39,463 results on '"YANG, W."'
Search Results
252. IDF23-0286 Efficacy and safety of GL insulin aspart 70/30 compared with reference insulin in Chinese patients with DM
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Wang, X., primary, Yang, W., additional, Li, Q., additional, Shi, Y., additional, Liu, J., additional, and Mo, Z., additional
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- 2024
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- View/download PDF
253. Fewer Well with Higher Production Pattern Development of Metamorphic Reservoirs
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Chen, M. Q., He, J., Ren, L., Yang, W. B., Wu, Wei, Series Editor, and Lin, Jia'en, editor
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- 2020
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254. Numerical Study of Surface Regression of a Flame Retarded Expandable Polystrene
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Yuen, A. C. Y., Yang, W., Yeoh, G. H., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Ho, Johnny C.M., editor, and Kitipornchai, Sritawat, editor
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- 2020
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255. Prevalence and Associated Factors of Kidney Dysfunction in Patients with Hypertension and/or Diabetes Mellitus from a Primary Care Population in Northwest China
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Lin M, Heizhati M, Wang L, Gan L, Li M, Yang W, Yao L, Wang Z, Yang Z, Abudoyreyimu R, Wu Z, and Li N
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kidney dysfunction ,hypertension ,diabetes ,epidemiology ,Medicine (General) ,R5-920 - Abstract
Mengyue Lin,1,2 Mulalibieke Heizhati,2 Lin Wang,2 Lin Gan,1,2 Mei Li,2 Wenbo Yang,2 Ling Yao,2 Zhongrong Wang,2 Zhikang Yang,2 Reyila Abudoyreyimu,2 Zihao Wu,2 Nanfang Li1,2 1Xinjiang Medical University, Urumqi, People’s Republic of China; 2Hypertension Center of the People’s Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang, People’s Republic of ChinaCorrespondence: Nanfang LiHypertension Center of People’s Hospital of Xinjiang Uygur Autonomous Region; Xinjiang Hypertension Institute; National Health Committee Key Laboratory of Hypertension Clinical Research, 91 Tianchi Road, Urumqi, Xinjiang, 830001, People’s Republic of ChinaEmail lnanfang2016@sina.comPurpose: The burden of kidney dysfunction (KD) is rapidly increasing in developing countries due to an ongoing epidemic of hypertension and diabetes. We aimed to evaluate the prevalence and associated factors of KD among population with hypertension and/or diabetes from primary care setting.Methods: This study was part of a cross-sectional study conducted in Northwest China, which aimed to investigate the epidemiological status of hypertension and other chronic noninfectious diseases. Subjects aged ≥ 18 years old with hypertension and/or diabetes were included in this study. KD was defined as estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2. Least absolute shrinkage and selection operator and multivariable logistic regression were used to identify factors associated with KD. Sensitivity analysis was performed by comparing the results of different estimated equations for GFR.Results: A total of 8899 participants with hypertension and/or diabetes were included. Prevalence of KD was 8.69% (n=144) among patients with both hypertension and DM, 3.36% (n=198) among patients with only hypertension, and 5.22% (n=70) among patients with only diabetes. Women showed higher prevalent KD than men. Modifiable factors independently associated with KD among patients with hypertension and/or diabetes included physical activity, duration of hypertension or DM, anemia, fasting plasma glucose and triglyceride. Results of different estimated equations showed similar trends of difference in the prevalence of KD among groups.Conclusion: KD is common in patients with hypertension and/or DM in Northwest China. More attention should be paid to high-risk patients, especially to those with co-existence of hypertension and DM. Control of blood glucose and triglyceride may further improve KD management in this patient population.Keywords: kidney dysfunction, hypertension, diabetes, epidemiology
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- 2021
256. Direct-on-Target Microdroplet Growth Assay for Detection of Bacterial Resistance in Positive Blood Cultures
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Tang H, Li R, Xu H, Lu G, Liu Z, Yang W, Xia Z, Zhu Y, and Shen J
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maldi-tof ,dot-mga ,rapid antimicrobial susceptibility testing ,blood culture ,antibiotic resistance ,direct-from-bc disk-diffusion method ,Infectious and parasitic diseases ,RC109-216 - Abstract
Hao Tang,1 Rongrong Li,2 Huaming Xu,1 Guoping Lu,3 Zhen Liu,1 Wensu Yang,1 Zhaoxin Xia,1 Yi Zhu,1 Jilu Shen1 1The Fourth Affiliated Hospital of Anhui Medical University Laboratory Department, Hefei, People’s Republic of China; 2The First Affiliated Hospital of Anhui Medical University Laboratory Department, Hefei, People’s Republic of China; 3Laboratory Department of Fuyang Hospital Affiliated to Anhui Medical University, Fuyang, Anhui, 236000, People’s Republic of ChinaCorrespondence: Jilu ShenThe Fourth Affiliated Hospital of Anhui Medical University Laboratory, No. 100 Huaihai Avenue, Xinzhan District, Hefei, Anhui Province, 230012, People’s Republic of ChinaTel +86 151 5515 2963Email shenjilu@ahmu.edu.cnIntroduction: The recently developed DOT-MGA (direct-on-target microdroplet growth assay) has shown the desirability of direct application of this approach in positive blood cultures and its good performance in detection. This study selected 44 Enterobacteriaceae strains and implemented a DOT-MGA assay on blood cultures to detect their resistance to seven antibiotics. The results of DOT-MGA were compared with the other two antimicrobial susceptibility testing (AST) methods to analyze the detection performance of DOT-MGA.Methods: We adopted the differential centrifugation to process positive blood-culture (BC). Processed BC broth was directly used for rapid AST using DOT-MGA. Droplets of 6 μL with and without antibiotics at the EUCAST breakpoint concentration were spotted in triplicates onto the surface of a MALDI target. The plates were incubated in a wet box for 4 h before the broth was removed with filter paper. Bruker Biotyper software was used to analyze the test results compared with standard database, and the scores were used to quantify and determine the results.Results: DOT-MGA results were compared with the direct-from-BC disk-diffusion method and results were reported by broth microdilution method, respectively. The comparison demonstrated a 100% growth efficiency in DOT-MGA, a 100% classification consistency for ampicillin, ceftriaxone, and gentamicin, and > 93% classification consistency for tobramycin, aztreonam, trimethoprim-sulfamethoxazole (TMP-SMX), and ceftazidime.Discussion: These study results have shown that DOT-MGA is suitable for directly identifying bacterial resistance to positive blood cultures in clinical microbiology laboratories. Furthermore, it is conducive for early diagnosis and treatment of patients with bloodstream infection due to its convenience, time efficiency, and good performance in identifying multiple antibiotic-insensitive bacteria.Keywords: MALDI-TOF, DOT-MGA, rapid antimicrobial susceptibility testing, blood culture, antibiotic resistance, direct-from-BC disk-diffusion method
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- 2021
257. Acarbose Reduces Low-Grade Albuminuria Compared to Metformin in Chinese Patients with Newly Diagnosed Type 2 Diabetes
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Song L, Kong X, Yang Z, Zhang J, Yang W, Zhang B, Chen X, and Wang X
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diabetes mellitus ,type 2 ,diabetic nephropathies ,hypoglycemic agents ,Specialties of internal medicine ,RC581-951 - Abstract
Lulu Song,1 Xiaomu Kong,2 Zhaojun Yang,1 Jinping Zhang,1 Wenying Yang,1 Bo Zhang,1 Xiaoping Chen,1 Xin Wang1 1Department of Endocrinology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Clinical Laboratory, China-Japan Friendship Hospital, Beijing, People’s Republic of ChinaCorrespondence: Xin WangDepartment of Endocrinology, China-Japan Friendship Hospital, 2 Yinghua East Road, Beijing, 100029, People’s Republic of ChinaTel +86 1084205254Email xiangpian11@163.comPurpose: To assess the effect of acarbose in lowering low-grade albuminuria compared to metformin in newly diagnosed Chinese type 2 diabetes (T2DM) patients.Patients and Methods: The Metformin and AcaRbose Clinical Trial was a randomized, open-label trial in newly diagnosed T2DM patients. Participants received 48 weeks of monotherapy with acarbose (100 mg three times a day) or metformin (1500 mg once a day). As the hypoglycemic effect of acarbose and metformin has been evaluated in previous reports. This analysis studied the effect of the two antidiabetic drugs on reducing urinary albumin. The percent change in the urinary albumin/creatinine ratio (uACR) from baseline to week 48 was analyzed, and ANCOVA was employed to establish whether the effect in decreasing uACR was mediated by metabolic improvement.Results: Acarbose reduced the adjusted mean percent uACR by − 31.5% (95% confidence interval [CI] − 48.4 to − 7.5) compared with metformin. When adjusting for changes in glycated hemoglobin, body weight, systolic blood pressure and triglycerides or changes in area under the curve of glucagon-like peptide 1 (AUCGLP-1) in the standard meal test, the uACR-lowering effect was not attenuated. If stratified by eGFR, blood glucose level, sex or uACR level, the effect of acarbose versus metformin was consistent across subgroups. The proportion of patients with a reduction in uACR of at least 70% was 48.6% in the acarbose group and 34.1% in the metformin group.Conclusion: Acarbose lowered the uACR compared to metformin in newly diagnosed T2DM patients independent of improvements in hyperglycemia, blood pressure, body weight and triglycerides.Keywords: diabetes mellitus, type 2, diabetic nephropathies, hypoglycemic agents
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- 2021
258. Subjective Poor Sleep Quality is Associated with Higher Blood Pressure and Prevalent Hypertension in General Population Independent of Sleep Disordered Breathing
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Yang Z, Heizhati M, Wang L, Li M, Pan F, Wang Z, Abudureyimu R, Hong J, Yao L, Yang W, Liu S, and Li N
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sleep quality ,sleep disordered breathing ,blood pressure ,prevalent hypertension ,Psychiatry ,RC435-571 ,Neurophysiology and neuropsychology ,QP351-495 - Abstract
Zhikang Yang,1– 3,* Mulalibieke Heizhati,1– 3,* Lin Wang,1– 3 Mei Li,1– 3 Fengyu Pan,1– 3 Zhongrong Wang,1– 3 Reyila Abudureyimu,1– 3 Jing Hong,1– 3 Ling Yao,1– 3 Wenbo Yang,1– 3 Shasha Liu,1– 3 Nanfang Li1– 3 1Hypertension Center, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, People’s Republic of China; 2Xinjiang Hypertension Institute, Urumqi, Xinjiang, People’s Republic of China; 3National Health Committee Key Laboratory of Hypertension Clinical Research, Urumqi, Xinjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nanfang Li Email Lnanfang2016@sina.comObjective: To explore the relationship of subjective sleep quality with blood pressure (BP) and hypertension by considering the influence of sleep disordered breathing (SDB) and age in the general population.Methods: We evaluated sleep quality using the Pittsburgh sleep quality index (PSQI) and SDB using NoSAS score and measured BP in randomly selected adults in China in 2019. Sleep quality is categorized into four groups as very good, fairly good, fairly bad and very bad. SDB is defined as NoSAS score ≥ 8. Hypertension is defined as systolic BP ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg, and/or use of antihypertensive medicine within previous 2 weeks. Multi-variable linear and logistic regression analyses were used to assess the association of global PSQI score and sleep quality with BP and prevalent hypertension.Results: In the 33,341 participants (53.4% women, median age: 48 years), prevalence of hypertension significantly increased from very good to very bad sleepers in total (34.3 vs 42.6 vs 50.3 vs 58.5%), SDB (61.2 vs 68.3 vs 73.3 vs 75.5%) and non-SDB participants (26.8 vs 33.1 vs 40.1 vs 50.9%). In multiple linear regression, PSQI global score showed significant positive association with BP levels in total, SDB and non-SDB participants, consistent in sensitivity analysis by excluding participants who were taking antihypertensives, and in participants aged < 60 years in age-stratified analysis. In multivariable logistic regression, odds ratio for presence of hypertension significantly increased from very good to very bad sleepers in total (1 vs 1.08 vs 1.22 vs 1.48), SDB (1 vs 1.17 vs 1.35 vs 1.28) and non-SDB participants (1 vs 1.05 vs 1.14 vs 1.53), consistent in participants aged < 60 years.Conclusion: Poor subjective sleep quality is significantly associated with higher BP and prevalent hypertension, independent of SDB in the young- and middle-aged general population, indicating potential of improving sleep quality to lower BP and optimize hypertension management at population level.Keywords: sleep quality, sleep disordered breathing, blood pressure, prevalent hypertension
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- 2021
259. The Jieduan-Niwan (JDNW) Formula Ameliorates Hepatocyte Apoptosis: A Study of the Inhibition of E2F1-Mediated Apoptosis Signaling Pathways in Acute-on-Chronic Liver Failure (ACLF) Using Rats
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Hou W, Hao Y, Yang W, Tian T, Fang P, Du Y, Gao L, Gao Y, and Zhang Q
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traditional chinese medicine ,apoptosis ,jieduan-niwan formula ,acute-on-chronic liver failure rat model ,e2f1 ,pharmacological effect ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Weixin Hou,1– 4 Yulin Hao,1,2 Wenlong Yang,1,2 Tian Tian,1,2 Peng Fang,1,2 Yuqiong Du,1,2 Lianyin Gao,1,2 Yanbin Gao,3,4 Qiuyun Zhang1,2 1Department of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 2Department of Hepatology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of China; 3Department of Endocrinology, School of Traditional Chinese Medicine, Capital Medical University, Beijing, People’s Republic of China; 4Department of Endocrinology, Beijing Key Laboratory of Traditional Chinese Medicine Collateral Disease Theory Research, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Qiuyun ZhangDepartment of Hepatology, School of Traditional Chinese Medicine, Capital Medical University, No. 10 You An Men Wai, Xi Tou Tiao, Feng Tai District, Beijing, 100069, People’s Republic of ChinaTel +86 10 8391 1638Email 19970059@ccmu.edu.cnYanbin GaoDepartment of Endocrinology, School of Traditional Chinese Medicine, Capital Medical University, No. 10 You An Men Wai, Xi Tou Tiao, Feng Tai District, Beijing, 100069, People’s Republic of ChinaTel +86 10 8391 1720Email gyb@ccmu.edu.cnBackground: Acute-on-chronic liver failure (ACLF) is a severe, complicated human disease. E2F1-mediated apoptosis plays an important role in ACLF development. Jieduan-Niwan (JDNW) formula, a traditional Chinese medicine (TCM), has shown remarkable clinical efficacy in ACLF treatment. However, the hepatoprotective mechanisms of the formula are barely understood.Purpose: This study aimed to investigate the mechanisms of JDNW formula in ACLF treatment by specifically regulating E2F1-mediated apoptotic signaling pathways in rats.Methods: The JDNW components were determined by high-performance liquid chromatography (HPLC) analysis. The ACLF rat model was established using human serum albumin immune-induced liver cirrhosis, followed by D-galactosamine and lipopolysaccharide joint acute attacks. The ACLF rat was treated with JDNW formula. Prothrombin time activity was measured to investigate the coagulation function. Liver pathological injury was observed by hematoxylin-eosin (HE) and reticular fiber staining. The hepatocyte apoptosis index and apoptosis rate were determined by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay and flow cytometry, respectively. Additionally, the expression of key genes and proteins that regulate E2F1-mediated apoptosis was analyzed by quantitative real-time PCR and Western blot.Results: Seven major components of JDNW formula were detected. The formula ameliorated the coagulation function, decreased the hepatocyte apoptosis index and apoptosis rate, and alleviated liver pathological damage in ACLF rats. The down-regulation of the expression of genes and proteins from p53-dependent and non-p53-dependent apoptosis pathways and the up-regulation of the expression of genes from blocking anti-apoptotic signaling pathways indicated that JDNW formula inhibited excessive hepatocyte apoptosis in ACLF rats via E2F1-mediated apoptosis signaling pathways.Conclusion: The findings indicate that JDNW formula protects livers of ACLF rats by inhibiting E2F1-mediated apoptotic signaling pathways, implying that these pathways might be a potential therapeutic target for ACLF treatment.Keywords: traditional Chinese medicine, apoptosis, Jieduan-Niwan formula, acute-on-chronic liver failure rat model, E2F1, pharmacological effect
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- 2021
260. Metabolic Processes are Potential Biological Processes Distinguishing Nonischemic Dilated Cardiomyopathy from Ischemic Cardiomyopathy: A Clue from Serum Proteomics
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Huang G, Huang Z, Peng Y, Wang Y, Liu W, Xue Y, and Yang W
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proteomics ,ischemic cardiomyopathy ,dilated cardiomyopathy ,weighted gene co-expression network analysis ,gene set enrichment analysis ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Guangyong Huang,1 Zhiqi Huang,2 Yunling Peng,1 Yuehai Wang,1 Weitao Liu,1 Yuzeng Xue,1 Wenbo Yang3 1Department of Cardiology, Liaocheng People’s Hospital of Shandong University, Liaocheng, People’s Republic of China; 2Department of Geriatric Medicine, Civil Aviation General Hospital, Beijing, People’s Republic of China; 3Department of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence: Wenbo YangDepartment of Cardiovascular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaTel +86-21-64370045Fax +86-21-64457177Email yangwb_ywb@163.comBackground: Ischemic cardiomyopathy (ICM) and nonischemic dilated cardiomyopathy (DCM) are the two most common causes of heart failure. However, our understanding of the specific proteins and biological processes distinguishing DCM from ICM remains insufficient.Materials and Methods: The proteomics analyses were performed on serum samples from ICM (n=5), DCM (n=5), and control (n=5) groups. Proteomics and bioinformatics analyses, including weighted gene co-expression network analysis (WGCNA) and gene set enrichment analysis (GSEA), were performed to identify the hub circulating proteins and the hub biological processes in ICM and DCM.Results: The analysis of differentially expressed proteins and WGCNA identified the hub circulating proteins in ICM (GAPDH, CLSTN1, VH3, CP, and ST13) and DCM (one downregulated protein, FGG; 18 upregulated proteins, including HEL-S-276, IGK, ALDOB, HIST1H2BJ, HEL-S-125m, RPLP2, EL52, NCAM1, P4HB, HEL-S-99n, HIST1H4L, HIST2H3PS2, F8, ERP70, SORD, PSMA3, PSMB6, and PSMA6). The mRNA expression of the heart specimens from GDS651 validated that ALDOB, GAPDH, RPLP2, and IGK had good abilities to distinguish DCM from ICM. In addition, GSEA results showed that cell proliferation and differentiation were the hub biological processes related to ICM, while metabolic processes and cell signaling transduction were the hub biological processes associated with DCM.Conclusion: The present study identified five dysregulated hub circulating proteins among ICM patients and 19 dysregulated hub circulating proteins among DCM patients. Cell proliferation and differentiation were significantly enriched in ICM. Metabolic processes were strongly enhanced in DCM and may be used to distinguish DCM from ICM.Keywords: proteomics, ischemic cardiomyopathy, dilated cardiomyopathy, weighted gene co-expression network analysis, gene set enrichment analysis
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- 2021
261. Dual Growth Factor (rhTPO + G-CSF) and Chemotherapy Combination Regimen for Elderly Patients with Acute Myeloid Leukemia: A Phase II Single-Arm Multicenter Study
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Liu X, Shi H, Shen J, Li Y, Yan W, Sun Y, Liao A, Tan Y, Yang W, and Wang H
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rhtpo ,elderly ,acute myeloid leukemia ,cag ,decitabine ,Medicine (General) ,R5-920 - Abstract
Xiaoyu Liu,1 Hua Shi,2 Jing Shen,1 Yang Li,1 Wei Yan,1 Ying Sun,1 Aijun Liao,1 Yehui Tan,3 Wei Yang,1,* Huihan Wang1,* 1Haematology Department of Shengjing Hospital, China Medical University, Shenyang, Liaoning, 110004, People’s Republic of China; 2Haematology Department of Sun Yat-sen Memorial Hospital, Sun Yat-sen University Shen Shan Central Hospital, Guangzhou, People’s Republic of China; 3Haematology Department of The First Hospital of Jilin University, Changchun, Jilin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Yang; Huihan WangHaematology Department of Shengjing Hospital, China Medical University, Shenyang, Liaoning, 110004, People’s Republic of ChinaTel +86-18940251012; +86-18940256966Email yangw@sj-hospital.org; wanghh@sj-hospital.orgAbstract: Acute myeloid leukemia (AML) is a disease affecting older adults, although optimal strategies for treating such patients remain unclear. This prospective phase II, open-label, multicenter study was designed to assess the efficacy and safety of two hematologic growth factors, recombinant human thrombopoietin (rhTPO) and granulocyte colony-stimulating factor (G-CSF), in combination with decitabine, cytarabine, and aclarubicin (D-CTAG regimen) to treat older adults with newly diagnosed AML (Identifier: NCT04168138). The above agents were administered as follows: decitabine (15 mg/m2 daily, days 1– 5); low-dose cytarabine (10 mg/m2 q12 h, days 3– 9); rhTPO (15,000 U daily, days 2, 4, 6, 8, 10– 24 or until > 50× 109/L platelets); aclarubicin (14 mg/m2 daily, days 3– 6); and G-CSF (300 μg daily, days 2– 9). We concurrently monitored historic controls treated with decitabine followed by cytarabine, aclarubicin, and G-CSF (D-CAG) only. After the first D-CTAG cycle, the overall response rate (ORR) was 84.2% (16/19), including 13 (73.7%) complete remissions (CRs) and three (15.8%) partial remissions. This CR rate surpassed that of the D-CAG treatment (p < 0.05). Median overall survival (OS) time in the D-CTAG group was 20.2 months (range, 4– 31 months), compared with 14 months in the D-CAG group, and 1-year OS was 78%. The proportion of those experiencing grade III–IV thrombocytopenia was significantly lower for D-CTAG (57.9%) than for D-CAG (88.4%; p < 0.05). Ultimately, the curative effect of adding rhTPO was not inferior to that of D-CAG, and D-CTAG proved safer for elderly patients, especially in terms of hematologic toxicity. A prospective phase III randomized study is warranted to confirm these observations.Keywords: rhTPO, elderly, acute myeloid leukemia, CAG, decitabine
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- 2021
262. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, EuroSurg, Booth, Lesley, Runigamugabo, Emmy, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Tierney Weir, Carrie, Dajti, I, Allemand, C, Boccalatte, LA, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Ballester, AM, Tapper, KE, Zeff, N, Valenzuela, JI, Alurralde, C, Anastasio, J, Apas Perez de Nucci, A, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, García, JS, García, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Vasey, CE, Watson, EGR, Ip, C, Kealey, J, Lim, CSH, Sengupta, S, Ward, S, Wong, E, Gould, T, Gourlay, R, 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K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, J, Rosenkranz, K, Telma, K, Tocci, N, Wilkinson-Ryan, I, Bokenkamp, M, Brown, K, Fleming, D, Heron, C, Hill, C, Kay, H, Leede, E, McElhinney, K, Olson, KA, Osterberg, EC, Riley, C, Srikanth, P, Barbour, J, Blazer, D, DiLalla, GA, Fayanju, O, Hwang, ES, Kahmke, R, Kazaure, H, Lazarides, A, Lee, W, Lidsky, M, Menendez, C, Moris, D, Plichta, J, Pradhan, MC, Puscas, L, Rice, HE, Rocke, D, Rosenberger, L, Scheri, R, Smith, BD, Stang, MT, Tolnitch, L, Turnage, K, Visgauss, J, Walton, FS, Watts, T, Zani, S, Farma, J, Cardona, K, Russell, MC, Clark, J, Kwon, D, Goel, N, Kronenfeld, J, Bigelow, B, Etchill, E, Gabre-Kidan, A, Jenny, H, Kent, A, Ladd, MR, Long, C, Malapati, H, Margalit, A, Rapaport, S, Rose, J, Stevens, K, Tsai, L, Vervoort, D, Yesantharao, P, Dehal, A, Klaristenfeld, D, Huynh, K, Kaafarani, H, Naar, L, Qadan, M, Brown, L, Ganly, I, Mullinax, JE, Alpert, N, Gillezeau, C, Miles, DDS, Taioli, E, Cha, DE, Gleeson, E, Horn, C, Sarpel, U, Gusani, N, Hazelton, J, Maines, J, Oh, JS, Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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263. Abnormal B-cell development in TIMP-deficient bone marrow
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Weiss, Ashley, Saw, Sanjay, Aiken, Alison, Aliar, Kazeera, Shao, Yang W., Fang, Hui, Narala, Swami, Shetty, Ronak, Waterhouse, Paul D., and Khokha, Rama
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- 2021
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264. A review of pivotal energy management strategies for extended range electric vehicles
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Xiao, B., Ruan, J., Yang, W., Walker, P.D., and Zhang, N.
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- 2021
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265. Shape effects of gold nanoparticles in photothermal cancer therapy
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Yang, W., Xia, B., Wang, L., Ma, S., Liang, H., Wang, D., and Huang, J.
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- 2021
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266. Carbapenem-resistant Enterobacterales colonization and subsequent infection in a neonatal intensive care unit in Shanghai, China
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Yin, L., He, L., Miao, J., Yang, W., Wang, X., Ma, J., Wu, N., Cao, Y., and Wang, C.
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- 2021
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267. Soil Nutrients and Aggregate Composition of Four Soils with Contrasting Textures in a Long-Term Experiment
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Ding, S. J., Zhang, X. F., Yang, W. L., Xin, X. L., Zhu, A. N., and Huang, S. M.
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- 2021
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268. Ablation Stability of In Situ Al2O3 Layer in Aluminized AISI 4130 Steels under High-Temperature Plasma Flame Environments
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Yang, W. C., Lee, S., Chung, C.-H., Sakidja, R., and Park, J. S.
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- 2021
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269. In-situ Strain Field Measurement and Mechano-electro-chemical Analysis of Graphite Electrodes Via Fluorescence Digital Image Correlation
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Xie, H. M., Yang, W., Kang, Y. L., Zhang, Q., Han, B., and Qiu, W.
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- 2021
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270. Fisher information of a squeezed-state interferometer with a finite photon-number resolution
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Liu, P., Wang, P., Yang, W., Jin, G. R., and Sun, C. P.
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Quantum Physics ,Physics - Optics - Abstract
Squeezed-state interferometry plays an important role in quantum-enhanced optical phase estimation, as it allows the estimation precision to be improved up to the Heisenberg limit by using ideal photon-number-resolving detectors at the output ports. Here we show that for each individual $N$-photon component of the phase-matched coherent $\otimes$ squeezed vacuum input state, the classical Fisher information always saturates the quantum Fisher information. Moreover, the total Fisher information is the sum of the contributions from each individual $N$-photon components, where the largest $N$ is limited by the finite number resolution of available photon counters. Based on this observation, we provide an approximate analytical formula that quantifies the amount of lost information due to the finite photon number resolution, e.g., given the mean photon number $\bar{n}$ in the input state, over $96$ percent of the Heisenberg limit can be achieved with the number resolution larger than $5\bar{n}$., Comment: A new analytical result of the Fisher information (Eq.(18), or more generally, Eq.(B9)) has been derived to quantify how much the phase information is kept (or lost) due to finite number resolution of the photon-counting detectors
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- 2016
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271. Magnetic order and spin-orbit coupled Mott state in double perovskite (La$_{1-x}$Sr$_x$)$_2$CuIrO$_6$
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Zhu, W. K., Tung, J. -C., Tong, W., Ling, L., Starr, M., Wang, J. M., Yang, W. C., Losovyj, Y., Zhou, H. D., Wang, Y. Q., Lee, P. -H., Wang, Y. -K., Lu, Chi-Ken, and Zhang, S. X.
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science ,Physics - Computational Physics - Abstract
Double-perovskite oxides that contain both 3d and 5d transition metal elements have attracted growing interest as they provide a model system to study the interplay of strong electron interaction and large spin-orbit coupling (SOC). Here, we report on experimental and theoretical studies of the magnetic and electronic properties of double-perovskites (La$_{1-x}$Sr$_x$)$_2$CuIrO$_6$ ($x$ = 0.0, 0.1, 0.2, and 0.3). The undoped La$_2$CuIrO$_6$ undergoes a magnetic phase transition from paramagnetism to antiferromagnetism at T$_N$ $\sim$ 74 K and exhibits a weak ferromagnetic behavior below $T_C$ $\sim$ 52 K. Two-dimensional magnetism that was observed in many other Cu-based double-perovskites is absent in our samples, which may be due to the existence of weak Cu-Ir exchange interaction. First-principle density-functional theory (DFT) calculations show canted antiferromagnetic (AFM) order in both Cu$^{2+}$ and Ir$^{4+}$ sublattices, which gives rise to weak ferromagnetism. Electronic structure calculations suggest that La$_2$CuIrO$_6$ is an SOC-driven Mott insulator with an energy gap of $\sim$ 0.3 eV. Sr-doping decreases the magnetic ordering temperatures ($T_N$ and $T_C$) and suppresses the electrical resistivity. The high temperatures resistivity can be fitted using a variable-range-hopping model, consistent with the existence of disorders in these double-pervoskite compounds., Comment: Submitted; updated and added references in v2
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- 2016
272. Quantum-enhanced microscopy with binary-outcome photon counting
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Jin, G. R., Yang, W., and Sun, C. P.
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Quantum Physics - Abstract
Polarized light microscopy using path-entangled $N$-photon states (i.e., the N00N states) has been demonstrated to surpass the shot-noise limit at very low light illumination. However, the microscopy images suffer from divergence of phase sensitivity, which inevitably reduces the image quality. Here, we show that due to experimental imperfections, such a singularity also takes place in the microscopy that uses twin-Fock states of light for illumination. We propose two schemes to completely eliminate this singularity: (i) locking the phase shift sensed by the beams at the optimal working point, by using a spatially dependent offset phase; (ii) a combination of two binary-outcome photon counting measurements, one with a fixed offset phase and the other without any offset phase. Our observations remain valid for any kind of binary-outcome measurement and may open the way for quantum-enhanced microscopy with high $N$ photon states., Comment: 6 pages, 4 figures
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- 2016
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273. Observation of two distinct superconducting domes under pressure in tetragonal FeS
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Zhang, J., Liu, F. L., Ying, T. P., Li, N. N., Xu, Y., He, L. P., Hong, X. C., Yu, Y. J., Wang, M. X., Shen, J., Yang, W. G., and Li, S. Y.
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Condensed Matter - Superconductivity ,Condensed Matter - Materials Science ,Condensed Matter - Strongly Correlated Electrons - Abstract
As the simplest iron-based superconductor, FeSe forms a tetragonal structure with transition temperature Tc ~ 8 K. With assistance of pressure, or other techniques, Tc can be greatly enhanced, even to above liquid nitrogen temperature. The newly discovered superconducting tetragonal FeS (Tc ~ 4.5 K), a sulfide counterpart of FeSe, promotes us on its high pressure investigation. The transport and structure evolution of FeS with pressure have been studied. A rapid suppression of Tc and vanishing of superconductivity at 4.0 GPa are observed, followed by a second superconducting dome with a 30% enhancement in maximum Tc. An onsite tetragonal to hexagonal phase transition occurs around 7.0 GPa, followed by a broad pressure range of phase coexistence. The residual deformed tetragonal phase is considered as the source of second superconducting dome. The observation of two superconducting domes in iron-based superconductors poses great challenges for understanding their pairing mechanism., Comment: 20 pages, 5 figures
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- 2016
274. Cooling a Mechanical Resonator to Quantum Regime by heating it
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Ma, Yue, Yin, Zhang-qi, Huang, Pu, Yang, W. L., and Du, Jiangfeng
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Quantum Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
We consider a mechanical resonator made of diamond, which contains a nitrogen-vacancy center (NV center) locating at the end of the oscillator. A second order magnetic gradient is applied and inducing coupling between mechanical modes and the NV center. By applying proper external magnetic field, the energy difference between NV center electron spin levels can be tuned to match the energy difference between two mechanical modes $a$ and $b$. A laser is used for continuously initializing the NV center electron spin. The mode $a$ with lower frequency is driven by a thermal bath. We find that the temperature of the mode $b$ is significantly cooled when the heating bath temperature is increased. We discuss the conditions that quantum regime cooling requires, and confirm the results by numerical simulation. Finally we give the intuitive physical explanation on this unusual effect., Comment: 9 pages, 5 figures; added new figure in Fig. 2; Accepted for Phys. Rev. A
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- 2016
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275. Mechanism for quantum speedup in open quantum systems
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Liu, Hai-Bin, Yang, W. L., An, Jun-Hong, and Xu, Zhen-Yu
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Quantum Physics - Abstract
The quantum speed limit (QSL) time for open system characterizes the most efficient response of the system to the environmental influences. Previous results showed that the non-Markovianity governs the quantum speedup. Via studying the dynamics of a dissipative two-level system, we reveal that the non-Markovian effect is only the dynamical way of the quantum speedup, while the formation of the system-environment bound states is the essential reason for the quantum speedup. Our attribution of the quantum speedup to the energy-spectrum character can supply another vital path for experiments when the quantum speedup shows up without any dynamical calculations. The potential experimental observation of our quantum speedup mechanism in the circuit QED system is discussed. Our results may be of both theoretical and experimental interests in exploring the ultimate QSL in realistic environments, and may open new perspectives for devising active quantum speedup devices.
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- 2016
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276. Observation of a Three-Dimensional Quasi-Long-Range Electronic Supermodulation in YBa2Cu3O7-x/La0.7Ca0.3MnO3 Heterostructures
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He, Junfeng, Shafer, Padraic, Mion, Thomas R., Tra, Vu Thanh, He, Qing, Kong, J., Chuang, Y. -D., Yang, W. L., Graf, M. J., Lin, J. -Y., Chu, Y. -H., Arenholz, E., and He, Rui-Hua
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Condensed Matter - Strongly Correlated Electrons ,Condensed Matter - Materials Science ,Condensed Matter - Superconductivity - Abstract
Recent developments in high-temperature superconductivity highlight a generic tendency of the cuprates to develop competing electronic (charge) supermodulations. While coupled to the lattice and showing different characteristics in different materials, these supermodulations themselves are generally conceived to be quasi-two-dimensional, residing mainly in individual CuO2 planes, and poorly correlated along the c-axis. Here we observed with resonant elastic x-ray scattering a distinct type of electronic supermodulation in YBa2Cu3O7-x (YBCO) thin films grown epitaxially on La0.7Ca0.3MnO3 (LCMO). This supermodulation has a periodicity nearly commensurate with four lattice constants in-plane, eight out-of-plane, with long correlation lengths in three dimensions. It sets in far above the superconducting transition temperature and competes with superconductivity below this temperature for electronic states predominantly in the CuO2 plane. Our finding sheds new light on the nature of charge ordering in cuprates as well as a reported long-range proximity effect between superconductivity and ferromagnetism in YBCO/LCMO heterostructures., Comment: Nature Communications, in press
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- 2016
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277. Rechallenge of immune checkpoint inhibitors in a case with adverse events inducing myasthenia gravis
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Jun Li, Wei Wang, Wei Zhang, Yang W Shao, Lu Shen, Liang Chen, Wen Gao, Jiali Xu, Jiani C Yin, Renhua Guo, Qianghu Wang, Lingxiang Wu, Shidai Jin, Xinyin Liu, Qixing Gong, Chunxiao Sun, and Zidun Wang
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
The mechanism(s) of immune checkpoint inhibitor (ICI)-induced myasthenia gravis (MG), an immune-related adverse event (irAE) that is fatal and limits subsequent ICI use, remain unexplored. Here, through comparative genomic analysis, we identified a pathogenic p.S467C germline variant in SLC22A5 in a thymoma case with ICI-induced MG, which was found to be associated with fatty acid oxidation through its regulation on L-carnitine levels. Remarkably, ICI rechallenge with L-carnitine pretreatment led to durable response without MG-related symptoms. Thus, we provide the first clinical evidence of genetic test-directed irAE management, which integrates individualized ICI treatment into the evolving paradigm of cancer management.
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- 2022
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278. Realizing Topological Transition in a Non-Hermitian Quantum Walk with Circuit QED
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Huang, Yizhou, Yin, Zhang-qi, and Yang, W. L.
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Quantum Physics - Abstract
We extend the non-Hermitian one-dimensional quantum walk model [Phys. Rev. Lett. 102, 065703 (2009)] by taking the dephasing effect into account. We prove that the feature of topological transition does not change even when dephasing between the sites within units is present. The potential experimental observation of our theoretical results in the circuit QED system consisting of superconducting qubit coupled to a superconducting resonator mode is discussed and numerically simulated. The results clearly show a topological transition in quantum walk and display the robustness of such a system to the decay and dephasing of qubits. We also discuss how to extend this model to higher dimension in the circuit QED system., Comment: 8 pages, 9 figures; published version
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- 2016
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279. Phonon induced two-mode squeezing of nitrogen-vacancy center ensembles
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Xu, Qidong, Yang, W. L., and Yin, Zhang-qi
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Quantum Physics - Abstract
We propose a potentially practical scheme for realization of two-mode squeezed state with respect to two distant nitrogen-vacancy center ensembles coupled to two interconnected mechanical modes of diamond nanoresonators. By making use of the tunable phonon-spin interaction and the engineered phonon-phonon tunneling, both the desired excitation transfer process and the optimal two-mode squeezing between spin ensembles can be realized. We investigate the dynamics of the total system under infulences from the mechanical decay using both analytical and numerical methods, where the realistic conditions that leads to optimized squeezing between spin ensembles are analyzed., Comment: 7 pages, 5 pages
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- 2015
280. The Antitumor Activity of CAR-T-PD1 Cells Enhanced by HPV16mE7-Pulsed and SOCS1-Silenced DCs in Cervical Cancer Models
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Zheng J, Huang J, Ma W, Yang W, and Hu B
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pd1/pdl1 ,car-t ,dendritic cells ,suppressor of cytokine signaling 1 ,cervical cancer ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Jingwei Zheng,1,* Jingsong Huang,2,* Wei Ma,3 Wenqiang Yang,3 Bicheng Hu3 1Clinical Medical College of Jilin University, Changchun, 130012, People’s Republic of China; 2Department of Transfusion, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, 361101, People’s Republic of China; 3The Central Laboratory, Wuhan No.1 Hospital, the Hospital of Traditional Chinese and Western Medicine Affiliated to Hubei University of Chinese Medicine, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bicheng HuThe Central Laboratory, Wuhan No.1 Hospital, the Hospital of Traditional Chinese and Western Medicine Affiliated to Hubei University of Chinese Medicine, Wuhan, 430022, Hubei, People’s Republic of ChinaTel/Fax +86 27-85332367Email hubicheng211@sina.comBackground: Genetically T cells modified with cancer-specific chimeric antigen receptors (CARs) showed great promise in mediate tumor regression, especially in patients with advanced leukemia. However, the therapeutic effect against solid tumors is not as prominent as anticipated to exhibit potent antitumor efficacy. The underlying mechanism maybe attributed to the inhibitory co-stimulatory pathways such as (PD1/PDL1), which provide tumor cells an escape mechanism from immunosurveillance. Therefore, by exchanging the transmembrane and cytoplasmic tail of PD1 with positive costimulatory molecules, such as CD28 and 4– 1BB signaling domains (PD1-CD28-4-1BB, PD1-CAR), the T cell-negative co-stimulatory PD1/PDL1 signal pathway was thus converted into a positive one. This study aimed to investigate whether the genetically modified CAR-T-PD1 cells activated by SOCS1 silenced DCs have enhanced anti-neoplastic potential in vitro/in vivo.Methods: In order to enhance the antigenicity and reduce transformation activity, a modified HPV16 E7 (HPV16mE7) was employed to load on dendritic cells (DCs) with SOCS1 silenced to improve its antitumor efficiency and targeting ability against cervical cancer. The CAR-T-PD1 cells activated by the generated DCs were transfused into murine models bearing tumor of CaSki cells that expressing PDL1 and HPV16 E6/E7 for in vitro/in vivo antitumor activity assay.Results: The data showed that DC-activated CAR-T-PD1 cells significantly increased the secretion of IL-2, IFN-γ and TNF-α, whilst enhanced cytotoxic activity, suppressed tumor growth and prolong the survival time compared with the controls.Conclusion: These results indicated that the genetically engineered T cells activated by DCs had improved antitumor efficiency and targeting ability. Furthermore, it was suggested that it may have important implications for the improvement of T cell immunotherapy against cervical cancer.Keywords: PD1/PDL1, CAR-T, dendritic cells, suppressor of cytokine signaling 1, cervical cancer
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- 2021
281. Type C Behavior and Associated Factors in Patients with Breast Cancer During Postoperative Chemotherapy: A Cross-Sectional Study
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Shen XY, Lin Y, Miao R, Yao X, Sun H, and Yang W
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breast cancer ,type c behavior ,coping style ,social support ,social relational quality ,hope ,Psychology ,BF1-990 ,Industrial psychology ,HF5548.7-5548.85 - Abstract
Xiao-Ying Shen,1,* Yu-Ping Lin,2,* Run-Na Miao,3 Xue Yao,4 Hui Sun,5 Wei Yang5 1Second Clinical Medical College, Harbin Medical University, Harbin, People’s Republic of China; 2School of Nursing, Fudan University, Shanghai, People’s Republic of China; 3Department of Nursing, Health Science Centre, Xi’an Jiaotong University, Xi’an, People’s Republic of China; 4School of Nursing, Shandong University, Shandong, People’s Republic of China; 5Heilongjiang Second Hospital, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiao-Ying ShenSecond Clinical Medical College, Harbin Medical University, Harbin, 150086, People’s Republic of ChinaTel +86 13351883728Email 337372672@qq.comBackground: Type C behavior is a cancer-prone behavior that can affect the occurrence and development of cancer. This study aimed to investigate the prevalence of type C behavior in patients with breast cancer during postoperative chemotherapy and determine its associated factors.Methods: This study enrolled 161 patients with breast cancer who received postoperative chemotherapy. Type C personality behavior pattern questionnaire was used to assess type C behavior patterns. The following instruments were employed: medical coping modes questionnaire, social support scale, social relational quality scale, Herth hope index. logistic regression was used to identify the factors affecting type C behavior.Results: The incidence of type C behavior was 28%. Participants aged 45– 59 years (OR = 3.62, 95% CI = 1.04– 12.56, P = 0.043), and who adopted a resignation coping style (OR = 1.25, 95% CI = 1.03– 1.50, P = 0.021), were more likely to develop type C behavior. Type C behavior was less common in patients with employment (OR = 0.38, 95% CI = 0.15– 0.97, P = 0.043), with a high level of social support (OR = 0.89, 95% CI= 0.80– 0.98, P = 0.023), and more hope (OR = 0.83, 95% CI = 0.71– 0.98, P = 0.079).Conclusion: In this study, 28% patients with breast cancer during postoperative chemotherapy exhibited type C behavior. Associated factors with type C behavior were identified, which could guide health care professionals to reduce the prevalence of type C behavior through guiding patients to adopt positive coping styles and improving their level of social support and hope, especially in those aged 45 to 59 years or in those without employment.Keywords: breast cancer, type C behavior, coping style, social support, social relational quality, hope
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- 2021
282. Predictive Models for HCC Prognosis, Recurrence Risk, and Immune Infiltration Based on Two Exosomal Genes: MYL6B and THOC2
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Zhu J, Tang B, Gao Y, Xu S, Tu J, Wang Y, Yang W, Fang S, Weng Q, Zhao Z, Xu M, Yang Y, Chen M, Lu C, and Ji J
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exosome ,hepatocellular carcinoma (hcc) ,immune checkpoint ,prognosis ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Jinyu Zhu,1,2,* Bufu Tang,1,3,* Yang Gao,1,4 Suqin Xu,5 Jianfei Tu,1,4 Yajie Wang,4 Weibin Yang,1,4 Shiji Fang,4 Qiaoyou Weng,4 Zhongwei Zhao,1,4 Min Xu,1,4 Yang Yang,1,4 Minjiang Chen,1,4 Chenying Lu,1,4 Jiansong Ji1,4 1Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui, 323000, People’s Republic of China; 2Department of Radiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, People’s Republic of China; 3Department of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, People’s Republic of China; 4Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, 323000, People’s Republic of China; 5Clinical Laboratory, Fuyuan Hospital of Yiwu, Jinhua, 321000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiansong Ji; Chenying Lu Email jijiansong@zju.edu.cn; luchenying@zju.edu.cnIntroduction: Hepatocellular carcinoma (HCC) is a heterogeneous molecular disease with complex molecular pathogenesis that influences the efficacy of therapies. Exosomes play a crucial role in tumorigenesis and poor disease outcomes in HCC.Objective: The aim of this study was to identify the optimal gene set derived from exosomes in HCC with substantial predictive value to construct models for determining prognosis, recurrence risk and diagnosis and to identify candidates suitable for immunotherapy and chemotherapy, thereby providing new ideas for the individualized treatment of patients and for improving prognosis.Methods: Weighted correlation network analysis (WGCNA) and univariate and multivariate Cox PH regression analyses were applied to identify exosome-related signatures in the TCGA and exoRbase databases associated with clinical relevance, immunogenic features and tumor progression in HCC. Cell experiments were performed to further confirm the oncogenic effect of MYL6B and THOC2.Results: The models for prognosis and recurrence risk prediction were built based on two exosomal genes (MYL6B and THOC2) and were confirmed to be independent predictive factors with superior predictive performance. Patients with high prognostic risk had poorer prognosis than patients with low prognostic risk in all HCC datasets, namely, the TCGA cohort (HR=2.5, P< 0.001), the ICGC cohort (HR=3.15, P< 0.001) and the GSE14520 cohort (HR=1.85, P=0.004). A higher recurrence probability was found in HCC patients with high recurrence risk than in HCC patients with low recurrence risk in the TCGA cohort (HR=2.44, P< 0.001) and the GSE14520 cohort (HR=1.54, P=0.025). High prognostic risk patients had higher expression of immune checkpoint genes, such as PD1, B7H3, B7H5, CTLA4 and TIM3 (P< 0.05). Diagnostic models based on the same two genes were able to accurately distinguish HCC patients from normal individuals and HCC from dysplastic nodules.Conclusion: Our findings lay the foundation for identifying molecular markers to increase the early detection rate of HCC, improve disease outcomes, and determine more effective individualized treatment options for patients.Keywords: exosome, hepatocellular carcinoma, HCC, immune checkpoint, prognosis
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- 2021
283. Endoglin-Aptamer-Functionalized Liposome-Equipped PD-1-Silenced T Cells Enhance Antitumoral Immunotherapeutic Effects
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Xie S, Hou X, Yang W, Shi W, Yang X, Duan S, Mo F, Liu A, Wang W, and Lu X
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nanoliposome ,pd-1 ,crispr/cas9 ,endoglin ,aptamer ,antitumor immunotherapy ,Medicine (General) ,R5-920 - Abstract
Shenxia Xie,1,2,* Xiaoqiong Hou,1,3,* Wei Yang,1,3,* Wei Shi,1,3 Xiaomei Yang,1,3 Siliang Duan,3 Fengzhen Mo,3 Aiqun Liu,3 Wu Wang,1,4 Xiaoling Lu1,3,5 1School of Preclinical Medicine, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 3International Nanobody Research Center of Guangxi, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 4Laboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, Hainan, 571101, People’s Republic of China; 5College of Stomatology, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaoling LuCollege of Stomatology, Guangxi Medical University, Nanning, Guangxi, 530021, People’s Republic of ChinaEmail luxiaoling@gxmu.edu.cnWu WangLaboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, Hainan, 571101, People’s Republic of ChinaEmail lxd8860@163.comBackground: The broader application of adoptive cell therapy (ACT) in cancer immunotherapies (particularly for solid tumors) has always been limited by the immunosuppressive tumor microenvironment (TME) and the insufficient targetability of effector T cells, resulting in unsatisfied therapeutic outcome. Here, we designed a new strategy by using aptamer-based immunoliposomes to modify PD-1-silencing T cells, which were activated by dendritic cell (DC)/tumor fusion cells (FCs) to improve the antitumor potency of cytotoxic T lymphocytes (CTLs/CD8+ T cells).Methods: PD-1 gene was knocked out from CD8+ T cells using CRISPR/Cas9 system to liberate T cell activity from immunosuppression. The PD-1− T cells were stimulated with DC/tumor FCs, followed by further functional modification of tumor-specific nanoliposomes (hEnd-Apt/CD3-Lipo) to generate FC/PD-1− CTLs. The activation and proliferation and specificity of the modified FC/PD-1− CTLs were measured. The antitumor activity of these CTLs against HepG2-tumors was evaluated in xenograft NOD/SCID mice, and the antitumor mechanism was investigated based on tissue immunohistochemistry and serum ELISA.Results: Our results indicated that the modification of hEnd-Apt/CD3-Lipo nanocomposites on the FC/PD-1− CTLs had a more substantial synergetic effect in inhibiting tumor growth and prolonging animal survival, rather than other control liposomes. Furthermore, the hEnd-Apt/CD3-Lipo-modified FC/PD-1− CTLs showed a stronger antitumor outcome in the tumor-bearing mouse model, through the mechanisms of suppressing tumor cell proliferation, promoting tumor apoptosis, reducing angiogenesis but increasing the infiltration of the FC/PD-1− CTLs in the tumor tissue, as well as upregulating the systemic levels of IFN-γ, IL-2, TNF-α and IL-6 cytokines, by comparison of the control settings.Conclusion: In sum, our investigation suggests an enhancement of antitumor effect by the surface modification of endoglin-targeting nanoliposomes upon DC/tumor FC-activated PD-1− CTLs, therefore, provides a new tumoral endoglin-targeted approach as a promising strategy to reduce immunosuppression of tumor microenvironment and improve the immunotherapeutic outcome of anticancer ACT.Keywords: nanoliposome, PD-1, CRISPR/Cas9, endoglin, aptamer, antitumor immunotherapy
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- 2021
284. Prognostic Values of Different Clinicopathological Factors and Predictive Models for Penile Carcinoma
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Shao Y, Lia T, Wang Y, Wu K, Hu X, Liu Y, Feng S, Ren S, Yang Z, Xiong S, Yang W, Wei Q, Zeng H, and Li X
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penile cancer ,tnm stage ,survival ,nomogram ,external validation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Yanxiang Shao,1,* Thongher Lia,1,* Yaohui Wang,1,* Kan Wu,1 Xu Hu,1 Yang Liu,1 Shuyang Feng,1 Shangqing Ren,1,2 Zhen Yang,1,3 Sanchao Xiong,1 Weixiao Yang,1 Qiang Wei,1 Hao Zeng,1 Xiang Li1 1Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Robotic Minimally Invasive Surgery Center, Sichuan Academy of Medical Sciences & Sichuan Provincial People’s Hospital, Chengdu, 610072, People’s Republic of China; 3Department of Urology, Chengdu Second People’s Hospital, Chengdu, 610021, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiang LiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, 37 GuoXueXiang, Chengdu, 610041, People’s Republic of ChinaEmail xiangli87@hotmail.comObjective: To evaluate the prognostic factors of penile cancer and the utility of prognostic models.Methods: We analyzed postoperatively collected data of 311 patients diagnosed with penile cancer. Survival analysis (Kaplan–Meier and cox regression methods) was performed on this cohort. The c-index was used to determine the predictive accuracies of potential prognostic factors. The accuracies of four prognostic models were also evaluated, which were AJCC prognostic stage group for three recent editions, and four nomograms constructed by the Surveillance, Epidemiology, and End Results program (SEER). Two novel nomograms using our data were created and AUC of 2-year survival were determined to compare existing and newly established models.Results: Tumor site, T and N stages, nuclear grade and lymph vascular invasion (LVI) significantly influenced prognosis. The 8th T and N stages had better c-indexes than former editions, while no improvement was seen in the 8thAJCC stage group. 6th AJCC+grade nomogram had a higher c-index than other three nomograms (SEER+grade, 6th TNM+grade, and 6th T1-3N0-3+grade nomograms; c-index: 0.831 vs 0.738, 0.792 and 0.781). New nomogram 1 included the 8th T and N stages, tumor site, nuclear grade, and LVI, with a c-index of 0.870. Novel nomogram 2 replaced the T and N stages with the AJCC stage group, which had a lower c-index of 0.855. The order of prediction accuracy of 2-year survival in the old and new models is consistent with the c-index results.Conclusion: Tumor site, stages, grade, and LVI play important roles in predicting survival of penile cancer. The 8th stages have better predictive accuracy than former editions. We proposed two models with better predictive accuracy than former models; specifically, nomogram 1 may be a more precise and convenient tool for predicting penile cancer outcomes.Keywords: penile cancer, TNM stage, survival, nomogram, external validation
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- 2021
285. Effects of Atmospheric Fine Particulate Matter and Its Carrier Microbes on Pulmonary Microecology in Patients with COPD
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Che C, Sun X, Wu Y, Ma L, Hu Y, Yang W, Qi H, and Zhou Y
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copd ,atmospheric fine particulate matter ,bronchoalveolar lavage fluid ,microbe ,pulmonary microecology ,Diseases of the respiratory system ,RC705-779 - Abstract
Chunli Che, 1 Xiazhong Sun, 2 Yuhan Wu, 1 Lixin Ma, 2 Yueying Hu, 3 Weiyan Yang, 3 Hong Qi, 2 Yumin Zhou 4 1Harbin Medical University, Harbin, 150001, Heilongjiang, People’s Republic of China; 2State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, People’s Republic of China; 3Department of Respiratory Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, People’s Republic of China; 4State Key Laboratory of Respiratory Disease, National Center for Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangdong Sheng, People’s Republic of ChinaCorrespondence: Hong Qi; Yumin Zhou Email hongqi@hit.edu.cn; zhouyumin410@126.comObjective: The aim of this paper was to analyse the influence of atmospheric fine particulate matter (AFPM) and atmospheric microorganisms on the pulmonary microecology of chronic obstructive pulmonary disease (COPD) patients in northeast China.Methods: Collected bronchoalveolar lavage fluid (BALF) of COPD patients in the high-risk period (group A) and low-risk period (group B) of AFPM inhalation and samples of AFPM in the same time range (group C) were collected. DNA sample sequencing, the bacterial abundance, and diversity bioinformatics of BALFs were performed by methods of Illumina MiSeq™ platform and Mothur and Uclust.Results: A total of 58 samples were sequenced, including 22 samples from group A, 26 samples from group B and 10 samples from group C. A total of 2,005,790 bacterial sequences and 34,256 bacterial numbers were detected. Group B had the highest bacterial diversity of the three groups. Group B also had the highest bacterial abundance index value. There were differences in the classification of bacterial colonies for the three groups at the genus level. The types of bacteria in group C were more numerous than other groups, and group B was higher than group A, which indicates that there were more bacteria in BALF during the high-risk period of AFPM inhalation. The detection rates of Streptococcus, Mycoplasma, Roche, Pushia, Chlamydia trachomatis and Brucella for group C were significantly higher than group A. The COG and KEGG databases’ difference analysis results for the bacterial gene function abundance of group A and group B were 40.7% in group A and 38.9% in group B (R=0.098, P=0.006). The human disease abundance in group A and group B was 1.16% and 1.12%, respectively (P> 0.05).Conclusion: The increase in the concentration of AFPM can increase the diversity and abundance of bacteria in the BALF of stable COPD patients.Clinical Trial Registration Number: 2020XS04-02.Keywords: COPD, atmospheric fine particulate matter, bronchoalveolar lavage fluid, microbe, pulmonary microecology
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- 2021
286. The Maturation of Tumor Suppressor miR-497 in Hepatocellular Carcinoma is Inhibited by Oncogenic circRNA SCARB1
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Zhu S, Cao S, Yang W, Che J, Li D, Pei R, and Ding Y
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hepatocellular carcinoma ,circrna scarb1 ,mir-497 ,precursor ,maturation ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Shuo Zhu,1 Shengya Cao,2 Weibin Yang,1 Jinhui Che,1 Deqiang Li,1 Ruifeng Pei,1 Yiren Ding1 1Department of Hepatobiliary Surgery, Xuzhou Cancer Hospital, Xuzhou City, Jiangsu Province, 221000, People’s Republic of China; 2Department of Clinical Laboratory, Xuzhou Cancer Hospital, Xuzhou City, Jiangsu Province, 221000, People’s Republic of ChinaCorrespondence: Yiren DingDepartment of Hepatobiliary Surgery, Xuzhou Cancer Hospital, No. 131 Huancheng Road, Gulou District, Xuzhou City, Jiangsu Province, 221000, People’s Republic of ChinaEmail yirendingxuzhou@163.comIntroduction: Circular RNA (CircRNA) SCARB1 plays an oncogenic role in renal cell carcinoma, while its role in other cancers is unclear. The aim of this study was to explore the role of circRNA SCARB1 in hepatocellular carcinoma (HCC).Methods: The expression of circRNA SCARB1, mature miR-497 and miR-497 precursor in HCC and paired non-tumor tissues from 64 HCC patients were analyzed by RT-qPCR. CircRNA SCARB1 was overexpressed in HCC cells, followed by the measurement of the expression levels of both mature miR-497 and miR-497 precursor to evaluate the effects of overexpression of circRNA SCARB1 on the maturation of miR-497. The effects of circRNA SCARB1 and miR-497 on the proliferation and migration of HCC cells were assessed by CCK-8 assay and Transwell assay, respectively.Results: We found that circRNA SCARB1 was upregulated in HCC. In addition, mature miR-497 and miR-497 were downregulated in HCC. Correlation analysis showed that circRNA SCARB1 was inversely correlated with mature miR-497 but not miR-497 precursor. Consistently, in HCC cells, downregulated mature miR-497, but not miR-497 precursor, was observed in HCC cells transfected with circRNA SCARB1 expression vector. Analysis of cellular behaviors showed that overexpression of circRNA SCARB1 increased the proliferation and migration of HCC cells, while overexpression of miR-497 decreased cell proliferation and migration. Moreover, overexpression of miR-497 reduced the effects of overexpression of circRNA SCARB1.Discussion: Therefore, circRNA SCARB1 is upregulated in HCC and promotes HCC cell proliferation and migration by suppressing the maturation of miR-497.Keywords: hepatocellular carcinoma, circRNA SCARB1, miR-497, precursor, maturation
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- 2021
287. Density functional theory screening of some fundamental physical properties of Cs2InSbCl6 and Cs2InBiCl6 double perovskites
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Alnujaim, S., Bouhemadou, A., Chegaar, M., Guechi, A., Bin-Omran, S., Khenata, R., Al-Douri, Y., Yang, W., and Lu, H.
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- 2022
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288. A novel red-emitting Sr7Sb2O12:Eu3+, M+ (M = Li, Na, K) phosphor for warm white LED: synthesis, optical properties, and LED fabrication
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Yang, W. B., Xiong, F. B., Yang, Y., Lin, H. F., Meng, X. G., Ma, E., and Zhu, W. Z.
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- 2022
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289. Large-area uniform few-layer PtS2: Synthesis, structure and physical properties
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Lu, J., Zhang, X., Su, G., Yang, W., Han, K., Yu, X., Wan, Y., Wang, X., and Yang, P.
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- 2021
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290. Adverse childhood experiences and co-occurring psychological distress and substance abuse among juvenile offenders: the role of protective factors
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Lensch, T., Clements-Nolle, K., Oman, R.F., Evans, W.P., Lu, M., and Yang, W.
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- 2021
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291. Leakage Rates of Refrigerants CFC-12, HCFC-22, and HFC-134a from Operating Mobile Air Conditioning Systems in Guangzhou, China: Tests inside a Busy Urban Tunnel under Hot and Humid Weather Conditions
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Zhang, Y, Yang, W, Huang, Z, Liu, D, Simpson, I, Blake, DR, George, C, and Wang, X
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Environmental Science and Management ,Environmental Engineering ,Environmental Biotechnology - Abstract
Determining the leakage rates of halogenated refrigerants from operating mobile air conditioning systems (MACs) is a challenging task. Here, we take advantage of a heavily trafficked tunnel with a traffic flow of over 40,000 motor vehicles per day in south China. We carried out measurements in 2014 on hot and humid days, and therefore, it is reasonable to assume that essentially all of the MAC units would be turned on to ensure the thermo-comfort of the occupants. Thus, we obtained the leakage rates of the three most important refrigerants from the operating MACs aboard the on-road vehicles. The emission factors (EFs) of HFC-134a, HCFC-22, and CFC-12 from the on-road operating MACs are 1.27 ± 0.11, 0.47 ± 0.04, and 0.17 ± 0.04 mg km-1 veh-1, respectively. Normalized by the percentages of vehicles using different refrigerants in their MACs, the emission rates of HFC-134a, HCFC-22, and CFC-12 are 52.2, 329, and 59.5 mg h-1 veh-1, respectively. This emission rate of HFC-134a is approximately 10 times higher than those previously reported in Europe for stationary conditions and a whole-lifetime average of fugitive losses. The unusually high leakage rates suggest that improving the leak tightness of MACs in China would help to greatly lower their emissions. The global warming potentials associated with refrigerant leakage is equal to 1.4% of the CO2 directly emitted due to fuel consumptions.
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- 2017
292. Na-Ion Intercalation and Charge Storage Mechanism in 2D Vanadium Carbide
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Bak, SM, Qiao, R, Yang, W, Lee, S, Yu, X, Anasori, B, Lee, H, Gogotsi, Y, and Yang, XQ
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charge storage ,MXene ,sodium-ion batteries ,vanadium carbide ,X-ray absorption spectroscopy ,Macromolecular and Materials Chemistry ,Materials Engineering ,Interdisciplinary Engineering - Abstract
2D vanadium carbide MXene containing surface functional groups (denoted as V2CTx, where Tx are surface functional groups) is synthesized and studied as anode material for Na-ion batteries. V2CTx anode exhibits reversible charge storage with good cycling stability and high rate capability through electrochemical test. The charge storage mechanism of V2CTx material during Na+ intercalation/deintercalation and the redox reaction of vanadium are studied using a combination of synchrotron based X-ray diffraction, hard X-ray absorption near edge spectroscopy (XANES), and soft X-ray absorption spectroscopy (sXAS). Experimental evidence of a major contribution of redox reaction of vanadium to the charge storage and the reversible capacity of V2CTx during sodiation/desodiation process are provided through V K-edge XANES and V L2,3-edge sXAS results. A correlation between the CO32− content and the Na+ intercalation/deintercalation states in the V2CTx electrode observed from C and O K-edge in sXAS results implies that some additional charge storage reactions may take place between the Na+-intercalated V2CTx and the carbonate-based nonaqueous electrolyte. The results of this study provide valuable information for the further studies on V2CTx as anode material for Na-ion batteries and capacitors.
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- 2017
293. Zn-Se-Cd-S Interlayer Formation at the CdS/Cu2ZnSnSe4 Thin-Film Solar Cell Interface
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Bär, M, Repins, I, Weinhardt, L, Alsmeier, JH, Pookpanratana, S, Blum, M, Yang, W, Heske, C, Wilks, RG, and Noufi, R
- Abstract
The chemical structure of the CdS/Cu2ZnSnSe4 (CZTSe) interface was studied by a combination of electron and X-ray spectroscopies with varying surface sensitivity. We find the CdS chemical bath deposition causes a "redistribution" of elements in the proximity of the CdS/CZTSe interface. In detail, our data suggest that Zn and Se from the Zn-terminated CZTSe absorber and Cd and S from the buffer layer form a Zn-Se-Cd-S interlayer. We find direct indications for the presence of Cd-S, Cd-Se, and Cd-Se-Zn bonds at the buffer/absorber interface. Thus, we propose the formation of a mixed Cd(S,Se)-(Cd,Zn)Se interlayer. We suggest the underlying chemical mechanism is an ion exchange mediated by the amine complexes present in the chemical bath.
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- 2017
294. Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
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Karol, SE, Larsen, E, Cheng, C, Cao, X, Yang, W, Ramsey, LB, Fernandez, CA, McCorkle, JR, Paugh, SW, Autry, RJ, Lopez-Lopez, E, Diouf, B, Jeha, S, Pui, C-H, Raetz, EA, Winick, NJ, Carroll, WL, Hunger, SP, Loh, ML, Devidas, M, Evans, WE, Yang, JJ, and Relling, MV
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Patient Safety ,Cancer ,Pediatric Cancer ,Pediatric ,Childhood Leukemia ,Clinical Research ,Genetics ,Hematology ,Rare Diseases ,Evaluation of treatments and therapeutic interventions ,6.1 Pharmaceuticals ,Adult ,Biomarkers ,Tumor ,Female ,Follow-Up Studies ,Genetic Predisposition to Disease ,Genotype ,Humans ,Male ,Neoplasm Recurrence ,Local ,Neoplasm Staging ,Polymorphism ,Single Nucleotide ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Prognosis ,Risk Factors ,Clinical Sciences ,Oncology and Carcinogenesis ,Immunology - Abstract
The causes of individual relapses in children with acute lymphoblastic leukemia (ALL) remain incompletely understood. We evaluated the contribution of germline genetic factors to relapse in 2225 children treated on Children's Oncology Group trial AALL0232. We identified 302 germline single-nucleotide polymorphisms (SNPs) associated with relapse after adjusting for treatment and ancestry and 715 additional SNPs associated with relapse in an ancestry-specific manner. We tested for replication of these relapse-associated SNPs in external data sets of antileukemic drug pharmacokinetics and pharmacodynamics and an independent clinical cohort. 224 SNPs were associated with rapid drug clearance or drug resistance, and 32 were replicated in the independent cohort. The adverse risk associated with black and Hispanic ancestries was attenuated by addition of the 4 SNPs most strongly associated with relapse in these populations (for blacks: model without SNPs hazard ratio (HR)=2.32, P=2.27 × 10-4, model with SNPs HR=1.07, P=0.79; for Hispanics: model without SNPs HR=1.7, P=8.23 × 10-5, model with SNPs HR=1.31, P=0.065). Relapse SNPs associated with asparaginase resistance or allergy were overrepresented among SNPs associated with relapse in the more asparaginase intensive treatment arm (20/54 in Capizzi-methorexate arm vs 8/54 in high-dose methotrexate arm, P=0.015). Inherited genetic variation contributes to race-specific and treatment-specific relapse risk.
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- 2017
295. Effect of excess lithium in LiMn2O4 and Li1.15Mn1.85O4 electrodes revealed by quantitative analysis of soft X-ray absorption spectroscopy
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Zhuo, Z, Olalde-Velasco, P, Chin, T, Battaglia, V, Harris, SJ, Pan, F, and Yang, W
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Physical Sciences ,Engineering ,Technology ,Applied Physics - Abstract
We performed a comparative study of the soft x-ray absorption spectroscopy of the LiMn2O4 and Li1.15Mn1.85O4 electrode materials with a quantitative analysis of Mn oxidation states. The revealed redox evolution of Mn upon electrochemical cycling clarifies the effect of excess Li in the materials, which naturally explains the different electrochemical performance. The spectral analysis perfectly agrees with different initial cycling capacities of the two materials. The results show unambiguously that Mn3+ starts to dominate the electrode surface after only one cycle. More importantly, the data show that, while LiMn2O4 electrodes follow the nominal Mn redox evolution, the formation of Mn3+ on the electrode surface is largely retarded for Li1.15Mn1.85O4 during most of the electrochemical processes. Such a different surface Mn redox behavior leads to differences in the detrimental effects of Mn2+ formation on the surface, which is observed directly after only two cycles. Our results provide strong evidence that a key effect of the (bulk) excess Li doping is actually due to processes on the electrode surfaces.
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- 2017
296. Transition-metal redox evolution in LiNi0.5Mn0.3Co0.2O2 electrodes at high potentials
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Qiao, R, Liu, J, Kourtakis, K, Roelofs, MG, Peterson, DL, Duff, JP, Deibler, DT, Wray, LA, and Yang, W
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Lithium-ion batteries ,LiNi0.5Mn0.3Co0.2O2 ,High voltage ,Soft x-ray spectroscopy ,Energy ,Chemical Sciences ,Engineering - Abstract
The mixed transition-metal layered compound, LiNi0.5Mn0.3Co0.2O2 (NMC532), is a promising high-energy cathode material. However, the required high-voltage (>4.3 V) cycling is accompanied by a rapid capacity fade associated with a complex redox mechanism that has not been clarified. Here we report soft x-ray absorption spectroscopy of NMC532 electrodes, both pristine and those charged to 4.2, 4.35, or 4.5 V in graphite/NMC532 cells. A quantitative sXAS analysis shows that about 20% of the nickel exists as Ni4+ in the as-synthesized NMC532. The Ni redox reaction contributes only to the experimental capacity obtained below 4.2 V, while Co redox reactions take place throughout the entire electrochemical cycling up to 4.5 V. In contrast to the changing ratio of the well-defined Ni2+, Ni3+ and Ni4+ ions, Co always displays ill-defined intermediate valence states in the charged NMC532 electrodes. This indicates an itinerant electron system in NMC electrodes related to the improved rate performance through Co doping. Additionally, about 20% of Ni2+ is found on the electrode surface at the high potential, which suggests that the electrode surface has either gone through surface reconstruction or reacted with the electrolyte at high voltage.
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- 2017
297. Springtime extrememoisture transport into the Arctic and its impact on sea ice concentration
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Yang, W and Magnusdottir, G
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Meteorology & Atmospheric Sciences - Abstract
Recent studies suggest that springtime moisture transport into the Arctic can initiate sea ice melt that extends to a large area in the following summer and fall, which can help explain Arctic sea ice interannual variability. Yet the impact from an individual moisture transport event, especially the extreme ones, is unclear on synoptic to intraseasonal time scales and this is the focus of the current study. Springtime extreme moisture transport into the Arctic from a daily data set is found to be dominant over Atlantic longitudes. Lag composite analysis shows that these extreme events are accompanied by a substantial sea ice concentration reduction over the Greenland-Barents-Kara Seas that lasts around a week. Surface air temperature also becomes anomalously high over these seas and cold to the west of Greenland as well as over the interior Eurasian continent. The blocking weather regime over the North Atlantic is mainly responsible for the extreme moisture transport, occupying more than 60% of the total extreme days, while the negative North Atlantic Oscillation regime is hardly observed at all during the extreme transport days. These extreme moisture transport events appear to be preceded by eastward propagating large-scale tropical convective forcing by as long as 2 weeks but with great uncertainty due to lack of statistical significance.
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- 2017
298. Additive manufacturing of a near-eutectic Mo–Si–B alloy: Processing and resulting properties
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Fichtner, D., Schmelzer, J., Yang, W., Heinze, C., and Krüger, M.
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- 2021
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299. An ITO-Free Kesterite Solar Cell
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Ji, Y, Chen, W, Yan, D, Bullock, J, Xu, Y, Su, Z, Yang, W, Laird, JS, Zheng, T, Wu, N, Zha, W, Luo, Q, Ma, C-Q, Smith, TA, Liu, F, Mulvaney, P, Ji, Y, Chen, W, Yan, D, Bullock, J, Xu, Y, Su, Z, Yang, W, Laird, JS, Zheng, T, Wu, N, Zha, W, Luo, Q, Ma, C-Q, Smith, TA, Liu, F, and Mulvaney, P
- Abstract
Photovoltaic thin film solar cells based on kesterite Cu2 ZnSn(S, Se)4 (CZTSSe) have reached 13.8% sunlight-to-electricity conversion efficiency. However, this efficiency is still far from the Shockley-Queisser radiative limit and is hindered by the significant deficit in open circuit voltage (VOC ). The presence of high-density interface states between the absorber layer and buffer or window layer leads to the recombination of photogenerated carriers, thereby reducing effective carrier collection. To tackle this issue, a new window structure ZnO/AgNW/ZnO/AgNW (ZAZA) comprising layers of ZnO and silver nanowires (AgNWs) is proposed. This structure offers a simple and low-damage processing method, resulting in improved optoelectronic properties and junction quality. The ZAZA-based devices exhibit enhanced VOC due to the higher built-in voltage (Vbi ) and reduced interface recombination compared to the usual indium tin oxide (ITO) based structures. Additionally, improved carrier collection is demonstrated as a result of the shortened collection paths and the more uniform carrier lifetime distribution. These advances enable the fabrication of the first ITO-free CZTSSe solar cells with over 10% efficiency without an anti-reflective coating.
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- 2024
300. Volatile-char interactions during co-pyrolysis of sewage sludge and poplar wood
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Zhu, Y., Liu, D., Tan, Z., Liu, H., Kan, T., Zhang, Wennan, Li, H., Li, Y., Yang, W., Yang, H., Zhu, Y., Liu, D., Tan, Z., Liu, H., Kan, T., Zhang, Wennan, Li, H., Li, Y., Yang, W., and Yang, H.
- Abstract
Pyrolysis is a thermo-chemical conversion method for harmless and resource utilization of sewage sludge, which gives carbon-containing products with high added value and benefits for GHG reduction towards “carbon peaking and carbon neutrality” goals. In this work, co-pyrolysis of sewage sludge and poplar wood was studied to investigate the effects of the wood blend ratio and the volatile-char interactions on the pyrolysis product characteristics. It was found that the synergistic effect during co-pyrolysis could enhance the production of aromatic hydrocarbons but inhibit the formation of nitrogen-containing and phenolic compounds. Meanwhile, the aromaticity of the char increased with increasing the wood blend ratio, resulting in an enhanced quality of the char. The volatile-char interactions could facilitate the cracking of large molecules in volatiles into small-molecule gases, leading to an increase in the gas yield of 0.6–14.6 %, and especially the H2 yield of 16.2–53.8 %, as compared to the case without interaction in the experiment. The char yields hold fairly constant but the physicochemical structure of the char changed significantly with the interactions. Specifically, the O-containing functional groups on the char surface decreased significantly with increasing aromaticity and stability. More importantly, the total phosphorus content of char was increased by 11.3–33.6 %, as compared to the case without interaction, with the enhanced conversion of non-hydroxyapatite phosphorus to hydroxyapatite phosphorus. The interaction can increase bio-availability of the phosphorus and make biochar to be a better organic fertilizer in application.
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- 2024
- Full Text
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