311 results on '"Angels Ginès"'
Search Results
302. The role of endoscopic ultrasound guided fine needle aspiration (EUS-FNA) in non small cell lung cancer (NSCLC) patients: SEED-SEPD-AEG Joint Guideline
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Enrique Vázquez-Sequeiros, Fernando González-Panizo Tamargo, Ángel Barturen, Ángel Calderón, José Miguel Esteban, Gloria Fernández-Esparrach, Antonio Gimeno-García, Angels Ginés, José Lariño, Mercedes Pérez-Carreras, Rafael Romero, José Carlos Subtil, and Juan Vila
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Ultrasonografía endoscópica ,Punción con aguja fina ,Cáncer de pulmón ,Estadificación ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
Lung cancer is one of the most frequent neoplasms in our environment, and represents the first cause of cancer related death in western countries. Diagnostic and therapeutic approach to these patients may be complicated, with endoscopic ultrasound guided fine needle aspiration (EUS-FNA), classically performed by gastroenterologists, playing a very important role. As this disease is not closely related to the "digestive tract", gastroenterologists have been forced to update their knowledge on this field o adequately diagnose this significant group of patients. The recent advent of modern and promising techniques like endobronchial ultrasound guided fine needle aspiration (EBUS-FNA) have prompted new approaches for diagnosis and staging of this type of patients. In this clinical guideline, the "Sociedad Española de Endoscopia Digestiva" (SEED), "Sociedad Española de Patología Digestiva" (SEPD) and the "Asociación Española de Gastroenterología", have jointed efforts to update the existing knowledge on the field and provide their members with evidence based recommendations.
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- 2013
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- View/download PDF
303. MicroRNAs for Detection of Pancreatic Neoplasia: Biomarker Discovery by Next-generation Sequencing and Validation in 2 Independent Cohorts
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Vila-Navarro E, Vila-Casadesús M, Moreira L, Duran-Sanchon S, Sinha R, Angels Ginès, Fernández-Esparrach G, Miquel R, Cuatrecasas M, Castells A, Jj, Lozano, and Gironella M
304. Adjuvant therapy sparing in rectal cancer achieving complete response after chemoradiation
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Miriam Cuatrecasas, Òscar Reig, Antoni Castells, A. Lacy, Xabier García-Albéniz, Aarón Sosa, Angels Ginès, Iris Burkholder, Andreas Hochhaus, Mario Pagés, Rosa Miquel, Estela Pineda, J. R. Ayuso-Colella, Josep Antoni Bombí, Rosa Gallego, Iván Victoria, Salvadora Delgado, Joan Maurel, Gloria Fernández-Esparrach, Ralf Hofheinz, Verónica Pereira, Carles Conill, Luis Roberto Féliz, and Universitat de Barcelona
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Male ,Time Factors ,medicine.medical_treatment ,Biopsy ,Laparoscopic surgery ,Cirurgia laparoscòpica ,Endosonography ,Rectal Adenocarcinoma ,Prospective Studies ,Neoadjuvant therapy ,Randomized Controlled Trials as Topic ,Aged, 80 and over ,Gastroenterology ,General Medicine ,Chemoradiotherapy ,Middle Aged ,Total mesorectal excision ,Magnetic Resonance Imaging ,Neoadjuvant Therapy ,Treatment Outcome ,Estudi de casos ,Chemotherapy, Adjuvant ,Female ,Fluorouracil ,Cancer chemotherapy ,Adult ,medicine.medical_specialty ,Antimetabolites, Antineoplastic ,Radioteràpia ,Adenocarcinoma ,Unnecessary Procedures ,Disease-Free Survival ,Quimioteràpia del càncer ,Càncer colorectal ,medicine ,Adjuvant therapy ,Humans ,Cancer staging ,Mesorectal ,Aged ,Neoplasm Staging ,Radiotherapy ,business.industry ,Rectal Neoplasms ,Colorectal cancer ,Surgery ,Radiation therapy ,Spain ,Prospective Study ,Laparoscopy ,Case studies ,business - Abstract
AIM: To evaluate the long-term results of conventional chemoradiotherapy and laparoscopic mesorectal excision in rectal adenocarcinoma patients without adjuvant therapy. METHODS: Patients with biopsy-proven adenocarcinoma of the rectum staged cT3-T4 by endoscopic ultrasound or magnetic resonance imaging received neoadjuvant continuous infusion of 5-fluorouracil for five weeks and concomitant radiotherapy. Laparoscopic surgery was planned after 5-8 wk. Patients diagnosed with ypT0N0 stage cancer were not treated with adjuvant therapy according to the protocol. Patients with ypT1-2N0 or ypT3-4 or N+ were offered 5-fluorouracil-based adjuvant treatment on an individual basis. An external cohort was used as a reference for the findings. RESULTS: One hundred and seventy six patients were treated with induction chemoradiotherapy and 170 underwent total mesorectal excision. Cancer staging of ypT0N0 was achieved in 26/170 (15.3%) patients. After a median follow-up of 58.3 mo, patients with ypT0N0 had five-year disease-free and overall survival rates of 96% (95%CI: 77-99) and 100%, respectively. We provide evidence about the natural history of patients with localized rectal cancer achieving a complete response after preoperative chemoradiation. The inherent good prognosis of these patients will have implications for clinical trial design and care of patients. CONCLUSION: Withholding adjuvant chemotherapy after complete response following standard neoadjuvant chemoradiotherapy and laparoscopic mesorectal excision might be safe within an experienced multidisciplinary team.
305. Diagnosis of functional kidney failure of cirrhosis with Doppler sonography: Prognostic value of resistive index
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Vicente Arroyo, Joan Clària, Angels Ginès, Luis Anibarro, Joan Saló, Juan Rodés, Pere Ginès, Wladimiro Jiménez, and Albert Maroto
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Liver Cirrhosis ,Male ,medicine.medical_specialty ,Vasopressins ,Urology ,Renal function ,Blood Pressure ,Sensitivity and Specificity ,Plasma renin activity ,chemistry.chemical_compound ,Renal Artery ,Predictive Value of Tests ,Internal medicine ,Renin ,Ascites ,medicine ,Humans ,Renal Insufficiency ,Analysis of Variance ,Creatinine ,Kidney ,Aldosterone ,Hepatology ,business.industry ,Sodium ,Ultrasonography, Doppler ,Middle Aged ,Prognosis ,Survival Rate ,Free water clearance ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Multivariate Analysis ,Regression Analysis ,Female ,Vascular Resistance ,Liver function ,medicine.symptom ,business ,Glomerular Filtration Rate - Abstract
Time-velocity wave-form analysis of Doppler signals from small intrarenal arteries allows estimation of intrarenal arteriolar vascular resistance. Among the various indexes proposed, the resistive index is the most widely used for this estimation. To investigate whether the resistive index is useful in the diagnosis of functional kidney failure and prediction of survival in cirrhotic patients with ascites, we measured resistive index, kidney and liver function and plasma levels of renin, aldosterone and antidiuretic hormone in 10 healthy subjects, 12 patients with compensated cirrhosis and 32 patients with cirrhosis and ascites (17 with kidney failure). A total of 28 clinical and laboratory variables were analyzed for prognostic value. Resistive index was significantly increased in patients with kidney failure (0.74 +/- 0.01) compared with those in the other three groups (0.64 +/- 0.01, 0.64 +/- 0.02 and 0.67 +/- 0.01) and correlated significantly with glomerular filtration rate, arterial pressure, plasma renin activity and free water clearance in the cirrhotic patients. The sensitivity and specificity of the resistive index in detecting kidney failure in patients with ascites were 71% and 80%, respectively. Nine variables were correlated with survival in the univariate analysis, including resistive index, age, hepatomegaly, blood urea nitrogen, serum creatinine, plasma sodium concentration, glomerular filtration rate, plasma renin activity and plasma concentration of antidiuretic hormone. Multivariate analysis disclosed only three independent predictors of survival: plasma renin activity, plasma concentration of antidiuretic hormone and serum sodium concentration. In conclusion, resistive index is a sensitive method to assess intrarenal hemodynamics in patients with cirrhosis and ascites. It also has predictive value for survival in these patients.
306. Cross-reactivity of anti-Mycobacterium gordonae antibodies with the major mitochondrial autoantigens in primary biliary cirrhosis
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Angels Ginès, María Teresa Jiménez de Anta, Jordi Vila, Albert Parés, Joan Rodés, L. Vilagut, and Odette Viñas
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Male ,Biliary cirrhosis ,Immunoblotting ,Mycobacterium gordonae ,Pyruvate Dehydrogenase Complex ,Cross Reactions ,medicine.disease_cause ,Autoantigens ,Autoimmunity ,Pathogenesis ,Epitopes ,Primary biliary cirrhosis ,Antigen ,medicine ,Humans ,Autoantibodies ,Antigens, Bacterial ,Hepatology ,biology ,Liver Cirrhosis, Biliary ,Autoantibody ,Nontuberculous Mycobacteria ,Middle Aged ,medicine.disease ,biology.organism_classification ,Antibodies, Bacterial ,Mitochondria ,Immunology ,biology.protein ,Female ,Antibody - Abstract
Primary biliary cirrhosis is a chronic cholestatic liver disease associated with autoimmune disorders. Antimitochondrial autoantibodies and granulomatous portal lesions are characteristic in primary biliary cirrhosis. Since granuloma may be induced by Mycobacteria, and there is evidence implicating Mycobacteria as infectious agents capable of initiating autoimmunity, a study was performed to determine the presence of antibodies against 10 atypical Mycobacteria in 19 patients with primary biliary cirrhosis, and in 35 controls (25 patients with other chronic liver diseases and 10 healthy subjects). All primary biliary cirrhosis sera and none of the controls reacted with the extract from Mycobacterium gordonae, showing identical recognition profiles with two polypeptides of 70-65 and 55 kDa. No other reaction was found in primary biliary cirrhosis patients and in controls with the extracts from the other nine atypical Mycobacteria tested. Eluted immunoglobulins which reacted with the 70-65 and 55 kDa polypeptides from M. gordonae, bound to the mitochondrial antigens PDH-E2 and BCKDH-E2. Furthermore, when the extract from M. gordonae was tested with eluted immunoglobulins from recognized PDH-E2 and BCKDH-E2 by primary biliary cirrhosis patients, we observed both 70-65 and 55 kDa polypeptides. These data indicate that antibodies to M. gordonae, found in all primary biliary cirrhosis patients, cross-react with the major mitochondrial targets of the disease. We suggest that M. gordonae may play a potential pathogenic role in primary biliary cirrhosis.
307. Tc-99m galactosyl-neoglycoalbumin hepatic scintigraphy in fulminant hepatic failure
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J. Setoain, Javier Pavía, Angels Ginès, Montserrat Solà, Francesca Pons, M. Huguet, Merce Moragas, and Domènec Ros
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Tc-99m-galactosyl-neoglycoalbumin ,Fulminant ,chemistry.chemical_element ,Scintigraphy ,Technetium ,Fulminant hepatic failure ,Cell surface receptor ,Albumins ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Liver imaging ,medicine.diagnostic_test ,business.industry ,General Medicine ,Organotechnetium Compounds ,medicine.anatomical_structure ,chemistry ,Liver ,Hepatocyte ,Hepatic Encephalopathy ,business - Abstract
Tc-99m galactosyl-neoglycoalbumin (NGA) is a new liver imaging agent that specifically binds to a hepatocyte specific membrane receptor, the hepatic binding protein. Scintigraphy with Tc-99m NGA is a noninvasive method that provides functional images of the liver. This report deals with one case of fulminant hepatic failure in which hepatic scintigraphy with Tc-99m NGA predicted hepatic recovery before clinical and biochemical parameters, being a prognostic index in this patient.
308. Paracentesis with intravenous infusion of albumin as compared with peritoneovenous shunting in cirrhosis with refractory ascites
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Joan Rodés, Pere Ginès, Angels Ginès, Vicente Arroyo, Fernando Casafont, Rosa Maria Morillas, Rafael Esteban, Ramon Planas, Julià Panés, Antoni Rimola, Joan Manuel Salmerón, Victor Vargas, L Viladomiu, and Melchor Hoyos
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Liver Cirrhosis ,Male ,Peritoneovenous Shunt ,medicine.medical_specialty ,Cirrhosis ,medicine.medical_treatment ,Punctures ,Suction ,Patient Readmission ,law.invention ,Randomized controlled trial ,Recurrence ,law ,Albumins ,Ascites ,medicine ,Paracentesis ,Humans ,Infusions, Intravenous ,medicine.diagnostic_test ,business.industry ,Albumin ,General Medicine ,Length of Stay ,Middle Aged ,medicine.disease ,Surgery ,Peritoneovenous shunt ,Female ,medicine.symptom ,Diuretic ,business ,Shunt (electrical) ,Follow-Up Studies - Abstract
There is no satisfactory treatment for refractory ascites in patients with cirrhosis. Both peritoneovenous shunts and paracentesis have been used, but there is uncertainty about their relative merits.We studied 89 patients with cirrhosis and refractory ascites who were randomly assigned to receive either repeated large-volume paracentesis plus intravenous albumin or a LeVeen peritoneovenous shunt. Patients in the paracentesis group in whom recurrent tense ascites developed during follow-up were treated with paracentesis, and those in the peritoneovenous-shunt group with diuretic agents or by the insertion of a new shunt if there was shunt obstruction.During the first hospitalization, ascites was removed in all 41 patients in the paracentesis group and in 44 of the 48 patients in the peritoneovenous-shunt group. The mean (+/- SD) duration of hospitalization in the two groups was 11 +/- 5 and 19 +/- 9 days, respectively (P less than 0.01). There were no significant differences in the number of patients who had complications or died. During follow-up, 37 patients in each group were hospitalized again. In the paracentesis group, the number of rehospitalizations for any reason (174 vs. 97 in the peritoneovenous-shunt group) or for ascites (125 vs. 38) was significantly higher, and the median time to a first readmission for any reason (1 +/- 1 vs. 2 +/- 2 months) or for ascites (2 +/- 2 vs. 8 +/- 17 months) was significantly shorter than in the peritoneovenous-shunt group. The total times in the hospital during follow-up, however, were similar in the two groups (48 +/- 49 and 44 +/- 39 days, respectively). Three patients had obstructions of their peritoneovenous shunts during their first hospitalizations, and 15 patients had a total of 20 obstructions during follow-up. Survival was similar in both groups.The LeVeen shunt and paracentesis are equally effective in relieving refractory ascites. The former may provide better long-term control of ascites, but shunt occlusion is common and survival is not improved.
309. Incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites
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Luis Inglada, Joan Clària, Antoni Rimola, Angels Ginès, Miquel Navasa, Joan Rodés, Joan Saló, Pere Ginès, Angels Escorsell, Wladimiro Jiménez, and Vicente Arroyo
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Adult ,Liver Cirrhosis ,Male ,medicine.medical_specialty ,Cirrhosis ,Hepatorenal Syndrome ,Renal function ,Gastroenterology ,Plasma renin activity ,chemistry.chemical_compound ,Hepatorenal syndrome ,Internal medicine ,Ascites ,Renin ,medicine ,Humans ,Aged ,Aged, 80 and over ,Creatinine ,Hepatology ,business.industry ,Sodium ,Middle Aged ,medicine.disease ,Prognosis ,Free water clearance ,Survival Rate ,Endocrinology ,chemistry ,Female ,medicine.symptom ,Terlipressin ,business ,medicine.drug - Abstract
Background: The aim of the study was to investigate the incidence, predictive factors, and prognosis of the hepatorenal syndrome in cirrhosis with ascites. Methods: The study is a follow-up investigation in 234 nonazotemic patients with cirrhosis and ascites. Thirty-nine variables obtained at inclusion were analyzed as possible predictors of hepatorenal syndrome occurrence (Kaplan-Meier method, Mantel-Cox test, and step-wise Cox regression procedure). Results: The probability of hepatorenal syndrome occurrence was 18% at 1 year and 39% at 5 years. Sixteen variables had predictive value for hepatorenal syndrome occurrence in the univariate analysis: history of ascites, hepatomegaly, nutritional status, blood urea nitrogen level, serum creatinine concentration, serum sodium and potassium concentration, serum and urine osmolality, urinary sodium excretion, free water clearance after a water load, glomerular filtration rate, arterial pressure, plasma renin activity, plasma norepinephrine concentration, and esophageal varices. Neither etiology (alcoholic vs. nonalcoholic) nor the Child-Pugh score had predictive value. A multivariate analysis disclosed only three independent predictors of hepatorenal syndrome occurrence: low serum sodium concentration, high plasma renin activity, and absence of hepatomegaly. Conclusions: The hepatorenal syndrome is a relatively frequent complication in cirrhotic patients with ascites that is associated with an extremely short survival. Liver size, plasma renin activity, and serum sodium concentration are predictors of hepatorenal syndrome occurrence in these patients.
310. Uptake of technetium-99m DISIDA by bone metastasis from a hepatoma
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Angels Ginès, Ana M. Catafau, Xavier Calvet, J Setoain, Jordi Bruix, Francisco Lomeña, R Herranz, and F. Pons
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Male ,Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,chemistry.chemical_element ,Bone Neoplasms ,Technetium Tc 99m Disofenin ,Scintigraphy ,Technetium ,Metastasis ,Organometallic Compounds ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Radionuclide Imaging ,Lung ,medicine.diagnostic_test ,business.industry ,Imino Acids ,Liver Neoplasms ,Bone metastasis ,General Medicine ,Middle Aged ,medicine.disease ,digestive system diseases ,medicine.anatomical_structure ,chemistry ,Hepatocellular carcinoma ,business ,Technetium-99m - Abstract
Uptake of Tc-99m DISIDA in a bone metastasis from a hepatoma located at the humeral head is reported. Previous literature has only shown extrahepatic uptake of hepatobiliary agents in cases of lung metastases from hepatocellular carcinoma. The use of imaging with biliary tracers can increase the diagnostic specificity when bone metastases from hepatoma are suspected.
311. Endorectal ultrasound (EUS) and cancer risk in ND: Yag laser treated rectal villous adenoma
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M, Angels Ginès, B, Napoléon, F, Descos, B, Pujol, O, Keriven-Souquet, and JC, Souquet
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- 1996
- Full Text
- View/download PDF
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