Descriptor: "[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging" - Searchworks@Jio Institute Digital Library Search Results

Your search keyword '"[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging"' showing total 364 results

Start Over Descriptor "[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging"

364 results on '"[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging"'

301. Rapid-Clearance Iron Nanoparticles for Inflammation Imaging in Atherosclerotic Plaque: Initial Experience in Animal Model

Author: Sigovan, M., Boussel, L., Sulaiman, A., Sappey-Marinier, D., Alsaid, H., Desbleds-Mansard, C., Ibarrola, D., Gamondès, D., Corot, C., Lancelot, E., Raynaud, J. S., Vives, V., LaclÉ, D E Re C., Violas, X., Douek, P., Canet-Soulas, E., Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [ SDV.IB.MN ] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: article; International audience
Published: 2009

302. Design of a High Performances Small Animal PET System With Axial Oriented Crystals and DOI Capability

Author: David Brasse, D. Huss, S. Salvador, Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Nuclear and High Energy Physics, Photomultiplier, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Photodetector, high throughput, 01 natural sciences, Lyso, Detection efficiency, 030218 nuclear medicine & medical imaging, Crystal, 03 medical and health sciences, 0302 clinical medicine, Optics, small animal imaging, 0103 physical sciences, Figure of merit, positron emission tomography (PET), Electrical and Electronic Engineering, Image resolution, spatial resolution, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Physics, 010308 nuclear & particles physics, business.industry, Detector, Solid angle, Nuclear Energy and Engineering, business
Abstract: In most Positron Emission Tomography (PET) systems dedicated to small animal imaging, the geometry of the detector module is based on a block structure where the crystal elements are coupled to a reduced number of photomultiplier tubes (PMT). In this configuration, the spatial resolution and the detection efficiency depend on the crystal dimensions and thus there is a correlation between these two figures of merit. In this paper, we present a method already used by Ter-Pogossian in the 1970s allowing the spatial resolution and the detection efficiency to be independent of each other. The crystals are oriented in the axial direction readout on both sides by individual photodetector channels. The spatial resolution in the transverse plane is driven by the crystal section and the spatial resolution in the axial direction is proportional to the contrast of the light collected on both sides of the crystal. The detection efficiency depends on the number of radial crystal layers and the geometry of the system. With the perfect knowledge of the interaction depth, the inner diameter of the PET system can be reduced to a minimum value leading to an increase in detection efficiency. We investigate two particular geometries dedicated to mouse and whole purpose studies and based on the same detection module. Each module consists on a matrix of 32 $,times,$24 LYSO:Ce crystals of 1.5 mm$,times,$1.5 mm$,times,$25 mm each read at both ends by a Photonis Corp multi-channel plate photodetector. The surface treatment is optimized to reach a volumetric spatial resolution of 1 mm$^{3}$. The detection efficiency of each system is evaluated using Monte Carlo simulation. The mouse and whole purpose systems a- - re based on 4 and 6 modules with an inner diameter of 61.2 mm and 103.2 mm where the axial extent is 25 mm leading to a detection efficiency of 18% and 13%, respectively. This geometrical configuration leads to a detection efficiency close to the system solid angle with a volumetric spatial resolution of 1 mm$^{3}$ .
Published: 2009

303. Physically-Constrained Diffeomorphic Demons for the Estimation of 3D Myocardium Strain from Cine-MRI

Author: Julie Blanc, Hervé Delingette, Tommaso Mansi, Nicholas Ayache, Younes Boudjemline, Maxime Sermesant, Jean-Marc Peyrat, Analysis and Simulation of Biomedical Images (ASCLEPIOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Service de cardiologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), and Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP]
Subjects: Cardiac function curve, [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Computer science, 0206 medical engineering, Image registration, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 02 engineering and technology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Quantitative assessment, Computer vision, cardiovascular diseases, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS, Ground truth, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, business.industry, Heart motion, Healthy subjects, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 020601 biomedical engineering, Cine mri, cardiovascular system, Diffeomorphism, Artificial intelligence, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: Analysing heart motion provides crucial insights on the condition of the cardiac function. Tagged-MRI and 2D-strain ultrasound enable quantitative assessment of the myocardium strain. But estimating 3D myocardium strain from cine-MRI remains attractive: cine-MRI is widely available and it yields detailed 3D+t anatomical images. This paper presents an image-based method to estimate myocardium strain from clinical short-axis cine-MRI. To recover non-apparent cardiac motions, we improve the diffeomorphic demons, a non-linear registration algorithm, by adding two physical constraints. First, myocardium near-incompressibility is ensured by constraining the deformations to be divergence free. Second, myocardium elasticity is modelled using smooth vector filters. The proposed physically-constrained demons are compared with the diffeomorphic demons and evaluated in a healthy subject against tagged MRI. The method is also tested on a patient with congenital pulmonary valve regurgitations and compared with 2D-strain measurements. In both cases, obtained results correlate well with ground truth. This method may become a useful tool for cardiac function evaluation.
Published: 2009

304. Nouvelle tomographie Compton

Author: Nguyen, M. K., Driol, C., Truong, T. T., Paindavoine, M., Dominique Ginhac, Nguyen, Mai K., Equipes Traitement de l'Information et Systèmes ( ETIS ), Ecole Nationale Supérieure de l'Electronique et de ses Applications ( ENSEA ) -Université de Cergy Pontoise ( UCP ), Université Paris-Seine-Université Paris-Seine-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Physique Théorique et Modélisation ( LPTM ), Université de Cergy Pontoise ( UCP ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Equipes Traitement de l'Information et Systèmes (ETIS - UMR 8051), Ecole Nationale Supérieure de l'Electronique et de ses Applications (ENSEA)-Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Laboratoire de Physique Théorique et Modélisation (LPTM - UMR 8089), Centre National de la Recherche Scientifique (CNRS)-CY Cergy Paris Université (CY), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, and HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement
Subjects: [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing
Abstract: International audience
Published: 2009

305. Virtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model

Author: Mansi , Tommaso, André , Barbara, Lynch , Michael, Sermesant , Maxime, Delingette , Hervé, Boudjemline , Younes, Ayache , Nicholas, Analysis and Simulation of Biomedical Images (ASCLEPIOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Mauna Kea Technologies, Service de cardiologie pédiatrique [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Magnenat-Thalmann, Nadia and Zhang, Jian J. and Feng, David D., Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], and Magnenat-Thalmann, Nadia and Zhang, Jian J. and Feng, David D.
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; no abstract
Published: 2009

306. Optimization of crystal lengh to improve the depth of interaction spatial resolution in PET imaging

Author: Salvador, S., Wurtz, J., Huss, D., Brasse, D., Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Heyd, Yvette, Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2008

307. A New Intraoperative Gamma Camera for the Sentinel Lymph Node Procedure in Breast Cancer

Author: Mathelin , C., Salvador , S., Bekaert , V., Croce , S., Andriamisandratsoa , N., LiÉgeois , P., Prados , E., Guyonnet , J.L., Grucker , D., Brasse , D., Service de gynecologie-obstetrique (SERVICE DE GYNECOLOGIE-OBSTETRIQUE), Hopital Civil, Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Service de gynecologie-obstetrique ( SERVICE DE GYNECOLOGIE-OBSTETRIQUE ), Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: body regions, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.CAN]Life Sciences [q-bio]/Cancer, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Abstract: International audience; This study aimed at evaluating the performance of an intraoperative gamma camera, named CarolIReS, to detect axillary drainage and to assess the removal of sentinel lymph nodes (SLN) in breast surgery. Patients and Methods: SLN biopsy was performed on 25 patients and the CarolIReS camera was used preoperatively to localize SLNs. During surgery, individual removal of SLNs was performed using a gamma probe and their activity was measured with a gamma ray counter. At the end of surgery, the CarolIReS camera was used again to check the quality of surgery which was followed by surgical excision for remaining SLNs. Results: The detection efficiency of the CarolIReS camera was 2.2 cps/kBq for 99mTc activity in SLNs. In one case, it allowed the detection of a residual SLN with a low activity (0.5 kBq) which was massively metastatic. Conclusion: Intraoperative cameras could be used to improve the efficiency of the SLN procedure
Published: 2008

308. Utilisation du modèle de personnalité à cinq facteurs (FFM) dans l'évaluation des troubles de la personnalité du DSM-IV

Author: Joshua D. Miller, Jean-Pierre Rolland, Donald R. Lynam, F. De Fruyt, A. Pham-Scottez, B. De Clercq, Troubles du comportement alimentaire de l'adolescent (UMR_S 669), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Clinique des Maladies Mentales et de l'Encéphale, Hôpital Sainte-Anne, Centre de Recherche sur le Sport et le Mouvement (CeRSM), Université Paris Nanterre (UPN), Université Paris-Sud - Paris 11 (UP11)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Troubles du comportement alimentaire de l'adolescent ( UMR_S 669 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Sud - Paris 11 ( UP11 ), Centre de Recherche sur le Sport et le Mouvement ( CeRSM ), and Université Paris Nanterre ( UPN )
Subjects: DSM-IV Axis II, 050103 clinical psychology, Facettes, [ SDV.MHEP.PHY ] Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, assessment, 05 social sciences, 050109 social psychology, FFM counts, Analyse du Mouvement en Biomécanique Physiologie et Imagerie, Five-Factor Model, Psychiatry and Mental health, DSM-IV Axe II, Computer-Assisted, Troubles de la personnalité, Arts and Humanities (miscellaneous), Évaluation, [SDV.MHEP.PHY]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], 0501 psychology and cognitive sciences, Personality disorders, [PHYS.MECA.BIOM]Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph], Modèle de personnalité à cinq facteurs, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Applied Psychology, [ PHYS.MECA.BIOM ] Physics [physics]/Mechanics [physics]/Biomechanics [physics.med-ph]
Abstract: National audience; Un ensemble de recherches récentes suggèrent que les troubles de la personnalité décrits par le DSM-IV peuvent être évalués à partir d’un modèle général de description de la personnalité : le modèle à cinq facteurs (five-factor model: FFM). Dans cet article, nous présentons une méthode permettant de calculer des scores pour les différents troubles de la personnalité à partir du FFM. Sur la base de profils de personnalité prototypiques fournis par des experts pour chacun des troubles décrits par le DSM-IV, il est possible d’identifier, puis d’additionner les scores obtenus pour les traits de personnalité caractéristiques de chacun des troubles et d’obtenir un score de type dimensionnel pour chacun d’eux. Les scores ainsi obtenus pour les différents troubles de la personnalité sont comparés (corrélations et efficacité diagnostique) à des évaluations plus explicites et directes de symptômes décrits par le DSM-IV, réalisées sur deux échantillons de patients. Pour la plupart des troubles de la personnalité, à l’exception des troubles de la personnalité obsessionnelle–compulsive et histrionique, la validité convergente, la spécificité, la sensibilité et le potentiel de prédictivité négative (NPP) varient de « modérés » à « satisfaisants ». La validité discriminante, qui permet l’examen de la comorbidité entre les différents troubles, est équivalente à celle obtenue par des méthodes d’évaluation explicites et directes. Nous envisageons finalement les avantages de cette méthode en pratique clinique : facilité de l’évaluation de la personnalité, facilité de la cotation, existence de données de référence normatives.
Published: 2008

309. Filtering, segmentation and region classification by hyperspectral mathematical morphology of DCE-MRI series for angiogenesis imaging

Author: Daniel Balvay, Jesús Angulo, Dominique Jeulin, Charles-André Cuénod, Guillaume Noyel, Centre de Morphologie Mathématique (CMM), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University (PSL), LRI-EA4062, Université Paris Descartes - Paris 5 (UPD5), Service de radiologie (AP-HP - HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), MINES ParisTech - École nationale supérieure des mines de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Morphologie Mathématique ( CMM ), MINES ParisTech - École nationale supérieure des mines de Paris-PSL Research University ( PSL ), Université Paris Descartes - Paris 5 ( UPD5 ), Assistance publique - Hôpitaux de Paris (AP-HP), and MINES ParisTech - École nationale supérieure des mines de Paris - PSL Research University (PSL)
Subjects: [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Normalization (image processing), ACM : I.4.6, tumours, 02 engineering and technology, ACM : I.: Computing Methodologies/I.4: IMAGE PROCESSING AND COMPUTER VISION, medical image processing, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 030218 nuclear medicine & medical imaging, ACM : I.5, 0302 clinical medicine, ACM : I.4, ACM : I.: Computing Methodologies/I.5: PATTERN RECOGNITION, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, 0202 electrical engineering, electronic engineering, information engineering, Segmentation, Computer vision, image segmentation, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Mathematics, [MATH.TR-IMG] Mathematics [math]/domain_math.tr-img, ACM: I.: Computing Methodologies/I.5: PATTERN RECOGNITION, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, Contextual image classification, Hyperspectral imaging, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], filtering theory, 020201 artificial intelligence & image processing, hyperspectral images, probability, angiogenesis imaging, biomedical MRI, [SDV.CAN]Life Sciences [q-bio]/Cancer, Mathematical morphology, Edge detection, blood vessels, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, [INFO.INFO-TI] Computer Science [cs]/Image Processing, Histogram, Machine learning, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, cancer, image enhancement, ACM : I.: Computing Methodologies/I.4: IMAGE PROCESSING AND COMPUTER VISION/I.4.6: Segmentation, edge detection, Dynamic Contrast Enhanced MRI, ACM: I.: Computing Methodologies/I.4: IMAGE PROCESSING AND COMPUTER VISION, business.industry, segmentation, Pattern recognition, Image segmentation, [MATH.APPL] Mathematics [math]/domain_math.appl, ACM: I.: Computing Methodologies/I.4: IMAGE PROCESSING AND COMPUTER VISION/I.4.6: Segmentation, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Computer Science::Computer Vision and Pattern Recognition, Mathematical Morphology, Artificial intelligence, Multivariate images, business, image classification
Abstract: ISBN : 978-1-4244-2002-5; International audience; Segmenting dynamic contrast enhanced-MRI series of small animal, which are intrinsically noisy and low contrasted images with low resolution, is the aim of this paper. To do this, a segmentation method taking into account the temporal (spectral) and spatial information is presented on several series. The idea is to start from a temporal classification, and to build a probability density function of contours conditionally to this classification. Then, this function is segmented to find potentially tumorous areas. The method is presented on several series after a range normalization histogram in order to compare the series.
Published: 2008

310. Comparison of T1 and T2 Metabolite Relaxation Times in Glioma and Normal Brain at 3T

Author: Li, Y., Srinivasan, R., Ratiney, H., Lu, Y., Chang, S. M., Nelson, S. J., Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), and Laboratoire Creatis, Compte Général
Subjects: [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.IB]Life Sciences [q-bio]/Bioengineering, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: article
Published: 2008

311. Vecteurs de Stokes Retrodiffuses par des Milieux diffusants : Estimation du Facteur d'Anisotropie et du Coefficient de Diffusion Reduit

Author: E. Perrin, Raphaël Sablong, Julie Falconet, Hervé Saint-Jalmes, Franck Jaillon, Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, Biomedical Engineering, Biophysics, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: Resume La caracterisation optique des tissus biologiques est un enjeu important pour le diagnostic medical et plus particulierement pour la detection precoce de tissus cancereux. Les methodes de caracterisation permettent generalement d’estimer le coefficient d’absorption μa et le coefficient de diffusion reduit μ′s. Quelques methodes permettent egalement d’estimer le facteur d’anisotropie g, mais la plupart sont invasives. Nous proposons une nouvelle methode non invasive permettant l’estimation de g et de μ′s en lumiere polarisee. Elle repose sur l’analyse de Fourier de l’element Q du vecteur de Stokes retrodiffuse par un milieu turbide. Les images de ces elements Q presentent des motifs specifiques dependants de g, alors que la taille de ces motifs depend plutot de μ′s. L’utilisation de descripteurs de Fourier (DF) sur des donnees simulees et experimentales met en valeur les informations geometriques recherchees dans l’element Q, qui permettent de determiner le facteur d’anisotropie et le coefficient de diffusion reduit.
Published: 2008

312. Modified EKG-triggered black-blood turbo spin-echo technique to improve T1-weighting in contrast-enhanced MRI of atherosclerotic carotid arteries

Author: Boussel, L., Herigault, G., Sigovan, M., Loffroy, R., Emmanuelle Canet Soulas, Douek, P., Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Laboratoire Creatis, Compte Général
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, [ SDV.MHEP.CSC ] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [INFO.INFO-MO] Computer Science [cs]/Modeling and Simulation, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: article
Published: 2008

313. A framework for evaluating the impact of compression on registration algorithms without gold standard

Author: Xavier Pennec, Johan Montagnat, Tristan Glatard, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe MODALIS, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Analysis and Simulation of Biomedical Images (ASCLEPIOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), This work was funded by the AGIR French research program 'ACI Masse de données' http://www.aci-agir.org., Grid'5000, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), Scalable and Pervasive softwARe and Knowledge Systems ( SPARKS ), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis ( I3S ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ) -Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis ( I3S ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), and Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria )
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Computer science, Image registration, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Data_CODINGANDINFORMATIONTHEORY, 02 engineering and technology, Lossy compression, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, [ INFO.INFO-DC ] Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Compression (functional analysis), [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, 0202 electrical engineering, electronic engineering, information engineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Feature (computer vision), 020201 artificial intelligence & image processing, [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithm, Data compression
Abstract: International audience; The impact of lossy compression has often been discussed in the medical area. In this study, an evaluation of the impact of lossy compression on the performance of rigid registration algorithms for medical images is proposed. The robustness, repeatability and accuracy of these algorithms is estimated through a statistical procedure for each compression ratio. Results are obtained thanks to a grid technology handling the computation cost of the method. Experiments reveal that the impact of compression is quite negligible below a significant compression ratio if the registration algorithm has a good multi-scale handling. Beyond this threshold, feature-based methods are highly penalized.
Published: 2008

314. AN OPERATIVE GAMMA CAMERA DEDICATED TO THE OPTIMIZATION OF SENTINEL LYMPH NODE PROCEDURE IN BREAST CANCER SURGERY

Author: Francis , Z., Bekaert , V., Salvador , S., Brasse , D., Huss , D., Mathelin , C., Heyd, Yvette, Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Service de gynécologie–obstétrique, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.CAN]Life Sciences [q-bio]/Cancer, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS, [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Abstract: International audience
Published: 2008

315. Optimization of sentinel lymph node biopsy in breast cancer using an operative gamma camera

Author: S. Salvador, Carole Mathelin, Norosoa Andriamisandratsoa, Jean-Louis Guyonnet, Sabrina Croce, D. Huss, Service de gynécologie–obstétrique, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Département Recherches Subatomiques ( DRS-IPHC ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS ), Département Recherches Subatomiques (DRS-IPHC), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)
Subjects: medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Sentinel lymph node, lcsh:Surgery, [SDV.CAN]Life Sciences [q-bio]/Cancer, Case Report, Tumor Staging, lcsh:RC254-282, 030218 nuclear medicine & medical imaging, law.invention, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Randomized controlled trial, Surgical oncology, law, Biopsy, medicine, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Gamma camera, medicine.diagnostic_test, business.industry, lcsh:RD1-811, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, 3. Good health, Surgery, Oncology, 030220 oncology & carcinogenesis, Radiology, business
Abstract: Background Sentinel lymph node (SLN) procedure is now a widely accepted method of LN staging in selected invasive breast cancers (unifocal, size ≤ 2 cm, clinically N0, without previous treatment). Complete axillary clearance is no longer needed if the SLN is negative. However, the oncological safety of this procedure remains to be addressed in randomized clinical trials. One main pitfall is the failure to visualize SLN, resulting in incorrect tumor staging, leading to suboptimal treatment or axillary recurrence. Operative gamma cameras have therefore been developed to optimize the SLN visualization and the quality control of surgery. Case presentation A 44-year-old female patient with a 14-mm infiltrative ductal carcinoma underwent the SLN procedure. An operative gamma camera was used during and after the surgery. The conventional lymphoscintigraphy showed only one SLN, which was also detected by the operative gamma camera, then removed and measured (9.6 kBq). It was analyzed by frozen sections, showing no cancer cells. During this analysis, the exploration of the axillary area with the operative gamma camera enabled the identification of a second SLN with low activity (0.5 kBq) that conventional lymphoscintigraphy, surgical probe and blue staining had failed to visualize. Histological examination revealed a macrometastasis. Axillary clearance was then performed, followed by a postoperative image proving that no SLN remained. Therefore, the use of the operative gamma camera prevented an under-estimation of staging which would have resulted in a suboptimal treatment for this patient. Conclusion This case report illustrates that an efficient operative gamma camera may be able to decrease the risk of false negative rate of the SLN procedure, and could be an additional tool to control the quality of the surgery. Trial Registration ClinicalTrials.gov Identifier: NCT00357487
Published: 2007

316. Uncinate fasciculus fiber tracking in mesial temporal lobe epilepsy. Initial findings

Author: D. Le Bihan, Catherine Oppenheim, J.-F. Mangin, Y. Cointepas, F. Semah, Sebastian Rodrigo, C. Poupon, Narly Golestani, Francine Chassoux, Jean-François Meder, service de neuroradiologie [Paris], Hôpital Sainte-Anne, Commissariat à l'Energie Atomique, Direction des Sciences du Vivant, Département de Recherche Médicale, Service Hospitalier Frédéric Joliot, Service de Neurochirurgie, Hôpital Saint-Anne, Institut d'imagerie neurofonctionnelle ( IIN ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -ENST-Assistance publique - Hôpitaux de Paris (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -École des hautes études en sciences sociales ( EHESS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Traitement et Communication de l'Information ( LTCI ), Télécom ParisTech-Institut Mines-Télécom [Paris]-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Imagerie et de Spectroscopie ( LRMN ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Service Hospitalier Frédéric Joliot ( SHFJ ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Human Brain Research Center [Kyoto] ( HBRC ), Kyoto University [Kyoto], Service NEUROSPIN ( NEUROSPIN ), National Institutes of Health [Bethesda] ( NIH ), IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), DIMF, Université Paris Descartes - Paris 5 ( UPD5 ) -Centre Hospitalier Sainte-Anne, Service de neuroradiologie [Paris], Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut d'imagerie neurofonctionnelle (IIN), Université Paris-Sud - Paris 11 (UP11)-Université Pierre et Marie Curie - Paris 6 (UPMC)-École des hautes études en sciences sociales (EHESS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Ecole Nationale Supérieure des Télécommunications (ENST)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Traitement et Communication de l'Information (LTCI), Télécom ParisTech-Institut Mines-Télécom [Paris] (IMT)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Imagerie et de Spectroscopie (LRMN), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Human Brain Research Center [Kyoto] (HBRC), Kyoto University, Service NEUROSPIN (NEUROSPIN), National Institutes of Health [Bethesda] (NIH), IFR de Neuroimagerie Fonctionnelle (IFR 49), Université Paris Descartes - Paris 5 (UPD5)-Centre Hospitalier Sainte-Anne, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure des Télécommunications (ENST)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École des hautes études en sciences sociales (EHESS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Santé et de la Recherche Médicale (INSERM)-ENST-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École des hautes études en sciences sociales (EHESS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, MESH: Hippocampus, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Frontal Lobe, MESH : Hippocampus, Hippocampus, Nerve Fibers, Myelinated, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, MESH : Neural Pathways, Reference Values, Neural Pathways, Image Processing, Computer-Assisted, MESH : Anisotropy, MESH : Female, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Energy Metabolism, MESH: Reference Values, General Medicine, Human brain, Anatomy, MESH : Adult, MESH : Diffusion Magnetic Resonance Imaging, MESH: Image Processing, Computer-Assisted, Temporal Lobe, Frontal Lobe, MESH: Nerve Fibers, Myelinated, medicine.anatomical_structure, MESH: Epilepsy, Temporal Lobe, MESH : Imaging, Three-Dimensional, Female, Radiology, MESH : Image Processing, Computer-Assisted, Adult, medicine.medical_specialty, Adolescent, MESH : Male, Uncinate fasciculus, MESH: Imaging, Three-Dimensional, MESH: Diffusion Magnetic Resonance Imaging, MESH : Dominance, Cerebral, Insular cortex, MESH : Reference Values, behavioral disciplines and activities, Temporal lobe, White matter, 03 medical and health sciences, Imaging, Three-Dimensional, MESH : Adolescent, MESH : Nerve Fibers, Myelinated, Fractional anisotropy, medicine, Humans, MESH: Temporal Lobe, MESH : Frontal Lobe, Radiology, Nuclear Medicine and imaging, Ictal, Dominance, Cerebral, MESH : Temporal Lobe, MESH: Adolescent, Hippocampal sclerosis, Sclerosis, MESH: Humans, business.industry, MESH: Neural Pathways, MESH : Humans, MESH: Adult, MESH: Dominance, Cerebral, medicine.disease, MESH: Male, MESH : Sclerosis, MESH : Energy Metabolism, MESH : Epilepsy, Temporal Lobe, Diffusion Magnetic Resonance Imaging, Epilepsy, Temporal Lobe, nervous system, MESH: Anisotropy, Anisotropy, MESH: Sclerosis, business, Energy Metabolism, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; In temporal lobe epilepsy (TLE) due to hippocampal sclerosis (HS), ictal discharge spread to the frontal and insulo-perisylvian cortex is commonly observed. The implication of white matter pathways in this propagation has not been investigated. We compared diffusion tensor imaging (DTI) measurements along the uncinate fasciculus (UF), a major tract connecting the frontal and temporal lobes, in patients and controls. Ten right-handed patients referred for intractable TLE due to a right HS were investigated on a 1.5-T MR scanner including a DTI sequence. All patients had interictal fluorodeoxyglucose PET showing an ipsilateral temporal hypometabolism associated with insular and frontal or perisylvian hypometabolism. The controls consisted of ten right-handed healthy subjects. UF fiber tracking was performed, and its fractional anisotropy (FA) values were compared between patients and controls, separately for the right and left UF. The left-minus-right FA UF asymmetry index was computed to test for intergroup differences. Asymmetries were found in the control group with right-greater-than-left FA. This asymmetrical pattern was lost in the patient group. Right FA values were lower in patients with right HS versus controls. Although preliminary, these findings may be related to the preferential pathway of seizure spread from the mesial temporal lobe to frontal and insulo-perisylvian areas.
Published: 2007

317. Merging overlapping orchestrations: an application to the Bronze Standard medical application

Author: Mireille Blay-Fornarino, Johan Montagnat, C. Nemo-Cailliau, Tristan Glatard, Laboratoire d'Informatique, Signaux, et Systèmes de Sophia-Antipolis (I3S) / Equipe MODALIS, Scalable and Pervasive softwARe and Knowledge Systems (Laboratoire I3S - SPARKS), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis (I3S), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Analysis and Simulation of Biomedical Images (ASCLEPIOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), IEEE Computer Engineering, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA)-Université Nice Sophia Antipolis (... - 2019) (UNS), Scalable and Pervasive softwARe and Knowledge Systems ( SPARKS ), Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis ( I3S ), Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Nice Sophia Antipolis ( UNS ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ) -Laboratoire d'Informatique, Signaux, et Systèmes de Sophia Antipolis ( I3S ), Université Côte d'Azur ( UCA ) -Université Côte d'Azur ( UCA ) -Centre National de la Recherche Scientifique ( CNRS ), Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), and Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria )
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, Service (systems architecture), [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, Computer science, Process (engineering), [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 02 engineering and technology, computer.software_genre, Set (abstract data type), [ INFO.INFO-DC ] Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, 0202 electrical engineering, electronic engineering, information engineering, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Orchestration (computing), [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, business.industry, 020207 software engineering, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 020201 artificial intelligence & image processing, Data mining, Web service, [INFO.INFO-DC]Computer Science [cs]/Distributed, Parallel, and Cluster Computing [cs.DC], Software engineering, business, computer, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: International audience; Merging orchestrations is a crucial issue in the development process of service-based applications. However, merging orchestrations with overlaps is a manual and tedious process today. In this paper, we present a case-study on the Bronze-Standard, a medical imaging application built from Web-Service based orchestrations. We introduce the OMSM, an orchestration model supporting merging, that we designed to assist this process. Through a detailed analysis of the use-case, we show how our model helps the devel- oper to obtain a proper composition of the application. There is still room for generalizing the approach to a broader set of orchestrations as discussed.
Published: 2007

318. Analysis of the fiber architecture of the heart by quantitative polarized light microscopy. Accuracy, limitations and contribution to the study of the fiber architecture of the ventricles during fetal and neonatal life

Author: Ayman Mourad, Gabrielle Michalowicz, Pierre-Simon Jouk, Annie Raoult, Yves Usson, Denis Caillerie, Vuk Milisic, RFMQ, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Equations aux Dérivées Partielles (EDP), Laboratoire Jean Kuntzmann (LJK), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), Laboratoire sols, solides, structures - risques [Grenoble] (3SR), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] ( TIMC-IMAG ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut polytechnique de Grenoble - Grenoble Institute of Technology ( Grenoble INP ) -IMAG-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Equations aux Dérivées Partielles ( EDP ), Laboratoire Jean Kuntzmann ( LJK ), Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ) -Université Pierre Mendès France - Grenoble 2 ( UPMF ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire sols, solides, structures - risques [Grenoble] ( 3S-R ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National Polytechnique de Grenoble ( INPG ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Grenoble Alpes ( UGA ), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Joseph Fourier - Grenoble 1 (UJF)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Centre National de la Recherche Scientifique (CNRS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Joseph Fourier - Grenoble 1 (UJF)-Université Pierre Mendès France - Grenoble 2 (UPMF)
Subjects: MESH: Neoplasm Proteins, MESH : Transcription Factors, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : DNA, Muscle Fibers, Skeletal, MESH : Models, Biological, 030204 cardiovascular system & hematology, Tracking (particle physics), 030218 nuclear medicine & medical imaging, Section (fiber bundle), MESH : Muscle Fibers, 0302 clinical medicine, Orientation (geometry), MESH : Myocardium, Medicine, MESH : G2 Phase, Fiber, MESH : Adaptation, Physiological, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Polarized light microscopy, MESH : Tumor Suppressor Proteins, MESH: Infant, Newborn, MESH: Muscle Fibers, MESH: DNA, MESH : Protein Binding, General Medicine, MESH: Transcription Factors, Adaptation, Physiological, Azimuth, MESH: Reproducibility of Results, MESH: Heterochromatin, MESH: Microscopy, Polarization, Microscopy, Polarization, Cardiology and Cardiovascular Medicine, MESH : Chromosomal Proteins, Non-Histone, Pulmonary and Respiratory Medicine, MESH: Cell Line, Tumor, MESH: Myocardium, Heart Ventricles, MESH : Infant, Newborn, Models, Biological, 03 medical and health sciences, Optics, Fetal Heart, MESH : Neoplasm Proteins, MESH: Chromosomal Proteins, Non-Histone, Humans, MESH: Protein Binding, MESH: Tumor Suppressor Proteins, MESH : Microscopy, Polarization, MESH: Humans, Pixel, Plane (geometry), business.industry, MESH : Cell Line, Tumor, MESH : Heterochromatin, Myocardium, MESH : Reproducibility of Results, MESH : Humans, Infant, Newborn, MESH: Models, Biological, Reproducibility of Results, MESH : Nuclear Proteins, MESH : Fetal Heart, MESH: Adaptation, Physiological, MESH: G2 Phase, MESH: Fetal Heart, MESH : Heart Ventricles, Surgery, MESH: Heart Ventricles, business, MESH: Nuclear Proteins
Abstract: International audience; OBJECTIVE: To address the advantages and drawbacks of quantitative polarized light microscopy for the study of myocardial cell orientation and to identify its contribution in the field. METHODS: Quantitative polarized light microscopy allows to measure the orientation of myocardial fibers into the ventricular mass. For each pixel of a horizontal section, this orientation is the mean value of the directions of all myosin filaments contained in the thickness of the section for each pixel of the section and is accounted for by two angles, the azimuth angle, which is the angle of the fiber in the plane of the section, and the elevation angle, which measures the way the fiber escapes from the section. The azimuth is accurately measured, and its range of definition is complete from 0 degrees to 180 degrees . The elevation angle can be defined only in the range 0 degrees to 90 degrees . It is accurately measured between 20 degrees and 70 degrees . From 0 degrees to 20 degrees , there is a systematic bias raising the measured values, and from 70 degrees to 90 degrees , the angle is not accurately measured. RESULTS: With this method, we validated Streeter's conjecture concerning the architecture of the left ventricle. We formulated a pretzel conjecture about the fiber architecture of the whole ventricular mass during fetal period. In our model, elaborated by visual analysis of registered maps of orientation, the fibers run like geodesics on a nested set of 'pretzels'. Next, the validity of the helical ventricular myocardial band model of Torrent-Guasp has been examined. It appears that the band model does not account for the patterns observed in our data during the fetal period. However, after the major events of postnatal cardiovascular adaptation, our data can neither discard nor confirm Torrent-Guasp's model. CONCLUSIONS: Present limitations of quantitative polarized light analysis can neither confirm nor discard the existing models of fiber orientation in the whole ventricular mass after the neonatal period. However, the problems of mathematical and experimental validation of these two models have been posed in a rigorous manner. Non-ambiguous fiber tracking and demonstration of these models will require significant improvement of the definition range of the elevation angle that should be extended to 180 degrees .
Published: 2007

319. Differential optical spectroscopy for absorption characterization of scattering media

Author: Cyril Billet, Raphaël Sablong, Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Laboratoire Creatis, Compte Général
Subjects: Optics and Photonics, Optical fiber, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, Light, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 01 natural sciences, law.invention, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, law, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, Scattering, Radiation, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, Absorption (electromagnetic radiation), [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], Atomic and Molecular Physics, and Optics, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], Spectrophotometry, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.IB]Life Sciences [q-bio]/Bioengineering, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Materials science, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, Absorption, 010309 optics, Optics, Ultraviolet visible spectroscopy, Nephelometry and Turbidimetry, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, 0103 physical sciences, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Spectroscopy, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Models, Statistical, business.industry, Scattering, [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, 010401 analytical chemistry, Reproducibility of Results, Models, Theoretical, 0104 chemical sciences, Light intensity, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Attenuation coefficient, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, Diffuse reflection, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: article; Reflectance techniques are commonly used to characterize the optical properties of tissues. However, the precise determination of local chromophore concentrations in turbid media is usually difficult because of the nonlinear dependence of light intensity as a function of scattering and absorption coefficients. A technique is presented to easily determine absorbent compound concentration ratios in a turbid media from three optical reflectance spectra, in the visible range, measured for source-detector distances less than 1cm. The validity of the method is experimentally established, in cases of sets of diluted milk containing absorbent inks, over a relatively wide range of absorption (0.05-0.5 cm(-1)) and reduced scattering (10-20 cm(-1)) coefficients
Published: 2007

320. An operative gamma camera for sentinel lymph node procedure in case of breast cancer

Author: Carole Mathelin, Jean-Louis Guyonnet, S. Salvador, D. Huss, V Bekaert, Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Service de gynécologie–obstétrique, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Photomultiplier, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Sentinel lymph node, computer-aided so, Field of view, [SDV.CAN]Life Sciences [q-bio]/Cancer, PET PET/CT, Medical-image reconstruction methods and algorithms, 030218 nuclear medicine & medical imaging, law.invention, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Optics, law, medicine, Medical physics, Detectors and Experimental Techniques, Instrumentation, Gamma camera, coronary CT angiography (CTA), Mathematical Physics, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Physics, Large field of view, business.industry, Collimator, medicine.disease, 030220 oncology & carcinogenesis, SPECT, business, Gamma probe
Abstract: Large field of view gamma cameras are widely used to perform lymphoscintigraphy in the sentinel lymph nodes (SLN) procedure in case of breast cancer. However, they are not specified for this application and their sizes do not enable their use in the operative room to control the excision of the all SLN. We present the results obtained with a prototype of a new mini gamma camera developed especially for the operative lymphoscintigraphy of the axillary area in case of breast cancer. This prototype is composed of 10 mm thick parallel lead collimator, a 2 mm thick GSO:Ce inorganic scintillating crystal from Hitachi and a Hamamatsu H8500 flat panel multianode (64 channels) photomultiplier tube (MAPMT) equipped with a dedicated electronics. Its actual field of view is 50 × 50mm2. The gamma interaction position in the GSO scintillating plate is obtained by calculating the center of gravity of the fired MAPMT channels. The measurements performed with this prototype demonstrate the usefulness of this mini gamma camera for the pre, per and post-operative identification of SLN's and how its complementary role with an intraoperative handheld gamma probe enables to improve the efficiency of this practice. A 100 × 100mm2 field of view camera designated to cover the entire axillary area is under investigation.
Published: 2007

321. Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging data

Author: Radhika Srinivasan, Susan M. Noworolski, Michaël Sdika, Dominique Pelletier, Sarah J. Nelson, Hélène Ratiney, Roland G. Henry, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), and Laboratoire Creatis, Compte Général
Subjects: Male, Magnetic Resonance Spectroscopy, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Metabolite, MR spectroscopic imaging, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, computer.software_genre, 030218 nuclear medicine & medical imaging, chemistry.chemical_compound, 0302 clinical medicine, Nuclear magnetic resonance, Computer-Assisted, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Voxel, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, Tissue Distribution, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Mathematics, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, medicine.diagnostic_test, Radiological and Ultrasound Technology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], Magnetic resonance spectroscopic imaging, Brain, Signal Processing, Computer-Assisted, Magnetic Resonance Imaging, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Nuclear Medicine & Medical Imaging, [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, medicine.anatomical_structure, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], Radiology Nuclear Medicine and imaging, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Biomedical Imaging, Female, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Signal averaging, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Research Article, Adult, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, Metabolic Clearance Rate, Biophysics, Nerve Tissue Proteins, White matter, 03 medical and health sciences, Clinical Research, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Image Interpretation, Computer-Assisted, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Radiology, Nuclear Medicine and imaging, bootstrap, Image Interpretation, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], Monte Carlo simulation, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, Relaxation time T1 estimation, [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, relaxation time T-1 estimation, Neurosciences, Magnetic resonance imaging, Bootstrap, Standard error, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Bootstrapping (electronics), chemistry, Signal Processing, [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, computer, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: OBJECT: A novel method of estimating metabolite T1 relaxation times using MR spectroscopic imaging (MRSI) is proposed. As opposed to conventional single-voxel metabolite T1 estimation methods, this method investigates regional and gray matter (GM)/white matter (WM) differences in metabolite T1 by taking advantage of the spatial distribution information provided by MRSI. MATERIAL AND METHODS: The method, validated by Monte Carlo studies, involves a voxel averaging to preserve the GM/WM distribution, a non-linear least squares fit of the metabolite T1 and an estimation of its standard error by bootstrapping. It was applied in vivo to estimate the T1 of N-acetyl compounds (NAA), choline, creatine and myo-inositol in eight normal volunteers, at 1.5 T, using a short echo time 2D-MRSI slice located above the ventricles. RESULTS: WM-T 1,NAA was significantly (P < 0.05) longer in anterior regions compared to posterior regions of the brain. The anterior region showed a trend of a longer WM T1 compared to GM for NAA, creatine and myo-Inositol. Lastly, accounting for the bootstrapped standard error estimate in a group mean T1 calculation yielded a more accurate T1 estimation. CONCLUSION: The method successfully measured in vivo metabolite T1 using MRSI and can now be applied to diseased brain.
Published: 2007

322. Evaluating Brain Anatomical Correlations via Canonical Correlation Analysis of Sulcal Lines

Author: Pierre Fillard, Xavier Pennec, Paul Thompson, Nicholas Ayache, Analysis and Simulation of Biomedical Images (ASCLEPIOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratory of Neuro Imaging [Los Angeles] (LONI), University of California [Los Angeles] (UCLA), University of California-University of California, University of California (UC)-University of California (UC), INRIA, Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Modelling brain structure, function and variability based on high-field MRI data ( PARIETAL ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Inria Saclay - Ile de France, Laboratory of Neuro Imaging [Los Angeles] ( LONI ), and University of California at Los Angeles [Los Angeles] ( UCLA )
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, variability, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, brain, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, tensor, computational anatomy, Log-Euclidean, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, correlation, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Abstract: Modeling and understanding the degree of correlations between brain structures is a challenging problem in neuroscience. Correlated anatomic measures may arise from common genetic and trophic influences across brain regions, and may be overlooked if structures are modeled independently. Here, we propose a new method to analyze structural brain correlations based on a large set of cortical sulcal landmarks (72 per brain) delineated in 98 healthy subjects (age: 51.8 +/-6.2 years). First, we evaluate the correlation between any pair of sulcal positions via the total covariance matrix, a 6x6 symmetric positive-definite matrix. We use Log-Euclidean metrics to extrapolate this sparse field of total covariance matrices to obtain a dense representation. Second, we perform canonical correlation analysis to measure the degree of correlations between any two positions, and derive from it a p-value map for significance testing. We present maps of both local and long-range correlations, including maps of covariation between corresponding structures in opposite hemispheres, which show different degrees of hemispheric specialization. Results show that the central and inferior temporal sulci are highly correlated with their symmetric counterparts in the opposite brain hemisphere. Moreover, several functionally unrelated cortical landmarks show a high correlation as well. This structural dependence is likely attributable to common genetic programs, experience-driven plasticity, and coordinated brain growth or presence of anatomical links (neural fibers).
Published: 2007

323. Récidives ganglionnaires axillaires après lymphadénectomie sentinelle pour cancer du sein Axillary lymph node recurrence after sentinel lymph node biopsy for breast cancer

Author: Mathelin, C., Salvador, S., Guyonnet, J.L., Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Breast cancer, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Intraoperative gamma camera, [SDV.CAN]Life Sciences [q-bio]/Cancer, Axillary recurrence, CarolIReS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Lymphoscintigraphy, Sentinel lymph node, [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Abstract: Objectif L'objectif de cette mise au point est l'analyse des taux de récidives ganglionnaires axillaires (RA) après lymphadénectomie sélective (LS) pour cancer mammaire. Méthodes Les principales séries publiées entre 1995 et 2006, en langues française et anglaise, concernant la pratique de la LS en chirurgie mammaire et comportant les taux de RA ont été analysées. Résultats Lorsque la LS s'adresse à une population sélectionnée de patientes, elle est pratiquée avec une technique rigoureuse et après une formation et une expérience multidisciplinaire, elle est extrêmement fiable. Ainsi, lorsque le ganglion sentinelle est indemne de cellules cancéreuses, les taux de RA varient de 0 à 2 % avec un recul allant de 14 à 57 mois. Ces taux sont comparables à ceux observés après curage axillaire. Lorsque le ganglion sentinelle contient des cellules cancéreuses isolées ou des micrométastases, les taux de RA restent faibles, même si le curage axillaire complémentaire a été omis. Toutefois, la réalisation de ce curage axillaire complémentaire permet de réduire significativement les RA. La contribution des mini-gamma caméras opératoires pour l'optimisation de la procédure sentinelle est en cours d'évaluation. Objective The aim of this review is to summarize the current knowledge about axillary recurrences after sentinel lymph node (SLN) biopsy for breast cancer. Methods A Pubmed search for publications (in English or French) related to breast cancer, SLN and axillary recurrence was carried out from 1995 to 2006. Results Under controlled conditions (notably after a learning curve concerning the multidisciplinary team), the SLN procedure proved to be a reliable method for evaluation of axillary nodal status in selected patients with early-stage invasive breast cancer. When the SLN is free of cancer cells, the rate of axillary recurrence varies from 0% to 2% with a follow-up ranging from 14 to 57 months. Recurrence after axillary lymph node dissection is similar. When isolated cancer cells or micrometastases invaded the SLN, the rate of axillary recurrence remains low, but a complete axillary lymph node dissection must be performed to reduce this rate significantly. The use of intraoperative miniaturized gamma cameras could contribute to the optimization of the SLN procedure and to reduce axillary recurrences.
Published: 2007

324. Precise Localization of Sentinel Lymph Nodes and Estimation of Their Depth Using a Prototype Intraoperative Mini $\gamma$-Camera in Patients with Breast Cancer

Author: S. Salvador, D. Huss, Jean-Louis Guyonnet, Carole Mathelin, Service de gynécologie–obstétrique, CHU Strasbourg-Hôpital de Hautepierre [Strasbourg], Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Adult, medicine.medical_specialty, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Biopsy, Sentinel lymph node, Field of view, Breast Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030218 nuclear medicine & medical imaging, law.invention, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, breast cancer, lymphoscintigraphy, sentinel lymph node, law, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Gamma Cameras, Radionuclide Imaging, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Gamma camera, Aged, Neoplasm Staging, business.industry, Phantoms, Imaging, Sentinel Lymph Node Biopsy, Collimator, Middle Aged, medicine.disease, CarolIReS, intraoperative gamma-camera, Surgery, body regions, 030220 oncology & carcinogenesis, Female, Lymph, Lymph Nodes, Radiopharmaceuticals, Nuclear medicine, business
Abstract: The aim of this study was to evaluate the ability of a prototype intraoperative mini -camera, the CarolIReS, with a 50 x 50 mm field of view, to precisely localize sentinel lymph nodes (SLNs) and to determine their depth in a series of patients with infiltrative breast cancer requiring SLN excision. Methods: With the use of phantoms, the broadness of the signal of an acquired projection was shown to linearly depend on its distance from the collimator. A preclinical ex vivo study of 25 excised SLNs demonstrated that SLN size did not influence depth estimation. The minimum activity threshold for successful use of the proposed method was determined. After a preoperative radioisotope injection and lymphoscintigraphy, the SLN was localized in a series of 11 patients using both the mini -camera and a -probe. During surgery, a ruler was used to measure the depth of all SLNs before their excision. Results: Using the measured linear dependence of image broadness, we found that the expected SLN anatomic depth was compatible with its measured depth during surgery. Conclusion: This study showed that the mini -camera efficiently estimated the location of SLNs in 3 dimensions
Published: 2007

325. Study of 4 inorganic scintillating crystals for an operative gamma probe in radioguided surgery

Author: J L Guyonnet, S Salvador, Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Département Recherches Subatomiques ( DRS-IPHC ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique ( CNRS )
Subjects: Photon, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Sentinel lymph node, Physics::Medical Physics, [SDV.CAN]Life Sciences [q-bio]/Cancer, Scintillator, Lyso, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, Nuclear physics, Crystal, 03 medical and health sciences, 0302 clinical medicine, 030212 general & internal medicine, Instrumentation, Mathematical Physics, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, HgI etc), Physics, Resolution (electron density), Radiochemistry, Radioguided Surgery, CZT, HPG, 030220 oncology & carcinogenesis, Intra-operative probes, Gamma detectors (scintillators, Gamma probe
Abstract: In case of lymphatic cancers, the sentinel lymph node technique is performed using a gamma probe for intraoperative radioguided surgery. The inorganic scintillating crystal gamma probe developed at IPHC was equipped with 4 fast decay time inorganic scintillators: YAP, LYSO, LaCl3 and LaBr3. Energy resolutions are compared experimentally with single photon radioisotopes for small crystal cylinders (4 mm diameter, 12 mm length). The 6.1% measured energy resolution at 511 keV demonstrates the great advantage to use the high photon yield LaBr3 crystal for detection of γ-ray coming from positron annihilation using β+ radiomarked molecules.
Published: 2007

326. Clinical DT-MRI Estimation, Smoothing and Fiber Tracking with Log-Euclidean Metrics

Author: Pierre Fillard, Vincent Arsigny, N. Ayache, Xavier Pennec, Analysis and Simulation of Biomedical Images (ASCLEPIOS), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Modelling brain structure, function and variability based on high-field MRI data ( PARIETAL ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Inria Saclay - Ile de France, Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France
Subjects: [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Image quality, DT-MRI, Physics::Medical Physics, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Nerve Fibers, Myelinated, Regularization (mathematics), Pattern Recognition, Automated, 030218 nuclear medicine & medical imaging, Signal-to-noise ratio, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Computer vision, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Mathematics, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, Radiological and Ultrasound Technology, Computer Science Applications, symbols, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, Smoothing, [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, Noise reduction, Models, Neurological, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Sensitivity and Specificity, Log-Euclidean metrics, Tensor field, symbols.namesake, 03 medical and health sciences, Imaging, Three-Dimensional, tensor estimation, Artificial Intelligence, Rician fading, Image Interpretation, Computer-Assisted, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Maximum a posteriori estimation, Humans, Computer Simulation, Tensor, Riemannian geometry, Electrical and Electronic Engineering, Models, Statistical, business.industry, Reproducibility of Results, Pattern recognition, Image Enhancement, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Noise, Diffusion Magnetic Resonance Imaging, Gaussian noise, Artificial intelligence, business, Software, 030217 neurology & neurosurgery, Diffusion MRI
Abstract: International audience; Diffusion tensor magnetic resonance imaging (DT-MRI or DTI) is an imaging modality that is gaining importance in clinical applications. However, in a clinical environment, data have to be acquired rapidly, often at the expense of the image quality. This often results in DTI datasets that are not suitable for complex postprocessing like fiber tracking. We propose a new variational framework to improve the estimation of DT-MRI in this clinical context. Most of the existing estimation methods rely on a log-Gaussian noise (Gaussian noise on the image logarithms), or a Gaussian noise, that do not reflect the Rician nature of the noise in MR images with a low signal-to-noise ratio (SNR). With these methods, the Rician noise induces a shrinking effect: the tensor volume is underestimated when other noise models are used for the estimation. In this paper, we propose a maximum likelihood strategy that fully exploits the assumption of a Rician noise. To further reduce the influence of the noise, we optimally exploit the spatial correlation by coupling the estimation with an anisotropic prior previously proposed on the spatial regularity of the tensor field itself, which results in a maximum a posteriori estimation. Optimizing such a nonlinear criterion requires adapted tools for tensor computing. We show that Riemannian metrics for tensors, and more specifically the log-Euclidean metrics, are a good candidate and that this criterion can be efficiently optimized. Experiments on synthetic data show that our method correctly handles the shrinking effect even with very low SNR, and that the positive definiteness of tensors is always ensured. Results on real clinical data demonstrate the truthfulness of the proposed approach and show promising improvements of fiber tracking in the brain and the spinal cord.
Published: 2006

327. Measuring hemoglobin oxygen saturation during graded hypoxic hypoxia in rat striatum

Author: Adrian Bradu, Chantal Rémy, Jacques Derouard, Jean François Payen, Emmanuelle Grillon, Cécile Julien, Raphaël Sablong, Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Neuroimagerie Fonctionnelle et Metabolique, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Spectrométrie Physique (LSP), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Clinique de réanimation médicale, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble-Hôpital Michallon, Ligue Nationale Contre le Cancer, ACI Télémédecine et Technologies pour la Santé, Université Joseph Fourier - Grenoble 1 ( UJF ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire de Spectrométrie Physique ( LSP ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Centre National de la Recherche Scientifique ( CNRS ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble-Hôpital Albert Michallon, Dojat, Michel, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: MESH : Oxyhemoglobins, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Hypoxic hypoxia, Microdialysis, MESH : Corpus Striatum, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, Striatum, MESH: Spectrum Analysis, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Oxygen, [ SDV.IB.MN ] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, MESH: Corpus Striatum, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Fraction of inspired oxygen, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, Laser-Doppler Flowmetry, MESH : Female, MESH: Animals, MESH: Hypoxia, Brain, MESH: Microdialysis, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, Hypoxia, Brain, MESH: Laser-Doppler Flowmetry, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, MESH : Rats, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], MESH: Cerebrovascular Circulation, Laser Doppler velocimetry, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, Cerebral blood flow, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Anesthesia, Cerebrovascular Circulation, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.IB]Life Sciences [q-bio]/Bioengineering, Female, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, medicine.medical_specialty, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, MESH: Rats, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, chemistry.chemical_element, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, MESH : Rats, Wistar, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, MESH : Hypoxia, Brain, Internal medicine, MESH : Laser-Doppler Flowmetry, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, medicine, MESH : Microdialysis, Animals, Rats, Wistar, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], MESH : Spectrum Analysis, [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], business.industry, Spectrum Analysis, [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, MESH: Rats, Wistar, Corpus Striatum, Rats, Anesthesiology and Pain Medicine, Endocrinology, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, chemistry, Oxyhemoglobins, MESH: Oxyhemoglobins, MESH : Cerebrovascular Circulation, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, Hemoglobin, MESH : Animals, business, MESH: Female, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; We evaluated in vivo reflectance spectroscopy of visible light as a method to assess brain tissue hemoglobin oxygen saturation in rat striatum (SstrO2). Seven anesthetized and mechanically ventilated rats were subjected to incremental reduction in the fraction of inspired oxygen (Fio2): 0.35, 0.25, 0.15, 0.12, and 0.10, followed by a reoxygenation period (Group 1). At each episode, local changes in SstrO2 and in cerebral blood flow (LCBF) were simultaneously determined in the two striatal regions, using reflectance spectroscopy and laser Doppler flowmetry, respectively. Another group of rats (Group 2, n = 6) was also studied to measure sagittal sinus blood hemoglobin saturation (SssO2) during graded hypoxic hypoxia. Corpus striatum exhibited a significant graded decrease in SstrO2, from 38% +/- 17% at Fio2 of 0.35 (control) to 16% +/- 10% at Fio2 of 0.12 and to 13% +/- 7% at Fio2 of 0.10 (P < 0.05), with no difference between the two hemispheres. These local changes in SstrO2 were associated with a significant graded increase in LCBF: 161% +/- 26% of control values and 197% +/- 34% during these 2 hypoxic episodes, respectively (P < 0.05). All local changes were fully reversed during the reoxygenation period. In Group 2, SssO2 decreased from 38% +/- 8% at Fio2 of 0.35 (control) to 10% +/- 3% at Fio2 of 0.10, closely related to SstrO2 decreasing in hypoxia. This study shows that reflectance spectroscopy of the visible light in rat striatum could be a possible measure of continuous changes in SstrO2. SssO2 and LCBF measurements during graded hypoxic hypoxia indicate that changes in SstrO2 reflect primarily those in brain venous oxygenation.
Published: 2006

328. Estimation of metabolite concentrations of healthy mouse brain by magnetic resonance spectroscopy at 7 T

Author: Cudalbu, C., Cavassila, S., Ratiney, H., Grenier, D., Briguet, A., Graveron-Demilly, D., Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [ SDV.IB.MN ] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: article
Published: 2006

329. A non-rigid registration approach for quantifying myocardial contraction in tagged MRI using generalized information measures

Author: Francoise Preteux, Nicolas Rougon, Philippe Grenier, Caroline Petitjean, Philippe Cluzel, Département Advanced Research And Techniques For Multidimensional Imaging Systems ( ARTEMIS ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ), Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes ( LITIS ), Université Le Havre Normandie ( ULH ), Normandie Université ( NU ) -Normandie Université ( NU ) -Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Institut national des sciences appliquées Rouen Normandie ( INSA Rouen Normandie ), Normandie Université ( NU ), École des Mines de Paris, Service de radiologie, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Service de Radiologie Polyvalente Diagnostique et Interventionnelle, Département Advanced Research And Techniques For Multidimensional Imaging Systems (ARTEMIS), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), CHU Pitié-Salpêtrière [AP-HP], and Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
Subjects: Male, MESH: Myocardial Contraction, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Myocardial Ischemia, MESH : Myocardial Ischemia, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 030218 nuclear medicine & medical imaging, Mr tagging, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Image Processing, Computer-Assisted, Computer vision, MESH : Female, MR tagging, MESH : Algorithms, MESH : Myocardial Contraction, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Mathematics, Radiological and Ultrasound Technology, MESH: Magnetic Resonance Imaging, Cine, MESH : Adult, MESH : Magnetic Resonance Imaging, Cine, MESH: Image Processing, Computer-Assisted, Computer Graphics and Computer-Aided Design, MESH: Myocardial Ischemia, Female, Computer Vision and Pattern Recognition, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Algorithms, MESH : Image Processing, Computer-Assisted, Adult, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, Computation, MESH : Male, Magnetic Resonance Imaging, Cine, MESH: Algorithms, Health Informatics, Non-rigid registration, 03 medical and health sciences, Motion estimation, Medical imaging, Humans, Radiology, Nuclear Medicine and imaging, MESH: Humans, business.industry, MESH : Humans, Cardiac motion analysis, Generalized information measures, MESH: Adult, Myocardial function, Myocardial Contraction, MESH: Male, Artificial intelligence, business, MESH: Female, 030217 neurology & neurosurgery
Abstract: International audience; We address the problem of quantitatively assessing myocardial function from tagged MRI sequences. We develop a two-step method comprising (i) a motion estimation step using a novel variational non-rigid registration technique based on generalized information measures, and (ii) a measurement step, yielding local and segmental deformation parameters over the whole myocardium. Experiments on healthy and pathological data demonstrate that this method delivers, within a reasonable computation time and in a fully unsupervised way, reliable measurements for normal subjects and quantitative pathology-specific information. Beyond cardiac MRI, this work redefines the foundations of variational non-rigid registration for information-theoretic similarity criteria with potential interest in multimodal medical imaging.
Published: 2005

330. Virtual Reality and Augmented Reality in Digestive Surgery

Author: Jérôme Schmid, Nicholas Ayache, Xavier Pennec, Stéphane Nicolau, C. Koehl, Jacques Marescaux, Luc Soler, Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Université Louis Pasteur - Strasbourg I, MIRALab, Université de Genève = University of Geneva (UNIGE), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Université de Genève (UNIGE), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), and Université de Genève ( UNIGE )
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, medicine.medical_specialty, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Computer science, Image processing, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, 02 engineering and technology, Virtual reality, Surgical planning, Patient care, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, 0202 electrical engineering, electronic engineering, information engineering, medicine, Medical physics, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS, Simulation, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, Digestive surgery, 020207 software engineering, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, Augmented reality, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Gesture, Abdominal surgery
Abstract: Medical image processing led to a major improvement of patient care: the 3D modeling of patients from their CT-scan or MRI provides an improved surgical planning and simulation allows to train the surgical gesture before carrying it out. These two preoperative steps can be used intra-operatively with the development of augmented reality (AR). In this paper, we present the tools we developed to provide our first prototypal AR guiding system for abdominal surgery.
Published: 2005

331. Time-Domain Semi-Parametric Estimation Based on a Metabolite Basis Set

Author: Ratiney, H., Sdika, Michaël, Coenradie, Y., Cavassila, S., Van Ormondt, D., Graveron-Demilly, D., Centre de Recherche et d'Application en Traitement de l'Image et du Signal ( CREATIS ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon ( INSA Lyon ), Université de Lyon-Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Creatis, Compte Général, Centre de Recherche et d'Application en Traitement de l'Image et du Signal (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-École Supérieure Chimie Physique Électronique de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [SPI.OPTI] Engineering Sciences [physics]/Optics / Photonic, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TS] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM] Computer Science [cs]/Medical Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [ SDV.IB.MN ] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [ PHYS.PHYS.PHYS-MED-PH ] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SDV.IB ] Life Sciences [q-bio]/Bioengineering, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ PHYS.MECA.ACOU ] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL] Engineering Sciences [physics]/Signal and Image processing, [SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.IB] Life Sciences [q-bio]/Bioengineering, [SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph], [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-TI] Computer Science [cs]/Image Processing [eess.IV], [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism, [SDV.IB]Life Sciences [q-bio]/Bioengineering, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: article
Published: 2005

332. An augmented reality system to guide radio-frequency tumor ablation

Author: Stéphane Nicolau, Luc Soler, Nicholas Ayache, Alain Garcia, Xavier Pennec, Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), Université Louis Pasteur - Strasbourg I, Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Centre d'élaboration de matériaux et d'études structurales ( CEMES ), Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie du Solide, Université de Bordeaux ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Chimie de la Matière Condensée de Bordeaux ( ICMCB ), Analysis and Simulation of Biomedical Images ( ASCLEPIOS ), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Analysis and Simulation of Biomedical Images (ASCLEPIOS), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université de Bordeaux (UB), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, Computer science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, 02 engineering and technology, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Imaging phantom, Tumor ablation, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Robustness (computer science), 0202 electrical engineering, electronic engineering, information engineering, medicine, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Superimposition, Time processing, Simulation, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, Ablation, Computer Graphics and Computer-Aided Design, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 3. Good health, 020201 artificial intelligence & image processing, Augmented reality, Radio frequency, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Software
Abstract: Radio-frequency ablation is a difficult operative task that requires a precise needle positioning in the centre of the pathology. This article presents an augmented reality system for hepatic therapy guidance that superimposes in real-time 3D reconstructions (from CT acquisition) and a virtual model of the needle on external views of a patient. The superimposition of reconstructed models is performed with a 3D/2D registration based on radio-opaque markers stuck on to the patient's skin. The characteristics of the problem (accuracy, robustness and time processing) led us to develop automatic procedures to extract and match the markers and to track the needle in real time. Experimental studies confirmed that our algorithms are robust and reliable. Preliminary experiments conducted on a human abdomen phantom showed that our system is highly accurate (needle positioning error within 3 mm) and enables the surgeon to reach a target in less than 1 minute on average. Our next step will be to perform an in vivo evaluation. Copyright © 2005 John Wiley & Sons, Ltd.
Published: 2005

333. Re: Emergency gastroduodenal artery embolization by sandwich technique for angiographically obvious and oblivious, endotherapy failed bleeding duodenal ulcers

Author: Andrew Gee Seng Tan, G. Anil, W.-C. Teoh, K.-S. Ng, H.-W. Cheong, Service de radiologie et d'Imagerie médicale diagnostique et thérapeutique (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire Electronique, Informatique et Image ( Le2i ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire Electronique, Informatique et Image [UMR6306] (Le2i), Université de Bourgogne (UB)-École Nationale Supérieure d'Arts et Métiers (ENSAM), Arts et Métiers Sciences et Technologies, HESAM Université (HESAM)-HESAM Université (HESAM)-Arts et Métiers Sciences et Technologies, and HESAM Université (HESAM)-HESAM Université (HESAM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, medicine.medical_treatment, Peptic Ulcer Hemorrhage, 030218 nuclear medicine & medical imaging, Gastroduodenal artery, Hepatic Artery, MESH: Peptic Ulcer Hemorrhage, 0302 clinical medicine, MESH : Female, Embolization, CLIPS, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Sandwich technique, computer.programming_language, Aged, 80 and over, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, Mortality rate, General Medicine, Middle Aged, Embolization, Therapeutic, 3. Good health, Treatment Outcome, MESH : Hepatic Artery, Female, 030211 gastroenterology & hepatology, Radiology, MESH : Duodenal Ulcer, Adult, Reoperation, medicine.medical_specialty, MESH : Male, 03 medical and health sciences, Text mining, MESH : Peptic Ulcer Hemorrhage, MESH: Hepatic Artery, medicine.artery, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, medicine, Humans, Radiology, Nuclear Medicine and imaging, MESH : Embolization, Therapeutic, Aged, MESH: Humans, business.industry, MESH : Humans, medicine.disease, MESH: Male, Surgery, Radiography, MESH: Embolization, Therapeutic, Duodenal Ulcer, MESH: Duodenal Ulcer, Pancreatitis, Complication, business, computer, MESH: Female, Follow-Up Studies
Abstract: Aim To determine the feasibility, safety, and efficacy of adopting a standardized protocol for emergency transarterial embolization (TAE) of the gastroduodenal artery (GDA) with a uniform sandwich technique in endotherapy-failed bleeding duodenal ulcers (DU). Materials and methods Between December 2009 and December 2010, 15 patients with endotherapy-failed bleeding DU were underwent embolization. Irrespective of active extravasation, the segment of the GDA supplying the bleeding DU as indicated by endoscopically placed clips was embolized by a uniform sandwich technique with gelfoam between metallic coils. The clinical profile of the patients, re-bleeding, mortality rates, and response time of the intervention radiology team were recorded. The angioembolizations were reviewed for their technical success, clinical success, and complications. Mean duration of follow-up was 266.5 days. Results Active contrast-medium extravasation was seen in three patients (20%). Early re-bleeding was noted in two patients (13.33%). No patient required surgery. There was 100% technical success, while primary and secondary clinical success rates for TAE were 86.6 and 93.3%, respectively. Focal pancreatitis was the single major procedure-related complication. There was no direct bleeding-DU-related death. The response time of the IR service averaged 150 min (range 60–360 min) with mean value of 170 min. Conclusion Emergency embolization of the GDA using the sandwich technique is a safe and highly effective therapeutic option for bleeding DUs refractory to endotherapy. A prompt response from the IR service can be ensured with an institutional protocol in place for such common medical emergencies.
Published: 2013

334. FRET multiphoton spectral imaging microscopy of 7-ketocholesterol and Nile Red in U937 monocytic cells loaded with 7-ketocholesterol

Author: Kahn, E., Vejux, A., Dumas, D., Montange, T., Frédérique Frouin, Robert, V., Riedinger, J. M., Stoltz, J. F., Gambert, P., Todd-Pokropek, A., Lizard, G., Laboratoire d'Imagerie Fonctionnelle ( LIF ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire de Biochimie Moléculaire et Cellulaire ( LBMC ), Université de Bourgogne ( UB ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Laboratoire d'Energétique et de Mécanique Théorique Appliquée ( LEMTA ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Plate-forme Imagerie et Biophysique Cellulaire et Tissulaire ( PTIBC-IBISA Nancy ), Université Henri Poincaré - Nancy 1 ( UHP ), Analysis, perception and recognition of speech ( PAROLE ), INRIA Lorraine, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ) -Laboratoire Lorrain de Recherche en Informatique et ses Applications ( LORIA ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Université Henri Poincaré - Nancy 1 ( UHP ) -Université Nancy 2-Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Henri Poincaré - Nancy 1 ( UHP ) -Université Nancy 2-Institut National Polytechnique de Lorraine ( INPL ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Biologie Médicale [Centre Georges-François leclerc], Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc ( CRLCC - CGFL ), Plateforme Lipidomique [Dijon] ( LAP ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -IFR100 - Structure fédérative de recherche Santé-STIC-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biochimie Moléculaire et Cellulaire (LBMC), Université de Bourgogne (UB), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Plate-forme Imagerie et Biophysique Cellulaire et Tissulaire (PTIBC-IBISA Nancy), Université Henri Poincaré - Nancy 1 (UHP), Analysis, perception and recognition of speech (PAROLE), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS)-Université Henri Poincaré - Nancy 1 (UHP)-Université Nancy 2-Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon] (UNICANCER/CRLCC-CGFL), UNICANCER-UNICANCER, Plateforme Lipidomique [Dijon] (LAP), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-IFR100 - Structure fédérative de recherche Santé-STIC-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Dumas, Dominique, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Lorraine (INPL)-Université Nancy 2-Université Henri Poincaré - Nancy 1 (UHP)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique de Lorraine (INPL)-Université Nancy 2-Université Henri Poincaré - Nancy 1 (UHP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-IFR100 - Structure fédérative de recherche Santé-STIC-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)
Subjects: MESH: Cell Death, MESH: Fluorescence Resonance Energy Transfer, MESH: Mitochondria, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Flow Cytometry, MESH: Flow Cytometry, MESH: U937 Cells, MESH: Monocytes, Monocytes, Membrane Potentials, MESH : Staining and Labeling, MESH : Microscopy, Fluorescence, Multiphoton, Oxazines, Fluorescence Resonance Energy Transfer, Image Processing, Computer-Assisted, Humans, MESH: Membrane Potentials, MESH: Microscopy, Confocal, MESH : Membrane Potentials, MESH : Fluorescent Dyes, MESH : Microscopy, Confocal, Ketocholesterols, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Fluorescent Dyes, MESH : Ketocholesterols, Microscopy, Confocal, MESH: Humans, MESH : Oxazines, Cell Death, Staining and Labeling, MESH : Humans, MESH: Ketocholesterols, U937 Cells, Flow Cytometry, MESH: Fluorescent Dyes, MESH: Image Processing, Computer-Assisted, Mitochondria, MESH: Staining and Labeling, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Microscopy, Fluorescence, Multiphoton, MESH : Monocytes, MESH : Fluorescence Resonance Energy Transfer, MESH : Cell Death, MESH : U937 Cells, MESH: Microscopy, Fluorescence, Multiphoton, MESH : Mitochondria, MESH: Oxazines, MESH : Image Processing, Computer-Assisted
Abstract: To show the effect of 7-ketocholesterol (7KC) on cellular lipid content by means of flow cytometry and the interaction of 7KC with Nile Red (NR) via ultraviolet fluorescence resonance energy transfer (FRET) excitation of NR on U937 monocytic cells by means of 2-photon excitation confocal laser scanning microscopy (CLSM).Untreated and 7KC-treated U937 cells were stained with NR and analyzed by flow cytometry and CLSM. 3D sequences of images were obtained by spectral analysis in a 2-photon excitation CLSM and analyzed by the factor analysis of medical image sequences (FAMIS) algorithm, which provides factor curves and images. Factor images are the result of the FAMIS image processing method, which handles emission spectra. In FRET analysis, preparations are screened at selected UV wavelengths to avoid emission of NR in the absence of 7KC.During 7KC-induced cell death,flow cytometry and CLSM revealed a modification of the cellular lipid content. Factor images show FRET occurrence and subsequent colocalization of 7KC and NR.This investigation established the utility of 2-photon excitation CLSM to assess colocalization of 7KC with NR by FRET and to identify and distinguish polar and neutral lipids stained by NR that accumulate from the effect of 7KC.
Published: 2004

335. Retinotopic organization of visual mental images as revealed by functional magnetic resonance imaging

Author: Jean-François Mangin, Ferath Kherif, Jean-Baptiste Poline, Denis Le Bihan, Jessica Dubois, Guillaume Flandin, Stephen M. Kosslyn, Michel Denis, Isabelle Klein, Département de radiothérapie, CRLCC Val d'Aurelle - Paul Lamarque, Institut de recherche en cancérologie de Montpellier ( IRCM ), Université Montpellier 1 ( UM1 ) -CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Montpellier ( UM ), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Service Hospitalier Frédéric Joliot ( SHFJ ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Service NEUROSPIN ( NEUROSPIN ), Institut de Génétique et Développement de Rennes ( IGDR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -IFR140-Centre National de la Recherche Scientifique ( CNRS ), Biogéosciences [Dijon] ( BGS ), AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur ( LIMSI ), Université Paris-Sud - Paris 11 ( UP11 ) -Centre National de la Recherche Scientifique ( CNRS ), Department of Psychology, Harvard University ( Department of Psychology, Harvard University ), Université de Lille, Sciences Humaines et Sociales, IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Human Brain Research Center [Kyoto] ( HBRC ), Kyoto University [Kyoto], Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire d'Informatique pour la Mécanique et les Sciences de l'Ingénieur (LIMSI), Université Paris-Sud - Paris 11 (UP11)-Sorbonne Université - UFR d'Ingénierie (UFR 919), Sorbonne Université (SU)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université Paris Saclay (COmUE), Harvard University, Massachusetts General Hospital [Boston], Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Service NEUROSPIN (NEUROSPIN), Institut de Génétique et Développement de Rennes (IGDR), Centre National de la Recherche Scientifique (CNRS)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Department of Psychology, Harvard University (Department of Psychology, Harvard University), Harvard University [Cambridge], IFR de Neuroimagerie Fonctionnelle (IFR 49), Human Brain Research Center [Kyoto] (HBRC), and Le Bihan, Denis
Subjects: Male, Visual perception, MESH : Oxygen, genetic structures, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Brain Mapping, MESH : Photic Stimulation, Mental imagery, MESH: Magnetic Resonance Imaging, Behavioral Neuroscience, 0302 clinical medicine, Mental Processes, Cluster Analysis, MESH : Female, Evoked Potentials, MESH: Mental Processes, MESH: Brain Mapping, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Brain Mapping, medicine.diagnostic_test, 05 social sciences, fMRI, Retinotopy, MESH : Adult, Magnetic Resonance Imaging, Visual field, MESH: Evoked Potentials, medicine.anatomical_structure, MESH: Photic Stimulation, Imagination, Visual Perception, Female, Psychology, MESH : Visual Perception, MESH: Oxygen, Mental image, MESH : Orientation, Adult, MESH : Imagination, Cognitive Neuroscience, MESH : Mental Processes, MESH : Male, MESH: Acoustic Stimulation, MESH: Orientation, Experimental and Cognitive Psychology, Sensory system, MESH : Visual Cortex, 050105 experimental psychology, 03 medical and health sciences, Neuroimaging, MESH : Visual Pathways, Orientation, MESH : Magnetic Resonance Imaging, medicine, Humans, MESH : Cluster Analysis, 0501 psychology and cognitive sciences, Visual Pathways, Visual cortex, MESH: Imagination, MESH: Visual Pathways, MESH: Humans, MESH: Visual Perception, MESH : Evoked Potentials, MESH : Humans, MESH: Visual Cortex, MESH: Adult, MESH : Acoustic Stimulation, MESH: Cluster Analysis, MESH: Male, Oxygen, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Acoustic Stimulation, Functional magnetic resonance imaging, Neuroscience, MESH: Female, 030217 neurology & neurosurgery, Photic Stimulation
Abstract: International audience; In this study, we used event-related functional magnetic resonance imaging to investigate whether visual mental images retinotopically activate early visual cortex. Six participants were instructed to visualize or view horizontally or vertically oriented flashing bow-tie shaped stimuli. When compared to baseline, imagery globally activated Area V1. When the activation evoked by the stimuli at the different orientations was directly compared, distinct spatial activation patterns were obtained for each orientation in most participants. Not only was the topography of the activation patterns from imagery similar to the topography obtained with a corresponding visual perception task, but it closely matched the individual cortical representation of either the horizontal or the vertical visual field meridians. These findings strongly support that visual imagery and perception share low-level anatomical substrate and functional processes. Binding of spatial features is suggested as one possible mechanism.
Published: 2004

336. Analysis of fluorescent MRI contrast agent behavior in the liver and thoracic aorta of mice

Author: Kahn, E., Lizard, G., Dumas, D., Frédérique Frouin, Menetrier, F., Stoltz, J. F., Todd-Pokropek, A., Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Laboratoire Énergies et Mécanique Théorique et Appliquée (LEMTA ), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Plate-forme Imagerie et Biophysique Cellulaire et Tissulaire (PTIBC-IBISA Nancy), Université Henri Poincaré - Nancy 1 (UHP), Dumas, Dominique, Laboratoire d'Imagerie Fonctionnelle ( LIF ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ), Laboratoire d'Energétique et de Mécanique Théorique Appliquée ( LEMTA ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Plate-forme Imagerie et Biophysique Cellulaire et Tissulaire ( PTIBC-IBISA Nancy ), and Université Henri Poincaré - Nancy 1 ( UHP )
Subjects: [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Contrast Media, Aorta, Thoracic, Mice, MESH : Image Cytometry, MESH: Microscopy, Confocal, MESH : Female, MESH : Fluorescent Dyes, MESH: Animals, MESH : Algorithms, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, health care economics and organizations, Image Cytometry, Mice, Inbred BALB C, Microscopy, Confocal, MESH: Fluorescent Dyes, MESH: Staining and Labeling, Liver, MESH : Meglumine, Female, MESH : Organometallic Compounds, Algorithms, MESH: Aorta, Thoracic, education, MESH: Mice, Inbred BALB C, MESH: Algorithms, MESH: Meglumine, MESH : Staining and Labeling, Meglumine, MESH: Contrast Media, MESH : Mice, Organometallic Compounds, Animals, MESH : Microscopy, Confocal, MESH: Mice, MESH : Mice, Inbred BALB C, Fluorescent Dyes, MESH : Aorta, Thoracic, MESH : Contrast Media, Staining and Labeling, MESH : Liver, MESH: Organometallic Compounds, MESH : Xanthenes, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, Xanthenes, MESH: Xanthenes, MESH : Animals, MESH: Female, MESH: Image Cytometry, MESH: Liver
Abstract: To characterize the behavior of magnetofluorescent products injected in mice intravenously.The magnetic resonance imaging (MRI) products were labelled with fluorescent molecules to examine the biodistribution process in vivo and observe them at the cellular level by means of confocal microscopy. Three-dimensional (3D) sequences of images were obtained by spectral analysis of sample preparations in a multiphoton confocal microscope and analyzed by the factor analysis of medical image sequence algorithm, which provides factor curves. Factor images are the result of image-processing methods that utilize information from emission spectra. Preparations are also screened in the counting mode to provide fluorescent lifetime imaging microscopy (FLIM) characterizations.Factor images and FLIM images can help to analyze MRI targeting inside the liver and thoracic aorta of mice. They show positive detection of Fe-Texas red and BOPTA-Eu in the liver and positive detection of Fe-Texas red and negative detection of BOPTA-Eu inside the thoracic aorta.This investigation established the utility of fluorescent MRI contrast agents as in vivo staining tools for cellular sites.
Published: 2004

337. Role of the healthy hemisphere in recovery after resection of the supplementary motor area

Author: A.-L. Boch, P. Cornu, J.-F. Mangin, D. Le Bihan, Laurent Capelle, Hugues Duffau, Alexandre Krainik, Claude Marsault, Stéphane Lehéricy, Jacques Chiras, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Departement de neuroradiologie, CHU La Tronche, Hôpital Gui de Chauliac [CHU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de la Cognition et du Comportement, Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Département de neurochirurgie, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Service NEUROSPIN (NEUROSPIN), IFR de Neuroimagerie Fonctionnelle (IFR 49), Human Brain Research Center [Kyoto] (HBRC), Kyoto University, Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Neuro-anatomie fonctionnelle du comportement et de ses troubles, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Neurochirurgie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Kyoto University [Kyoto], Service de Neuroradiologie [CHU Pitié-Salpêtrière], Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Grenoble Institut des Neurosciences ( GIN ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Grenoble-Université Joseph Fourier - Grenoble 1 ( UJF ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Laboratoire d'Imagerie Fonctionnelle ( LIF ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Department of Neurosurgery, Assistance publique - Hôpitaux de Paris (AP-HP), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Service Hospitalier Frédéric Joliot ( SHFJ ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Service NEUROSPIN ( NEUROSPIN ), IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Human Brain Research Center [Kyoto] ( HBRC ), Service de neuro-radiologie [CHU Pitié-Salpêtrière], Centre de Neuro-Imagerie de Recherche ( CENIR ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR70-Université Pierre et Marie Curie - Paris 6 ( UPMC ), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
Subjects: Male, MESH : Movement, genetic structures, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Aged, MESH: Frontal Lobe, Postoperative recovery, MESH: Movement, Functional Laterality, 030218 nuclear medicine & medical imaging, MESH: Magnetic Resonance Imaging, MESH: Glioma, 0302 clinical medicine, Parietal Lobe, MESH : Neuronal Plasticity, MESH : Female, MESH: Neuronal Plasticity, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Aged, MESH: Parietal Lobe, Neuronal Plasticity, MESH: Middle Aged, Supplementary motor area, medicine.diagnostic_test, Brain Neoplasms, Motor Cortex, Glioma, MESH : Hand, Middle Aged, MESH : Adult, MESH : Motor Cortex, SMA, MESH: Recovery of Function, Magnetic Resonance Imaging, Frontal Lobe, medicine.anatomical_structure, MESH: Brain Neoplasms, MESH : Parietal Lobe, Cardiology, Female, Psychology, psychological phenomena and processes, Adult, MESH : Recovery of Function, medicine.medical_specialty, Movement, MESH : Male, behavioral disciplines and activities, MESH: Motor Cortex, Resection, MESH: Somatosensory Cortex, MESH: Hand, Premotor cortex, 03 medical and health sciences, MESH : Magnetic Resonance Imaging, Internal medicine, medicine, Humans, MESH : Frontal Lobe, MESH : Middle Aged, Tumor growth, MESH: Functional Laterality, MESH : Brain Neoplasms, MESH : Functional Laterality, Sensorimotor cortex, Aged, MESH: Humans, MESH : Humans, Magnetic resonance imaging, MESH: Adult, Recovery of Function, Somatosensory Cortex, Hand, MESH: Male, Surgery, MESH : Somatosensory Cortex, nervous system, MESH : Glioma, Neurology (clinical), MESH: Female, 030217 neurology & neurosurgery
Abstract: Objective: To determine the compensatory mechanisms involved in the recovery of motor function following surgical lesions of the supplementary motor area (SMA) and their relation to the clinical characteristics of recovery.Subjects and Methods: Twelve patients were referred for surgery of low-grade gliomas located in the SMA, and compared to eight healthy controls using fMRI before and after surgery during self-paced movements of both hands, successively. Magnitude and volume of activation within regions of interest (primary sensorimotor cortex, premotor cortex, SMA, preSMA, and parietal lobes) were compared and tested for correlation with anatomic characteristics of the tumor and resection, and clinical data.Results: Tumor growth induced preoperative underactivity in the adjacent SMA and overactivity in the opposite SMA. Postoperative recovery was associated with recruitment of a premotor network located in the healthy hemisphere including the SMA and the lateral premotor cortex. Postoperative premotor recruitment in the healthy hemisphere increased with the percentage of resection of preoperative SMA activation. Shortened onset and duration of recovery was associated with increased preoperative changes in activation levels.Conclusions: These findings suggest a dysfunction of the SMA ipsilateral to the tumor, partially compensated by a recruitment of the contralesional SMA which correlated with shortened postoperative recovery. SMA resection was compensated by the recruitment of a medial and lateral premotor circuitry in the healthy hemisphere.
Published: 2004

338. Traitements d'images médicales pour la planification, la simulation et l'aide intra-opératoire des actes chirurgicaux

Author: Luc Soler, Nicholas Ayache, Stéphane Nicolau, Xavier Pennec, Clément Forest, Hervé Delingette, Didier Mutter, Jacques Marescaux, Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Université Louis Pasteur - Strasbourg I, Faupel, M. and Smigielski, P. and Grzymala, R., Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), and Faupel, M. and Smigielski, P. and Grzymala, R.
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract: National audience; no abstract
Published: 2004

339. An Augmented Reality System to Guide Liver Punctures

Author: Stéphane Nicolau, Xavier Pennec, Luc Soler, Nicholas Ayache, Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), Université Louis Pasteur - Strasbourg I, Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), IRISA Rennes, Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), and Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Abstract: International audience; no abstract
Published: 2004

340. Virtual Reality, Augmented Reality and Robotics in surgical procedures of the liver

Author: Didier Mutter, Luc Soler, Xavier Pennec, Jacques Marescaux, Hervé Delingette, Nicholas Ayache, Clément Forest, Stéphane Nicolau, Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Université Louis Pasteur - Strasbourg I, Buzug, T.M. and Lueth, T.C., Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), and Buzug, T.M. and Lueth, T.C.
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, business.industry, Computer science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Robotics, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Surgical procedures, Virtual reality, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Human–computer interaction, 030220 oncology & carcinogenesis, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Augmented reality, Artificial intelligence, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, Simulation, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; no abstract
Published: 2004

341. Traitement d'images médicales pour la planification, la simulation et l'aide intra-opératoire des actes chirurgicaux

Author: Luc Soler, Nicholas Ayache, Stéphane Nicolau, Xavier Pennec, Clément Forest, Hervé Delingette, Jacques Marescaux, Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Université Louis Pasteur - Strasbourg I, Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), and Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS )
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract: National audience; no abstract
Published: 2004

342. Postoperative speech disorder after medial frontal surgery: role of the supplementary motor area

Author: P. Cornu, Stéphane Lehéricy, Laurent Capelle, Hugues Duffau, D. Le Bihan, Anne-Laure Boch, Alexandre Krainik, J.-F. Mangin, Claude Marsault, Hanna Chainay, Laurent D. Cohen, Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Departement de neuroradiologie, CHU La Tronche, IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Neuro-anatomie fonctionnelle du comportement et de ses troubles, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de la Cognition et du Comportement, Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Département de neurochirurgie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Service de Neurochirurgie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Service NEUROSPIN (NEUROSPIN), Human Brain Research Center [Kyoto] (HBRC), Kyoto University [Kyoto], Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Gui de Chauliac [CHU Montpellier], Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Kyoto University, Neuroimagerie Fonctionnelle et Metabolique, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Etude des Mécanismes Cognitifs (EMC), Université Lumière - Lyon 2 (UL2), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Department of Neurosurgery, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Centre de Neuro-Imagerie de Recherche ( CENIR ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR70-Université Pierre et Marie Curie - Paris 6 ( UPMC ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Laboratoire d'Imagerie Fonctionnelle ( LIF ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut de biologie et chimie des protéines [Lyon] ( IBCP ), Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Assistance publique - Hôpitaux de Paris (AP-HP), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Service Hospitalier Frédéric Joliot ( SHFJ ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Service NEUROSPIN ( NEUROSPIN ), Human Brain Research Center [Kyoto] ( HBRC ), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Université Lumière - Lyon 2 (UL2)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Male, Mutism, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Frontal Lobe, MESH: Risk Assessment, Neurosurgical Procedures, MESH: Magnetic Resonance Imaging, MESH: Glioma, [SCCO]Cognitive science, Postoperative Complications, Reference Values, MESH: Postoperative Complications, Verbal fluency test, MESH : Neuronal Plasticity, MESH : Female, Language disorder, MESH: Neuronal Plasticity, MESH : Risk Assessment, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS, Neuronal Plasticity, MESH: Middle Aged, MESH : Speech Disorders, Supplementary motor area, Brain Neoplasms, MESH: Reference Values, Glioma, Middle Aged, MESH : Adult, MESH : Neurosurgical Procedures, SMA, Magnetic Resonance Imaging, Frontal Lobe, medicine.anatomical_structure, Frontal lobe, [SCCO.PSYC]Cognitive science/Psychology, MESH: Brain Neoplasms, Female, medicine.symptom, Psychology, MESH: Mutism, Adult, medicine.medical_specialty, MESH: Speech Disorders, MESH : Male, MESH : Dominance, Cerebral, MESH : Reference Values, Risk Assessment, behavioral disciplines and activities, Speech Disorders, Central nervous system disease, Communication disorder, MESH : Magnetic Resonance Imaging, medicine, Humans, MESH : Frontal Lobe, MESH : Middle Aged, MESH : Mutism, Dominance, Cerebral, MESH : Brain Neoplasms, MESH: Humans, [SCCO.NEUR]Cognitive science/Neuroscience, MESH : Humans, MESH: Adult, MESH: Neurosurgical Procedures, MESH: Dominance, Cerebral, medicine.disease, MESH: Male, Surgery, MESH : Glioma, Speech disorder, MESH : Postoperative Complications, Neurology (clinical), MESH: Female
Abstract: Background: Patients undergoing surgical resection of medial frontal lesions may present transient postoperative speech disorders that remain largely unpredictable.Objective: To relate the occurrence of this speech deficit to the specific surgical lesion of the supplementary motor area (SMA) involved during language tasks using fMRI.Methods: Twelve patients were studied using a verbal fluency task before resection of a low-grade glioma of the medial frontal lobe and compared with six healthy subjects. Pre- and postoperative MR variables including the hemispheric dominance for language, the extent of SMA removal, and the volume of resection were compared to the clinical outcome.Results: Following surgery, 6 of 12 patients presented speech disorders. The deficit was similar across patients, consisting of a global reduction in spontaneous speech, ranging from a complete mutism to a less severe speech reduction, which recovered within a few weeks or months. The occurrence of the deficit was related to the resection of the activation in the SMA of the dominant hemisphere for language (p < 0.01). Increased activation in the SMA of the healthy hemisphere on the preoperative fMRI was observed in patients with postoperative speech deficit.Conclusions: fMRI is able to identify the area at risk in the SMA, of which resection is related to the occurrence of characteristic transient postoperative speech disorders. Increased SMA activation in the healthy hemisphere suggested that a plastic change of SMA function occurred in these patients.
Published: 2003

343. Vision augmentée de structures anatomiques abdominales recalées par stéréoscopie

Author: Stéphane Nicolau, Xavier Pennec, Luc Soler, Nicholas Ayache, Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), Université Louis Pasteur - Strasbourg I, Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
Subjects: [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Abstract: National audience; no abstract
Published: 2003

344. Augmented Reality guided radio-frequency tumor ablation

Author: Stéphane Nicolau, Alain Garcia, Xavier Pennec, Luc Soler, Nicholas Ayache, Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery ( IRCAD/EITS ), Université Louis Pasteur - Strasbourg I, Medical imaging and robotics ( EPIDAURE ), Inria Sophia Antipolis - Méditerranée ( CRISAM ), Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Centre d'élaboration de matériaux et d'études structurales ( CEMES ), Institut National des Sciences Appliquées - Toulouse ( INSA Toulouse ), Institut National des Sciences Appliquées ( INSA ) -Institut National des Sciences Appliquées ( INSA ) -Université Paul Sabatier - Toulouse 3 ( UPS ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire de Chimie du Solide, Université de Bordeaux ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Chimie de la Matière Condensée de Bordeaux ( ICMCB ), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré ( LHSP ), Université de Lorraine ( UL ) -Centre National de la Recherche Scientifique ( CNRS ), Institut de Recherche Contre les Cancers de l'Appareil Digestif-European Institute of Telesurgery (IRCAD/EITS), Medical imaging and robotics (EPIDAURE), Inria Sophia Antipolis - Méditerranée (CRISAM), Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Centre d'élaboration de matériaux et d'études structurales (CEMES), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Polytechnique de Bordeaux-Université de Bordeaux (UB), Laboratoire d'Histoire des Sciences et de Philosophie - Archives Henri Poincaré (LHSP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut de Chimie de Toulouse (ICT-FR 2599), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB), and Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)
Subjects: validation, [ INFO.INFO-MO ] Computer Science [cs]/Modeling and Simulation, [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, 3D/2D registration, Augmented reality, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, ComputingMilieux_MISCELLANEOUS, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Abstract: International audience; no abstract
Published: 2003

345. Role of the supplementary motor area in motor deficit following medial frontal lobe surgery

Author: Anne-Laure Boch, Laurent Capelle, Hugues Duffau, Stéphane Lehéricy, Claude Marsault, Charles-Ambroise Valery, Michaela Vlaicu, P. Cornu, J.-F. Mangin, D. Le Bihan, Alexandre Krainik, Fabrice Poupon, M. Sahel, Stéphane Clemenceau, Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de neuro-radiologie, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Departement de neuroradiologie, CHU La Tronche, IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Neuro-anatomie fonctionnelle du comportement et de ses troubles, Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR70-Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital Gui de Chauliac, Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Laboratoire de la Cognition et du Comportement, Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), Département de neurochirurgie, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Cités, Territoires, Environnement et Sociétés (CITERES), Centre National de la Recherche Scientifique (CNRS)-Université de Tours, Service de Neurochirurgie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire d'Imagerie Fonctionnelle (LIF), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale (INSERM), Cortex et Epilepsie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Service Hospitalier Frédéric Joliot (SHFJ), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Center for Neuroscience and Behavioral Medicine, Children's National Medical Center, Service NEUROSPIN (NEUROSPIN), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS)-Université de Tours (UT), Grenoble Institut des Neurosciences ( GIN ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Grenoble-Université Joseph Fourier - Grenoble 1 ( UJF ), Université Joseph Fourier - Grenoble 1 ( UJF ) -CHU Grenoble, IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Centre de Neuro-Imagerie de Recherche ( CENIR ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR70-Université Pierre et Marie Curie - Paris 6 ( UPMC ), Université Montpellier 1 ( UM1 ) -Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Régional Universitaire [Montpellier] ( CHRU Montpellier ), Cités, Territoires, Environnement et Sociétés ( CITERES ), Université de Tours-Centre National de la Recherche Scientifique ( CNRS ), Laboratoire d'Imagerie Fonctionnelle ( LIF ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR14-IFR49-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP], Department of Neurosurgery, Assistance publique - Hôpitaux de Paris (AP-HP), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Service Hospitalier Frédéric Joliot ( SHFJ ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Service NEUROSPIN ( NEUROSPIN ), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Gui de Chauliac [CHU Montpellier], Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Grenoble-Université Joseph Fourier - Grenoble 1 (UJF), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université de Tours-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [APHP]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), and Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)
Subjects: Male, MESH : Retrospective Studies, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Aged, MESH: Frontal Lobe, Neurological disorder, 030218 nuclear medicine & medical imaging, MESH: Magnetic Resonance Imaging, Postoperative Complications, 0302 clinical medicine, MESH: Postoperative Complications, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Aged, MESH: Middle Aged, Supplementary motor area, medicine.diagnostic_test, Brain Neoplasms, Motor Cortex, MESH : Adult, MESH : Motor Cortex, Middle Aged, SMA, Magnetic Resonance Imaging, Frontal Lobe, Motor Skills Disorders, medicine.anatomical_structure, Frontal lobe, MESH : Motor Skills Disorders, MESH: Brain Neoplasms, Psychology, MESH: Motor Skills Disorders, Adult, medicine.medical_specialty, Spontaneous movements, MESH : Male, MESH: Motor Cortex, 03 medical and health sciences, MESH : Magnetic Resonance Imaging, medicine, MESH : Frontal Lobe, Humans, MESH : Middle Aged, MESH : Brain Neoplasms, Aged, Retrospective Studies, MESH: Humans, MESH : Humans, Magnetic resonance imaging, Retrospective cohort study, MESH: Adult, MESH: Retrospective Studies, medicine.disease, MESH: Male, Surgery, MESH : Postoperative Complications, Neurology (clinical), Motor Deficit, 030217 neurology & neurosurgery
Abstract: International audience; OBJECTIVE: Patients undergoing surgical resection of medial frontal lesions may present a transient postoperative deficit that remains largely unpredictable. The authors studied the role of the supplementary motor area (SMA) in the occurrence of this deficit using fMRI. METHODS: Twenty-three patients underwent a preoperative fMRI before resection of medial frontal lesions. Tasks included self-paced flexion/extension of the left and right hand, successively. Preoperative fMRI data were compared with postoperative MRI data and with neurologic outcome. RESULTS: Following surgery, 11 patients had a motor deficit from which all patients recovered within a few weeks or months. The deficit was similar across patients, consisting of a global reduction in spontaneous movements contralateral to the operated side with variable severity. SMA activation was observed in all patients. The deficit was observed when the area activated in the posterior part of the SMA (SMA proper) was resected. CONCLUSIONS: fMRI is able to identify the area at risk in the SMA proper whose resection is highly related to the occurrence of the motor deficit. The clinical characteristics of this deficit support the role of the SMA proper in the initiation and execution of the movement.
Published: 2001

346. Functional imaging in the work-up of childhood epilepsy

Author: Olivier Dulac, András Holló, Marie Bourgeois, Pierre Vera, D. LeBihan, C. Cieuta, Anna Kaminska, Dorothée Ville, Catherine Chiron, P. F. Van de Morteele, Francis Brunelle, Lucie Hertz-Pannier, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Service de neurologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institute of Physics, Polish Academy of Sciences, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Génétique et pathologie moléculaires de l'hématopoïèse, Institut National de la Santé et de la Recherche Médicale (INSERM), PSA Peugeot - Citroën (PSA), PSA Peugeot Citroën (PSA), Institut du Pin, Université Sciences et Technologies - Bordeaux 1 (UB), Service de radiologie pédiatrique [CHU Necker], Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), Le Bihan, Denis, Université Sciences et Technologies - Bordeaux 1, Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes ( LITIS ), Institut national des sciences appliquées Rouen Normandie ( INSA Rouen Normandie ), Normandie Université ( NU ) -Normandie Université ( NU ) -Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Université Le Havre Normandie ( ULH ), Normandie Université ( NU ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Institute of Physics, Polish Academy of Sciences, ( PAS ), Institute of Physics, Institut National de la Santé et de la Recherche Médicale ( INSERM ), PSA Peugeot - Citroën ( PSA ), Peugeot-Citroën, Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), and Service Hospitalier Frédéric Joliot ( SHFJ )
Subjects: Male, MESH : Brain Mapping, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Language Tests, MESH : Child, Preschool, Ictal-Interictal SPECT Analysis by SPM, 030218 nuclear medicine & medical imaging, MESH: Magnetic Resonance Imaging, Epilepsy, 0302 clinical medicine, MESH : Child, MESH: Child, Child, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Brain Mapping, Brain Mapping, Language Tests, medicine.diagnostic_test, MESH : Epilepsy, MESH: Energy Metabolism, Brain, Cognition, MESH : Infant, MESH : Regional Blood Flow, General Medicine, MESH : Adult, Magnetic Resonance Imaging, MESH: Infant, Child, Preschool, MESH: Epilepsy, Wada test, Neurosurgery, MESH : Tomography, Emission-Computed, Single-Photon, Tomography, Emission-Computed, Adult, medicine.medical_specialty, Adolescent, MESH : Male, MESH : Language Tests, MESH: Tomography, Emission-Computed, MESH : Dominance, Cerebral, Lateralization of brain function, MESH: Tomography, Emission-Computed, Single-Photon, 03 medical and health sciences, MESH: Brain, MESH : Adolescent, MESH : Magnetic Resonance Imaging, medicine, Humans, Ictal, Dominance, Cerebral, Tomography, Emission-Computed, Single-Photon, MESH: Adolescent, MESH: Humans, business.industry, MESH : Humans, MESH: Child, Preschool, Infant, MESH: Adult, MESH: Dominance, Cerebral, medicine.disease, MESH: Male, Functional imaging, MESH : Energy Metabolism, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Brain, Regional Blood Flow, Pediatrics, Perinatology and Child Health, MESH: Regional Blood Flow, Neurology (clinical), Nuclear medicine, business, Energy Metabolism, MESH : Tomography, Emission-Computed, Neuroscience, 030217 neurology & neurosurgery
Abstract: International audience; In children with medically intractable lesional epilepsy, surgery is deemed successful if the epileptogenic focus can be removed while major neurological functions are spared. Current techniques rely on invasive intracranial recordings. The new developments in functional imaging offer the possibility of localizing the epileptogenic focus noninvasively (PET/SPECT) and mapping cognitive functions (fMRI). Ictal SPECT shows hyperperfusion in the focus and has proved to have better localizing value than interictal PET or SPECT, which show focal hypometabolism or hypoperfusion. Ictal SPECT is useful for deciding on the placement of intracranial electrodes in extratemporal epilepsies, particularly in young children. Functional MRI has proved highly accurate for localizing motor and language networks, thus offering the possibilities of replacing the Wada test (language hemispheric lateralization) and studying postlesional brain plasticity. Despite the difficulties of functional imaging in children owing to the limited cooperation that can be expected, ethical constraints, and poor normative data, SPECT/PET and fMRI provide clinically useful information for presurgical work-up of childhood epilepsies.
Published: 2001

347. [Brain functional MRI: physiological, technical, and methodological bases, and clinical applications]

Author: Hertz-Pannier, Lucie, Lehéricy, Stéphane, Cordoliani, Y., Le Bihan, D., Marsault, C., Brunelle, F., IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Centre de Neuro-Imagerie de Recherche ( CENIR ), Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Neuro-anatomie fonctionnelle du comportement et de ses troubles, Institut National de la Santé et de la Recherche Médicale ( INSERM ) -IFR70-Université Pierre et Marie Curie - Paris 6 ( UPMC ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Service Hospitalier Frédéric Joliot ( SHFJ ), Service de radiologie pédiatrique [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Centre de Neuro-Imagerie de Recherche (CENIR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR70-Institut National de la Santé et de la Recherche Médicale (INSERM), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Service Hospitalier Frédéric Joliot (SHFJ), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Center for NeuroImaging Research-Human MRI Neuroimaging core facility for clinical research [ICM Paris] (CENIR), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: MESH: Preoperative Care, Adult, Brain Diseases, MESH: Humans, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Humans, Brain, MESH: Adult, MESH : Adult, Magnetic Resonance Imaging, MESH: Magnetic Resonance Imaging, MESH: Brain, MESH : Preoperative Care, MESH : Brain, MESH : Child, MESH: Child, MESH : Magnetic Resonance Imaging, Preoperative Care, Humans, Female, Child, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging
Abstract: International audience; Brain functional MRI (fMRI) provides an indirect mapping of cerebral activity, based on the detection of the local blood flow and oxygenation changes following neuronal activity (BOLD contrast, Blood Oxygenation Level Dependent). fMRI allows us to study non invasively the normal and pathological aspects of cortical functional organization. Each fMRI study compares two different states of activity. Echo-Planar Imaging (EPI) is the technic of choice that makes it possible to study the whole brain at a rapid pace. Activation maps are calculated from a statistical analysis of the local signal changes. Functional MRI is now becoming an essential tool in the neurofunctional work-up of many neurosurgery patients, as well as the reference method to image normal or pathologic functional brain organization in adults and children.
Published: 2000

348. Noninvasive assessment of language dominance in children and adolescents with functional MRI: a preliminary study

Author: Hertz-Pannier, L., Gaillard, W. D., Mott, S. H., Charles Andre Cuenod, Bookheimer, S. Y., Weinstein, S., Conry, J., Papero, P. H., Schiff, S. J., Le Bihan, D., Theodore, W. H., Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Department of Health and Human Services, National Institutes of Health ( NIH ), Méthodes d'imagerie des échanges transcapillaires ( LRI ), IFR94-Université Paris Descartes - Paris 5 ( UPD5 ), Laboratoire de Recherche en Imagerie LRI-EA4062, Université Paris Descartes - Paris 5 ( UPD5 ), IFR de Neuroimagerie Fonctionnelle ( IFR 49 ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Service Hospitalier Frédéric Joliot ( SHFJ ), National Institutes of Health [Bethesda] ( NIH ), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, National Institutes of Health [Bethesda] (NIH), Méthodes d'imagerie des échanges transcapillaires (LRI), IFR94-Université Paris Descartes - Paris 5 (UPD5), Université Paris Descartes - Paris 5 (UPD5), IFR de Neuroimagerie Fonctionnelle (IFR 49), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service Hospitalier Frédéric Joliot (SHFJ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and Le Bihan, Denis
Subjects: MESH : Feasibility Studies, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Brain Mapping, MESH : Male, MESH : Dominance, Cerebral, MESH: Magnetic Resonance Imaging, MESH: Brain, MESH : Child, MESH : Verbal Behavior, MESH: Child, MESH : Adolescent, MESH : Magnetic Resonance Imaging, MESH : Female, MESH: Brain Mapping, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, MESH: Adolescent, MESH: Verbal Behavior, MESH: Humans, MESH : Humans, MESH: Dominance, Cerebral, MESH: Male, MESH: Epilepsies, Partial, MESH : Epilepsies, Partial, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, MESH : Brain, MESH: Feasibility Studies, MESH: Female
Abstract: International audience; BACKGROUND: Assessment of language organization is crucial in patients considered for epilepsy surgery. In children, the current techniques, intra-carotid amobarbital test (IAT) for language dominance, and cortical electrostimulation mapping (ESM), are invasive and risky. Functional magnetic resonance imaging (fMRI) is an alternative method for noninvasive functional mapping, through the detection of the hemodynamic changes associated with neuronal activation. We used fMRI, to assess language dominance in children with partial epilepsy. METHODS: Eleven right handed children and adolescents performed a word generation task during fMRI acquisition focused on the frontal lobes. Areas where the signal time course correlated with the test paradigm (r = 0.7) were considered activated. Extent and magnitude of signal changes were used to calculate asymmetry indices. Seven patients had IAT, ESM, or surgery outcome available for comparison. RESULTS: fMRI language dominance always agreed with IAT (6 cases) and ESM (1 case), showing left dominance in six and bilateral language in one. fMRI demonstrated left dominance in three additional children, and right dominance in one with early onset of left temporal epilepsy. Four children whose initial studies were equivocal due to noncompliance or motion artifacts were restudied successfully. CONCLUSIONS: fMRI can be used to assess language lateralization noninvasively in children. It has the potential to replace current functional mapping techniques in patients, and to provide important data on brain development.
Published: 1997

349. Anomalous transverse relaxation in 1H spectroscopy in human brain at 4 Tesla

Author: Robert C. Risinger, Denis Le Bihan, S. Posse, Robert S. Balaban, Charles A. Cuenod, Department of Health and Human Services, National Institutes of Health [Bethesda] (NIH), Méthodes d'imagerie des échanges transcapillaires (LRI), IFR94-Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Recherche en Imagerie LRI-EA4062, Université Paris Descartes - Paris 5 (UPD5), Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Univ Fed Rio Grande do Norte, Dept Chem (LAPET), Univ Fed Rio Grande do Norte, Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), National Institutes of Health ( NIH ), Méthodes d'imagerie des échanges transcapillaires ( LRI ), IFR94-Université Paris Descartes - Paris 5 ( UPD5 ), Université Paris Descartes - Paris 5 ( UPD5 ), National Institutes of Health [Bethesda] ( NIH ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, Univ Fed Rio Grande do Norte, Dept Chem ( LAPET ), and Le Bihan, Denis
Subjects: Intracellular Fluid, MESH : Motion, Magnetic Resonance Spectroscopy, Proton, Phosphocreatine, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, Analytical chemistry, MESH : Aspartic Acid, MESH: Signal Processing, Computer-Assisted, MESH: Aspartic Acid, MESH : Artifacts, MESH : Choline, 030218 nuclear medicine & medical imaging, Choline, Diffusion, Paramagnetism, chemistry.chemical_compound, 0302 clinical medicine, Nuclear magnetic resonance, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, Fourier Analysis, MESH: Creatine, MESH: Intracellular Fluid, MESH : Hydrogen, Relaxation (NMR), MESH: Hydrogen, MESH: Choline, Brain, Pulse sequence, Signal Processing, Computer-Assisted, MESH: Diffusion, Nuclear magnetic resonance spectroscopy, Human brain, MESH : Creatine, medicine.anatomical_structure, MESH: Artifacts, MESH : Electron Spin Resonance Spectroscopy, Occipital Lobe, MESH: Image Enhancement, Artifacts, MESH: Occipital Lobe, MESH: Motion, MESH: Phosphocreatine, 03 medical and health sciences, Motion, MESH: Brain, MESH: Body Water, Body Water, medicine, Humans, Radiology, Nuclear Medicine and imaging, MESH : Phosphocreatine, Spectroscopy, MESH : Diffusion, Aspartic Acid, MESH : Signal Processing, Computer-Assisted, MESH : Body Water, MESH : Occipital Lobe, MESH: Humans, MESH: Magnetic Resonance Spectroscopy, MESH : Humans, Electron Spin Resonance Spectroscopy, Creatine, Image Enhancement, nervous system diseases, MESH : Fourier Analysis, [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, chemistry, MESH : Brain, nervous system, MESH : Image Enhancement, MESH : Magnetic Resonance Spectroscopy, MESH: Electron Spin Resonance Spectroscopy, 030217 neurology & neurosurgery, MESH: Fourier Analysis, Hydrogen, MESH : Intracellular Fluid
Abstract: International audience; Longitudinal (T1) and apparent transverse relaxation times (T2) of choline-containing compounds (Cho), creatine/phosphocreatine (Cr/PCr), and N-acetyl aspartate (NAA) were measured in vivo in human brain at 4 Tesla. Measurements were performed using a water suppressed stimulated echo pulse sequence with complete outside volume presaturation to improve volume localization at short echo times. T1-values of Cho (1.2 +/- 0.1 s), Cr (1.6 +/- 0.3 s), and NAA (1.6 +/- 0.2 s) at 4 Tesla in occipital brain were only slightly larger than those reported in the literature at 1.5 Tesla. Thus, TR will not adversely affect the expected enhancement of signal-to-noise at 4 Tesla. Surprisingly, apparent T2-values of Cho (142 +/- 34 ms), Cr (140 +/- 13 ms), and NAA (185 +/- 24 ms) at 4 Tesla were significantly smaller than those at 1.5 Tesla and further decreased when increasing the mixing interval TM. Potential contributing factors, such as diffusion in local susceptibility related gradients, dipolar relaxation due to intracellular paramagnetic substances and motion effects are discussed. The results suggest that short echo time spectroscopy is advantageous to maintain signal to noise at 4 Tesla.
Published: 1995

350. Brain functional imaging at 1.5T: Fesibility and comparison between conventional gradient echo sequences and echo-planar imaging

Author: Hertz-Pannier, Lucie, Cuénod, C. A., Posse, S., Jezzard, P., Prinster, A., Turner, R., Le Bihan, Denis, Le Bihan, Denis, Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Department of Health and Human Services, National Institutes of Health [Bethesda] (NIH), Méthodes d'imagerie des échanges transcapillaires (LRI), IFR94-Université Paris Descartes - Paris 5 (UPD5), Laboratoire de Recherche en Imagerie LRI-EA4062, Université Paris Descartes - Paris 5 (UPD5), Service Hospitalier Frédéric Joliot (SHFJ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay, National Institutes of Health ( NIH ), Méthodes d'imagerie des échanges transcapillaires ( LRI ), IFR94-Université Paris Descartes - Paris 5 ( UPD5 ), Université Paris Descartes - Paris 5 ( UPD5 ), Service Hospitalier Frédéric Joliot ( SHFJ ), National Institutes of Health [Bethesda] ( NIH ), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)
Subjects: [SDV.IB.IMA] Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 1995

Catalog

Books, media, physical & digital resources

See catalog results

Searchworks

Select search scope, currently: Articles Catalog books, media & more in Jio Institute collections Articles journal articles & other e-resources

Search

Search Constraints

Refine your results

Search Limiters

Topic

Publication Year Range

Language

Journal

Database

Publisher

364 results on '"[ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging"'

Search Results

Catalog

Select search scope, currently: Articles

Catalog

books, media & more in Jio Institute collections

Articles

journal articles & other e-resources