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We present a catalogue of nearly 3,000 submillimetre sources detected at 850um over ~5 square degrees surveyed as part of the James Clerk Maxwell Telescope (JCMT) SCUBA-2 Cosmology Legacy Survey (S2CLS). This is the largest survey of its kind at 850um, probing a meaningful cosmic volume at the peak of star formation activity and increasing the sample size of submillimetre galaxies selected at 850um by an order of magnitude. We describe the wide 850um survey component of S2CLS, which covers the key extragalactic survey fields: UKIDSS-UDS, COSMOS, Akari-NEP, Extended Groth Strip, Lockman Hole North, SSA22 and GOODS-North. The average 1-sigma depth of S2CLS is 1.2 mJy/beam, approaching the SCUBA-2 850um confusion limit, which we determine to be ~0.8 mJy/beam. We measure the single dish 850um number counts to unprecedented accuracy, reducing the Poisson errors on the differential counts to approximately 4% at S_850~3mJy. With several independent fields, we investigate field-to-field variance, finding that the number counts on 0.5-1 degree scales are generally within 50% of the S2CLS mean for S_850>3mJy, with scatter consistent with the Poisson and estimated cosmic variance uncertainties, although there is a marginal (2-sigma) density enhancement in the GOODS-North field. The observed number counts are in reasonable agreement with recent phenomenological and semi-analytic models. Finally, the large solid angle of S2CLS allows us to measure the bright-end counts: at S_850>10mJy there are approximately ten sources per square degree, and we detect the distinctive up-turn in the number counts indicative of the detection of local sources of 850um emission and strongly lensed high-redshift galaxies. Here we describe the data collection and reduction procedures and present calibrated maps and a catalogue of sources; these are made publicly available., Comment: Submitted to MNRAS, comments welcome. Catalogue and maps at http://dx.doi.org/10.5281/zenodo.57792

Hot, Dust-Obscured Galaxies (Hot DOGs), selected from the WISE all sky infrared survey, host some of the most powerful Active Galactic Nuclei (AGN) known, and might represent an important stage in the evolution of galaxies. Most known Hot DOGs are at $z> 1.5$, due in part to a strong bias against identifying them at lower redshift related to the selection criteria. We present a new selection method that identifies 153 Hot DOG candidates at $z\sim 1$, where they are significantly brighter and easier to study. We validate this approach by measuring a redshift $z=1.009$, and an SED similar to higher redshift Hot DOGs for one of these objects, WISE J1036+0449 ($L_{\rm\,Bol}\simeq 8\times 10^{46}\rm\,erg\,s^{-1}$), using data from Keck/LRIS and NIRSPEC, SDSS, and CSO. We find evidence of a broadened component in MgII, which, if due to the gravitational potential of the supermassive black hole, would imply a black hole mass of $M_{\rm\,BH}\simeq 2 \times 10^8 M_{\odot}$, and an Eddington ratio of $\lambda_{\rm\,Edd}\simeq 2.7$. WISE J1036+0449 is the first Hot DOG detected by NuSTAR, and the observations show that the source is heavily obscured, with a column density of $N_{\rm\,H}\simeq(2-15)\times10^{23}\rm\,cm^{-2}$. The source has an intrinsic 2-10 keV luminosity of $\sim 6\times 10^{44}\rm\,erg\,s^{-1}$, a value significantly lower than that expected from the mid-infrared/X-ray correlation. We also find that the other Hot DOGs observed by X-ray facilities show a similar deficiency of X-ray flux. We discuss the origin of the X-ray weakness and the absorption properties of Hot DOGs. Hot DOGs at $z\lesssim1$ could be excellent laboratories to probe the characteristics of the accretion flow and of the X-ray emitting plasma at extreme values of the Eddington ratio., Comment: Accepted for publication in ApJ, 16 pages

Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address s, Funding Agencies|Terry Fox Foundation Grant [TF-13-20]; UAEU Program for Advanced Research (UPAR) [31S118]; NIH [AR47901, R21CA188818, R15 CA137499-01, F32CA177139, P20RR016477, P20GM103434, R01CA170378, U54CA149145, U54CA143907, R01-HL107652, R01CA166348, R01GM071725, R01 CA109335-04A1, 109511R01CA151304CA168997 A11106131R03CA1711326 1P01AT003961RO1 CA100816P01AG034906 R01AG020642P01AG034906-01A1R01HL108006]; NIH NRSA Grant [F31CA154080]; NIH (NIAID) R01: Combination therapies for chronic HBV, liver disease, and cancer [AI076535]; Sky Foundation Inc. Michigan; University of Glasgow; Beatson Oncology Centre Fund; Spanish Ministry of Economy and Competitivity, ISCIII [PI12/00137, RTICC: RD12/0036/0028]; FEDER from Regional Development European Funds (European Union), Consejeria de Ciencia e Innovacion [CTS-6844, CTS-1848]; Consejeria de Salud of the Junta de Andalucia [PI-0135-2010, PI-0306-2012]; ISCIII [PIE13/0004]; FEDER funds; United Soybean Board; NIH NCCAM Grant [K01AT007324]; NIH NCI Grant [R33 CA161873-02]; Michael Cuccione Childhood Cancer Foundation Graduate Studentship; Ovarian and Prostate Cancer Research Trust, UK; West Virginia Higher Education Policy Commission/Division of Science Research; National Institutes of Health; Italian Association for Cancer Research (AIRC) [IG10636, 15403]; GRACE Charity, UK; Breast Cancer Campaign, UK; Michael Cuccione Childhood Cancer Foundation Postdoctoral Fellowship; Connecticut State University; Swedish Research Council; Swedish Research Society; University of Texas Health Science Centre at Tyler, Elsa U. Pardee Foundation; CPRIT; Cancer Prevention and Research Institute of Texas; NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); NIH National Institute on Alcohol Abuse and Alcoholism (NIAAA); Gilead and Shire Pharmaceuticals; NIH/NCI [1R01CA20009, 5R01CAl27258-05, R21CA184788, NIH P30 CA22453, NCI RO1 28704]; Scottish Governments Rural and Environment Science and Analytical Services Divis

Hot Dust-Obscured Galaxies (Hot DOGs) are a population of hyper-luminous infrared galaxies identified by the WISE mission from their very red mid-IR colors, and characterized by hot dust temperatures ($T>60~\rm K$). Several studies have shown clear evidence that the IR emission in these objects is powered by a highly dust-obscured AGN that shows close to Compton-thick absorption at X-ray wavelengths. Thanks to the high AGN obscuration, the host galaxy is easily observable, and has UV/optical colors usually consistent with those of a normal galaxy. Here we discuss a sub-population of 8 Hot DOGs that show enhanced rest-frame UV/optical emission. We discuss three scenarios that might explain the excess UV emission: (i) unobscured light leaked from the AGN by reflection over the dust or by partial coverage of the accretion disk; (ii) a second unobscured AGN in the system; or (iii) a luminous young starburst. X-ray observations can help discriminate between these scenarios. We study in detail the blue excess Hot DOG WISE J020446.13-050640.8, which was serendipitously observed by Chandra/ACIS-I for 174.5 ks. The X-ray spectrum is consistent with a single, hyper-luminous, highly absorbed AGN, and is strongly inconsistent with the presence of a secondary unobscured AGN. Based on this, we argue that the excess blue emission in this object is most likely either due to reflection or a co-eval starburst. We favor the reflection scenario as the unobscured star-formation rate needed to power the UV/optical emission would be $\gtrsim 1000~\rm M_{\odot}~\rm yr^{-1}$. Deep polarimetry observations could confirm the reflection hypothesis., Comment: 13 pages, 7 figures, 2 tables. Accepted for publication in The Astrophysical Journal

Observed at z = 4.601 and with L_bol = 3.5 x 10^14 Lsun, W2246-0526 is the most luminous galaxy known in the Universe, and hosts a deeply-buried active galactic nucleus (AGN)/super-massive black hole (SMBH). Discovered using the Wide-field Infrared Survey Explorer (WISE), W2246-0526 is classified as a Hot Dust Obscured Galaxy (Hot DOG), based on its luminosity and dust temperature. Here we present spatially resolved ALMA [CII]157.7um observations of W2246-0526, providing unique insight into the kinematics of its interstellar medium (ISM). The measured [CII]-to-far-infrared ratio is ~2 x 10^-4, implying ISM conditions that compare only with the most obscured, compact starbursts and AGN in the local Universe today. The spatially resolved [CII] line is strikingly uniform and very broad, 500-600 km/s wide, extending throughout the entire galaxy over about 2.5 kpc, with modest shear. Such a large, homogeneous velocity dispersion indicates a highly turbulent medium. W2246-0526 is unstable in terms of the energy and momentum that are being injected into the ISM, strongly suggesting that the gas is being blown away from the system isotropically, likely reflecting a cathartic state on its road to becoming an un-obscured quasar. W2246-0526 provides an extraordinary laboratory to study and model the properties and kinematics of gas in an extreme environment under strong feedback, at a time when the Universe was 1/10 of its current age: a system pushing the limits that can be reached during galaxy formation., Comment: 6 pages, 5 figures. Submitted to ApJ Letters

We present a complete census of all Herschel-detected sources within the six massive lensing clusters of the HST Frontier Fields (HFF). We provide a robust legacy catalogue of 263 sources with Herschel fluxes, primarily based on imaging from the Herschel Lensing Survey (HLS) and PEP/HerMES Key Programmes. We optimally combine Herschel, Spitzer and WISE infrared (IR) photometry with data from HST, VLA and ground-based observatories, identifying counterparts to gain source redshifts. For each Herschel-detected source we also present magnification factor (mu), intrinsic IR luminosity and characteristic dust temperature, providing a comprehensive view of dust-obscured star formation within the HFF. We demonstrate the utility of our catalogues through an exploratory overview of the magnified population, including more than 20 background sub-LIRGs unreachable by Herschel without the assistance gravitational lensing., Comment: 21 pages (+10 pages of tables), 18 figures, 9 tables. Published in MNRAS. All imaging, catalogues and SEDs are available on Rainbow (https://rainbowx.fis.ucm.es)

We present Early Science observations with the Large Millimeter Telescope, AzTEC 1.1 mm continuum images and wide bandwidth spectra (73-111 GHz) acquired with the Redshift Search Receiver, towards four bright lensed submillimetre galaxies identified through the Herschel Lensing Survey-snapshot and the SCUBA-2 Cluster Snapshot Survey. This pilot project studies the star formation history and the physical properties of the molecular gas and dust content of the highest redshift galaxies identified through the benefits of gravitational magnification. We robustly detect dust continuum emission for the full sample and CO emission lines for three of the targets. We find that one source shows spectroscopic multiplicity and is a blend of three galaxies at different redshifts (z=2.040, 3.252 and 4.680), reminiscent of previous high-resolution imaging follow-up of unlensed submillimetre galaxies, but with a completely different search method, that confirm recent theoretical predictions of physically unassociated blended galaxies. Identifying the detected lines as 12CO (J_up=2-5) we derive spectroscopic redshifts, molecular gas masses, and dust masses from the continuum emission. The mean H_2 gas mass of the full sample is (2.0 +- 0.2) x 10^11 M_sun/\mu, and the mean dust mass is (2.0+-0.2) x 10^9 M_sun/\mu, where \mu=2-5 is the expected lens amplification. Using these independent estimations we infer a gas-to-dust ratio of \delta_GDR=55-75, in agreement with other measurements of submillimetre galaxies. Our magnified high-luminosity galaxies fall on the same locus as other high-redshift submillimetre galaxies, extending the L'_CO - L_FIR correlation observed for local luminous and ultraluminous infrared galaxies to higher FIR and CO luminosities., Comment: Minor changes to match the published version

We report the redshift of an unlensed, highly obscured submillimetre galaxy (SMG), HS1700.850.1, the brightest SMG (S850um =19.1 mJy) detected in the JCMT/SCUBA-2 Baryonic Structure Survey, based on the detection of its CO line emission. Using the IRAM PdBI-WIDEX with 3.6GHz band width, we serendipitously detect an emission line at 150.6 GHz. From a search over 14.5 GHz in the 3-mm and 2-mm atmospheric windows, we confirm the identification of this line as CO(5-4) at z = 2.816, meaning that it does not reside in the z~2.30 proto-cluster in this field. Measurement of the 870um source size (<0.85") from the Sub-Millimeter Array (SMA) confirms a compact emission in a S870um =14.5mJy, LIR~10^13 Lsun component, suggesting an Eddington-limited starburst. We use the double-peaked CO line profile measurements along with the SMA size constraints to study the gas dynamics of a HyLIRG, estimating the gas and dynamical masses of HS1700.850.1. While HS1700.850.1 is one of the most extreme galaxies known in the Universe, we find that it occupies a relative void in the Lyman-Break Galaxy distribution in this field. Comparison with other extreme objects at similar epochs (HyLIRG Quasars), and cosmological simulations, suggests such an anti-bias of bright SMGs could be relatively common, with the brightest SMGs rarely occupying the most overdense regions at z=2-4., Comment: 9 pages, 6 figures, 3 tables, accepted in MNRAS

We present JCMT SCUBA-2 850microns submillimetre (submm) observations of 30 mid-infrared (mid-IR) luminous AGN, detected jointly by the WISE all-sky IR survey and the NVSS/FIRST radio survey. These rare sources are selected by their extremely red mid-infrared spectral energy distributions (SEDs) and compact radio counterparts. Further investigations show that they are highly obscured, have abundant warm AGN-heated dust and are thought to be experiencing intense AGN feedback. These galaxies appear to be consistent with an AGN-dominated galaxy, and could be a transient phase of merging galaxies. When comparing the number of submm galaxies (SMGs) detected serendipitously in the surrounding 1.5-arcmin to those in blank-field submm surveys, there is a very significant overdensity, of order 5, but no sign of radial clustering centred at our primary objects. The WISE/radio-selected AGN thus reside in 10-Mpc-scale overdense environments, that could be forming in pre-viralised clusters of galaxies. WISE/radio-selected AGNs appear to be the strongest signposts of high-density regions of active, luminous and dusty galaxies. SCUBA-2 850microns observations indicate that their submm fluxes are low compared to many popular AGN SED templates, hence the WISE/radio-selected AGNs have either less cold and/or more warm dust emission than normally assumed for typical AGN. Most of the targets are not detected, only four targets are detected at SCUBA-2 850microns, and have total IR luminosities >= 10^13 L_solar, if their redshifts are consistent with the subset of the 10 SCUBA-2 undetected targets with known redshifts, z ~ 0.44 - 2.86., Comment: 17 pages, 4 tables, 11 figures. arXiv admin note: text overlap with arXiv:1406.2506

We report the blind detection of 12CO emission from a Distant Red Galaxy, HS1700.DRG55. We have used the IRAM PdBI-WIDEX, with its 3.6GHz of instantaneous dual-polarization bandwidth, to target 12CO(3--2) from galaxies lying in the proto-cluster at z=2.300 in the field HS1700+64. If indeed this line in DRG55 is 12CO(3--2), it's detection at 104.9GHz indicates a z_CO=2.296. None of the other eight known z~2.30 proto-cluster galaxies lying within the primary beam (PB) are detected in 12CO, although the limits are ~2x worse towards the edge of the PB where several lie. The optical/near-IR magnitudes of DRG55 (R_AB>27, K_AB=22.3) mean that optical spectroscopic redshifts are difficult with 10m-class telescopes, but near-IR redshifts would be feasible. The 24um-implied SFR (210 M_odot yr-1), stellar mass (~10^11 M-odot) and 12CO line luminosity (3.6x10^10 K km s-1 pc^2) are comparable to other normal 12CO-detected star forming galaxies in the literature, although the galaxy is some ~2 mag (~6x) fainter in the rest-frame UV than 12CO-detected galaxies at z>2. The detection of DRG55 in 12CO complements three other 12CO detected UV-bright galaxies in this proto-cluster from previous studies, and suggests that many optically faint galaxies in the proto-cluster may host substantial molecular gas reservoirs, and a full blind census of 12CO in this overdense environment is warranted., Comment: 5 pages, matching the proof version in MNRAS

We present high-resolution (0.3'') ALMA 870um imaging of 52 sub-millimeter galaxies (SMGs) in the Ultra Deep Survey (UDS) field and investigate the size and morphology of the sub-millimeter (sub-mm) emission on 2-10kpc scales. We derive a median intrinsic angular size of FWHM=0.30$\pm$0.04'' for the 23 SMGs in the sample detected at a signal-to-noise ratio (SNR) >10. Using the photometric redshifts of the SMGs we show that this corresponds to a median physical half-light diameter of 2.4$\pm$0.2kpc. A stacking analysis of the SMGs detected at an SNR <10 shows they have sizes consistent with the 870um-bright SMGs in the sample. We compare our results to the sizes of SMGs derived from other multi-wavelength studies, and show that the rest-frame ~250um sizes of SMGs are consistent with studies of resolved 12CO (J=3-2 to 7-6) emission lines, but that sizes derived from 1.4GHz imaging appear to be approximately two times larger on average, which we attribute to cosmic ray diffusion. The rest-frame optical sizes of SMGs are around four times larger than the sub-millimeter sizes, indicating that the star formation in these galaxies is compact relative to the pre-existing stellar distribution. The size of the starburst region in SMGs is consistent with the majority of the star formation occurring in a central region, a few kpc in extent, with a median star formation rate surface density of 90$\pm$30Msol/yr/kpc$^2$, which may suggest that we are witnessing an intense period of bulge growth in these galaxies., Comment: 16 pages, 7 figures, accepted for publication in ApJ

The WISE mission has unveiled a rare population of high-redshift ($z=1-4.6$), dusty, hyper-luminous galaxies, with infrared luminosities $L_{\rm IR} > 10^{13}~L_{\odot}$, and sometimes exceeding $10^{14}~L_{\odot}$. Previous work has shown that their dust temperatures and overall far-IR SEDs are significantly hotter than expected for star-formation. We present here an analysis of the rest-frame optical through mid-IR SEDs for a large sample of these so-called "Hot, Dust-Obscured Galaxies" (Hot DOGs). We find that the SEDs of Hot DOGs are generally well modeled by the combination of a luminous, yet obscured AGN that dominates the rest-frame emission at $\lambda > 1\mu\rm m$ and the bolometric luminosity output, and a less luminous host galaxy that is responsible for the bulk of the rest optical/UV emission. Even though the stellar mass of the host galaxies may be as large as $10^{11}-10^{12}~M_{\odot}$, the AGN emission, with luminosities comparable to those of the most luminous QSOs known, require that either Hot DOGs have black hole masses significantly in excess of the local relations, or that they radiate significantly above the Eddington limit. We show that, while rare, the number density of Hot DOGs is comparable to that of equally luminous but unobscured (i.e., Type 1) QSOs. This is inconsistent with the trend of a diminishing fraction of obscured objects with increasing luminosity found for less luminous QSOs, possibly indicating a reversal in this relation at high luminosity, and that Hot DOGs are not the torus-obscured counterparts of the known optically selected, largely unobscured Hyper-Luminous QSOs. Hot DOGs may represent a different type of galaxy and thus a new component of the galaxy evolution paradigm. Finally, we discuss the environments of Hot DOGs and show that these objects are in regions as dense as those of known high-redshift proto-clusters.(Abridged), Comment: Accepted for publication in The Astrophysical Journal. Text and figures modified to address referee's comments. 16 pages, 12 figures, 2 tables

We present statistically significant detections at 850um of the Lyman Break Galaxy (LBG) population at z=3, 4, and 5 using data from the Submillimetre Common User Bolometer Array 2 (SCUBA-2) Cosmology Legacy Survey (S2CLS) in the United Kingdom Infrared Deep Sky Survey Ultra Deep Survey (UKIDSS-UDS) field. We employ a stacking technique to probe beneath the survey limit to measure the average 850um flux density of LBGs at z=3, 4, and 5 with typical ultraviolet luminosities of L(1700A)~10^29 erg/s/Hz. We measure 850um flux densities of (0.25 +/- 0.03, (0.41 +/- 0.06), and (0.88 +/- 0.23) mJy respectively, and find that they contribute at most 20 per cent to the cosmic far-infrared background at 850um. Fitting an appropriate range of spectral energy distributions to the z=3, 4, and 5 LBG stacked 24-850um fluxes, we derive infrared (IR) luminosities of L(8-1000um)~3.2, 5.5, and 11.0x10^11 Lsun (corresponding to star formation rates of ~50-200 Msun/yr) respectively. We find that the evolution in the IR luminosity density of LBGs is broadly consistent with model predictions for the expected contribution of luminous IR galaxy (LIRG) to ultraluminous IR galaxy (ULIRG) type systems at these epochs. We also see a strong positive correlation between stellar mass and IR luminosity. Our data are consistent with the main sequence of star formation showing little or no evolution from z=3 to 5. We have also confirmed that, for a fixed mass, the reddest LBGs (UV slope Beta -> 0) are indeed redder due to dust extinction, with SFR(IR)/SFR(UV) increasing by approximately an order of magnitude over -2