251. Pharmacochemistry and integrated pharmacokinetics of six alkaloids after oral administration of huang-lian-jie-du-tang decoction
- Author
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Jian-Xun Liu, Xiu-Wei Yang, Zhao-Tang Ma, and Ying Zhang
- Subjects
Coptisine ,Jatrorrhizine ,Iridoid ,Berberine ,medicine.drug_class ,Berberine Alkaloids ,Pharmaceutical Science ,Administration, Oral ,Decoction ,Pharmacology ,Analytical Chemistry ,Rats, Sprague-Dawley ,chemistry.chemical_compound ,Alkaloids ,Glucosides ,Drug Discovery ,medicine ,Animals ,heterocyclic compounds ,Iridoids ,Chromatography, High Pressure Liquid ,Flavonoids ,Traditional medicine ,biology ,Molecular Structure ,Organic Chemistry ,Palmatine ,General Medicine ,Coptis chinensis ,biology.organism_classification ,Rats ,Complementary and alternative medicine ,chemistry ,Flavanones ,Molecular Medicine ,Baicalin ,Drugs, Chinese Herbal - Abstract
Pharmacochemistry and integrated pharmacokinetics of six alkaloids (groenlandicine, berberine, palmatine, epiberberine, jatrorrhizine, and columbamine) after oral administration of Huang-Lian-Jie-Du-Tang (HLJDT) decoction were investigated in this paper. The method of plasma pharmacochemistry was applied to predict the potential bioactive components in HLJDT decoction. Based on the accurate molecular weight, 10 components including 2 flavonoids (baicalin and wogonoside), 1 iridoid glycoside (geniposide), and 7 alkaloids (above-mentioned 6 alkaloids and coptisine) were structurally identified. Then, integrated pharmacokinetics of the alkaloids in Sprague-Dawley rats after oral administration of HLJDT decoction was investigated by HPLC method. The results showed that the pharmacokinetic behaviors of the alkaloids were different although their chemical structures were similar. This study developed a method to predict the potential bioactive components in HLJDT decoction and research the pharmacokinetic behaviors of the potential bioactive components.
- Published
- 2014