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202. The feasibility of preventing mother-to-child transmission of HIV using peer counselors in Zimbabwe

Author

Lynda Stranix-Chibanda, Agnes Mahomva, Avinash K. Shetty, Anna Miller, Elizabeth Chirapa, Winfreda Chandisarewa, Caroline Marangwanda, Yvonne Maldonado, and Micah Simoyi

Subjects
lcsh:Immunologic diseases. Allergy, Program evaluation, medicine.medical_specialty, education.field_of_study, Pediatrics, Nevirapine, business.industry, Research, Voluntary counseling and testing, Public health, Population, Human immunodeficiency virus (HIV), virus diseases, Developing country, medicine.disease_cause, Peer counselors, Virology, Family medicine, medicine, Molecular Medicine, Pharmacology (medical), lcsh:RC581-607, education, business, medicine.drug
Abstract

Background Prevention of mother-to-child transmission of HIV (PMTCT) is a major public health challenge in Zimbabwe. Methods Using trained peer counselors, a nevirapine (NVP)-based PMTCT program was implemented as part of routine care in urban antenatal clinics. Results Between October 2002 and December 2004, a total of 19,279 women presented for antenatal care. Of these, 18,817 (98%) underwent pre-test counseling; 10,513 (56%) accepted HIV testing, of whom 1986 (19%) were HIV-infected. Overall, 9696 (92%) of women collected results and received individual post-test counseling. Only 288 men opted for HIV testing. Of the 1807 HIV-infected women who received posttest counseling, 1387 (77%) collected NVP tablet and 727 (40%) delivered at the clinics. Of the 1986 HIV-infected women, 691 (35%) received NVPsd at onset of labor, and 615 (31%) infants received NVPsd. Of the 727 HIV-infected women who delivered in the clinics, only 396 women returned to the clinic with their infants for the 6-week follow-up visit; of these mothers, 258 (59%) joined support groups and 234 (53%) opted for contraception. By the end of the study period, 209 (53%) of mother-infant pairs (n = 396) came to the clinic for at least 3 follow-up visits. Conclusion Despite considerable challenges and limited resources, it was feasible to implement a PMTCT program using peer counselors in urban clinics in Zimbabwe.

Published
2008
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203. Tissue Distribution of Ciclesonide and Budesonide in Mice

Author

Anna Miller-Larsson, E. Evetovics, P. Sjolin, A. Johansson, Staffan Edsbäcker, and U. Mars

Subjects
Budesonide, chemistry.chemical_compound, chemistry, Immunology, medicine, Immunology and Allergy, Tissue distribution, Ciclesonide, Pharmacology, medicine.drug
Published
2006
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204. Blood Relations

Author

Pollock, Sharon, Ruggiero, Rob (director); Hare, Eugene (set designer); Henninge, Bob (lighting designer); Hare, Mark (costume designer, wig designer); Ingraham, Richard (sound designer); Aprahamian, Steve (music composer), Bates, Carol; Oiler, Melissa; Martens, Tina M.; Dilger, James S.; Boeman, Melanie; Mancini, Anna; Miller, Ron; Noch, Duane; Burgess, Kristin; Klein, Jessica; Pekarcik, Garyanne; Potepan, Slavica; Sullivan, Laurel; Mahovlic, Keith E.; Grady, Michael; Dowling, Stuart E., Dick, Ron, Pollock, Sharon, Ruggiero, Rob (director); Hare, Eugene (set designer); Henninge, Bob (lighting designer); Hare, Mark (costume designer, wig designer); Ingraham, Richard (sound designer); Aprahamian, Steve (music composer), Bates, Carol; Oiler, Melissa; Martens, Tina M.; Dilger, James S.; Boeman, Melanie; Mancini, Anna; Miller, Ron; Noch, Duane; Burgess, Kristin; Klein, Jessica; Pekarcik, Garyanne; Potepan, Slavica; Sullivan, Laurel; Mahovlic, Keith E.; Grady, Michael; Dowling, Stuart E., and Dick, Ron

Abstract

Photo of Melissa Oiler as Lizzy Borden backstage during Cleveland State University's 1992 production of "Blood Relations."

Published
1992

205. Incidence of Ceramic Liner Malseating in Trident® Acetabular Shell.

Author

Anna Miller, Edwin Su, Mathias Bostrom, Bryan Nestor, and Douglas Padgett

Subjects
*CERAMICS in surgery, *SURGICAL instruments, *SURGICAL complications, *COHORT analysis, *TOTAL hip replacement, *ORTHOPEDICS, *RADIOGRAPHY
Abstract

Abstract  The low wear rates associated with ceramic hip articulations have made them a popular bearing for younger patients. Although few complications have been observed, one report revealed several instances of incomplete seating of the ceramic liner in the metallic shell. We performed a cohort study of consecutive THAs using a ceramic-ceramic bearing. Radiographic analysis showed 50 (7.2%) of the group of 694 hips had evidence of incomplete seating of the liner in the metallic shell. Although we observed no adverse effects at 6 to 12 weeks, we encourage surgeons to carefully assess liner placement in the metal shell at the time of surgery to avoid this unintended consequence and to assess placement at the time of followup so patients can be properly followed when incomplete seating is identified. Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence. [ABSTRACT FROM AUTHOR]

Published
2009
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206. Sarracenia purpurea

Author

Anna Miller, Anna Miller, Anna Miller, and Anna Miller

Abstract

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1464502%5DMICH-V-1464502, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1464502/MICH-V-1464502/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1893

207. Polygonatum pubescens

Author

Anna Miller, Anna Miller, Anna Miller, and Anna Miller

Abstract

Angiosperms, http://name.umdl.umich.edu/IC-HERB00IC-X-1339306%5DMICH-V-1339306, https://quod.lib.umich.edu/cgi/i/image/api/thumb/herb00ic/1339306/MICH-V-1339306/!250,250, The University of Michigan Library provides access to these materials for educational and research purposes. Some materials may be protected by copyright. If you decide to use any of these materials, you are responsible for making your own legal assessment and securing any necessary permission. If you have questions about the collection, please contact the Herbarium professional staff: herb-dlps-help@umich.edu. If you have concerns about the inclusion of an item in this collection, please contact Library Information Technology: libraryit-info@umich.edu., https://www.lib.umich.edu/about-us/policies/copyright-policy

Published
1893

208. Book reviews

Author

Cyril O. Houle, Diana J. Ironside, David Tiedeman, Anna Miller-Tiedeman, and Peter Sachsenmeier

Subjects
Education
Published
1977
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209. Some Observations on the All-State Career Education Concert

Author

David V. Tiedeman, Anna Miller-Tiedeman, and Richard J. Feller

Subjects
Organizational Behavior and Human Resource Management, The All, State (polity), Cognitive Information Processing, media_common.quotation_subject, Pedagogy, Career education, Career portfolio, Psychology, General Psychology, Applied Psychology, Education, media_common
Published
1982
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211. The Trend of Life in the Human Career

Author

David V. Tiedeman and Anna Miller-Tiedeman

Subjects
Organizational Behavior and Human Resource Management, Cognitive Information Processing, Education theory, 05 social sciences, Individual development, Education, 050106 general psychology & cognitive sciences, 0502 economics and business, Pedagogy, 0501 psychology and cognitive sciences, Sociology, Career portfolio, 050203 business & management, General Psychology, Applied Psychology, Career choice, Career development
Published
1985
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212. An analysis of extracellular single muscle fibre action potential field ?Modelling results

Author

Anna Miller-Larsson

Subjects
Physics, General Computer Science, Field (physics), Basis (linear algebra), business.industry, Muscles, Potential field, Action Potentials, In Vitro Techniques, Models, Biological, Action (physics), Optics, Amplitude, Single muscle, Extracellular, Animals, Humans, Muscle fibre, Biological system, business, Cybernetics, Biotechnology
Abstract

The radial variability of extracellular single muscle fibre action potential (SFAP) field was studied on the basis of an SFAP theoretical model originally constructed by Rosenfalck (1969). Amplitude and time parameters of the SFAP as a function of the radial distance r less than or equal to 10 mm from the fibre were described by simple mathematical expressions. The results obtained were compared with existing experimental data from different authors and discussed in detail.

Published
1985
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213. Two Jazz Solos

Author

David V. Tiedeman, Anna Miller-Tiedeman, and Richard J. Feller

Subjects
Organizational Behavior and Human Resource Management, media_common.quotation_subject, Art history, Art, Jazz, General Psychology, Applied Psychology, Education, media_common
Published
1982
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215. Career Decision Making and its Evaluation

Author

Anna Miller-Tiedeman

Subjects
Organizational Behavior and Human Resource Management, Medical education, Secondary education, media_common.quotation_subject, Cognitive Information Processing, Applied psychology, Self-concept, Education, Self-actualization, Career decision, Psychology, Career portfolio, General Psychology, Applied Psychology, Career counseling, media_common, Career development
Published
1979
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217. Helping the Career Education Community Grow

Author

David V. Tiedeman, Anna Miller-Tiedeman, and Richard W. Feller

Subjects
Organizational Behavior and Human Resource Management, business.industry, Pedagogy, Career education, Sociology, Public relations, business, General Psychology, Applied Psychology, Education
Published
1983
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218. TGFβ-induced matrix production by bronchial fibroblasts in asthma: Budesonide and formoterol effects

Author

Gunilla Westergren-Thorsson, Lizbet Todorova, Leif Bjermer, and Anna Miller-Larsson

Subjects
Budesonide, Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, Decorin, Bronchi, Lung fibroblasts, Extracellular matrix, Transforming Growth Factor beta, Internal medicine, Formoterol Fumarate, Administration, Inhalation, medicine, Humans, Zymography, Budesonide/formoterol, Chromatography, Tissue Inhibitor of Metalloproteinase-1, business.industry, Biglycan, TGFβ1, Fibroblasts, Middle Aged, Metalloproteinases, Asthma, Bronchodilator Agents, Endocrinology, Ethanolamines, Electrophoresis, Polyacrylamide Gel, Female, Formoterol, Collagen, business, Ex vivo, medicine.drug
Abstract

SummaryTo investigate the mechanisms of enhanced airway deposition of subepithelial collagen in asthma and its sensitivity to drug therapy with combination of an inhaled glucocorticosteroid (GC) and a long-acting β2-agonist (LABA), a cell model system involving bronchial fibroblasts derived from biopsies from patients with stable mild-to-moderate asthma has been used. To mimic unstable conditions and severe asthma, fibroblasts were stimulated ex vivo with TGFβ1. Primary fibroblasts established from central bronchial biopsies from 8 asthmatic patients were incubated for 24 h with 0.4% serum or TGFβ1 (10 ng/ml) with/without the GC budesonide (BUD; 10 nM) and/or the LABA formoterol (FORM; 0.1 nM). Procollagen peptide I (PICP), metalloproteinase (MMP)-1 and tissue inhibitor of MMPs (TIMP-1) were determined in culture media using ELISA while the activity of MMP-2, -3, -9 by zymography. Metabolically labeled proteoglycans, biglycan and decorin, associated with collagen fibrillation/deposition, were separated using chromatography and SDS-PAGE. The levels of PICP and biglycan were increased 2-fold by TGFβ1 (p

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219. Budesonide/formoterol effects on metalloproteolytic balance in TGFβ-activated human lung fibroblasts

Author

Anna Miller-Larsson, Gunilla Westergren-Thorsson, Eylem Gürcan, and Lizbet Todorova

Subjects
Pulmonary and Respiratory Medicine, Budesonide, medicine.medical_specialty, Combination therapy, Respiratory System, TIMP-1, Transforming Growth Factor beta, Fibrosis, Formoterol Fumarate, Internal medicine, medicine, Humans, Formoterol, Lung, Cells, Cultured, TGF beta 1, Tissue Inhibitor of Metalloproteinase-1, biology, business.industry, TGFβ1, Fibroblasts, respiratory system, medicine.disease, Metalloproteinases, Asthma, Matrix Metalloproteinases, Bronchodilator Agents, respiratory tract diseases, Endocrinology, Matrix Metalloproteinase 9, Budesonide/formoterol, Ethanolamines, biology.protein, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Proteoglycans, business, Glucocorticoid, medicine.drug
Abstract

In the airways of asthmatic patients, activated fibroblasts account for an excessive matrix production including proteoglycans (PGs). Transforming growth factor-beta (TGFbeta), metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play key roles in matrix turnover. It is unclear whether asthma therapy with combination of inhaled glucocorticoids and long-acting beta(2)-agonists affects metalloproteolytic equilibrium and by that counteracts airway fibrosis. The effects of the glucocorticoid, budesonide, and the long-acting beta(2)-agonist, formoterol, on the PG production and the activity of PGs' main regulators: MMP-3, MMP-9, MMP-2 and TIMP-1 were investigated in human lung fibroblasts (HFL-1) treated for 24h with TGFbeta1 (10 ng/ml) without/with budesonide (10(-9) to 10(-6)M) and/or formoterol (10(-11) to 10(-6)M). TGFbeta1 significantly increased production of PGs and TIMP-1, and the activity of MMP-3, MMP-9 and MMP-2. Concurrent budesonide/formoterol combination counteracted the enhanced: PG and TIMP-1 production, MMP-9 activity and MMP-9/TIMP-1 ratio, whereas MMP-2 and MMP-3 were not affected and so their ratios to TIMP-1 were significantly increased. Budesonide or formoterol alone achieved equal effects as budesonide/formoterol on MMP-9 and MMP-9/TIMP-1 ratio but had no effects on TIMP-1, MMP-2 or MMP-3. In the formoterol absence, higher budesonide concentrations were required to reduce the PG production, whereas formoterol alone had no effects. These results suggest that the budesonide/formoterol combination enhanced metalloproteolytic activity of human lung fibroblasts via a synergistic decrease of TIMP-1, and that this mechanism may be involved in the synergistic inhibition of the TGFbeta1-induced PG production. This implies that budesonide/formoterol combination therapy can counteract excessive matrix production and thus pathological airway fibrotic remodeling in asthma.

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220. The All-State Career Education Choir

Author

Anna Miller-Tiedeman, David V. Tiedeman, and Richard J. Feller

Subjects
Program evaluation, Organizational Behavior and Human Resource Management, media_common.quotation_subject, Career education, Education, The All, State (polity), Postsecondary education, Pedagogy, Choir, Sociology, Education policy, General Psychology, Applied Psychology, media_common
Published
1982
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221. Silhouette: Caleb Bentley (1762-1851)

Author

Sandy Spring Museum Archives, Farquhar, Anna Miller, 1871-1931, Sandy Spring Museum Archives, and Farquhar, Anna Miller, 1871-1931

Abstract

Silhouette created by Anna Miller Farquhar in 1929 depicting Caleb Bentley of Sandy Spring, Maryland. Original likely created at time Caleb's marriage to Henrietta Thomas in 1807.

Published
1929

222. Silhouette: Margaret Elgar Farquhar Hallowell (1798-1875

Author

Sandy Spring Museum Archives, Farquhar, Anna Miller, 1871-1931, Sandy Spring Museum Archives, and Farquhar, Anna Miller, 1871-1931

Abstract

Silhouette created by Anna Miller Farquhar in 1929 depicting Margaret Elgar Farquhar Hallowell of Sandy Spring, Maryland. Original likely created at time Anna's marriage to Benjamin Hallowell in 1824.

Published
1929

223. Silhouette: Benjamin Hallowell (1799-1877)

Author

Sandy Spring Museum Archives, Farquhar, Anna Miller, 1871-1931, Sandy Spring Museum Archives, and Farquhar, Anna Miller, 1871-1931

Abstract

Silhouette created by Anna Miller Farquhar in 1929 depicting Benjamin Hallowell of Sandy Spring, Maryland. Original likely created at time Benjamin's marriage to Anna Farquhar in 1824.

Published
1929

224. Letter: Anna M. Farquhar to Dr. Tumbleson, ca. 1928.

Author

Sandy Spring Museum Archives, Farquhar, Anna Miller, 1871-1931, Sandy Spring Museum Archives, and Farquhar, Anna Miller, 1871-1931

Abstract

Note dated ca. 1928 from Anna M. Farquhar to Dr. Charles Tumbleson in Olney, Maryland regarding the health of an unnamed child.

Published
1928

226. Local history cards for the Miller family

Author

Miller, Reson, 1847-; Miller, Abraham; Miller, Abraham, 1832-1868; Miller, Abraham, 1817-; Miller, Adam, 1817-; Miller, Adam H., 1839-; Miller, Alfred, 1821-; Miller, Arthur B., 1876-; Miller, Alexander, 1838-; Miller, Anderson; Miller, Anna; Miller, Carlton B.; Miller, Catharine, 1780-; Miller, Charles, 1790-; Miller, Charles E.; Miller, Charles, -1867; Nickey, Christena; Miller, Daniel, 1813-; Miller, Daniel; Miller, Edward; Miller, Elijah, 1825-; Smell, Elizabeth; Miller, Emma; Miller, Emily F., 1861-; Miller, Frank, 1852-; Miller, Frank, 1858-; Miller, George W.; Miller, Harvey A., 1835-; Miller, Henry, 1798-; Miller, Henry, 1835-; Miller, Hannah, 1841-; Miller, Harrison, 1845-; Lewis, Helda; Miller, Henry, 1809-; Miller, Henry, 1831-; Miller, Henry, 1835-; Miller, Ida B., 1870-; Arrasmith, Ida M., 1862-; Miller, Ira; Miller, Isaac; Miller, Isaac N., 1827-; Miller, J. W.; Miller, Jacob, 1817-; Miller, Jackson, 1817-1898; Miller, Jacob, -1855; Miller, Jacob; Miller, Jacob W., 1816-; Miller, James, -1816; Miller, James, 1836-; Miller, James, -1857; Miller, Jefferson, 1841-; Miller, Jeffrey; Miller, Jeremiah; Miller, John; Miller, John, 1830-; Miller, John, 1854-; Miller, John, 1824-; Miller, John, 1832-; Miller, John, -1848; Miller, Jonathan, 1859-; Miller, Joseph, 1862-; Miller, Jackson, 1818-; Miller, James R., 1848-; Miller, L. A., 1844-; Miller, Leonidas, 1854-; Neff, Leana; Miller, Levi, 1801-1871; Kidnocker, Lucinda; Miller, Lucinda, 1847-1907; Miller, Margaret, 1846-; Miller, Margaret; Miller, Mary, 1816-1882; Braddock, Mary Ann, 1837-; Miller, Mary, 1838-; Fleming, Mary E., 1827-; Miller, Mary E., 1843-; Miller, Noah, 1846-; Miller, Nancy, 1807-; Miller, Nancy E., 1840-; Miller, Oliver, 1847-; Miller, Peter; Miller, Perry M.; Miller, Peter, 1805-1868; Miller, Reuhanna, -1879; Miller, Richard Noah, 1845-; Miller, Robert O.; Johnson, Susan; Miller, Solomon, 1817-; Miller, Steward, 1875-; Miller, Squire, 1847-; Miller, Sophia, 1845-; Miller, Simon, 1810-; Mil, Bennett, Elaine C., Miller, Reson, 1847-; Miller, Abraham; Miller, Abraham, 1832-1868; Miller, Abraham, 1817-; Miller, Adam, 1817-; Miller, Adam H., 1839-; Miller, Alfred, 1821-; Miller, Arthur B., 1876-; Miller, Alexander, 1838-; Miller, Anderson; Miller, Anna; Miller, Carlton B.; Miller, Catharine, 1780-; Miller, Charles, 1790-; Miller, Charles E.; Miller, Charles, -1867; Nickey, Christena; Miller, Daniel, 1813-; Miller, Daniel; Miller, Edward; Miller, Elijah, 1825-; Smell, Elizabeth; Miller, Emma; Miller, Emily F., 1861-; Miller, Frank, 1852-; Miller, Frank, 1858-; Miller, George W.; Miller, Harvey A., 1835-; Miller, Henry, 1798-; Miller, Henry, 1835-; Miller, Hannah, 1841-; Miller, Harrison, 1845-; Lewis, Helda; Miller, Henry, 1809-; Miller, Henry, 1831-; Miller, Henry, 1835-; Miller, Ida B., 1870-; Arrasmith, Ida M., 1862-; Miller, Ira; Miller, Isaac; Miller, Isaac N., 1827-; Miller, J. W.; Miller, Jacob, 1817-; Miller, Jackson, 1817-1898; Miller, Jacob, -1855; Miller, Jacob; Miller, Jacob W., 1816-; Miller, James, -1816; Miller, James, 1836-; Miller, James, -1857; Miller, Jefferson, 1841-; Miller, Jeffrey; Miller, Jeremiah; Miller, John; Miller, John, 1830-; Miller, John, 1854-; Miller, John, 1824-; Miller, John, 1832-; Miller, John, -1848; Miller, Jonathan, 1859-; Miller, Joseph, 1862-; Miller, Jackson, 1818-; Miller, James R., 1848-; Miller, L. A., 1844-; Miller, Leonidas, 1854-; Neff, Leana; Miller, Levi, 1801-1871; Kidnocker, Lucinda; Miller, Lucinda, 1847-1907; Miller, Margaret, 1846-; Miller, Margaret; Miller, Mary, 1816-1882; Braddock, Mary Ann, 1837-; Miller, Mary, 1838-; Fleming, Mary E., 1827-; Miller, Mary E., 1843-; Miller, Noah, 1846-; Miller, Nancy, 1807-; Miller, Nancy E., 1840-; Miller, Oliver, 1847-; Miller, Peter; Miller, Perry M.; Miller, Peter, 1805-1868; Miller, Reuhanna, -1879; Miller, Richard Noah, 1845-; Miller, Robert O.; Johnson, Susan; Miller, Solomon, 1817-; Miller, Steward, 1875-; Miller, Squire, 1847-; Miller, Sophia, 1845-; Miller, Simon, 1810-; Mil, and Bennett, Elaine C.

Abstract

This archival material has been provided for educational purposes. Ball State University Libraries recognizes that some historic items may include offensive content. Our statement regarding objectionable content is available at: https://dmr.bsu.edu/digital/about

228. Group Books

Author

Carole Hamilton, Anna Miller, and Paula Wood

Subjects
Developmental and Educational Psychology, Education
Published
1987
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231. The All-State Career Education Choir: Uncle Sam, Conductor

Author

David V. Tiedeman, Richard J. Feller, and Anna Miller-Tiedeman

Subjects
Organizational Behavior and Human Resource Management, The All, State (polity), media_common.quotation_subject, Choir, Career education, Psychology, General Psychology, Applied Psychology, Education, Management, media_common, Conductor
Published
1982
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232. From Federalism To Nationalism in Career Education

Author

Richard W. Feller, Anna Miller-Tiedeman, and David V. Tiedeman

Subjects
Organizational Behavior and Human Resource Management, Political science, Career education, Federalism, Public administration, General Psychology, Applied Psychology, Cultural production and nationalism, Education, Nationalism
Published
1983
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234. Bicondylar Tibial Plateau Fractures: What Predicts Infection?

Author

Olszewski N, Manzano G, Wilson E, Joseph N, Vallier H, Pawlak A, Kottmeier S, Miller A, Gary J, Namm J, Miller A, Gupte G, Rodriguez-Buitrago A, Obremskey W, Willier D 3rd, Marcantonio A, Phieffer L, Sheridan E, Li K, Karunakar M, Vargas-Hernandez J, Yuan B, Shapiro J, Pratson L, Friess D, Jenkins D, Leighton R, Alqudhaya R, Aljilani W, Mullis B, Gruenwald K, Ollivere B, Myint Y, Odom C, Spitler C, Suwak P, Shah S, Rocha D, Horwitz D, and Tornetta P 3rd

Subjects
Fracture Fixation, Fracture Fixation, Internal, Humans, Open Fracture Reduction, Retrospective Studies, Treatment Outcome, Tibial Fractures etiology, Tibial Fractures surgery
Abstract

Objectives: The purpose of this study was to identify the patient, injury, and treatment factors associated with infection of bicondylar plateau fractures and to evaluate whether center variation exists., Design: Retrospective review., Setting: Eighteen academic trauma centers., Patients/participants: A total of 1,287 patients with 1,297 OTA type 41-C bicondylar tibia plateau fractures who underwent open reduction and internal fixation were included. Exclusion criteria were follow-up less than 120 days, insufficient documentation, and definitive treatment only with external fixation., Intervention: Open reduction and internal fixation., Main Outcome Measurements: Superficial and deep infection., Results: One hundred one patients (7.8%) developed an infection. In multivariate regression analysis, diabetes (DM) (OR [odds ratio] 3.24; P ≤ 0.001), alcohol abuse (EtOH) (OR 1.8; P = 0.040), dual plating (OR 1.8; P ≤ 0.001), and temporary external fixation (OR 2.07; P = 0.013) were associated with infection. In a risk-adjusted model, we found center variation in infection rates (P = 0.030)., Discussion: In a large series of patients undergoing open reduction and internal fixation of bicondylar plateau fractures, the infection rate was 7.8%. Infection was associated with DM, EtOH, combined dual plating, and temporary external fixation. Center expertise may also play a role because one center had a statistically lower rate and two trended toward higher rates after adjusting for confounders., Level of Evidence: Level IV-Therapeutic retrospective cohort study., (Copyright © 2022 by the American Academy of Orthopaedic Surgeons.)

Published
2022
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