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252. How does social environment of community neighborhood influence residents' physical exercise behavior:An empirical analysis based on the perspective of dual-process model.

Author

GUO Wen, LIU Yang, MENG Xiaokang, and ZHENG Lan

Abstract

Based on the dual-process models, 3 896 community residents were investigated to explore the effecting process mechanism of community neighborhood social environment (CNSE) on residents' exercise behavior from the perspective of exercise emotion. The results showed that: CNSE had a significant and positive effect on residents' physical exercise behavior; harmonious passion had a partial mediating effect on the relationship between CNSE and residents' physical exercise behavior, but the mediating effect of obsessive passion was not significant; exercise identity had a positive moderating effect between CNSE and residents' harmonious passion and obsessive passion; CNSE effected residents' exercise behavior through harmonious passion, rather than obsessive passion, which was moderated by exercise identity that acted as a mediated-moderator. This study expanded the mediating mechanism and boundary conditions of CNSE on residents' physical exercise behavior, suggesting that while improving the overall CNSE, communities needed to create a positive and active exercise climate to strengthen their exercise identity, thereby enhancing residents' harmonious passion in order to further promote their participation in physical exercise in daily life. [ABSTRACT FROM AUTHOR]

Published
2023

253. Regular Exercise Modulates the dfoxo / dsrebp Pathway to Alleviate High-Fat-Diet-Induced Obesity and Cardiac Dysfunction in Drosophila.

Author

Yan, Hanhui, Ding, Meng, Peng, Tianhang, Zhang, Ping, Tian, Rui, and Zheng, Lan

Subjects
HEART diseases, DROSOPHILA, HIGH-fat diet, HEART beat, OBESITY, WEIGHT gain, MOLECULAR switches
Abstract

Obesity is a prevalent metabolic disorder associated with various diseases, including cardiovascular conditions. While exercise is recognized as an effective approach for preventing and treating obesity, its underlying molecular mechanisms remain unclear. This study aimed to explore the impact of regular exercise on high-fat-diet-induced obesity and cardiac dysfunction in Drosophila, shedding light on its molecular mechanisms by identifying its regulation of the dfoxo and dsrebp signaling pathways. Our findings demonstrated that a high-fat diet leads to weight gain, fat accumulation, reduced climbing performance, and elevated triglyceride levels in Drosophila. Additionally, cardiac microfilaments in these flies exhibited irregularities, breakages, and shortening. M-mode analysis revealed that high-fat-diet-fed Drosophila displayed increased heart rates, shortened cardiac cycles, decreased systolic intervals, heightened arrhythmia indices, reduced diastolic diameters, and diminished fractional shortening. Remarkably, regular exercise effectively ameliorated these adverse outcomes. Further analysis showed that regular exercise reduced fat synthesis, promoted lipolysis, and mitigated high-fat-diet-induced cardiac dysfunction in Drosophila. These results suggest that regular exercise may mitigate high-fat-diet-induced obesity and cardiac dysfunction in Drosophila by regulating the dfoxo and dsrebp signaling pathways, offering valuable insights into the mechanisms underlying the beneficial effects of exercise on obesity and cardiac dysfunction induced by a high-fat diet. [ABSTRACT FROM AUTHOR]

Published
2023
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254. Interfacial Synergy between the Cu Atomic Layer and CeO2 Promotes CO Electrocoupling to Acetate

Author

Yang, Tang, primary, Lin, Li, additional, Lv, Ximeng, additional, Yang, Hongcen, additional, Feng, Huishu, additional, Huang, Zhongliang, additional, Li, Jiwei, additional, Pao, Chih-Wen, additional, Hu, Zhiwei, additional, Zhan, Changhong, additional, Xu, Yong, additional, Zheng, Lan-Sun, additional, Jiao, Feng, additional, and Huang, Xiaoqing, additional

Published
2023
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258. Supplementary Video 4 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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259. Supplementary Video 1 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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260. Supplementary Figure 5 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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261. Supplementary Tables 1 - 2 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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262. Supplementary Video 3 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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263. Supplementary Figure Legend from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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264. Supplementary Figure 2 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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265. Supplementary Video 2 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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266. Supplementary Figure 1 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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267. Supplementary Figure 4 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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268. Supplementary Figure 6 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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269. Supplementary Video Legend from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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270. Data from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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271. Supplementary Figure 3 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer

Author

Hu, Xiaowen, primary, Guo, Jinyi, primary, Zheng, Lan, primary, Li, Chunsheng, primary, Zheng, Tim M., primary, Tanyi, Janos L., primary, Liang, Shun, primary, Benedetto, Chiara, primary, Mitidieri, Marco, primary, Katsaros, Dionyssios, primary, Zhao, Xia, primary, Zhang, Youcheng, primary, Huang, Qihong, primary, and Zhang, Lin, primary

Published
2023
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272. Conflict Disclosure from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Author

He, Xiao-yan, primary, Tan, Zheng-lan, primary, Mou, Qin, primary, Liu, Fang-jie, primary, Liu, Shan, primary, Yu, Chao-wen, primary, Zhu, Jin, primary, Lv, Lin-ya, primary, Zhang, Jun, primary, Wang, Shan, primary, Bao, Li-ming, primary, Peng, Bin, primary, Zhao, Hui, primary, and Zou, Lin, primary

Published
2023
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273. Supplementary table 3 from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Author

He, Xiao-yan, primary, Tan, Zheng-lan, primary, Mou, Qin, primary, Liu, Fang-jie, primary, Liu, Shan, primary, Yu, Chao-wen, primary, Zhu, Jin, primary, Lv, Lin-ya, primary, Zhang, Jun, primary, Wang, Shan, primary, Bao, Li-ming, primary, Peng, Bin, primary, Zhao, Hui, primary, and Zou, Lin, primary

Published
2023
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274. Copyright Transfer from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Author

He, Xiao-yan, primary, Tan, Zheng-lan, primary, Mou, Qin, primary, Liu, Fang-jie, primary, Liu, Shan, primary, Yu, Chao-wen, primary, Zhu, Jin, primary, Lv, Lin-ya, primary, Zhang, Jun, primary, Wang, Shan, primary, Bao, Li-ming, primary, Peng, Bin, primary, Zhao, Hui, primary, and Zou, Lin, primary

Published
2023
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275. Contribution Form from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Author

He, Xiao-yan, primary, Tan, Zheng-lan, primary, Mou, Qin, primary, Liu, Fang-jie, primary, Liu, Shan, primary, Yu, Chao-wen, primary, Zhu, Jin, primary, Lv, Lin-ya, primary, Zhang, Jun, primary, Wang, Shan, primary, Bao, Li-ming, primary, Peng, Bin, primary, Zhao, Hui, primary, and Zou, Lin, primary

Published
2023
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276. Supplementary figure 2 from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Author

He, Xiao-yan, primary, Tan, Zheng-lan, primary, Mou, Qin, primary, Liu, Fang-jie, primary, Liu, Shan, primary, Yu, Chao-wen, primary, Zhu, Jin, primary, Lv, Lin-ya, primary, Zhang, Jun, primary, Wang, Shan, primary, Bao, Li-ming, primary, Peng, Bin, primary, Zhao, Hui, primary, and Zou, Lin, primary

Published
2023
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280. Nobiletin inhibits breast cancer cell migration and invasion by suppressing the IL-6-induced ERK-STAT and JNK-c-JUN pathways

Author

Wu, Yuan, primary, Li, Qiong, additional, Lv, Ling-ling, additional, Chen, Jing-xian, additional, Ying, Hai-feng, additional, Ruan, Ming, additional, Zhu, Wen-hua, additional, Xu, Jia-yue, additional, Zhang, Chen-yiyu, additional, Zhang, Kai-yuan, additional, Guo, Yuan-biao, additional, Zhu, Wei-rong, additional, and Zheng, Lan, additional

Published
2023
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296. Data from microRNA-221 Enhances MYCN via Targeting Nemo-like Kinase and Functions as an Oncogene Related to Poor Prognosis in Neuroblastoma

Author

Lin Zou, Hui Zhao, Bin Peng, Li-ming Bao, Shan Wang, Jun Zhang, Lin-ya Lv, Jin Zhu, Chao-wen Yu, Shan Liu, Fang-jie Liu, Qin Mou, Zheng-lan Tan, and Xiao-yan He

Abstract

Purpose:MYCN is one of the most well-characterized genetic markers of neuroblastoma. However, the mechanisms as to how MYCN mediate neuroblastoma tumorigenesis are not fully clear. Increasing evidence has confirmed that the dysregulation of miRNAs is involved in MYCN-mediated neuroblastoma tumorigenesis, supporting their potential as therapeutic targets for neuroblastoma. Although miR-221 has been reported as one of the upregulated miRNAs, the interplay between miR-221 and MYCN-mediated neuroblastoma progression remains largely elusive.Experimental Design: The expression of miR-221 in the formalin-fixed, paraffin-embedded tissues from 31 confirmed patients with neuroblastoma was detected by locked nucleic acid-in situ hybridization and qRT-PCR. The correlation between miR-221 expression and clinical features in patients with neuroblastoma was assessed. The mechanisms as to how miR-221 regulate MYCN in neuroblastoma were addressed. The effect of miR-221 on cellular proliferation in neuroblastoma was determined both in vitro and in vivo.Results: miR-221 was significantly upregulated in neuroblastoma tumor cells and tissues that overexpress MYCN, and high expression of miR-221 was positively associated with poor survival in patients with neuroblastoma. Nemo-like kinase (NLK) as a direct target of miR-221 in neuroblastoma was verified. In addition, overexpression of miR-221 decreased LEF1 phosphorylation but increased the expression of MYCN via targeting of NLK and further regulated cell cycle, particularly in S-phase, promoting the growth of neuroblastoma cells.Conclusions: This study provides a novel insight for miR-221 in the control of neuroblastoma cell proliferation and tumorigenesis, suggesting potentials of miR-221 as a prognosis marker and therapeutic target for patients with MYCN overexpressing neuroblastoma. Clin Cancer Res; 23(11); 2905–18. ©2016 AACR.

Published
2023

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