151. Endocrine disrupting-chemicals and biochemical recurrence of prostate cancer after prostatectomy: A cohort study in Guadeloupe (French West Indies).
- Author
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Brureau L, Emeville E, Helissey C, Thome JP, Multigner L, and Blanchet P
- Subjects
- Aged, Chlordecone adverse effects, Chlordecone blood, Dichlorodiphenyl Dichloroethylene adverse effects, Dichlorodiphenyl Dichloroethylene blood, Disease-Free Survival, Environmental Pollutants blood, Follow-Up Studies, Guadeloupe, Humans, Insecticides adverse effects, Insecticides blood, Kallikreins blood, Male, Middle Aged, Neoplasm Recurrence, Local blood, Neoplasm Recurrence, Local etiology, Polychlorinated Biphenyls adverse effects, Polychlorinated Biphenyls blood, Prostate-Specific Antigen blood, Prostatic Neoplasms mortality, Prostatic Neoplasms surgery, Risk Factors, Endocrine Disruptors adverse effects, Environmental Pollutants adverse effects, Neoplasm Recurrence, Local epidemiology, Prostatectomy, Prostatic Neoplasms pathology
- Abstract
Previous studies have suggested that exposure to environmental chemicals with hormonal properties, also called endocrine disrupting chemicals, may be involved in the occurrence of prostate cancer (PCa). Such exposure may also influence the treatment outcome as it is still present at the time of diagnosis, the beginning of therapy, and beyond. We followed 326 men in Guadeloupe (French West Indies) who underwent radical prostatectomy as primary treatment of localized PCa. We analyzed the relationship between exposure to the estrogenic chlordecone, the antiandrogenic dichlorodiphenyldichloroethylene (DDE, the main metabolite of the insecticide DDT), and the nondioxin-like polychlorinated biphenyl congener 153 (PCB-153) with mixed estrogenic/antiestrogenic properties and the risk of biochemical recurrence (BCR) after surgery. After a median follow-up of 6.1 years after surgery, we found a significant increase in the risk of BCR, with increasing plasma chlordecone concentration (adjusted hazard ratio = 2.51; 95% confidence interval: 1.39-4.56 for the highest vs. lowest quartile of exposure; p trend = 0.002). We found no associations for DDE or PCB-135. These results shown that exposure to environmental estrogens may negatively influence the outcome of PCa treatment., (© 2019 UICC.)
- Published
- 2020
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