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Additional file 4: Figure S1. The expression of seven IRSS genes between normal and tumor.

Additional file 3: Figure S3. Riskscore validation.

Additional file 9: Figure S6. Correlation between immune cells and seven genes in TCGA. MAPT and NROB1 have no Significant correlation wirh immune cells in TCGA.

Understanding the variations of water cycle on orbital timescale and their response to astronomical parameters, greenhouse gases (GHG) and ice sheets is one of the focuses in paleoclimate study. Sea ice and precipitation, two important components of the water cycle, are paid much attention. A better understanding of their variations on orbital timescale, especially their response to external forcing and related processes and feedbacks, could provide insight on their long-term variations in the future. The latest research results show that, on orbital scale, the Arctic sea ice is more sensitive to insolation, while the Southern Ocean sea ice is more sensitive to GHG. Under the combined influence of insolation and GHG, the last nine interglacials all have much less summer Arctic sea ice, as compared to both the present-day and the future, due to the much higher Northern Hemisphere (NH) summer insolation. As compared to the future, the last nine interglacials all have much more annual and seasonal Southern Ocean sea ice due to their much lower CO2. In terms of the astronomical parameters, the Arctic sea ice is more influenced by precession, whereas obliquity plays a more important role in the Southern Ocean sea ice. The different responses of Arctic and Southern Ocean sea ice to astronomical parameters and CO2 are mainly due to their different geographical locations. The Arctic ocean is relatively closed and it is located in the northern highest latitudes, which make it only receives very little insolation during winter and it is mainly influenced by precession-dominated summer insolation. The summer insolation not only influences the summer Arctic sea ice, but also has an effect on the winter one through the summer remnant effect. In addition, the Arctic sea ice is also affected by the vegetation in the northern mid and high latitudes, which is mainly dominated by precession. As compared to the Arctic, the latitudes of Southern Ocean are lower and it is more open, which make it is more sensitive to the annual insolation and CO2. The relative effect of precession, obliquity and CO2 on precipitation largely depends on different regions and time periods. The tropical precipitation changes also show obvious half-precession cycles in response to the maximum equatorial insolation. In addition, astronomically-induced slow variation of insolation can trigger abrupt changes of the Atlantic meridional circulation (AMOC) through sea ice-ocean interactions in the Labrador and Nordic Seas, consequently leading to abrupt oscillations in large-scale temperature and precipitation. In East Asia, the summer precipitation in the northern part is more influenced by insolation, with a dominant precession signal. Precession-dominated insolation can influence the atmospheric circulation through its effect on the land-sea thermal contrast, which finally affects the summer monsoon precipitation. However, the summer precipitation in the southern region is more influenced by ice sheets, by their control on the meridional movement of the Inter-tropical Convergence Zone (ITCZ). In addition, the Eurasian ice sheet can further influence the precipitation in the southern part through a south-eastwards perturbation planetary wave. Moreover, the effects of insolation and ice sheets on the summer monsoon precipitation show strong regional and nonlinear characteristics, which depend on the extent, height and location of the ice sheets and the intensity of insolation.

Additional file 7: Figure S4. Identification of consensus clusters by prognostic genes.Consensus cluster matrix for k=2 in TCGA dataset.Relative change in area under CDF curve for k=2 to 10 in TCGA dataset.Consensus clustering cumulative distribution functionfor k=2 to 10 in TCGA dataset.Consensus cluster matrix for k=2 in ICGC dataset.Relative change in area under CDF curve for k=2 to 10 in ICGC dataset.Consensus clustering cumulative distribution functionfor k=2 to 10 in ICGC dataset.Contingency table showing the consistency between clustered groups and risk groups in TCGA.Contingency table showing the consistency between clustered groups and risk groups in ICGC.

Additional file 8: Figure S8. Correlation between immune cells and 5 senescence-related genes.

Additional file 6: Figure S3. The differences in risk scores across clinical features.Age.Gender.Grade.Stage.T stage.N stage.M stage.

Additional file 5: Figure S2. Heat map results of seven IRSS genes expression levels.The expression of seven IRSS genes in the TCGA test set.The expression of seven IRSS genes in the TCGA sum set.The expression of seven IRSS genes in the ICGC validation set.

Additional file 8: Figure S5. Clustering analyses in TCGA and ICGC.PCA results for two groups of patients in TCGA.ggalluvial of two clusters in TCGA displayed the correlation between clusters, risk, and survival status.PCA results for two groups of patients in ICGC.ggalluvial of two clusters in ICGC displayed the correlation between clusters, risk, and survival status.

Additional file 4: Figure S4. t-SNE and PCA between the high- and low-risk groups in TCGA and ICGC.

Additional file 5: Figure S5. Comparison with other signatures.

Additional file 2: Figure S2. Molecular interaction networks of signature genes.

Various paleoclimate records show that the end of interglacials of the late Pleistocene was marked by abrupt cooling events. Strong abrupt cooling occurring when climate was still in a warm interglacial condition is puzzling. Our transient climate simulations for the eleven interglacial (sub)stages of the past 800,000 years show that, when summer insolation in the Northern Hemisphere (NH) high latitudes decreases to a critical value (a threshold), it triggers a strong, abrupt weakening of the Atlantic meridional overturning circulation and consequently an abrupt cooling in the NH. The mechanism involves sea ice-ocean feedbacks in the Northern Nordic Sea and the Labrador Sea (Yin et al., 2021, doi: 10.1126/science.abg1737). The insolation-induced abrupt cooling is accompanied by abrupt changes in precipitation, vegetation from low to high latitudes and in particular by abrupt snow accumulation in polar regions. The timing of the simulated abrupt events at the end of interglacials is highly consistent with those observed in marine and terrestrial records, especially with those observed in high-resolution, absolutely-dated speleothem records in Asia and Europe, which validates the model results and reveals that the astronomically-induced slow variations of insolation could trigger abrupt climate events. Our results show that the insolation threshold occurred at the end of each interglacial of the past 800,000 years, suggesting its fundamental role in terminating the warm climate conditions of the interglacials. The next insolation threshold will occur in 50,000 years, implying an exceptionally long interglacial ahead., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Additional file 6: Figure S6. The differences of Grade, Stage and T stages between high-risk group and low-risk group.

Spinal ganglioneuroma (GN) is the most benign neoplasm of neuroblastic origin. There is little knowledge about spinal GN because of sporadic cases reported. The objective of this study is to describe the clinical manifestations and long-term follow-up outcomes of spinal GN after consecutive treatment. The clinical and follow-up data of 31 patients with spinal GN receiving consecutive treatment in our institute are retrospectively analyzed. The mean age of the 31 patients was 40.39 ± 14.8 years. They were diagnosed with spinal GN and received surgical treatment in our institution between February 2012 and August 2019. Of them, 22 (71%) patients presented preoperative neurological symptoms. The mean duration from symptom onset to surgery was 19.76 ± 49.59 months. Eighteen patients received complete surgical resection and 13 patients received subtotal excision. In addition, radicotomy was performed simultaneously after sophisticated consideration in 19 patients. The follow-up period averaged 64.13 ± 22.67 months. The preoperative neurological dysfunction was improved significantly during the follow-up period in all cases. No local recurrence or malignant transformation has occurred so far. Spinal GN is a rare but benign neoplasm, and the origin of spinal GN remains controversial. With our experience, we propose that the origin of spinal GN from dorsal root ganglion should be equally considered as its counterpart of sympathetic ganglion. Complete resection is the preferred surgical strategy to avoid malignant events and recurrence. And the close postoperative follow-up observations are warranted.