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Your search keyword '"Beseler, Cheryl"' showing total 114 results
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114 results on '"Beseler, Cheryl"'

113. Sleep patterns and risk of injury among adolescent farm residents

Author

Peter Y. Chen, Cheryl L. Beseler, Lorann Stallones, Stallones, L, Beseler, Cheryl, and Chen, Peter

Subjects
Male, Rural Population, medicine.medical_specialty, Colorado, Adolescent, Epidemiology, Cross-sectional study, adolescent, adult, controlled study, daytime somnolence, demography, female, human, human experiment, injury, logistic regression analysis, male, multivariate analysis, review, risk factor, sleep pattern, social aspect, univariate analysis MeSH: Adolescent, Agriculture, Cross-Sectional Studies, Female, Health Surveys, Humans, Risk Factors, Sleep, Sleep Deprivation, Wounds and Injuries [EMTREE medical terms], education, Poison control, Suicide prevention, Occupational safety and health, Injury prevention, Medicine, business.industry, Public Health, Environmental and Occupational Health, Sleep in non-human animals, Alertness, Sleep deprivation, Public Health and Health Services, Physical therapy, Wounds and Injuries, medicine.symptom, business, Demography
Abstract

Sleep patterns have been associated with decreased alertness among adolescents and to a limited extent, increased risk of injuries. The purpose of this study is to describe the relationship between sleep patterns and injury occurrence among adolescents aged 13 to 18 years living on farms in Colorado.A cross-sectional survey of randomly selected Colorado farm residents aged 13 to 18 years was conducted between August 2003 and April 2004. A total of 262 youth completed the study. Information was obtained on injuries within the preceding year, sleep patterns, sleep hours, daytime sleepiness, and a number of social and demographic variables. Univariate analyses were done to describe relationships of study variables with injuries. Multivariate modeling was done to assess sleep patterns that were associated with injuries controlling for other variables.Sleep patterns associated with increased risk of injuries (p0.05) included oversleeping and having been late for class; falling asleep in afternoon classes; ever being up past 3 am; sleeping less than an average of 9.25 hours per night on weekends, and on school nights and weekends combined; and sleeping less than an average of 8.5 hours on weekends, and on school nights and weekends combined.Sleep patterns were significantly associated with occurrence of injuries.

Published
2005

114. Estrogen-DNA Adducts and Breast Cancer Risk in Premenopausal Asian Women.

Author

Lin CH, Zahid M, Kuo WH, Hu FC, Wang MY, Chen IC, Beseler CL, Mondal B, Lu YS, Rogan EG, and Cheng AL

Subjects
Female, Humans, DNA Adducts, Cytochrome P-450 CYP1A1, Case-Control Studies, Estrogens metabolism, Breast Neoplasms etiology, Breast Neoplasms genetics
Abstract

The incidence of breast cancer among premenopausal women has been increasing rapidly in recent decades in East Asia. This case-control study investigated whether estrogen-DNA adducts were associated with breast cancer risk in Taiwan. The control group (n = 146) comprised healthy female volunteers and women with non-proliferative breast disease. The case group (n = 221) comprised women either with proliferative benign breast disease or breast cancer. The ratios of estrogen-DNA adducts to their respective metabolites and conjugates in plasma were analyzed using ultraperformance LC/MS-MS. The SNPs of CYP1A1, CYP1B1, and COMT were genotyped. Logistic regression model was used to compare the estrogen-DNA adduct ratios between the two groups. The estrogen-DNA adduct ratio in the case group was significantly higher than that in the control group (median ratio: 58.52 vs. 29.36, P = 0.004). A multiple logistic regression model demonstrated that a unit increase in the natural log of the estrogen-DNA adduct ratio in premenopausal women was a significant predictor of breast cancer risk, with an estimated hazard ratio of 1.718 (1.444-2.046, P < 0.001). However, the CYP1A1, CYP1B1, and COMT SNPs were not associated with the estrogen-DNA adduct ratios. In conclusion, plasma estrogen-DNA adduct ratio was associated with the presence of breast cancer or proliferating benign breast disease in premenopausal women in Taiwan., Prevention Relevance: This study provides evidence that endogenous estrogen-induced genotoxicity may contribute to the carcinogenesis of breast cancer in premenopausal Asian women. This work could have important preventive implication for the emerging disease in East Asia., (©2022 American Association for Cancer Research.)

Published
2023
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