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3,982 results on '"Shin, In‐Sik"'

251. Supplementary Figure 4 from Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity

Author

Jo, Jae-Cheol, primary, Choi, Eun Kyoung, primary, Shin, Jae-Sik, primary, Moon, Jai-Hee, primary, Hong, Seung-Woo, primary, Lee, Ha-Reum, primary, Kim, Seung-Mi, primary, Jung, Soo-A, primary, Lee, Dae-Hee, primary, Jung, Seang Hwan, primary, Lee, Sun-Hye, primary, Kim, Jeong Eun, primary, Kim, Kyu-pyo, primary, Hong, Yong Sang, primary, Suh, Young-Ah, primary, Jang, Se Jin, primary, Choi, Eun Kyung, primary, Lee, Jung Shin, primary, Jin, Dong-Hoon, primary, and Kim, Tae Won, primary

Published
2023
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252. Data from Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity

Author

Jo, Jae-Cheol, primary, Choi, Eun Kyoung, primary, Shin, Jae-Sik, primary, Moon, Jai-Hee, primary, Hong, Seung-Woo, primary, Lee, Ha-Reum, primary, Kim, Seung-Mi, primary, Jung, Soo-A, primary, Lee, Dae-Hee, primary, Jung, Seang Hwan, primary, Lee, Sun-Hye, primary, Kim, Jeong Eun, primary, Kim, Kyu-pyo, primary, Hong, Yong Sang, primary, Suh, Young-Ah, primary, Jang, Se Jin, primary, Choi, Eun Kyung, primary, Lee, Jung Shin, primary, Jin, Dong-Hoon, primary, and Kim, Tae Won, primary

Published
2023
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253. Supplementary Figure 2 from Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity

Author

Jo, Jae-Cheol, primary, Choi, Eun Kyoung, primary, Shin, Jae-Sik, primary, Moon, Jai-Hee, primary, Hong, Seung-Woo, primary, Lee, Ha-Reum, primary, Kim, Seung-Mi, primary, Jung, Soo-A, primary, Lee, Dae-Hee, primary, Jung, Seang Hwan, primary, Lee, Sun-Hye, primary, Kim, Jeong Eun, primary, Kim, Kyu-pyo, primary, Hong, Yong Sang, primary, Suh, Young-Ah, primary, Jang, Se Jin, primary, Choi, Eun Kyung, primary, Lee, Jung Shin, primary, Jin, Dong-Hoon, primary, and Kim, Tae Won, primary

Published
2023
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255. Supplementary Figure legend from Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity

Author

Jo, Jae-Cheol, primary, Choi, Eun Kyoung, primary, Shin, Jae-Sik, primary, Moon, Jai-Hee, primary, Hong, Seung-Woo, primary, Lee, Ha-Reum, primary, Kim, Seung-Mi, primary, Jung, Soo-A, primary, Lee, Dae-Hee, primary, Jung, Seang Hwan, primary, Lee, Sun-Hye, primary, Kim, Jeong Eun, primary, Kim, Kyu-pyo, primary, Hong, Yong Sang, primary, Suh, Young-Ah, primary, Jang, Se Jin, primary, Choi, Eun Kyung, primary, Lee, Jung Shin, primary, Jin, Dong-Hoon, primary, and Kim, Tae Won, primary

Published
2023
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256. Supplementary Table 1 from Targeting FGFR Pathway in Human Hepatocellular Carcinoma: Expressing pFGFR and pMET for Antitumor Activity

Author

Jo, Jae-Cheol, primary, Choi, Eun Kyoung, primary, Shin, Jae-Sik, primary, Moon, Jai-Hee, primary, Hong, Seung-Woo, primary, Lee, Ha-Reum, primary, Kim, Seung-Mi, primary, Jung, Soo-A, primary, Lee, Dae-Hee, primary, Jung, Seang Hwan, primary, Lee, Sun-Hye, primary, Kim, Jeong Eun, primary, Kim, Kyu-pyo, primary, Hong, Yong Sang, primary, Suh, Young-Ah, primary, Jang, Se Jin, primary, Choi, Eun Kyung, primary, Lee, Jung Shin, primary, Jin, Dong-Hoon, primary, and Kim, Tae Won, primary

Published
2023
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267. Political economy of protectionism in EC-Korea trade

Author

Shin, Koo-Sik

Subjects
382, International commerce & international trade
Abstract

This thesis examines from an international political economy(IPE) perspective the determinants and the effectiveness of the EC's protective measures against Korean exports to the EC market. Both the determinants and the effectiveness of protective measures, in countries which adopt such restraints, have been very controversial issues in the academic world. Through broad and industry-specific case analyses, I found that approaches regarding determinants of protectionism in the IPE literature are not fully applicable as determinants of EC protectionism against Korea and I extracted several determinants which are more relevant to the issue of EC-Korea trade protectionism. These are primarily divided between economic and political determinants. The economic determinants include 1)a causal relationship between protectionism by the United States against Korea and protectionism by the EC against Korea, 2)Korea's neo-mercantilist policy approach and concentration of exports on a limited range of products, and 3)inter-industry trade structure between the EC and Korea, such as growing trade disputes in specific sectors. The political determinants, I found, are l)political expediency of the EC's protectionism against Korea, which can be seen in examples of EC's policy implementation procedures, such as low rate of actual imposition of the EC's import restraints, and the use of anti-dumping investigations as a preliminary gambit in order to obtain concessions, and 2)a form of " Japan Complex" effective against Korean exports to the EC. In addition to the above determinants, there are some specific determinants(or specific procedures and incidents) in connection with individual industries--the EC's inconsistent policy implementation and the clerical errors due to the growing workload of the EC Commission(textiles and clothing case), businesscycle(iron and steel case), the EC's retaliation against closed markets abroad, and the successful experience of Italy and France in restricting imports of Korean footwear through VER5 (footwear case), and EC's built-in protectionism and failure in demand forecast, and the deep-rooted distrust of Korean CTV exporters by the EC(CTV case). In order to analyse the effectiveness of protective measures, I began by examining approaches by David Yoffie and Patrick Messerlin. For the test of these approaches, I examined the effectiveness of EC's import restraints against Korean products by comparing how Korea's exports of those products changed, in terms of volume and value, following EC action. My findings are that the EC's protective measures were successful in all cases excepting one: the footwear products from Korea, the imports of which continued to increase during the 1987- 1991 period despite EC restraints. I found that the major determinant of effectiveness of EC's VERS was Korea's international competitiveness in terms of revealed comparative advantage (RCA) ratio of the subjected products. Specifically, Korea's strong competitiveness(and some weakening of EC's competitiveness) in footwear contributed to the continued increase in shipments of Korea's footwear to the EC market. In contrast, EC's VERs against iron and steel products, in which the EC has maintained international competitive strength, were very effective in reversing growth of imports from Korea. Additionally, EC's impositions of AD duties proved to be very effective as a means of protecting EC industries against foreign threat; all Korean products subject to EC's AD measures showed a declining trend in exports to the EC market during the 1987-1991 period, regardless of any weakness or strength in international competitiveness of subjected products. I concluded that the ineffectiveness of import restraints, suggested by David Yoffie for U.S.-NIE5 trade, does not apply to EC-Korea trade. Patrick Messerlin's approach, however, is applicable in the ECKorea trade. I also found that arguments which only link job losses in the EC with foreign imports are flawed. EC companies face job losses not only as a direct result of Korean imports, but also from the inability of EC industry to restructure, and the remedial action taken by them to counter Korean competition--such as reorganization and rationalization of EC companies, offshore processing activities in cheap labour cost countries for major labour-intensive processes, and automation of production facilities.

Published
1994

268. eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining

Author

Lapointe, Christopher P., Grosely, Rosslyn, Sokabe, Masaaki, Alvarado, Carlos, Wang, Jinfan, Montabana, Elizabeth, Villa, Nancy, Shin, Byung-Sik, Dever, Thomas E., Fraser, Christopher S., Fernández, Israel S., and Puglisi, Joseph D.

Abstract

Translation initiation defines the identity and quantity of a synthesized protein. The process is dysregulated in many human diseases1,2. A key commitment step is when the ribosomal subunits join at a translation start site on a messenger RNA to form a functional ribosome. Here, we combined single-molecule spectroscopy and structural methods using an in vitro reconstituted system to examine how the human ribosomal subunits join. Single-molecule fluorescence revealed when the universally conserved eukaryotic initiation factors eIF1A and eIF5B associate with and depart from initiation complexes. Guided by single-molecule dynamics, we visualized initiation complexes that contained both eIF1A and eIF5B using single-particle cryo-electron microscopy. The resulting structure revealed how eukaryote-specific contacts between the two proteins remodel the initiation complex to orient the initiator aminoacyl-tRNA in a conformation compatible with ribosomal subunit joining. Collectively, our findings provide a quantitative and architectural framework for the molecular choreography orchestrated by eIF1A and eIF5B during translation initiation in humans.

Published
2024
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272. Clinical implications of changes in metabolic syndrome status after kidney transplantation: a nationwide prospective cohort study.

Author

Lee, Yu Ho, Song, Sang Heon, Song, Seung Hwan, Shin, Ho Sik, Yang, Jaeseok, Kim, Myoung Soo, Hwang, Hyeon Seok, and Group, the KOTRY Study

Subjects
KIDNEY transplantation, METABOLIC syndrome, CHRONIC kidney failure, COHORT analysis, CARDIOVASCULAR disease related mortality
Abstract

Background Metabolic syndrome (MetS) is prevalent in patients with end-stage kidney disease, and kidney transplantation is expected to modify the metabolic status. However, whether changes in metabolic status at the time of transplantation affect recipient outcomes remains unclear. Methods We analyzed 4187 recipients registered in a nationwide prospective cohort from 2014 to 2020. MetS was defined as the presence of three or more components of the metabolic syndrome. Patients were classified based on the pre- and post-transplant MetS status: MetS-free, MetS-developed, MetS-recovered and MetS-persistent. Study outcomes were occurrence of death-censored graft loss and a composite of cardiovascular events and death. Results Among recipients without pre-transplant MetS, 19.6% (419/2135) developed post-transplant MetS, and MetS disappeared in 38.7% (794/2052) of the recipients with pre-transplant MetS. Among the four groups, the MetS-developed group showed the worst graft survival rate, and the MetS-persistent group had a poorer composite event-free survival rate. Compared with the MetS-free group, the MetS-developed group was associated with an increased risk of graft loss [adjusted hazard ratio (aHR) 2.35; 95% confidence interval (CI) 1.17–4.98] and the risk of graft loss increased with increasing numbers of dysfunctional MetS components. MetS-persistent was associated with increased risks of cardiovascular events and death (aHR 2.46; 95% CI 1.12–5.63), but changes in the number of dysfunctional MetS components was not. Conclusion Kidney transplantation significantly alters the metabolic status. Newly developed MetS after transplantation was associated with an increased risk of graft loss, whereas persistent MetS exposure before and after transplantation was associated with increased risks cardiovascular events and patient survival. [ABSTRACT FROM AUTHOR]

Published
2023
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274. Supplementary Figure 2 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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275. Supplementary Figure 4 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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276. Supplementary Figure 3 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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277. Supplementary Figure 6 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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278. Supplementary Figure 5 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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279. Supplementary Figure 1 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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280. Supplementary Tables 1-5 from p34SEI-1 Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34SEI-1 as a Novel Target for Anti–Breast Cancer Strategies

Author

Hong, Seung-Woo, primary, Kim, Chang-Jae, primary, Park, Won-Sang, primary, Shin, Jae-Sik, primary, Lee, Soon-Duck, primary, Ko, Seong-Gyu, primary, Jung, Sam-Il, primary, Park, In-Chul, primary, An, Sung-Kwan, primary, Lee, Won-Keun, primary, Lee, Wang-Jae, primary, Jin, Dong-Hoon, primary, and Lee, Myeong-Sok, primary

Published
2023
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294. Protective Effects of Angelica Decursiva Franchet & Savatier on Allergic Responses Through Enhancement of Nrf2 and Suppression of NF-kB/MMP-9 in Ovalbumin-Exposed Mice

Author

Lee, Se-Jin, primary, Lee, A. Yeong, additional, Pak, So-Won, additional, Kim, Woong-Il, additional, Yang, Yeo-Gin, additional, Lim, Je-Oh, additional, Chae, Sung-wook, additional, Cho, Young-Kwon, additional, Kim, Jong-Choon, additional, Moon, Byeong Cheol, additional, Seo, Yun-Soo, additional, and Shin, In-Sik, additional

Published
2023
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