301. Significance of measuring S100A12 and sRAGE in the serum of sepsis patients with postoperative acute lung injury.
- Author
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Kikkawa T, Sato N, Kojika M, Takahashi G, Aoki K, Hoshikawa K, Akitomi S, Shozushima T, Suzuki K, Wakabayashi G, and Endo S
- Subjects
- Acute Lung Injury etiology, Acute Lung Injury mortality, Aged, Aged, 80 and over, Biomarkers blood, Cohort Studies, Critical Illness, Female, Follow-Up Studies, Humans, Male, Middle Aged, Peritonitis complications, Peritonitis mortality, Peritonitis surgery, Postoperative Complications blood, Postoperative Complications mortality, Receptor for Advanced Glycation End Products, Retrospective Studies, Risk Assessment, S100A12 Protein, Sensitivity and Specificity, Sepsis etiology, Sepsis mortality, Statistics, Nonparametric, Survival Analysis, Treatment Outcome, Acute Lung Injury blood, Receptors, Immunologic blood, S100 Proteins blood, Sepsis blood, Sepsis surgery
- Abstract
Background: There is a report that S100A12 is useful as an early marker of acute lung injury (ALI). The purpose of this study was to determine whether S100A12 or sRAGE is useful as a marker during the development of ALI in postoperative sepsis patients., Methods: The subjects were patients who underwent emergency surgery because of sepsis secondary to perforation of the lower gastrointestinal tract. We conducted a retrospective study comparing 2 groups of patients: a group of 9 patients who developed postoperative ALI, the ALI(+) group, and a group of 8 patients who did not develop postoperative ALI, the ALI(-) group. Their blood S100A12, sRAGE, IFN-gamma, WBC count, and CRP values were measured immediately after surgery and on postoperative day 1 (D1)., Results: The changes in S100A12 showed significantly higher values immediately postoperatively in the ALI(+) group (p < 0.05). The sRAGE values immediately postoperatively were similar, but on D1, they were significantly higher in the ALI(-) group (p < 0.05)., Conclusions: S100A12 increases in the early stage of development of ALI. sRAGE production increases in patients who do not develop ALI., (Copyright 2010 S. Karger AG, Basel.)
- Published
- 2010
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