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260. Membrane sweeping in patients planning a trial of labor after cesarean: a systematic review and meta-analysis of randomized controlled trials

Author

Johanna Quist-Nelson, Odessa P. Hamidi, Vincenzo Berghella, and Serena Xodo

Subjects
medicine.medical_specialty, ComputingMethodologies_SIMULATIONANDMODELING, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Pregnancy, Medicine, Humans, natural sciences, In patient, 030212 general & internal medicine, Labor, Induced, Cesarean delivery, Intensive care medicine, reproductive and urinary physiology, Randomized Controlled Trials as Topic, 030219 obstetrics & reproductive medicine, Labor, Obstetric, ComputingMilieux_THECOMPUTINGPROFESSION, business.industry, Cesarean Section, musculoskeletal, neural, and ocular physiology, Obstetrics and Gynecology, Delivery, Obstetric, Trial of Labor, ComputingMilieux_GENERAL, ComputingMethodologies_PATTERNRECOGNITION, Meta-analysis, Pediatrics, Perinatology and Child Health, Female, sense organs, business, psychological phenomena and processes
Abstract

Background: Membrane sweeping has been shown to reduce time to the onset of labor in women at term but the effects of membrane sweeping in women with a prior cesarean delivery are largely unknown. Objective: To determine the effects of membrane sweeping on promoting labor in patients undergoing a trial of labor after cesarean. Study design: Searches were performed in Medline, Ovid, Scopus, ClinicalTrials.gov, and the Cochrane Central Register of Controlled Trials using a combination of keywords related to “membrane sweeping,” “membrane stripping,” “vaginal birth after cesarean,” and “trial of labor after cesarean” from inception of databases until April 2018. Study eligibility criteria: We included all randomized controlled trials (RCTs) of singleton or twin gestations at 36 weeks or greater that evaluated prophylactic or prelabor membrane sweeping in patients undergoing a trial of labor after cesarean. Exclusion criteria were trials that did not include patients with a prior uterine scar or cesarean delivery, or that were studies of membrane sweeping during initiation of induction of labor. Study appraisal and synthesis methods: the primary outcome was the rate of spontaneous labor. Meta-analysis was performed using the random-effects model of DerSimonian and Laird, to produce relative risk (RR) with 95% confidence interval (CI). Results: Two studies met inclusion criteria and were included in our meta-analysis (n = 361). Membrane sweeping did not have an effect on the onset of labor (RR 1.05, 95% CI 0.92–1.20). There was no significant difference for the rate of spontaneous vaginal delivery (RR 1.06, 95% CI 0.84–1.34), operative vaginal delivery (RR 0.97, 95% CI 0.25–3.78), or cesarean delivery (RR 1.00, 95% CI 0.87–1.14). Conclusion: Membrane sweeping in patients planning a trial of labor after cesarean was not found to be effective in promoting the onset of labor. This systematic review highlights the limited data addressing the utility of membrane sweeping for women with prior cesarean delivery.

Published
2019
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261. Potent Apoptotic Response Induced by Chloroacetamidine Anthrathiophenediones in Bladder Cancer Cells

Author

Susanna Cogoi, Sonia Zorzet, Andrey E. Shchekotikhin, Luigi E. Xodo, Cogoi, S., Zorzet, Sonia, Shchekotikhin, A. E., and Xodo, L. E.

Subjects
experimental model, Antineoplastic Agents, Apoptosis, Chloroacetamidine-Anthrathiophenedione, Thiophenes, urologic and male genital diseases, Acetamides, Alleles, Animals, Biological Transport, Cell Line, Tumor, Cell Proliferation, Cyclin D1, Drug Design, G-Quadruplexes, G2 Phase Cell Cycle Checkpoints, Genes, ras, Humans, Mice, Substrate Specificity, Survival Analysis, Urinary Bladder Neoplasms, Xenograft Model Antitumor Assays, Molecular Medicine, Drug Discovery3003 Pharmaceutical Science, Medicine (all), Cell Line, chemistry.chemical_compound, Annexin, Chloroacetamidine-Anthrathiophenediones, Bladder cancer, Drug Discovery, Propidium iodide, HRAS, ras, Caspase, Tumor, biology, Cell cycle, Genes, chemistry, Biochemistry, Cell culture, Cancer cell, biology.protein, Cancer research
Abstract

We previously found that two neighboring G-quadruplexes behave as a molecular switch controlling the expression of HRAS (Cogoi, S.; Schekotikhin, A. E.; Xodo, L. E. Nucl. Acids Res. 2014, DOI: 10.1093/nar/gku574). In this study we have designed anthrathiophenediones with two chloroacetamidine-containing side chains (CATDs) as G-quadruplex binders and have examined their anticancer activity in T24 bladder cancer cells bearing mutant HRAS and in T24 xenografts. The designed CATDs (3a-e), bearing alkyl side chains of different length, penetrate T24 cancer cells more than their analogues with guanidine-containing side chains. The lead compounds 3a and 3c inhibit HRAS expression, metabolic activity, and colony formation in T24 cancer cells. They also activate a strong apoptotic response, as indicated by PARP-1, caspases 3/7, and annexin V/propidium iodide assays. Apoptosis occurs under conditions where cyclin D1 is down-regulated and the cell cycle arrested in G2 phase. Finally, compound 3a inhibits the growth of T24 xenografts and increases the median survival time of nude mice.

Published
2015

263. (A,G)-oligonucleotides form extraordinary stable triple helices with a critical R.Y sequence of the murine c-Ki-ras promoter and inhibit transcription in transfected NIH 3T3 cells

Author

Alunni-Fabbroni, Marianna, Pirulli, Doroti, Manzini, Giorgio, and Xodo, Luigi E.

Subjects
Nucleic acids -- Analysis, Promoters (Genetics) -- Analysis, Genetic transcription -- Analysis, DNA -- Analysis, Biological sciences, Chemistry
Abstract

The capacity of the murine c-Ki-ras promoter sequence located in the 29-bp homopurine.homopyridine motif to function as a target for triplex forming oligonucleotides (TFOs) was analyzed by in vitro and in vivo experiments. The transcription activity of the critical c-Ki-ras promoter 29-bp R.Y sequence was inhibited by the TOFs. Furthermore, the inhibition of the transcriptional activity of the 29-bp R.Y sequence indicates that the region can serve as a target for G-rich oligonucleotides that form triplex complexes with A.AT and G.GC triads.

Published
1996

264. The challenge of maintaining necessary vascular and endovascular services at a referral center in Northern Italy during the COVID-19 outbreak.

Author

Piazza, M, Xodo, A, Squizzato, F, Conti, G De, Boemo, D, Carretta, G, Grego, F, and Antonello, M

Abstract

Objectives: The Padova Hospital Vascular Surgery Division is located in Veneto, one of the area of the Northern Italy most hit by the Coronavirus disease 2019 outbreak. The aim of this paper is to describe the protocols adopted and to evaluate their impact during the acute phase of Coronavirus spread, focusing on the management of elective and urgent/emergent surgery, outpatients activity, and also health staff preservation from intra-hospital Coronavirus disease 2019 infection. Methods: Several measures were progressively adopted in the Padova University Hospital to front the Coronavirus disease 2019 outbreak, with a clear strong asset established by 9 March 2020, after the Northern Italy lockdown. Since this date, the Vascular Surgery Unit started a "scaled-down" activity, both for elective surgical procedures and for the outpatient Clinical activities; different protocols were developed for health preservation of staff and patients. We compared a two months period, 30 days before and 30 days after this time point. In particular, emergent vascular surgery was regularly guaranteed as well as urgent surgery (to be performed within 24 h). Elective cases were scheduled for "non-deferrable" pathology. A swab test protocol for COVID-19 was applied to health-care professionals and hospitalized patients. Results: The number of urgent or emergent aortic cases remained stable during the two months period, while the number of Hospital admissions via Emergency Room related to critical limb ischemia decreased after national lockdown by about 20%. Elective vascular surgery was scaled down by 50% starting from 9 March; 35% of scheduled elective cases refused hospitalization during the lockdown period and 20% of those contacted for hospitalization where postponed due to fever, respiratory symptoms, or close contacts with Coronavirus disease 2019 suspected cases. Elective surgery reduction did not negatively influence overall carotid or aortic outcomes, while we reported a higher major limb amputation rate for critical limb ischemia (about 10%, compared to 4% for the standard practice period). We found that 4 out of 98 (4%) health-care providers on the floor had an asymptomatic positive swab test. Among 22 vascular doctors, 3 had a confirmed Coronavirus disease 2019 infection (asymptomatic); a total of 72 swab were performed (mean = 3.4 swab/person/month) during this period; no cases of severe Coronavirus disease 2019 (deaths or requiring intensive care treatment) infection were reported within this period for the staff or hospitalized patients. Conclusions: Elective vascular surgery needs to be guaranteed as possible during Coronavirus disease 2019 outbreak. The number of truly emergent cases did not reduce, on the other side, Emergency Room accesses for non-emergent cases decreased. Our preliminary results seem to describe a scenario where, if the curve of the outbreak in the regional population is flattened, in association with appropriate hospitals containment rules, it may be possible to continue the activity of the Vascular Surgery Units and guarantee the minimal standard of care. [ABSTRACT FROM AUTHOR]

Published
2021
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266. Improving Italian general practice training: the role of academia

Author

John H. Lange, Luca Cegolon, Carla Xodo, William C. Heymann, Cegolon, L., Heymann, W. C., Lange, J. H., and Xodo, C.

Subjects
Family medicine, Certification of Italian as a Foreign Language, Specialty, Bursary, Lira, General practice training, 03 medical and health sciences, family medicine, 0302 clinical medicine, Nursing, Academic primary care, European Union, Italy, Post graduate specialist training, Research, Practice & Policy, media_common.cataloged_instance, Medicine, 030212 general & internal medicine, European union, general practice training, post graduate specialist training, media_common, lcsh:R5-920, Government, research, business.industry, 030503 health policy & services, academic primary care, Certificate, Supreme court, lcsh:Medicine (General), 0305 other medical science, Family Practice, business
Abstract

The modern Italian national health service is a Beveridgean system centred around GPs and funded by central taxation.1,2 In order to become eligible to work as a GP, Italian doctors need to undertake a 3-year postgraduate training in general practice.3–6 The latter training — governed nationally by the Italian Ministry of Health and locally by the various Italian regions — is organised by the primary care establishment.3–6 By contrast, all other postgraduate medical specialties in Italy are organised by universities and are governed by the Ministry of Education, University and Research (MIUR). On successful conclusion of the above GP training, Italian doctors are awarded a certificate of completion of training which is then mutually recognised in all member states of the European Union (EU).3–5 Italian doctors in postgraduate university specialty training (that is, non-GP trainees) had not benefited from any financial support from the government during their training until 1991. From 1992 until 2000 a tax-free monthly studentship of about 960 000 Italian Lira was introduced to support non-GP trainees; the latter bursary then became approximately €960 from 2000 to 2006 (after the introduction the Euro currency to Italy). Proper working contracts with an annual gross salary of €22 700 (a variable monthly amount of €1600–1700 after taxes) for this category of specialist trainees started in 2007. As a result, the Italian Supreme Court recently ordered the Italian government to pay compensation to Italian doctors training for medical specialities governed by the university authority from 1 January 1983 onward, in compliance with the Directives of the Council of the EU regarding stipends of doctors during postgraduate specialist training. The latter directives were accompanied by related decisions of regional tribunals. Unfortunately, these decisions concerned only doctors in training in secondary care specialties (that is, non-GP trainees), while Italian GP trainees currently still lack working contracts for their postgraduate clinical training in …

Published
2017

267. Training in Occupational Medicine: Jurisprudential Malfunctions in the Italian System and European Perspectives

Author

Cegolon L., Heymann W. C., Xodo C., Lange J. H., Cegolon, L., Heymann, W. C., Xodo, C., and Lange, J. H.

Subjects
Acquired rights, Public health medicine, Occupational Medicine, Certification, Italy, Legal and forensic medicine, Mutual recognition, Training, European Union, Acquired right, Occupational medicine
Abstract

Background. To practice occupational health in Europe, a medical doctor must qualify in occupational medicine. This requires a period of postgraduate specialist medical training lasting a minimum of four years, in conformity with European regulations, to obtain a certificate of completion of training which is then mutually recognized within the entire European Union. Discussion. In 2002 an Italian law allowed doctors specialized in public health medicine and legal/forensic medicine to also practice as consultants in occupational medicine in the country. However a subsequent law in 2008 determined that only physicians specialized in occupational medicine could freely practice as consultants in this discipline. The other two categories (consultants in public health medicine and consultants in legal/forensic medicine) were required to undertake additional training (a Master course) to qualify as consultants in occupational medicine. Conclusions. Doctors who entered postgraduate training in public health or legal/forensic medicine before 2008, with the option to practice also as consultants in occupational medicine upon completion of their training, suffered an unprecedented and legally questionable retroactive application of this new law which stripped them of previously acquired rights. Moreover, even after qualifying by undertaking this extra training in occupational medicine, the latter two categories of doctors do not have their training recognized in other member states of the European Union. To disallow the rights of doctors qualified in occupational medicine to work as consultants in the latter medical discipline elsewhere within the European Union seems a clear violation of professional rights and, as such, legal action could be taken to submit this issue to European attention.

Published
2017

270. Travel health education

Author

Luca Cegolon, John H Lange, W C Heymann, Carla Xodo, Cegolon, L., Heymann, W. C., Lange, J. H., and Xodo, C.

Subjects
medicine.medical_specialty, business.industry, 030231 tropical medicine, MEDLINE, General Medicine, 03 medical and health sciences, 0302 clinical medicine, Nursing, Patient Education as Topic, Communicable Disease Control, Medicine, Travel medicine, Humans, Health education, 030212 general & internal medicine, business, Referral and Consultation, Travel Medicine, Human
Published
2017

271. Cervical pessary for preventing preterm birth in twin pregnancies with short cervical length: a systematic review and meta-analysis

Author

Francesco D'Antonio, Gabriele Saccone, Andrea Ciardulli, Lorraine Dugoff, Elena Olearo, Pasquale Martinelli, Giuseppe Maria Maruotti, Jack Ludmir, Vincenzo Berghella, Serena Xodo, Giuseppe Rizzo, Carmela Votino, Simona Boito, Saccone, Gabriele, Ciardulli, Andrea, Xodo, Serena, Dugoff, Lorraine, Ludmir, Jack, Dâ antonio, Francesco, Boito, Simona, Olearo, Elena, Votino, Carmela, Maruotti, Giuseppe Maria, Rizzo, Giuseppe, Martinelli, Pasquale, and Berghella, Vincenzo

Subjects
Cervical pessary, Pessary, medicine.medical_specialty, review, Cervix Uteri, transvaginal ultrasound, 03 medical and health sciences, 0302 clinical medicine, Meta-analysis, cerclage, cervix, Pregnancy, medicine, Humans, Meta-analysi, 030212 general & internal medicine, Cervix, Twin Pregnancy, Randomized Controlled Trials as Topic, Gynecology, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, Infant, Newborn, Gestational age, Obstetrics and Gynecology, Organ Size, Pessaries, medicine.disease, Cervical Length Measurement, medicine.anatomical_structure, Premature birth, Pediatrics, Perinatology and Child Health, Pregnancy, Twin, Premature Birth, Settore MED/40 - Ginecologia e Ostetricia, Female, business
Abstract

Objective: To evaluate the effectiveness of cervical pessary for preventing spontaneous preterm birth (SPTB) in twin pregnancies with an asymptomatic transvaginal ultrasound cervical length (TVU CL) in the second trimester.Methods: We performed a meta-analysis including all randomized clinical trials (RCTs) comparing the use of cervical pessary (i.e. intervention group) with expectant management (i.e. control group). The primary outcome was incidence of SPTB

Published
2017

272. Endometriosis and obstetrics complications: a systematic review and meta-analysis

Author

Miriam Acunzo, Vincenzo Berghella, Serena Xodo, Marcello Ceccaroni, Emanuela Spagnolo, Gabriele Saccone, Fabrizio Zullo, Zullo, Fabrizio, Spagnolo, Emanuela, Saccone, Gabriele, Acunzo, Miriam, Xodo, Serena, Ceccaroni, Marcello, and Berghella, Vincenzo

Subjects
Gestational hypertension, medicine.medical_specialty, Reproductive Techniques, Assisted, miscarriage, Endometriosis, outcomes, Preeclampsia, Miscarriage, 03 medical and health sciences, Reproductive Techniques, 0302 clinical medicine, Pregnancy, Humans, Medicine, 030212 general & internal medicine, Endometriosi, Obstetric Labor Complication, Gynecology, 030219 obstetrics & reproductive medicine, business.industry, Obstetrics, ultrasound, Incidence (epidemiology), Incidence, gynecology, Infant, Newborn, Pregnancy Outcome, Infant, preterm birth, Obstetrics and Gynecology, Newborn, medicine.disease, Pregnancy Complication, Obstetric Labor Complications, Placenta previa, Pregnancy Complications, Reproductive Medicine, Assisted, Female, outcome, Small for gestational age, business, Cohort study, Human
Abstract

OBJECTIVE: To evaluate the effect of endometriosis on pregnancy outcomes. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Women with or without endometriosis. INTERVENTION(S): Electronic databases searched from their inception until February 2017 with no limit for language and with all cohort studies reporting the incidence of obstetric complications in women with a diagnosis of endometriosis compared with a control group (women without a diagnosis of endometriosis) included. MEAN OUTCOME MEASURE(S): Primary outcome of incidence of preterm birth at

Published
2017

274. Photosensitizers binding to nucleic acids as anticancer agents

Author

Luigi E. Xodo, Valentina Rapozzi, and Susanna Cogoi

Subjects
B78-H1, cancer, cationic phthalocyanines, cationic porphyrins, KRAS, mRNA suppression, Panc-1, photodynamic therapy, RNA-quadruplexes, singlet oxygen, Animals, Antineoplastic Agents, DNA, G-Quadruplexes, Humans, Indoles, Neoplasms, Photochemotherapy, Photosensitizing Agents, Porphyrins, RNA, Messenger, ras Proteins, Drug Discovery3003 Pharmaceutical Science, Pharmacology, Molecular Medicine, Medicine (all), 0301 basic medicine, medicine.medical_treatment, Messenger, Photodynamic therapy, Isoindoles, medicine.disease_cause, chemistry.chemical_compound, Drug Discovery, heterocyclic compounds, Chemistry, Singlet oxygen, Biochemistry, 03 medical and health sciences, medicine, Cationic polymerization, RNA, Cancer, medicine.disease, 030104 developmental biology, Nucleic acid
Abstract

Cationic porphyrins (Prs) and phthalocyanines (Pcs) are strong photosensitizers that have drawn much attention for their potential in photodynamic therapy. These compounds have the interesting property of binding to nucleic acids, in particular G-rich quadruplex-forming sequences in DNA and RNA. In this review, we highlight their potential as anticancer drugs.

Published
2016

275. Androgen Receptor (AR) Gene (CAG)n and (GGN)n Length Polymorphisms and Symptoms in Young Males With Long-Lasting Adverse Effects After Finasteride Use Against Androgenic Alopecia

Author

Serena Xodo, Sabina Cauci, Giuseppe Toffoli, Erika Cecchin, Giovanni Chiriaco, Carlo Trombetta, Giuseppe Stinco, Cauci, Sabina, Chiriacò, Giovanni, Cecchin, Erika, Toffoli, Giuseppe, Xodo, Serena, Stinco, Giuseppe, and Trombetta, Carlo

Subjects
Endocrinology, Diabetes and Metabolism, Loss of Libido, lcsh:Medicine, Gastroenterology, CAG polymorphism, PFS, Post-Finasteride Syndrome, chemistry.chemical_compound, Behavioral Neuroscience, 0302 clinical medicine, Endocrinology, Basic Science, loss of libido, Erectile Dysfunction, androgen receptor, finasteride safety, Medicine, Finasteride Side Effect, Young male, Original Research, 030219 obstetrics & reproductive medicine, 5alpha-reductase inhibitor, post-finasteride syndrome, male pattern hair loss, AGA, GGN polymorphism, erectile dysfunction, sexual dysfunction, finasteride side effects, lcsh:Other systems of medicine, Pathophysiology, Psychiatry and Mental health, Androgen Receptor, Finasteride, Androgenic Alopecia, medicine.symptom, Psychology, Finasteride Safety, Long lasting, medicine.medical_specialty, Sexual Dysfunction, Urology, 030209 endocrinology & metabolism, Dermatology, GGN Polymorphism, 03 medical and health sciences, Internal medicine, Adverse effect, Gene, business.industry, lcsh:R, 5α-Reductase Inhibitor, medicine.disease, CAG Polymorphism, Finasteride Side Effects, Male Pattern Hair Loss, Reproductive Medicine, 2708, lcsh:RZ201-999, Discontinuation, Androgen receptor, Erectile dysfunction, Sexual dysfunction, chemistry, business, Male Pattern Hair Lo
Abstract

Introduction Long-term adverse symptoms of men who used oral finasteride against androgenic alopecia have been recently described as post-finasteride syndrome (PFS). Aim To determine whether (CAG)n-rs4045402 and (GGN)n-rs3138869 polymorphisms in the androgen receptor (AR) gene are implicated in PFS. Methods AR polymorphisms were studied according to PFS symptoms in 66 white participants (31.8% Italian, 28.8% American, and 39.4% other). Main Outcome Measures Symptoms were investigated by an ad hoc 100-item questionnaire and the Arizona Sexual Experience Scale and Aging Male Symptom Scale (AMS). (CAG)n and (GGN)n repeats were categorized as short ([CAG]9–19, [GGN]23). Results Median age was 32 years, duration of finasteride use was 360 days, and time from finasteride discontinuation was 1,053 days. We observed several frequency differences in symptoms according to (CAG)n and (GGN)n repeat numbers. Three AMS items were worse for medium (GGN)23 than for long (GGN)>23 carriers and one item was worse for short (GGN)2 kg), increased skin dryness, and onset of symptoms after finasteride use. Conclusion This study showed that short and/or long (CAG)n and (GGN)n repeats had different frequencies according to symptoms reported by patients with PFS, likely reflecting the vast array of genes modulated by the AR. This study showed a U-curvilinear profile of (CAG)n repeats for skin dryness symptoms, where the two extremes exhibited a worse condition than medium repeats. Further studies are necessary to investigate the PFS pathophysiology using a precision medicine approach.

Published
2016
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276. Why STAN might not be dead

Author

Gabriele Saccone, Ewoud Schuit, Isis Amer-Wåhlin, Vincenzo Berghella, Serena Xodo, Xodo, Serena, Saccone, Gabriele, Schuit, Ewoud, Amer-WÃ¥hlin, Isi, and Berghella, Vincenzo

Subjects
Pediatrics, medicine.medical_specialty, Cardiotocography, Fetal heart rate monitoring, labor, Nonstress test, law.invention, Fetal monitoring, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, law, Pregnancy, medicine, Humans, 030212 general & internal medicine, reproductive and urinary physiology, nonstress test, Potential impact, 030219 obstetrics & reproductive medicine, St analysis, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, STAN, Pediatrics, Perinatology and Child Health, Female, delivery, business
Abstract

Recently, a meta-analysis, including 26 526 laboring vertex singletons at term, summarized all available level-1 data from six high-quality randomized clinical trials (RCTs) on the use of ST analysis (STAN) during labor as an adjunct to conventional intrapartum fetal heart rate monitoring. The meta-analysis showed that STAN did not improve perinatal outcomes or decrease cesarean deliveries. Nonetheless, there are still reasons to believe STAN may have a role in the future research on intrapartum fetal monitoring. Out of six trials included in the meta-analysis, two included all cephalic singletons in labor, and four enrolled only high-risk pregnant women. This combination of both low- and high-risk populations may have distorted the potential impact of STAN. The test for heterogeneity between both subgroups was found to be statistically significant, indicating that the effect of STAN was different in high-risk women compared to a combination of both low- and high-risk women. Furthermore, the classifications of the fetal heart rate patterns used in the included randomized trials were different. Last but not least, despite >26 000 women with singleton gestations were included in the meta-analysis, the evidence still suffers from a lack of power, especially for subgroup analyses. In summary, while the level-1 data so far indicate overall no perinatal benefit of adding STAN to conventional intrapartum fetal heart rate monitoring for the outcomes most of interest, several issues point to the fact that more research is needed before the STAN technology can be deemed of no value for fetal monitoring in labor.

Published
2016

277. Nanocrystalline cellulose-fullerene: Novel conjugates

Author

Marco Carini, Maurizio Prato, C. Marega, Ana Herreros-López, Tommaso Carofiglio, V. La Parola, Valentina Rapozzi, Caroline Hadad, Luigi E. Xodo, T. Da Ros, Ali A. Alshatwi, HERREROS LOPEZ, ANA MARIA, Carini, Marco, DA ROS, Tatiana, Carofiglio, T., Marega, Claudia, La Parola, V., Rapozzi, Valentina, Xodo, L. E., Alshatwi, Ali A., Hadad, C, and Prato, Maurizio

Subjects
Materials Chemistry2506 Metals and Alloys, Fullerene, Polymers and Plastics, Water-soluble derivative, photooxydation, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Colloid, Materials Chemistry, Molecule, Organic chemistry, Cellulose, Fullerene C60, Photooxydation, Polymers and Plastic, Covalent functionalization, Nanocrystalline cellulose, Water-soluble derivatives, Organic Chemistry, Singlet oxygen, Nanocrystalline cellulosa, water-soluble derivatives, 021001 nanoscience & nanotechnology, Fluorescence, Combinatorial chemistry, Nanocrystalline material, 0104 chemical sciences, chemistry, Covalent bond, 0210 nano-technology
Abstract

The covalent grafting of two amino-fullerene C60 derivatives (C60-LC-NH2 and C60-SC-NH2, LC = long chain and SC = short chain) onto the surface of TEMPO oxidized nanocrystalline cellulose (NCC-COOH) has been reported for the first time. These hybrids (NCC-LC-C60 and NCC-SC-C60) form stable colloidal suspensions at concentrations up to 0.5 mg/mL and act as effective photosensitizers for singlet oxygen production as demonstrated by the oxidation of L-methionine-methyl ester to the corresponding sulphoxide. Using the same approach, in a one-pot reaction both a fluorescent target molecule (FITC-LC-NH2) and the C60-LC-NH2 derivative have been successfully attached covalently onto the NCC-COOH surface. These hybrids, which showed no cytotoxicity on MCF-7 human breast cancer cells could be good candidates in photodynamic cancer therapy.

Published
2016

278. Timing of cord clamping for blood gas analysis is of paramount importance

Author

Vincenzo Berghella, Serena Xodo, and Luigi E. Xodo

Subjects
Pregnancy, 030219 obstetrics & reproductive medicine, business.industry, Infant, Newborn, Parturition, Obstetrics and Gynecology, General Medicine, Fetal Blood, medicine.disease, Constriction, 03 medical and health sciences, 0302 clinical medicine, Anesthesia, medicine, Humans, Female, Cord clamping, 030212 general & internal medicine, Blood Gas Analysis, Cordocentesis, business, Blood gas analysis
Published
2018

280. Contributory presentations/posters

Author

Gries, A., Singh, Balwinder, Nakazawal, Chicko, Genest, D., Getzoff, E. D., Matsuo, H., Kaur, Harpreet, Borst, J. W., Chadha, K. C., Tingyun, Kuang, Jagannadham, M. V., Leijon, Mikael, Sato, S., Bhakuni, Vlnod, Vijayan, M., Surolia, A., Suguna, K., Manoj, N., Srinivas, V. R., Ravishankar, R., Laggner, P., Prassl, R., Schwarzenbacher, R., Zeth, K., Kostner, G. M., Taylor, Susan S., Xuong, Nguyen-huu, Akamine, Pearl, Sagar, Bidva M., Saikrishnan, K., Purnapatre, K., Handa, P., Roy, S., Varshney, U., Biswal, B. K., Sukumar, N., Rao, J. K. Mohana, Johnson, A., Pattabhi, Vasantha, Murthy, M. R. N., Krishna, Sri S., Savithri, H. S., Sastri, Mira, Hosur, M. V., Pillai, Bindu, Kannan, K. K., Kumar, Mukesh, Patwardhan, Swati, Padmanabhaa, B., Sasaki-Sugio, S., Matsuzaki, T., Nukaga, M., Singh, T. P., Sharma, A. K., Srinivasan, A., Khan, J. A., Paramasivam, M., Kumar, P., Karthikevan, S., Sharma, S., Yadav, S., Srintvasan, A., Alam, Neelima, Gourinath, S., Kaur, Punit, Chandra, Vikas, Betzel, Ch., Ghosh, S., Bera, A. K., Pal, A. K., Baneriee, Asok, Mukhopadhyay, B. P., Bhattacharya, S., Chakraborty, S., Haldar, U., Dey, I., Solovicova, Adriana, Sevcik, Jozef, Sekar, K., Sundaralingam, M., Genov, N., Liang, Dong-cai, Zhang, Ji-ping, Jiang, Tao, Chang, Wen-rui, Blommers, Marcel, Jahnke, Wolfgang, Hosur, R. V., Panchal, S. C., Pillay, Bindu, Jaganathan, N. R., Mathur, Puniti, Srivatsun, S., Joshi, Ratan Mani, Chauhan, V. S., Govil, Girjesh, Atreya, H. S., Sahu, S. C., Quinjou, Éric, Adjadj, Elisabeth, Mispelter, Joël, Izadi-Pruneyre, Nadia, Blouquit, Yves, Heyd, Bernadette, Lerat, Guilhem, Desmadreil, Michel, Milnard, Philippe, Lin, Y., Rao, B. D. Nageswara, Raghunathan, Vidva, Chau, Mei H., Coutinho, Evans, Pesais, Prashant, Srivastava, Sudha, Saran, Anil, Srikrishnan, Thamarapu, Lijima, Herbert, Gesme, Jayson, Sapico, Leizl F., Paxton, Raymond, Grace, C. R., Nagenagowda, G., Lynn, A. M., Cowsik, Sudha M., Govil, G., Sahu, Sarata C., Bhattacharya, A., Chauhan, S., Kumar, Anil, Zuiderweg, Erik R. P., Pellecchia, Maurizio, Nitta, Katsutoshi, Ohnishi, Atsushi, Kawano, Keiichi, Hikichi, Kunio, Fujitani, Naoki, Ohkubo, Tadayasu, Aizawa, Tomoyasu, Kumaki, Yasuhiro, Hayakawa, Yoichi, Parvathy, Rani V., Kini, R. M., Nakagawa, Astushi, Tanaka, Isao, Demura, Makoto, Yao, Min, Koshiba, Takumi, Kobashigawa, Yoshihiro, Kuwajima, Kunihiro, Linge, Jens, Nilges, Michael, Donoghue, Seán O., Chakshusmathi, G., Ratnaparkhi, Girish S., Madhu, P. K., Varadarajan, R., Tetreau, C., Tourbez, M., Lavalette, D., Bulone, D., Manno, M., Emanuele, A., Palma-Vittorelli, M. B., Palma, M. U., Vaiana, S. M., Martorana, V., Biagio, P. L. San, Chang, D. 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C., Neagu, Monica, Neagu, Adrian, Janežič, Dušanka, Praprotnik, Matej, Nilsson, Lennart, Mark, Pekka, Fata, La L., Dardenne, Laurent E., Werneck, Araken S., Neto, Marçal de O., Kannan, N., Vishveshwara, S., Veluraja, K., Opitz, David, Balasubramanian, Krishnan, Gute, Brian D., Mills, Denise, Lungeanu, Diana, Mihalas, G. I., Macovievici, G., Gruia, Raluca, Dalcin, B., Cortez-Maghelly, C., Passos, E. P., Ljubisavljevic, M., Blesic, S., Milosevic, S., Stratimirovic, D. J., Bachhawat, Nandita, Mande, Shekhar C., Nandy, A., Nishigaki, Koichi, Saito, Ayumu, Naimuddin, Mohammed, Takaesu, Hirotomo, Ono, Mitsuo, Hirokawa, Takatsugu, Eissa, A. M., Ahmed, Abdalla S., El Gohary, M. I., Nakashima, Hiroshi, Raghava, G. P. S., Kurgalvuk, N., Goryn, O., Gerstman, Bernard S., Kratasyuk, V. A., Esimbekova, E. N., Gritsenko, E. V., Remmel, N. N., Maznyak, O. M., German, A., Tikhonov, A., Tchitchkan, D., Koulchitsky, S., Pashkevich, S., Pletnev, S., Kulchitsky, V., Pesotskaya, Y., Shapiro, Erik M., Borthakur, Arijitt, Dimitrov, Ivan, Leigh, John S., Rizi, Rahim, Reddy, Ravinder, Charagundla, Sridhar, Duvvuri, Umamaheswar, Degaonkar, M., Khubchandani, M., Kumar, Mahesh, Jagannathan, N R., Raghunathan, P., Jayasundar, Rama, Coshic, O., Rath, O. K., Julka, P. K., Iliescu, Karina Roxana, Sajin, Maria, Petcu, Ileana, Moisoi, Nicolcta, Kuzmenko, A. I., Donchenko, G. V., Nikolenko, I. A., Morozova, R. P., Rahman, M. K., Ahmed, M. M., Watanabe, Takehiro, Uretzky, G., Ammar, R., Sharony, R., Rubin, Y., Gilboa, H., Mallick, H. N., Kumar, Mohan V., Begum, Gulnaz M., Degaonkar, Mahaveer N., Govindasamy, S., Kumosani, T. A., Lupusoru, C., Titescu, G., Haulica, I., Stefanescu, I., Iliescu, R., Nastasa, V., Bild, W., Khetawat, Gopal, Nealen, M., Faraday, N., Bray, P. F., Noga, S., Lycholat, E. A., Ananieva, T. V., Kosevich, M V., Stepanyan, S. G., Antonyuk, S. V., Khachatryan, A., Kumar, A., Arakelian, H., Khachatryan, R., Agadjanyan, S., Ayrapetyan, S., Mkheyan, V., Rajan, S. S., Kabaleeswaran, V., Gopalakrishnan, Geetha, Govindachari, T. R., Ramrakhiani, Meera, Cullen, David C., Lowe, Phillip, Badley, Andrew, Hermel, H., Möhwald, H., Schmahl, W., Singh, Anil K., Das, Joydip, Majumdar, Nirmalya, Dér, András, Oroszi, László, Kelemen, Loránd, Ormos, Pál, Hámori, András, Ramsden, Jeremy J., Mitra, Chanchal K., Savitri, D., Yanagida, Toshio, Esaki, Seiji, Sowa, Yosiyuki, Nishida, Tomoyuki, Kimura, Yuji, Radu, M., Laukhina, E. E., Kasumova, L. A., Koltover, V. K., Bubnov, V. P., Estrin, Ya. I., Dotta, Rajiv, Zahradník, Ivan, Marko, Milan, Novák, Pavel, Miyata, Hidetake, Hirata, Hiroaki, Sengupta, P., Maiti, S., Balaji, J., Banerjee, S., Barker, A. L., Winlove, C. P., OʼHare, D., Macpherson, J. V., Gonsalves, M., Unwin, P. R., Phillip, R., Kumar, Ravindra G., Murata, K., Nagayaka, K., Danev, R., Sugitani, S., Gősch, Michael, Thyberg, P., Földes-Papp, Z., Björk, G., Blom, H., Holm, J., Heino, T., Inagaki, Fuyuhiko, Yokochi, Masashi, Kusunoki, Masami, Matthews, E. K., Pines, J., Chukova, Yu. P., Koltover, Vitaly K., Kang, B. P. S., Bansal, Geetanjali, Bansal, M. P., Singh, U., Singh, Uma, Nakata, Kotoko, Nakano, Tastuya, Kaminuma, Tsuguchika, Kirn, Bonn, Potocnik, Neja, Stare, Vito, Shukla, Latal, Sastry, M. D., Natarajan, V., Devasagayam, T. P. A., Kesavan, P. C., Sayfutdinov, R., Degermendzhy, A. G., Adamovich, V. V., Rogozin, Yu. D., Khetrapal, C. L., Gowda, G. A. Nagana, Ghimire, Kedar Nath, Masaru, Ishida, Fujita, H., Ishiwata, S., Suzuki, M., Kawahara, S., Kirino, Y., Kishimoto, Y., Mori, H., Mishina, M., Ohshima, H., Dukhin, A. S., Goetz, P. J., Shilov, V. N., and Mishra, R. K.

Published
1999
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282. Preoperative Endovascular Procedures and Succinate Dehydrogenase (SDH) Genetic Screening as Useful Methods to Improve Surgical Outcomes in Patients with Neck Paragangliomas (NPs)

Author

Michele Piazza, Andrea Xodo, Mirko Menegolo, Riccardo Bozza, Franco Grego, and Michele Antonello

Subjects
medicine.medical_specialty, biology, business.industry, Succinate dehydrogenase, biology.protein, medicine, Surgery, In patient, Radiology, Cardiology and Cardiovascular Medicine, business
Published
2019

283. Tools

Author

Menegolo, Mirko, Xodo, Andrea, Maturi, Carlo, Antonello, Michele, and Grego, Franco

Published
2018

285. Comparison of Two Different Techniques for Isolated Left Subclavian Artery Revascularization During Thoracic Endovascular Aortic Repair in Zone 2

Author

Gabriele Piffaretti, Giovanni Pratesi, Guido Gelpi, Mario Galli, Frank J. Criado, Michele Antonello, Federico Fontana, Filippo Piacentino, Edoardo Macchi, Matteo Tozzi, Patrizio Castelli, Matteo Barbante, Arnaldo Ippoliti, Claudia Romagnoni, Carlo Antona, Anita Paggi, Andrea Xodo, and Franco Grego

Subjects
Male, Time Factors, medicine.medical_treatment, Thoracic, thoracic aortic aneurysm, Subclavian Artery, 030204 cardiovascular system & hematology, 0302 clinical medicine, Postoperative Complications, Risk Factors, Nuclear Medicine and Imaging, 80 and over, Medicine, 030212 general & internal medicine, left subclavian artery, Aged, 80 and over, Type B aortic dissection, Endovascular Procedures, Chimney graft, thoracic aortic disease, type B aortic dissection, Middle Aged, Aortic Aneurysm, carotid-subclavian bypass, chimney graft, endoleak, intramural hematoma, LSA preservation, mortality, reintervention, thoracic endovascular aortic repair, Treatment Outcome, Italy, Female, Radiology, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Surgery, Radiology, Nuclear Medicine and Imaging, Aortic repair, Revascularization, Thoracic aortic aneurysm, 03 medical and health sciences, Blood Vessel Prosthesis Implantation, Young Adult, Intramural hematoma, Aged, Aneurysm, Dissecting, Aortic Aneurysm, Thoracic, Blood Vessel Prosthesis, Humans, Retrospective Studies, Radiology, Nuclear Medicine and imaging, business.industry, medicine.disease, Aneurysm, Settore MED/22, Aortic Dissection, Left subclavian artery, business, Carotid subclavian bypass, Dissecting
Abstract

Purpose: To analyze the results of isolated left subclavian artery (LSA) revascularization during thoracic endovascular aortic repair (TEVAR) using carotid-subclavian bypass (CSbp) or chimney grafts (CGs). Methods: A retrospective multicenter, observational study identified 73 patients (mean age 68±13 years, range 22–87; 56 men) with acute or chronic thoracic aortic lesions who underwent TEVAR with isolated LSA revascularization using either CSbp (n=42) or CGs (n=31) from January 2010 and February 2017. Primary endpoints were TEVAR-related mortality, postoperative stroke, freedom from type Ia endoleak, and LSA patency. Results: Primary technical success was achieved in all cases. Early TEVAR-related mortality was 4.2% (CSbp 2% vs CG 6%, p=0.571). Two (3%) patients had major ischemic strokes (one in each group). Mean follow-up was 24±21 months (range 1–72; median 15). Estimated freedom from TEVAR-related mortality was 93%±3% (95% CI 84.3% to 97.0%) at 12 and 36 months, with no significant difference between CSbp and CG (p=0.258). Aortic reintervention did not differ between the groups (CSbp 5% vs CG 6%, p=0.356); nor did freedom from type Ia endoleak (CSbp 98% vs CG 87%, p=0.134). Gutter-related endoleaks occurred in 4 (13%) CG patients, but none of the patients experienced sac enlargement or the need for reintervention and none died. Primary patency of the LSA was 100% for the entire group during the observation period. Conclusion: In our experience, LSA revascularization proved most satisfactory and equally effective with both the CSbp and CG techniques, without discernible differences at midterm follow-up.

Published
2018

287. Elderly patient: which vascular access? Choice and management of vascular access in the elderly patient

Author

Marianna Alessi, Andrea Xodo, Mirko Menegolo, Barbara Rossi, Michele Antonello, Lorenzo Antonio Calò, C. Maturi, Franco Grego, and Francesca Simioni

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, medicine.medical_treatment, Population, 030232 urology & nephrology, Vascular access, Arteriovenous fistula, 030204 cardiovascular system & hematology, lcsh:Diseases of the genitourinary system. Urology, lcsh:RC870-923, medicine.disease, Comorbidity, humanities, 03 medical and health sciences, 0302 clinical medicine, Medicine, Hemodialysis, Risks and benefits, business, Elderly patient, Intensive care medicine, education, Balance (ability)
Abstract

The optimal vascular access for elderly patients remains a challenge due to the difficult balance between risks and benefits in a population with increased comorbidity and decreased survival. Long dependence to central vein catheter, patient comorbidities, life expectancy, and complication rates are important influencing the indications for arteriovenous fistula or an arteriovenous graft. Although central vein catheters are simpler way to start a hemodialysis treatment, elderly patients are also at higher risk of death from infection or other complications associated with them more than for younger patients. The discussion revolves around the following key questions: What are the limiting factors for a vascular access in the elderly patients? Central venous catheter—is it still an option for elderly patients? Is still the autologous arteriovenous fistula playing a pivotal role as hemodialysis access in the elderly patients? Are there any real surgical contraindication to perform a vascular access in elderly patients? Is the old age a limiting factor for the vascular access management?

Published
2018

289. MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Author

Raffaella Picco, Jesper Wengel, Giulia Miglietta, Luigi E. Xodo, Stefan Vogel, and Annalisa Ferino

Subjects
0301 basic medicine, Pancreatic ductal adenocarcinoma, AGO2, KRAS, miR-216b, PDAC cells, POPC liposome, Molecular Biology, Cell Biology, endocrine system diseases, Carcinoma, Pancreatic Ductal/genetics, Lipids/chemistry, Biology, medicine.disease_cause, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Cell Proliferation/genetics, Pancreatic cancer, MicroRNAs/chemistry, Cell Line, Tumor, microRNA, medicine, Argonaute Proteins/genetics, Humans, 3' Untranslated Regions, Pancreas, Cell Proliferation, Pancreas/metabolism, medicine.disease, Nanoparticles/administration & dosage, Lipids, digestive system diseases, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Neoplastic/genetics, MicroRNAs, 030104 developmental biology, 3' Untranslated Regions/genetics, Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors, Cancer cell, Argonaute Proteins, Liposomes, Cancer research, Nanoparticles, Mir 216b, Liposomes/chemistry, Carcinoma, Pancreatic Ductal, Research Paper
Abstract

Datasets reporting microRNA expression profiles in normal and cancer cells show that miR-216b is aberrantly downregulated in pancreatic ductal adenocarcinoma (PDAC). We found that KRAS, whose mutant G12D allele drives the pathogenesis of PDAC, is a target of miR-216b. To suppress oncogenic KRAS in PDAC cells, we designed single-stranded (ss) miR-216b mimics with unlocked nucleic acid (UNA) modifications to enhance their nuclease resistance. We prepared variants of ss-miR-216b mimics with and without a 5ʹ phosphate group. Both variants strongly suppressed oncogenic KRAS in PDAC cells and inhibited colony formation in pancreatic cancer cells. We observed that the designed ss-miR-216b mimics engaged AGO2 to promote the silencing of KRAS. We also tested a new delivery strategy based on the use of palmityl-oleyl-phosphatidylcholine (POPC) liposomes functionalized with ss-miR-216b conjugated with two palmityl chains and a lipid-modified cell penetrating peptide (TAT). These versatile nanoparticles suppressed oncogenic KRAS in PDAC cells.

Published
2018
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298. Tattoo removal in the typical adolescent

Author

Mazzoleni Francesco F, Xodo Carla C, Baldo Vincenzo, Cegolon Luca, and Mastrangelo Giuseppe

Subjects
survey, epidemiology, tattoo removal, piercing, secondary school adolescents, health education, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
Abstract

Abstract Background Although popular tattoos are often regretted later on for different reasons. Nevertheless, tattoo removal is a complicated and costly procedure seldom providing satisfactory results. The aim of this study was to investigate the awareness of the implications of tattoo removal among a substantial sample of Italian secondary school adolescents. Findings Students were recruited by a stratified convenience sample and surveyed by a self administered questionnaire. Logistic regression analysis was performed, reporting adjusted Odds Ratios (OR), with 95% Confidence Interval (CI). 4,277 pupils returned a usable questionnaire. Piercings were more frequently undertaken than tattoos. Only 40% of the respondents were aware of the issues related to tattoo removal. Males and pupils with younger fathers were less likely to be aware, whereas students satisfied with their physical appearance and those with a positive attitude towards body art were more likely to be aware. Conclusions Male adolescents with younger fathers can be regarded as the ideal target of corporate health education programs driven by school counsellors and primary care physicians.

Published
2011
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299. Intrapartum cardiotocography with and without computer analysis: a systematic review and meta-analysis of randomized controlled trials

Author

Campanile, Marta, primary, D’Alessandro, Pietro, additional, Della Corte, Luigi, additional, Saccone, Gabriele, additional, Tagliaferri, Salvatore, additional, Arduino, Bruno, additional, Esposito, Giuseppina, additional, Esposito, Francesca Giovanna, additional, Raffone, Antonio, additional, Signorini, Maria Gabriella, additional, Magenes, Giovanni, additional, Di Tommaso, Mariarosaria, additional, Xodo, Serena, additional, Zullo, Fulvio, additional, and Berghella, Vincenzo, additional

Published
2018
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300. Comparison of Two Different Techniques for Isolated Left Subclavian Artery Revascularization During Thoracic Endovascular Aortic Repair in Zone 2

Author

Piffaretti, Gabriele, primary, Pratesi, Giovanni, additional, Gelpi, Guido, additional, Galli, Mario, additional, Criado, Frank J., additional, Antonello, Michele, additional, Fontana, Federico, additional, Piacentino, Filippo, additional, Macchi, Edoardo, additional, Tozzi, Matteo, additional, Castelli, Patrizio, additional, Barbante, Matteo, additional, Ippoliti, Arnaldo, additional, Romagnoni, Claudia, additional, Antona, Carlo, additional, Paggi, Anita, additional, Xodo, Andrea, additional, and Grego, Franco, additional

Published
2018
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