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Anxiety disorders frequently occur in individuals with neurologic illness. Anxiety may be a symptom of or a reaction to the neurologic disorder, a medication side effect, or a comorbid condition. The most common anxiety disorders seen in neurologic patients are panic disorder, generalized anxiety disorder, social phobia, and obsessive-compulsive disorder (OCD). Very often, these conditions go unrecognized (and therefore untreated) or are attributed to being a normal response to having a neurologic illness. However, if they are not treated, anxiety disorders can significantly increase morbidity and mortality in neurologic patients. Selective serotonin reuptake inhibitors (SSRIs) should be considered the first-line of pharmacologic treatment, because they offer a broad spectrum of efficacy in the anxiety disorders, are generally well tolerated, and are effective in treating comorbid depression. Benzodiazepines, although most effective for acute anxiety, are now considered adjunctive or second-line treatments. Cognitive behavioral therapy and other behavioral treatments are effective in the treatment of anxiety disorders. They should be considered primary treatments for patients who cannot tolerate or prefer not to take medications.

As primary care physicians become more comfortable prescribing treatments for anxiety disorders, mental health specialists increasingly are encountering patients with refractory anxiety. In this article, the authors briefly review causes of treatment resistance and approaches to failure to respond to treatment of specific anxiety disorders.

Objectives: We hypothesized that the cell volume of ventricular myocytes isolated from hearts in volume-overload congestive failure would respond differently to hypothermic cardioplegia than would sham-operated cohorts., Methods: Adult rabbits underwent either valvotomy and aortic regurgitation-induced heart failure or sham surgery. Congestive failure was confirmed clinically and by means of echocardiography. Cell volumes of isolated myocytes were measured by digital video microscopy. After equilibration in 37 degrees C physiologic solution, cells were suprafused with 9 degrees C standard or low-Cl(-) St Thomas' Hospital solution followed by reperfusion in 37 degrees C physiologic solution., Results: Exposure to cold St Thomas' Hospital solution for 20 minutes caused sham myocytes to swell by 8% (n = 9); cell volumes fully recovered on normothermic reperfusion. In contrast, congestive failure myocytes (n = 9) maintained their cell volume in cold St Thomas' Hospital solution and during reperfusion. Lowering the [K(+)][Cl(-)] product of St Thomas' Hospital solution by partially replacing Cl(-) with an impermeant anion prevented cellular edema in the sham group (n = 8) but caused a 4% swelling in failure myocytes (n = 10) on reperfusion. Osmotically shrinking the failure cells (n = 9) converted their behavior to that of sham cells., Conclusions: In the absence of ischemia, congestive failure myocytes are less sensitive to cardioplegia-induced edema than sham cells. Low-Cl(-) cardioplegia, which prevents edema and protects the normal heart, induced swelling and may be detrimental in myopathic hearts. Differences in volume regulation in failure and sham myocytes may be due to activation of volume-sensitive channels that are turned off by osmotic shrinkage.

The recent discovery of dust-correlated diffuse microwave emission has prompted two rival explanations: free-free emission and spinning dust grains. We present new detections of this component at 10 and 15 GHz by the switched-beam Tenerife experiment. The data show a turnover in the spectrum and thereby support the spinning dust hypothesis. We also present a significant detection of synchrotron radiation at 10 GHz, which is useful for normalizing foreground contamination of cosmic microwave background experiments at high galactic latitudes.

Objectives: We tested the hypothesis that neonatal cells are more sensitive to cardioplegia-induced cell swelling than more mature cells and spontaneous swelling in the absence of ischemia can be prevented by cardioplegia with a physiologic KCl product., Methods: Cell volumes of isolated ventricular myocytes from neonatal (3-5 days), intermediate (10-13 days), and adult (>6 weeks) rabbits were measured by digital video microscopy. After equilibration in 37 degrees C physiologic solution, cells were suprafused with 37 degrees C or 9 degrees C St Thomas' Hospital solution (standard or low Cl(-)) or 9 degrees C physiologic solution followed by reperfusion with 37 degrees C physiologic solution., Results: Neonatal cells swelled 16.2% +/- 1.8% (P <.01) in 37 degrees C St Thomas' Hospital solution and recovered during reperfusion, whereas more mature cells maintained constant volume. In contrast, 9 degrees C St Thomas' Hospital solution caused significant age-dependent swelling (neonatal, 16.8% +/- 1.5%; intermediate, 8.6% +/- 2.1%; adult, 5.6% +/- 1.1%). In contrast to more mature cells, neonatal cells remained significantly edematous throughout reperfusion (8.1% +/- 1.5%). Swelling was not due to hypothermia because 9 degrees C physiologic solution did not affect volume. Lowering the KCl product of St Thomas' Hospital solution by partially replacing Cl(-) with an impermeant anion prevented cellular edema in all groups., Conclusion: In the absence of ischemia, neonatal cells were more sensitive to cardioplegia-induced cellular edema than more mature cells, and edema observed in all groups was avoided by decreasing the KCl product of St Thomas' Hospital solution to the physiologic range. Differences in cell volume regulation may explain the sensitivity of neonatal hearts to hyperkalemic cardioplegic arrest and suggest novel approaches to improving myocardial protection.

Objective: The aim of this ecological study was to examine the relationship between potential cyanobacterial exposure through drinking water during pregnancy and birth outcomes., Method: One hundred and fifty-six communities in South-Eastern Australia were involved, providing 32,700 singleton live newborn during the period 1992-94. Cyanobacterial occurrence and cell density (alert level) in drinking water sources during the first trimester, the total gestational period for premature births or limited to 36 weeks in term infants, and the last 12 weeks prior to preterm births or up to and including 36 weeks in term infants were used as estimates of exposure., Results: There were statistically significant differences between the proportion of time during the first trimester with cyanobacterial occurrence and the percentage of births that were low birth weight (LBW) and very low birth rate (VLBW). Significant differences were also found among various categories of first trimester exposure based on average cell density and LBW, prematurity and congenital defects. However, the pattern of these results does not suggest a causal link to cyanobacteria. There were no clear dose-response relationships. Analyses based on exposure during the last 12 weeks and total gestation also showed no significant dose-response effects., Conclusion: The results of this study provide no clear evidence for an association between cyanobacterial contamination of drinking water sources and adverse pregnancy outcomes.

A technique is described in which a ring of air is used to produce sample concentration by solvent evaporation on high-performance thin-layer chromatography plates. The technique is compared to the ring-oven technique and both are evaluated by using a dye mixture. Both techniques are employed to reduce the size of relatively large spots on the plates in an attempt to match the resolution obtained from small spots in circular chromatography.