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812 results on '"Xiao, Wei-Lie"'

258. Wuweizidilactones A–F: Novel Highly Oxygenated Nortriterpenoids with Unusual Skeletons Isolated from Schisandra chinensis

Author

Huang, Sheng‐Xiong, primary, Yang, Li‐Bin, additional, Xiao, Wei‐Lie, additional, Lei, Chun, additional, Liu, Jing‐Pin, additional, Lu, Yang, additional, Weng, Zhi‐Ying, additional, Li, Li‐Mei, additional, Li, Rong‐Tao, additional, Yu, Jun‐Lin, additional, Zheng, Qi‐Tai, additional, and Sun, Han‐Dong, additional

Published
2007
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260. ent-Abietane diterpenoids from Isodon rubescens var. rubescens

Author

Huang, Sheng-Xiong, primary, Pu, Jian-Xin, additional, Xiao, Wei-Lie, additional, Li, Li-Mei, additional, Weng, Zhi-Ying, additional, Zhou, Yan, additional, Han, Quan-Bin, additional, Peng, Shu-Lin, additional, Ding, Li-Sheng, additional, Lou, Li-Guang, additional, and Sun, Han-Dong, additional

Published
2007
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261. Lignans from Schisandra propinqua var. propinqua

Author

Lei, Chun, primary, Huang, Sheng-Xiong, additional, Chen, Ji-Jun, additional, Pu, Jian-Xin, additional, Yang, Li-Bin, additional, Zhao, Yong, additional, Liu, Jin-Ping, additional, Gao, Xue-Mei, additional, Xiao, Wei-Lie, additional, and Sun, Han-Dong, additional

Published
2007
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262. Chemical constituents from Euphorbia wallichii and their biological activities.

Author

Yang, Da-Song, Peng, Wei-Bing, Yang, Yong-Ping, Liu, Ke-Chun, Li, Xiao-Li, and Xiao, Wei-Lie

Abstract

One rare diterpenoid which was an unusual phorbol derivative possessing a 5-ene-7-oxo functional group, wallichiioid A (1), and 17 known compounds (2–18) were isolated from the aerial parts of Euphorbia wallichii. The structures and relative configuration of these compounds were elucidated on the basis of extensive spectroscopic interpretation. All the known compounds were isolated from E. wallichii for the first time. Diterpenoids 1–5 were tested for their cytotoxicity against five cancer cell lines (A-549, MCF-7, Hep G2, HeLa, and P388) and showed IC50 values in the range of 8.19–29.72 μg/mL. The antiangiogenic activities of diterpenoids 1–5 were also evaluated using a zebrafish model. [ABSTRACT FROM AUTHOR]

Published
2015
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263. Triterpenoids from the Schisandraceae family: an update.

Author

Shi, Yi-Ming, Xiao, Wei-Lie, Pu, Jian-Xin, and Sun, Han-Dong

Subjects
*TRITERPENOIDS, *SCHISANDRACEAE, *CHEMICAL synthesis, *BIOCHEMICAL mechanism of action, *CHEMICAL structure, *BOTANICAL chemistry
Abstract

Covering: February 2008 to May 2014. Previous review: Nat. Prod. Rep., 2008, 25, 871–891 Several significant advances in the field of phytochemistry were made between 2008 and 2014 because of the high level of interest in Schisandraceae triterpenoids. In addition to a dramatic increase in the number of newly identified triterpenoids, the first complete synthesis of a schinortriterpenoid was accomplished. There has also been substantial progress in investigations of biological activity and mechanism of action. In this update, we review more than 250 new triterpenoids and describe their structures, classifications, biogenetic pathways, syntheses, and bioactivities. [ABSTRACT FROM AUTHOR]

Published
2015
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265. 7,8-Secolignans from the fruits of Schisandra neglecta.

Author

Wang, Huan, Yang, Juan-Xia, Lou, Jie, Liu, Gui-You, Li, Li-Mei, Sun, Han-Dong, Xiao, Wei-Lie, Hu, Qiu-Fen, and Gao, Xue-Mei

Subjects
VIRUS disease drug therapy, CHROMATOGRAPHIC analysis, ANTIVIRAL agents, BIOLOGICAL assay, LIGNANS, MASS spectrometry, MOLECULAR structure, NUCLEAR magnetic resonance spectroscopy, RESEARCH funding, RNA viruses, PLANT extracts, DESCRIPTIVE statistics
Abstract

Two new 7,8-secolignans, neglectahenols E and F (1 and 2), together with four known 7,8-secolignans (3–6), were isolated from the fruits of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1–6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 μM. Compounds 1 and 6 showed high anti-TMV activities with inhibition rates of 38.2% and 32.7%, respectively. These rates are higher than that of a positive control. Compounds 2–5 also showed modest anti-TMV activities with inhibition rates in the range of 22.8–28.7%. These rates are close to that of a positive control. [ABSTRACT FROM AUTHOR]

Published
2015
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271. Cytotoxicent-Kauranoids fromIsodon parvifolius

Author

Li, Li-Mei, primary, Li, Guo-You, additional, Li, Sheng-Hong, additional, Weng, Zhi-Ying, additional, Xiao, Wei-Lie, additional, Han, Quan-Bin, additional, Ding, Li-Sheng, additional, Lou, Li-Guang, additional, and Sun, Han-Dong, additional

Published
2006
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281. ent-Kaurane Diterpenoids from Isodon albopilosus

Author

Huang, Sheng-Xiong, primary, Zhao, Qin-Shi, additional, Xu, Gang, additional, Xiao, Wei-Lie, additional, Li, Rong-Tao, additional, Hou, Ai-Jun, additional, Peng, Shu-Lin, additional, Ding, Li-Sheng, additional, and Sun, Han-Dong, additional

Published
2005
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289. Kadcoccinic Acids A–J, Triterpene Acids from Kadsura coccinea

Author

Liang, Cheng-Qin, Shi, Yi-Ming, Wang, Wei-Guang, Hu, Zheng-Xi, Li, Yan, Zheng, Yong-Tang, Li, Xiao-Nian, Du, Xue, Pu, Jian-Xin, Xiao, Wei-Lie, Zhang, Hong-Bin, and Sun, Han-Dong

Abstract

Eleven triterpene acids including 10 new compounds (kadcoccinic acids A–J, 1–10) were isolated from the stems of Kadsura coccinea. Except for 10, these compounds feature a rearranged lanostane skeleton with a 6/6/5/6 tetracyclic ring system, and compounds 1and 2are the first examples of 2,3-seco-6/6/5/6-fused tetracyclic triterpenoids. Their structures were established primarily by spectroscopic and spectrometric methods. Additionally, the absolute configuration of 3was determined by single-crystal X-ray diffraction. Several of the compounds isolated were tested for their anti-HIV-1 and cytotoxic activities.

Published
2015
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290. Three minor new compounds from the aerial parts of Leonurus japonicus

Author

Zhong, Wei-Mao, Cui, Zhao-Meng, Liu, Zhi-Ke, Yang, Yan, Wu, Da-Rong, Liu, Shao-Hua, Long, Hui, Sun, Han-Dong, Dang, Yong-Jun, and Xiao, Wei-Lie

Abstract

Phytochemical investigation of the aerial parts of Leonurus japonicusled to the isolation of one new labdane diterpenoid (1) and two new ionone derivatives (2and 3), together with seven known diterpenoids (4–10). Selected isolates were evaluated their effects on Jurkat IL2 secretion.

Published
2015
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292. Minor Prenylated Flavonoids from the Twigs of Macarangaadenanthaand Their Cytotoxic Activity

Author

Yang, Da-Song, Wang, Shuang-Mei, Peng, Wei-Bing, Yang, Yong-Ping, Liu, Ke-Chun, Li, Xiao-Li, and Xiao, Wei-Lie

Abstract

Three new minor prenylated flavonoids, named macadenanthins A–C (1–3), together with three known ones (4–6), were isolated from the twigs of Macaranga adenantha. Their structures were elucidated on the basis of extensive spectroscopic analysis including NMR, UV and MS. The prenyl moieties in compounds 1–3were further modified by cyclization and hydroxylation. The new compounds were tested for their cytotoxicity against four cancer cell lines (MCF-7, Hep G2, Hela and P388) and showed IC50values in the range of 13.76–22.27 μM.

Published
2015
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293. Identification of a dibenzocyclooctadiene lignan as a HIV-1 non-nucleoside reverse transcriptase inhibitor

Author

Han, Ying-Shan, Xiao, Wei-Lie, Xu, Hongtao, Kramer, Victor G, Quan, Yudong, Mesplède, Thibault, Oliveira, Maureen, Colby-Germinario, Susan P, Sun, Han-Dong, and Wainberg, Mark A

Abstract

Background Due to resistance to all classes of anti-HIV drugs and drug toxicity, there is a need for the discovery and development of new anti-HIV drugs.Methods HIV-1 inhibitors were identified and biologically characterized for mechanism of action.Results We identified a dibenzocyclooctadiene lignan, termed HDS2 that possessed anti-HIV activity against a wide variety of viral strains with EC50values in the 1–3 µM range. HDS2 was shown to act as an NNRTI by qPCR and in vitro enzyme assays.Conclusions This compound provides a new scaffold for further optimization of activity through structure-guided design.

Published
2015
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294. Five New Nortriterpenoids from the Stems of Schisandra neglecta.

Author

Liang, Cheng-Qin, Hu, Jing, Shi, Yi-Ming, Shang, Shan-Zhai, Du, Xue, Zhan, Rui, Wang, Wei-Guang, Xiong, Wen-Yong, Xiao, Wei-Lie, Zhang, Hong-Bin, and Sun, Han-Dong

Abstract

Five new nortriterpenoids, schicagenins D-F ( 1- 3, resp.) and negleschidilactones A and B ( 4 and 5, resp.), together with eleven known ones, were isolated from the stems of Schisandra neglecta. Their structures were established on the basis of extensive spectroscopic analyses. All the compounds were evaluated for their activities regarding insulin sensitivity in 3T3-L1 differentiated adipocytes. None of them showed a significant bioactivity at 10 μ M concentration. [ABSTRACT FROM AUTHOR]

Published
2013
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295. Development of a fluorescence-based HIV-1 integrase DNA binding assay for identification of novel HIV-1 integrase inhibitors.

Author

Han, Ying-Shan, Xiao, Wei-Lie, Quashie, Peter K., Mesplède, Thibault, Xu, Hongtao, Deprez, Eric, Delelis, Olivier, Pu, Jian-Xin, Sun, Han-Dong, and Wainberg, Mark A.

Subjects
*FLUORESCENCE microscopy, *INTEGRASES, *DNA-binding proteins, *VIRUS-induced enzymes, *SERUM albumin, *REVERSE transcriptase, *ANTIVIRAL agents
Abstract

Highlights: [•] Inhibiting HIV-1 integrase (IN) DNA binding is a way to develop new anti-HIV drugs. [•] The first high-throughput assay is developed to screen IN DNA binding inhibitors. [•] The economical assay shows good agreements with results obtained by other assays. [•] A new IN binding inhibitor nigranoic acid was identified using this assay. [•] Provide a proof-of-concept of using the strategy to develop new drugs against HIV. [Copyright &y& Elsevier]

Published
2013
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298. Triterpenes from Isodon xerophilus.

Author

LI, Li-Mei, PU, Jian-Xin, XIAO, Wei-Lie, and SUN, Han-Dong

Abstract

Abstract: Aim: To investigate the chemical constituents of Isodon xerophilus. Methods: The constituents were isolated by various chromatographic methods, and the chemical structures were elucidated on the basis of spectral analyses. Their cytotoxicity was evaluated by the MTT method in 96-well microplates. Results: Ten triterpenes were isolated and identified as oleanolic acid (1), ursolic acid (2), maslinic acid (3), 2α-hydroxyursolic acid (4), hederagenin (5), 3β, 23-dihydroxy-urs-12-en-28-oic acid (6), arjunolic acid (7), asiatic acid (8), 2α, 3α, 24-trihydroxyolean-12-en-28-oic acid (9), and 2α, 3α, 24-trihydroxyurs-12-en-28-oic acid (10). All compounds were tested against three human tumor cell lines, K562, MKN45, and HepG2. Conclusion: All of the compounds were isolated from this plant for the first time. The proposed biosynthetic pathway of these triterpenes was discussed. All of the triterpenes showed noncytotoxic activity against the above-mentioned three human tumor cell lines. [Copyright &y& Elsevier]

Published
2012
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299. Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells.

Author

Liu, Chuan-Xu, Yin, Qian-Qian, Zhou, Hu-Chen, Wu, Ying-Li, Pu, Jian-Xin, Xia, Li, Liu, Wei, Huang, Xin, Jiang, Tao, Wu, Ming-Xuan, He, Li-Cai, Zhao, Ya-Xue, Wang, Xiao-Lin, Xiao, Wei-Lie, Chen, Hong-Zhuan, Zhao, Qian, Zhou, Ai-Wu, Wang, Li-Shun, Sun, Han-Dong, and Chen, Guo-Qiang

Subjects
PEROXIREDOXINS, LEUKEMIA, DITERPENES, MYELOID leukemia, CYSTEINE, PEROXIDASE, TRETINOIN
Abstract

Peroxiredoxins (Prxs) are potential therapeutic targets for major diseases such as cancers. However, isotype-specific inhibitors remain to be developed. We report that adenanthin, a diterpenoid isolated from the leaves of Rabdosia adenantha, induces differentiation of acute promyelocytic leukemia (APL) cells. We show that adenanthin directly targets the conserved resolving cysteines of Prx I and Prx II and inhibits their peroxidase activities. Consequently, cellular H2O2 is elevated, leading to the activation of extracellular signal-regulated kinases and increased transcription of CCAAT/enhancer-binding protein ?, which contributes to adenanthin-induced differentiation. Adenanthin induces APL-like cell differentiation, represses tumor growth in vivo and prolongs the survival of mouse APL models that are sensitive and resistant to retinoic acid. Thus, adenanthin can serve as what is to our knowledge the first lead natural compound for the development of Prx I- and Prx II-targeted therapeutic agents, which may represent a promising approach to inducing differentiation of APL cells. [ABSTRACT FROM AUTHOR]

Published
2012
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300. Synthesis and Biological Evaluation of Laxiflorin J Derivatives as Potential Antitumor Agents.

Author

Liu, Jing-Ping, Zhang, Hong-Bin, Huang, Sheng-Xiong, Pu, Jian-Xin, Xiao, Wei-Lie, Zhang, Xue-Ping, Xiao, Wen-Ding, Lei, Chun, and Sun, Han-Dong

Subjects
CHEMICAL derivatives, ANTINEOPLASTIC agents, DRUG synergism, CANCER cells, CHEMICAL inhibitors, EUPHORBIACEAE
Abstract

Laxiflorin J, isolated from the leaves of Isodon eriocalyx var. laxiflora, showed significant inhibitory activity toward T-24 cells. A series of laxiflorin J derivatives were synthesized and their in vitro activity was evaluated against BEL-7402, A-549, HT-29, HL-60, MOLT-4 tumor cell lines, with IC50 values ranging from 1.3 to 42.2 μg mL−1. [ABSTRACT FROM AUTHOR]

Published
2012
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