper, additional, Du, Xin, additional, Miller, Richard L., additional, Héron, Bénédicte, additional, Mignot, Cyril, additional, de Villemeur, Thierry Billette, additional, Lebon, Pierre, additional, Dulac, Olivier, additional, Rozenberg, Flore, additional, Beutler, Bruce, additional, Tardieu, Marc, additional, Abel, Laurent, additional, and Casanova, Jean-Laurent, additional

Published
2006
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341. Debate on the classification of epileptic seizures and syndromes: Are epilepsy classifications based on epileptic syndromes and seizure types outdated?; Letter to the Editor

Author

Engel, Jerome, primary, Berg, Anne, additional, Andermann, Frederick, additional, Avanzini, Giuliano, additional, Berkovic, Samuel, additional, Blume, Warren, additional, Dulac, Olivier, additional, van Emde Boas, Walter, additional, Fejerman, Natalio, additional, Plouin, Perrine, additional, Scheffer, Ingrid, additional, Seino, Masakazu, additional, Williamson, Peter, additional, and Wolf, Peter, additional

Published
2006
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