301. The Genetic Variant on Chromosome 10p14 Is Associated with Risk of Colorectal Cancer: Results from a Case-Control Study and a Meta-Analysis
- Author
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Xuzai Lu, Tingting Li, Li Zou, Wei Chen, Xiaorong Li, Jigui Chen, Jiao Lou, Sheng Wei, Beibei Cao, Shaofa Nie, Qin Qin, Jieyun Yin, Rong Zhong, Li Liu, Xiaoping Miao, Juntao Ke, and Beibei Zhu
- Subjects
Male ,Oncology ,China ,medicine.medical_specialty ,Clinical Research Design ,Epidemiology ,lcsh:Medicine ,Single-nucleotide polymorphism ,Genome-wide association study ,Biology ,Bioinformatics ,Polymorphism, Single Nucleotide ,Genetic Heterogeneity ,Polymorphism (computer science) ,Internal medicine ,medicine ,Humans ,SNP ,Genetic Predisposition to Disease ,lcsh:Science ,Aged ,Molecular Epidemiology ,Multidisciplinary ,Chromosomes, Human, Pair 10 ,Genetic heterogeneity ,lcsh:R ,Case-control study ,Publication bias ,Middle Aged ,Biomarker Epidemiology ,Case-Control Studies ,Genetic Epidemiology ,Meta-analysis ,Medicine ,Female ,lcsh:Q ,Meta-Analyses ,Colorectal Neoplasms ,Cancer Epidemiology ,Research Article - Abstract
BACKGROUND: A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results. METHODS: We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the χ²-based Q statistic test and Egger's test, respectively. RESULTS: In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95%CI: 0.54-0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95%CI: 0.89-0.93, P(heterogeneity) >0.05) in European population and 0.86 (95%CI: 0.78-0.96, P(heterogeneity)
- Published
- 2013