251. Yersinia type III secretion: send in the effectors.
- Author
-
Cornelis GR
- Subjects
- Adhesins, Bacterial metabolism, Animals, Cell Surface Extensions immunology, Eukaryotic Cells cytology, Eukaryotic Cells metabolism, Humans, Inflammation immunology, Inflammation microbiology, Phagocytosis immunology, Yersinia pathogenicity, Yersinia Infections physiopathology, Adhesins, Bacterial immunology, Bodily Secretions microbiology, Cell Surface Extensions microbiology, Eukaryotic Cells microbiology, Protein Transport physiology, Yersinia metabolism, Yersinia Infections metabolism
- Abstract
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells' response to infection. Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis and inflammation.
- Published
- 2002
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