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1,744 results on '"Bishop, G"'

303. Increased mononuclear cell activation and apoptosis early after human liver transplantation is associated with a reduced frequency of acute rejection

Author

Jonsson, Julie R., primary, Gu, Wenyi, additional, Vanags, Daina M., additional, Bishop, G. Alex, additional, McCaughan, Geoffrey W., additional, Fawcett, Jonathon, additional, Lynch, Stephen V., additional, Balderson, Glenda A., additional, Powell, Elizabeth E., additional, and Clouston, Andrew D., additional

Published
2004
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317. Indefinite Survival and Functional Recovery of Limb Allografts in Rodents.

Author

Dubernard, Jean-Michel, Petruzzo, Palmina, Kanatani, Takako, Lanzetta, Marco, and Bishop, G. Alex

Abstract

Over the past decade, the focus of experimental limb transplantation has been to obtain functional recovery and indefinite survival, as reported in previous review articles [1]-[10]. These factors are of paramount importance in non-life-saving procedures, such as hand transplantation, where quality of life is the main indication for reconstruction. There is an additional ethical issue in clinical composite tissue transplantation where continuous and extensive use of powerful immunosuppressive drugs required to obtain long-term limb allograft survival might have serious and possibly fatal consequences. It is necessary to balance the opposing requirements for prolonged graft survival with the need to minimise immunosuppressive drug treatment. [ABSTRACT FROM AUTHOR]

Published
2007
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322. Touching In Biological Systems: A 3D Force Microscope

Author

Superfine, Richard, primary, Bishop, G., additional, Cummings, J., additional, Fisher, J., additional, Keller, K., additional, Matthews, G., additional, Sill, D., additional, Taylor II, R. M., additional, Vicci, L., additional, Weigle, C., additional, Welch, G., additional, and Wilde, B., additional

Published
2002
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331. Antecedents to hospital deaths

Author

Hillman, K. M., primary, Bristow, P. J., additional, Chey, T., additional, Daffurn, K., additional, Jacques, T., additional, Norman, S. L., additional, Bishop, G. F., additional, and Simmons, G., additional

Published
2001
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335. Real‐time reverse transcriptase–polymerase chain reaction (RT–PCR) for measurement of cytokine and growth factor mRNA expression with fluorogenic probes or SYBR Green I

Author

Yin, Jian Lin, primary, Shackel, Nicholas A, additional, Zekry, Amany, additional, McGuinness, Peter H, additional, Richards, Craig, additional, Van Der Putten, Karien, additional, McCaughan, Geoffrey W, additional, Eris, Josette M, additional, and Bishop, G Alex, additional

Published
2001
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347. Molecular pathogenesis of liver disease: an approach to hepatic inflammation, cirrhosis and liver transplant tolerance

Author

McCaughan, Geoffrey W., primary, Gorrell, Mark D., additional, Bishop, G. Alex, additional, Abbott, Catherine A., additional, Shackel, Nicholas A., additional, McGuinness, Peter H., additional, Levy, Miriam T., additional, Sharland, Alexandra F., additional, Bowen, David G., additional, Yu, Denise, additional, Slaitini, Loubnah, additional, Church, W. Bret, additional, and Napoli, John, additional

Published
2000
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348. Interleukin-12 (IL-12p70) promotes induction of highly potentTh1-like CD4+CD25+ T regulatory cells that inhibit allograft rejection in unmodified recipients.

Author

Nirupama Darshan Verma, Milne Hall, Bruce, Plain, Karren Michelle, Robinson, Catherine M., Boyd, Rochelle, Tran, Giang T., Chuanmin Wang, Bishop, G. Alex, and Hodgkinson, Suzanne J.

Subjects
T cells, ANTIGEN receptors, GRAFT rejection, CARDIAC surgery, CELL culture
Abstract

In rat models, CD4+CD25+ T regulatory cells (Treg) play a key role in the induction and maintenance of antigen-specific transplant tolerance, especially in DA rats with PVG cardiac allografts (1, 2).We have previously described generation of alloantigen-specific Treg (Ts1), by culture of naïve natural CD4+CD25+ Treg (nTreg) with specific alloantigen and IL-2 for 4 days. These cells express mRNA for IFN-γ receptor (ifngr ) and suppress donor but not third party cardiac allograft rejection mediated by alloreactive CD4+ T cells at ratios of <1:10. Here, we show that Ts1 also expressed the IL-12p70 specific receptor (il-12rβ2) and that rIL-12p70 can induce their proliferation. Ts1 cells re-cultured with rIL-12p70 alone or rIL-12p70 and recombinant interleukin-2 (rIL-2), suppressed proliferation of CD4+ T cells in mixed lymphocyte culture at <1:1024, whereas Ts1 cells re-cultured with rIL-2 and alloantigen only suppressed at 1:32–64. The rIL-12p70 alloactivated Ts1 cells markedly delayed PVG, but not third party Lewis, cardiac allograft rejection in normal DA recipients.Ts1 cells re-cultured for 4 days with rIL-12p70 alone, but not those re-cultured with rIL-12p70 and rIL-2, expressed more il-12rβ2, t-bet, and ifn-γ, and continued to express the markers of Ts1 cells, foxp3, ifngr, and il-5 indicating Th1-like Treg were induced. Ts1 cells re-cultured with rIL-2 and alloantigen remained of the Ts1 phenotype and did not suppress cardiac graft rejection in normal DA rats.We induced highly suppressive Th1-like Treg from naïve nTreg in 7 days by culture with alloantigen, first with rIL-2 then with rIL-12p70. These Th1-like Treg delayed specific donor allograft rejection demonstrating therapeutic potential. [ABSTRACT FROM AUTHOR]

Published
2014
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349. Interleukin-12 (IL-12p70) promotes induction of highly potent Th1-like CD4+CD25+T regulatory cells that inhibit allograft rejection in unmodified recipients.

Author

Verma, Nirupama D., Hall, Bruce M., Plain, Karren M., Robinson, Catherine M., Boyd, Rochelle, Tran, Giang T., Chuanmin Wang, Bishop, G. Alex, and Hodgkinson, Suzanne J.

Subjects
INTERLEUKIN-12, LABORATORY rats, CD4 antigen, HOMOGRAFTS, MESSENGER RNA, INTERLEUKINS, T cells, MIXED lymphocyte culture test
Abstract

In rat models, CD4+CD25+ T regulatory cells (Treg) play a key role in the induction and maintenance of antigen-specific transplant tolerance, especially in DA rats with PVG cardiac allografts (1, 2). We have previously described generation of alloantigen-specific Treg (Ts1), by culture of naïve natural CD4+CD25+ Treg (nTreg) with specific alloantigen and IL-2 for 4 days. These cells express mRNA for IFN-γ receptor (ifngr) and suppress donor but not third party cardiac allograft rejection mediated by alloreactive CD4+ T cells at ratios of <1:10. Here, we show that Ts1 also expressed the IL-12p70 specific receptor (il-12rβ2) and that rIL-12p70 can induce their proliferation. Ts1 cells re-cultured with rIL-12p70 alone or rIL-12p70 and recombinant interleukin-2 (rIL-2), suppressed proliferation of CD4+ T cells in mixed lymphocyte culture at <1:1024, whereas Ts1 cells re-cultured with rIL-2 and alloantigen only suppressed at 1:32-64. The rIL-12p70 alloactivated Ts1 cells markedly delayed PVG, but not third party Lewis, cardiac allograft rejection in normal DA recipients. Ts1 cells re-cultured for 4 days with rIL-12p70 alone, but not those re-cultured with rIL-12p70 and rIL-2, expressed more il-12rβ2, t-bet, and ifn-γ, and continued to express the markers of Ts1 cells, foxp3, ifngr, and il-5 indicating Th1-like Treg were induced. Ts1 cells re-cultured with rIL-2 and alloantigen remained of the Ts1 phenotype and did not suppress cardiac graft rejection in normal DA rats. We induced highly suppressive Th1-like Treg from naïve nTreg in 7 days by culture with alloantigen, first with rIL-2 then with rIL-12p70. These Th1-like Treg delayed specific donor allograft rejection demonstrating therapeutic potential. [ABSTRACT FROM AUTHOR]

Published
2014
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