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254. Characterization of Ras k 1 a novel major allergen in Indian mackerel and identification of parvalbumin as the major fish allergen in 33 Asia‐Pacific fish species

Author

Ruethers, T., primary, Raith, M., additional, Sharp, M. F., additional, Koeberl, M., additional, Stephen, J. N., additional, Nugraha, R., additional, Le, T. T. K., additional, Quirce, S., additional, Nguyen, H. X. M., additional, Kamath, S. D., additional, Mehr, S. S., additional, Campbell, D. E., additional, Bridges, C. R., additional, Taki, A. C., additional, Swoboda, I., additional, and Lopata, A. L., additional

Published
2018
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263. State of the Climate in 2016

Author

Arndt, D. S., Blunden, J., Dunn, R. J. H., Aaron-morrison, Arlene P., Abdallah, A., Ackerman, Steven A., Adler, Robert, Alfaro, Eric J., Allan, Richard P., Allan, Rob, Alvarez, Luis A., Alves, Lincoln M., Amador, Jorge A., Andreassen, L. M., Arce, Dayana, Argueez, Anthony, Arndt, Derek S., Arzhanova, N. M., Augustine, John, Awatif, E. M., Azorin-molina, Cesar, Baez, Julian, Bardin, M. U., Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Beck, H. E., Becker, Andreas, Bedka, Kristopher M., Behrenfeld, Michael J., Bell, Gerald D., Belmont, M., Benedetti, Angela, Bernhard, G. H., Berrisford, Paul, Berry, David I., Bettolli, Maria L., Bhatt, U. S., Bidegain, Mario, Biskaborn, B., Bissolli, Peter, Bjerke, J., Blake, Eric S., Blunden, Jessica, Bosilovich, Michael G., Boucher, Olivier, Boudet, Dagne, Box, J. E., Boyer, Tim, Braathen, Geir O., Brimelow, Julian, Bromwich, David H., Brown, R., Buehler, S., Bulygina, Olga N., Burgess, D., Calderon, Blanca, Camargo, Suzana J., Campbell, Jayaka D., Cappelen, J., Caroff, P., Carrea, Laura, Carter, Brendan R., Chambers, Don P., Chandler, Elise, Cheng, Ming-dean, Christiansen, Hanne H., Christy, John R., Chung, Daniel, Chung, E. -s., Clem, Kyle R., Coelho, Caio A. S., Coldewey-egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Cross, J. N., Crouch, Jake, Cutie, Virgen, Davis, Sean M., De Eyto, Elvira, De Jeu, Richard A. M., De Laat, Jos, Degasperi, Curtis L., Degenstein, Doug, Demircan, M., Derksen, C., Di Girolamo, Larry, Diamond, Howard J., Dindyal, S., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolman, A. Johannes, Domingues, Catia M., Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Drozdov, D. S., Dunn, Robert J. H., Duran-quesada, Ana M., Dutton, Geoff S., Elkharrim, M., Elkins, James W., Epstein, H. E., Espinoza, Jhan C., Etienne-leblanc, Sheryl, Famiglietti, James S., Farrell, S., Fateh, S., Fausto, R. S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flannigan, Mike, Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Fonseca, C., Forbes, B. C., Foster, Michael J., Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Gerland, S., Gilson, John, Gobron, Nadine, Goldenberg, Stanley B., Goni, Gustavo, Gonzalez, Idelmis T., Goto, A., Greenhough, Marianna D., Grooss, J. -u., Gruber, Alexander, Guard, Charles, Gupta, S. K., Gutierrez, J. M., Haas, C., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hanssen-bauer, I, Hare, Jon, Harris, Ian, Heidinger, Andrew K., Heim, Richard R., Jr., Hendricks, S., Hernandez, Marieta, Hernandez, Rafael, Hidalgo, Hugo G., Ho, Shu-peng, Hobbs, William R., Huang, Boyin, Huelsing, Hannah K., Hurst, Dale F., Ialongo, I., Ijampy, J. A., Inness, Antje, Isaksen, K., Ishii, Masayoshi, Jevrejeva, Svetlana, Jimenez, C., Jin Xiangze, John, Viju, Johns, William E., Johnsen, B., Johnson, Bryan, Johnson, Gregory C., Johnson, Kenneth S., Jones, Philip D., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, J. W., Kass, David, Kato, Seiji, Kazemi, A., Kelem, G., Keller, Linda M., Kelly, B. P., Kendon, Mike, Kennedy, John, Kerr, Kenneth, Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. -j., Kimberlain, Todd B., Klotzbach, Philip J., Knaff, John A., Kochtubajda, Bob, Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Krumpen, T., Lakatos, M., Lakkala, K., Lanckmann, J. -p., Lander, Mark A., Landschuetzer, Peter, Landsea, Chris W., Lankhorst, Matthias, Lantz, Kathleen, Lazzara, Matthew A., Leuliette, Eric, Lewis, Stephen R., L'Heureux, Michelle, Lieser, Jan L., Lin, I-i, Liu, Hongxing, Liu, Yinghui, Locarnini, Ricardo, Loeb, Norman G., Long, Craig S., Loranty, M., Lorrey, Andrew M., Loyola, Diego, Lu, Mong-ming, Lumpkin, Rick, Luo, Jing-jia, Luojus, K., Lyman, John M., Macara, Gregor, Macdonald, Alison M., Macias-fauria, M., Malkova, G. V., Manney, G., Marchenko, S. S., Marengo, Jose A., Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martinez-gueingla, Rodney, Massom, Robert A., Mathis, Jeremy T., May, Linda, Mayer, Michael, Mazloff, Matthew, Mcbride, Charlotte, Mccabe, M. F., Mccarthy, Gerard, Mccarthy, M., Mcdonagh, Elaine L., Mcgree, Simon, Mcvicar, Tim R., Mears, Carl A., Meier, W., Mekonnen, A., Menezes, V. V., Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Minnis, Patrick, Miralles, Diego G., Mistelbauer, T., Mitchum, Gary T., Mitro, Srkani, Monselesan, Didier, Montzka, Stephen A., Mora, Natalie, Morice, Colin, Morrow, Blair, Mote, T., Mudryk, L., Muehle, Jens, Mullan, A. Brett, Mueller, R., Nash, Eric R., Nerem, R. Steven, Newman, Louise, Newman, Paul A., Nieto, Juan Jose, Noetzli, Jeannette, O'Neel, S., Osborn, Tim J., Overland, J., Oyunjargal, Lamjav, Parinussa, Robert M., Park, E-hyung, Pasch, Richard J., Pascual-ramirez, Reynaldo, Paterson, Andrew M., Pearce, Petra R., Pellichero, Violaine, Pelto, Mauri S., Peng, Liang, Perkins-kirkpatrick, Sarah E., Perovich, D., Petropavlovskikh, Irina, Pezza, Alexandre B., Phillips, C., Phillips, David, Phoenix, G., Pinty, Bernard, Pitts, Michael C., Pons, M. R., Porter, Avalon O., Quintana, Juan, Rahimzadeh, Fatemeh, Rajeevan, Madhavan, Rayner, Darren, Raynolds, M. K., Razuvaev, Vyacheslav N., Read, Peter, Reagan, James, Reid, Phillip, Reimer, Christoph, Remy, Samuel, Renwick, James A., Revadekar, Jayashree V., Richter-menge, J., Rimmer, Alon, Robinson, David A., Rodell, Matthew, Rollenbeck, Ruetger, Romanovsky, Vladimir E., Ronchail, Josyane, Roquet, F., Rosenlof, Karen H., Roth, Chris, Rusak, James A., Sallee, Jean-bapiste, Sanchez-lugo, Ahira, Santee, Michelle L., Sarmiento, Jorge L., Sawaengphokhai, P., Sayouri, Amal, Scambos, Ted A., Schemm, Jae, Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schoeneich, P., Schreck, Carl J., Iii, Schuur, Ted, Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Sharp, M., Shi, Lei, Shiklomanov, Nikolai I., Shimaraeva, Svetlana V., Siegel, David A., Signorini, Sergio R., Silov, Eugene, Sima, Fatou, Simmons, Adrian J., Smeed, David A., Smeets, C. J. P. P., Smith, Adam, Smith, Sharon L., Soden, B., Spence, Jaqueline M., Srivastava, A. K., Stackhouse, Paul W., Jr., Stammerjohn, Sharon, Steinbrecht, Wolfgang, Stella, Jose L., Stennett-brown, Roxann, Stephenson, Tannecia S., Strahan, Susan, Streletskiy, Dimitri A., Sun-mack, Sunny, Swart, Sebastiaan, Sweet, William, Tamar, Gerard, Taylor, Michael A., Tedesco, M., Thoman, R. L., Thompson, L., Thompson, Philip R., Timmermans, M. -l., Timofeev, Maxim A., Tirnanes, Joaquin A., Tobin, Skie, Trachte, Katja, Trewin, Blair C., Trotman, Adrian R., Tschudi, M., Tweedy, Olga, Van As, D., Van De Wal, R. S. W., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velicogna, I., Verburg, Piet, Vieira, G., Vincent, Lucie A., Voemel, Holger, Vose, Russell S., Wagner, Wolfgang, Wahlin, Anna, Walker, D. A., Walsh, J., Wang, Bin, Wang, Chunzai, Wang, Junhong, Wang, Lei, Wang, M., Wang, Sheng-hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Weller, Robert A., Weyhenmeyer, Gesa A., Whitewood, Robert, Wiese, David N., Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Willie, Shem, Willis, Josh K., Wolken, G., Wong, Takmeng, Wood, E. F., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yim, So-young, Yin, Xungang, Yu, Lisan, Zambrano, Eduardo, Zhang, Huai-min, Zhang, Peiqun, Zhao, Guanguo, Zhao, Lin, Ziemke, Jerry R., Zilberman, Nathalie, Arndt, D. S., Blunden, J., Dunn, R. J. H., Aaron-morrison, Arlene P., Abdallah, A., Ackerman, Steven A., Adler, Robert, Alfaro, Eric J., Allan, Richard P., Allan, Rob, Alvarez, Luis A., Alves, Lincoln M., Amador, Jorge A., Andreassen, L. M., Arce, Dayana, Argueez, Anthony, Arndt, Derek S., Arzhanova, N. M., Augustine, John, Awatif, E. M., Azorin-molina, Cesar, Baez, Julian, Bardin, M. U., Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Beck, H. E., Becker, Andreas, Bedka, Kristopher M., Behrenfeld, Michael J., Bell, Gerald D., Belmont, M., Benedetti, Angela, Bernhard, G. H., Berrisford, Paul, Berry, David I., Bettolli, Maria L., Bhatt, U. S., Bidegain, Mario, Biskaborn, B., Bissolli, Peter, Bjerke, J., Blake, Eric S., Blunden, Jessica, Bosilovich, Michael G., Boucher, Olivier, Boudet, Dagne, Box, J. E., Boyer, Tim, Braathen, Geir O., Brimelow, Julian, Bromwich, David H., Brown, R., Buehler, S., Bulygina, Olga N., Burgess, D., Calderon, Blanca, Camargo, Suzana J., Campbell, Jayaka D., Cappelen, J., Caroff, P., Carrea, Laura, Carter, Brendan R., Chambers, Don P., Chandler, Elise, Cheng, Ming-dean, Christiansen, Hanne H., Christy, John R., Chung, Daniel, Chung, E. -s., Clem, Kyle R., Coelho, Caio A. S., Coldewey-egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Cross, J. N., Crouch, Jake, Cutie, Virgen, Davis, Sean M., De Eyto, Elvira, De Jeu, Richard A. M., De Laat, Jos, Degasperi, Curtis L., Degenstein, Doug, Demircan, M., Derksen, C., Di Girolamo, Larry, Diamond, Howard J., Dindyal, S., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolman, A. Johannes, Domingues, Catia M., Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Drozdov, D. S., Dunn, Robert J. H., Duran-quesada, Ana M., Dutton, Geoff S., Elkharrim, M., Elkins, James W., Epstein, H. E., Espinoza, Jhan C., Etienne-leblanc, Sheryl, Famiglietti, James S., Farrell, S., Fateh, S., Fausto, R. S., Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flannigan, Mike, Flemming, Johannes, Fogt, Ryan L., Folland, Chris, Fonseca, C., Forbes, B. C., Foster, Michael J., Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Gerland, S., Gilson, John, Gobron, Nadine, Goldenberg, Stanley B., Goni, Gustavo, Gonzalez, Idelmis T., Goto, A., Greenhough, Marianna D., Grooss, J. -u., Gruber, Alexander, Guard, Charles, Gupta, S. K., Gutierrez, J. M., Haas, C., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hanssen-bauer, I, Hare, Jon, Harris, Ian, Heidinger, Andrew K., Heim, Richard R., Jr., Hendricks, S., Hernandez, Marieta, Hernandez, Rafael, Hidalgo, Hugo G., Ho, Shu-peng, Hobbs, William R., Huang, Boyin, Huelsing, Hannah K., Hurst, Dale F., Ialongo, I., Ijampy, J. A., Inness, Antje, Isaksen, K., Ishii, Masayoshi, Jevrejeva, Svetlana, Jimenez, C., Jin Xiangze, John, Viju, Johns, William E., Johnsen, B., Johnson, Bryan, Johnson, Gregory C., Johnson, Kenneth S., Jones, Philip D., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, J. W., Kass, David, Kato, Seiji, Kazemi, A., Kelem, G., Keller, Linda M., Kelly, B. P., Kendon, Mike, Kennedy, John, Kerr, Kenneth, Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. -j., Kimberlain, Todd B., Klotzbach, Philip J., Knaff, John A., Kochtubajda, Bob, Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Krumpen, T., Lakatos, M., Lakkala, K., Lanckmann, J. -p., Lander, Mark A., Landschuetzer, Peter, Landsea, Chris W., Lankhorst, Matthias, Lantz, Kathleen, Lazzara, Matthew A., Leuliette, Eric, Lewis, Stephen R., L'Heureux, Michelle, Lieser, Jan L., Lin, I-i, Liu, Hongxing, Liu, Yinghui, Locarnini, Ricardo, Loeb, Norman G., Long, Craig S., Loranty, M., Lorrey, Andrew M., Loyola, Diego, Lu, Mong-ming, Lumpkin, Rick, Luo, Jing-jia, Luojus, K., Lyman, John M., Macara, Gregor, Macdonald, Alison M., Macias-fauria, M., Malkova, G. V., Manney, G., Marchenko, S. S., Marengo, Jose A., Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martinez-gueingla, Rodney, Massom, Robert A., Mathis, Jeremy T., May, Linda, Mayer, Michael, Mazloff, Matthew, Mcbride, Charlotte, Mccabe, M. F., Mccarthy, Gerard, Mccarthy, M., Mcdonagh, Elaine L., Mcgree, Simon, Mcvicar, Tim R., Mears, Carl A., Meier, W., Mekonnen, A., Menezes, V. V., Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Minnis, Patrick, Miralles, Diego G., Mistelbauer, T., Mitchum, Gary T., Mitro, Srkani, Monselesan, Didier, Montzka, Stephen A., Mora, Natalie, Morice, Colin, Morrow, Blair, Mote, T., Mudryk, L., Muehle, Jens, Mullan, A. Brett, Mueller, R., Nash, Eric R., Nerem, R. Steven, Newman, Louise, Newman, Paul A., Nieto, Juan Jose, Noetzli, Jeannette, O'Neel, S., Osborn, Tim J., Overland, J., Oyunjargal, Lamjav, Parinussa, Robert M., Park, E-hyung, Pasch, Richard J., Pascual-ramirez, Reynaldo, Paterson, Andrew M., Pearce, Petra R., Pellichero, Violaine, Pelto, Mauri S., Peng, Liang, Perkins-kirkpatrick, Sarah E., Perovich, D., Petropavlovskikh, Irina, Pezza, Alexandre B., Phillips, C., Phillips, David, Phoenix, G., Pinty, Bernard, Pitts, Michael C., Pons, M. R., Porter, Avalon O., Quintana, Juan, Rahimzadeh, Fatemeh, Rajeevan, Madhavan, Rayner, Darren, Raynolds, M. K., Razuvaev, Vyacheslav N., Read, Peter, Reagan, James, Reid, Phillip, Reimer, Christoph, Remy, Samuel, Renwick, James A., Revadekar, Jayashree V., Richter-menge, J., Rimmer, Alon, Robinson, David A., Rodell, Matthew, Rollenbeck, Ruetger, Romanovsky, Vladimir E., Ronchail, Josyane, Roquet, F., Rosenlof, Karen H., Roth, Chris, Rusak, James A., Sallee, Jean-bapiste, Sanchez-lugo, Ahira, Santee, Michelle L., Sarmiento, Jorge L., Sawaengphokhai, P., Sayouri, Amal, Scambos, Ted A., Schemm, Jae, Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schoeneich, P., Schreck, Carl J., Iii, Schuur, Ted, Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Sharp, M., Shi, Lei, Shiklomanov, Nikolai I., Shimaraeva, Svetlana V., Siegel, David A., Signorini, Sergio R., Silov, Eugene, Sima, Fatou, Simmons, Adrian J., Smeed, David A., Smeets, C. J. P. P., Smith, Adam, Smith, Sharon L., Soden, B., Spence, Jaqueline M., Srivastava, A. K., Stackhouse, Paul W., Jr., Stammerjohn, Sharon, Steinbrecht, Wolfgang, Stella, Jose L., Stennett-brown, Roxann, Stephenson, Tannecia S., Strahan, Susan, Streletskiy, Dimitri A., Sun-mack, Sunny, Swart, Sebastiaan, Sweet, William, Tamar, Gerard, Taylor, Michael A., Tedesco, M., Thoman, R. L., Thompson, L., Thompson, Philip R., Timmermans, M. -l., Timofeev, Maxim A., Tirnanes, Joaquin A., Tobin, Skie, Trachte, Katja, Trewin, Blair C., Trotman, Adrian R., Tschudi, M., Tweedy, Olga, Van As, D., Van De Wal, R. S. W., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velicogna, I., Verburg, Piet, Vieira, G., Vincent, Lucie A., Voemel, Holger, Vose, Russell S., Wagner, Wolfgang, Wahlin, Anna, Walker, D. A., Walsh, J., Wang, Bin, Wang, Chunzai, Wang, Junhong, Wang, Lei, Wang, M., Wang, Sheng-hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Weller, Robert A., Weyhenmeyer, Gesa A., Whitewood, Robert, Wiese, David N., Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Willie, Shem, Willis, Josh K., Wolken, G., Wong, Takmeng, Wood, E. F., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yim, So-young, Yin, Xungang, Yu, Lisan, Zambrano, Eduardo, Zhang, Huai-min, Zhang, Peiqun, Zhao, Guanguo, Zhao, Lin, Ziemke, Jerry R., and Zilberman, Nathalie

Abstract

In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 +/- 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 +/- 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44 degrees C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0 degrees C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8 degrees C, representing a 3.5 degrees C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 av

Published
2017
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264. Bradycardia and hypothermia complicating azithromycin treatment.

Author

Page-Sharp M., Salman S., Benn K., Buttery J.P., Davis T.M.E., Page-Sharp M., Salman S., Benn K., Buttery J.P., and Davis T.M.E.

Abstract

Objective: Unusual or unexpected effect of treatment Background: Azithromycin is a macrolide antibiotic widely used to treat respiratory, urogenital, and other infections. Gastrointestinal upset, headache, and dizziness are common adverse effects, and prolongation of the rate-corrected electrocardiographic QT interval and malignant arrhythmias have been reported. There are rare reports of bradycardia and hypothermia but not in the same patient. Case Report: A 4-year-old boy given intravenous azithromycin as part of treatment for febrile neutropenia complicating leukemia chemotherapy developed hypothermia (rectal temperature 35.2degreeC) and bradycardia (65 beats/minute) after the second dose, which resolved over several days post-treatment, consistent with persistence of high tissue azithromycin concentrations relative to those in plasma. A sigmoid Emax pharmacokinetic/pharmacodynamic model suggested a maximal azithromycin-associated reduction in heart rate of 23 beats/minute. Monitoring for these potential adverse effects should facilitate appropriate supportive care in similar cases. Conclusion(s): Recommended azithromycin doses can cause at least moderate bradycardia and hypothermia in vulnerable pediatric patients, adverse effects that should prompt appropriate monitoring and which may take many days to resolve.Copyright © Am J Case Rep, 2017.

Published
2017

265. Bradycardia and Hypothermia Complicating Azithromycin Treatment

Author

Benn, K, Salman, S, Page-Sharp, M, Davis, TME, Buttery, JP, Benn, K, Salman, S, Page-Sharp, M, Davis, TME, and Buttery, JP

Abstract

BACKGROUND Azithromycin is a macrolide antibiotic widely used to treat respiratory, urogenital, and other infections. Gastrointestinal upset, headache, and dizziness are common adverse effects, and prolongation of the rate-corrected electrocardiographic QT interval and malignant arrhythmias have been reported. There are rare reports of bradycardia and hypothermia but not in the same patient. CASE REPORT A 4-year-old boy given intravenous azithromycin as part of treatment for febrile neutropenia complicating leukemia chemotherapy developed hypothermia (rectal temperature 35.2°C) and bradycardia (65 beats/minute) after the second dose, which resolved over several days post-treatment, consistent with persistence of high tissue azithromycin concentrations relative to those in plasma. A sigmoid Emax pharmacokinetic/pharmacodynamic model suggested a maximal azithromycin-associated reduction in heart rate of 23 beats/minute. Monitoring for these potential adverse effects should facilitate appropriate supportive care in similar cases. CONCLUSIONS Recommended azithromycin doses can cause at least moderate bradycardia and hypothermia in vulnerable pediatric patients, adverse effects that should prompt appropriate monitoring and which may take many days to resolve.

Published
2017

266. Optimal Antimalarial Dose Regimens for Sulfadoxine-Pyrimethamine with or without Azithromycin in Pregnancy Based on Population Pharmacokinetic Modeling

Author

Salman, S, Baiwog, F, Page-Sharp, M, Griffin, S, Karunajeewa, HA, Mueller, I, Rogerson, SJ, Siba, PM, Ilett, KF, Davis, TME, Salman, S, Baiwog, F, Page-Sharp, M, Griffin, S, Karunajeewa, HA, Mueller, I, Rogerson, SJ, Siba, PM, Ilett, KF, and Davis, TME

Abstract

Optimal dosing of sulfadoxine-pyrimethamine (SP) as intermittent preventive treatment in pregnancy remains to be established, particularly when coadministered with azithromycin (AZI). To further characterize SP pharmacokinetics in pregnancy, plasma concentration-time data from 45 nonpregnant and 45 pregnant women treated with SP-AZI (n = 15 in each group) and SP-chloroquine (n = 30 in each group) were analyzed. Population nonlinear mixed-effect pharmacokinetic models were developed for pyrimethamine (PYR), sulfadoxine (SDOX), and N-acetylsulfadoxine (the SDOX metabolite NASDOX), and potential covariates were included. Pregnancy increased the relative clearance (CL/F) of PYR, SDOX, and NASDOX by 48, 29, and 70%, respectively, as well as the relative volumes of distribution (V/F) of PYR (46 and 99%) and NASDOX (46%). Coadministration of AZI resulted in a greater increase in PYR CL/F (80%) and also increased NASDOX V/F by 76%. Apparent differences between these results and those of published studies of SP disposition may reflect key differences in study design, including the use of an early postpartum follow-up study rather than a nonpregnant comparator group. Simulations based on the final population model demonstrated that, compared to conventional single-dose SP in nonpregnant women, two such doses given 24 h apart should ensure that pregnant women have similar drug exposure, while three daily SP doses may be required if SP is given with AZI. The results of past and ongoing trials using recommended adult SP doses with or without AZI in pregnant women may need to be interpreted in light of these findings and consideration given to using increased doses in future trials.

Published
2017

267. Optimal antimalarial dose regimens for chloroquine in pregnancy based on population pharmacokinetic modelling

Author

Salman, S, Baiwog, F, Page-Sharp, M, Kose, K, Karunajeewa, HA, Mueller, I, Rogerson, SJ, Siba, PM, Ilett, KF, Davis, TME, Salman, S, Baiwog, F, Page-Sharp, M, Kose, K, Karunajeewa, HA, Mueller, I, Rogerson, SJ, Siba, PM, Ilett, KF, and Davis, TME

Abstract

Despite extensive use and accumulated evidence of safety, there have been few pharmacokinetic studies from which appropriate chloroquine (CQ) dosing regimens could be developed specifically for pregnant women. Such optimised CQ-based regimens, used as treatment for acute malaria or as intermittent preventive treatment in pregnancy (IPTp), may have a valuable role if parasite CQ sensitivity returns following reduced drug pressure. In this study, population pharmacokinetic/pharmacodynamic modelling was used to simultaneously analyse plasma concentration-time data for CQ and its active metabolite desethylchloroquine (DCQ) in 44 non-pregnant and 45 pregnant Papua New Guinean women treated with CQ and sulfadoxine/pyrimethamine or azithromycin (AZM). Pregnancy was associated with 16% and 49% increases in CQ and DCQ clearance, respectively, as well as a 24% reduction in CQ relative bioavailability. Clearance of DCQ was 22% lower in those who received AZM in both groups. Simulations based on the final multicompartmental model demonstrated that a 33% CQ dose increase may be suitable for acute treatment for malaria in pregnancy as it resulted in equivalent exposure to that in non-pregnant women receiving recommended doses, whilst a double dose would likely be required for an effective duration of post-treatment prophylaxis when used as IPTp especially in areas of CQ resistance. The impact of co-administered AZM was clinically insignificant in simulations. The results of past/ongoing trials employing recommended adult doses of CQ-based regimens in pregnant women should be interpreted in light of these findings, and consideration should be given to using increased doses in future trials.

Published
2017

268. Transition from hospital to home: Parents’ perception of their preparation and readiness for discharge with their preterm infant

Author

Aydon, L., Hauck, Yvonne, Murdoch, J., Siu, D., Sharp, M., Aydon, L., Hauck, Yvonne, Murdoch, J., Siu, D., and Sharp, M.

Abstract

Aims and objectives: To explore the experiences of parents with babies born between 28–32 weeks’ gestation during transition through the neonatal intensive care unit and discharge to home. Background: Following birth of a preterm baby, parents undergo a momentous journey through the neonatal intensive care unit prior to their arrival home. The complexity of the journey varies on the degree of prematurity and problems faced by each baby. The neonatal intensive care unit environment has many stressors and facilitating education to assist parents to feel ready for discharge can be challenging for all health professionals. Design: Qualitative descriptive design. Methods: The project included two phases, pre‐ and postdischarge, to capture the experiences of 20 couples (40 parents), whilst their baby was a neonatal intensive care unit inpatient and then after discharge. Face‐to‐face interviews, an online survey and telephone interviews were employed to gather parent's experiences. Constant comparative analysis was used to identify commonalities between experiences. Recruitment and data collection occurred from October 2014–February 2015. Results/Findings: Overlapping themes from both phases revealed three overarching concepts: effective parent staff communication; feeling informed and involved; and being prepared to go home. Conclusion: Our findings can be used to develop strategies to improve the neonatal intensive care unit stay and discharge experience for parents. Proposed strategies would be to improve information transfer, promote parental contact with the multidisciplinary team, encourage input from fathers to identify their needs and facilitate parental involvement according to individual needs within families. Relevance to clinical practice: Providing information to parents during their time in hospital, in a consistent and timely manner is an essential component of their preparation when transitioning to home.

Published
2017

271. State of the climate in 2015

Author

Aaron-Morrison, A.P., Ackerman, S.A., Adams, N.G., Adler, R.F., Albanil, A., Alfaro, E.J., Allan, R., Alves, L.M., Amador, J.A., Andreassen, L.M., Arendt, A., Arévalo, J., Arndt, D.S., Arzhanova, N.M., Aschan, M.M., Azorin-Molina, C., Banzon, V., Bardin, M.U., Barichivich, J., Baringer, M.O., Barreira, S., Baxter, S., Bazo, J., Becker, A., Bedka, K.M., Behrenfeld, M.J., Bell, G.D., Belmont, M., Benedetti, A., Bernhard, G., Berrisford, P., Berry, D.I., Bettolli, M.L., Bhatt, U.S., Bidegain, M., Bill, B.D., Billheimer, S., Bissolli, P., Blake, E.S., Blunden, J., Bosilovich, M.G., Boucher, O., Boudet, D., Box, J.E., Boyer, T., Braathen, G.O., Bromwich, D.H., Brown, R., Bulygina, O.N., Burgess, D., Calderón, B., Camargo, S.J., Campbell, J.D., Cappelen, J., Carrasco, G., Carter, B.R., Chambers, D.P., Chandler, E., Christiansen, H.H., Christy, J.R., Chung, D., Chung, E.-S., Cinque, K., Clem, K.R., Coelho, C.A., Cogley, J.G., Coldewey-Egbers, M., Colwell, S., Cooper, O.R., Copland, L., Cosca, C.E., Cross, J.N., Crotwell, M.J., Crouch, J., Davis, S.M., De Eyto, E., De Jeu, R.A.M., De Laat, J., Degasperi, C.L., Degenstein, D., Demircan, M., Derksen, C., Destin, D., Di Girolamo, L., Di Giuseppe, F., Diamond, H.J., Dlugokencky, E.J., Dohan, K., Dokulil, M.T., Dolgov, A.V., Dolman, A.J., Domingues, C.M., Donat, M.G., Dong, S., Dorigo, W.A., Dortch, Q., Doucette, G., Drozdov, D.S., Ducklow, H., Dunn, R.J.H., Durán-Quesada, A.M., Dutton, G.S., Ebrahim, A., Elkharrim, M., Elkins, J.W., Espinoza, J.C., Etienne-Leblanc, S., Evans, T.E., Famiglietti, J.S., Farrell, S., Fateh, S., Fausto, R.S., Fedaeff, N., Feely, R.A., Feng, Z., Fenimore, C., Fettweis, X., Fioletov, V.E., Flemming, J., Fogarty, C.T., Fogt, R.L., Folland, C., Fonseca, C., Fossheim, M., Foster, M.J., Fountain, A., Francis, S.D., Franz, B.A., Frey, R.A., Frith, S.M., Froidevaux, L., Ganter, C., Garzoli, S., Gerland, S., Gobron, N., Goldenberg, S.B., Gomez, R.S., Goni, G., Goto, A., Grooß, J.-U., Gruber, A., Guard, C.C., Gugliemin, M., Gupta, Somil, Gutiérrez, J.M., Hagos, S., Hahn, S., Haimberger, L., Hakkarainen, J., Hall, B.D., Halpert, M.S., Hamlington, B.D., Hanna, E., Hansen, K., Hanssen-Bauer, I., Harris, I., Heidinger, A.K., Heikkilä, A., Heil, A., Heim, R.R., Hendricks, S., Hernández, M., Hidalgo, H.G., Hilburn, K., Ho, S.-P.B., Holmes, R.M., Hu, Z.-Z., Huang, B., Huelsing, H.K., Huffman, G.J., Hughes, C., Hurst, D.F., Ialongo, I., Ijampy, J.A., Ingvaldsen, R.B., Inness, A., Isaksen, K., Ishii, M., Jevrejeva, S., Jiménez, C., Jin, X., Johannesen, E., John, V., Johnsen, B., Johnson, B., Johnson, G.C., Jones, P.D., Joseph, A.C., Jumaux, G., Kabidi, K., Kaiser, J.W., Kato, S., Kazemi, A., Keller, L.M., Kendon, M., Kennedy, J., Kerr, K., Kholodov, A.L., Khoshkam, M., Killick, R., Kim, H., Kim, S.-J., Kimberlain, T.B., Klotzbach, P.J., Knaff, J.A., Kobayashi, S., Kohler, J., Korhonen, J., Korshunova, N.N., Kovacs, K.M., Kramarova, N., Kratz, D.P., Kruger, A., Kruk, M.C., Kudela, R., Kumar, A., Lakatos, M., Lakkala, K., Lander, M.A., Landsea, C.W., Lankhorst, M., Lantz, K., Lazzara, M.A., Lemons, P., Leuliette, E., L’Heureux, M., Lieser, J.L., Lin, I.-I., Liu, H., Liu, Y., Locarnini, R., Loeb, N.G., Lo Monaco, C., Long, C.S., López Álvarez, L.A., Lorrey, A.M., Loyola, D., Lumpkin, R., Luo, J.-J., Luojus, K., Lydersen, C., Lyman, J.M., Maberly, S.C., Maddux, B.C., Malheiros Ramos, A., Malkova, G.V., Manney, G., Marcellin, V., Marchenko, S.S., Marengo, J.A., Marra, J.J., Marszelewski, W., Martens, B., Martínez-Güingla, R., Massom, R.A., Mata, M.M., Mathis, J.T., May, L., Mayer, M., Mazloff, M., McBride, C., McCabe, M.F., McCarthy, M., McClelland, J.W., McGree, S., McVicar, T.R., Mears, C.A., Meier, W., Meinen, C.S., Mekonnen, A., Menéndez, M., Mengistu Tsidu, G., Menzel, W.P., Merchant, C.J., Meredith, M.P., Merrifield, M.A., Metzl, N., Minnis, P., Miralles, D.G., Mistelbauer, T., Mitchum, G.T., Monselesan, D., Monteiro, P., Montzka, S.A., Morice, C., Mote, T., Mudryk, L., Mühle, J., Mullan, A.B., Nash, E.R., Naveira-Garabato, A.C., Nerem, R.S., Newman, P.A., Nieto, J.J., Noetzli, J., O’Neel, S., Osborn, T.J., Overland, J., Oyunjargal, L., Parinussa, R.M., Park, E.-H., Parker, D., Parrington, M., Parsons, A.R., Pasch, R.J., Pascual-Ramírez, R., Paterson, A.M., Paulik, C., Pearce, P.R., Pelto, M.S., Peng, L., Perkins-Kirkpatrick, S.E., Perovich, D., Petropavlovskikh, I., Pezza, A.B., Phillips, D., Pinty, B., Pitts, M.C., Pons, M.R., Porter, A.O., Primicerio, R., Proshutinsky, A., Quegan, S., Quintana, J., Rahimzadeh, F., Rajeevan, M., Randriamarolaza, L., Razuvaev, V.N., Reagan, J., Reid, P., Reimer, C., Rémy, S., Renwick, J.A., Revadekar, J.V., Richter-Menge, J., Riffler, M., Rimmer, A., Rintoul, S., Robinson, D.A., Rodell, M., Rodríguez Solís, J.L., Romanovsky, V.E., Ronchail, J., Rosenlof, K.H., Roth, C., Rusak, J.A., Sabine, C.L., Sallée, J.-B., Sánchez-Lugo, A., Santee, M.L., Sawaengphokhai, P., Sayouri, A., Scambos, T.A., Schemm, J., Schladow, S.G., Schmid, C., Schmid, M., Schmidtko, S., Schreck, C.J., Selkirk, H.B., Send, U., Sensoy, S., Setzer, A., Sharp, M., Shaw, A., Shi, L., Shiklomanov, A.I., Shiklomanov, N.I., Siegel, D.A., Signorini, S.R., Sima, F., Simmons, A.J., Smeets, C.J.P.P., Smith, S.L., Spence, J.M., Srivastava, A.K., Stackhouse, P.W., Stammerjohn, S., Steinbrecht, W., Stella, J.L., Stengel, M., Stennett-Brown, R., Stephenson, T.S., Strahan, S., Streletskiy, D.A., Sun-Mack, S., Swart, S., Sweet, W., Talley, L.D., Tamar, G., Tank, S.E., Taylor, M.A., Tedesco, M., Teubner, K., Thoman, R.L., Thompson, P., Thomson, L., Timmermans, M.-L., Tirnanes, J.A., Tobin, S., Trachte, K., Trainer, V.L., Tretiakov, M., Trewin, B.C., Trotman, A.R., Tschudi, M., Van As, D., Van De Wal, R.S.W., van der A., R.J., Van Der Schalie, R., Van Der Schrier, G., Van Der Werf, G.R., Van Meerbeeck, C.J., Velicogna, I., Verburg, P., Vigneswaran, B., Vincent, L.A., Volkov, D., Vose, R.S., Wagner, W., Wåhlin, A., Wahr, J., Walsh, J., Wang, C., Wang, J., Wang, L., Wang, M., Wang, S.-H., Wanninkhof, R., Watanabe, S., Weber, M., Weller, R.A., Weyhenmeyer, G.A., Whitewood, R., Wijffels, S.E., Wilber, A.C., Wild, J.D., Willett, K.M., Williams, M.J.M., Willie, S., Wolken, G., Wong, T., Wood, E.F., Woolway, R.I., Wouters, B., Xue, Y., Yamada, R., Yim, S.-Y., Yin, X., Young, S.H., Yu, L., Zahid, H., Zambrano, E., Zhang, P., Zhao, G., Zhou, L., Ziemke, J.R., Love-Brotak, S.E., Gilbert, K., Maycock, T., Osborne, S., Sprain, M., Veasey, S.W., Ambrose, B.J., Griffin, J., Misch, D.J., Riddle, D.B., Young, T., Marine and Atmospheric Research, Sub Inorganic Chemistry and Catalysis, Sub Dynamics Meteorology, Sub Soft Condensed Matter, Sub Molecular Microbiology, Sub Physics of devices begr 1/1/17, LS Logica en grondslagen v.d. wiskunde, Sub SIM overig, Zonder bezoldiging NED, Sub General Pharmaceutics, Sub Algemeen Artificial Intelligence, Dynamics of Innovation Systems, Leerstoel Tubergen, Sub Chemical pharmacology, Hafd Faculteitsbureau GW, Sub IER overig, Sub Gen. Pharmacoepi and Clinical Pharm, LS Pharma, Dep IRAS, Environmental Sciences, Environmental Governance, Bureau AW, Sub Ecology and Biodiversity, Marine and Atmospheric Research, Sub Inorganic Chemistry and Catalysis, Sub Dynamics Meteorology, Sub Soft Condensed Matter, Sub Molecular Microbiology, Sub Physics of devices begr 1/1/17, LS Logica en grondslagen v.d. wiskunde, Sub SIM overig, Zonder bezoldiging NED, Sub General Pharmaceutics, Sub Algemeen Artificial Intelligence, Dynamics of Innovation Systems, Leerstoel Tubergen, Sub Chemical pharmacology, Hafd Faculteitsbureau GW, Sub IER overig, Sub Gen. Pharmacoepi and Clinical Pharm, LS Pharma, Dep IRAS, Environmental Sciences, Environmental Governance, Bureau AW, Sub Ecology and Biodiversity, Earth and Climate, Vrije Universiteit Amsterdam, Faculty of Earth and Life Sciences, and Climate Change and Landscape Dynamics

Subjects
Surface (mathematics), Atmospheric Science, 010504 meteorology & atmospheric sciences, 0208 environmental biotechnology, Mineralogy, 02 engineering and technology, 15. Life on land, 01 natural sciences, 020801 environmental engineering, 13. Climate action, F331 Atmospheric Physics, SDG 13 - Climate Action, SDG 14 - Life Below Water, Geology, 0105 earth and related environmental sciences
Abstract

SxviAUGUST 2016|ABSTRACT—J. BLUNDEN AND D. S. ARNDTIn 2015, the dominant greenhouse gases released into Earth’s atmosphere—carbon dioxide, methane, and nitrous oxide—all continued to reach new high levels. At Mauna Loa, Hawaii, the annual CO2 concentration increased by a record 3.1 ppm, exceeding 400 ppm for the first time on record. The 2015 global CO2 average neared this threshold, at 399.4 ppm. Additionally, one of the strongest El Niño events since at least 1950 developed in spring 2015 and continued to evolve through the year. The phenomenon was far reaching, impacting many regions across the globe and affecting most aspects of the climate system.Owing to the combination of El Niño and a long-term up-ward trend, Earth observed record warmth for the second con-secutive year, with the 2015 annual global surface temperature surpassing the previous record by more than 0.1°C and exceed-ing the average for the mid- to late 19th century—commonly considered representative of preindustrial conditions—by more than 1°C for the first time. Above Earth’s surface, lower troposphere temperatures were near-record high.Across land surfaces, record to near-record warmth was reported across every inhabited continent. Twelve countries, including Russia and China, reported record high annual tem-peratures. In June, one of the most severe heat waves since 1980 affected Karachi, Pakistan, claiming over 1000 lives. On 27 October, Vredendal, South Africa, reached 48.4°C, a new global high temperature record for this month. In the Arctic, the 2015 land surface temperature was 1.2°C above the 1981–2010 average, tying 2007 and 2011 for the high-est annual temperature and representing a 2.8°C increase since the record began in 1900. Increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 25 February 2015, the lowest maximum sea ice extent in the 37-year satel-lite record was observed, 7% below the 1981–2010 average. Mean sea surface temperatures across the Arctic Ocean dur-ing August in ice-free regions, representative of Arctic Ocean summer anomalies, ranged from ~0°C to 8°C above average. As a consequence of sea ice retreat and warming oceans, vast walrus herds in the Pacific Arctic are hauling out on land rather than on sea ice, raising concern about the energetics of females and young animals. Increasing temperatures in the Barents Sea are linked to a community-wide shift in fish populations: boreal communities are now farther north, and long-standing Arctic species have been almost pushed out of the area.Above average sea surface temperatures are not confined to the Arctic. Sea surface temperature for 2015 was record high at the global scale; however, the North Atlantic southeast of Greenland remained colder than average and colder than 2014. Global annual ocean heat content and mean sea level also reached new record highs. The Greenland Ice Sheet, with the capacity to contribute ~7 m to sea level rise, experienced melting over more than 50% of its surface for the first time since the record melt of 2012.Other aspects of the cryosphere were remarkable. Alpine glacier retreat continued, and preliminary data indicate that 2015 is the 36th consecutive year of negative annual mass balance. Across the Northern Hemisphere, late-spring snow cover extent continued its trend of decline, with June the sec-ond lowest in the 49-year satellite record. Below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska, increasing by up to 0.66°C decade–1 since 2000. In the Antarctic, surface pressure and temperatures were lower than the 1981–2010 average for most of the year, consis-tent with the primarily positive southern annular mode, which saw a record high index value of +4.92 in February. Antarctic sea ice extent and area had large intra-annual variability, with a shift from record high levels in May to record low levels in August. Springtime ozone depletion resulted in one of the largest and most persistent Antarctic ozone holes observed since the 1990s.Closer to the equator, 101 named tropical storms were observed in 2015, well above the 1981–2010 average of 82. The eastern/central Pacific had 26 named storms, the most since 1992. The western north Pacific and north and south Indian Ocean basins also saw high activity. Globally, eight tropical cyclones reached the Saffir–Simpson Category 5 intensity level.Overlaying a general increase in the hydrologic cycle, the strong El Niño enhanced precipitation variability around the world. An above-normal rainy season led to major floods in Paraguay, Bolivia, and southern Brazil. In May, the United States recorded its all-time wettest month in its 121-year national record. Denmark and Norway reported their second and third wettest year on record, respectively, but globally soil moisture was below average, terrestrial groundwater storage was the lowest in the 14-year record, and areas in “severe” drought rose from 8% in 2014 to 14% in 2015. Drought conditions prevailed across many Caribbean island nations, Colombia, Venezuela, and northeast Brazil for most of the year. Several South Pacific countries also experienced drought. Lack of rainfall across Ethiopia led to its worst drought in decades and affected millions of people, while prolonged drought in South Africa severely affected agricultural production. Indian summer monsoon rainfall was just 86% of average. Extremely dry conditions in Indonesia resulted in intense and widespread fires during August–November that produced abundant car-bonaceous aerosols, carbon monoxide, and ozone. Overall, emissions from tropical Asian biomass burning in 2015 were almost three times the 2001–14 average.

Published
2016

272. Validation of self-reports for use in contact research

Author

Sharp, M and Hewstone, M

Subjects
Social influence, Attitudes, Internet and everyday life, Experimental psychology, Stereotyping and intergroup relations, Intergroup conflict, Social psychology, Interpersonal behaviour
Abstract

The aim of this thesis was to investigate whether self-report measures of contact are valid for use in research testing the ‘contact hypothesis’. The vast majority of contact research has relied on the assumed validity of self-report methods of data collection (Pettigrew & Tropp, 2006), even though the potential weaknesses of self-report methodology generally have been well documented. This reliance is necessary, as self-reports remain the only practical method so far developed of measuring certain of the facilitating conditions developed by Allport (1954/1979), and particularly of direct and indirect cross-group friendship (Pettigrew, 1998; Wright, Aron, McLaughlin-Volpe, & Ropp, 1997). However, if self-reports are not a valid method for measuring contact, the derived implications of a large portion of the research effort are potentially flawed. This thesis attempted to address this important oversight, using a variety of methods to investigate whether the use of self-reports in future research on intergroup contact is appropriate. Studies 1 and 2 demonstrated that self-reports of contact show considerable resistance to context effects, particularly in comparison with self-reports of the more subjective construct of attitudes. Studies 3-5 demonstrated that self-reports of contact agree with the observer-reports of a single observer who knows the target intimately – the spouse or parent. Studies 6 and 7 replicate this agreement through the consensually supported observer-reports of three close friends of the target, thereby reducing any variance due to individual response biases. Finally, studies 8 and 9 demonstrate the concurrent criterion-related validity of self-reports of contact, in that they are able to predict contact on a very large online network called Facebook, on which real-world rather than purely online friendships are primarily represented. These findings offer considerable support for the validity of self-reports as a suitable method for measuring contact. As self-reports remain the only method which has thus far proven suitable for the measurement of those aspects of contact which are essential for exploration of the contact hypothesis, this thesis presents a very heartening and optimistic conclusion and supports the continued use of self-reports in contact research.

Published
2016

274. Erasures From The "Register"

Author

Noone, P., Slack, R. C. B., Parsons, T. M. C., Pattison, G. R., Rook, G., Boswell, P. A., Grange, J. M., Choudury, C., Cusworth, J. M., Kumar, P. J., Hewlitt, C. J., Thompson, M. K., Rossdale, M. R., Jones, R. M., Leathem, A., Mead, G. M., Williams, Y., Tudway, A., Mahmud, A., Stewart, J., Williams, H., Kerr, J. D., McMichael, H. B., Tewson, P., Ralphs, D., Brown, A. D. G., Wolff, C., Stanford, J. L., Brook, A. S., Shepherd, M., Bannerman, C., Todd, P. J., Aspinall, J. S., Knight, N., Norris, R. M., Webb, P., Smith, D. Warbit, Rutter, D., Unsworth, P., Cheetham, D., Dodman, S., Peskett, S., Gordon, D., Williams, J., McGavin, C., Cockrane, J., Davies, J. R., Nafatalin, A. P., Miller, R., Lightman, S., Hardy, R., Sharp, M. D. Buckley, Harrison, M., and Morris, T.

Published
1972

275. G.M.C. Retention Fee

Author

Alabaster, O., Andrews, R. J., Austwick, D. H., Beardshaw, Judith, Birch, Angela M., Biswas, S. K., Buckley-Sharp, M. D., Casson, Jennifer A., Cowie, J., Cummings, J. H., Cushnie, Josephine M., Dyson, Jennifer L., Elliott, B., Fahmy, S., Friedman, Bridget A., Friedman, P., Fullman, P. M., Goradia, D. T., Haas, J., Haworth, Kathleen S., Holt, S., Hopkins, C. D., Ickringhill, J. C. W., Impallomeni, M., Jalalluddin, M. K., Karmi, G., Kelly, M. B., Levis, R. D., McMichael, H. B., McNicol, M. W., Mackie, B., Mehta, A., Meyer, R. A., Mills, G. L., Mikhail, J. R., Mistry, Nargie, Mistry, V. G., Munshi, F. R., Newcombe, J. F., Noone, P., Ogunlesi, T. O. O., Parker-Williams, J., Phemister, J., Poston, R., Prempeh, T. D., Pygott, F., Radwanski, Z., Rao, S., Redfern, M., Riordan, J. F., Shawdon, H., Steinberg, V. L., Stephens, Mary E. M., Stern, R. B., Taylor, E., Davies, W. Tudor, Vanhein-Wallace, S. E., Kumar, S. Vijay, Vohra, S. L., Williams, J., and Young, J. R. B.

Published
1970

283. State of the Climate in 2014

Author

Aaron-Morrison, Arlene P., Ackerman, Steven A., Adams, Nicolaus G., Adler, Robert F., Albanil, Adelina, Alfaro, E. J., Allan, Rob, Alves, Lincoln M., Amador, Jorge A., Andreassen, L. M., Arendt, A., Arévalo, Juan, Arndt, Derek S., Arzhanova, N. M., Aschan, M. M., Azorin-Molina, César, Banzon, Viva, Bardin, M. U., Barichivich, Jonathan, Baringer, Molly O., Barreira, Sandra, Baxter, Stephen, Bazo, Juan, Becker, Andreas, Bedka, Kristopher M., Behrenfeld, Michael J., Bell, Gerald D., Belmont, M., Benedetti, Angela, Bernhard, G., Berrisford, Paul, Berry, David I., Bettolli, María L., Bhatt, U. S., Bidegain, Mario, Bill, Brian D., Billheimer, Sam, Bissolli, Peter, Blake, Eric S., Blunden, Jessica, Bosilovich, Michael G., Boucher, Olivier, Boudet, Dagne, Box, J. E., Boyer, Tim, Braathen, Geir O., Bromwich, David H., Brown, R., Bulygina, Olga N., Burgess, D., Calderón, Blanca, Camargo, Suzana J., Campbell, Jayaka D., Cappelen, J., Carrasco, Gualberto, Carter, Brendan R., Chambers, Don P., Chandler, Elise, Christiansen, Hanne H., Christy, John R., Chung, Daniel, Chung, E. S., Cinque, Kathy, Clem, Kyle R., Coelho, Caio A., Cogley, J. G., Coldewey-Egbers, Melanie, Colwell, Steve, Cooper, Owen R., Copland, L., Cosca, Catherine E., Cross, Jessica N., Crotwell, Molly J., Crouch, Jake, Davis, Sean M., De Eyto, Elvira, De Jeu, Richard A.M., De Laat, Jos, Degasperi, Curtis L., Degenstein, Doug, Demircan, M., Derksen, C., Destin, Dale, Di Girolamo, Larry, Di Giuseppe, F., Diamond, Howard J., Dlugokencky, Ed J., Dohan, Kathleen, Dokulil, Martin T., Dolgov, A. V., Dolman, A. Johannes, Domingues, Catia M., Donat, Markus G., Dong, Shenfu, Dorigo, Wouter A., Dortch, Quay, Doucette, Greg, Drozdov, D. S., Ducklow, Hugh, Dunn, Robert J.H., Durán-Quesada, Ana M., Dutton, Geoff S., Ebrahim, A., Elkharrim, M., Elkins, James W., Espinoza, Jhan C., Etienne-Leblanc, Sheryl, Evans, Thomas E., Famiglietti, James S., Farrell, S., Fateh, S., Fausto, Robert S., Fedaeff, Nava, Feely, Richard A., Feng, Z., Fenimore, Chris, Fettweis, X., Fioletov, Vitali E., Flemming, Johannes, Fogarty, Chris T., Fogt, Ryan L., Folland, Chris, Fonseca, C., Fossheim, M., Foster, Michael J., Fountain, Andrew, Francis, S. D., Franz, Bryan A., Frey, Richard A., Frith, Stacey M., Froidevaux, Lucien, Ganter, Catherine, Garzoli, Silvia, Gerland, S., Gobron, Nadine, Goldenberg, Stanley B., Gomez, R. Sorbonne, Goni, Gustavo, Goto, A., Grooß, J. U., Gruber, Alexander, Guard, Charles Chip, Gugliemin, Mauro, Gupta, S. K., Gutiérrez, J. M., Hagos, S., Hahn, Sebastian, Haimberger, Leo, Hakkarainen, J., Hall, Brad D., Halpert, Michael S., Hamlington, Benjamin D., Hanna, E., Hansen, K., Hanssen-Bauer, I., Harris, Ian, Heidinger, Andrew K., Heikkilä, A., Heil, A., Heim, Richard R., Hendricks, S., Hernández, Marieta, Hidalgo, Hugo G., Hilburn, Kyle, Ho, Shu Peng Ben, Holmes, R. M., Hu, Zeng Zhen, Huang, Boyin, Huelsing, Hannah K., Huffman, George J., Hughes, C., Hurst, Dale F., Ialongo, I., Ijampy, J. A., Ingvaldsen, R. B., Inness, Antje, Isaksen, K., Ishii, Masayoshi, Jevrejeva, Svetlana, Jiménez, C., Jin, Xiangze, Johannesen, E., John, Viju, Johnsen, B., Johnson, Bryan, Johnson, Gregory C., Jones, Philip D., Joseph, Annie C., Jumaux, Guillaume, Kabidi, Khadija, Kaiser, Johannes W., Kato, Seiji, Kazemi, A., Keller, Linda M., Kendon, Mike, Kennedy, John, Kerr, Kenneth, Kholodov, A. L., Khoshkam, Mahbobeh, Killick, Rachel, Kim, Hyungjun, Kim, S. J., Kimberlain, Todd B., Klotzbach, Philip J., Knaff, John A., Kobayashi, Shinya, Kohler, J., Korhonen, Johanna, Korshunova, Natalia N., Kovacs, K. M., Kramarova, Natalya, Kratz, D. P., Kruger, Andries, Kruk, Michael C., Kudela, Raphael, Kumar, Arun, Lakatos, M., Lakkala, K., Lander, Mark A., Landsea, Chris W., Lankhorst, Matthias, Lantz, Kathleen, Lazzara, Matthew A., Lemons, P., Leuliette, Eric, L’Heureux, Michelle, Lieser, Jan L., Lin, I. I., Liu, Hongxing, Liu, Yinghui, Locarnini, Ricardo, Loeb, Norman G., Lo Monaco, Claire, Long, Craig S., López Álvarez, Luis Alfonso, Lorrey, Andrew M., Loyola, Diego, Lumpkin, Rick, Luo, Jing Jia, Luojus, K., Lydersen, C., Lyman, John M., Maberly, Stephen C., Maddux, Brent C., Malheiros Ramos, Andrea, Malkova, G. V., Manney, G., Marcellin, Vernie, Marchenko, S. S., Marengo, José A., Marra, John J., Marszelewski, Wlodzimierz, Martens, B., Martínez-Güingla, Rodney, Massom, Robert A., Mata, Mauricio M., Mathis, Jeremy T., May, Linda, Mayer, Michael, Mazloff, Matthew, McBride, Charlotte, McCabe, M. F., McCarthy, M., McClelland, J. W., McGree, Simon, McVicar, Tim R., Mears, Carl A., Meier, W., Meinen, Christopher S., Mekonnen, A., Menéndez, Melisa, Mengistu Tsidu, G., Menzel, W. Paul, Merchant, Christopher J., Meredith, Michael P., Merrifield, Mark A., Metzl, N., Minnis, Patrick, Miralles, Diego G., Mistelbauer, T., Mitchum, Gary T., Monselesan, Didier, Monteiro, Pedro, Montzka, Stephen A., Morice, Colin, Mote, T., Mudryk, L., Mühle, Jens, Mullan, A. Brett, Nash, Eric R., Naveira-Garabato, Alberto C., Nerem, R. Steven, Newman, Paul A., Nieto, Juan José, Noetzli, Jeannette, O’Neel, S., Osborn, Tim J., Overland, J., Oyunjargal, Lamjav, Parinussa, Robert M., Park, E. Hyung, Parker, David, Parrington, M., Parsons, A. Rost, Pasch, Richard J., Pascual-Ramírez, Reynaldo, Paterson, Andrew M., Paulik, Christoph, Pearce, Petra R., Pelto, Mauri S., Peng, Liang, Perkins-Kirkpatrick, Sarah E., Perovich, D., Petropavlovskikh, Irina, Pezza, Alexandre B., Phillips, David, Pinty, Bernard, Pitts, Michael C., Pons, M. R., Porter, Avalon O., Primicerio, R., Proshutinsky, A., Quegan, Sean, Quintana, Juan, Rahimzadeh, Fatemeh, Rajeevan, Madhavan, Randriamarolaza, L., Razuvaev, Vyacheslav N., Reagan, James, Reid, Phillip, Reimer, Christoph, Rémy, Samuel, Renwick, James A., Revadekar, Jayashree V., Richter-Menge, J., Riffler, Michael, Rimmer, Alon, Rintoul, Steve, Robinson, David A., Rodell, Matthew, Rodríguez Solís, José L., Romanovsky, Vladimir E., Ronchail, Josyane, Rosenlof, Karen H., Roth, Chris, Rusak, James A., Sabine, Christopher L., Sallée, Jean Bapiste, Sánchez-Lugo, Ahira, Santee, Michelle L., Sawaengphokhai, P., Sayouri, Amal, Scambos, Ted A., Schemm, Jae, Schladow, S. Geoffrey, Schmid, Claudia, Schmid, Martin, Schmidtko, Sunke, Schreck, Carl J., Selkirk, H. B., Send, Uwe, Sensoy, Serhat, Setzer, Alberto, Sharp, M., Shaw, Adrian, Shi, Lei, Shiklomanov, A. I., Shiklomanov, Nikolai I., Siegel, David A., Signorini, Sergio R., Sima, Fatou, Simmons, Adrian J., Smeets, C. J.P.P., Smith, Sharon L., Spence, Jaqueline M., Srivastava, A. K., Stackhouse, Paul W., Stammerjohn, Sharon, Steinbrecht, Wolfgang, Stella, José L., Stengel, Martin, Stennett-Brown, Roxann, Stephenson, Tannecia S., Strahan, Susan, Streletskiy, D. A., Sun-Mack, Sunny, Swart, Sebastiaan, Sweet, William, Talley, Lynne D., Tamar, Gerard, Tank, S. E., Taylor, Michael A., Tedesco, M., Teubner, Katrin, Thoman, R. L., Thompson, Philip, Thomson, L., Timmermans, M. L., Tirnanes, Joaquin A., Tobin, Skie, Trachte, Katja, Trainer, Vera L., Tretiakov, M., Trewin, Blair C., Trotman, Adrian R., Tschudi, M., Van As, D., Van De Wal, R. S.W., van der A., Ronald J., Van Der Schalie, Robin, Van Der Schrier, Gerard, Van Der Werf, Guido R., Van Meerbeeck, Cedric J., Velicogna, I., Verburg, Piet, Vigneswaran, Bala, Vincent, Lucie A., Volkov, Denis, Vose, Russell S., Wagner, Wolfgang, Wåhlin, Anna, Wahr, J., Walsh, J., Wang, Chunzai, Wang, Junhong, Wang, Lei, Wang, M., Wang, Sheng Hung, Wanninkhof, Rik, Watanabe, Shohei, Weber, Mark, Weller, Robert A., Weyhenmeyer, Gesa A., Whitewood, Robert, Wijffels, Susan E., Wilber, Anne C., Wild, Jeanette D., Willett, Kate M., Williams, Michael J.M., Willie, Shem, Wolken, G., Wong, Takmeng, Wood, E. F., Woolway, R. Iestyn, Wouters, B., Xue, Yan, Yamada, Ryuji, Yim, So Young, Yin, Xungang, Young, Steven H., Yu, Lisan, Zahid, H., Zambrano, Eduardo, Zhang, Peiqun, Zhao, Guanguo, Zhou, Lin, Ziemke, Jerry R., Love-Brotak, S. Elizabeth, Gilbert, Kristin, Maycock, Tom, Osborne, Susan, Sprain, Mara, Veasey, Sara W., Ambrose, Barbara J., Griffin, Jessicca, Misch, Deborah J., Riddle, Deborah B., Young, Teresa, Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), ICOS-ATC (ICOS-ATC), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Modélisation INVerse pour les mesures atmosphériques et SATellitaires (SATINV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and Earth and Climate

Subjects
0106 biological sciences, [SDU.OCEAN]Sciences of the Universe [physics]/Ocean, Atmosphere, Atmospheric Science, 010504 meteorology & atmospheric sciences, 010604 marine biology & hydrobiology, Perspective (graphical), 15. Life on land, 01 natural sciences, El Niño Southern Oscillation, 13. Climate action, Climatology, SDG 13 - Climate Action, Environmental science, SDG 14 - Life Below Water, [SDU.ENVI]Sciences of the Universe [physics]/Continental interfaces, environment, ComputingMilieux_MISCELLANEOUS, 0105 earth and related environmental sciences
Abstract

Most of the dozens of essential climate variables monitored each year in this report continued to follow their long-term trends in 2014, with several setting new records. Carbon dioxide, methane, and nitrous oxide-the major greenhouse gases released into Earth's atmosphere-once again all reached record high average atmospheric concentrations for the year. Carbon dioxide increased by 1.9 ppm to reach a globally averaged value of 397.2 ppm for 2014. Altogether, 5 major and 15 minor greenhouse gases contributed 2.94 W m-2 of direct radiative forcing, which is 36% greater than their contributions just a quarter century ago. Accompanying the record-high greenhouse gas concentrations was nominally the highest annual global surface temperature in at least 135 years of modern record keeping, according to four independent observational analyses. The warmth was distributed widely around the globe's land areas, Europe observed its warmest year on record by a large margin, with close to two dozen countries breaking their previous national temperature records; many countries in Asia had annual temperatures among their 10 warmest on record; Africa reported above-average temperatures across most of the continent throughout 2014; Australia saw its third warmest year on record, following record heat there in 2013; Mexico had its warmest year on record; and Argentina and Uruguay each had their second warmest year on record. Eastern North America was the only major region to observe a below-average annual temperature. But it was the oceans that drove the record global surface temperature in 2014. Although 2014 was largely ENSO-neutral, the globally averaged sea surface temperature (SST) was the highest on record. The warmth was particularly notable in the North Pacific Ocean where SST anomalies signaled a transition from a negative to positive phase of the Pacific decadal oscillation. In the winter of 2013/14, unusually warm water in the northeast Pacific was associated with elevated ocean heat content anomalies and elevated sea level in the region. Globally, upper ocean heat content was record high for the year, reflecting the continued increase of thermal energy in the oceans, which absorb over 90% of Earth's excess heat from greenhouse gas forcing. Owing to both ocean warming and land ice melt contributions, global mean sea level in 2014 was also record high and 67 mm greater than the 1993 annual mean, when satellite altimetry measurements began. Sea surface salinity trends over the past decade indicate that salty regions grew saltier while fresh regions became fresher, suggestive of an increased hydrological cycle over the ocean expected with global warming. As in previous years, these patterns are reflected in 2014 subsurface salinity anomalies as well. With a now decade-long trans-basin instrument array along 26°N, the Atlantic meridional overturning circulation shows a decrease in transport of-4.2 ± 2.5 Sv decade-1. Precipitation was quite variable across the globe. On balance, precipitation over the world's oceans was above average, while below average across land surfaces. Drought continued in southeastern Brazil and the western United States. Heavy rain during April-June led to devastating floods in Canada's Eastern Prairies. Above-normal summer monsoon rainfall was observed over the southern coast of West Africa, while drier conditions prevailed over the eastern Sahel. Generally, summer monsoon rainfall over eastern Africa was above normal, except in parts of western South Sudan and Ethiopia. The south Asian summer monsoon in India was below normal, with June record dry. Across the major tropical cyclone basins, 91 named storms were observed during 2014, above the 1981-2010 global average of 82. The Eastern/Central Pacific and South Indian Ocean basins experienced significantly above-normal activity in 2014; all other basins were either at or below normal. The 22 named storms in the Eastern/Central Pacific was the basin's most since 1992. Similar to 2013, the North Atlantic season was quieter than most years of the last two decades with respect to the number of storms, despite the absence of El Niño conditions during both years. In higher latitudes and at higher elevations, increased warming continued to be visible in the decline of glacier mass balance, increasing permafrost temperatures, and a deeper thawing layer in seasonally frozen soil. In the Arctic, the 2014 temperature over land areas was the fourth highest in the 115-year period of record and snow melt occurred 20-30 days earlier than the 1998-2010 average. The Greenland Ice Sheet experienced extensive melting in summer 2014. The extent of melting was above the 1981-2010 average for 90% of the melt season, contributing to the second lowest average summer albedo over Greenland since observations began in 2000 and a record-low albedo across the ice sheet for August. On the North Slope of Alaska, new record high temperatures at 20-m depth were measured at four of five permafrost observatories. In September, Arctic minimum sea ice extent was the sixth lowest since satellite records began in 1979. The eight lowest sea ice extents during this period have occurred in the last eight years. Conversely, in the Antarctic, sea ice extent countered its declining trend and set several new records in 2014, including record high monthly mean sea ice extent each month from April to November. On 20 September, a record large daily Antarctic sea ice extent of 20.14 × 106 km2 occurred. The 2014 Antarctic stratospheric ozone hole was 20.9 million km2 when averaged from 7 September to 13 October, the sixth smallest on record and continuing a decrease, albeit statistically insignificant, in area since 1998.

Published
2015

285. Diversifying the use of tuna to improve food security and public health in Pacific Island countries and territories

Author

Bell, J. D., Allain, V., Allison, E. H., Andréfouët, Serge, Andrew, N. L., Batty, M. J., Blanc, M., Dambacher, J. M., Hampton, J., Hanich, Q., Harley, S., Lorrain, Anne, McCoy, M., McTurk, N., Nicol, S., Pilling, G., Point, David, Sharp, M. K., Vivili, P., and Williams, P.

Subjects
Tuna, Population growth, Food security, Non-communicable diseases, Pacific Islands
Abstract

The large tuna resources of the Western and Central Pacific Ocean are delivering great economic benefits to Pacific Island countries and territories (PICTs) through sale of licences to distant water fishing nations and employment in fish processing. However, tuna needs to contribute to Pacific Island societies in another important way by increasing local access to the fish required for good nutrition to help combat the world's highest levels of diabetes and obesity. Analyses reported here demonstrate that coastal fisheries in 16 of the 22 PICTs will not provide the fish recommended for good nutrition of growing Pacific Island populations, and that by 2020 tuna will need to supply 12% of the fish required by PICTs for food security, increasing to 25% by 2035. In relative terms, the percentages of the region's tuna catch that will be needed in 2020 and 2035 to fill the gap in domestic fish supply are small, i.e., 2.1% and 5.9% of the average present-day industrial catch, respectively. Interventions based on expanding the use of nearshore fish aggregating devices (FADs) to assist small-scale fishers catch tuna, distributing small tuna and bycatch offloaded by industrial fleets at regional ports, and improving access to canned tuna for inland populations, promise to increase access to fish for sustaining the health of the region's growing populations. The actions, research and policies required to implement these interventions effectively, and the investments needed to maintain the stocks underpinning the considerable socio-economic benefits that flow from tuna, are described.

Published
2015

286. The fine anatomy of the perivascular compartment in the human brain: relevance to dilated perivascular spaces in cerebral amyloid angiopathy.

Author

MacGregor Sharp, M., Bulters, D., Carare, R. O., Brandner, S., Holton, J., Werring, D. J., and Verma, A.

Subjects
*WHITE matter (Nerve tissue), *BRAIN damage, *CEREBRAL amyloid angiopathy, *COGNITION disorders, *OLDER people
Abstract

The article talks about cerebral white matter hyperintensities (WMHs) are lesions in the brain that show up as areas of increased brightness when visualised by T2-weighted magnetic resonance imaging (MRI). It is mentioned that prevailing view is that these intensities are a marker of small-vessel vascular disease and cerebral amyloid angiopathy, are indicative of cognitive and emotional dysfunction. The article adds most affected by this disorder are elderly populations.

Published
2019
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287. Microscopic Relaxation Processes in Branched-Linear Polymer Blends by Rheo-SANS

Author

Ruocco, N., Dahbi, L., Driva, P., Hadjichristidis, N., Allgaier, J., Radulescu, A., Sharp, M., Lindner, P., Straube, E., Pyckhout-Hintzen, W., and Richter, D.

Abstract

The relaxation time spectrum in blends of architecturally different polymers with strongly disperse time scales has been investigated by their time-dependent small angle neutron scattering signal after a fast uniaxial step strain. Model-hyperbranched dendrimeric polymers of second generation, dilutely dispersed within linear homopolymer matrices, acted like sensitive probes for structurally, though not firmly, established features of the tube model for bidisperse melts. We showed that the equilibration time of the linear matrix determines the size of the fluctuations that the outer and inner arms experience. Within a random phase approximation (RPA) treatment, which accounts for the different degrees of freedom inherent to the broad time scales, the observed loss of anisotropy with time was described in terms of two parameters only, namely the tube diameter and the fraction of relaxed arms of the minority component. The scattering data reveal details of mechanisms, which cannot be extracted from but determine the macroscopic flow properties. At intermediate times, a tube relaxation process was detected. At long times, the dynamic dilution model is confirmed.

Published
2024
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288. State of the climate in 2015

Author

Marine and Atmospheric Research, Sub Inorganic Chemistry and Catalysis, Sub Dynamics Meteorology, Sub Soft Condensed Matter, Sub Molecular Microbiology, Sub Physics of devices begr 1/1/17, LS Logica en grondslagen v.d. wiskunde, Sub SIM overig, Zonder bezoldiging NED, Sub General Pharmaceutics, Sub Algemeen Artificial Intelligence, Dynamics of Innovation Systems, Leerstoel Tubergen, Sub Chemical pharmacology, Hafd Faculteitsbureau GW, Sub ISEP overig, Sub Gen. Pharmacoepi and Clinical Pharm, LS Pharma, Dep IRAS, Environmental Sciences, Environmental Governance, Bureau AW, Sub Ecology and Biodiversity, Aaron-Morrison, A.P., Ackerman, S.A., Adams, N.G., Adler, R.F., Albanil, A., Alfaro, E.J., Allan, R., Alves, L.M., Amador, J.A., Andreassen, L.M., Arendt, A., Arévalo, J., Arndt, D.S., Arzhanova, N.M., Aschan, M.M., Azorin-Molina, C., Banzon, V., Bardin, M.U., Barichivich, J., Baringer, M.O., Barreira, S., Baxter, S., Bazo, J., Becker, A., Bedka, K.M., Behrenfeld, M.J., Bell, G.D., Belmont, M., Benedetti, A., Bernhard, G., Berrisford, P., Berry, D.I., Bettolli, M.L., Bhatt, U.S., Bidegain, M., Bill, B.D., Billheimer, S., Bissolli, P., Blake, E.S., Blunden, J., Bosilovich, M.G., Boucher, O., Boudet, D., Box, J.E., Boyer, T., Braathen, G.O., Bromwich, D.H., Brown, R., Bulygina, O.N., Burgess, D., Calderón, B., Camargo, S.J., Campbell, J.D., Cappelen, J., Carrasco, G., Carter, B.R., Chambers, D.P., Chandler, E., Christiansen, H.H., Christy, J.R., Chung, D., Chung, E.-S., Cinque, K., Clem, K.R., Coelho, C.A., Cogley, J.G., Coldewey-Egbers, M., Colwell, S., Cooper, O.R., Copland, L., Cosca, C.E., Cross, J.N., Crotwell, M.J., Crouch, J., Davis, S.M., De Eyto, E., De Jeu, R.A.M., De Laat, J., Degasperi, C.L., Degenstein, D., Demircan, M., Derksen, C., Destin, D., Di Girolamo, L., Di Giuseppe, F., Diamond, H.J., Dlugokencky, E.J., Dohan, K., Dokulil, M.T., Dolgov, A.V., Dolman, A.J., Domingues, C.M., Donat, M.G., Dong, S., Dorigo, W.A., Dortch, Q., Doucette, G., Drozdov, D.S., Ducklow, H., Dunn, R.J.H., Durán-Quesada, A.M., Dutton, G.S., Ebrahim, A., Elkharrim, M., Elkins, J.W., Espinoza, J.C., Etienne-Leblanc, S., Evans, T.E., Famiglietti, J.S., Farrell, S., Fateh, S., Fausto, R.S., Fedaeff, N., Feely, R.A., Feng, Z., Fenimore, C., Fettweis, X., Fioletov, V.E., Flemming, J., Fogarty, C.T., Fogt, R.L., Folland, C., Fonseca, C., Fossheim, M., Foster, M.J., Fountain, A., Francis, S.D., Franz, B.A., Frey, R.A., Frith, S.M., Froidevaux, L., Ganter, C., Garzoli, S., Gerland, S., Gobron, N., Goldenberg, S.B., Gomez, R.S., Goni, G., Goto, A., Grooß, J.-U., Gruber, A., Guard, C.C., Gugliemin, M., Gupta, Somil, Gutiérrez, J.M., Hagos, S., Hahn, S., Haimberger, L., Hakkarainen, J., Hall, B.D., Halpert, M.S., Hamlington, B.D., Hanna, E., Hansen, K., Hanssen-Bauer, I., Harris, I., Heidinger, A.K., Heikkilä, A., Heil, A., Heim, R.R., Hendricks, S., Hernández, M., Hidalgo, H.G., Hilburn, K., Ho, S.-P.B., Holmes, R.M., Hu, Z.-Z., Huang, B., Huelsing, H.K., Huffman, G.J., Hughes, C., Hurst, D.F., Ialongo, I., Ijampy, J.A., Ingvaldsen, R.B., Inness, A., Isaksen, K., Ishii, M., Jevrejeva, S., Jiménez, C., Jin, X., Johannesen, E., John, V., Johnsen, B., Johnson, B., Johnson, G.C., Jones, P.D., Joseph, A.C., Jumaux, G., Kabidi, K., Kaiser, J.W., Kato, S., Kazemi, A., Keller, L.M., Kendon, M., Kennedy, J., Kerr, K., Kholodov, A.L., Khoshkam, M., Killick, R., Kim, H., Kim, S.-J., Kimberlain, T.B., Klotzbach, P.J., Knaff, J.A., Kobayashi, S., Kohler, J., Korhonen, J., Korshunova, N.N., Kovacs, K.M., Kramarova, N., Kratz, D.P., Kruger, A., Kruk, M.C., Kudela, R., Kumar, A., Lakatos, M., Lakkala, K., Lander, M.A., Landsea, C.W., Lankhorst, M., Lantz, K., Lazzara, M.A., Lemons, P., Leuliette, E., L’Heureux, M., Lieser, J.L., Lin, I.-I., Liu, H., Liu, Y., Locarnini, R., Loeb, N.G., Lo Monaco, C., Long, C.S., López Álvarez, L.A., Lorrey, A.M., Loyola, D., Lumpkin, R., Luo, J.-J., Luojus, K., Lydersen, C., Lyman, J.M., Maberly, S.C., Maddux, B.C., Malheiros Ramos, A., Malkova, G.V., Manney, G., Marcellin, V., Marchenko, S.S., Marengo, J.A., Marra, J.J., Marszelewski, W., Martens, B., Martínez-Güingla, R., Massom, R.A., Mata, M.M., Mathis, J.T., May, L., Mayer, M., Mazloff, M., McBride, C., McCabe, M.F., McCarthy, M., McClelland, J.W., McGree, S., McVicar, T.R., Mears, C.A., Meier, W., Meinen, C.S., Mekonnen, A., Menéndez, M., Mengistu Tsidu, G., Menzel, W.P., Merchant, C.J., Meredith, M.P., Merrifield, M.A., Metzl, N., Minnis, P., Miralles, D.G., Mistelbauer, T., Mitchum, G.T., Monselesan, D., Monteiro, P., Montzka, S.A., Morice, C., Mote, T., Mudryk, L., Mühle, J., Mullan, A.B., Nash, E.R., Naveira-Garabato, A.C., Nerem, R.S., Newman, P.A., Nieto, J.J., Noetzli, J., O’Neel, S., Osborn, T.J., Overland, J., Oyunjargal, L., Parinussa, R.M., Park, E.-H., Parker, D., Parrington, M., Parsons, A.R., Pasch, R.J., Pascual-Ramírez, R., Paterson, A.M., Paulik, C., Pearce, P.R., Pelto, M.S., Peng, L., Perkins-Kirkpatrick, S.E., Perovich, D., Petropavlovskikh, I., Pezza, A.B., Phillips, D., Pinty, B., Pitts, M.C., Pons, M.R., Porter, A.O., Primicerio, R., Proshutinsky, A., Quegan, S., Quintana, J., Rahimzadeh, F., Rajeevan, M., Randriamarolaza, L., Razuvaev, V.N., Reagan, J., Reid, P., Reimer, C., Rémy, S., Renwick, J.A., Revadekar, J.V., Richter-Menge, J., Riffler, M., Rimmer, A., Rintoul, S., Robinson, D.A., Rodell, M., Rodríguez Solís, J.L., Romanovsky, V.E., Ronchail, J., Rosenlof, K.H., Roth, C., Rusak, J.A., Sabine, C.L., Sallée, J.-B., Sánchez-Lugo, A., Santee, M.L., Sawaengphokhai, P., Sayouri, A., Scambos, T.A., Schemm, J., Schladow, S.G., Schmid, C., Schmid, M., Schmidtko, S., Schreck, C.J., Selkirk, H.B., Send, U., Sensoy, S., Setzer, A., Sharp, M., Shaw, A., Shi, L., Shiklomanov, A.I., Shiklomanov, N.I., Siegel, D.A., Signorini, S.R., Sima, F., Simmons, A.J., Smeets, C.J.P.P., Smith, S.L., Spence, J.M., Srivastava, A.K., Stackhouse, P.W., Stammerjohn, S., Steinbrecht, W., Stella, J.L., Stengel, M., Stennett-Brown, R., Stephenson, T.S., Strahan, S., Streletskiy, D.A., Sun-Mack, S., Swart, S., Sweet, W., Talley, L.D., Tamar, G., Tank, S.E., Taylor, M.A., Tedesco, M., Teubner, K., Thoman, R.L., Thompson, P., Thomson, L., Timmermans, M.-L., Tirnanes, J.A., Tobin, S., Trachte, K., Trainer, V.L., Tretiakov, M., Trewin, B.C., Trotman, A.R., Tschudi, M., Van As, D., Van De Wal, R.S.W., van der A., R.J., Van Der Schalie, R., Van Der Schrier, G., Van Der Werf, G.R., Van Meerbeeck, C.J., Velicogna, I., Verburg, P., Vigneswaran, B., Vincent, L.A., Volkov, D., Vose, R.S., Wagner, W., Wåhlin, A., Wahr, J., Walsh, J., Wang, C., Wang, J., Wang, L., Wang, M., Wang, S.-H., Wanninkhof, R., Watanabe, S., Weber, M., Weller, R.A., Weyhenmeyer, G.A., Whitewood, R., Wijffels, S.E., Wilber, A.C., Wild, J.D., Willett, K.M., Williams, M.J.M., Willie, S., Wolken, G., Wong, T., Wood, E.F., Woolway, R.I., Wouters, B., Xue, Y., Yamada, R., Yim, S.-Y., Yin, X., Young, S.H., Yu, L., Zahid, H., Zambrano, E., Zhang, P., Zhao, G., Zhou, L., Ziemke, J.R., Love-Brotak, S.E., Gilbert, K., Maycock, T., Osborne, S., Sprain, M., Veasey, S.W., Ambrose, B.J., Griffin, J., Misch, D.J., Riddle, D.B., Young, T., Marine and Atmospheric Research, Sub Inorganic Chemistry and Catalysis, Sub Dynamics Meteorology, Sub Soft Condensed Matter, Sub Molecular Microbiology, Sub Physics of devices begr 1/1/17, LS Logica en grondslagen v.d. wiskunde, Sub SIM overig, Zonder bezoldiging NED, Sub General Pharmaceutics, Sub Algemeen Artificial Intelligence, Dynamics of Innovation Systems, Leerstoel Tubergen, Sub Chemical pharmacology, Hafd Faculteitsbureau GW, Sub ISEP overig, Sub Gen. Pharmacoepi and Clinical Pharm, LS Pharma, Dep IRAS, Environmental Sciences, Environmental Governance, Bureau AW, Sub Ecology and Biodiversity, Aaron-Morrison, A.P., Ackerman, S.A., Adams, N.G., Adler, R.F., Albanil, A., Alfaro, E.J., Allan, R., Alves, L.M., Amador, J.A., Andreassen, L.M., Arendt, A., Arévalo, J., Arndt, D.S., Arzhanova, N.M., Aschan, M.M., Azorin-Molina, C., Banzon, V., Bardin, M.U., Barichivich, J., Baringer, M.O., Barreira, S., Baxter, S., Bazo, J., Becker, A., Bedka, K.M., Behrenfeld, M.J., Bell, G.D., Belmont, M., Benedetti, A., Bernhard, G., Berrisford, P., Berry, D.I., Bettolli, M.L., Bhatt, U.S., Bidegain, M., Bill, B.D., Billheimer, S., Bissolli, P., Blake, E.S., Blunden, J., Bosilovich, M.G., Boucher, O., Boudet, D., Box, J.E., Boyer, T., Braathen, G.O., Bromwich, D.H., Brown, R., Bulygina, O.N., Burgess, D., Calderón, B., Camargo, S.J., Campbell, J.D., Cappelen, J., Carrasco, G., Carter, B.R., Chambers, D.P., Chandler, E., Christiansen, H.H., Christy, J.R., Chung, D., Chung, E.-S., Cinque, K., Clem, K.R., Coelho, C.A., Cogley, J.G., Coldewey-Egbers, M., Colwell, S., Cooper, O.R., Copland, L., Cosca, C.E., Cross, J.N., Crotwell, M.J., Crouch, J., Davis, S.M., De Eyto, E., De Jeu, R.A.M., De Laat, J., Degasperi, C.L., Degenstein, D., Demircan, M., Derksen, C., Destin, D., Di Girolamo, L., Di Giuseppe, F., Diamond, H.J., Dlugokencky, E.J., Dohan, K., Dokulil, M.T., Dolgov, A.V., Dolman, A.J., Domingues, C.M., Donat, M.G., Dong, S., Dorigo, W.A., Dortch, Q., Doucette, G., Drozdov, D.S., Ducklow, H., Dunn, R.J.H., Durán-Quesada, A.M., Dutton, G.S., Ebrahim, A., Elkharrim, M., Elkins, J.W., Espinoza, J.C., Etienne-Leblanc, S., Evans, T.E., Famiglietti, J.S., Farrell, S., Fateh, S., Fausto, R.S., Fedaeff, N., Feely, R.A., Feng, Z., Fenimore, C., Fettweis, X., Fioletov, V.E., Flemming, J., Fogarty, C.T., Fogt, R.L., Folland, C., Fonseca, C., Fossheim, M., Foster, M.J., Fountain, A., Francis, S.D., Franz, B.A., Frey, R.A., Frith, S.M., Froidevaux, L., Ganter, C., Garzoli, S., Gerland, S., Gobron, N., Goldenberg, S.B., Gomez, R.S., Goni, G., Goto, A., Grooß, J.-U., Gruber, A., Guard, C.C., Gugliemin, M., Gupta, Somil, Gutiérrez, J.M., Hagos, S., Hahn, S., Haimberger, L., Hakkarainen, J., Hall, B.D., Halpert, M.S., Hamlington, B.D., Hanna, E., Hansen, K., Hanssen-Bauer, I., Harris, I., Heidinger, A.K., Heikkilä, A., Heil, A., Heim, R.R., Hendricks, S., Hernández, M., Hidalgo, H.G., Hilburn, K., Ho, S.-P.B., Holmes, R.M., Hu, Z.-Z., Huang, B., Huelsing, H.K., Huffman, G.J., Hughes, C., Hurst, D.F., Ialongo, I., Ijampy, J.A., Ingvaldsen, R.B., Inness, A., Isaksen, K., Ishii, M., Jevrejeva, S., Jiménez, C., Jin, X., Johannesen, E., John, V., Johnsen, B., Johnson, B., Johnson, G.C., Jones, P.D., Joseph, A.C., Jumaux, G., Kabidi, K., Kaiser, J.W., Kato, S., Kazemi, A., Keller, L.M., Kendon, M., Kennedy, J., Kerr, K., Kholodov, A.L., Khoshkam, M., Killick, R., Kim, H., Kim, S.-J., Kimberlain, T.B., Klotzbach, P.J., Knaff, J.A., Kobayashi, S., Kohler, J., Korhonen, J., Korshunova, N.N., Kovacs, K.M., Kramarova, N., Kratz, D.P., Kruger, A., Kruk, M.C., Kudela, R., Kumar, A., Lakatos, M., Lakkala, K., Lander, M.A., Landsea, C.W., Lankhorst, M., Lantz, K., Lazzara, M.A., Lemons, P., Leuliette, E., L’Heureux, M., Lieser, J.L., Lin, I.-I., Liu, H., Liu, Y., Locarnini, R., Loeb, N.G., Lo Monaco, C., Long, C.S., López Álvarez, L.A., Lorrey, A.M., Loyola, D., Lumpkin, R., Luo, J.-J., Luojus, K., Lydersen, C., Lyman, J.M., Maberly, S.C., Maddux, B.C., Malheiros Ramos, A., Malkova, G.V., Manney, G., Marcellin, V., Marchenko, S.S., Marengo, J.A., Marra, J.J., Marszelewski, W., Martens, B., Martínez-Güingla, R., Massom, R.A., Mata, M.M., Mathis, J.T., May, L., Mayer, M., Mazloff, M., McBride, C., McCabe, M.F., McCarthy, M., McClelland, J.W., McGree, S., McVicar, T.R., Mears, C.A., Meier, W., Meinen, C.S., Mekonnen, A., Menéndez, M., Mengistu Tsidu, G., Menzel, W.P., Merchant, C.J., Meredith, M.P., Merrifield, M.A., Metzl, N., Minnis, P., Miralles, D.G., Mistelbauer, T., Mitchum, G.T., Monselesan, D., Monteiro, P., Montzka, S.A., Morice, C., Mote, T., Mudryk, L., Mühle, J., Mullan, A.B., Nash, E.R., Naveira-Garabato, A.C., Nerem, R.S., Newman, P.A., Nieto, J.J., Noetzli, J., O’Neel, S., Osborn, T.J., Overland, J., Oyunjargal, L., Parinussa, R.M., Park, E.-H., Parker, D., Parrington, M., Parsons, A.R., Pasch, R.J., Pascual-Ramírez, R., Paterson, A.M., Paulik, C., Pearce, P.R., Pelto, M.S., Peng, L., Perkins-Kirkpatrick, S.E., Perovich, D., Petropavlovskikh, I., Pezza, A.B., Phillips, D., Pinty, B., Pitts, M.C., Pons, M.R., Porter, A.O., Primicerio, R., Proshutinsky, A., Quegan, S., Quintana, J., Rahimzadeh, F., Rajeevan, M., Randriamarolaza, L., Razuvaev, V.N., Reagan, J., Reid, P., Reimer, C., Rémy, S., Renwick, J.A., Revadekar, J.V., Richter-Menge, J., Riffler, M., Rimmer, A., Rintoul, S., Robinson, D.A., Rodell, M., Rodríguez Solís, J.L., Romanovsky, V.E., Ronchail, J., Rosenlof, K.H., Roth, C., Rusak, J.A., Sabine, C.L., Sallée, J.-B., Sánchez-Lugo, A., Santee, M.L., Sawaengphokhai, P., Sayouri, A., Scambos, T.A., Schemm, J., Schladow, S.G., Schmid, C., Schmid, M., Schmidtko, S., Schreck, C.J., Selkirk, H.B., Send, U., Sensoy, S., Setzer, A., Sharp, M., Shaw, A., Shi, L., Shiklomanov, A.I., Shiklomanov, N.I., Siegel, D.A., Signorini, S.R., Sima, F., Simmons, A.J., Smeets, C.J.P.P., Smith, S.L., Spence, J.M., Srivastava, A.K., Stackhouse, P.W., Stammerjohn, S., Steinbrecht, W., Stella, J.L., Stengel, M., Stennett-Brown, R., Stephenson, T.S., Strahan, S., Streletskiy, D.A., Sun-Mack, S., Swart, S., Sweet, W., Talley, L.D., Tamar, G., Tank, S.E., Taylor, M.A., Tedesco, M., Teubner, K., Thoman, R.L., Thompson, P., Thomson, L., Timmermans, M.-L., Tirnanes, J.A., Tobin, S., Trachte, K., Trainer, V.L., Tretiakov, M., Trewin, B.C., Trotman, A.R., Tschudi, M., Van As, D., Van De Wal, R.S.W., van der A., R.J., Van Der Schalie, R., Van Der Schrier, G., Van Der Werf, G.R., Van Meerbeeck, C.J., Velicogna, I., Verburg, P., Vigneswaran, B., Vincent, L.A., Volkov, D., Vose, R.S., Wagner, W., Wåhlin, A., Wahr, J., Walsh, J., Wang, C., Wang, J., Wang, L., Wang, M., Wang, S.-H., Wanninkhof, R., Watanabe, S., Weber, M., Weller, R.A., Weyhenmeyer, G.A., Whitewood, R., Wijffels, S.E., Wilber, A.C., Wild, J.D., Willett, K.M., Williams, M.J.M., Willie, S., Wolken, G., Wong, T., Wood, E.F., Woolway, R.I., Wouters, B., Xue, Y., Yamada, R., Yim, S.-Y., Yin, X., Young, S.H., Yu, L., Zahid, H., Zambrano, E., Zhang, P., Zhao, G., Zhou, L., Ziemke, J.R., Love-Brotak, S.E., Gilbert, K., Maycock, T., Osborne, S., Sprain, M., Veasey, S.W., Ambrose, B.J., Griffin, J., Misch, D.J., Riddle, D.B., and Young, T.

Published
2016

289. Safety, tolerability and pharmacokinetic properties of coadministered azithromycin and piperaquine in pregnant Papua New Guinean women

Author

Moore, B., Benjamin, J., Auyeung, S., Salman, S., Yadi, G., Griffin, S., Page-Sharp, M., Batty, Kevin, Siba, P., Mueller, I., Rogerson, S., Davis, T., Moore, B., Benjamin, J., Auyeung, S., Salman, S., Yadi, G., Griffin, S., Page-Sharp, M., Batty, Kevin, Siba, P., Mueller, I., Rogerson, S., and Davis, T.

Abstract

Aims: The aim of the present study was to investigate the safety, tolerability and pharmacokinetics of coadministered azithromycin (AZI) and piperaquine (PQ) for treating malaria in pregnant Papua New Guinean women. Methods: Thirty pregnant women (median age 22 years; 16-32 weeks' gestation) were given three daily doses of 1 g AZI plus 960 mg PQ tetraphosphate with detailed monitoring/blood sampling over 42 days. Plasma AZI and PQ were assayed using liquid chromatography-mass spectrometry and high-performance liquid chromatography, respectively. Pharmacokinetic analysis was by population-based compartmental models. Results: The treatment was well tolerated. The median (interquartile range) increase in the rate-corrected electrocardiographic QT interval 4 h postdose [12 (6-26) ms0 .5] was similar to that found in previous studies of AZI given in pregnancy with other partner drugs. Six women with asymptomatic malaria cleared their parasitaemias within 72 h. Two apararasitaemic women developed late uncomplicated Plasmodium falciparum infections on Days 42 and 83. Compared with previous pregnancy studies, the area under the concentration-time curve (AUC0-8) for PQ [38818 (24354-52299) µg h l-1] was similar to published values but there was a 52% increase in relative bioavailability with each dose. The AUC0-8 for AZI [46799 (43526-49462) µg h l-1] was at least as high as reported for higher-dose regimens, suggesting saturable absorption and/or concentration-dependent tissue uptake and clearance from the central compartment. Conclusions: AZI-PQ appears to be well tolerated and safe in pregnancy. Based on the present/other data, total AZI doses higher than 3 g for the treatment and prevention of malaria may be unnecessary in pregnant women, while clearance of parasitaemia could improve the relative bioavailability of PQ.

Published
2016

291. HEAT PIPE AUGMENTED PASSIVE SOLAR SYSTEM FOR HEATING OF BUILDINGS

Author

Susheela, Narasimhan and Sharp, M. Keith

Subjects
Solar heating -- Passive systems, Heat pipes -- Usage, Engineering and manufacturing industries, Science and technology
Abstract

A passive solar heating system was built using heat pipes bonded to the absorbing surface of a solar collector mounted on the south wall of a building. The heat pipes provided one-way heat transfer from the absorber through the insulated wall of the building to water tanks placed inside the space to be heated. The space was then heated by means of natural convection from the surfaces of the tank. The evaporator and condenser ends of the heat pipe were designed to be connected by means of a flexible hose so that the system could be retrofit to an existing building. Simulations were carried out to match the experimental and simulated results. The conductance values obtained as a result of matching showed good agreement with theoretically calculated values. Potential performance improvements were identified, including increased liquid fill fraction in the heat pipes and increasing the heat transfer surface area of the water tanks at the condenser end of the pipe.

Published
2001

292. Stability of Elliptical Cylinders in Two-Dimensional Channel Flow

Author

Zhao, Yu and Sharp, M. Keith

Subjects
Blood flow -- Measurement, Erythrocytes -- Research, Fluid dynamics -- Research, Blood -- Rheology, Engineering and manufacturing industries, Science and technology
Abstract

The flow around rigid cylinders of elliptical cross section placed transverse to Poiseuille flow between parallel plates was simulated to investigate issues related to the tumbling of red blood cells and other particles of moderate aspect ratio in the similar flow in a Field Flow Fractionation (FFF) channel. The torque and transverse force on the cylinder were calculated with the cylinder freely translating, but prevented from rotating, in the flow. The aspect ratios (long axis to short axis) of the elliptical cylinders were 2, 3, 4, and 5. The cylinder was placed transversely at locations of [y.sub.0]/H = 0.1, 0.2, 0.3, and 0.4, where [y.sub.0] is the distance from the bottom of the channel and H is the height of the channel, and the orientation of the cylinder was varied from 0 to 10 deg with respect to the axis of the channel for a channel Reynolds number of 20. The results showed that equilibrium orientations (indicated by a zero net torque on the cylinder) were possible for high-aspectratio cylinders at transverse locations [y.sub.0]/H [is less than] 0.2. Otherwise, the net torque on the cylinder was positive, indicating that the cylinder would rotate. For cylinders with a stable orientation, however, a transverse lift force existed up to about [y.sub.0]/H=0.25. Thus, a cylinder of neutral or low buoyancy might be lifted with a stable orientation from an initial position near the wall until it reached [y.sub.0]/H [is less than] 0.2, whereupon it would begin to tumble or oscillate. The dependence of lift and torque on cylinder orientation suggested that neutral or low-buoyancy cylinders may oscillate in both transverse location and angular velocity. Cylinders more dense than the carrier fluid could be in equilibrium both in terms of orientation and transverse location if their sedimentation force matched their lift force for a location [y.sub.0]/H [is less than] 0.2. [S0148-0731(00)00505-7]

Published
2000

294. Glacier velocities and dynamic ice discharge from the Queen Elizabeth Islands, Nunavut, Canada

Author

Van Wychen, W, Burgess, DO, Gray, L, Copland, L, Sharp, M, Dowdeswell, JA, Benham, TJ, Dowdeswell, Julian [0000-0003-1369-9482], Benham, Toby [0000-0003-2723-1880], and Apollo - University of Cambridge Repository

Subjects
glacier dynamics, speckle tracking, dynamic ice discharge
Abstract

Recent studies indicate an increase in glacier mass loss from the Canadian Arctic Archipelago as a result of warmer summer air temperatures. However, no complete assessment of dynamic ice discharge from this region exists. We present the first complete surface velocity mapping of all ice masses in the Queen Elizabeth Islands and show that these ice masses discharged ~2.6 ± 0.8 Gt a−1 of ice to the oceans in winter 2012. Approximately 50% of the dynamic discharge was channeled through non surge-type Trinity and Wykeham Glaciers alone. Dynamic discharge of the surge-type Mittie Glacier varied from 0.90 ± 0.09 Gt a−1 during its 2003 surge to 0.02 ± 0.02 Gt a−1 during quiescence in 2012, highlighting the importance of surge-type glaciers for interannual variability in regional mass loss. Queen Elizabeth Islands glaciers currently account for ~7.5% of reported dynamic discharge from Arctic ice masses outside Greenland.

Published
2014

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