251. [Importance of hyaluronic acid in the modulation of neutrophil migration].
- Author
-
Mazzone A, Baiguera R, Casali G, Tarantola M, Rossini S, and Ricevuti G
- Subjects
- Adolescent, Aged, Cells, Cultured, Chemotactic Factors biosynthesis, Culture Media, Hematologic Diseases immunology, Humans, Middle Aged, Monocytes drug effects, Monocytes metabolism, Phagocytes drug effects, Phagocytosis drug effects, Skin Window Technique, Chemotaxis, Leukocyte drug effects, Hyaluronic Acid pharmacology, Neutrophils drug effects
- Abstract
The relationship between JA and phagocyte function has often been reported in the literature. The action of JA may either inhibit or stimulate PMNs function depending on the concentration. On the basis of this experience, the efficacy of JA action, both directly and mediated after incubation was studied. In particular phagocytosis, NBT, superoxide production and chemotaxis were studied in basal conditions and after incubation with hyaluronic acid. In particular chemotaxis was also performed to assay the chemotactic action of the medium in which the monocytes were incubated with JA and the technique was found to produce a distinct progressive improvement in the chemotactic index. In conclusion, it is hypothesised that monocytes incubated with JA produce a chemotactic factor for PMNs.
- Published
- 1986