Search

Your search keyword '"Stehouwer, Coen"' showing total 4,509 results
Start Over Author "Stehouwer, Coen"
4,509 results on '"Stehouwer, Coen"'

251. Cognitive resilience depends on white matter connectivity: The Maastricht Study

Author

DeJong, Nathan R., primary, Jansen, Jacobus F.A., additional, van Boxtel, Martin P.J., additional, Schram, Miranda T., additional, Stehouwer, Coen D.A., additional, Dagnelie, Pieter C., additional, van der Kallen, Carla J.H., additional, Kroon, Abraham A., additional, Wesselius, Anke, additional, Koster, Annemarie, additional, Backes, Walter H., additional, and Köhler, Sebastian, additional

Published
2022
Full Text
View/download PDF

252. Intrahepatic lipid content is independently associated with soluble E-selectin levels: The Maastricht study

Author

Brouwers, Martijn C.G.J., primary, Simons, Nynke, additional, Kooi, Marianne Eline, additional, de Ritter, Rianneke, additional, van Dongen, Martien C.J.M., additional, Eussen, Simone J.P.M., additional, Bekers, Otto, additional, Kooman, Jeroen, additional, van Greevenbroek, Marleen M.J., additional, van der Kallen, Carla J.H., additional, Schram, Miranda T., additional, Schaper, Nicolaas C., additional, Schalkwijk, Casper G., additional, and Stehouwer, Coen D.A., additional

Published
2022
Full Text
View/download PDF

255. Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults: A Systematic Review of the Health Council of the Netherlands

Author

Hengeveld, Linda M, primary, de Goede, Janette, additional, Afman, Lydia A, additional, Bakker, Stephan J L, additional, Beulens, Joline W J, additional, Blaak, Ellen E, additional, Boersma, Eric, additional, Geleijnse, Johanna M, additional, van Goudoever, Johannes (Hans) B, additional, Hopman, Maria T E, additional, Iestra, Jolein A, additional, Kremers, Stef P J, additional, Mensink, Ronald P, additional, de Roos, Nicole M, additional, Stehouwer, Coen D A, additional, Verkaik-Kloosterman, Janneke, additional, de Vet, Emely, additional, and Visser, Marjolein, additional

Published
2022
Full Text
View/download PDF

257. Association Between Diabetic Retinopathy, Brain Structural Abnormalities, and Cognitive Impairment for Accumulated Evidence in Observational Studies

Author

Chai, Yin-He, primary, Zhang, Yong-Peng, additional, Qiao, Yu-Shun, additional, Gong, Hong-Jian, additional, Xu, Hui, additional, She, Hai-Cheng, additional, Patel, Ikramulhaq, additional, Liu, Wei, additional, Stehouwer, Coen D.A., additional, Zhou, Jian-Bo, additional, and Simó, Rafael, additional

Published
2022
Full Text
View/download PDF

258. Reply

Author

Ren, Zhewen, primary, Simons, Pomme I. H. G., additional, Wesselius, Anke, additional, Stehouwer, Coen D. A., additional, and Brouwers, Martijn C. G. J., additional

Published
2022
Full Text
View/download PDF

259. NEURODEGENERATION, MICROVASCULAR DYSFUNCTION AND THEIR INTERACTION: ASSOCIATIONS WITH COGNITIVE PERFORMANCE – THE MAASTRICHT STUDY

Author

Heide, Frank van der, primary, Henry, Ronald, additional, Houben, Alfons, additional, Kroon, Abraham, additional, Kallen, Carla van der, additional, Dagnelie, Pieter, additional, Schram, Miranda, additional, Eussen, Simone, additional, Berendschot, Tos, additional, Schouten, Jan, additional, Webers, Carroll, additional, Greevenbroek, Marleen Van, additional, Wesselius, Anke, additional, Koster, Annemarie, additional, Savelberg, Hans, additional, Schaper, Nicolaas, additional, Schalkwijk, Casper, additional, Boxtel, Martin van, additional, Kohler, Seb, additional, and Stehouwer, Coen, additional

Published
2022
Full Text
View/download PDF

261. ALCOHOL CONSUMPTION AND MICROVASCULAR DYSFUNCTION: A J-SHAPED ASSOCIATION– THE MAASTRICHT STUDY

Author

Heide, Frank van der, primary, Eussen, Simone, additional, Houben, Alfons, additional, Henry, Ronald, additional, Kroon, Abraham, additional, Kallen, Carla van der, additional, Dagnelie, Pieter, additional, Dongen, Martien Van, additional, Berendschot, Tos, additional, Schouten, Jan, additional, Webers, Carroll, additional, Schram, Miranda, additional, Greevenbroek, Marleen Van, additional, Wesselius, Anke, additional, Schalkwijk, Casper, additional, Koster, Annemarie, additional, Jansen, Jacobus, additional, Backes, Walter, additional, Beulens, Joline, additional, and Stehouwer, Coen, additional

Published
2022
Full Text
View/download PDF

266. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and risk of depression among older people with hypertension

Author

van Sloten, Thomas T, Souverein, Patrick C, Stehouwer, Coen DA, Driessen, Johanna Hm, Afd Pharmacoepi & Clinical Pharmacology, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, Afd Pharmacoepi & Clinical Pharmacology, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), MUMC+: MA Reumatologie (9), Clinical Pharmacy, and RS: NUTRIM - R3 - Respiratory & Age-related Health

Subjects
Male, SYMPTOMS, hypertension, pharmacoepidemiology, BLOCKADE, Angiotensin-Converting Enzyme Inhibitors, Thiazides, Angiotensin Receptor Antagonists, DOUBLE-BLIND, SMALL VESSEL DISEASE, INFLAMMATION, IMPROVES, Humans, Pharmacology (medical), cardiovascular diseases, NITRIC-OXIDE SYNTHASE, Diuretics, Aged, ASSOCIATIONS, Pharmacology, Depression, BRAIN MICROVESSELS, Psychiatry and Mental health, antihypertensive drugs, MOOD, Female
Abstract

Background: Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), commonly used antihypertensive drugs, may have a protective effect against depression in older individuals, but evidence in humans is limited. Aims: We evaluated the risk of depression, among older individuals with hypertension, comparing ACE or ARB initiators to thiazide(-like) diuretic initiators. Thiazide(-like) diuretics were used as control because these drugs are not associated with mood disorders. Methods: We used a propensity score-matched new user cohort design with routinely collected data from general practices in England from the Clinical Practice Research Datalink database. We matched 12,938 pairs of new users of ACEIs/ARBs and thiazide(-like) diuretics with hypertension (mean age 67.6 years; 54.7% women). Follow-up time started on the date of drug initiation and ended on the date of treatment discontinuation plus 30 days, or switch to a comparator, occurrence of a study event, death, date of patient’s transfer out of practice, or end of the study period. The primary outcome was a composite endpoint of treated depression and nonfatal and fatal self-harm. Results/outcomes: Compared to the thiazide(-like) diuretic group, ACEIs/ARBs use was not associated with a lower risk of the primary outcome (hazard ratio 0.96 (95% confidence interval: 0.79; 1.15)). Results did not differ according to lipophilicity, duration of use, and average daily dose, or class (ACEIs or ARBs). Conclusions/Interpretation: New use of ACEIs or ARBs is not associated with a lower risk of depression among individuals with hypertension.

Published
2022

267. Relationship between NAFLD and coronary artery disease: A Mendelian randomization study

Author

Ren, Zhewen, Simons, Pomme I H G, Wesselius, Anke, Stehouwer, Coen D A, Brouwers, Martijn C G J, Interne Geneeskunde, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome, Epidemiologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, MUMC+: HVC Pieken Maastricht Studie (9), MUMC+: MA Interne Geneeskunde (3), MUMC+: Centrum voor Chronische Zieken (3), MUMC+: MA Med Staf Artsass Interne Geneeskunde (9), MUMC+: MA Endocrinologie (9), MUMC+: MA Maag Darm Lever (9), MUMC+: MA Hematologie (9), MUMC+: MA Medische Oncologie (9), MUMC+: MA Nefrologie (9), and MUMC+: MA Reumatologie (9)

Subjects
RISK, Hepatology, CARDIOVASCULAR-DISEASE, EXOME-WIDE ASSOCIATION, MORTALITY, INHIBITION, EPIDEMIOLOGY, ISCHEMIC-HEART-DISEASE, CONFERS SUSCEPTIBILITY, METAANALYSIS, FATTY LIVER-DISEASE
Abstract

BACKGROUND & AIMS: There is an ongoing debate on whether non-alcoholic fatty liver disease (NAFLD) is an active contributor or an innocent bystander in the pathogenesis of coronary artery disease (CAD). The aim of the present study was to assess the causal relationship between NAFLD and CAD.APPROACH & RESULTS: We performed two-sample Mendelian randomization (MR) analyses using summary-level data to assess the association between genetically predicted NAFLD (i.e. chronically-elevated serum alanine aminotransferase levels [cALT], imaging-based and biopsy-confirmed NAFLD) and risk of CAD. Analyses were repeated after exclusion of NAFLD susceptibility genes that are associated with impaired VLDL secretion. Inverse-variance weighted (IVW) MR analyses showed a statistically significant association between genetically predicted cALT and risk of CAD (odds ratio [OR]:1.116, 95% confidence interval [CI]:1.039,1.199), but not for the other NAFLD-related traits (OR:1.046, 95%CI:0.764,1.433 and OR:1.014, 95%CI:0.968,1.062 for imaging-based and biopsy-confirmed NAFLD, respectively). MR Egger regression revealed a statistically significant intercept, indicative of directional pleiotropy, for all traits. Repeat analyses after exclusion of genes associated with impaired VLDL secretion, showed consistent associations between genetically predicted NAFLD and CAD for all traits, i.e. cALT (OR:1.203, 95%CI:1.113,1.300), imaging-based (OR:2.149, 95%CI:1.276,3.620) and biopsy-confirmed NAFLD (OR:1.113, 95%CI:1.041,1.189), which persisted when more stringent biopsy-confirmed NAFLD criteria were used (OR:1.154, 95%CI:1.043,1.278) or when more stringent MR methods were applied. MR Egger regression did not show a statistically significant intercept.CONCLUSION: The two-sample MR analyses showed a robust association between genetically predicted NAFLD and CAD after exclusion of genetic variants that are implicated in impaired VLDL secretion.

Published
2022

268. Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour

Author

Mills, Melinda C., Tropf, Felix C., Brazel, David M., van Zuydam, Natalie, Vaez, Ahmad, Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexis, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johannes, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Markus, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthias, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Markus, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashis, Scholz, Markus, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Joris, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Akimova, Evelina T., Bergmann, Sven, Boardman, Jason D., Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey-Smith, George, Davies, Gail, Deary, Ian J., Franco, Oscar, Gaskins, Audrey J., de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Grabe, Hans Jörgen, Gunderson, Erica P., Harris, Kathleen Mullan, Hartwig, Fernando P., He, Chunyan, Hill, W. David, Homuth, Georg, Horta, Bernando Lessa, Huang, Hongyang, Hyppӧnen, Elina, Ikram, M. Arfan, Johannesson, Magnus, Kamali, Zoha, Kavousi, Maryam, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, McQueen, Matthew B., Medland, Sarah E., Meitinger, Thomas, Metspalu, Andres, Mihailov, Evelin, Missmer, Stacey A., Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Peters, Annette, Power, Chris, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Stefánsson, Kári, Stöckl, Doris, Strauch, Konstantin, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Pers, Tune H., Snieder, Harold, Perry, John R. B., Ong, Ken K., den Hoed, Marcel, Barban, Nicola, Day, Felix R., Mills, M. C., Tropf, F. C., Brazel, D. M., van Zuydam, N., Vaez, A., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Battle, A., Beutner, F., Jan Bonder, M., Boomsma, D. I., Christiansen, M. W., Claringbould, A., Deelen, P., Esko, T., Fave, M. -J., Franke, L., Frayling, T., Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kahonen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg, J., Kukushkina, V., Kutalik, Z., Lee, B., Lehtimaki, T., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Montgomery, G. W., Muller-Nurasyid, M., Nauck, M., Nivard, M. G., Penninx, B. W. J. H., Perola, M., Pervjakova, N., Pierce, B. L., Powell, J., Prokisch, H., Psaty, B. M., Raitakari, O. T., Ripatti, S., Rotzschke, O., Rueger, S., Saha, A., Scholz, M., Schramm, K., Seppala, I., Slagboom, E. P., Stehouwer, C. D. A., Stumvoll, M., Sullivan, P., 't Hoen, P. A. C., Teumer, A., Thiery, J., Tong, L., Tonjes, A., van Dongen, J., van Iterson, M., van Meurs, J., Veldink, J. H., Verlouw, J., Visscher, P. M., Volker, U., Vosa, U., Westra, H. -J., Wijmenga, C., Yaghootkar, H., Yang, J., Zeng, B., Zhang, F., van Greevenbroek, M. M. J., Schalkwijk, C. G., Deelen, J., van Heemst, D., van Duijn, C. M., Hofman, B. A., Isaacs, A., Uitterlinden, A. G., Verbiest, M., Suchiman, H. E. D., Verkerk, M., van der Breggen, R., van Rooij, J., Lakenberg, N., Bot, J., Zhernakova, D. V., Luijk, R., Bonder, M. J., Swertz, M. A., van Zwet, E. W., Akimova, E. T., Bergmann, S., Boardman, J. D., Buring, J. E., Cesarini, D., Chasman, D. I., Chavarro, J. E., Cocca, M., Concas, M. P., Davey-Smith, G., Davies, G., Deary, I. J., Gaskins, A. J., de Geus, E. J. C., Gieger, C., Girotto, G., Grabe, H. J., Gunderson, E. P., Harris, K. M., Hartwig, F. P., He, C., Homuth, G., Horta, B. L., Jan Hottenga, J., Huang, H., Hyppӧnen, E., Ikram, M. A., Johannesson, M., Kamali, Z., Kavousi, M., Kraft, P., Kuhnel, B., Langenberg, C., Study, L. C., Lind, P. A., Luan, J., Magi, R., Magnusson, P. K. E., Mahajan, A., Martin, N. G., Mbarek, H., Mccarthy, M. I., Mcmahon, G., Mcqueen, M. B., Medland, S. E., Meitinger, T., Metspalu, A., Mihailov, E., Missmer, S. A., Mollegaard, S., Mook-Kanamori, D. O., Morgan, A., van der Most, P. J., de Mutsert, R., Noordam, R., Power, C., Redmond, P., Rich-Edwards, J. W., Ridker, P. M., Rietveld, C. A., Ring, S. M., Rose, L. M., Rueedi, R., Stefansson, K., Stockl, D., Strauch, K., Thurik, A. R., Timpson, N. J., Turman, C., Wareham, N. J., Willemsen, G., Zhao, J. H., Pers, T. H., Snieder, H., Perry, J. R. B., Ong, K. K., den Hoed, M., Barban, N., Day, F. R., Mills, Melinda C, Tropf, Felix C, Brazel, David M, van Zuydam, Natalie, Vaez, Ahmad, Pers, Tune H, Snieder, Harold, Perry, John RB, Ong, Ken K, den Hoed, Marcel, Barban, Nicola, Day, Felix R, Hyppӧnen, Elina, eQTLGen Consortium, BIOS Consortium, Human Reproductive Behaviour Consortium, Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health, Consortium, eQTLGen, Consortium, BIOS, Consortium, Human Reproductive Behaviour, Mahajan, A, McCarthy, MI, Mills, Melinda C., Tropf, Felix C., Brazel, David M., Agbessi, Mawussé, Ahsan, Habibul, Alves, Isabel, Andiappan, Anand Kumar, Arindrarto, Wibowo, Awadalla, Philip, Battle, Alexi, Beutner, Frank, Jan Bonder, Marc, Boomsma, Dorret I., Christiansen, Mark W., Claringbould, Annique, Deelen, Patrick, Esko, Tõnu, Favé, Marie-Julie, Franke, Lude, Frayling, Timothy, Gharib, Sina A., Gibson, Greg, Heijmans, Bastiaan T., Hemani, Gibran, Jansen, Rick, Kähönen, Mika, Kalnapenkis, Anette, Kasela, Silva, Kettunen, Johanne, Kim, Yungil, Kirsten, Holger, Kovacs, Peter, Krohn, Knut, Kronberg, Jaanika, Kukushkina, Viktorija, Kutalik, Zoltan, Lee, Bernett, Lehtimäki, Terho, Loeffler, Marku, Marigorta, Urko M., Mei, Hailang, Milani, Lili, Montgomery, Grant W., Müller-Nurasyid, Martina, Nauck, Matthia, Nivard, Michel G., Penninx, Brenda W. J. H., Perola, Marku, Pervjakova, Natalia, Pierce, Brandon L., Powell, Joseph, Prokisch, Holger, Psaty, Bruce M., Raitakari, Olli T., Ripatti, Samuli, Rotzschke, Olaf, Rüeger, Sina, Saha, Ashi, Scholz, Marku, Schramm, Katharina, Seppälä, Ilkka, Slagboom, Eline P., Stehouwer, Coen D. A., Stumvoll, Michael, Sullivan, Patrick, ‘t Hoen, Peter A. C., Teumer, Alexander, Thiery, Joachim, Tong, Lin, Tönjes, Anke, van Dongen, Jenny, van Iterson, Maarten, van Meurs, Joyce, Veldink, Jan H., Verlouw, Joost, Visscher, Peter M., Völker, Uwe, Võsa, Urmo, Westra, Harm-Jan, Wijmenga, Cisca, Yaghootkar, Hanieh, Yang, Jian, Zeng, Biao, Zhang, Futao, Isaacs, Aaron, Pool, René, Jan Hottenga, Jouke, van Greevenbroek, Marleen M. J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Zhernakova, Sasha, Tigchelaar, Ettje F., Beekman, Marian, Deelen, Jori, van Heemst, Diana, van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Bert A., Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Galen, Michiel, Bot, Jan, Zhernakova, Dasha V., van ’t Hof, Peter, Nooren, Irene, Moed, Matthij, Vermaat, Martijn, Luijk, René, van Dijk, Freerk, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik. W., Akimova, Evelina T., Bergmann, Sven, Boardman, Jason D., Brumat, Marco, Buring, Julie E., Cesarini, David, Chasman, Daniel I., Chavarro, Jorge E., Cocca, Massimiliano, Concas, Maria Pina, Davey-Smith, George, Davies, Gail, Deary, Ian J., Franco, Oscar, Gaskins, Audrey J., de Geus, Eco J. C., Gieger, Christian, Girotto, Giorgia, Grabe, Hans Jörgen, Gunderson, Erica P., Harris, Kathleen Mullan, Hartwig, Fernando P., He, Chunyan, Hill, W. David, Homuth, Georg, Horta, Bernando Lessa, Huang, Hongyang, Ikram, M. Arfan, Johannesson, Magnu, Kamali, Zoha, Kavousi, Maryam, Kraft, Peter, Kühnel, Brigitte, Langenberg, Claudia, Lind, Penelope A., Luan, Jian’an, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Mbarek, Hamdi, McCarthy, Mark I., McMahon, George, McQueen, Matthew B., Medland, Sarah E., Meitinger, Thoma, Metspalu, Andre, Mihailov, Evelin, Missmer, Stacey A., Møllegaard, Stine, Mook-Kanamori, Dennis O., Morgan, Anna, van der Most, Peter J., de Mutsert, Renée, Nolte, Ilja M., Noordam, Raymond, Peters, Annette, Power, Chri, Redmond, Paul, Rich-Edwards, Janet W., Ridker, Paul M., Rietveld, Cornelius A., Ring, Susan M., Rose, Lynda M., Rueedi, Rico, Stefánsson, Kári, Stöckl, Dori, Strauch, Konstantin, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thurik, A. Roy, Timpson, Nicholas J., Turman, Constance, Waldenberger, Melanie, Wareham, Nicholas J., Willemsen, Gonneke, Zhao, Jing Hau, Pers, Tune H., Perry, John R. B., Ong, Ken K., Day, Felix R., Sociology [until 2010], Biological Psychology, APH - Methodology, Sociology and Social Gerontology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Management and Organisation, Urology, Medical Informatics, Department of Marketing Management, Epidemiology, Internal Medicine, Radiology & Nuclear Medicine, Neurology, Applied Economics, and Life Course Epidemiology (LCE)

Subjects
Male, demography, genetic variants, reproductive biology, externalising behavior, environmental effects, Disease, Genome-wide association studies, Behavioral Neuroscience, 0302 clinical medicine, genetics, media_common, fertility, 0303 health sciences, Reproduction, Incidence (epidemiology), Coitus, Age Factors, Longevity, sexual intercourse, health, Spermatid differentiation, Single Nucleotide, Reproduction/genetics, 3. Good health, Behavioural genetics, Parturition/genetics, Female, infertility, Infertility, genetic variant, Adolescent, Social Psychology, media_common.quotation_subject, Experimental and Cognitive Psychology, Polymorphism, Single Nucleotide, Article, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Reproductive biology, medicine, Humans, Polymorphism, behavioural genetics, first sexual intercourse, Genetic Association Studies, Demography, 030304 developmental biology, Parturition, Coitus/physiology, medicine.disease, externalising behaviour, Sexual intercourse, Fertility, age, 030217 neurology & neurosurgery, first birth
Abstract

Age at first sexual intercourse and age at first birth have implications for health and evolutionary fitness. In this genome-wide association study (age at first sexual intercourse, N = 387,338; age at first birth, N = 542,901), we identify 371 single-nucleotide polymorphisms, 11 sex-specific, with a 5–6% polygenic score prediction. Heritability of age at first birth shifted from 9% [CI = 4–14%] for women born in 1940 to 22% [CI = 19–25%] for those born in 1965. Signals are driven by the genetics of reproductive biology and externalising behaviour, with key genes related to follicle stimulating hormone (FSHB), implantation (ESR1), infertility and spermatid differentiation. Our findings suggest that polycystic ovarian syndrome may lead to later age at first birth, linking with infertility. Late age at first birth is associated with parental longevity and reduced incidence of type 2 diabetes and cardiovascular disease. Higher childhood socioeconomic circumstances and those in the highest polygenic score decile (90%+) experience markedly later reproductive onset. Results are relevant for improving teenage and late-life health, understanding longevity and guiding experimentation into mechanisms of infertility.

Published
2021

269. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and risk of depression among older people with hypertension

Author

Afd Pharmacoepi & Clinical Pharmacology, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, van Sloten, Thomas T, Souverein, Patrick C, Stehouwer, Coen DA, Driessen, Johanna Hm, Afd Pharmacoepi & Clinical Pharmacology, Sub Gen. Pharmacoepi and Clinical Pharm, Pharmacoepidemiology and Clinical Pharmacology, van Sloten, Thomas T, Souverein, Patrick C, Stehouwer, Coen DA, and Driessen, Johanna Hm

Published
2022

270. Genome-wide study of DNA methylation shows alterations in metabolic, inflammatory, and cholesterol pathways in ALS

Author

Hop, Paul J., Zwamborn, Ramona A.J., Hannon, Eilis, Shireby, Gemma L., Nabais, Marta F., Walker, Emma M., van Rheenen, Wouter, van Vugt, Joke J.F.A., Dekker, Annelot M., Westeneng, Henk-Jan, Tazelaar, Gijs H.P., van Eijk, Kristel R., Moisse, Matthieu, Baird, Denis, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Ticozzi, Nicola, Ratti, Antonia, Cooper-Knock, Jonathan, Morrison, Karen E., Shaw, Pamela J., Basak, A. Nazli, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Brunetti, Maura, Grassano, Maurizio, Gotkine, Marc, Lerner, Yossef, Zabari, Michal, Vourc'H, Patrick, Corcia, Philippe, Couratier, Philippe, Mora Pardina, Jesus S., Salas, Teresa, Dion, Patrick, Ross, Jay P., Henderson, Robert D., Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Nicholson, Garth, Rowe, Dominic B., Pamphlett, Roger, Mather, Karen A., Sachdev, Perminder S., Furlong, Sarah, Garton, Fleur C., Henders, Anjali K., Lin, Tian, Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Williams, Kelly L., Neto, Miguel Mitne, Cauchi, Ruben J., Blair, Ian P., Kiernan, Matthew C., Drory, Vivian, Povedano, Monica, de Carvalho, Mamede, Pinto, Susana, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Landers, John E., Shaw, Christopher E., Andersen, Peter M., McRae, Allan F., van Es, Michael A., Pasterkamp, R. Jeroen, Wray, Naomi R., McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Tsai, Ellen, Runz, Heiko, Al-Chalabi, Ammar, van den Berg, Leonard H., Van Damme, Philip, Mill, Jonathan, Veldink, Jan H., Heijmans, Bastiaan T., t Hoen, Peter A.C., van Meurs, Joyce, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Joukje J., van Greevenbroek, Marleen M.J., Stehouwer, Coen D.A., van der Kallen, Carla J.H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, Eka H.D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van 'T Hof, Peter, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik W., Bensimon, Gilbert, Smith, George Davey, Hop, Paul J., Zwamborn, Ramona A.J., Hannon, Eilis, Shireby, Gemma L., Nabais, Marta F., Walker, Emma M., van Rheenen, Wouter, van Vugt, Joke J.F.A., Dekker, Annelot M., Westeneng, Henk-Jan, Tazelaar, Gijs H.P., van Eijk, Kristel R., Moisse, Matthieu, Baird, Denis, Al Khleifat, Ahmad, Iacoangeli, Alfredo, Ticozzi, Nicola, Ratti, Antonia, Cooper-Knock, Jonathan, Morrison, Karen E., Shaw, Pamela J., Basak, A. Nazli, Chiò, Adriano, Calvo, Andrea, Moglia, Cristina, Canosa, Antonio, Brunetti, Maura, Grassano, Maurizio, Gotkine, Marc, Lerner, Yossef, Zabari, Michal, Vourc'H, Patrick, Corcia, Philippe, Couratier, Philippe, Mora Pardina, Jesus S., Salas, Teresa, Dion, Patrick, Ross, Jay P., Henderson, Robert D., Mathers, Susan, McCombe, Pamela A., Needham, Merrilee, Nicholson, Garth, Rowe, Dominic B., Pamphlett, Roger, Mather, Karen A., Sachdev, Perminder S., Furlong, Sarah, Garton, Fleur C., Henders, Anjali K., Lin, Tian, Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Williams, Kelly L., Neto, Miguel Mitne, Cauchi, Ruben J., Blair, Ian P., Kiernan, Matthew C., Drory, Vivian, Povedano, Monica, de Carvalho, Mamede, Pinto, Susana, Weber, Markus, Rouleau, Guy A., Silani, Vincenzo, Landers, John E., Shaw, Christopher E., Andersen, Peter M., McRae, Allan F., van Es, Michael A., Pasterkamp, R. Jeroen, Wray, Naomi R., McLaughlin, Russell L., Hardiman, Orla, Kenna, Kevin P., Tsai, Ellen, Runz, Heiko, Al-Chalabi, Ammar, van den Berg, Leonard H., Van Damme, Philip, Mill, Jonathan, Veldink, Jan H., Heijmans, Bastiaan T., t Hoen, Peter A.C., van Meurs, Joyce, Jansen, Rick, Franke, Lude, Boomsma, Dorret I., Pool, René, van Dongen, Jenny, Hottenga, Joukje J., van Greevenbroek, Marleen M.J., Stehouwer, Coen D.A., van der Kallen, Carla J.H., Schalkwijk, Casper G., Wijmenga, Cisca, Zhernakova, Sasha, Tigchelaar, Ettje F., Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, van Duijn, Cornelia M., Hofman, Bert A., Isaacs, Aaron, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, Eka H.D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, van 'T Hof, Peter, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik W., Bensimon, Gilbert, and Smith, George Davey

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with an estimated heritability between 40 and 50%. DNA methylation patterns can serve as proxies of (past) exposures and disease progression, as well as providing a potential mechanism that mediates genetic or environmental risk. Here, we present a blood-based epigenome-wide association study meta-analysis in 9706 samples passing stringent quality control (6763 patients, 2943 controls). We identified a total of 45 differentially methylated positions (DMPs) annotated to 42 genes, which are enriched for pathways and traits related to metabolism, cholesterol biosynthesis, and immunity. We then tested 39 DNA methylation-based proxies of putative ALS risk factors and found that high-density lipoprotein cholesterol, body mass index, white blood cell proportions, and alcohol intake were independently associated with ALS. Integration of these results with our latest genome-wide association study showed that cholesterol biosynthesis was potentially causally related to ALS. Last, DNA methylation at several DMPs and blood cell proportion estimates derived from DNA methylation data were associated with survival rate in patients, suggesting that they might represent indicators of underlying disease processes potentially amenable to therapeutic interventions.

Published
2022
Full Text
View/download PDF

271. Anxiety and cognitive functioning in the Maastricht study: A cross-sectional population study

Author

Gulpers, Bernice J. A., Verhey, Frans R. J., Eussen, Simone J. P. M., Schram, M.T., Galan, B.E. de, Boxtel, Martin P. J. van, Stehouwer, Coen D. A., Kohler, S., Gulpers, Bernice J. A., Verhey, Frans R. J., Eussen, Simone J. P. M., Schram, M.T., Galan, B.E. de, Boxtel, Martin P. J. van, Stehouwer, Coen D. A., and Kohler, S.

Abstract

Contains fulltext : 283878.pdf (Publisher’s version ) (Open Access)

Published
2022

273. The cardiometabolic depression subtype and its association with clinical characteristics: The Maastricht Study

Author

Geraets, Anouk, Schram, Miranda, Jansen, Jacobus, Backes, Walter, Schalkwijk, Casper, Stehouwer, Coen, van Boxtel, Martin, Eussen, Simone, Kooman, Jeroen, Verhey, Frans, Köhler, Sebastian, Geraets, Anouk, Schram, Miranda, Jansen, Jacobus, Backes, Walter, Schalkwijk, Casper, Stehouwer, Coen, van Boxtel, Martin, Eussen, Simone, Kooman, Jeroen, Verhey, Frans, and Köhler, Sebastian

Published
2022

274. Plasma metabolomic profiling of dietary patterns associated with glucose metabolism status: The Maastricht Study

Author

Sub Algorithmic Data Analysis, Sub Pharmacotherapy, Theoretical, Algorithmic Data Analysis, Yu, Evan Yi Wen, Ren, Zhewen, Mehrkanoon, Siamak, Stehouwer, Coen D.A., van Greevenbroek, Marleen M.J., Eussen, Simone J.P.M., Zeegers, Maurice P., Wesselius, Anke, Sub Algorithmic Data Analysis, Sub Pharmacotherapy, Theoretical, Algorithmic Data Analysis, Yu, Evan Yi Wen, Ren, Zhewen, Mehrkanoon, Siamak, Stehouwer, Coen D.A., van Greevenbroek, Marleen M.J., Eussen, Simone J.P.M., Zeegers, Maurice P., and Wesselius, Anke

Published
2022

275. Fructose Intake From Fruit Juice and Sugar-Sweetened Beverages Is Associated With Higher Intrahepatic Lipid Content: The Maastricht Study

Author

Buziau, Amée M, Eussen, Simone J P M, Kooi, M Eline, van der Kallen, Carla J H, van Dongen, Martien C J M, Schaper, Nicolaas C, Henry, Ronald M A, Schram, Miranda T, Dagnelie, Pieter C, van Greevenbroek, Marleen M J, Wesselius, Anke, Bekers, Otto, Meex, Steven J R, Schalkwijk, Casper G, Stehouwer, Coen D A, Brouwers, Martijn C G J, Buziau, Amée M, Eussen, Simone J P M, Kooi, M Eline, van der Kallen, Carla J H, van Dongen, Martien C J M, Schaper, Nicolaas C, Henry, Ronald M A, Schram, Miranda T, Dagnelie, Pieter C, van Greevenbroek, Marleen M J, Wesselius, Anke, Bekers, Otto, Meex, Steven J R, Schalkwijk, Casper G, Stehouwer, Coen D A, and Brouwers, Martijn C G J

Abstract

OBJECTIVE: Epidemiological evidence regarding the relationship between fructose intake and intrahepatic lipid (IHL) content is inconclusive. We, therefore, assessed the relationship between different sources of fructose and IHL at the population level.RESEARCH DESIGN AND METHODS: We used cross-sectional data from The Maastricht Study, with a population-based cohort (n = 3,981; mean ± SD age: 60 ± 9 years; 50% women). We assessed the relationship between fructose intake (assessed with a food-frequency questionnaire)-total and derived from fruit, fruit juice, and sugar-sweetened beverages (SSB)-and IHL (quantified with 3T Dixon MRI) with adjustment for age, sex, type 2 diabetes, education, smoking status, physical activity, and intakes of total energy, alcohol, saturated fat, protein, vitamin E, and dietary fiber.RESULTS: Energy-adjusted total fructose intake and energy-adjusted fructose from fruit were not associated with IHL in the fully adjusted models (P = 0.647 and P = 0.767). In contrast, energy-adjusted intake of fructose from fruit juice and SSB was associated with higher IHL in the fully adjusted models (P = 0.019 and P = 0.009). Individuals in the highest tertile of energy-adjusted intake of fructose from fruit juice and SSB had a 1.04-fold (95% CI 0.99; 1.11) and 1.09-fold (95% CI 1.03; 1.16) higher IHL, respectively, in comparison with the lowest tertile in the fully adjusted models. Finally, the association for fructose from fruit juice was stronger in individuals with type 2 diabetes (P for interaction = 0.071).CONCLUSIONS: Fructose from fruit juice and SSB is independently associated with higher IHL. These cross-sectional findings contribute to current knowledge in support of measures to reduce the intake of fructose-containing beverages as a means to prevent nonalcoholic fatty liver disease at the population level.

Published
2022

276. Role of Weekday Variation on Glucose, Insulin, and Triglyceride:A Cross-Sectional Analysis From the Maastricht Study

Author

Clemmensen, Kim K. B., Koster, Annemarie, Nielen, Johannes T. H., Dagnelie, Pieter C., Stehouwer, Coen D. A., Bosma, Hans, Wesselius, Anke, Færch, Kristine, Eussen, Simone J. P. M., Clemmensen, Kim K. B., Koster, Annemarie, Nielen, Johannes T. H., Dagnelie, Pieter C., Stehouwer, Coen D. A., Bosma, Hans, Wesselius, Anke, Færch, Kristine, and Eussen, Simone J. P. M.

Abstract

Context: The timing of sleep, physical activity, and dietary intake show variation over the week, with different timings in the weekend compared to the weekdays, which may potentially lead to impaired glucose and lipid regulation on Mondays compared to other weekdays.Objective The aim of the study was to investigate differences in glucose metabolism and fasting triglyceride concentrations on Mondays compared to the rest of the week.Design, setting and participants This cross-sectional study is based on data from the Maastricht Study, including 6067 participants without known diabetes and 1568 previously diagnosed with type 2 diabetes.Main outcome measures Confounder-adjusted linear regression analysis was applied to study the associations of day of the week of examination with glucose and insulin responses to an oral glucose tolerance test and fasting triglyceride concentrations.Results In fully confounder-adjusted models, mean (95% CI) concentrations of fasting glucose, insulin, and triglycerides were slightly higher on Mondays compared with the other weekdays [glucose: 1% (0-2); insulin: 9% (1-18); triglycerides: 5% (2-8)]. Interaction analyses revealed that the association of weekday with insulin was only pronounced in men [18% (3-35)], but not in women [1% (-8-10)], whereas the associations with glucose and triglycerides were only apparent for individuals with known type 2 diabetes [glucose: 4% (0-7); triglycerides: 14% (6-23)] compared to the background population [glucose: 0% (0-1); triglycerides: 3% (0-6)].Discussion Being examined on a Monday was associated with higher fasting insulin concentrations among men but not women.

Published
2022

277. Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults:A Systematic Review of the Health Council of the Netherlands

Author

Hengeveld, Linda M., de Goede, Janette, Afman, Lydia A., Bakker, Stephan J.L., Beulens, Joline W.J., Blaak, Ellen E., Boersma, Eric, Geleijnse, Johanna M., van Goudoever, Johannes Hans B., Hopman, Maria T.E., Iestra, Jolein A., Kremers, Stef P.J., Mensink, Ronald P., de Roos, Nicole M., Stehouwer, Coen D.A., Verkaik-Kloosterman, Janneke, de Vet, Emely, Visser, Marjolein, Hengeveld, Linda M., de Goede, Janette, Afman, Lydia A., Bakker, Stephan J.L., Beulens, Joline W.J., Blaak, Ellen E., Boersma, Eric, Geleijnse, Johanna M., van Goudoever, Johannes Hans B., Hopman, Maria T.E., Iestra, Jolein A., Kremers, Stef P.J., Mensink, Ronald P., de Roos, Nicole M., Stehouwer, Coen D.A., Verkaik-Kloosterman, Janneke, de Vet, Emely, and Visser, Marjolein

Abstract

Whether older adults need more protein than younger adults is debated. The population reference intake for adults set by the European Food Safety Authority is 0.83 g/kg body weight (BW)/d based primarily on nitrogen balance studies, but the underlying data on health outcomes are outdated. An expert committee of the Health Council of the Netherlands conducted a systematic review (SR) of randomized controlled trials (RCTs) examining the effect of increased protein intake on health outcomes in older adults from the general population with an average habitual protein intake ≥0.8 g/(kg BW · d). Exposures were the following: 1) extra protein compared with no protein and 2) extra protein and physical exercise compared with physical exercise. Outcomes included lean body mass, muscle strength, physical performance, bone health, blood pressure, serum glucose and insulin, serum lipids, kidney function, and cognition. Data of >1300 subjects from 18 RCTs were used. Risk of bias was judged as high (n = 9) or "some concerns" (n = 9). In 7 of 18 RCTs, increased protein intake beneficially affected ≥1 of the tested outcome measures of lean body mass. For muscle strength, this applied to 3 of 8 RCTs in the context of physical exercise and in 1 of 7 RCTs without physical exercise. For the other outcomes, <30% (0-29%) of RCTs showed a statistically significant effect. The committee concluded that increased protein intake has a possible beneficial effect on lean body mass and, when combined with physical exercise, muscle strength; likely no effect on muscle strength when not combined with physical exercise, or on physical performance and bone health; an ambiguous effect on serum lipids; and that too few RCTs were available to allow for conclusions on the other outcomes. This SR provides insufficiently convincing data that increasing protein in older adults with a protein intake ≥0.8 g/(kg BW · d) elicits health benefits.

Published
2022

278. A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals : The deAGEing Trial

Author

Linkens, Armand M.A., van Best, Niels, Niessen, Petra M., Wijckmans, Nicole E.G., de Goei, Erica E.C., Scheijen, Jean L.J.M., van Dongen, Martien C.J.M., van Gool, Christel C.J.A.W., de Vos, Willem M., Houben, Alfons J.H.M., Stehouwer, Coen D.A., Eussen, Simone J.M.P., Penders, John, Schalkwijk, Casper G., Linkens, Armand M.A., van Best, Niels, Niessen, Petra M., Wijckmans, Nicole E.G., de Goei, Erica E.C., Scheijen, Jean L.J.M., van Dongen, Martien C.J.M., van Gool, Christel C.J.A.W., de Vos, Willem M., Houben, Alfons J.H.M., Stehouwer, Coen D.A., Eussen, Simone J.M.P., Penders, John, and Schalkwijk, Casper G.

Abstract

Dietary advanced glycation endproducts (AGEs), abundantly present in Westernized diets, are linked to negative health outcomes, but their impact on the gut microbiota has not yet been well investigated in humans. We investigated the effects of a 4-week isocaloric and macronutrient-matched diet low or high in AGEs on the gut microbial composition of 70 abdominally obese individuals in a double-blind parallel-design randomized controlled trial (NCT03866343). Additionally, we investigated the cross-sectional associations between the habitual intake of dietary dicarbonyls, reactive precursors to AGEs, and the gut microbial composition, as assessed by 16S rRNA amplicon-based sequencing. Despite a marked percentage difference in AGE intake, we observed no differences in microbial richness and the general community structure. Only the Anaerostipes spp. had a relative abundance >0.5% and showed differential abundance (0.5 versus 1.11%; p = 0.028, after low-or high-AGE diet, respectively). While the habitual intake of dicarbonyls was not associated with microbial richness or a general community structure, the intake of 3-deoxyglucosone was especially associated with an abundance of several genera. Thus, a 4-week diet low or high in AGEs has a limited impact on the gut microbial composition of abdominally obese humans, paralleling its previously observed limited biological consequences. The effects of dietary dicarbonyls on the gut microbiota composition deserve further investigation.

Published
2022

279. Health Effects of Increasing Protein Intake Above the Current Population Reference Intake in Older Adults: A Systematic Review of the Health Council of the Netherlands

Author

Hengeveld, Linda M., de Goede, Janette, Afman, Lydia A., Bakker, Stephan J.L., Beulens, Joline W.J., Blaak, Ellen E., Boersma, Eric, Geleijnse, Johanna M., Van Goudoever, Johannes B., Hopman, Maria T.E., Iestra, Jolein A., Kremers, Stef P.J., Mensink, Ronald P., De Roos, Nicole M., Stehouwer, Coen D.A., Verkaik-Kloosterman, Janneke, de Vet, Emely, Visser, Marjolein, Hengeveld, Linda M., de Goede, Janette, Afman, Lydia A., Bakker, Stephan J.L., Beulens, Joline W.J., Blaak, Ellen E., Boersma, Eric, Geleijnse, Johanna M., Van Goudoever, Johannes B., Hopman, Maria T.E., Iestra, Jolein A., Kremers, Stef P.J., Mensink, Ronald P., De Roos, Nicole M., Stehouwer, Coen D.A., Verkaik-Kloosterman, Janneke, de Vet, Emely, and Visser, Marjolein

Abstract

Whether older adults need more protein than younger adults is debated. The population reference intake for adults set by the European Food Safety Authority is 0.83 g/kg body weight (BW)/d based primarily on nitrogen balance studies, but the underlying data on health outcomes are outdated. An expert committee of the Health Council of the Netherlands conducted a systematic review (SR) of randomized controlled trials (RCTs) examining the effect of increased protein intake on health outcomes in older adults from the general population with an average habitual protein intake ≥0.8 g/(kg BW · d). Exposures were the following: 1) extra protein compared with no protein and 2) extra protein and physical exercise compared with physical exercise. Outcomes included lean body mass, muscle strength, physical performance, bone health, blood pressure, serum glucose and insulin, serum lipids, kidney function, and cognition. Data of >1300 subjects from 18 RCTs were used. Risk of bias was judged as high (n = 9) or “some concerns” (n = 9). In 7 of 18 RCTs, increased protein intake beneficially affected ≥1 of the tested outcome measures of lean body mass. For muscle strength, this applied to 3 of 8 RCTs in the context of physical exercise and in 1 of 7 RCTs without physical exercise. For the other outcomes, <30% (0–29%) of RCTs showed a statistically significant effect. The committee concluded that increased protein intake has a possible beneficial effect on lean body mass and, when combined with physical exercise, muscle strength; likely no effect on muscle strength when not combined with physical exercise, or on physical performance and bone health; an ambiguous effect on serum lipids; and that too few RCTs were available to allow for conclusions on the other outcomes. This SR provides insufficiently convincing data that increasing protein in older adults with a protein intake ≥0.8 g/(kg BW · d) elicits health benefits.

Published
2022

280. Causal relationship between polycystic ovary syndrome and coronary artery disease: A Mendelian randomisation study

Author

Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Simons, Pomme I H G, Cornelissen, Merel E.B., Valkenburg, Olivier, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Stehouwer, Coen D A, Burgess, Stephen, Brouwers, Martijn C G J, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Cardiovasculaire Epi Team 1, Simons, Pomme I H G, Cornelissen, Merel E.B., Valkenburg, Olivier, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Stehouwer, Coen D A, Burgess, Stephen, and Brouwers, Martijn C G J

Published
2022

283. Replacement Effects of Sedentary Time on Metabolic Outcomes: The Maastricht Study

Author

VAN DER BERG, JULIANNE D., VAN DER VELDE, JEROEN H. P. M., DE WAARD, ELLIS A. C., BOSMA, HANS, SAVELBERG, HANS H. C. M., SCHAPER, NICOLAAS C., VAN DEN BERGH, JOOP P. W., GEUSENS, PIET P. M. M., SCHRAM, MIRANDA T., SEP, SIMONE J. S., VAN DER KALLEN, CARLA J. H., HENRY, RONALD M. A., DAGNELIE, PIETER C., EUSSEN, SIMONE J. P. M., VAN DONGEN, MARTIEN C. J. M., KÖHLER, SEBASTIAN, KROON, ABRAHAM A., STEHOUWER, COEN D. A., and KOSTER, ANNEMARIE

Published
2017
Full Text
View/download PDF

288. Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose.

Author

Xiaodi Zhang, Scheijen, Jean L. J. M., Stehouwer, Coen D. A., Wouters, Kristiaan, and Schalkwijk, Casper G.

Subjects
GLUCOSE tolerance tests, BLOOD sugar, PYRUVALDEHYDE, SERUM albumin, GLUCOSE
Abstract

The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycation endproducts (AGEs). MGO and AGEs are increased in subjects with diabetes and are associated with fatal and nonfatal cardiovascular disease. Previously, we have shown that plasma MGO concentrations rapidly increase in the postprandial phase, with a higher increase in individuals with type 2 diabetes. In current study, we investigated whether postprandial MGO formation in plasma and tissues originates from exogenous glucose and whether the increased plasma MGO concentration leads to a fast formation of MGO-derived AGEs. We performed a stable isotope-labelled oral glucose tolerance test (OGTT) in 12 healthy males with universally labelled D(+)13C glucose. Analysis of plasma-labelled 13C3 MGO and glucose levels at 11 time-points during the OGTT revealed that the newly formed MGO during OGTT is completely derived from exogenous glucose. Moreover, a fast formation of protein-bound MGO-derived AGEs during the OGTT was observed. In accordance, ex-vivo incubation of MGO with plasma or albumin showed a rapid decrease in MGO and a fast increase in MGO-derived AGEs. In an intraperitoneal glucose tolerance test in C57BL/6J mice, we confirmed that the formation of postprandial MGO is derived from exogenous glucose in plasma and also showed in tissues that MGO is increased and this is also from exogenous glucose. Collectively, increased formation of MGO during a glucose tolerance test arises from exogenous glucose both in plasma and in tissues, and this leads to a fast formation of MGO-derived AGEs. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

289. Cognitive resilience depends on white matter connectivity: The Maastricht Study.

Author

DeJong, Nathan R., Jansen, Jacobus F.A., van Boxtel, Martin P.J., Schram, Miranda T., Stehouwer, Coen D.A., Dagnelie, Pieter C., van der Kallen, Carla J.H., Kroon, Abraham A., Wesselius, Anke, Koster, Annemarie, Backes, Walter H., and Köhler, Sebastian

Abstract

Introduction: Differences in brain network connectivity may reflect the capability of the neurological substrate to compensate for brain damage and preserve cognitive function (cognitive reserve). We examined the associations between white matter connectivity, brain damage markers, and cognition in a population sample of middle‐aged individuals. Methods: A total of 4759 participants from The Maastricht Study (mean age = 59.2, SD = 8.7, 50.2% male) underwent cognitive testing and diffusion magnetic resonance imaging (dMRI), from which brain volume, structural connectivity, and vascular damage were quantified. Multivariable linear regression was used to investigate whether connectivity modified the association between brain damage and cognition, adjusted for demographic and cardiometabolic risk factors. Results: More atrophic and vascular brain damage was associated with worse cognition scores. Increasing connectivity moderated the negative association between damage and cognition (χ2 = 8.64, df = 3, p ≤ 0.001); individuals with high damage but strong connectivity showed normal cognition. Discussion: Findings support the reserve hypothesis by showing that brain connectivity is associated with cognitive resilience. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

290. Alcohol consumption and microvascular dysfunction: a J-shaped association: The Maastricht Study.

Author

van der Heide, Frank C. T., Eussen, Simone J. P. M., Houben, Alfons J. H. M., Henry, Ronald M. A., Kroon, Abraham A., van der Kallen, Carla J. H., Dagnelie, Pieter C., van Dongen, Martien C. J. M., Berendschot, Tos T. J. M., Schouten, Jan S. A. G., Webers, Carroll A. B., van Greevenbroek, Marleen M. J., Wesselius, Anke, Schalkwijk, Casper G., Koster, Annemarie, Jansen, Jacobus F. A., Backes, Walter H., Beulens, Joline W. J., and Stehouwer, Coen D. A.

Subjects
MICROCIRCULATION disorders, CEREBRAL small vessel diseases, CARDIOVASCULAR diseases, CHRONIC kidney failure, DIABETIC retinopathy
Abstract

Background: Microvascular dysfunction (MVD) is an important contributor to major clinical disease such as stroke, dementia, depression, retinopathy, and chronic kidney disease. Alcohol consumption may be a determinant of MVD. Objective: Main objectives were (1) to study whether alcohol consumption was associated with MVD as assessed in the brain, retina, skin, kidney and in the blood; and (2) to investigate whether associations differed by history of cardiovascular disease or sex. Design: We used cross-sectional data from The Maastricht Study (N = 3,120 participants, 50.9% men, mean age 60 years, and 27.5% with type 2 diabetes [the latter oversampled by design]). We used regression analyses to study the association between total alcohol (per unit and in the categories, i.e. none, light, moderate, high) and MVD, where all measures of MVD were combined into a total MVD composite score (expressed in SD). We adjusted all associations for potential confounders; and tested for interaction by sex, and history of cardiovascular disease. Additionally we tested for interaction with glucose metabolism status. Results: The association between total alcohol consumption and MVD was non-linear, i.e. J-shaped. Moderate versus light total alcohol consumption was significantly associated with less MVD, after full adjustment (beta [95% confidence interval], -0.10 [-0.19; -0.01]). The shape of the curve differed with sex (Pinteraction = 0.03), history of cardiovascular disease (Pinteraction < 0.001), and glucose metabolism status (Pinteraction = 0.02). Conclusions: The present cross-sectional, population-based study found evidence that alcohol consumption may have an effect on MVD. Hence, although increasing alcohol consumption cannot be recommended as a policy, this study suggests that prevention of MVD may be possible through dietary interventions. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

291. Associations between plasma sulfur amino acids and specific fat depots in two independent cohorts: CODAM and The Maastricht Study.

Author

Tore, Elena C., Elshorbagy, Amany K., Bakers, Frans C. H., Brouwers, Martijn C. G. J., Dagnelie, Pieter C., Eussen, Simone J. P. M., Jansen, Jacobus F. A., Kooi, M. Eline, Kusters, Yvo H. A. M., Meex, Steven J. R., Olsen, Thomas, Refsum, Helga, Retterstøl, Kjetil, Schalkwijk, Casper G., Stehouwer, Coen D. A., Vinknes, Kathrine J., and van Greevenbroek, Marleen M. J.

Subjects
OBESITY risk factors, OBESITY complications, SULFUR amino acids, BODY composition, CYSTEINE, HOMOCYSTEINE, GLUTATHIONE, SKINFOLD thickness, PHOTON absorptiometry, CONFIDENCE intervals, CROSS-sectional method, LIQUID chromatography, ABDOMINAL adipose tissue, REGRESSION analysis, METHIONINE, NON-alcoholic fatty liver disease, METABOLIC disorders, RISK assessment, DESCRIPTIVE statistics, MASS spectrometry, RESEARCH funding, WAIST circumference, BODY mass index, LOGISTIC regression analysis, ODDS ratio, ADIPOSE tissues, LONGITUDINAL method, PREDIABETIC state, DISEASE risk factors
Abstract

Purpose: Sulfur amino acids (SAAs) have been associated with obesity and obesity-related metabolic diseases. We investigated whether plasma SAAs (methionine, total cysteine (tCys), total homocysteine, cystathionine and total glutathione) are related to specific fat depots. Methods: We examined cross-sectional subsets from the CODAM cohort (n = 470, 61.3% men, median [IQR]: 67 [61, 71] years) and The Maastricht Study (DMS; n = 371, 53.4% men, 63 [55, 68] years), enriched with (pre)diabetic individuals. SAAs were measured in fasting EDTA plasma with LC–MS/MS. Outcomes comprised BMI, skinfolds, waist circumference (WC), dual-energy X-ray absorptiometry (DXA, DMS), body composition, abdominal subcutaneous and visceral adipose tissues (CODAM: ultrasound, DMS: MRI) and liver fat (estimated, in CODAM, or MRI-derived, in DMS, liver fat percentage and fatty liver disease). Associations were examined with linear or logistic regressions adjusted for relevant confounders with z-standardized primary exposures and outcomes. Results: Methionine was associated with all measures of liver fat, e.g., fatty liver disease [CODAM: OR = 1.49 (95% CI 1.19, 1.88); DMS: OR = 1.51 (1.09, 2.14)], but not with other fat depots. tCys was associated with overall obesity, e.g., BMI [CODAM: β = 0.19 (0.09, 0.28); DMS: β = 0.24 (0.14, 0.34)]; peripheral adiposity, e.g., biceps and triceps skinfolds [CODAM: β = 0.15 (0.08, 0.23); DMS: β = 0.20 (0.12, 0.29)]; and central adiposity, e.g., WC [CODAM: β = 0.16 (0.08, 0.25); DMS: β = 0.17 (0.08, 0.27)]. Associations of tCys with VAT and liver fat were inconsistent. Other SAAs were not associated with body fat. Conclusion: Plasma concentrations of methionine and tCys showed distinct associations with different fat depots, with similar strengths in the two cohorts. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

292. Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial

Author

Soedamah-Muthu, Sabita S., Livingstone, Shona J., Charlton-Menys, Valentine, Betteridge, D. John, Hitman, Graham A., Neil, H. Andrew W., Bao, Weihang, DeMicco, David A., Preston, Gregory M., Fuller, John H., Stehouwer, Coen D. A., Schalkwijk, Casper G., Durrington, Paul N., Colhoun, Helen M., and on behalf of the CARDS Investigators

Published
2015
Full Text
View/download PDF

297. Genetically proxied ketohexokinase function and risk of colorectal cancer: a Mendelian randomisation study

Author

Buziau, Amée M, primary, Law, Philip J, additional, Blokland, Gabriella, additional, Schalkwijk, Casper, additional, Scheijen, Jean, additional, Simons, Pomme, additional, van der Kallen, Carla, additional, Eussen, Simone, additional, Dagnelie, Pieter C, additional, van Greevenbroek, Marleen, additional, Houlston, Richard S, additional, Wesselius, Anke, additional, Went, Molly, additional, Stehouwer, Coen, additional, and Brouwers, Martijn CGJ, additional

Published
2022
Full Text
View/download PDF

298. A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial

Author

Linkens, Armand M. A., primary, van Best, Niels, additional, Niessen, Petra M., additional, Wijckmans, Nicole E. G., additional, de Goei, Erica E. C., additional, Scheijen, Jean L. J. M., additional, van Dongen, Martien C. J. M., additional, van Gool, Christel C. J. A. W., additional, de Vos, Willem M., additional, Houben, Alfons J. H. M., additional, Stehouwer, Coen D. A., additional, Eussen, Simone J. M. P., additional, Penders, John, additional, and Schalkwijk, Casper G., additional

Published
2022
Full Text
View/download PDF

299. Health burden in type 2 diabetes and prediabetes in The Maastricht Study

Author

Veugen, Marja G. J., primary, Onete, Veronica G., additional, Henry, Ronald M. A., additional, Brunner-La Rocca, Hans-Peter, additional, Koster, Annemarie, additional, Dagnelie, Pieter C., additional, Schaper, Nicolaas C., additional, Sep, Simone J. S., additional, van der Kallen, Carla J. H., additional, van Boxtel, Martin P. J., additional, Reesink, Koen D., additional, Schouten, Johannes S., additional, Savelberg, Hans H. C. M., additional, Köhler, Sebastian, additional, Verhey, Frans R., additional, van den Bergh, Joop P. W., additional, Schram, Miranda T., additional, and Stehouwer, Coen D. A., additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results