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941 results on '"Vaartjes, Ilonca"'

251. Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: Results from the Asia Pacific Cohort Studies Collaboration

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Peters, Sanne A.E., Wang, Xin, Lam, Tai Hing, Kim, Hyeon Chang, Ho, Suzanne, Ninomiya, Toshiharu, Knuiman, Matthew, Vaartjes, Ilonca, Bots, Michael L., Woodward, Mark, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Peters, Sanne A.E., Wang, Xin, Lam, Tai Hing, Kim, Hyeon Chang, Ho, Suzanne, Ninomiya, Toshiharu, Knuiman, Matthew, Vaartjes, Ilonca, Bots, Michael L., and Woodward, Mark

Published
2018

252. Decline in mortality in patients with dementia: Results from a nationwide cohort of 44 258 patients in the Netherlands during 2000 to 2008

Author

Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Geriatrie, van de Vorst, Irene E., Vaartjes, Ilonca, Bots, Michiel L., Koek, Huiberdina L., Unit Opleiding Geriatrie, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Geriatrie, van de Vorst, Irene E., Vaartjes, Ilonca, Bots, Michiel L., and Koek, Huiberdina L.

Published
2018

253. Ethnic differences in cardiovascular morbidity and mortality among patients with breast cancer in the Netherlands: A register-based cohort study

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Deen, Laura, Buddeke, Josefien, Vaartjes, Ilonca, Bots, Michiel L., Norredam, Marie, Agyemang, Charles, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Deen, Laura, Buddeke, Josefien, Vaartjes, Ilonca, Bots, Michiel L., Norredam, Marie, and Agyemang, Charles

Published
2018

254. Relations between the residential fast-food environment and the individual risk of cardiovascular diseases in The Netherlands: A nationwide follow-up study

Author

Cardiovasculaire Epi Team 10, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Infectieziekten Team 3, Global Health, Poelman, Maartje, Strak, Maciej, Schmitz, Oliver, Hoek, Gerard, Karssenberg, Derek, Helbich, Marco, Ntarladima, Anna Maria, Bots, Michiel, Brunekreef, Bert, Grobbee, Rick, Dijst, Martin, Vaartjes, Ilonca, Cardiovasculaire Epi Team 10, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Infectieziekten Team 3, Global Health, Poelman, Maartje, Strak, Maciej, Schmitz, Oliver, Hoek, Gerard, Karssenberg, Derek, Helbich, Marco, Ntarladima, Anna Maria, Bots, Michiel, Brunekreef, Bert, Grobbee, Rick, Dijst, Martin, and Vaartjes, Ilonca

Published
2018

255. Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

Author

Ontwikkelingsstoornissen Med., LKCH Research Hoofdanalist, CDL Arcadia, Other research (not in main researchprogram), Cardiovasculaire Epi Team 4, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Global Health, JC onderzoeksprogramma Methodologie, Marees, Andries T., Hammerschlag, Anke R., Bastarache, Lisa, de Kluiver, Hilde, Vorspan, Florence, van den Brink, Wim, Smit, Dirk J., Denys, Damiaan, Gamazon, Eric R., Li-Gao, Ruifang, Breetvelt, Elemi J., de Groot, Mark C.H., Galesloot, Tessel E., Vermeulen, Sita H., Poppelaars, Jan L., Souverein, Patrick C., Keeman, Renske, de Mutsert, Renée, Noordam, Raymond, Rosendaal, Frits R., Stringa, Najada, Mook-Kanamori, Dennis O., Vaartjes, Ilonca, Kiemeney, Lambertus A., den Heijer, Martin, van Schoor, Natasja M., Klungel, Olaf H., Maitland-Van der Zee, Anke H., Schmidt, Marjanka K., Polderman, Tinca J.C., van der Leij, Andries R., Posthuma, Danielle, Derks, Eske M., Ontwikkelingsstoornissen Med., LKCH Research Hoofdanalist, CDL Arcadia, Other research (not in main researchprogram), Cardiovasculaire Epi Team 4, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Global Health, JC onderzoeksprogramma Methodologie, Marees, Andries T., Hammerschlag, Anke R., Bastarache, Lisa, de Kluiver, Hilde, Vorspan, Florence, van den Brink, Wim, Smit, Dirk J., Denys, Damiaan, Gamazon, Eric R., Li-Gao, Ruifang, Breetvelt, Elemi J., de Groot, Mark C.H., Galesloot, Tessel E., Vermeulen, Sita H., Poppelaars, Jan L., Souverein, Patrick C., Keeman, Renske, de Mutsert, Renée, Noordam, Raymond, Rosendaal, Frits R., Stringa, Najada, Mook-Kanamori, Dennis O., Vaartjes, Ilonca, Kiemeney, Lambertus A., den Heijer, Martin, van Schoor, Natasja M., Klungel, Olaf H., Maitland-Van der Zee, Anke H., Schmidt, Marjanka K., Polderman, Tinca J.C., van der Leij, Andries R., Posthuma, Danielle, and Derks, Eske M.

Published
2018

256. Comorbidity in cardiovascular disease: a widespread phenomenon

Author

Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Bots, Michiel, Visseren, FLJ, Vaartjes, Ilonca, van Dis, I., Buddeke, Josefien, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Bots, Michiel, Visseren, FLJ, Vaartjes, Ilonca, van Dis, I., and Buddeke, Josefien

Published
2018

257. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author

Onderzoek Precision medicine, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, Prins, Bram P., Mead, Timothy J., Brody, Jennifer A., Sveinbjornsson, Gardar, Ntalla, Ioanna, Bihlmeyer, Nathan A., van den Berg, Marten, Bork-Jensen, Jette, Cappellani, Stefania, Van Duijvenboden, Stefan, Klena, Nikolai T., Gabriel, George C., Liu, Xiaoqin, Gulec, Cagri, Grarup, Niels, Haessler, Jeffrey, Hall, Leanne M., Iorio, Annamaria, Isaacs, Aaron, Li-Gao, Ruifang, Lin, Honghuang, Liu, Ching Ti, Lyytikäinen, Leo Pekka, Marten, Jonathan, Mei, Hao, Müller-Nurasyid, Martina, Orini, Michele, Padmanabhan, Sandosh, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, van Setten, Jessica, Smith, Albert V., Verweij, Niek, Warren, Helen R., Weiss, Stefan, Alonso, Alvaro, Arnar, David O., Bots, Michiel L., de Boer, Rudolf A., Dominiczak, Anna F., Eijgelsheim, Mark, Ellinor, Patrick T., Guo, Xiuqing, Felix, Stephan B., Harris, Tamara B., Hayward, Caroline, Heckbert, Susan R., Huang, Paul L., Jukema, J. W., Kähönen, Mika, Kors, Jan A., Lambiase, Pier D., Launer, Lenore J., Li, Man, Linneberg, Allan, Nelson, Christopher P., Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce M., Raitakari, Olli T., Rice, Kenneth M., Rotter, Jerome I., Sinner, Moritz F., Soliman, Elsayed Z., Spector, Tim D., Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Vaartjes, Ilonca, van der Meer, Peter, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Wilson, James G., Xie, Zhijun, Asselbergs, Folkert W., Dörr, Marcus, van Duijn, Cornelia M., Gasparini, Paolo, Gudbjartsson, Daniel F., Gudnason, Vilmundur, Hansen, Torben, Kääb, Stefan, Kanters, Jørgen K., Kooperberg, Charles, Lehtimäki, Terho, Lin, Henry J., Lubitz, Steven A., Mook-Kanamori, Dennis O., Conti, Francesco J., Newton-Cheh, Christopher H., Rosand, Jonathan, Rudan, Igor, Samani, Nilesh J., Sinagra, Gianfranco, Smith, Blair H., Holm, Hilma, Stricker, Bruno H., Ulivi, Sheila, Sotoodehnia, Nona, Apte, Suneel S., van der Harst, Pim, Stefansson, Kari, Munroe, Patricia B., Arking, Dan E., Lo, Cecilia W., Jamshidi, Yalda, Onderzoek Precision medicine, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Team Medisch, Prins, Bram P., Mead, Timothy J., Brody, Jennifer A., Sveinbjornsson, Gardar, Ntalla, Ioanna, Bihlmeyer, Nathan A., van den Berg, Marten, Bork-Jensen, Jette, Cappellani, Stefania, Van Duijvenboden, Stefan, Klena, Nikolai T., Gabriel, George C., Liu, Xiaoqin, Gulec, Cagri, Grarup, Niels, Haessler, Jeffrey, Hall, Leanne M., Iorio, Annamaria, Isaacs, Aaron, Li-Gao, Ruifang, Lin, Honghuang, Liu, Ching Ti, Lyytikäinen, Leo Pekka, Marten, Jonathan, Mei, Hao, Müller-Nurasyid, Martina, Orini, Michele, Padmanabhan, Sandosh, Radmanesh, Farid, Ramirez, Julia, Robino, Antonietta, Schwartz, Molly, van Setten, Jessica, Smith, Albert V., Verweij, Niek, Warren, Helen R., Weiss, Stefan, Alonso, Alvaro, Arnar, David O., Bots, Michiel L., de Boer, Rudolf A., Dominiczak, Anna F., Eijgelsheim, Mark, Ellinor, Patrick T., Guo, Xiuqing, Felix, Stephan B., Harris, Tamara B., Hayward, Caroline, Heckbert, Susan R., Huang, Paul L., Jukema, J. W., Kähönen, Mika, Kors, Jan A., Lambiase, Pier D., Launer, Lenore J., Li, Man, Linneberg, Allan, Nelson, Christopher P., Pedersen, Oluf, Perez, Marco, Peters, Annette, Polasek, Ozren, Psaty, Bruce M., Raitakari, Olli T., Rice, Kenneth M., Rotter, Jerome I., Sinner, Moritz F., Soliman, Elsayed Z., Spector, Tim D., Strauch, Konstantin, Thorsteinsdottir, Unnur, Tinker, Andrew, Trompet, Stella, Uitterlinden, André, Vaartjes, Ilonca, van der Meer, Peter, Völker, Uwe, Völzke, Henry, Waldenberger, Melanie, Wilson, James G., Xie, Zhijun, Asselbergs, Folkert W., Dörr, Marcus, van Duijn, Cornelia M., Gasparini, Paolo, Gudbjartsson, Daniel F., Gudnason, Vilmundur, Hansen, Torben, Kääb, Stefan, Kanters, Jørgen K., Kooperberg, Charles, Lehtimäki, Terho, Lin, Henry J., Lubitz, Steven A., Mook-Kanamori, Dennis O., Conti, Francesco J., Newton-Cheh, Christopher H., Rosand, Jonathan, Rudan, Igor, Samani, Nilesh J., Sinagra, Gianfranco, Smith, Blair H., Holm, Hilma, Stricker, Bruno H., Ulivi, Sheila, Sotoodehnia, Nona, Apte, Suneel S., van der Harst, Pim, Stefansson, Kari, Munroe, Patricia B., Arking, Dan E., Lo, Cecilia W., and Jamshidi, Yalda

Published
2018

258. Cardiovascular Disease Prevention Policy in Human Immunodeficiency Virus: Recommendations From a Modeling Study

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Smit, Mikaela, van Zoest, Rosan A, Nichols, Brooke E, Vaartjes, Ilonca, Smit, Colette, van der Valk, Marc, van Sighem, Ard I, Wit, Ferdinand W N M, Hallett, Timothy B, Reiss, Peter, Netherlands ATHENA observational HIV cohort, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Smit, Mikaela, van Zoest, Rosan A, Nichols, Brooke E, Vaartjes, Ilonca, Smit, Colette, van der Valk, Marc, van Sighem, Ard I, Wit, Ferdinand W N M, Hallett, Timothy B, Reiss, Peter, and Netherlands ATHENA observational HIV cohort

Published
2018

260. Associations between the built environment and obesity: an umbrella review.

Author

Lam, Thao Minh, Vaartjes, Ilonca, Grobbee, Diederick E., Karssenberg, Derek, and Lakerveld, Jeroen

Subjects
*BUILT environment, *URBAN land use, *WALKABILITY, *OBESITY, *URBAN growth, *PHYSICAL activity
Abstract

Background: In the past two decades, the built environment emerged as a conceptually important determinant of obesity. As a result, an abundance of studies aiming to link environmental characteristics to weight-related outcomes have been published, and multiple reviews have attempted to summarise these studies under different scopes and domains. We set out to summarise the accumulated evidence across domains by conducting a review of systematic reviews on associations between any aspect of the built environment and overweight or obesity. Methods: Seven databases were searched for eligible publications from the year 2000 onwards. We included systematic literature reviews, meta-analyses and pooled analyses of observational studies in the form of cross-sectional, case–control, longitudinal cohort, ecological, descriptive, intervention studies and natural experiments. We assessed risk of bias and summarised results structured by built environmental themes such as food environment, physical activity environment, urban–rural disparity, socioeconomic status and air pollution. Results: From 1850 initial hits, 32 systematic reviews were included, most of which reported equivocal evidence for associations. For food- and physical activity environments, associations were generally very small or absent, although some characteristics within these domains were consistently associated with weight status such as fast-food exposure, urbanisation, land use mix and urban sprawl. Risks of bias were predominantly high. Conclusions: Thus far, while most studies have not been able to confirm the assumed influence of built environments on weight, there is evidence for some obesogenic environmental characteristics. Registration: This umbrella review was registered on PROSPERO under ID CRD42019135857. [ABSTRACT FROM AUTHOR]

Published
2021
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261. Trends of Stroke Incidence and 28-Day All-Cause Mortality after a Stroke in Malaysia: A Linkage of National Data Sources.

Author

Wen Yea Hwong, Swee Hung Ang, Bots, Michiel L., Sivasampu, Sheamini, Selvarajah, Sharmini, Wan Chung Law, Latif, Lydia Abdul, and Vaartjes, Ilonca

Abstract

Background: Data on nationwide trends for stroke metrics are crucial to understand the extent of the disease burden to a country's health system. Yet, this information remains scarce in lowand middle-income countries. Objectives: This study investigated trends of stroke incidence and 28-day all-cause mortality after a stroke from 2008 to 2016 in Malaysia, through linkage across national data sources. Methods: Hospital admissions with a principal diagnosis of stroke or transient ischemic attack were included. Cases with first stroke were identified through linkage of hospital admission registers where age and sex-standardized trends of stroke incidence and its subtypes were calculated. By linking hospital registers to the National Death Register, the 28-day all-cause mortality rates after a stroke were estimated. Mann-Kendall's test was used for trend evaluation. Results: From 243,765 records, the trend of stroke incidence showed an increase of 4.9% in men and a drop of 3.8% among women. Incidences were higher in men, at 99.1 per 100,000 population in 2008 and 103.9 per 100,000 in 2016 than women (80.3 per 100,000 in 2008 and 77.2 per 100,000 in 2016). There was a substantial increase in stroke incidence among those below 65 years old, with the largest increase of 53.3% in men aged between 35-39 years and 50.4% in women of similar age group. The trend for 28-day all-cause mortality showed a decline for men at -13.1% and women, -10.6%. Women had higher mortality from stroke (22.0% in 2008 and 19.7% in 2016) than men (19.4% in 2008 to 17.2% in 2016). Conclusion: This first empirical study on stroke trends in Malaysia revealed a worrying increase in stroke incidence among the younger population. Despite a declining trend, mortality rates remained moderately high especially in women. Comprehensive strategies to strengthen the prevention and management of stroke care are warranted. [ABSTRACT FROM AUTHOR]

Published
2021
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262. Discovery of novel heart rate-associated loci using the Exome Chip

Author

van den Berg, Marten E, Warren, Helen R, Cabrera, Claudia P, Verweij, Niek, Mifsud, Borbala, Haessler, Jeffrey, Bihlmeyer, Nathan A, Fu, Yi-Ping, Weiss, Stefan, Lin, Henry J, Grarup, Niels, Li-Gao, Ruifang, Pistis, Giorgio, Shah, Nabi, Brody, Jennifer A, Müller-Nurasyid, Martina, Lin, Honghuang, Mei, Hao, Smith, Albert V, Lyytikäinen, Leo-Pekka, Hall, Leanne M, van Setten, Jessica, Trompet, Stella, Prins, Bram P, Isaacs, Aaron, Radmanesh, Farid, Marten, Jonathan, Entwistle, Aiman, Kors, Jan A, Silva, Claudia T, Alonso, Alvaro, Bis, Joshua C, de Boer, Rudolf, de Haan, Hugoline G, de Mutsert, Renée, Dedoussis, George, Dominiczak, Anna F, Doney, Alex SF, Ellinor, Patrick T, Eppinga, Ruben N, Felix, Stephan B, Guo, Xiuqing, Hagemeijer, Yanick, Hansen, Torben, Harris, Tamara B, Heckbert, Susan R, Huang, Paul L, Hwang, Shih-Jen, Kähönen, Mika, Kanters, Jørgen K, Kolcic, Ivana, Launer, Lenore J, Li, Man, Yao, Jie, Linneberg, Allan, Liu, Simin, Macfarlane, Peter W, Mangino, Massimo, Morris, Andrew D, Mulas, Antonella, Murray, Alison D, Nelson, Christopher P, Orrú, Marco, Padmanabhan, Sandosh, Peters, Annette, Porteous, David J, Poulter, Neil, Psaty, Bruce M, Qi, Lihong, Raitakari, Olli T, Rivadeneira, Fernando, Roselli, Carolina, Rudan, Igor, Sattar, Naveed, Sever, Peter, Sinner, Moritz F, Soliman, Elsayed Z, Spector, Timothy D, Stanton, Alice V, Stirrups, Kathleen E, Taylor, Kent D, Tobin, Martin D, Uitterlinden, André, Vaartjes, Ilonca, Hoes, Arno W, van der Meer, Peter, Völker, Uwe, Waldenberger, Melanie, Xie, Zhijun, Zoledziewska, Magdalena, Tinker, Andrew, Polasek, Ozren, Rosand, Jonathan, Jamshidi, Yalda, van Duijn, Cornelia M, Zeggini, Eleftheria, Jukema, J Wouter, Asselbergs, Folkert W, Samani, Nilesh J, and Lehtimäki, Terho

Subjects
Adult, Male, Genotype, European Continental Ancestry Group, Cardiovascular, Medical and Health Sciences, White People, Gene Frequency, Clinical Research, Risk Factors, Heart Rate, Genetics, 2.1 Biological and endogenous factors, Humans, Genetic Predisposition to Disease, Exome, Aetiology, Polymorphism, Alleles, Oligonucleotide Array Sequence Analysis, Genetics & Heredity, Whites, Prevention, Human Genome, Single Nucleotide, Middle Aged, Biological Sciences, Stem Cell Research, Heart Disease, Genetic Loci, Female, Biotechnology, Genome-Wide Association Study
Abstract

Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of our study these loci explained 0.9% of the variation. This study aims to discover new genetic loci associated with heart rate from Exome Chip meta-analyses.Heart rate was measured from either elecrtrocardiograms or pulse recordings. We meta-analysed heart rate association results from 104 452 European-ancestry individuals from 30 cohorts, genotyped using the Exome Chip. Twenty-four variants were selected for follow-up in an independent dataset (UK Biobank, N = 134 251). Conditional and gene-based testing was undertaken, and variants were investigated with bioinformatics methods.We discovered five novel heart rate loci, and one new independent low-frequency non-synonymous variant in an established heart rate locus (KIAA1755). Lead variants in four of the novel loci are non-synonymous variants in the genes C10orf71, DALDR3, TESK2 and SEC31B. The variant at SEC31B is significantly associated with SEC31B expression in heart and tibial nerve tissue. Further candidate genes were detected from long-range regulatory chromatin interactions in heart tissue (SCD, SLF2 and MAPK8). We observed significant enrichment in DNase I hypersensitive sites in fetal heart and lung. Moreover, enrichment was seen for the first time in human neuronal progenitor cells (derived from embryonic stem cells) and fetal muscle samples by including our novel variants.Our findings advance the knowledge of the genetic architecture of heart rate, and indicate new candidate genes for follow-up functional studies.

Published
2017

263. Ambient air pollution and the risk of ischaemic and haemorrhagic stroke

Author

Verhoeven, Jamie I, Allach, Youssra, Vaartjes, Ilonca C H, Klijn, Catharina J M, and de Leeuw, Frank-Erik

Abstract

Stroke is a leading cause of disability and the second most common cause of death worldwide. Increasing evidence suggests that air pollution is an emerging risk factor for stroke. Over the past decades, air pollution levels have continuously increased and are now estimated to be responsible for 14% of all stroke-associated deaths. Interpretation of previous literature is difficult because stroke was usually not distinguished as ischaemic or haemorrhagic, nor by cause. This Review summarises the evidence on the association between air pollution and the different causes of ischaemic stroke and haemorrhagic stroke, to clarify which people are most at risk. The risk for ischaemic stroke is increased after short-term or long-term exposure to air pollution. This effect is most pronounced in people with cardiovascular burden and stroke due to large artery disease or small vessel disease. Short-term exposure to air pollution increases the risk of intracerebral haemorrhage, a subtype of haemorrhagic stroke, whereas the effects of long-term exposure are less clear. Limitations of the current evidence are that studies are prone to misclassification of exposure, often rely on administrative data, and have insufficient clinical detail. In this Review, we provide an outlook on new research opportunities, such as those provided by the decreased levels of air pollution due to the current COVID-19 pandemic.

Published
2021
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264. Identification of Risk of Cardiovascular Disease by Automatic Quantification of Coronary Artery Calcifications on Radiotherapy Planning CT Scans in Patients With Breast Cancer

Author

Gal, Roxanne, van Velzen, Sanne G. M., Hooning, Maartje J., Emaus, Marleen J., van der Leij, Femke, Gregorowitsch, Madelijn L., Blezer, Erwin L. A., Gernaat, Sofie A. M., Lessmann, Nikolas, Sattler, Margriet G. A., Leiner, Tim, de Jong, Pim A., Teske, Arco J., Verloop, Janneke, Penninkhof, Joan J., Vaartjes, Ilonca, Meijer, Hanneke, van Tol-Geerdink, Julia J., Pignol, Jean-Philippe, van den Bongard, Desirée H. J. G., Išgum, Ivana, and Verkooijen, Helena M.

Abstract

IMPORTANCE: Cardiovascular disease (CVD) is common in patients treated for breast cancer, especially in patients treated with systemic treatment and radiotherapy and in those with preexisting CVD risk factors. Coronary artery calcium (CAC), a strong independent CVD risk factor, can be automatically quantified on radiotherapy planning computed tomography (CT) scans and may help identify patients at increased CVD risk. OBJECTIVE: To evaluate the association of CAC with CVD and coronary artery disease (CAD) in patients with breast cancer. DESIGN, SETTING, AND PARTICIPANTS: In this multicenter cohort study of 15 915 patients with breast cancer receiving radiotherapy between 2005 and 2016 who were followed until December 31, 2018, age, calendar year, and treatment-adjusted Cox proportional hazard models were used to evaluate the association of CAC with CVD and CAD. EXPOSURES: Overall CAC scores were automatically extracted from planning CT scans using a deep learning algorithm. Patients were classified into Agatston risk categories (0, 1-10, 11-100, 101-399, >400 units). MAIN OUTCOMES AND MEASURES: Occurrence of fatal and nonfatal CVD and CAD were obtained from national registries. RESULTS: Of the 15 915 participants included in this study, the mean (SD) age at CT scan was 59.0 (11.2; range, 22-95) years, and 15 879 (99.8%) were women. Seventy percent (n = 11 179) had no CAC. Coronary artery calcium scores of 1 to 10, 11 to 100, 101 to 400, and greater than 400 were present in 10.0% (n = 1584), 11.5% (n = 1825), 5.2% (n = 830), and 3.1% (n = 497) respectively. After a median follow-up of 51.2 months, CVD risks increased from 5.2% in patients with no CAC to 28.2% in patients with CAC scores higher than 400. After adjustment, CVD risk increased with higher CAC score (hazard ratio [HR]CAC = 1-10 = 1.1; 95% CI, 0.9-1.4; HRCAC = 11-100 = 1.8; 95% CI, 1.5-2.1; HRCAC = 101-400 = 2.1; 95% CI, 1.7-2.6; and HRCAC>400 = 3.4; 95% CI, 2.8-4.2). Coronary artery calcium was particularly strongly associated with CAD (HRCAC>400 = 7.8; 95% CI, 5.5-11.2). The association between CAC and CVD was strongest in patients treated with anthracyclines (HRCAC>400 = 5.8; 95% CI, 3.0-11.4) and patients who received a radiation boost (HRCAC>400 = 6.1; 95% CI, 3.8-9.7). CONCLUSIONS AND RELEVANCE: This cohort study found that coronary artery calcium on breast cancer radiotherapy planning CT scan results was associated with CVD, especially CAD. Automated CAC scoring on radiotherapy planning CT scans may be used as a fast and low-cost tool to identify patients with breast cancer at increased risk of CVD, allowing implementing CVD risk-mitigating strategies with the aim to reduce the risk of CVD burden after breast cancer. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03206333

Published
2021
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265. Deep phenotyping meets big data: the Geoscience and hEalth Cohort COnsortium (GECCO) data to enable exposome studies in The Netherlands.

Author

Lakerveld, Jeroen, Wagtendonk, Alfred, Vaartjes, Ilonca, Karssenberg, Derek, GECCO Consortium, Penninx, Brenda, Beulens, Joline, Timmermans, Erik, Huisman, Martijn, Kramer, Sophia, van Wier, Marieke, Boomsma, Dorret, Willemsen, Gonneke, Schuengel, Carlo, Oosterman, Mirjam, Stronks, Karien, Vermeulen, Roel, Koster, Annemarie, Stehouwer, Coen, and van den Hurk, Katja

Subjects
GEOLOGY, ENVIRONMENTAL exposure, HEALTH behavior, INFORMATION superhighway, CONSORTIA
Abstract

Environmental exposures are increasingly investigated as possible drivers of health behaviours and disease outcomes. So-called exposome studies that aim to identify and better understand the effects of exposures on behaviours and disease risk across the life course require high-quality environmental exposure data. The Netherlands has a great variety of environmental data available, including high spatial and often temporal resolution information on urban infrastructure, physico-chemical exposures, presence and availability of community services, and others. Until recently, these environmental data were scattered and measured at varying spatial scales, impeding linkage to individual-level (cohort) data as they were not operationalised as personal exposures, that is, the exposure to a certain environmental characteristic specific for a person. Within the Geoscience and hEalth Cohort COnsortium (GECCO) and with support of the Global Geo Health Data Center (GGHDC), a platform has been set up in The Netherlands where environmental variables are centralised, operationalised as personal exposures, and used to enrich 23 cohort studies and provided to researchers upon request. We here present and detail a series of personal exposure data sets that are available within GECCO to date, covering personal exposures of all residents of The Netherlands (currently about 17 M) over the full land surface of the country, and discuss challenges and opportunities for its use now and in the near future. [ABSTRACT FROM AUTHOR]

Published
2020
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267. A prediction model for one- and three-year mortality in dementia: results from a nationwide hospital-based cohort of 50,993 patients in the Netherlands.

Author

Vorst, Irene E van de, Golüke, Nienke M S, Vaartjes, Ilonca, Bots, Michiel L, and Koek, Huiberdina L

Subjects
MORTALITY risk factors, AGE distribution, ELDER care, CONFIDENCE intervals, CAUSES of death, DEMENTIA, HOSPITAL care, HOSPITAL admission & discharge, LONGITUDINAL method, PATIENTS, RISK assessment, SEX distribution, STATISTICS, DECISION making in clinical medicine, ADVANCE directives (Medical care), COMORBIDITY, LOGISTIC regression analysis, DATA analysis
Abstract

Objective to develop a model to predict one- and three-year mortality in patients with dementia attending a hospital, through hospital admission or day/memory clinic. Design we constructed a cohort of dementia patients through data linkage of three Dutch national registers: the hospital discharge register (HDR), the population register and the national cause of death register. Subjects patients with dementia in the HDR aged between 60 and 100 years registered between 1 January 2000 and 31 December 2010. Methods logistic regression analysis techniques were used to predict one- and three-year mortality after a first hospitalisation with dementia. The performance was assessed using the c-statistic and the Hosmer–Lemeshow test. Internal validation was performed using bootstrap resampling. Results 50,993 patients were included in the cohort. Two models were constructed, which included age, sex, setting of care (hospitalised versus day clinic) and the presence of comorbidity using the Charlson comorbidity index. One model predicted one-year mortality and the other three-year mortality. Model discrimination according to the c-statistic for the models was 0.71 (95% CI 0.71–0.72) and 0.72 (95% CI 0.72–0.73), respectively. Conclusion both models display acceptable ability to predict mortality. An important advantage is that they are easy to apply in daily practise and thus are helpful for individual decision-making regarding diagnostic/therapeutic interventions and advance care planning. [ABSTRACT FROM AUTHOR]

Published
2020
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269. Risk factors of mortality in older patients with dementia in psychiatric care.

Author

Golüke, Nienke M.S., Geerlings, Mirjam I., Vorst, Irene E., Vaartjes, Ilonca H., Jonghe, Annemarieke, Bots, Michiel L., Koek, Huiberdina L., van de Vorst, Irene E, and de Jonghe, Annemarieke

Subjects
MENTAL health services, DEMENTIA patients, OLDER patients, PROPORTIONAL hazards models, INPATIENT care, SENILE dementia
Abstract

Objective: To examine the mortality risk, and its risk factors, of older patients with dementia in psychiatric care.Methods: We constructed a cohort of dementia patients through data linkage of four Dutch registers: the Psychiatric Case Register Middle Netherlands (PCR-MN), the hospital discharge register, the population register, and the national cause of death register. All dementia patients in PCR-MN aged between 60 and 100 years between 1 January 2000 and 31 December 2010 were included. Risk factors of mortality were investigated using Cox proportional hazard regression models with adjustment for age, sex, setting of care, nationality, marital status, dementia type, and psychiatric and somatic comorbidities.Results: In total, 4297 patients were included with a median age of 80 years. The 1-year, 3-year, and 5-year mortality were 16.4%, 44.4%, and 63.5%, respectively. Determinants that increased the 1-year mortality were: male sex (adjusted hazard ratio [HR]: 1.49; 95% confidence interval [95% CI], 1.26-1.76), higher age (HR 1.08; 95% CI, 1.07-1.09), inpatient psychiatric care (HR 1.52; 95% CI, 1.19-1.93), more somatic comorbidities (HR 1.67; 95% CI, 1.49-1.87), and cardiovascular disease separately (HR 1.54; 95% CI, 1.30-1.82). Results for 3-year and 5-year mortality were comparable. Living together/married increased the 3- and 5-year mortality, and Dutch nationality increased the 5-year mortality. There were no differences in mortality with different types of psychiatric comorbidity.Conclusion: Mortality of dementia patients in psychiatric care was high, much higher than mortality in the general older population. The results of this study should raise awareness about their unfavourable prognosis, particularly older patients, men, inpatients, and patients with more somatic comorbidity. [ABSTRACT FROM AUTHOR]

Published
2020
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270. A Global Analysis of Associations between Fine Particle Air Pollution and Cardiovascular Risk Factors: Feasibility Study on Data Linkage.

Author

Min Zhao, Hoek, Gerard, Strak, Maciej, Grobbee, Diederick E., Graham, Ian, Klipstein-Grobusch, Kerstin, and Vaartjes, Ilonca

Abstract

Background: This paper presents a feasibility study of data linkage between global air pollution data and clinical medical data to assess the associations of PM2.5 with cardiovascular risk factors. Methods: Cardiovascular risk factor data were obtained from the SUrvey of Risk Factors (SURF) for coronary heart disease (CHD) patients from 10 countries in Europe, Asia, and the Middle- East. Annual average PM2.5 concentrations were estimated using recent global WHO PM2.5 maps combining satellite and surface monitoring data for the location of the 71 participating centers. Associations of PM2.5 with risk factors were assessed by mixed-effect generalized estimation equation models adjusted by sex, age, exercise, body mass index, and smoking. In the final model there was further adjustment for country. Results: Linkage between cardiovascular risk factor data and PM2.5 via the postal address of participating hospitals was shown to be feasible, however with several limitations noted. Eight thousand three hundred and ninety two patients (30% women) were included. Globally, an increase of 10 μg/m³ in PM2.5 was significantly associated with decreased BP and increased glucose. After controlling for country, an increase of 10 μg/m³ in PM2.5 was associated with decreased BP and increased LDL (SBP: -0.45 mmHg [95% CI: -0.85, -0.06]; DBP: -0.47 mmHg [-0.73, -0.20]; LDL: 0.04 mmol/L [0.01, 0.08]). The association with glucose attenuated (0.08 mmol/L [-0.23, 0.16]). Conclusion: It is feasible to link PM2.5 and cardiovascular risk factors but it is still challenging to interpret these observed associations due to unavailability of potential confounders. After country adjustment, PM2.5 was associated with small increases in LDL and small decreases in BP. Highlights: - There are limited studies on the association between air pollution and cardiovascular risk factors for patients with established coronary heart disease in low- and middle-income countries; - Data linkage is an efficient and cost-effective method to maximize the use of existing data to investigate more health related research questions; - It is feasible to determine global associations of air pollution and cardiovascular risk factors by data linkage but it is still challenging in terms of interpretation. [ABSTRACT FROM AUTHOR]

Published
2020
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272. Relations between the residential fast-food environment and the individual risk of cardiovascular diseases in The Netherlands: A nationwide follow-up study

Author

Poelman, Maartje, primary, Strak, Maciej, additional, Schmitz, Oliver, additional, Hoek, Gerard, additional, Karssenberg, Derek, additional, Helbich, Marco, additional, Ntarladima, Anna-Maria, additional, Bots, Michiel, additional, Brunekreef, Bert, additional, Grobbee, Rick, additional, Dijst, Martin, additional, and Vaartjes, Ilonca, additional

Published
2018
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275. Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

Author

Prins, Bram P., primary, Mead, Timothy J., additional, Brody, Jennifer A., additional, Sveinbjornsson, Gardar, additional, Ntalla, Ioanna, additional, Bihlmeyer, Nathan A., additional, van den Berg, Marten, additional, Bork-Jensen, Jette, additional, Cappellani, Stefania, additional, Van Duijvenboden, Stefan, additional, Klena, Nikolai T., additional, Gabriel, George C., additional, Liu, Xiaoqin, additional, Gulec, Cagri, additional, Grarup, Niels, additional, Haessler, Jeffrey, additional, Hall, Leanne M., additional, Iorio, Annamaria, additional, Isaacs, Aaron, additional, Li-Gao, Ruifang, additional, Lin, Honghuang, additional, Liu, Ching-Ti, additional, Lyytikäinen, Leo-Pekka, additional, Marten, Jonathan, additional, Mei, Hao, additional, Müller-Nurasyid, Martina, additional, Orini, Michele, additional, Padmanabhan, Sandosh, additional, Radmanesh, Farid, additional, Ramirez, Julia, additional, Robino, Antonietta, additional, Schwartz, Molly, additional, van Setten, Jessica, additional, Smith, Albert V., additional, Verweij, Niek, additional, Warren, Helen R., additional, Weiss, Stefan, additional, Alonso, Alvaro, additional, Arnar, David O., additional, Bots, Michiel L., additional, de Boer, Rudolf A., additional, Dominiczak, Anna F., additional, Eijgelsheim, Mark, additional, Ellinor, Patrick T., additional, Guo, Xiuqing, additional, Felix, Stephan B., additional, Harris, Tamara B., additional, Hayward, Caroline, additional, Heckbert, Susan R., additional, Huang, Paul L., additional, Jukema, J. W., additional, Kähönen, Mika, additional, Kors, Jan A., additional, Lambiase, Pier D., additional, Launer, Lenore J., additional, Li, Man, additional, Linneberg, Allan, additional, Nelson, Christopher P., additional, Pedersen, Oluf, additional, Perez, Marco, additional, Peters, Annette, additional, Polasek, Ozren, additional, Psaty, Bruce M., additional, Raitakari, Olli T., additional, Rice, Kenneth M., additional, Rotter, Jerome I., additional, Sinner, Moritz F., additional, Soliman, Elsayed Z., additional, Spector, Tim D., additional, Strauch, Konstantin, additional, Thorsteinsdottir, Unnur, additional, Tinker, Andrew, additional, Trompet, Stella, additional, Uitterlinden, André, additional, Vaartjes, Ilonca, additional, van der Meer, Peter, additional, Völker, Uwe, additional, Völzke, Henry, additional, Waldenberger, Melanie, additional, Wilson, James G., additional, Xie, Zhijun, additional, Asselbergs, Folkert W., additional, Dörr, Marcus, additional, van Duijn, Cornelia M., additional, Gasparini, Paolo, additional, Gudbjartsson, Daniel F., additional, Gudnason, Vilmundur, additional, Hansen, Torben, additional, Kääb, Stefan, additional, Kanters, Jørgen K., additional, Kooperberg, Charles, additional, Lehtimäki, Terho, additional, Lin, Henry J., additional, Lubitz, Steven A., additional, Mook-Kanamori, Dennis O., additional, Conti, Francesco J., additional, Newton-Cheh, Christopher H., additional, Rosand, Jonathan, additional, Rudan, Igor, additional, Samani, Nilesh J., additional, Sinagra, Gianfranco, additional, Smith, Blair H., additional, Holm, Hilma, additional, Stricker, Bruno H., additional, Ulivi, Sheila, additional, Sotoodehnia, Nona, additional, Apte, Suneel S., additional, van der Harst, Pim, additional, Stefansson, Kari, additional, Munroe, Patricia B., additional, Arking, Dan E., additional, Lo, Cecilia W., additional, and Jamshidi, Yalda, additional

Published
2018
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276. Exploring the role of low-frequency and rare exonic variants in alcohol and tobacco use

Author

Marees, Andries T., primary, Hammerschlag, Anke R., additional, Bastarache, Lisa, additional, de Kluiver, Hilde, additional, Vorspan, Florence, additional, van den Brink, Wim, additional, Smit, Dirk J., additional, Denys, Damiaan, additional, Gamazon, Eric R., additional, Li-Gao, Ruifang, additional, Breetvelt, Elemi J., additional, de Groot, Mark C.H., additional, Galesloot, Tessel E., additional, Vermeulen, Sita H., additional, Poppelaars, Jan L., additional, Souverein, Patrick C., additional, Keeman, Renske, additional, de Mutsert, Renée, additional, Noordam, Raymond, additional, Rosendaal, Frits R., additional, Stringa, Najada, additional, Mook-Kanamori, Dennis O., additional, Vaartjes, Ilonca, additional, Kiemeney, Lambertus A., additional, den Heijer, Martin, additional, van Schoor, Natasja M., additional, Klungel, Olaf H., additional, Maitland-Van der Zee, Anke H., additional, Schmidt, Marjanka K., additional, Polderman, Tinca J.C., additional, van der Leij, Andries R., additional, Posthuma, Danielle, additional, and Derks, Eske M., additional

Published
2018
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277. Clustering of risk factors and the risk of incident cardiovascular disease in Asian and Caucasian populations: results from the Asia Pacific Cohort Studies Collaboration

Author

Peters, Sanne A E, primary, Wang, Xin, additional, Lam, Tai-Hing, additional, Kim, Hyeon Chang, additional, Ho, Suzanne, additional, Ninomiya, Toshiharu, additional, Knuiman, Matthew, additional, Vaartjes, Ilonca, additional, Bots, Michael L, additional, and Woodward, Mark, additional

Published
2018
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279. Long-term exposure to particulate matter, NO2 and the oxidative potential of particulates and diabetes prevalence in a large national health survey

Author

Strak, Maciek, Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, Hoek, Gerard, Strak, Maciek, Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, and Hoek, Gerard

Abstract

BACKGROUND: The evidence from observational epidemiological studies of a link between long-term air pollution exposure and diabetes prevalence and incidence is currently mixed. Some studies found the strongest associations of diabetes with fine particles, other studies with nitrogen dioxide and some studies found no associations.OBJECTIVES: Our aim was to investigate associations between long-term exposure to multiple air pollutants and diabetes prevalence in a large national survey in the Netherlands.METHODS: We performed a cross-sectional analysis using the 2012 Dutch national health survey to investigate the associations between the 2009 annual average concentrations of multiple air pollutants (PM10, PM2.5, PM10-2.5, PM2.5 absorbance, OP(DTT), OP(ESR) and NO2) and diabetes prevalence, among 289,703 adults. Air pollution exposure was assessed by land use regression models. Diabetes was defined based on a combined measure of self-reported physician diagnosis and medication prescription from an external database. Using logistic regression, we adjusted for potential confounders, including neighborhood- and individual socio-economic status and lifestyle-related risk factors such as smoking habits, alcohol consumption, physical activity and BMI.RESULTS: After adjustment for potential confounders, all pollutants (except PM2.5) were associated with diabetes prevalence. In two-pollutant models, NO2 and OP(DTT) remained associated with increased diabetes prevalence. For NO2 and OP(DTT), single-pollutant ORs per interquartile range were 1.07 (95% CI: 1.05, 1.09) and 1.08 (95% CI: 1.05, 1.10), respectively. Stratified analysis showed no consistent effect modification by any of the included known diabetes risk factors.CONCLUSIONS: Long-term residential air pollution exposure was associated with diabetes prevalence in a large health survey in the Netherlands, strengthening the evidence of air pollution being an important diabetes risk factor. Mos

Published
2017

283. Chance of surgery in adult congenital heart disease

Author

Verheugt, Carianne L., Uiterwaal, Cuno S.P.M., Vaartjes, Ilonca, Van Der Velde, Enno T., Zomer, A. C., Meijboom, Folkert J., Pieper, Petronella G, Post, Marco C., Vliegen, Hubert W, Hazekamp, Mark G., Grobbee, Diederick E., Mulder, Barbara J M, Verheugt, Carianne L., Uiterwaal, Cuno S.P.M., Vaartjes, Ilonca, Van Der Velde, Enno T., Zomer, A. C., Meijboom, Folkert J., Pieper, Petronella G, Post, Marco C., Vliegen, Hubert W, Hazekamp, Mark G., Grobbee, Diederick E., and Mulder, Barbara J M

Published
2017

285. Long-term exposure to particulate matter, NO2 and the oxidative potential of particulates and diabetes prevalence in a large national health survey

Author

Strak, Maciej, Veldhorst-Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, Hoek, Gerard, Strak, Maciej, Veldhorst-Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, and Hoek, Gerard

Published
2017

289. Long-term exposure to particulate matter, NO2 and the oxidative potential of particulates and diabetes prevalence in a large national health survey

Author

dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Landscape functioning, Geocomputation and Hydrology, Strak, Maciek, Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, Hoek, Gerard, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Landscape functioning, Geocomputation and Hydrology, Strak, Maciek, Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, and Hoek, Gerard

Published
2017

290. Sex differences in risk factor management of coronary heart disease across three regions

Author

Global Health team 1, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 9, MS Interne Geneeskunde, Global Health, Zhao, Min, Vaartjes, Ilonca, Graham, Ian, Grobbee, Diederick, Spiering, Wilko, Klipstein-Grobusch, Kerstin, Woodward, Mark, Peters, Sanne A.E., Global Health team 1, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovascular Health, Cardiovasculaire Epi Team 9, MS Interne Geneeskunde, Global Health, Zhao, Min, Vaartjes, Ilonca, Graham, Ian, Grobbee, Diederick, Spiering, Wilko, Klipstein-Grobusch, Kerstin, Woodward, Mark, and Peters, Sanne A.E.

Published
2017

291. Ethnic Variations in Prognosis of Patients with Dementia: A Prospective Nationwide Registry Linkage Study in The Netherlands

Author

MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Agyemang, Charles, van de Vorst, Irene E, Koek, Huiberdina L, Bots, Michiel L, Seixas, Azizi, Norredam, Marie, Ikram, Umar, Stronks, Karien, Vaartjes, Ilonca, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Agyemang, Charles, van de Vorst, Irene E, Koek, Huiberdina L, Bots, Michiel L, Seixas, Azizi, Norredam, Marie, Ikram, Umar, Stronks, Karien, and Vaartjes, Ilonca

Published
2017

292. Discovery of novel heart rate-associated loci using the Exome Chip

Author

UMC Utrecht, Onderzoek Precision medicine, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epidemiology & Health Economics, Team Medisch, van den Berg, Marten E, Warren, Helen R., Cabrera, Claudia P, Verweij, Niek, Mifsud, Borbala, Haessler, Jeffrey, Bihlmeyer, Nathan A., Fu, Yi-Ping, Weiss, Stefan, Lin, Henry J, Grarup, Niels, Li-Gao, Ruifang, Pistis, Giorgio, Shah, Nabi, Brody, Jennifer A., Müller-Nurasyid, Martina, Lin, Honghuang, Mei, Hao, Smith, Albert V., Lyytikäinen, Leo-Pekka, Hall, Leanne M, van Setten, Jessica, Trompet, Stella, Prins, Bram P, Isaacs, Aaron, Radmanesh, Farid, Marten, Jonathan, Entwistle, Aiman, Kors, Jan A, Silva, Claudia T, Alonso, Alvaro, Bis, Joshua C., de Boer, Rudolf A., de Haan, Hugoline G., de Mutsert, Renée, Dedoussis, George, Dominiczak, Anna F., Doney, Alex S. F., Ellinor, Patrick T, Eppinga, Ruben N, Felix, Stephan B., Guo, Xiuqing, Hagemeijer, Yanick, Hansen, Torben, Harris, Tamara B., Heckbert, Susan R, Huang, Paul L, Hwang, Shih-Jen, Kähönen, Mika, Kanters, Jørgen K, Kolcic, Ivana, Launer, Lenore J., Li, Man, Yao, Jie, Linneberg, Allan, Liu, Simin, Macfarlane, Peter W, Mangino, Massimo, Morris, Andrew D., Mulas, Antonella, Murray, Alison D, Nelson, Christopher P., Orrú, Marco, Padmanabhan, Sandosh, Peters, Annette, Porteous, David J., Poulter, Neil, Psaty, Bruce M., Qi, Lihong, Raitakari, Olli T., Rivadeneira, Fernando, Roselli, Carolina, Rudan, Igor, Sattar, Naveed, Sever, Peter S., Sinner, Moritz F, Soliman, Elsayed Z, Spector, Timothy D, Stanton, Alice V., Stirrups, Kathleen E, Taylor, Kent D., Tobin, Martin D, Uitterlinden, André G., Vaartjes, Ilonca, Hoes, Arno W., Van der Meer, Peter, Völker, Uwe, Waldenberger, Melanie, Xie, Zhijun, Zoledziewska, Magdalena, Tinker, Andrew, Polasek, Ozren, Rosand, Jonathan, Jamshidi, Yalda, Van Duijn, Cornelia M., Zeggini, Eleftheria, Jukema, J. Wouter, Asselbergs, Folkert W., Samani, Nilesh J., Lehtimäki, Terho, Gudnason, Vilmundur, Wilson, James G., Lubitz, Steven A., Kääb, Stefan, Sotoodehnia, Nona, Caulfield, Mark J., Palmer, Colin N. A., Sanna, Serena, Mook-Kanamori, Dennis O, Deloukas, Panos, Pedersen, Oluf, Rotter, Jerome I., Dörr, Marcus, O'Donnell, Chris J, Hayward, Caroline, Arking, Dan E., Kooperberg, Charles, van der Harst, Pim, Eijgelsheim, Mark, Stricker, Bruno H., Munroe, Patricia B., UMC Utrecht, Onderzoek Precision medicine, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epidemiology & Health Economics, Team Medisch, van den Berg, Marten E, Warren, Helen R., Cabrera, Claudia P, Verweij, Niek, Mifsud, Borbala, Haessler, Jeffrey, Bihlmeyer, Nathan A., Fu, Yi-Ping, Weiss, Stefan, Lin, Henry J, Grarup, Niels, Li-Gao, Ruifang, Pistis, Giorgio, Shah, Nabi, Brody, Jennifer A., Müller-Nurasyid, Martina, Lin, Honghuang, Mei, Hao, Smith, Albert V., Lyytikäinen, Leo-Pekka, Hall, Leanne M, van Setten, Jessica, Trompet, Stella, Prins, Bram P, Isaacs, Aaron, Radmanesh, Farid, Marten, Jonathan, Entwistle, Aiman, Kors, Jan A, Silva, Claudia T, Alonso, Alvaro, Bis, Joshua C., de Boer, Rudolf A., de Haan, Hugoline G., de Mutsert, Renée, Dedoussis, George, Dominiczak, Anna F., Doney, Alex S. F., Ellinor, Patrick T, Eppinga, Ruben N, Felix, Stephan B., Guo, Xiuqing, Hagemeijer, Yanick, Hansen, Torben, Harris, Tamara B., Heckbert, Susan R, Huang, Paul L, Hwang, Shih-Jen, Kähönen, Mika, Kanters, Jørgen K, Kolcic, Ivana, Launer, Lenore J., Li, Man, Yao, Jie, Linneberg, Allan, Liu, Simin, Macfarlane, Peter W, Mangino, Massimo, Morris, Andrew D., Mulas, Antonella, Murray, Alison D, Nelson, Christopher P., Orrú, Marco, Padmanabhan, Sandosh, Peters, Annette, Porteous, David J., Poulter, Neil, Psaty, Bruce M., Qi, Lihong, Raitakari, Olli T., Rivadeneira, Fernando, Roselli, Carolina, Rudan, Igor, Sattar, Naveed, Sever, Peter S., Sinner, Moritz F, Soliman, Elsayed Z, Spector, Timothy D, Stanton, Alice V., Stirrups, Kathleen E, Taylor, Kent D., Tobin, Martin D, Uitterlinden, André G., Vaartjes, Ilonca, Hoes, Arno W., Van der Meer, Peter, Völker, Uwe, Waldenberger, Melanie, Xie, Zhijun, Zoledziewska, Magdalena, Tinker, Andrew, Polasek, Ozren, Rosand, Jonathan, Jamshidi, Yalda, Van Duijn, Cornelia M., Zeggini, Eleftheria, Jukema, J. Wouter, Asselbergs, Folkert W., Samani, Nilesh J., Lehtimäki, Terho, Gudnason, Vilmundur, Wilson, James G., Lubitz, Steven A., Kääb, Stefan, Sotoodehnia, Nona, Caulfield, Mark J., Palmer, Colin N. A., Sanna, Serena, Mook-Kanamori, Dennis O, Deloukas, Panos, Pedersen, Oluf, Rotter, Jerome I., Dörr, Marcus, O'Donnell, Chris J, Hayward, Caroline, Arking, Dan E., Kooperberg, Charles, van der Harst, Pim, Eijgelsheim, Mark, Stricker, Bruno H., and Munroe, Patricia B.

Published
2017

293. Suboptimal primary and secondary cardiovascular disease prevention in HIV-positive individuals on antiretroviral therapy

Author

Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van Zoest, Rosan A, van der Valk, Marc, Wit, Ferdinand W N M, Vaartjes, Ilonca, Kooij, Katherine W., Hovius, Joppe W., Prins, Maria, Reiss, Peter, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van Zoest, Rosan A, van der Valk, Marc, Wit, Ferdinand W N M, Vaartjes, Ilonca, Kooij, Katherine W., Hovius, Joppe W., Prins, Maria, and Reiss, Peter

Published
2017

294. Prescription of secondary preventive drugs after ischemic stroke: Results from the Malaysian National Stroke Registry

Author

UMC Utrecht, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epi Team 7, ZL Cerebrovasculaire Ziekten Medisch, Brain, Hwong, Wen Yea, Abdul Aziz, Zariah, Sidek, Norsima Nazifah, Bots, Michiel L., Selvarajah, Sharmini, Kappelle, L. Jaap, Sivasampu, Sheamini, Vaartjes, Ilonca, UMC Utrecht, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Circulatory Health, Cardiovasculaire Epi Team 7, ZL Cerebrovasculaire Ziekten Medisch, Brain, Hwong, Wen Yea, Abdul Aziz, Zariah, Sidek, Norsima Nazifah, Bots, Michiel L., Selvarajah, Sharmini, Kappelle, L. Jaap, Sivasampu, Sheamini, and Vaartjes, Ilonca

Published
2017

295. Trends in comorbidity in patients hospitalised for cardiovascular disease

Author

UMC Utrecht, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Interne Geneeskunde Vasculaire, Buddeke, Josefien, Bots, Michiel L., van Dis, Ineke, Liem, Anho H, Visseren, Frank L.J., Vaartjes, Ilonca, UMC Utrecht, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Interne Geneeskunde Vasculaire, Buddeke, Josefien, Bots, Michiel L., van Dis, Ineke, Liem, Anho H, Visseren, Frank L.J., and Vaartjes, Ilonca

Published
2017

296. Chance of surgery in adult congenital heart disease

Author

UMC Utrecht, Cardiovasculaire Immunologie, Cardiovasculaire Epi Team 4, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Hubrecht Institute with UMC, Cardiologie patientenzorg, Cardiovasculaire Epi Team 9, Verheugt, Carianne L., Uiterwaal, Cuno S.P.M., Vaartjes, Ilonca, Van Der Velde, Enno T., Zomer, A. C., Meijboom, Folkert J., Pieper, Petronella G, Post, Marco C., Vliegen, Hubert W, Hazekamp, Mark G., Grobbee, Diederick E., Mulder, Barbara J M, UMC Utrecht, Cardiovasculaire Immunologie, Cardiovasculaire Epi Team 4, Circulatory Health, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Hubrecht Institute with UMC, Cardiologie patientenzorg, Cardiovasculaire Epi Team 9, Verheugt, Carianne L., Uiterwaal, Cuno S.P.M., Vaartjes, Ilonca, Van Der Velde, Enno T., Zomer, A. C., Meijboom, Folkert J., Pieper, Petronella G, Post, Marco C., Vliegen, Hubert W, Hazekamp, Mark G., Grobbee, Diederick E., and Mulder, Barbara J M

Published
2017

297. Long-term exposure to particulate matter, NO2 and the oxidative potential of particulates and diabetes prevalence in a large national health survey

Author

UMC Utrecht, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Strak, Maciej, Veldhorst-Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, Hoek, Gerard, UMC Utrecht, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Infectieziekten Team 3, Infection & Immunity, JC onderzoeksprogramma Infectieziekten, Strak, Maciej, Veldhorst-Janssen, Nicole, Beelen, Rob, Schmitz, Oliver, Vaartjes, Ilonca, Karssenberg, Derek, van den Brink, Carolien, Bots, Michiel L., Dijst, Martin, Brunekreef, Bert, and Hoek, Gerard

Published
2017

298. Quality assurance and the need to evaluate interventions and audit programme outcomes

Author

Global Health, Circulatory Health, Global Health team 1, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, Zhao, Min, Vaartjes, Ilonca, Klipstein-Grobusch, Kerstin, Kotseva, Kornelia, Jennings, Catriona, Grobbee, Diederick E, Graham, Ian, Global Health, Circulatory Health, Global Health team 1, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 9, Zhao, Min, Vaartjes, Ilonca, Klipstein-Grobusch, Kerstin, Kotseva, Kornelia, Jennings, Catriona, Grobbee, Diederick E, and Graham, Ian

Published
2017

299. Prevalence of cardiovascular medication on secondary prevention after myocardial infarction in China between 1995-2015: A systematic review and meta-analysis

Author

Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Cardiovasculaire Epi Team 9, Cardiovasculaire Epi Team 5, Zhao, M, Klipstein-Grobusch, Kerstin, Wang, Xin, Reitsma, Johannes B, Zhao, Dong, Grobbee, Diederick E, Graham, Ian, Vaartjes, Ilonca, Global Health, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Epi Methoden Team 4, JC onderzoeksprogramma Methodologie, Cardiovasculaire Epi Team 9, Cardiovasculaire Epi Team 5, Zhao, M, Klipstein-Grobusch, Kerstin, Wang, Xin, Reitsma, Johannes B, Zhao, Dong, Grobbee, Diederick E, Graham, Ian, and Vaartjes, Ilonca

Published
2017

300. Ethnic Variations in Prognosis of Patients with Dementia:A Prospective Nationwide Registry Linkage Study in The Netherlands

Author

Agyemang, Charles, van de Vorst, Irene E., Koek, Huiberdina L., Bots, Michiel L., Sexas, Azizi, Norredam, Marie, Ikram, Umar, Stronks, Karien, Vaartjes, Ilonca, Agyemang, Charles, van de Vorst, Irene E., Koek, Huiberdina L., Bots, Michiel L., Sexas, Azizi, Norredam, Marie, Ikram, Umar, Stronks, Karien, and Vaartjes, Ilonca

Abstract

BACKGROUND: Data on dementia prognosis among ethnic minority groups are limited in Europe.OBJECTIVE: We assessed differences in short-term (1-year) and long-term (3-year) mortality and readmission risk after a first hospitalization or first ever referral to a day clinic for dementia between ethnic minority groups and the ethnic Dutch population in the NetherlandsMethods: Nationwide prospective cohorts of first hospitalized dementia patients (N = 55,827) from January 1, 2000 to December 31, 2010 were constructed. Differences in short-term and long-term mortality and readmission risk following hospitalization or referral to the day clinic between ethnic minority groups (Surinamese, Turkish, Antilleans, Indonesians) and the ethnic Dutch population were investigated using Cox proportional hazard regression models with adjustment for age, sex, and comorbidities.RESULTS: Age-sex-adjusted short-term and long-term risks of death following a first hospitalization with dementia were comparable between the ethnic minority groups and the ethnic Dutch. Age- and sex-adjusted risk of admission was higher only in Turkish compared with ethnic Dutch (HR 1.57, 95% CI,1.08-2.29). The difference between Turkish and the Dutch attenuated and was no longer statistically significant after further adjustment for comorbidities. There were no ethnic differences in short-term and long-term risk of death, and risk of readmission among day clinic patients.CONCLUSION: Compared with Dutch patients with a comparable comorbidity rate, ethnic minority patients with dementia did not have a worse prognosis. Given the poor prognosis of dementia, timely and targeted advance care planning is essential, particularly in ethnic minority groups who are mired by cultural barriers and where uptake of advance care planning is known to be low.

Published
2017

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