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Forty children between ages 6 and 8 were administered a set of spatial perspective tasks. On half of the items, children responded by rotating a duplicate of the target display; on the remainder, children reconstructed the displays to correspond to a perspective view. The displays differed as to whether they contained marked or unmarked objects. On the basis of an information-processing analysis of these tasks, we predicted that the response-type variables and stimulus variables would interact in known ways. Analysis of variance results revealed a good fit with the hypothesized outcomes. Main effects were detected for age, which favored older children, and for display, which favored unmarked objects; the rotation task proved easier. Significant interactions revealed that task demands increasing task difficulty were more problematic in the construction task than in the rotation task, as predicted.

The gross and microscopic appearance of the hearts from eight patients with Duchenne's progressive muscular dystrophy are described. Seven hearts had gross evidence of myocardial fibrosis, five of these demonstrating distinctive fibrosis of the epimyocardial portion of the free wall of the left ventricle, often with a striking band-like appearance. On the basis of mapping studies of the myocardial fibrosis, a theory regarding the progression of myocardial fibrosis in Duchenne's progressive muscular dystrophy is presented. Correlation of the pathologic anatomy, electrocardiograms, and vectorcardiograms in these patients and the family studies of others suggests that Duchenne's progressive muscular dystrophy represents a generalized cardiomyopathy that has its gravest and most distinctive effect on the epimyocardial portion of the free wall of the left ventricle.

To assess the differential salience of geometric features embedded in spatial displays, 60 preschool children, 3 to 5 years old, were required to reconstruct a series of geometric displays. Each arrangement included the depiction of a topological feature, unconnectedness; a Euclidean feature, linearity; and a projective feature, orientation. Children built their reconstructions under two demand conditions. The reconstructions were scored for the number that preserved each of the different geometric features. Results from a mixed-design analysis of variance revealed main effects for age, demand condition, and geometric feature, as well as for several first-order interactions. Data indicated that the Euclidean feature was the most salient and most frequently preserved characteristic and that the topological and projective ones were more problematic. The findings were discussed as a contrast to Piagetian predictions.

Measurements of small oscillatory deformations of a fibrin clot by axial motion of a rod in a closed tube reveal an anomalous mechanical loss due to permeation of fluid through the clot structure. The Darcy constant for permeation can be calculated from data at the frequency where the apparent storage and loss shear moduli are equal, without the necessity of measurements at much lower frequencies as previously employed. From the Darcy constant, the average number of fibrin monomer units (v) per cross-section of a fibrous element of the clot can be calculated; it ranges from 4 to several hundred. In the range of fibrin concentration(c) from 3 to 14 milligrams, v is approximately proportional to c-2 for clots of coarse structure and to c-0.5 for clots of fine structure.

Global measures of illness are designed to measure the performance of a health service as a whole and the contribution of its various components. Such measures convert data about the outcome of medical care into information for use in planning at all administrative levels including the highest levels of government. This is achieved by means of a classification of states of illness applicable to all patients, whatever their diagnosis and symptoms, and of a scale which places valuations as perceived by society on the defined states. The valuations of changes in the states of individuals during treatment or over a period of time can then be summed for heterogeneous populations. By adjusting the valuations of future changes for time preferences it may be possible to take into account prognosis, and by placing a valuation on death, mortality and morbidity data can be combined. The properties appropriate to the classification and scale are defined and problems encountered in their derivation are discussed. Examples are presented of the application of one global measure to a group of medical specialists and to population data for the United Kingdom.