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251. Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma

Author: Stepien, Magdalena Lopez-Nogueroles, Marina Lahoz, Agustin and Kuehn, Tilman Perlemuter, Gabriel Voican, Cosmin Ciocan, Dragos Boutron-Ruault, Marie-Christine Jansen, Eugene and Viallon, Vivian Leitzmann, Michael Tjonneland, Anne Severi, Gianluca Mancini, Francesca Romana Dong, Catherine Kaaks, Rudolf Fortner, Renee Turzanski Bergmann, Manuela M. Boeing, Heiner Trichopoulou, Antonia Karakatsani, Anna Peppa, Eleni and Palli, Domenico Krogh, Vittorio Tumino, Rosario and Sacerdote, Carlotta Panico, Salvatore Bueno-de-Mesquita, H. Bas and Skeie, Guri Merino, Susana Ros, Raul Zamora Sanchez, Maria Jose Amiano, Pilar Huerta, Jose Ma Barricarte, Aurelio and Sjoeberg, Klas Ohlsson, Bodil Nystroem, Hanna Werner, Marten Perez-Cornago, Aurora Schmidt, Julie A. Freisling, Heinz Scalbert, Augustin Weiderpass, Elisabete Christakoudi, Sofia Gunter, Marc J. Jenab, Mazda
Subjects: education
Abstract: Bile acids (BAs) play different roles in cancer development. Some are carcinogenic and BA signaling is also involved in various metabolic, inflammatory and immune-related processes. The liver is the primary site of BA synthesis. Liver dysfunction and microbiome compositional changes, such as during hepatocellular carcinoma (HCC) development, may modulate BA metabolism increasing concentration of carcinogenic BAs. Observations from prospective cohorts are sparse. We conducted a study (233 HCC case-control pairs) nested within a large observational prospective cohort with blood samples taken at recruitment when healthy with follow-up over time for later cancer development. A targeted metabolomics method was used to quantify 17 BAs (primary/secondary/tertiary; conjugated/unconjugated) in prediagnostic plasma. Odd ratios (OR) for HCC risk associations were calculated by multivariable conditional logistic regression models. Positive HCC risk associations were observed for the molar sum of all BAs (ORdoubling = 2.30, 95% confidence intervals [CI]: 1.76-3.00), and choline- and taurine-conjugated BAs. Relative concentrations of BAs showed positive HCC risk associations for glycoholic acid and most taurine-conjugated BAs. We observe an association between increased HCC risk and higher levels of major circulating BAs, from several years prior to tumor diagnosis and after multivariable adjustment for confounders and liver functionality. Increase in BA concentration is accompanied by a shift in BA profile toward higher proportions of taurine-conjugated BAs, indicating early alterations of BA metabolism with HCC development. Future studies are needed to assess BA profiles for improved stratification of patients at high HCC risk and to determine whether supplementation with certain BAs may ameliorate liver dysfunction.
Published: 2022

252. Additional file 1 of Pre-diagnostic C-reactive protein concentrations, CRP genetic variation and mortality among individuals with colorectal cancer in Western European populations

Author: Nimptsch, Katharina, Aleksandrova, Krasimira, Fedirko, Veronika, Jenab, Mazda, Gunter, Marc J., Siersema, Peter D., Wu, Kana, Katzke, Verena, Kaaks, Rudolf, Panico, Salvatore, Palli, Domenico, May, Anne M, Sieri, Sabina, Bueno-de-Mesquita, Bas, Standahl, Karina, Sánchez, Maria-Jose, Perez-Cornago, Aurora, Olsen, Anja, Tjønneland, Anne, Bonet, Catalina Bonet, Dahm, Christina C., Chirlaque, María-Dolores, Fiano, Valentina, Tumino, Rosario, Gurrea, Aurelio Barricarte, Boutron-Ruault, Marie-Christine, Menegaux, Florence, Severi, Gianluca, van Guelpen, Bethany, Lee, Young-Ae, and Pischon, Tobias
Subjects: Data_FILES
Abstract: Additional file 1.
Published: 2022
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253. Long-term Air Pollution Exposure and Pneumonia Related Mortality in a Large Pooled European Cohort

Author: Liu, Shuo Lim, Youn-Hee Chen, Jie Strak, Maciek Wolf, Kathrin Weinmayr, Gudrun Rodopolou, Sophia de Hoogh, Kees Bellander, Tom Brandt, Jørgen Concin, Hans Zitt, Emanuel Fecht, Daniela Forastiere, Francesco Gulliver, John Hertel, Ole Hoffmann, Barbara Hvidtfeldt, Ulla A. Verschuren, W. M. Monique Jöckel, Karl-Heinz Jørgensen, Jeanette T. So, Rina Amini, Heresh Cole-Hunter, Thomas Mehta, Amar J. Mortensen, Laust H. Ketzel, Matthias Lager, Anton Leander, Karin Ljungman, Petter Severi, Gianluca Boutron-Ruault, Marie-Christine Magnusson, Patrik K. E. Nagel, Gabriele Pershagen, Göran Peters, Annette Raaschou-Nielsen, Ole Rizzuto, Debora van der Schouw, Yvonne T. Schramm, Sara Sørensen, Mette Stafoggia, Massimo Tjønneland, Anne Katsouyanni, Klea Huang, Wei Samoli, Evangelia Brunekreef, Bert Hoek, Gerard Andersen, Zorana J.
Abstract: RATIONALE: Ambient air pollution exposure has been linked to mortality from chronic cardiorespiratory diseases, while evidence on respiratory infections remains more limited. OBJECTIVES: We examined the association between long-term exposure to air pollution and pneumonia related mortality in adults in a pool of eight European cohorts. METHODS: Within the multicenter project ’Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from eight cohorts among six European countries. Annual mean residential concentrations in 2010 for fine particulate matter (PM(2.5)), nitrogen dioxide (NO(2)), black carbon (BC), and ozone (O(3)) were estimated using Europe-wide hybrid land use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and pneumonia, influenza, and acute lower respiratory infections (ALRI) mortality. MEASUREMENTS AND MAIN RESULTS: Of 325,367 participants, 712 died from pneumonia and influenza combined, 682 from pneumonia, and 695 from ALRI during a mean follow-up of 19.5 years. NO(2) and BC were associated with 10-12% increases in pneumonia and influenza combined mortality, but 95% confidence intervals included unity [hazard ratios: 1.12 (0.99-1.26) per 10 µg/m(3) for NO(2); 1.10 (0.97-1.24) per 0.5 10(-5)m(-1) for BC]. Associations with pneumonia and ALRI mortality were almost identical. We detected effect modification suggesting stronger associations with NO(2) or BC in overweight, employed, or currently smoking participants compared to normal weight, unemployed, or non-smoking participants. CONCLUSIONS: Long-term exposure to combustion-related air pollutants NO(2) and BC may be associated with mortality from lower respiratory infections, but larger studies are needed to estimate these associations more precisely.
Published: 2022

254. Additional file 1 of Application of two statistical approaches (Bayesian Kernel Machine Regression and Principal Component Regression) to assess breast cancer risk in association to exposure to mixtures of brominated flame retardants and per- and polyfluorinated alkylated substances in the E3N cohort

Author: Frenoy, Pauline, Perduca, Vittorio, Cano-Sancho, German, Antignac, Jean-Philippe, Severi, Gianluca, and Mancini, Francesca Romana
Abstract: Additional file 1: Table S1. Percentage of values below the Limit Of Detection (LOD) and associated decision for each substance measured in the present study. Table S2. Loading factors for each substances on each of the 4 components obtained by principal component analysis. Table S3. Associations between adherence to PCA components and all breast cancer risk. Components are used in continuous and in quintiles in conditionnal logistic regression models. Odds Ratio (OR) and 95% Confidence Intervals (CI) are presented. Figure S1. Correlation matrix between log-transformed exposure to substances in the study population. Pearson��s rank correlation coefficients are presented. Figure S2-A. Conditional posterior inclusion probabilities of substances within group for all breast cancer risk. Figure S2-B. Conditional posterior inclusion probabilities of substances within group for ER+ breast cancer risk. Figure S2-C. Conditional posterior inclusion probabilities of substances within group for ER- breast cancer risk. Figure S3. Exposure-response functions between exposure to Substance 1 and probit of probability of having a breast cancer while Substance 2 is fixed at defined percentiles (20th, 50th, and 80th), all other substances being fixed at their median value. Figure S4. Cumulative effect of PFAS, PBB and PBDE for all breast cancer risk.
Published: 2022
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255. Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Author: Sampson, Joshua N., Wheeler, William A., Yeager, Meredith, Panagiotou, Orestis, Wang, Zhaoming, Berndt, Sonja I., Lan, Qing, Abnet, Christian C., Amundadottir, Laufey T., Figueroa, Jonine D., Landi, Maria Teresa, Mirabello, Lisa, Savage, Sharon A., Taylor, Philip R., Vivo, Immaculata De, McGlynn, Katherine A., Purdue, Mark P., Rajaraman, Preetha, Adami, Hans-Olov, Ahlbom, Anders, Albanes, Demetrius, Amary, Maria Fernanda, An, She-Juan, Andersson, Ulrika, Andriole, Gerald, Jr., Andrulis, Irene L., Angelucci, Emanuele, Ansell, Stephen M., Arici, Cecilia, Armstrong, Bruce K., Arslan, Alan A., Austin, Melissa A., Baris, Dalsu, Barkauskas, Donald A., Bassig, Bryan A., Becker, Nikolaus, Benavente, Yolanda, Benhamou, Simone, Berg, Christine, Van Den Berg, David, Bernstein, Leslie, Bertrand, Kimberly A., Birmann, Brenda M., Black, Amanda, Boeing, Heiner, Boffetta, Paolo, Boutron-Ruault, Marie-Christine, Bracci, Paige M., Brinton, Louise, Brooks-Wilson, Angela R., Bueno-de-Mesquita, H. Bas, Burdett, Laurie, Buring, Julie, Butler, Mary Ann, Cai, Qiuyin, Cancel-Tassin, Geraldine, Canzian, Federico, Carrato, Alfredo, Carreon, Tania, Carta, Angela, Chan, John K. C., Chang, Ellen T., Chang, Gee-Chen, Chang, I-Shou, Chang, Jiang, Chang-Claude, Jenny, Chen, Chien-Jen, Chen, Chih-Yi, Chen, Chu, Chen, Chung-Hsing, Chen, Constance, Chen, Hongyan, Chen, Kexin, Chen, Kuan-Yu, Chen, Kun-Chieh, Chen, Ying, Chen, Ying-Hsiang, Chen, Yi-Song, Chen, Yuh-Min, Chien, Li-Hsin, Chirlaque, María-Dolores, Choi, Jin Eun, Choi, Yi Young, Chow, Wong-Ho, Chung, Charles C., Clavel, Jacqueline, Clavel-Chapelon, Françoise, Cocco, Pierluigi, Colt, Joanne S., Comperat, Eva, Conde, Lucia, Connors, Joseph M., Conti, David, Cortessis, Victoria K., Cotterchio, Michelle, Cozen, Wendy, Crouch, Simon, Crous-Bou, Marta, Cussenot, Olivier, Davis, Faith G., Ding, Ti, Diver, W. Ryan, Dorronsoro, Miren, Dossus, Laure, Duell, Eric J., Ennas, Maria Grazia, Erickson, Ralph L., Feychting, Maria, Flanagan, Adrienne M., Foretova, Lenka, Fraumeni, Joseph F., Jr, Freedman, Neal D., Beane Freeman, Laura E., Fuchs, Charles, Gago-Dominguez, Manuela, Gallinger, Steven, Gao, Yu-Tang, Gapstur, Susan M., Garcia-Closas, Montserrat, García-Closas, Reina, Gascoyne, Randy D., Gastier-Foster, Julie, Gaudet, Mia M., Gaziano, J. Michael, Giffen, Carol, Giles, Graham G., Giovannucci, Edward, Glimelius, Bengt, Goggins, Michael, Gokgoz, Nalan, Goldstein, Alisa M., Gorlick, Richard, Gross, Myron, Grubb, Robert, III, Gu, Jian, Guan, Peng, Gunter, Marc, Guo, Huan, Habermann, Thomas M., Haiman, Christopher A., Halai, Dina, Hallmans, Goran, Hassan, Manal, Hattinger, Claudia, He, Qincheng, He, Xingzhou, Helzlsouer, Kathy, Henderson, Brian, Henriksson, Roger, Hjalgrim, Henrik, Hoffman-Bolton, Judith, Hohensee, Chancellor, Holford, Theodore R., Holly, Elizabeth A., Hong, Yun-Chul, Hoover, Robert N., Horn-Ross, Pamela L., Hosain, G. M. Monawar, Hosgood, H. Dean, III, Hsiao, Chin-Fu, Hu, Nan, Hu, Wei, Hu, Zhibin, Huang, Ming-Shyan, Huerta, Jose-Maria, Hung, Jen-Yu, Hutchinson, Amy, Inskip, Peter D., Jackson, Rebecca D., Jacobs, Eric J., Jenab, Mazda, Jeon, Hyo-Sung, Ji, Bu-Tian, Jin, Guangfu, Jin, Li, Johansen, Christoffer, Johnson, Alison, Jung, Yoo Jin, Kaaks, Rudolph, Kamineni, Aruna, Kane, Eleanor, Kang, Chang Hyun, Karagas, Margaret R., Kelly, Rachel S., Khaw, Kay-Tee, Kim, Christopher, Kim, Hee Nam, Kim, Jin Hee, Kim, Jun Suk, Kim, Yeul Hong, Kim, Young Tae, Kim, Young-Chul, Kitahara, Cari M., Klein, Alison P., Klein, Robert J., Kogevinas, Manolis, Kohno, Takashi, Kolonel, Laurence N., Kooperberg, Charles, Kricker, Anne, Krogh, Vittorio, Kunitoh, Hideo, Kurtz, Robert C., Kweon, Sun-Seog, LaCroix, Andrea, Lawrence, Charles, Lecanda, Fernando, Lee, Victor Ho Fun, Li, Donghui, Li, Haixin, Li, Jihua, Li, Yao-Jen, Li, Yuqing, Liao, Linda M., Liebow, Mark, Lightfoot, Tracy, Lim, Wei-Yen, Lin, Chien-Chung, Lin, Dongxin, Lindstrom, Sara, Linet, Martha S., Link, Brian K., Liu, Chenwei, Liu, Jianjun, Liu, Li, Ljungberg, Börje, Lloreta, Josep, Lollo, Simonetta Di, Lu, Daru, Lund, Eiluv, Malats, Nuria, Mannisto, Satu, Marchand, Loic Le, Marina, Neyssa, Masala, Giovanna, Mastrangelo, Giuseppe, Matsuo, Keitaro, Maynadie, Marc, McKay, James, McKean-Cowdin, Roberta, Melbye, Mads, Melin, Beatrice S., Michaud, Dominique S., Mitsudomi, Tetsuya, Monnereau, Alain, Montalvan, Rebecca, Moore, Lee E., Mortensen, Lotte Maxild, Nieters, Alexandra, North, Kari E., Novak, Anne J., Oberg, Ann L., Offit, Kenneth, Oh, In-Jae, Olson, Sara H., Palli, Domenico, Pao, William, Park, In Kyu, Park, Jae Yong, Park, Kyong Hwa, Patiño-Garcia, Ana, Pavanello, Sofia, Peeters, Petra H. M., Perng, Reury-Perng, Peters, Ulrike, Petersen, Gloria M., Picci, Piero, Pike, Malcolm C., Porru, Stefano, Prescott, Jennifer, Prokunina-Olsson, Ludmila, Qian, Biyun, Qiao, You-Lin, Rais, Marco, Riboli, Elio, Riby, Jacques, Risch, Harvey A., Rizzato, Cosmeri, Rodabough, Rebecca, Roman, Eve, Roupret, Morgan, Ruder, Avima M., Sanjose, Silvia de, Scelo, Ghislaine, Schned, Alan, Schumacher, Fredrick, Schwartz, Kendra, Schwenn, Molly, Scotlandi, Katia, Seow, Adeline, Serra, Consol, Serra, Massimo, Sesso, Howard D., Setiawan, Veronica Wendy, Severi, Gianluca, Severson, Richard K., Shanafelt, Tait D., Shen, Hongbing, Shen, Wei, Shin, Min-Ho, Shiraishi, Kouya, Shu, Xiao-Ou, Siddiq, Afshan, Sierrasesúmaga, Luis, Sihoe, Alan Dart Loon, Skibola, Christine F., Smith, Alex, Smith, Martyn T., Southey, Melissa C., Spinelli, John J., Staines, Anthony, Stampfer, Meir, Stern, Marianna C., Stevens, Victoria L., Stolzenberg-Solomon, Rachael S., Su, Jian, Su, Wu-Chou, Sund, Malin, Sung, Jae Sook, Sung, Sook Whan, Tan, Wen, Tang, Wei, Tardón, Adonina, Thomas, David, Thompson, Carrie A., Tinker, Lesley F., Tirabosco, Roberto, Tjønneland, Anne, Travis, Ruth C., Trichopoulos, Dimitrios, Tsai, Fang-Yu, Tsai, Ying-Huang, Tucker, Margaret, Turner, Jenny, Vajdic, Claire M., Vermeulen, Roel C. H., Villano, Danylo J., Vineis, Paolo, Virtamo, Jarmo, Visvanathan, Kala, Wactawski-Wende, Jean, Wang, Chaoyu, Wang, Chih-Liang, Wang, Jiu-Cun, Wang, Junwen, Wei, Fusheng, Weiderpass, Elisabete, Weiner, George J., Weinstein, Stephanie, Wentzensen, Nicolas, White, Emily, Witzig, Thomas E., Wolpin, Brian M., Wong, Maria Pik, Wu, Chen, Wu, Guoping, Wu, Junjie, Wu, Tangchun, Wu, Wei, Wu, Xifeng, Wu, Yi-Long, Wunder, Jay S., Xiang, Yong-Bing, Xu, Jun, Xu, Ping, Yang, Pan-Chyr, Yang, Tsung-Ying, Ye, Yuanqing, Yin, Zhihua, Yokota, Jun, Yoon, Ho-Il, Yu, Chong-Jen, Yu, Herbert, Yu, Kai, Yuan, Jian-Min, Zelenetz, Andrew, Zeleniuch-Jacquotte, Anne, Zhang, Xu-Chao, Zhang, Yawei, Zhao, Xueying, Zhao, Zhenhong, Zheng, Hong, Zheng, Tongzhang, Zheng, Wei, Zhou, Baosen, Zhu, Meng, Zucca, Mariagrazia, Boca, Simina M., Cerhan, James R., Ferri, Giovanni M., Hartge, Patricia, Hsiung, Chao Agnes, Magnani, Corrado, Miligi, Lucia, Morton, Lindsay M., Smedby, Karin E., Teras, Lauren R., Vijai, Joseph, Wang, Sophia S., Brennan, Paul, Caporaso, Neil E., Hunter, David J., Kraft, Peter, Rothman, Nathaniel, Silverman, Debra T., Slager, Susan L., Chanock, Stephen J., and Chatterjee, Nilanjan
Published: 2015
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256. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study

Author: Duell, Eric J., Lujan-Barroso, Leila, Sala, Núria, McElyea, Samantha Deitz, Overvad, Kim, Tjonneland, Anne, Olsen, Anja, Weiderpass, Elisabete, Busund, Lill-Tove, Moi, Line, Muller, David, Vineis, Paolo, Aune, Dagfinn, Matullo, Giuseppe, Naccarati, Alessio, Panico, Salvatore, Tagliabue, Giovanna, Tumino, Rosario, Palli, Domenico, Kaaks, Rudolf, Katzke, Verena A., Boeing, Heiner, Bueno-de-Mesquita, B(as) H., Peeters, Petra H., Trichopoulou, Antonia, Lagiou, Pagona, Kotanidou, Anastasia, Travis, Ruth C., Wareham, Nick, Khaw, Kay-Tee, Quiros, Jose Ramon, Rodríguez-Barranco, Miguel, Dorronsoro, Miren, Chirlaque, María-Dolores, Ardanaz, Eva, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Rebours, Vinciane, Brennan, Paul, Gunter, Marc, Scelo, Ghislaine, Cote, Greg, Sherman, Stuart, and Korc, Murray
Published: 2017
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257. Endometrial cancer risk prediction including serum‐based biomarkers: results from the EPIC cohort

Author: Fortner, Renée T., Hüsing, Anika, Kühn, Tilman, Konar, Meric, Overvad, Kim, Tjønneland, Anne, Hansen, Louise, BoutronRuault, MarieChristine, Severi, Gianluca, Fournier, Agnès, Boeing, Heiner, Trichopoulou, Antonia, Benetou, Vasiliki, Orfanos, Philippos, Masala, Giovanna, Agnoli, Claudia, Mattiello, Amalia, Tumino, Rosario, Sacerdote, Carlotta, BuenodeMesquita, H.B(as), Peeters, Petra H.M., Weiderpass, Elisabete, Gram, Inger T., Gavrilyuk, Oxana, Quirós, J. Ramón, Maria Huerta, José, Ardanaz, Eva, Larrañaga, Nerea, LujanBarroso, Leila, SánchezCantalejo, Emilio, Butt, Salma Tunå, Borgquist, Signe, Idahl, Annika, Lundin, Eva, Khaw, KayTee, Allen, Naomi E., Rinaldi, Sabina, Dossus, Laure, Gunter, Marc, Merritt, Melissa A., Tzoulaki, Ioanna, Riboli, Elio, and Kaaks, Rudolf
Published: 2017
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258. Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies

Author: Brenner, Darren R., Fanidi, Anouar, Grankvist, Kjell, Muller, David C., Brennan, Paul, Manjer, Jonas, Byrnes, Graham, Hodge, Allison, Severi, Gianluca, Giles, Graham G., Johansson, Mikael, and Johansson, Mattias
Published: 2017
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259. The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study

Author: Johansson, Mattias, Carreras-Torres, Robert, Scelo, Ghislaine, Purdue, Mark P., Mariosa, Daniela, Muller, David C., Timpson, Nicolas J., Haycock, Philip C., Brown, Kevin M., Wang, Zhaoming, Ye, Yuanqing, Hofmann, Jonathan N., Foll, Matthieu, Gaborieau, Valerie, Machiela, Mitchell J., Colli, Leandro M., Li, Peng, Garnier, Jean-Guillaume, Blanche, Helene, Boland, Anne, Burdette, Laurie, Prokhortchouk, Egor, Skryabin, Konstantin G., Yeager, Meredith, Radojevic-Skodric, Sanja, Ognjanovic, Simona, Foretova, Lenka, Holcatova, Ivana, Janout, Vladimir, Mates, Dana, Mukeriya, Anush, Rascu, Stefan, Zaridze, David, Bencko, Vladimir, Cybulski, Cezary, Fabianova, Eleonora, Jinga, Viorel, Lissowska, Jolanta, Lubinski, Jan, Navratilova, Marie, Rudnai, Peter, Benhamou, Simone, Cancel-Tassin, Geraldine, Cussenot, Olivier, Weiderpass, Elisabete, Ljungberg, Börje, Tumkur Sitaram, Raviprakash, Häggström, Christel, Bruinsma, Fiona, Jordan, Susan J., Severi, Gianluca, Winship, Ingrid, Hveem, Kristian, Vatten, Lars J., Fletcher, Tony, Larsson, Susanna C., Wolk, Alicja, Banks, Rosamonde E., Selby, Peter J., Easton, Douglas F., Andreotti, Gabriella, Beane Freeman, Laura E., Koutros, Stella, Männistö, Satu, Weinstein, Stephanie, Clark, Peter E., Edwards, Todd L., Lipworth, Loren, Gapstur, Susan M., Stevens, Victoria L., Carol, Hallie, Freedman, Matthew L., Pomerantz, Mark M., Cho, Eunyoung, Wilson, Kathryn M., Gaziano, J. Michael, Sesso, Howard D., Freedman, Neal D., Parker, Alexander S., Eckel-Passow, Jeanette E., Huang, Wen-Yi, Kahnoski, Richard J., Lane, Brian R., Noyes, Sabrina L., Petillo, David, Teh, Bin Tean, Peters, Ulrike, White, Emily, Anderson, Garnet L., Johnson, Lisa, Luo, Juhua, Buring, Julie, Lee, I-Min, Chow, Wong-Ho, Moore, Lee E., Eisen, Timothy, Henrion, Marc, Larkin, James, Barman, Poulami, Leibovich, Bradley C., Choueiri, Toni K., Lathrop, G. Mark, Deleuze, Jean-Francois, Gunter, Marc, McKay, James D., Wu, Xifeng, Houlston, Richard S., Chanock, Stephen J., Relton, Caroline, Richards, J. Brent, Martin, Richard M., Davey Smith, George, and Brennan, Paul
Subjects: Obesity -- Genetic aspects -- Complications and side effects, Renal cell carcinoma -- Genetic aspects -- Development and progression -- Care and treatment, Genetic markers -- Health aspects, Etiology (Medicine), Genetics, Carcinoma, Cancer, Type 2 diabetes, Genomics, Insulin, Proxy, Lipids, Genomes, Fasting, Glucose, Biological sciences
Abstract: Background Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies for putative risk factors and evaluated their relation to RCC risk in a mendelian randomization (MR) framework. This methodology limits bias due to confounding and is not affected by reverse causation. Methods and findings Genetic markers associated with obesity measures, blood pressure, lipids, type 2 diabetes, insulin, and glucose were initially identified as instrumental variables, and their association with RCC risk was subsequently evaluated in a genome-wide association study (GWAS) of 10,784 RCC patients and 20,406 control participants in a 2-sample MR framework. The effect on RCC risk was estimated by calculating odds ratios (OR.sub.SD) for a standard deviation (SD) increment in each risk factor. The MR analysis indicated that higher body mass index increases the risk of RCC (OR.sub.SD : 1.56, 95% confidence interval [CI] 1.44-1.70), with comparable results for waist-to-hip ratio (OR.sub.SD : 1.63, 95% CI 1.40-1.90) and body fat percentage (OR.sub.SD : 1.66, 95% CI 1.44-1.90). This analysis further indicated that higher fasting insulin (OR.sub.SD : 1.82, 95% CI 1.30-2.55) and diastolic blood pressure (DBP; OR.sub.SD : 1.28, 95% CI 1.11-1.47), but not systolic blood pressure (OR.sub.SD : 0.98, 95% CI 0.84-1.14), increase the risk for RCC. No association with RCC risk was seen for lipids, overall type 2 diabetes, or fasting glucose. Conclusions This study provides novel evidence for an etiological role of insulin in RCC, as well as confirmatory evidence that obesity and DBP influence RCC risk., Author(s): Mattias Johansson 1,*, Robert Carreras-Torres 1, Ghislaine Scelo 1, Mark P. Purdue 2, Daniela Mariosa 1, David C. Muller 3, Nicolas J. Timpson 4, Philip C. Haycock 4, Kevin [...]
Published: 2019
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260. Prediagnosis biomarkers of insulin-like growth factor-1, insulin, and interleukin-6 dysregulation and multiple myeloma risk in the Multiple Myeloma Cohort Consortium

Author: Birmann, Brenda M., Neuhouser, Marian L., Rosner, Bernard, Albanes, Demetrius, Buring, Julie E., Giles, Graham G., Lan, Qing, Lee, I-Min, Purdue, Mark P., Rothman, Nathaniel, Severi, Gianluca, Yuan, Jian-Min, Anderson, Kenneth C., Pollak, Michael, Rifai, Nader, Hartge, Patricia, Landgren, Ola, Lessin, Lawrence, Virtamo, Jarmo, Wallace, Robert B., Manson, JoAnn E., and Colditz, Graham A.
Published: 2012
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261. Baseline and lifetime alcohol consumption and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC).

Author: Mahamat‐Saleh, Yahya, Al‐Rahmoun, Marie, Severi, Gianluca, Ghiasvand, Reza, Veierod, Marit B., Caini, Saverio, Palli, Domenico, Botteri, Edoardo, Sacerdote, Carlotta, Ricceri, Fulvio, Lukic, Marko, Sánchez, Maria J., Pala, Valeria, Tumino, Rosario, Chiodini, Paolo, Amiano, Pilar, Colorado‐Yohar, Sandra, Chirlaque, María‐Dolores, Ardanaz, Eva, and Bonet, Catalina
Subjects: SKIN cancer, ALCOHOL drinking, BASAL cell carcinoma, DISEASE risk factors, SQUAMOUS cell carcinoma
Abstract: Experimental evidence suggests that alcohol induces cutaneous carcinogenesis, yet epidemiological studies on the link between alcohol intake and skin cancer have been inconsistent. The European Prospective Investigation into Cancer and Nutrition (EPIC) is a prospective cohort initiated in 1992 in 10 European countries. Alcohol intake at baseline and average lifetime alcohol intake were assessed using validated country‐specific dietary and lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated in Cox models. A total of 14 037 skin cancer cases (melanoma: n = 2457; basal‐cell carcinoma (BCC): n = 8711; squamous‐cell carcinoma (SCC): n = 1928; unknown: n = 941) were identified among 450 112 participants (average follow‐up: 15 years). Baseline alcohol intake was positively associated with SCC (>15 vs 0.1‐4.9 g/day: HR = 1.44, 95% CI = 1.17‐1.77; Ptrend =.001), BCC (HR = 1.12, 95% CI = 1.01‐1.23; Ptrend =.04), and melanoma risks in men (HR = 1.17, 95% CI = 0.95‐1.44; Ptrend =.17), while associations were more modest in women (SCC: HR = 1.09, 95% CI = 0.90‐1.30; Ptrend =.13; BCC: HR = 1.08, 95% CI = 1.00‐1.17, Ptrend =.03; melanoma: HR = 0.93, 95% CI = 0.80‐1.08, Ptrend =.13). Associations were similar for lifetime alcohol intake, with an attenuated linear trend. Lifetime liquor/spirit intake was positively associated with melanoma (fourth vs first quartile: HR = 1.47, 95% CI = 1.08‐1.99; Ptrend =.0009) and BCC risks in men (HR = 1.17, 95% CI = 1.04‐1.31; Ptrend =.14). Baseline and lifetime intakes of wine were associated with BCC risk (HR = 1.25 in men; HR = 1.11‐1.12; in women). No statistically significant associations were found between beverage types and SCC risk. Intake of beer was not associated with skin cancer risk. Our study suggests positive relationships between alcohol intake and skin cancer risk, which may have important implications for the primary prevention of skin cancer. What's new? Drinking alcohol can make the skin more sensitive to sunlight and vulnerable to skin cancer. Here, the authors conducted a large prospective cohort study to evaluate whether alcohol consumption correlates with skin cancer risk. Among the 450 112 participants, there were 2457 cases of melanoma, 8711 of basal cell carcinoma, and 1928 of squamous cell carcinoma. There was a positive association between alcohol and all three cancer types, stronger in men than in women. The association varied somewhat by beverage type. [ABSTRACT FROM AUTHOR]
Published: 2023
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262. Dietary intake of B vitamins and methionine and prostate cancer incidence and mortality

Author: Bassett, Julie K., Severi, Gianluca, Hodge, Allison M., Baglietto, Laura, Hopper, John L., English, Dallas R., and Giles, Graham G.
Published: 2012

263. Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Author: Robbins, Hilary A, primary, Alcala, Karine, additional, Khodayari Moez, Elham, additional, Guida, Florence, additional, Thomas, Sera, additional, Zahed, Hana, additional, Warkentin, Matthew, additional, Smith-Byrne, Karl, additional, Brhane, Yonathan, additional, Muller, David, additional, Albanes, Demetrius, additional, Aldrich, Melinda C, additional, Arslan, Alan A, additional, Bassett, Julie, additional, Berg, Christine D, additional, Cai, Qiuyin, additional, Chen, Chu, additional, Davies, Michael PA, additional, Diergaarde, Brenda, additional, Field, John K, additional, Freedman, Neal D, additional, Huang, Wen-Yi, additional, Johansson, Mikael, additional, Jones, Michael, additional, Koh, Woon-Puay, additional, Lam, Stephen, additional, Lan, Qing, additional, Langhammer, Arnulf, additional, Liao, Linda M, additional, Liu, Geoffrey, additional, Malekzadeh, Reza, additional, Milne, Roger L, additional, Montuenga, Luis M, additional, Rohan, Thomas, additional, Sesso, Howard D, additional, Severi, Gianluca, additional, Sheikh, Mahdi, additional, Sinha, Rashmi, additional, Shu, Xiao-Ou, additional, Stevens, Victoria L, additional, Tammemägi, Martin C, additional, Tinker, Lesley F, additional, Visvanathan, Kala, additional, Wang, Ying, additional, Wang, Renwei, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wilson, David, additional, Yuan, Jian-Min, additional, Zhang, Xuehong, additional, Zheng, Wei, additional, Amos, Christopher I, additional, Brennan, Paul, additional, Johansson, Mattias, additional, and Hung, Rayjean J, additional
Published: 2022
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264. Prediagnosis Leisure-Time Physical Activity and Lung Cancer Survival: A Pooled Analysis of 11 Cohorts

Author: Yang, Jae Jeong, primary, Yu, Danxia, additional, White, Emily, additional, Lee, Dong Hoon, additional, Blot, William, additional, Robien, Kim, additional, Sinha, Rashmi, additional, Park, Yikyung, additional, Takata, Yumie, additional, Gao, Yu-Tang, additional, Smith-Byrne, Karl, additional, Monninkhof, Evelyn M, additional, Kaaks, Rudolf, additional, Langhammer, Arnulf, additional, Borch, Kristin Benjaminsen, additional, Al-Shaar, Laila, additional, Lan, Qing, additional, Sørgjerd, Elin Pettersen, additional, Zhang, Xuehong, additional, Zhu, Clair, additional, Chirlaque, María Dolores, additional, Severi, Gianluca, additional, Overvad, Kim, additional, Sacerdote, Carlotta, additional, Aune, Dagfinn, additional, Johansson, Mattias, additional, Smith-Warner, Stephanie A, additional, Zheng, Wei, additional, and Shu, Xiao-Ou, additional
Published: 2022
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265. Colorectal cancer risk following appendectomy: a pooled analysis of three large prospective cohort studies

Author: Rothwell, Joseph A., primary, Mori, Nagisa, additional, Artaud, Fanny, additional, Fournier, Agnès, additional, Conte, Marco, additional, Boutron‐Ruault, Marie‐Christine, additional, Chan, Simon S. M., additional, Gunter, Marc J., additional, Murphy, Neil, additional, and Severi, Gianluca, additional
Published: 2022
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266. Comparison of Fecal Sample Collection Methods for Microbial Analysis Embedded within Colorectal Cancer Screening Programs

Author: Zouiouich, Semi, primary, Mariadassou, Mahendra, additional, Rué, Olivier, additional, Vogtmann, Emily, additional, Huybrechts, Inge, additional, Severi, Gianluca, additional, Boutron-Ruault, Marie-Christine, additional, Senore, Carlo, additional, Naccarati, Alessio, additional, Mengozzi, Giulio, additional, Kozlakidis, Zisis, additional, Jenab, Mazda, additional, Sinha, Rashmi, additional, Gunter, Marc J., additional, and Leclerc, Marion, additional
Published: 2022
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267. Excess Body Fatness during Early to Mid-Adulthood and Survival from Colorectal and Breast Cancer: A Pooled Analysis of Five International Cohort Studies

Author: Charvat, Hadrien, primary, Freisling, Heinz, additional, Noh, Hwayoung, additional, Gaudet, Mia M., additional, Gunter, Marc J., additional, Cross, Amanda J., additional, Tsilidis, Konstantinos K., additional, Tjønneland, Anne, additional, Katzke, Verena, additional, Bergmann, Manuela, additional, Agnoli, Claudia, additional, Rylander, Charlotta, additional, Skeie, Guri, additional, Jakszyn, Paula, additional, Rosendahl, Ann H., additional, Sund, Malin, additional, Severi, Gianluca, additional, Tsugane, Shoichiro, additional, Sawada, Norie, additional, Brenner, Hermann, additional, Adami, Hans-Olov, additional, Weiderpass, Elisabete, additional, Soerjomataram, Isabelle, additional, and Arnold, Melina, additional
Published: 2022
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268. Prediagnostic alterations in circulating bile acid profiles in the development of hepatocellular carcinoma

Author: Stepien, Magdalena, primary, Lopez‐Nogueroles, Marina, additional, Lahoz, Agustin, additional, Kühn, Tilman, additional, Perlemuter, Gabriel, additional, Voican, Cosmin, additional, Ciocan, Dragos, additional, Boutron‐Ruault, Marie‐Christine, additional, Jansen, Eugene, additional, Viallon, Vivian, additional, Leitzmann, Michael, additional, Tjønneland, Anne, additional, Severi, Gianluca, additional, Mancini, Francesca Romana, additional, Dong, Catherine, additional, Kaaks, Rudolf, additional, Fortner, Renee Turzanski, additional, Bergmann, Manuela M., additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Karakatsani, Anna, additional, Peppa, Eleni, additional, Palli, Domenico, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno‐de‐Mesquita, H. Bas, additional, Skeie, Guri, additional, Merino, Susana, additional, Ros, Raul Zamora, additional, Sánchez, Maria Jose, additional, Amiano, Pilar, additional, Huerta, Jose Mª, additional, Barricarte, Aurelio, additional, Sjöberg, Klas, additional, Ohlsson, Bodil, additional, Nyström, Hanna, additional, Werner, Marten, additional, Perez‐Cornago, Aurora, additional, Schmidt, Julie A., additional, Freisling, Heinz, additional, Scalbert, Augustin, additional, Weiderpass, Elisabete, additional, Christakoudi, Sofia, additional, Gunter, Marc J., additional, and Jenab, Mazda, additional
Published: 2022
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269. Epigenome-wide methylation in DNA from peripheral blood as a marker of risk for breast cancer

Author: Severi, Gianluca, Southey, Melissa C., English, Dallas R., Jung, Chol-hee, Lonie, Andrew, McLean, Catriona, Tsimiklis, Helen, Hopper, John L., Giles, Graham G., and Baglietto, Laura
Published: 2014
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270. Additive Interactions Between Susceptibility Single-Nucleotide Polymorphisms Identified in Genome-Wide Association Studies and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

Author: Joshi, Amit D., Lindström, Sara, Hüsing, Anika, Barrdahl, Myrto, VanderWeele, Tyler J., Campa, Daniele, Canzian, Federico, Gaudet, Mia M., Figueroa, Jonine D., Baglietto, Laura, Berg, Christine D., Buring, Julie E., Chanock, Stephen J., Chirlaque, María-Dolores, Diver, W. Ryan, Dossus, Laure, Giles, Graham G., Haiman, Christopher A., Hankinson, Susan E., Henderson, Brian E., Hoover, Robert N., Hunter, David J., Isaacs, Claudine, Kaaks, Rudolf, Kolonel, Laurence N., Krogh, Vittorio, Le Marchand, Loic, Lee, I-Min, Lund, Eiliv, McCarty, Catherine A., Overvad, Kim, Peeters, Petra H., Riboli, Elio, Schumacher, Fredrick, Severi, Gianluca, Stram, Daniel O., Sund, Malin, Thun, Michael J., Travis, Ruth C., Trichopoulos, Dimitrios, Willett, Walter C., Zhang, Shumin, Ziegler, Regina G., Kraft, Peter, Joshi, Amit D., Lindström, Sara, Hunter, David J., Kraft, Peter, Hüsing, Anika, Barrdahl, Myrto, Kaaks, Rudolf, Kraft, Peter, VanderWeele, Tyler J., Trichopoulos, Dimitrios, Campa, Daniele, VanderWeele, Tyler J., Campa, Daniele, Canzian, Federico, Gaudet, Mia M., Figueroa, Jonine D., Chanock, Stephen J., Hoover, Robert N., Ziegler, Regina G., Baglietto, Laura, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, Giles, Graham G., Severi, Gianluca, Berg, Christine D., Buring, Julie E., Lee, I-Min, Zhang, Shumin, Chirlaque, María-Dolores, Chirlaque, María-Dolores, Diver, W. Ryan, Thun, Michael J., Dossus, Laure, Dossus, Laure, Giles, Graham G., Haiman, Christopher A., Schumacher, Fredrick, Stram, Daniel O., Henderson, Brian E., Hankinson, Susan E., Isaacs, Claudine, Kolonel, Laurence N., Krogh, Vittorio, Marchand, Loic Le, Lund, Eiliv, McCarty, Catherine A., Overvad, Kim, Peeters, Petra H., Peeters, Petra H., Riboli, Elio, Sund, Malin, Travis, Ruth C., Trichopoulos, Dimitrios, Trichopoulos, Dimitrios, and Willett, Walter C.
Published: 2014
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271. Nutritional risk factors for SARS-CoV-2 infection: a prospective study within the NutriNet-Santé cohort

Author: Deschasaux-Tanguy, Mélanie, Srour, Bernard, Bourhis, Laurent, Arnault, Nathalie, Druesne-Pecollo, Nathalie, Esseddik, Younes, de Edelenyi, Fabien Szabo, Allègre, Julien, Allès, Benjamin, Andreeva, Valentina A., Baudry, Julia, Fezeu, Leopold K., Galan, Pilar, Julia, Chantal, Kesse-Guyot, Emmanuelle, Péneau, Sandrine, Hercberg, Serge, Bajos, Nathalie, Severi, Gianluca, Zins, Marie, de Lamballerie, Xavier, Carrat, Fabrice, Touvier, Mathilde, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), Institut de Recherche Interdisciplinaire sur les enjeux Sociaux - sciences sociales, politique, santé (IRIS), École des hautes études en sciences sociales (EHESS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Sorbonne Paris Nord, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), Università degli Studi di Firenze = University of Florence (UniFI), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), The SAPRIS/SAPRIS-SERO projects received funding from ANR (Agence Nationale de la Recherche, #ANR-20-COVI-000, #ANR-10-COHO-06), Fondation pour la Recherche Médicale (#20RR052-00), and Inserm (InstitutNational de la Santé et de la Recherche Médicale, #C20-26). The NutriNetSanté cohort study was supported by the following public institutions: Ministère de la Santé, Santé Publique France, Institut National de la Santé et de laRecherche Médicale (INSERM), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Conservatoire National des Arts et Métiers (CNAM) and Université Sorbonne Paris Nord. Study investigators are independent from the funders. Funders had no role in the study design, the collection, analysis, and interpretation of data, the writing of themanuscript, or the decision to submit the article for publication., SAPRIS-SERO study group: Fabrice Carrat, Pierre-Yves Ancel, Nathalie Bajos, Marie-Aline Charles, Gianluca Severi, Mathilde Touvier, Marie Zins, Sofiane Kab, Adeline Renuy, Stephane Le-Got, Celine Ribet, Emmanuel Wiernik, Marcel Goldberg, Marie Zins, Fanny Artaud, Pascale Gerbouin-Rérolle, Mélody Enguix, Camille Laplanche, Roselyn Gomes-Rima, Lyan Hoang, Emmanuelle Correia, Alpha Amadou Barry, Nadège Senina, Gianluca Severi, Fabien Szabo de Edelenyi, Julien Allègre, Nathalie Druesne-Pecollo, Younes Esseddik, Serge Hercberg, Mathilde Touvier, Marie-Aline Charles, Pierre-Yves Ancel, Valérie Benhammou, Anass Ritmi, Laetitia Marchand, Cecile Zaros, Elodie Lordmi, Adriana Candea, Sophie de Visme, Thierry Simeon, Xavier Thierry, Bertrand Geay, Marie-Noelle Dufourg, Karen Milcent, Clovis Lusivika-Nzinga, Gregory Pannetier, Nathanael Lapidus, Isabelle Goderel, Céline Dorival, Jérôme Nicol, Fabrice Carrat, Cindy Lai, Hélène Esperou, Sandrine Couffin-Cadiergues, Jean-Marie Gagliolo, Hélène Blanché, Jean-Marc Sébaoun, Jean-Christophe Beaudoin, Laetitia Gressin, Valérie Morel, Ouissam Ouili, Jean-François Deleuze, Stéphane Priet, Paola Mariela Saba Villarroel, Toscane Fourié, Souand Mohamed Ali, Abdenour Amroun, Morgan Seston, Nazli Ayhan, Boris Pastorino, Xavier de Lamballerie, European Project: 637408,NHMRC::Early Career Fellowships(2010), Malbec, Odile, INSERM - - NHMRC::Early Career Fellowships2010-01-01 - 2010-12-31 - 637408 - VALID, Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Sorbonne Paris Nord-École des hautes études en sciences sociales (EHESS), Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université de Paris (UP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), and ANR-20-COVI-0009,SAPRIS,Santé, perception, pratiques, relations et inégalités sociales en population générale pendant la crise COVID-19(2020)
Subjects: Adult, Male, SARS-CoV-2, [SDV]Life Sciences [q-bio], COVID-19, Seroprevalence, Vitamins, Middle Aged, Diet, Cohort Studies, [SDV] Life Sciences [q-bio], Risk Factors, Seroepidemiologic Studies, Humans, Female, Prospective Studies, Cohort study, Pandemics, Research Article
Abstract: Background Nutritional factors are essential for the functioning of the immune system and could therefore play a role in COVID-19 but evidence is needed. Our objective was to study the associations between diet and the risk of SARS-CoV-2 infection in a large population-based sample. Methods Our analyses were conducted in the French prospective NutriNet-Santé cohort study (2009–2020). Seroprevalence of anti-SARS-CoV-2 antibodies was assessed by ELISA on dried blood spots. Dietary intakes were derived from repeated 24 h dietary records (at least 6) in the two years preceding the start of the COVID-19 pandemic in France (February 2020). Multi-adjusted logistic regression models were computed. Results A total of 7766 adults (70.3% women, mean age: 60.3 years) were included, among which 311 were positive for anti-SARS-CoV-2 antibodies. Dietary intakes of vitamin C (OR for 1 SD=0.86 (0.75–0.98), P=0.02), vitamin B9 (OR=0.84 (0.72–0.98), P=0.02), vitamin K (OR=0.86 (0.74–0.99), P=0.04), fibers (OR=0.84 (0.72–0.98), P=0.02), and fruit and vegetables (OR=0.85 (0.74–0.97), P=0.02) were associated to a decreased probability of SARS-CoV-2 infection while dietary intakes of calcium (OR=1.16 (1.01–1.35), P=0.04) and dairy products (OR=1.19 (1.06–1.33), P=0.002) associated to increased odds. No association was detected with other food groups or nutrients or with the overall diet quality. Conclusions Higher dietary intakes of fruit and vegetables and, consistently, of vitamin C, folate, vitamin K and fibers were associated with a lower susceptibility to SARS-CoV-2 infection. Beyond its established role in the prevention of non-communicable diseases, diet could therefore also contribute to prevent some infectious diseases such as COVID-19. Supplementary Information The online version contains supplementary material available at 10.1186/s12916-021-02168-1.
Published: 2021

272. Association between anthropometry and lifestyle factors and risk of B-cell lymphoma

Author: Saberi Hosnijeh, Fatemeh, Casabonne, Delphine, Nieters, Alexandra, Solans, Marta, Naudin, Sabine, Ferrari, Pietro, Mckay, James D., Benavente, Yolanda, Weiderpass, Elisabete, Freisling, Heinz, Severi, Gianluca, Boutron Ruault, Marie-Christine, Besson, Caroline, Agnoli, Claudia, Masala, Giovanna, Sacerdote, Carlotta, Tumino, Rosario, Huerta, Jose Maria, Amiano, Pilar, Rodriguez-Barranco, Miguel, Bonet, Catalina, Barricarte, Aurelio, Christakoudi, Sofia, Knuppel, Anika, Bueno-de-Mesquita, Bas, Schulze, Matthias B. (Prof. Dr.), Kaaks, Rudolf, Canzian, Federico, Spath, Florentin, Jerkeman, Mats, Rylander, Charlotta, Tjonneland, Anne, Olsen, Anja, Borch, Kristin Benjaminsen, and Vermeulen, Roel
Subjects: Institut für Ernährungswissenschaft, ddc:500
Abstract: To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Cancer and nutrition study, 2402 incident BCL cases were diagnosed from 475 426 participants that were followed-up on average 14 years. Standard and penalized Cox regression models as well as principal component analysis (PCA) were used to evaluate 84 exposures in relation to BCL risk. Standard and penalized Cox regression models showed a positive association between anthropometric measures and BCL and multiple myeloma/plasma cell neoplasm (MM). The penalized Cox models additionally showed the association between several exposures from categories of physical activity, smoking status, medical history, socioeconomic position, diet and BCL and/or the subtypes. PCAs confirmed the individual associations but also showed additional observations. The PC5 including anthropometry, was positively associated with BCL, diffuse large B-cell lymphoma (DLBCL) and MM. There was a significant positive association between consumption of sugar and confectionary (PC11) and follicular lymphoma risk, and an inverse association between fish and shellfish and Vitamin D (PC15) and DLBCL risk. The PC1 including features of the Mediterranean diet and diet with lower inflammatory score showed an inverse association with BCL risk, while the PC7, including dairy, was positively associated with BCL and DLBCL risk. Physical activity (PC10) was positively associated with DLBCL risk among women. This study provided informative insights on the etiology of BCL.
Published: 2021

273. A Prospective Study of the Immune System Activation Biomarker Neopterin and Colorectal Cancer Risk

Author: Aleksandrova, Krasimira, Chuang, Shu-Chun, Boeing, Heiner, Zuo, Hui, Tell, Grethe S., Pischon, Tobias, Jenab, Mazda, Bueno-de-Mesquita, Bas, Vollset, Stein Emil, Midttun, Øivind, Ueland, Per Magne, Fedirko, Veronika, Johansson, Mattias, Weiderpass, Elisabete, Severi, Gianluca, Racine, Antoine, Boutron-Ruault, Marie-Christine, Kaaks, Rudolf, Kühn, Tilman, Tjønneland, Anne, Overvad, Kim, Quirós, J. Ramón, Jakszyn, Paula, Sánchez, María-José, Dorronsoro, Miren, Chirlaque, Maria-Dolores, Ardanaz, Eva, Khaw, Kay-Tee, Wareham, Nicholas J., Travis, Ruth C., Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Palli, Domenico, Sieri, Sabina, Tumino, Rosario, Panico, Salvatore, May, Anne M., Palmqvist, Richard, Ljuslinder, Ingrid, Kong, So Yeon J., Freisling, Heinz, Gunter, Marc J., Lu, Yunxia, Cross, Amanda J., Riboli, Elio, and Vineis, Paolo
Published: 2015
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274. Circulating Biomarkers of One-Carbon Metabolism in Relation to Renal Cell Carcinoma Incidence and Survival

Author: Johansson, Mattias, Fanidi, Anouar, Muller, David C., Bassett, Julie K., Midttun, Øivind, Vollset, Stein Emil, Travis, Ruth C., Palli, Domenico, Mattiello, Amalia, Sieri, Sabina, Trichopoulou, Antonia, Lagiou, Pagona, Trichopoulos, Dimitrios, Ljungberg, Börje, Hallmans, Göran, Weiderpass, Elisabete, Skeie, Guri, González, Carlos A., Dorronsoro, Miren, Peeters, Petra H., Bueno-de-Mesquita, H. B(as)., Ros, Martine M., Boutron Ruault, Marie-Christine, Fagherazzi, Guy, Clavel, Françoise, Sánchez, María-José, Gurrea, Aurelio Barricarte, Navarro, Carmen, Quiros, J. Ramon, Overvad, Kim, Tjønneland, Anne, Aleksandrova, Krassimira, Vineis, Paolo, Gunter, Marc J., Kaaks, Rudolf, Giles, Graham, Relton, Caroline, Riboli, Elio, Boeing, Heiner, Ueland, Per Magne, Severi, Gianluca, and Brennan, Paul
Published: 2014
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275. RETRACTED: Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author: Sofianopoulou, Eleni, Kaptoge, Stephen K, Afzal, Shoaib, Jiang, Tao, Gill, Dipender, Gundersen, Thomas E, Bolton, Thomas R, Allara, Elias, Arnold, Matthew G, Mason, Amy M, Chung, Ryan, Pennells, Lisa A M, Shi, Fanchao, Sun, Luanluan, Willeit, Peter, Forouhi, Nita G, Langenberg, Claudia, Sharp, Stephen J, Panico, Salvatore, Engström, Gunnar, Melander, Olle, Tong, Tammy Y N, Perez-Cornago, Aurora, Norberg, Margareta, Johansson, Ingegerd, Katzke, Verena, Srour, Bernard, José Sánchez, María, Redondo-Sánchez, Daniel, Olsen, Anja, Dahm, Christina C, Overvad, Kim, Brustad, Magritt, Skeie, Guri, Moreno-Iribas, Conchi, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Tsilidis, Konstantinos K, Heath, Alicia K, Agnoli, Claudia, Krogh, Vittorio, de Boer, Ian H, Kobylecki, Camilla Jannie, Çolak, Yunus, Zittermann, Armin, Sundström, Johan, Welsh, Paul, Weiderpass, Elisabete, Aglago, Elom K, Ferrari, Pietro, Clarke, Robert, Boutron, Marie-Christine, Severi, Gianluca, MacDonald, Conor, Providencia, Rui, Masala, Giovanna, Zamora Ros, Raul, Boer, Jolanda, Verschuren, WM Monique, Cawthon, Peggy, Schierbeck, Louise L, Cooper, Cyrus, Schulze, Matthias B, Bergmann, Manuela M, Hannemann, Anke, Kiechl, Stefan, Brenner, Hermann, van Schoor, Natasja M, Albertorio, Juan R, Sacerdote, Carlotta, Linneberg, Allan, Kårhus, Line L, Huerta, José María, Imaz, Liher, Joergensen, Christel, Ben-Shlomo, Yoav, Lundqvist, Annamari, Gallacher, John, Sattar, Naveed, Wood, Angela M, Wareham, Nicholas J, Nordestgaard, Børge G, Di Angelantonio, Emanuele, Danesh, John, Butterworth, Adam S, and Burgess, Stephen
Published: 2021
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276. Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality among Individuals with Colorectal Cancer

Author: Mao, Ziling, primary, Aglago, Elom K., additional, Zhao, Zhiwei, additional, Schalkwijk, Casper, additional, Jiao, Li, additional, Freisling, Heinz, additional, Weiderpass, Elisabete, additional, Hughes, David J., additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Severi, Gianluca, additional, Rothwell, Joseph, additional, Boutron-Ruault, Marie-Christine, additional, Katzke, Verena, additional, Kaaks, Rudolf, additional, Schulze, Matthias B., additional, Birukov, Anna, additional, Krogh, Vittorio, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Bueno-de-Mesquita, H. Bas, additional, Vermeulen, Roel C. H., additional, Gram, Inger T., additional, Skeie, Guri, additional, Sandanger, Torkjel M., additional, Quirós, J. Ramón, additional, Crous-Bou, Marta, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Barricarte Gurrea, Aurelio, additional, Manjer, Jonas, additional, Johansson, Ingegerd, additional, Perez-Cornago, Aurora, additional, Jenab, Mazda, additional, and Fedirko, Veronika, additional
Published: 2021
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277. Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses

Author: Sofianopoulou, Eleni, primary, Kaptoge, Stephen K, additional, Afzal, Shoaib, additional, Jiang, Tao, additional, Gill, Dipender, additional, Gundersen, Thomas E, additional, Bolton, Thomas R, additional, Allara, Elias, additional, Arnold, Matthew G, additional, Mason, Amy M, additional, Chung, Ryan, additional, Pennells, Lisa A M, additional, Shi, Fanchao, additional, Sun, Luanluan, additional, Willeit, Peter, additional, Forouhi, Nita G, additional, Langenberg, Claudia, additional, Sharp, Stephen J, additional, Panico, Salvatore, additional, Engström, Gunnar, additional, Melander, Olle, additional, Tong, Tammy Y N, additional, Perez-Cornago, Aurora, additional, Norberg, Margareta, additional, Johansson, Ingegerd, additional, Katzke, Verena, additional, Srour, Bernard, additional, José Sánchez, María, additional, Redondo-Sánchez, Daniel, additional, Olsen, Anja, additional, Dahm, Christina C, additional, Overvad, Kim, additional, Brustad, Magritt, additional, Skeie, Guri, additional, Moreno-Iribas, Conchi, additional, Onland-Moret, N Charlotte, additional, van der Schouw, Yvonne T, additional, Tsilidis, Konstantinos K, additional, Heath, Alicia K, additional, Agnoli, Claudia, additional, Krogh, Vittorio, additional, de Boer, Ian H, additional, Kobylecki, Camilla Jannie, additional, Çolak, Yunus, additional, Zittermann, Armin, additional, Sundström, Johan, additional, Welsh, Paul, additional, Weiderpass, Elisabete, additional, Aglago, Elom K, additional, Ferrari, Pietro, additional, Clarke, Robert, additional, Boutron, Marie-Christine, additional, Severi, Gianluca, additional, MacDonald, Conor, additional, Providencia, Rui, additional, Masala, Giovanna, additional, Zamora Ros, Raul, additional, Boer, Jolanda, additional, Verschuren, WM Monique, additional, Cawthon, Peggy, additional, Schierbeck, Louise L, additional, Cooper, Cyrus, additional, Schulze, Matthias B, additional, Bergmann, Manuela M, additional, Hannemann, Anke, additional, Kiechl, Stefan, additional, Brenner, Hermann, additional, van Schoor, Natasja M, additional, Albertorio, Juan R, additional, Sacerdote, Carlotta, additional, Linneberg, Allan, additional, Kårhus, Line L, additional, Huerta, José María, additional, Imaz, Liher, additional, Joergensen, Christel, additional, Ben-Shlomo, Yoav, additional, Lundqvist, Annamari, additional, Gallacher, John, additional, Sattar, Naveed, additional, Wood, Angela M, additional, Wareham, Nicholas J, additional, Nordestgaard, Børge G, additional, Di Angelantonio, Emanuele, additional, Danesh, John, additional, Butterworth, Adam S, additional, and Burgess, Stephen, additional
Published: 2021
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278. Are Circulating Immune Cells a Determinant of Pancreatic Cancer Risk? A Prospective Study Using Epigenetic Cell Count Measures

Author: Katzke, Verena A., primary, Le Cornet, Charlotte, additional, Mahfouz, Rayaan, additional, Brauer, Bianca, additional, Johnson, Theron, additional, Canzian, Federico, additional, Rebours, Vinciane, additional, Boutron-Ruault, Marie-Christine, additional, Severi, Gianluca, additional, Schulze, Matthias B., additional, Olsen, Anja, additional, Tjønneland, Anne, additional, Overvad, Kim, additional, Crous-Bou, Marta, additional, Molina-Montes, Esther, additional, Amiano, Pilar, additional, Huerta, José María, additional, Ardanaz, Eva, additional, Perez-Cornago, Aurora, additional, Masala, Giovanna, additional, Pala, Valeria, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, Vermeulen, Roel, additional, Sund, Malin, additional, Franklin, Oskar, additional, Christakoudi, Sofia, additional, Dossus, Laure, additional, Weiderpass, Elisabete, additional, Olek, Sven, additional, and Kaaks, Rudolf, additional
Published: 2021
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279. Lifestyle correlates of eight breast cancer-related metabolites: a cross-sectional study within the EPIC cohort

Author: His, Mathilde, primary, Viallon, Vivian, additional, Dossus, Laure, additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Gunter, Marc J., additional, Overvad, Kim, additional, Kyrø, Cecilie, additional, Tjønneland, Anne, additional, Lécuyer, Lucie, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Johnson, Theron, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Sieri, Sabina, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Macciotta, Alessandra, additional, Boer, Jolanda M. A., additional, Monninkhof, Evelyn M., additional, Olsen, Karina Standahl, additional, Nøst, Therese H., additional, Sandanger, Torkjel M., additional, Agudo, Antonio, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Colorado-Yohar, Sandra M., additional, Ardanaz, Eva, additional, Vidman, Linda, additional, Winkvist, Anna, additional, Heath, Alicia K., additional, Weiderpass, Elisabete, additional, Huybrechts, Inge, additional, and Rinaldi, Sabina, additional
Published: 2021
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280. Exposure to airborne cadmium and breast cancer stage, grade and histology at diagnosis: findings from the E3N cohort study

Author: Amadou, Amina, primary, Praud, Delphine, additional, Coudon, Thomas, additional, Danjou, Aurélie M. N., additional, Faure, Elodie, additional, Deygas, Floriane, additional, Grassot, Lény, additional, Leffondré, Karen, additional, Severi, Gianluca, additional, Salizzoni, Pietro, additional, Mancini, Francesca Romana, additional, and Fervers, Béatrice, additional
Published: 2021
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281. Urinary Concentrations of (+)-Catechin and (-)-Epicatechin as Biomarkers of Dietary Intake of Flavan-3-ols in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author: Almanza-Aguilera, Enrique, primary, Ceballos-Sánchez, Daniela, additional, Achaintre, David, additional, Rothwell, Joseph A, additional, Laouali, Nasser, additional, Severi, Gianluca, additional, Katzke, Verena, additional, Johnson, Theron, additional, Schulze, Matthias B, additional, Palli, Domenico, additional, Gargano, Giuliana, additional, de Magistris, Maria Santucci, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Scalbert, Augustin, additional, and Zamora-Ros, Raul, additional
Published: 2021
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282. Co-benefits from sustainable dietary shifts for population and environmental health: an assessment from a large European cohort study

Author: Laine, Jessica E, primary, Huybrechts, Inge, additional, Gunter, Marc J, additional, Ferrari, Pietro, additional, Weiderpass, Elisabete, additional, Tsilidis, Kostas, additional, Aune, Dagfinn, additional, Schulze, Matthias B, additional, Bergmann, Manuela, additional, Temme, Elisabeth H M, additional, Boer, Jolanda M A, additional, Agnoli, Claudia, additional, Ericson, Ulrika, additional, Stubbendorff, Anna, additional, Ibsen, Daniel B, additional, Dahm, Christina Catherine, additional, Deschasaux, Mélanie, additional, Touvier, Mathilde, additional, Kesse-Guyot, Emmanuelle, additional, Sánchez Pérez, Maria-Jose, additional, Rodríguez Barranco, Miguel, additional, Tong, Tammy Y N, additional, Papier, Keren, additional, Knuppel, Anika, additional, Boutron-Ruault, Marie-Christine, additional, Mancini, Francesca, additional, Severi, Gianluca, additional, Srour, Bernard, additional, Kühn, Tilman, additional, Masala, Giovanna, additional, Agudo, Antonio, additional, Skeie, Guri, additional, Rylander, Charlotta, additional, Sandanger, Torkjel M, additional, Riboli, Elio, additional, and Vineis, Paolo, additional
Published: 2021
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283. Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?

Author: Yu, Chenglong, primary, Hodge, Allison M, additional, Wong, Ee Ming, additional, Joo, Jihoon E, additional, Makalic, Enes, additional, Schmidt, Daniel F, additional, Buchanan, Daniel D, additional, Severi, Gianluca, additional, Hopper, John L, additional, English, Dallas R, additional, Giles, Graham G, additional, Milne, Roger L, additional, Southey, Melissa C, additional, and Dugué, Pierre-Antoine, additional
Published: 2021
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284. Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations

Author: Baker, Jacqueline Roshelli, primary, Umesh, Sushma, additional, Jenab, Mazda, additional, Schomburg, Lutz, additional, Tjønneland, Anne, additional, Olsen, Anja, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Katzke, Verena, additional, Johnson, Theron, additional, Schulze, Matthias B., additional, Masala, Giovanna, additional, Agnoli, Claudia, additional, Simeon, Vittorio, additional, Tumino, Rosario, additional, Bueno-de-Mesquita, H. Bas, additional, Gram, Inger Torhild, additional, Skeie, Guri, additional, Bonet, Catalina, additional, Rodriguez-Barranco, Miguel, additional, Houerta, José María, additional, Gylling, Björn, additional, Van Guelpen, Bethany, additional, Perez-Cornago, Aurora, additional, Aglago, Elom, additional, Freisling, Heinz, additional, Weiderpass, Elisabete, additional, Cross, Amanda J., additional, Heath, Alicia K., additional, Hughes, David J., additional, and Fedirko, Veronika, additional
Published: 2021
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285. Inflammation-Related Marker Profiling of Dietary Patterns and All-cause Mortality in the Melbourne Collaborative Cohort Study

Author: Li, Sherly X, primary, Hodge, Allison M, additional, MacInnis, Robert J, additional, Bassett, Julie K, additional, Ueland, Per M, additional, Midttun, Øivind, additional, Ulvik, Arve, additional, Rinaldi, Sabina, additional, Meyer, Klaus, additional, Navionis, Anne-Sophie, additional, Shivappa, Nitin, additional, Hébert, James R, additional, Flicker, Leon, additional, Severi, Gianluca, additional, Jayasekara, Harindra, additional, English, Dallas R, additional, Vineis, Paolo, additional, Southey, Melissa C, additional, Milne, Roger L, additional, Giles, Graham G, additional, and Dugué, Pierre-Antoine, additional
Published: 2021
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286. Diabetes, hypertension, body mass index, smoking and COVID-19-related mortality: a systematic review and meta-analysis of observational studies

Author: Mahamat-Saleh, Yahya, primary, Fiolet, Thibault, additional, Rebeaud, Mathieu Edouard, additional, Mulot, Matthieu, additional, Guihur, Anthony, additional, El Fatouhi, Douae, additional, Laouali, Nasser, additional, Peiffer-Smadja, Nathan, additional, Aune, Dagfinn, additional, and Severi, Gianluca, additional
Published: 2021
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287. Exposure to long-term nitrogen dioxide air pollution and breast cancer risk: A nested case-control within the French E3N cohort study

Author: Amadou, Amina, Praud, Delphine, Coudon, Thomas, Deygas, Floriane, Grassot, Lény, Dubuis, Mathieu, Faure, Elodie, Couvidat, Florian, Caudeville, Julien, BESSAGNET, Bertrand, Salizzoni, Pietro, Leffondré, Karen, Gulliver, John, Severi, Gianluca, Romana Mancini, Francesca, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut National de l'Environnement Industriel et des Risques (INERIS), Centre Interprofessionnel Technique d'Etude des Pollutions Atmosphériques (CITEPA), École Centrale de Lyon (ECL), Université de Lyon, Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Leicester, and International Society for Environmental Epidemiology
Subjects: hormone receptor status, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, breast cancer, [SDV]Life Sciences [q-bio], [SDE]Environmental Sciences, residential history, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Nitrogen dioxide, menopausal status
Abstract: International audience; BACKGROUND AND AIM: Nitrogen dioxide (NO2) is one of an important air pollutant due to its adverse effects on human health, however whether it is consistently associated with the risk of breast cancer (BC) is limited. In this study, we investigated the association between long term exposure to NO2 and risk of BC. METHODS: A total of 5,222 BC cases identified over the follow up period and 5,222 matched controls of a nested case-control study within a French E3N cohort study were examined. Mean exposure estimates to NO2 were estimated by CHIMERE and land use regression (LUR) models and assigned to the geocoded residential postal codes of participants for each year from recruitment 1990 through 2011. Multivariable conditional logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Overall, in all women, for each 1 interquartile range (IQR) increase in NO2 levels (CHIMERE: 11.1 ug/m3, LUR: 17.8 ug/m3), the ORs of the model adjusted for confounders were 1.16(95% CI: 1.06-1.26) and 1.09(95% CI: 1.01-1.18) according to CHIMERE and LUR measures, respectively. The corresponding ORs in the fully model additionally adjusted for established BC risk factors = 1.13(95% CI: 1.03-1.24) for CHIMERE and 1.07(95% CI: 0.99-1.16) for LUR measures. Comparable results were found for postmenopausal women. Substantial heterogeneity in the ORs was observed by hormone receptor status, using NO2 measured by CHIMERE the ORs of the model 3 was 1.17 (95% CI: 1.04-1.31) for ER. With LUR NO2, the OR of ER+BC in the fully model = 1.08 (95% CI: 0.98-1.19). CONCLUSIONS: We provide an evidence of an increase BC risk in association with long term exposure to NO2 air pollution according to CHIMERE and LUR measures, with risks being higher for CHIMERE model. Subgroup analyses suggested stronger effects especially in postmenopausal women and for hormone dependent BC.
Published: 2021

288. Use of systemic glucocorticoids and risk of breast cancer in a prospective cohort of postmenopausal women

Author: Cairat, Manon, Al Rahmoun, Marie, Gunter, Marc, Heudel, Pierre-Etienne, Severi, Gianluca, Dossus, Laure, Fournier, Agnès, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Léon Bérard [Lyon], Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Università degli Studi di Firenze = University of Florence (UniFI), ANR-10-COHO-0006,E4N,Etude Epidémiologique des Enfants de femmes de l'Education Nationale(2010), Malbec, Odile, and Cohortes - Etude Epidémiologique des Enfants de femmes de l'Education Nationale - - E4N2010 - ANR-10-COHO-0006 - COHO - VALID
Subjects: Pharmacoepidemiology, [SDV]Life Sciences [q-bio], Cancer stage, Cohort, Breast Neoplasms, Middle Aged, Risk Assessment, Postmenopausal women, [SDV] Life Sciences [q-bio], Postmenopause, Breast cancer, Molecular status, Risk Factors, Oestrogen receptors, Humans, Medicine, Female, Prospective Studies, Glucocorticoids, Proportional Hazards Models, Research Article
Abstract: Background Glucocorticoids could theoretically decrease breast cancer risk through their anti-inflammatory effects or increase risk through immunosuppression. However, epidemiological evidence is limited regarding the associations between glucocorticoid use and breast cancer risk. Methods We investigated the association between systemic glucocorticoid use and breast cancer incidence in the E3N cohort, which includes 98,995 women with information on various characteristics collected from repeated questionnaires complemented with drug reimbursement data available from 2004. Women with at least two reimbursements of systemic glucocorticoids in any previous 3-month period since January 1, 2004, were defined as exposed. We considered exposure as a time-varying parameter, and we used multivariable Cox regression models to estimate hazard ratios (HRs) of breast cancer. We performed a competing risk analysis using a cause-specific hazard approach to study the heterogeneity by tumour subtype/stage/grade. Results Among 62,512 postmenopausal women (median age at inclusion of 63 years old), 2864 developed breast cancer during a median follow-up of 9 years (between years 2004 and 2014). Compared with non-exposure, glucocorticoid exposure was not associated with overall breast cancer risk [HR = 0.94 (0.85–1.05)]; however, it was associated with a higher risk of in situ breast cancer and a lower risk of invasive breast cancer [HRinsitu = 1.34 (1.01–1.78); HRinvasive = 0.86 (0.76–0.97); Phomogeneity = 0.01]. Regarding the risk of invasive breast cancer, glucocorticoid exposure was inversely associated with oestrogen receptor (ER)-positive breast cancer [HRER+ = 0.82 (0.72–0.94); HRER− = 1.21 (0.88–1.66); Phomogeneity = 0.03]; it was also inversely associated with the risk of stage 1 or stage 2 tumours but positively associated with the risk of stage 3/4 breast cancers [HRstage1 = 0.87 (0.75–1.01); HRstage2 = 0.67 (0.52–0.86); HRstage3/4 = 1.49 (1.02–2.20); Phomogeneity = 0.01]. Conclusion This study suggests that the association between systemic glucocorticoid use and breast cancer risk may differ by tumour subtype and stage. Supplementary Information The online version contains supplementary material available at 10.1186/s12916-021-02004-6.
Published: 2021

289. Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA

Author: Earp, Madalene A., Kelemen, Linda E., Magliocco, Anthony M., Swenerton, Kenneth D., Chenevix-Trench, Georgia, Lu, Yi, Hein, Alexander, Ekici, Arif B., Beckmann, Matthias W., Fasching, Peter A., Lambrechts, Diether, Despierre, Evelyn, Vergote, Ignace, Lambrechts, Sandrina, Doherty, Jennifer A., Rossing, Mary Anne, Chang-Claude, Jenny, Rudolph, Anja, Friel, Grace, Moysich, Kirsten B., Odunsi, Kunle, Sucheston-Campbell, Lara, Lurie, Galina, Goodman, Marc T., Carney, Michael E., Thompson, Pamela J., Runnebaum, Ingo B., Dürst, Matthias, Hillemanns, Peter, Dörk, Thilo, Antonenkova, Natalia, Bogdanova, Natalia, Leminen, Arto, Nevanlinna, Heli, Pelttari, Liisa M., Butzow, Ralf, Bunker, Clareann H., Modugno, Francesmary, Edwards, Robert P., Ness, Roberta B., du Bois, Andreas, Heitz, Florian, Schwaab, Ira, Harter, Philipp, Karlan, Beth Y., Walsh, Christine, Lester, Jenny, Jensen, Allan, Kjær, Susanne K., Høgdall, Claus K., Høgdall, Estrid, Lundvall, Lene, Sellers, Thomas A., Fridley, Brooke L., Goode, Ellen L., Cunningham, Julie M., Vierkant, Robert A., Giles, Graham G., Baglietto, Laura, Severi, Gianluca, Southey, Melissa C., Liang, Dong, Wu, Xifeng, Lu, Karen, Hildebrandt, Michelle A. T., Levine, Douglas A., Bisogna, Maria, Schildkraut, Joellen M., Iversen, Edwin S., Weber, Rachel Palmieri, Berchuck, Andrew, Cramer, Daniel W., Terry, Kathryn L., Poole, Elizabeth M., Tworoger, Shelley S., Bandera, Elisa V., Chandran, Urmila, Orlow, Irene, Olson, Sara H., Wik, Elisabeth, Salvesen, Helga B., Bjorge, Line, Halle, Mari K., van Altena, Anne M., Aben, Katja K. H., Kiemeney, Lambertus A., Massuger, Leon F. A. G., Pejovic, Tanja, Bean, Yukie T., Cybulski, Cezary, Gronwald, Jacek, Lubinski, Jan, Wentzensen, Nicolas, Brinton, Louise A., Lissowska, Jolanta, Garcia-Closas, Montserrat, Dicks, Ed, Dennis, Joe, Easton, Douglas F., Song, Honglin, Tyrer, Jonathan P., Pharoah, Paul D. P., Eccles, Diana, Campbell, Ian G., Whittemore, Alice S., McGuire, Valerie, Sieh, Weiva, Rothstein, Joseph H., Flanagan, James M., Paul, James, Brown, Robert, Phelan, Catherine M., Risch, Harvey A., McLaughlin, John R., Narod, Steven A., Ziogas, Argyrios, Anton-Culver, Hoda, Gentry-Maharaj, Aleksandra, Menon, Usha, Gayther, Simon A., Ramus, Susan J., Wu, Anna H., Pearce, Celeste L., Pike, Malcolm C., Dansonka-Mieszkowska, Agnieszka, Rzepecka, Iwona K., Szafron, Lukasz M., Kupryjanczyk, Jolanta, Cook, Linda S., Le, Nhu D., Brooks-Wilson, Angela, Australian Cancer Study, Australian Ovarian Cancer Study Group, and On behalf of the Ovarian Cancer Association Consortium
Published: 2014
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290. Association analysis of 9,560 prostate cancer cases from the International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease

Author: Teerlink, Craig C., Thibodeau, Stephen N., McDonnell, Shannon K., Schaid, Daniel J., Rinckleb, Antje, Maier, Christiane, Vogel, Walther, Cancel-Tassin, Geraldine, Egrot, Christophe, Cussenot, Olivier, Foulkes, William D., Giles, Graham G., Hopper, John L., Severi, Gianluca, Eeles, Ros, Easton, Douglas, Kote-Jarai, Zsofia, Guy, Michelle, Cooney, Kathleen A., Ray, Anna M., Zuhlke, Kimberly A., Lange, Ethan M., FitzGerald, Liesel M., Stanford, Janet L., Ostrander, Elaine A., Wiley, Kathleen E., Isaacs, Sarah D., Walsh, Patrick C., Isaacs, William B., Wahlfors, Tiina, Tammela, Teuvo, Schleutker, Johanna, Wiklund, Fredrik, Grönberg, Henrik, Emanuelsson, Monica, Carpten, John, Bailey-Wilson, Joan, Whittemore, Alice S., Oakley-Girvan, Ingrid, Hsieh, Chih-Lin, Catalona, William J., Zheng, S. Lilly, Jin, Guangfu, Lu, Lingyi, Xu, Jianfeng, Camp, Nicola J., Cannon-Albright, Lisa A., and International Consortium for Prostate Cancer Genetics
Published: 2014
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291. Alteration of amino acid and biogenic amine metabolism in hepatobiliary cancers: Findings from a prospective cohort study

Author: Stepien, Magdalena, Duarte-Salles, Talita, Fedirko, Veronika, Floegel, Anne, Barupal, Dinesh Kumar, Rinaldi, Sabina, Achaintre, David, Assi, Nada, Tjnneland, Anne, Overvad, Kim, Bastide, Nadia, Boutron-Ruault, Marie-Christine, Severi, Gianluca, Kühn, Tilman, Kaaks, Rudolf, Aleksandrova, Krasimira, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Lagiou, Pagona, Saieva, Calogero, Agnoli, Claudia, Panico, Salvatore, Tumino, Rosario, Naccarati, Alessio, Bueno-de-Mesquita, H. B(as)., Peeters, Petra H., Weiderpass, Elisabete, Quirós, Ramón J., Agudo, Antonio, Sánchez, María-José, Dorronsoro, Miren, Gavrila, Diana, Barricarte, Aurelio, Ohlsson, Bodil, Sjöberg, Klas, Werner, Mårten, Sund, Malin, Wareham, Nick, Khaw, Kay-Tee, Travis, Ruth C., Schmidt, Julie A., Gunter, Marc, Cross, Amanda, Vineis, Paolo, Romieu, Isabelle, Scalbert, Augustin, and Jenab, Mazda
Published: 2016
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292. Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition.

Author: Breeur, Marie, Ferrari, Pietro, Dossus, Laure, Jenab, Mazda, Johansson, Mattias, Rinaldi, Sabina, Travis, Ruth C., His, Mathilde, Key, Tim J., Schmidt, Julie A., Overvad, Kim, Tjønneland, Anne, Kyrø, Cecilie, Rothwell, Joseph A., Laouali, Nasser, Severi, Gianluca, Kaaks, Rudolf, Katzke, Verena, Schulze, Matthias B., and Eichelmann, Fabian
Subjects: BLOOD testing, BODY mass index, DISEASE risk factors, HIERARCHICAL clustering (Cluster analysis), HEPATOCELLULAR carcinoma
Abstract: Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types. [ABSTRACT FROM AUTHOR]
Published: 2022
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293. Physical activity and stroke among women – A non-linear relationship

Author: MacDonald, Conor James, Madika, Anne-Laure, Gomes, Roselyn, Severi, Gianluca, Sibon, Igor, Debette, Stephanie, and Boutron-Ruault, Marie-Christine
Published: 2021
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294. Carotenoids, retinol, tocopherols, and prostate cancer risk: pooled analysis of 15 studies1-3

Author: Key, Timothy J, Appleby, Paul N, Travis, Ruth C, Albanes, Demetrius, Alberg, Anthony J, Barricarte, Aurelio, Black, Amanda, Boeing, Heiner, Bueno-de-Mesquita, H Bas, Chan, June M, Chen, Chu, Cook, Michael B, Donovan, Jenny L, Galan, Pilar, Gilbert, Rebecca, Giles, Graham G, Giovannucci, Edward, Goodman, Gary E, Goodman, Phyllis J, Gunter, Marc J, Hamdy, Freddie C, Heliövaara, Markku, Helzlsouer, Kathy J, Henderson, Brian E, Hercberg, Serge, Hoffman-Bolton, Judy, Hoover, Robert N, Johansson, Mattias, Khaw, Kay-Tee, King, Irena B, Knekt, Paul, Kolonel, Laurence N, Le Marchand, Loic, Männistö, Satu, Martin, Richard M, Meyer, Haakon E, Mondul, Alison M, Moy, Kristin A, Neal, David E, Neuhouser, Marian L, Palli, Domenico, Platz, Elizabeth A, Pouchieu, Camille, Rissanen, Harri, Schenk, Jeannette M, Severi, Gianluca, Stampfer, Meir J, Tjønneland, Anne, Touvier, Mathilde, Trichopoulou, Antonia, Weinstein, Stephanie J, Ziegler, Regina G, Zhou, Cindy Ke, Allen, Naomi E, and Biomarkers, Nutritional
Published: 2015

295. Do not neglect SARS-CoV-2 hospitalization and fatality risks in the middle-aged adult population

Author: Lapidus, Nathanael, Paireau, Juliette, Levy-Bruhl, Daniel, de Lamballerie, Xavier, Severi, Gianluca, Touvier, Mathilde, Zins, Marie, Cauchemez, Simon, and Carrat, Fabrice
Published: 2021
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296. Monitoring the proportion of the population infected by SARS-CoV-2 using age-stratified hospitalisation and serological data: a modelling study

Author: Hozé, Nathanaël, Paireau, Juliette, Lapidus, Nathanaël, Tran Kiem, Cécile, Salje, Henrik, Severi, Gianluca, Touvier, Mathilde, Zins, Marie, De Lamballerie, Xavier, Lévy-Bruhl, Daniel, Carrat, Fabrice, Cauchemez, Simon, Modélisation mathématique des maladies infectieuses - Mathematical modelling of Infectious Diseases, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Santé publique France - French National Public Health Agency [Saint-Maurice, France], Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université - Département de santé publique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Collège doctoral [Sorbonne universités], Sorbonne Université (SU), University of Cambridge [UK] (CAM), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Università degli Studi di Firenze = University of Florence [Firenze] (UNIFI), Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153), Université Sorbonne Paris Nord-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Sorbonne Université - Faculté de Médecine (SU FM), Unité des Virus Emergents (UVE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Support for this study was provided by Agence Nationale de la Recherche (ANR, ANR-20-COVI-000, #ANR-10-COHO-06), Fondation pour la Recherche Médicale (#20RR052-00), Institut National de la Santé et de la Recherche Médicale (Inserm, C20-26). We acknowledge financial support from the Investissement d'Avenir programme, the Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases programme (grant ANR-10-LABX-62-IBEID), Santé Publique France, the INCEPTION project (PIA/ANR-16-CONV-0005), the EU Horizon 2020 research and innovation programme under grants 101003589 (RECOVER) and 874735 (VEO), AXA, and Groupama. The CONSTANCES Cohort Study is supported by the Caisse Nationale d'Assurance Maladie, the French Ministry of Health, the Ministry of Research, and Inserm. CONSTANCES benefits from a grant from the French National Research Agency (grant number ANR-11-INBS-0002) and is also partly funded by Merck Sharp & Dohme, AstraZeneca, Lundbeck, and L'Oreal. The E3N-E4N cohort is supported by the following institutions: Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation, Inserm, University Paris-Saclay, Gustave Roussy, the Mutuelle générale de l'Éducation nationale, and the French League Against Cancer. The NutriNet-Santé study is supported by the following public institutions: Ministère de la Santé, Santé Publique France, Inserm, Institut National de la Recherche Agronomique, Conservatoire National des Arts et Métiers, and Sorbonne Paris Nord. The CEPH-Biobank is supported by the Ministère de l'Enseignement Supérieur, de la Recherche et de l'Innovation., ANR-10-COHO-0006,E4N,Etude Epidémiologique des Enfants de femmes de l'Education Nationale(2010), ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), ANR-16-CONV-0005,INCEPTION,Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs(2016), European Project: 101003589, H2020-SC1-PHE-CORONAVIRUS-2020,RECOVER(2020), European Project: 874735,VEO, Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Collège Doctoral, Università degli Studi di Firenze = University of Florence (UniFI), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Cohortes épidémiologiques en population (CONSTANCES), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Université Paris Cité (UPCité), European Project: 874735,H2020-SC1-2019-Single-Stage-RTD,VEO(2020), Salje, Henrik [0000-0003-3626-4254], Apollo - University of Cambridge Repository, Gestionnaire, HAL Sorbonne Université 5, Cohortes - Etude Epidémiologique des Enfants de femmes de l'Education Nationale - - E4N2010 - ANR-10-COHO-0006 - COHO - VALID, Integrative Biology of Emerging Infectious Diseases - - IBEID2010 - ANR-10-LABX-0062 - LABX - VALID, Institut Convergences pour l'étude de l'Emergence des Pathologies au Travers des Individus et des populatiONs - - INCEPTION2016 - ANR-16-CONV-0005 - CONV - VALID, Rapid European COVID-19 Emergency Response research - RECOVER - - H2020-SC1-PHE-CORONAVIRUS-20202020-02-14 - 2022-02-13 - 101003589 - VALID, and Versatile Emerging infectious disease Observatory - VEO - - H2020-SC1-2019-Single-Stage-RTD2020-01-01 - 2024-12-31 - 874735 - VALID
Subjects: Adult, Models, Statistical, COVID-19, Articles, Middle Aged, Hospitalization, Young Adult, Age Distribution, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Seroepidemiologic Studies, Humans, Public Health Surveillance, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, Aged
Abstract: BACKGROUND: Regional monitoring of the proportion of the population who have been infected by SARS-CoV-2 is important to guide local management of the epidemic, but is difficult in the absence of regular nationwide serosurveys. We aimed to estimate in near real time the proportion of adults who have been infected by SARS-CoV-2. METHODS: In this modelling study, we developed a method to reconstruct the proportion of adults who have been infected by SARS-CoV-2 and the proportion of infections being detected, using the joint analysis of age-stratified seroprevalence, hospitalisation, and case data, with deconvolution methods. We developed our method on a dataset consisting of seroprevalence estimates from 9782 participants (aged ≥20 years) in the two worst affected regions of France in May, 2020, and applied our approach to the 13 French metropolitan regions over the period March, 2020, to January, 2021. We validated our method externally using data from a national seroprevalence study done between May and June, 2020. FINDINGS: We estimate that 5·7% (95% CI 5·1-6·4) of adults in metropolitan France had been infected with SARS-CoV-2 by May 11, 2020. This proportion remained stable until August, 2020, and increased to 14·9% (13·2-16·9) by Jan 15, 2021. With 26·5% (23·4-29·8) of adult residents having been infected in Île-de-France (Paris region) compared with 5·1% (4·5-5·8) in Brittany by January, 2021, regional variations remained large (coefficient of variation [CV] 0·50) although less so than in May, 2020 (CV 0·74). The proportion infected was twice as high (20·4%, 15·6-26·3) in 20-49-year-olds than in individuals aged 50 years or older (9·7%, 6·9-14·1). 40·2% (34·3-46·3) of infections in adults were detected in June to August, 2020, compared with 49·3% (42·9-55·9) in November, 2020, to January, 2021. Our regional estimates of seroprevalence were strongly correlated with the external validation dataset (coefficient of correlation 0·89). INTERPRETATION: Our simple approach to estimate the proportion of adults that have been infected with SARS-CoV-2 can help to characterise the burden of SARS-CoV-2 infection, epidemic dynamics, and the performance of surveillance in different regions. FUNDING: EU RECOVER, Agence Nationale de la Recherche, Fondation pour la Recherche Médicale, Institut National de la Santé et de la Recherche Médicale (Inserm).
Published: 2021

297. Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis

Author: Mori, Nagisa, primary, Keski-Rahkonen, Pekka, additional, Gicquiau, Audrey, additional, Rinaldi, Sabina, additional, Dimou, Niki, additional, Harlid, Sophia, additional, Harbs, Justin, additional, Van Guelpen, Bethany, additional, Aune, Dagfinn, additional, Cross, Amanda J, additional, Tsilidis, Konstantinos K, additional, Severi, Gianluca, additional, Kvaskoff, Marina, additional, Fournier, Agnès, additional, Kaaks, Rudolf, additional, Fortner, Renée Turzanski, additional, Schulze, Matthias B, additional, Jakszyn, Paula, additional, Sánchez, Maria-Jose, additional, Colorado-Yohar, Sandra M, additional, Ardanaz, Eva, additional, Travis, Ruth, additional, Watts, Eleanor L, additional, Masala, Giovanna, additional, Krogh, Vittorio, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Panico, Salvatore, additional, Bueno-de-Mesquita, Bas, additional, Gram, Inger Torhild, additional, Waaseth, Marit, additional, Gunter, Marc J, additional, and Murphy, Neil, additional
Published: 2021
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298. The blood metabolome of incident kidney cancer: A case–control study nested within the MetKid consortium

Author: Guida, Florence, primary, Tan, Vanessa Y., additional, Corbin, Laura J., additional, Smith-Byrne, Karl, additional, Alcala, Karine, additional, Langenberg, Claudia, additional, Stewart, Isobel D., additional, Butterworth, Adam S., additional, Surendran, Praveen, additional, Achaintre, David, additional, Adamski, Jerzy, additional, Amiano, Pilar, additional, Bergmann, Manuela M., additional, Bull, Caroline J., additional, Dahm, Christina C., additional, Gicquiau, Audrey, additional, Giles, Graham G., additional, Gunter, Marc J., additional, Haller, Toomas, additional, Langhammer, Arnulf, additional, Larose, Tricia L., additional, Ljungberg, Börje, additional, Metspalu, Andres, additional, Milne, Roger L., additional, Muller, David C., additional, Nøst, Therese H., additional, Pettersen Sørgjerd, Elin, additional, Prehn, Cornelia, additional, Riboli, Elio, additional, Rinaldi, Sabina, additional, Rothwell, Joseph A., additional, Scalbert, Augustin, additional, Schmidt, Julie A., additional, Severi, Gianluca, additional, Sieri, Sabina, additional, Vermeulen, Roel, additional, Vincent, Emma E., additional, Waldenberger, Melanie, additional, Timpson, Nicholas J., additional, and Johansson, Mattias, additional
Published: 2021
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299. A New Pipeline for the Normalization and Pooling of Metabolomics Data

Author: Viallon, Vivian, primary, His, Mathilde, additional, Rinaldi, Sabina, additional, Breeur, Marie, additional, Gicquiau, Audrey, additional, Hemon, Bertrand, additional, Overvad, Kim, additional, Tjønneland, Anne, additional, Rostgaard-Hansen, Agnetha Linn, additional, Rothwell, Joseph A., additional, Lecuyer, Lucie, additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Johnson, Theron, additional, Schulze, Matthias B., additional, Palli, Domenico, additional, Agnoli, Claudia, additional, Panico, Salvatore, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Verschuren, W. M. Monique, additional, Engelfriet, Peter, additional, Onland-Moret, Charlotte, additional, Vermeulen, Roel, additional, Nøst, Therese Haugdahl, additional, Urbarova, Ilona, additional, Zamora-Ros, Raul, additional, Rodriguez-Barranco, Miguel, additional, Amiano, Pilar, additional, Huerta, José Maria, additional, Ardanaz, Eva, additional, Melander, Olle, additional, Ottoson, Filip, additional, Vidman, Linda, additional, Rentoft, Matilda, additional, Schmidt, Julie A., additional, Travis, Ruth C., additional, Weiderpass, Elisabete, additional, Johansson, Mattias, additional, Dossus, Laure, additional, Jenab, Mazda, additional, Gunter, Marc J., additional, Lorenzo Bermejo, Justo, additional, Scherer, Dominique, additional, Salek, Reza M., additional, Keski-Rahkonen, Pekka, additional, and Ferrari, Pietro, additional
Published: 2021
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300. Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Author: Aglago, Elom K., primary, Mayén, Ana-Lucia, additional, Knaze, Viktoria, additional, Freisling, Heinz, additional, Fedirko, Veronika, additional, Hughes, David J., additional, Jiao, Li, additional, Eriksen, Anne Kirstine, additional, Tjønneland, Anne, additional, Boutron-Ruault, Marie-Christine, additional, Rothwell, Joseph A., additional, Severi, Gianluca, additional, Kaaks, Rudolf, additional, Katzke, Verena, additional, Schulze, Matthias B., additional, Birukov, Anna, additional, Palli, Domenico, additional, Sieri, Sabina, additional, Santucci de Magistris, Maria, additional, Tumino, Rosario, additional, Ricceri, Fulvio, additional, Bueno-de-Mesquita, Bas, additional, Derksen, Jeroen W. G., additional, Skeie, Guri, additional, Gram, Inger Torhild, additional, Sandanger, Torkjel, additional, Quirós, J. Ramón, additional, Luján-Barroso, Leila, additional, Sánchez, Maria-Jose, additional, Amiano, Pilar, additional, Chirlaque, María-Dolores, additional, Gurrea, Aurelio Barricarte, additional, Johansson, Ingegerd, additional, Manjer, Jonas, additional, Perez-Cornago, Aurora, additional, Weiderpass, Elisabete, additional, Gunter, Marc J., additional, Heath, Alicia K., additional, Schalkwijk, Casper G., additional, and Jenab, Mazda, additional
Published: 2021
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