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2,101 results on '"d'Andréa, R."'

253. SARS-CoV-2 Post-Infection and Sepsis by Saccharomyces cerevisiae: A Fatal Case Report—Focus on Fungal Susceptibility and Potential Virulence Attributes

Author

Lívia S. Ramos, Luca Mokus, Heloisa F. Frota, Marcos V. Santos, Simone S. C. Oliveira, Manoel M. E. Oliveira, Gisela L. Costa, Ana Luísa Alves, Andréa R. Bernardes-Engemann, Rosane Orofino-Costa, Ana Carolina Aor, Marta H. Branquinha, and André L. S. Santos

Subjects
COVID-19, fungal infection, hydrolytic enzymes, biofilm formation, Tenebrio molitor, Medicine
Abstract

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been responsible for approximately 6.8 million deaths worldwide, threatening more than 753 million individuals. People with severe coronavirus disease-2019 (COVID-19) infection often exhibit an immunosuppression condition, resulting in greater chances of developing co-infections with bacteria and fungi, including opportunistic yeasts belonging to the Saccharomyces and Candida genera. In the present work, we have reported the case of a 75-year-old woman admitted at a Brazilian university hospital with an arterial ulcer in the left foot, which was being prepared for surgical amputation. The patient presented other underlying diseases and presented positive tests for COVID-19 prior to hospitalization. She received antimicrobial treatment, but her general condition worsened quickly, leading to death by septic shock after 4 days of hospitalization. Blood samples collected on the day she died were positive for yeast-like organisms, which were later identified as Saccharomyces cerevisiae by both biochemical and molecular methods. The fungal strain exhibited low minimal inhibitory concentration values for the antifungal agents tested (amphotericin B, 5-flucytosine, caspofungin, fluconazole and voriconazole), and it was able to produce important virulence factors, such as extracellular bioactive molecules (e.g., aspartic peptidase, phospholipase, esterase, phytase, catalase, hemolysin and siderophore) and biofilm. Despite the activity against planktonic cells, the antifungals were not able to impact the mature biofilm parameters (biomass and viability). Additionally, the S. cerevisiae strain caused the death of Tenebrio molitor larvae, depending on the fungal inoculum, and larvae immunosuppression with corticosteroids increased the larvae mortality rate. In conclusion, the present study highlighted the emergence of S. cerevisiae as an opportunistic fungal pathogen in immunosuppressed patients presenting several severe comorbidities, including COVID-19 infection.

Published
2023
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254. Menopause and Ageing

Author

Caretto, Marta, Giannini, Andrea, Simoncini, Tommaso, Genazzani, Andrea R., Schenker, Joseph G., Series Editor, Sciarra, John J., Series Editor, Mettler, Liselotte, Series Editor, Genazzani, Andrea R., Series Editor, and Birkhaeuser, Martin, Series Editor

Published
2018
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261. A phase I study of intravenous or intraperitoneal platinum based chemotherapy in combination with veliparib and bevacizumab in newly diagnosed ovarian, primary peritoneal and fallopian tube cancer

Author

Moore, Kathleen N., Miller, Austin, Bell-McGuinn, Katherine M., Schilder, Russell J., Walker, Joan L., O’Cearbhaill, Roisin E., Guntupalli, Saketh R., Armstrong, Deborah K., Hagemann, Andrea R., Gray, Heidi J., Duska, Linda R., Mathews, Cara A., Chen, Alice, O’Malley, David, Gordon, Sarah, Fracasso, Paula M., and Aghajanian, Carol

Published
2020
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267. COVID-19 Exposure, Stress, and Mental Health Outcomes: Results From a Needs Assessment Among Low Income Adults in Central North Carolina

Author

Andréa R. Kaniuka, Robert J. Cramer, Corrine N. Wilsey, Jennifer Langhinrichsen-Rohling, Annelise Mennicke, Alexandra Patton, Meagan Zarwell, Carmen P. McLean, Yu-Jay Harris, Sharon Sullivan, and Glori Gray

Subjects
COVID-19, coping, stress, mental health, suicide, Psychiatry, RC435-571
Abstract

This study focuses on identifying COVID-19 related exposure, stress, and mental health concerns in the larger Charlotte, North Carolina region, an area with many low-income and under resourced communities. A community-academic partnership conducted a regional COVID-19 needs assessment. Low-income adults (N = 156) completed an online-administered survey of demographic information, COVID-19 exposure, stress, coping-related factors, and mental health. Frequency data showed that common COVID-19 related stressors included job exposure, lost job/income, and increased home responsibilities. Frequency data further showed elevated screening risk rates for mental health concerns were observed for post-traumatic stress (83.3%), depression (52.2%), problematic drinking (50.0%), generalized anxiety (43.0%), and suicide (40.4%). Bivariate correlation and multivariate regression models identified robust mental health risk factors including COVID-19 related stress affecting close persons, fear/worry reaction to the pandemic, and use of venting as a coping strategy; protective factors included active coping and problem-focused coping beliefs. Findings are discussed with respect to informing regional public health efforts during the pandemic.

Published
2022
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268. Almost critical well-posedness for nonlinear wave equation with $Q_{\mu\nu}$ null forms in 2D

Author

Grigoryan, Viktor and Nahmod, Andrea R.

Subjects
Mathematics - Analysis of PDEs, 35L70
Abstract

In this paper we prove an optimal local well-posedness result for the 1+2 dimensional system of nonlinear wave equations (NLW) with quadratic null-form derivative nonlinearities $Q_{\mu\nu}$. The Cauchy problem for these equations is known to be ill-possed for data in the Sobolev space $H^s$ with $s<5/4$ for all the basic null-forms, except $Q_0$. However, the scaling analysis predicts local well-posedness all the way to the critical regularity of $s_c=1$. Following Gr\"{u}nrock's result for the quadratic derivative NLW, we consider initial data in the Fourier-Lebesgue spaces $\^{H}_s^r$, which coincide with the Sobolev spaces of the same regularity for $r=2$, but scale like lower regularity Sobolev spaces for $11+{1}{r}$, $1

Published
2013

269. High-Throughput Mapping of B Cell Receptor Sequences to Antigen Specificity

Author

Setliff, Ian, Shiakolas, Andrea R., Pilewski, Kelsey A., Murji, Amyn A., Mapengo, Rutendo E., Janowska, Katarzyna, Richardson, Simone, Oosthuysen, Charissa, Raju, Nagarajan, Ronsard, Larance, Kanekiyo, Masaru, Qin, Juliana S., Kramer, Kevin J., Greenplate, Allison R., McDonnell, Wyatt J., Graham, Barney S., Connors, Mark, Lingwood, Daniel, Acharya, Priyamvada, Morris, Lynn, and Georgiev, Ivelin S.

Published
2019
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291. Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Author

Krebs, Shelly J., Kwon, Young D., Schramm, Chaim A., Law, William H., Donofrio, Gina, Zhou, Kenneth H., Gift, Syna, Dussupt, Vincent, Georgiev, Ivelin S., Schätzle, Sebastian, McDaniel, Jonathan R., Lai, Yen-Ting, Sastry, Mallika, Zhang, Baoshan, Jarosinski, Marissa C., Ransier, Amy, Chenine, Agnes L., Asokan, Mangaiarkarasi, Bailer, Robert T., Bose, Meera, Cagigi, Alberto, Cale, Evan M., Chuang, Gwo-Yu, Darko, Samuel, Driscoll, Jefferson I., Druz, Aliaksandr, Gorman, Jason, Laboune, Farida, Louder, Mark K., McKee, Krisha, Mendez, Letzibeth, Moody, M. Anthony, O’Sullivan, Anne Marie, Owen, Christopher, Peng, Dongjun, Rawi, Reda, Sanders-Buell, Eric, Shen, Chen-Hsiang, Shiakolas, Andrea R., Stephens, Tyler, Tsybovsky, Yaroslav, Tucker, Courtney, Verardi, Raffaello, Wang, Keyun, Zhou, Jing, Zhou, Tongqing, Georgiou, George, Alam, S. Munir, Haynes, Barton F., Rolland, Morgane, Matyas, Gary R., Polonis, Victoria R., McDermott, Adrian B., Douek, Daniel C., Shapiro, Lawrence, Tovanabutra, Sodsai, Michael, Nelson L., Mascola, John R., Robb, Merlin L., Kwong, Peter D., and Doria-Rose, Nicole A.

Published
2019
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294. Auto-regulation of Secretory Flux by Sensing and Responding to the Folded Cargo Protein Load in the Endoplasmic Reticulum

Author

Subramanian, Advait, Capalbo, Anita, Iyengar, Namrata Ravi, Rizzo, Riccardo, di Campli, Antonella, Di Martino, Rosaria, Lo Monte, Matteo, Beccari, Andrea R., Yerudkar, Amol, del Vecchio, Carmen, Glielmo, Luigi, Turacchio, Gabriele, Pirozzi, Marinella, Kim, Sang Geon, Henklein, Petra, Cancino, Jorge, Parashuraman, Seetharaman, Diviani, Dario, Fanelli, Francesca, Sallese, Michele, and Luini, Alberto

Published
2019
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295. A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease

Author

Bellair, Michelle, Dinh, Huyen, Doddapeneni, Harsha, Dugan-Perez, Shannon, English, Adam, Gibbs, Richard A., Han, Yi, Hu, Jianhong, Jayaseelan, Joy, Kalra, Divya, Khan, Ziad, Korchina, Viktoriya, Lee, Sandra, Liu, Yue, Liu, Xiuping, Muzny, Donna, Nasser, Waleed, Salerno, William, Santibanez, Jireh, Skinner, Evette, White, Simon, Worley, Kim, Zhu, Yiming, Beiser, Alexa, Chen, Yuning, Chung, Jaeyoon, Cupples, L. Adrienne, DeStefano, Anita, Dupuis, Josee, Farrell, John, Farrer, Lindsay, Lancour, Daniel, Lin, Honghuang, Liu, Ching Ti, Lunetta, Kathy, Ma, Yiyi, Patel, Devanshi, Sarnowski, Chloe, Satizabal, Claudia, Seshadri, Sudha, Sun, Fangui Jenny, Zhang, Xiaoling, Choi, Seung Hoan, Banks, Eric, Gabriel, Stacey, Gupta, Namrata, Bush, William, Butkiewicz, Mariusz, Haines, Jonathan, Smieszek, Sandra, Song, Yeunjoo, Barral, Sandra, De Jager, Phillip L., Mayeux, Richard, Reitz, Christiane, Reyes, Dolly, Tosto, Giuseppe, Vardarajan, Badri, Amad, Shahzad, Amin, Najaf, Ikram, M. Afran, van der Lee, Sven, van Duijn, Cornelia, Vanderspek, Ashley, Schmidt, Helena, Schmidt, Reinhold, Goate, Alison, Kapoor, Manav, Marcora, Edoardo, Renton, Alan, Faber, Kelley, Foroud, Tatiana, Feolo, Michael, Stine, Adam, Launer, Lenore J., Bennett, David A., Xia, Li Charlie, Beecham, Gary, Hamilton-Nelson, Kara, Jaworski, James, Kunkle, Brian, Martin, Eden, Pericak-Vance, Margaret, Rajabli, Farid, Schmidt, Michael, Mosley, Thomas H., Cantwell, Laura, Childress, Micah, Chou, Yi-Fan, Cweibel, Rebecca, Gangadharan, Prabhakaran, Kuzma, Amanda, Leung, Yuk Yee, Lin, Han-Jen, Malamon, John, Mlynarski, Elisabeth, Naj, Adam, Qu, Liming, Schellenberg, Gerard, Valladares, Otto, Wang, Li-San, Wang, Weixin, Zhang, Nancy, Below, Jennifer E., Boerwinkle, Eric, Bressler, Jan, Fornage, Myriam, Jian, Xueqiu, Liu, Xiaoming, Bis, Joshua C., Blue, Elizabeth, Brown, Lisa, Day, Tyler, Dorschner, Michael, Horimoto, Andrea R., Nafikov, Rafael, Nato, Alejandro Q., Jr., Navas, Pat, Nguyen, Hiep, Psaty, Bruce, Rice, Kenneth, Saad, Mohamad, Sohi, Harkirat, Thornton, Timothy, Tsuang, Debby, Wang, Bowen, Wijsman, Ellen, Witten, Daniela, Antonacci-Fulton, Lucinda, Appelbaum, Elizabeth, Cruchaga, Carlos, Fulton, Robert S., Koboldt, Daniel C., Larson, David E., Waligorski, Jason, Wilson, Richard K., Zhu, Congcong, Vardarajan, Badri N., Farrell, John J., Haines, Jonathan L., Schellenberg, Gerard D., Pericak-Vance, Margaret A., Lunetta, Kathryn L., and Farrer, Lindsay A.

Published
2019
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299. Almost sure existence of global weak solutions for super-critical Navier-Stokes equations

Author

Nahmod, Andrea R., Pavlović, Nataša, and Staffilani, Gigliola

Subjects
Mathematics - Analysis of PDEs
Abstract

In this paper we show that after suitable data randomization there exists a large set of super-critical periodic initial data, in $H^{-\alpha}({\mathbb T}^d)$ for some $\alpha(d) > 0$, for both 2d and 3d Navier-Stokes equations for which global energy bounds are proved. As a consequence, we obtain almost sure super-critical global weak solutions. We also show that in 2d these global weak solutions are unique., Comment: 22 pages, a revised argument in Section 5, the $d=3$ case

Published
2012

300. Absolute continuity of Brownian bridges under certain gauge transformations

Author

Nahmod, Andrea R., Rey-Bellet, Luc, Sheffield, Scott, and Staffilani, Gigliola

Subjects
Mathematics - Analysis of PDEs, Mathematics - Classical Analysis and ODEs, Mathematics - Probability
Abstract

We prove absolute continuity of Gaussian measures associated to complex Brownian bridges under certain gauge transformations. As an application we prove that the invariant measure for the periodic derivative nonlinear Schr\"odinger equation obtained by Nahmod, Oh, Rey-Bellet and Staffilani in [20], and with respect to which they proved almost surely global well-posedness, coincides with the weighted Wiener measure constructed by Thomann and Tzvetkov [24]. Thus, in particular we prove the invariance of the measure constructed in [24]., Comment: 12 pages. Submitted

Published
2011

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