287 results on '"Robert Carlson"'
Search Results
252. The Application of Functional Dependency Theory to Relational Databases
- Author
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C. Robert Carlson, Adarsh K. Arora, and Miroslava Milosavljevic Carlson
- Subjects
Information retrieval ,Relational calculus ,General Computer Science ,Computer science ,Relational database ,View ,Relational model ,Database schema ,Database theory ,Database design ,Database model - Abstract
This paper examines three areas where the application of functional dependency theory to relational databases has had an impact. These areas are relational views, database translation and logical database design. The paper refines our earlier work on relational views in which the concepts of consistent and updatable views were proposed. In the area of database translation, it identifies six levels of information preserving relational transformations. Finally, a relational database design algorithm is proposed which combines the best features of the classical synthesis and decomposition approaches while avoiding their identified shortcomings. INTRODUCTION This paper shows, that functional dependency theory provides a unified framework for the analysis of several database problems. The paper represents both a synthesis and extension of our earlier work on each of these problems. The first section contains background infor- mation to familiarize the reader with the terminology and concepts of functional dependency theory. In the second section, functional dependencies are used to define the concepts of consistent and updatable views. Basically, a 'consistent view' is one whose interpretation is consistent with that of the underlying database. An 'updatable view' is one whose updates can be translated into appropriate updates of the underlying database. Together, these definitions describe a class of useable views. In section three, six levels of information preserving relational transformations are identified. These levels reflect the different degrees with which transformations preserve the update and retrieval properties of databases. These levels are important since previously many applications have mistakenly assumed that all the information embodied in their database is preserved by the restructuring operations they have employed. Finally, some shortcomings of the classical synthesis and decomposition approaches to relationship database design are identified in the fourth section. A new algorithm is then proposed which combines the best features of these approaches while avoiding their iden- tified shortcomings.
- Published
- 1982
253. Self-assessment procedure V
- Author
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Peter Scheuermann and C. Robert Carlson
- Subjects
Self-assessment ,General Computer Science ,Database ,Computer science ,computer.software_genre ,computer - Published
- 1978
254. A Simple Pre‐Exposure Treatment to Improve Post‐Develop Photoresist Step Coverage
- Author
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Venkat Nagaswami and Robert Carlson
- Subjects
Exposure treatment ,Renewable Energy, Sustainability and the Environment ,Chemistry ,Materials Chemistry ,Electrochemistry ,Physical chemistry ,Nanotechnology ,Photoresist ,Condensed Matter Physics ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials - Abstract
Description d'un traitement de pre-exposition du photoresist de type-AZ depose sur les pastilles qui ameliore le recouvrement apres developpement en inhibant la vitesse de dissolution du photoresist non expose. La pre-exposition consiste a immerger les pastilles recouvertes de photoresist et recuites dans une base faiblement alcaline telle que le developpant 5:1 AZ 351. Explication par la formation d'azoique
- Published
- 1984
255. Structural locking mechanisms and their effect on database management system performance
- Author
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C. Robert Carlson and Cory Devor
- Subjects
Database ,Computer science ,Distributed computing ,computer.software_genre ,Database design ,Database tuning ,Database testing ,Consistency (database systems) ,Concurrency control ,Centralized database ,Relational database management system ,Hardware and Architecture ,Database theory ,computer ,Database transaction ,Software ,Information Systems - Abstract
Database management systems must provide a concurrency control subsystem to protect database consistency in the presence of concurrent readers and writers. The widely accepted method for realizing such protection in centralized database management systems is through a locking mechanism. The design of a locking mechanism for a relational database management systems presents the developer with a considerable number of new alternatives. This paper discusses some of those alternatives and their tradeoffs. A particular model is then presented which supports these alternatives for relational database management system locking mechanisms. A simulation model is described which was used to provide experimental results investigating these design alternatives. Results from a number of simulation experiments are presented demonstrating the effects on performance realized under different locking mechanism designs and transaction behavior profiles.
- Published
- 1982
256. Clarification of the reinvestment assumption in capital analysis
- Author
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C. Robert Carlson, Donald H. Wort, and Michael L. Lawrence
- Subjects
Marketing ,Public economics ,Capital (economics) ,Economics ,Classical economics - Published
- 1974
257. Computer Technology for Exercise and Sport Pedagogy: Recording, Storing, and Analyzing Interval Data
- Author
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Thomas L. McKenzie and B. Robert Carlson
- Subjects
Interval data ,Sport Pedagogy ,Multimedia ,Physical Therapy, Sports Therapy and Rehabilitation ,Orthopedics and Sports Medicine ,Psychology ,computer.software_genre ,computer ,Education ,Computer technology ,Physical education - Published
- 1984
258. The dimensionality of the PRCA‐24: An explication of context dimensions
- Author
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B. Robert Carlson, Stephen W. King, and Janis F. Andersen
- Subjects
Structure (mathematical logic) ,Linguistics and Language ,Context effect ,Communication ,Single factor ,Assessment instrument ,Context (language use) ,computer.software_genre ,Language and Linguistics ,Education ,Explication ,Data mining ,Psychology ,computer ,Cognitive psychology ,Curse of dimensionality - Abstract
This article empirically addresses the dimensional structure of the PRCA‐24. Data from 656 respondents were factor analyzed and yielded inconclusive results for the most appropriate dimensional structure. The single factor solution most commonly espoused was viable; however, four specific characteristics of the data suggested an alternative underlying structure. An analysis of individual subject's patterns of context‐specific subscores revealed an interesting context effect that argues for treating the PRCA‐24 as a four dimensional assessment instrument.
- Published
- 1988
259. Human Values and Cocaine Use
- Author
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William H. Edwards and B. Robert Carlson
- Subjects
Adult ,Male ,Health (social science) ,Adolescent ,Social Values ,Substance-Related Disorders ,Medicine (miscellaneous) ,Human values ,Social value orientations ,Sex Factors ,Cocaine ,Cocaine users ,medicine ,Humans ,Illegal drug use ,Activity profile ,Public Health, Environmental and Occupational Health ,General Medicine ,medicine.disease ,Substance abuse ,Psychiatry and Mental health ,Cocaine use ,Female ,Psychology ,Value (mathematics) ,Clinical psychology - Abstract
The purpose of this study was to examine the relationship between prioritized rankings of human values among persons who either use or do not use cocaine. Three hundred eighty-three college-aged subjects were given the Wellness Activity Profile, a questionnaire that yielded data on cocaine use and human values. Discriminant analyses indicated that the value profiles of cocaine and non-cocaine users were significantly different for both males and females. The results support the contention that dominant value orientations differ between those using cocaine and those abstaining. Personal values are more important to users, while social values are more important to non-users. Results of the study suggested that prevailing theories informing educational and treatment protocols need to account for value structures that discriminate cocaine users from non-users.
- Published
- 1987
260. Demographic Variables and Recreational Substance Use among College Students
- Author
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Jaime L. Davis and B. Robert Carlson
- Subjects
Adult ,Male ,Health (social science) ,Psychometrics ,Higher education ,Medicine (miscellaneous) ,Marijuana Smoking ,Family income ,Developmental psychology ,Cocaine ,medicine ,Humans ,Personality test ,Students ,Recreation ,business.industry ,Politics ,Public Health, Environmental and Occupational Health ,General Medicine ,Achievement ,medicine.disease ,Substance abuse ,Psychiatry and Mental health ,Income ,Female ,Substance use ,Psychology ,business - Abstract
The purpose of this study was to examine the relationship between demographic variables and recreational substance use within the college population. Eight hundred thirty-two college-aged students were given the Wellness Activity Profile, a questionnaire that includes sections yielding demographic and recreational substance usage data. Discriminant analyses of the data indicated that persons using recreational substances differed significantly from non-users. Marijuana users differed from non-users on parental income, high school grade point average, gender, and political orientation, while no demographic differences were found between cocaine users and non-users. Composite substance users differed from non-users on political orientation, parental income, and gender.
- Published
- 1988
261. Local completeness for eigenfunctions of regular maximal ordinary differential operators
- Author
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Robert Carlson
- Subjects
Constant coefficients ,Applied Mathematics ,General Mathematics ,Hilbert space ,Spectral theorem ,Operator theory ,Differential operator ,Fourier integral operator ,Combinatorics ,symbols.namesake ,Operator (computer programming) ,symbols ,Algebraic differential equation ,Mathematics - Abstract
Let L = ∑ m = 0 n A m ( x ) D m L = \sum \nolimits _{m = 0}^n {{A_m}(x){D^m}} be a differential operator on ⊕ k L 2 [ 0 , 1 ] { \oplus ^k}{L^2}[0,1] with infinitely differentiable k × k k \times k matrix valued coefficients. Assume that det A n ( x ) ≠ 0 \det \,{A_n}(x) \ne 0 for x ∈ [ 0 , 1 ] x \in [0,1] . The domain of L is the set of k-vector valued functions f such that f ∈ C n − 1 ( [ 0 , 1 ] ) , f ( n − 1 ) f \in {C^{n - 1}}([0,1]),{f^{(n - 1)}} is absolutely continuous on [0, 1] and L f ∈ ⊕ k L 2 [ 0 , 1 ] Lf \in { \oplus ^k}{L^2}[0,1] . Let x 0 ∈ ( 0 , 1 ) {x_0} \in (0,1) . Then there is a neighborhood U ( x 0 ) U({x_0}) containing x 0 {x_0} such that the restrictions of the eigenfunctions of L to U ( x 0 ) U({x_0}) have dense span in ⊕ k L 2 [ U ( x 0 ) ] { \oplus ^k}{L^2}[U({x_0})] . The example L = e − i x d / d x L = {e^{ - ix}}d/dx shows that this is the best possible abstract result.
- Published
- 1980
262. THE COST OF CAPITAL AS A WEIGHTED AVERAGE
- Author
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C. Robert Carlson and Timothy J. Nantell
- Subjects
Economics and Econometrics ,Leverage (finance) ,Capital structure ,Maximization ,Weighting ,Microeconomics ,Marginal cost of capital schedule ,Cost of capital ,Accounting ,Economics ,Weighted average return on assets ,Mathematical economics ,Weighted arithmetic mean ,Finance - Abstract
IN RESEARCH, teaching, and application we have found it convenient for some time now to compute the cost of capital as a weighted average of the costs of the various sources of capital. This entire notion, though, that the true cost of capital can be computed as a weighted average of the component costs has recently been questioned. Reilly and Wecker [9] show us that the conditions under which Solomon [10] first formally developed the weighted-average approach to the cost of capital are rather restrictive. Linke and Kim [6] and Ezzell and Porter [2] argue that these restrictions as to cash-flow patterns are not necessary and that a weighting approach to computing the cost of capital is valid as long as the firm's leverage position is maintained. In addition to these discussions on the general validity of the weighting procedure as a computational device, other arguments have focused on the validity of the particular formulations utilized. Specifically, three interrelated issues have been raised. First, Haley and Schall [3, pp. 298-304] imply and Arditti [1] states flatly that the traditional method of weighting in an after-tax cost of debt is incorrect. Secondly, these same authors feel that once the cost of debt is correctly specified on a beforetax basis, the resultant weighted-average cost of capital, as a function of the firm's capital structure, is not minimized at the point of value maximization. Finally, Ezzell and Porter [2], Arditti [1, p. 1004, footnote 4], and Haley and Schall [3, pp. 304-313] imply that the weighted-average figure utilizing the so-called correctly specified (before-tax) cost of debt may not be usable as a cutoff rate in making investment decisions. It is the contention of this paper that the arguments offered in support of these criticisms are misleading. Most of the confusion generated by this literature results from the failure to recognize that even with a generally accepted definition of the true cost of capital, innumerable specifications of this definition, all equally valid, are possible. Two such specifications of the true cost of capital definition are developed in Section II. For each specification, two corresponding weighted-average costs of capital are formulated. One is less general than the other in the sense that it requires conditions necessary for Modigliani and Miller's [7] capital structure propositions.1 An important conclusion of this section is that as weighted-average formulations of a single definition, there is no basis upon which to identify any
- Published
- 1975
263. Grassmannian subvarieties arising in the spectral theory of ordinary differential operators
- Author
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Robert Carlson and Robert Varley
- Subjects
Pure mathematics ,Spectral theory ,Applied Mathematics ,General Mathematics ,Grassmannian ,Differential operator ,Mathematics - Published
- 1980
264. Evaluating the Teacher-Adviser
- Author
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Ted Mable and Robert Carlson
- Subjects
Medical education ,Harm ,Pedagogy ,Evaluation methods ,Program development ,Psychology ,Education - Abstract
Evaluation, the authors warn, if not carefully planned and implemented, can do more harm than good. In the following article they describe a successful sys tem used to monitor one recent educational innova tion.
- Published
- 1976
265. A Diagnosis and Remediation Plan for Physical Education for the Handicapped
- Author
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B. Robert Carlson
- Subjects
Medical education ,Pedagogy ,Plan (drawing) ,Psychology ,Physical education - Published
- 1972
266. Isotonic Strength and Relative Isotonic Endurance
- Author
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B. Robert Carlson
- Subjects
Adult ,Male ,medicine.medical_specialty ,business.industry ,Experimental and Cognitive Psychology ,Isometric exercise ,Flexor muscles ,Sensory Systems ,Future study ,Physical medicine and rehabilitation ,medicine.anatomical_structure ,Forearm ,Physical Fitness ,Isotonic ,Humans ,Medicine ,business ,Muscle group ,Muscle Contraction - Abstract
Summary.-No relationship was found between isotonic strength and relative isotonic endurance. Additional support was provided by the insignificant results in the analysis of the endurance performance of the three groups based on strength level. Implications for the use of relative isotonic endurance tests in future study of perseverance were discussed. The component of physical fitness known as muscular endurance has been the subject of numerous laboratory investigations. Tests of absolute and relative endurance (2, 4, 14, 15, 18) as well as repeated contractions (10, 13) have been used to measure isometric endurance. The bulk of the laboratory studies of isotonic endurance, however, have included measurement with a type of ergograph (5, 6, 7, 11, 17). The testing procedure with this apparatus has incl~lded a test of strength upon which the weight load for the endurance test was determined. The relative loading procedure for isotonic endurance has usually been based on an isometric strength test. Relationships between isometric strength and relative isotonic endurance have been defined. In light of a recent study by Carlson (3), the absolute value of such relationships is questionable. Acknowledging the observed differences between isometric and isotonic strength, the relationship between isotonic strength and relative isotonic endurance appears to be of greater importance. The purpose of this study, therefore, was to examine the relationship between isotonic strength and relative isotonic endurance. In the ergographic studies by Clarke (5, 6, 7), a test of isometric strength was given to determine the strength of the muscle group to be tested, and the resistance used for the endurance test was a percentage of this strength. Clarke used three-eighths of the strength for the resistance in testing the endurance of the flexor muscles of the forearm and five-eighths of the strength in the studies of the flexor muscles of the arm. These percentages were selected because they induced exhaustion in a relatively short period of time. Different percentages have also been used. Walters, et al. (17) used one-third of the strength of the flexor muscles of the forearm of the preferred arm. McCraw and Burnham (12) used 50% of the isometric strength of the flexor muscles of the upper arm and extensor muscles of the forearm to test isotonic endurance of these muscle groups. Twenty-five per cent of the isometric strength of the extensor muscles of the lower leg and thigh was used by McCraw and Burnham to assess isotonic endurance of these muscle groups. Mathews and Kruse ('11) used
- Published
- 1970
267. Status of Research on Children with Perceptual-Motor Dysfunction
- Author
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B. Robert Carlson
- Subjects
medicine.medical_specialty ,Perceptual motor ,medicine ,Audiology ,Psychology - Published
- 1972
268. Relative Isometric Endurance and Different Levels of Athletic Achievement
- Author
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B. Robert Carlson
- Subjects
Physical development ,Engineering ,medicine.medical_specialty ,Physical medicine and rehabilitation ,business.industry ,medicine ,Physical therapy ,Pharmacology (medical) ,Analysis of variance ,Isometric exercise ,business ,Physical strength - Abstract
Relative isometric endurance tests of 50, 60, 70, and 80 percent weight loads were used to evaluate the muscular endurance of three groups of male college students. The 47 students were grouped according to level of athletic achievement. Analysis of variance models failed to detect any differences between the endurance of the three groups. Consideration was given to the use of relative endurance tests for evaluating levels of motivation.
- Published
- 1969
269. The Use of Analysis of Variance in Estimating Reliability of Isometric Elbow Flexion Strength
- Author
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Walter Kroll and B. Robert Carlson
- Subjects
Intraclass correlation ,Statistics ,Degrees of freedom (statistics) ,Pharmacology (medical) ,Isometric exercise ,Analysis of variance ,Variance (accounting) ,Elbow flexion ,Physical strength ,Psychology ,Reliability (statistics) - Abstract
Thirty-six male college students served as subjects in a study to determine the reliability of isometric strength assessment of the right elbow flexor muscles by means of an intraclass correlation technique and to estimate reliability one might obtain under similar conditions with different combinations of days and trials. An analysis of variance treatment by subjects design was used to obtain the estimates of error necessary for calculation of the estimate of reliability. Some consideration was given to the effect of degrees of freedom on negative estimates of variance.
- Published
- 1970
270. Isometric Strength and Relative Isometric Endurance
- Author
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Lynn W. McCraw and B. Robert Carlson
- Subjects
medicine.medical_specialty ,Physical medicine and rehabilitation ,Right forearm ,business.industry ,Medicine ,Pharmacology (medical) ,Isometric exercise ,Analysis of variance ,Flexor muscles ,business ,Physical strength - Abstract
Thirty-six male college students served as subjects in a study that examined the relationship between isometric strength and relative isometric endurance of the right forearm flexor muscles. The percentages of maximum isometric strength used for the endurance tests were 30, 45, 60, and 75. Three equal groups were formed based on the strength level of the subjects, and an analysis of variance test was used to determine the existence of significant differences. Significant negative correlations were found between isometric strength and relative isometric endurance. The weak subjects performed significantly better than the strong subjects on the light weight loads, with no difference existing between the endurance performances on the heavy loads.
- Published
- 1971
271. Genericity of simple eigenvalues
- Author
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Robert Carlson
- Subjects
Matrix differential equation ,Pure mathematics ,Simple (abstract algebra) ,Spectrum of a matrix ,ComputingMethodologies_SYMBOLICANDALGEBRAICMANIPULATION ,MathematicsofComputing_NUMERICALANALYSIS ,Mathematics::Spectral Theory ,Differential operator ,Eigenvalues and eigenvectors ,Analysis ,Mathematics - Abstract
Simple eigenvalues are shown to be generic in several senses for regular ordinary differential operators.
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- View/download PDF
272. Rapid fabrication of microchannels using microscale plasma activated templating (μPLAT) generated water moldsElectronic supplementary information (ESI) available: Details of modularized fabrication and Fig. S1. See DOI: 10.1039/b618269k.
- Author
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Shih-hui Chao, Robert Carlson, and Deirdre R. Meldrum
- Subjects
- *
MICROFLUIDICS , *SOLID freeform fabrication , *PHOTOLITHOGRAPHY , *PHOTORESISTS - Abstract
Poly(dimethylsiloxane) (PDMS) is a common material used in fabricating microfluidic devices. The predominant PDMS fabrication method, soft lithography, relies on photolithography for fabrication of micropatterned molds. In this technical note, we report an alternative molding technique using microscale PLasma Activated Templating (μPLAT). The use of photoresist in soft lithography is replaced by patterned water droplets created using μPLAT. When liquid PDMS encapsulates patterned water and then solidifies, the cavities occupied by water become structures such as microchannels. Using this method, device fabrication is less time consuming, more cost efficient and flexible, and ideal for rapid prototyping. An additional important feature of the water-molding process is that it yields structural profiles that are difficult to achieve using photolithography. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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- View/download PDF
273. Narrative connectives in Sùpyìré
- Author
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Robert Carlson
- Published
- 1987
274. Assessment of motor ability of selected deaf children in Kansas
- Author
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B. Robert Carlson
- Subjects
Male ,medicine.medical_specialty ,Hearing loss ,education ,Poison control ,Experimental and Cognitive Psychology ,Audiology ,Deafness ,Special education ,03 medical and health sciences ,0302 clinical medicine ,Sex Factors ,Hearing ,Injury prevention ,Task Performance and Analysis ,otorhinolaryngologic diseases ,medicine ,Humans ,Child ,Motor skill ,Anthropometry ,05 social sciences ,Age Factors ,050301 education ,Human factors and ergonomics ,030229 sport sciences ,Kansas ,Child development ,Sensory Systems ,Test (assessment) ,Motor Skills ,Physical Fitness ,Education, Special ,Physical therapy ,Female ,medicine.symptom ,Psychology ,0503 education - Abstract
48 residential students at the Kansas State School for the Deaf were given the Brace Motor Ability Test. Sex had little influence on the levels of performance, while age below 7 yr. yielded significantly lower performance. The extent of hearing loss did not influence the performance.
- Published
- 1972
275. Thomson Township Spotlight, Volume 3, Number 9, Thomson High School, Esko, Minnesota
- Author
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Helberg, Jennie; Otto, Kirk; Juntti, Clarence; Ware, Verna; Bergstedt, Mildred; Tan, Helen; Tan, Robert; Carlson, Clarence; Kesti, Sylvia; Juntunen, Rosalie; Anderson, Fern; Koivisto, Esther; Polo, Esther; Kommes; Ethel; Seglem, C.; Heino, Vienna, Thomson Township High School, Helberg, Jennie; Otto, Kirk; Juntti, Clarence; Ware, Verna; Bergstedt, Mildred; Tan, Helen; Tan, Robert; Carlson, Clarence; Kesti, Sylvia; Juntunen, Rosalie; Anderson, Fern; Koivisto, Esther; Polo, Esther; Kommes; Ethel; Seglem, C.; Heino, Vienna, and Thomson Township High School
- Abstract
Esko played host for the subdistrict basketball tournament at the Thomson Township High School Gymnasium. Due to high snow banks and barely passable roads, cessation of after school extra curricular activities was made necessary. Educational films were shown during lunch hour at both Washington and Lincoln Schools, sanctioned by the school board at a special meeting. Superintendent A. L. Winterquist wrote an article about the basketball tournament. Commercial students did well in dictation and typing speed tests. The advanced home economics class took a field trip to view an exhibit of wood etchings and carvings brought from New York to the Cloquet High School. Washington's birthday was observed by a program at which Cloquet attorney Mr. Evelyn McKenna spoke and Lauren Hiukka played his accordion. A page was dedicated to information about pottery and glassware. Evening classes in home economics were underway, with ten women studying clothing selection and dressmaking. Eighteen men were taking evening classes in industrial and agriculture class. Floodwood's basketball beat Thomson, but Thomson's basketball team beat Meadowlands and McGregor as well as Cromwell's basketball team.
- Published
- 1937
276. Spotlight, Volume 3, Number 11, Thomson High School, Esko, Minnesota
- Author
-
Helberg, Jennie; Otto, Kirk; Juntti, Clarence; Ware, Verna; Bergstedt, Mildred; Tan, Helen; Tan, Robert; Carlson, Clarence; Kesti, Sylvia; Juntunen, Rosalie; Anderson, Fern; Koivisto, Esther; Polo, Esther; Kommes; Ethel; Seglem, C.; Heino, Vienna, Thomson Township High School, Helberg, Jennie; Otto, Kirk; Juntti, Clarence; Ware, Verna; Bergstedt, Mildred; Tan, Helen; Tan, Robert; Carlson, Clarence; Kesti, Sylvia; Juntunen, Rosalie; Anderson, Fern; Koivisto, Esther; Polo, Esther; Kommes; Ethel; Seglem, C.; Heino, Vienna, and Thomson Township High School
- Abstract
Basketball Season closed, with four seniors playing their last game. The Thomson High School band performed a concert. They had played for every home basketball game. Student Kirk Otto wrote about the trip to a state safety conference in Minneapolis with Superintendent A. L. Winterquist and Sheriff Luukkonen. Mr. B. M. Winkleman of the Duluth Business University gave a talk to the student body, sponsored by the commercial students. Services conducted in English were advertised at the Finnish Apostolic Lutheran Church. Superintendent A. L. Winterquist wrote an article promoting the library. Over a page was devoted to pastry, with several recipes given. A page was devoted to a summary of the twenty sixth district basketball tournament, where Thomson-Carlton were subdistrict champs. Among news items was an item noting that basketball members were dinner guests at the Lincoln Teacherage.
- Published
- 1937
277. Southdale Library One Millionth Circulation and Exterior
- Author
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Rohlf, Robert; Carlson, Dave (Video Production), Hennepin County Library, Rohlf, Robert; Carlson, Dave (Video Production), and Hennepin County Library
- Abstract
0:00 - Exterior shots of Southdale Library (winter); 2:45 - One millionth checkout item; 7:03 - Exterior shots of Southdale Library (summer) including front sign. Also see HCLV150.
278. Relationship of Strength Level to the Strength-duration Curve
- Author
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Coleman, Alfred E., primary and Robert Carlson, B., additional
- Published
- 1970
- Full Text
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279. Family Development in Three Generations
- Author
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William T. Liu, Reuben Hill, Nelson Foote, Joan Aldous, Robert Carlson, and Robert MacDonald
- Subjects
Sociology and Political Science - Published
- 1975
280. Expansions Associated with Non-Self-Adjoint Boundary-Value Problems
- Author
-
Robert Carlson
- Subjects
Pure mathematics ,Applied Mathematics ,General Mathematics ,Spectrum (functional analysis) ,Hilbert space ,Eigenfunction ,Differential operator ,symbols.namesake ,Operator (computer programming) ,symbols ,Self-adjoint operator ,Eigenvalues and eigenvectors ,Mathematics ,Resolvent - Abstract
Introduction. Given a differential operator 1 on Dk L2[0, 1] with compact resolvent, there are associated sequences of projections {Pm}j obtained by integrating the resolvent around circles whose radii tend to infinity. The problem of obtaining an eigenfunction expansion associated with LS is just the problem of showing that for each f E ekL2 [0, 1], limm" 11f Pmf ll = 0. The usual technique for establishing such results involves an analysis of the kernel of the resolvent. If the operator is of high order, or one is dealing with a system of equations, this technique becomes unwieldy. We present an abstract approach to these problems which avoids the usual analysis of the resolvent kernel. Denote the orthogonal sum L2[0, 1] EDl. . . *D L2[0, 1] (k summands) by ?k L2[0, 1]. Let D = d/dx. A trivial but useful fact is that the operator e = iD acting componentwise on ek L2[0, 1] is self-adjoint if equipped with the domain of n-tuples (f1, . .. , f,,) of absolutely continuous functions whose derivatives are in L2[0, 1], and such that (fi, . . . , fn)(O) = (fl, fn)(l). Moreover the spectrum of e is {2iTnln E Z}, and each eigenvalue has multiplicity k. We begin by showing that the distribution of eigenvalues for this example is typical for a large class of unbounded operators. Information about the eigenvalue distribution for higher order differential operators is easily obtained by use of the spectral mapping theorem. Fixing notation, we let 69(e) be the domain of the operator X, and a(fD) its spectrum. Denote by C the complex numbers and by C* the Hilbert space adjoint of the operator C5. Finally we remark that many of the basic facts about ordinary differential operators can be found in Goldberg [5].
- Published
- 1979
281. Production of Sulfur Allotropes in Electron Irradiated Jupiter Trojans Ice Analogs.
- Author
-
Ahmed Mahjoub, Michael J. Poston, Jordana Blacksberg, John M. Eiler, Michael E. Brown, Bethany L. Ehlmann, Robert Hodyss, Kevin P. Hand, Robert Carlson, and Mathieu Choukroun
- Subjects
SULFUR ,KUIPER belt ,ASTROCHEMISTRY ,SPECTRAL imaging ,TRANS-Neptunian objects - Abstract
In this paper, we investigate sulfur chemistry in laboratory analogs of Jupiter Trojans and Kuiper Belt Objects (KBOs). Electron irradiation experiments of CH
3 OH–NH3 –H2 O and H2 S–CH3 OH–NH3 –H2 O ices were conducted to better understand the chemical differences between primordial planetesimals inside and outside the sublimation line of H2 S. The main goal of this work is to test the chemical plausibility of the hypothesis correlating the color bimodality in Jupiter Trojans with sulfur chemistry in the incipient solar system. Temperature programmed desorption (TPD) of the irradiated mixtures allows the detection of small sulfur allotropes (S3 and S4 ) after the irradiation of H2 S containing ice mixtures. These small, red polymers are metastable and could polymerize further under thermal processing and irradiation, producing larger sulfur polymers (mainly S8 ) that are spectroscopically neutral at wavelengths above 500 nm. This transformation may affect the spectral reflectance of Jupiter Trojans in a different way compared to KBOs, thereby providing a useful framework for possibly differentiating and determining the formation and history of small bodies. Along with allotropes, we report the production of organo-sulfur molecules. Sulfur molecules produced in our experiment have been recently detected by Rosetta in the coma of 67P/Churyumov–Gerasimenko. The very weak absorption of sulfur polymers in the infrared range hampers their identification on Trojans and KBOs, but these allotropes strongly absorb light at UV and Visible wavelengths. This suggests that high signal-to-noise ratio UV–Vis spectra of these objects could provide new constraints on their presence. [ABSTRACT FROM AUTHOR]- Published
- 2017
- Full Text
- View/download PDF
282. Para Além dos Cursos de Empreendedorismo: estratégia, estrutura e processos na Illinois tech para se tornar uma universidade empreendedora
- Author
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Alexandre Nabil Ghobril, David Baker, Nik Rokop, and Carl Robert Carlson
- Subjects
Educação Empreendedora ,Alinhamento Estratégico ,Processo Educacional ,Aprendizagem Experiencial ,Business ,HF5001-6182 - Abstract
Objetivo: Criar uma nova geração de empreendedores de alto impacto é um dos papéis relevantes de universidades em todo o mundo. Para tal, é necessário não apenas oferecer um conjunto de cursos de empreendedorismo, mas articulá-los com uma estratégia de empreendedorismo e inovação. Método: O método da pesquisa foi o estudo de caso, com o objetivo de apresentar como a Illinois Tech, que declara a educação em empreendedorismo como um valor central em sua missão, desenvolveu e implementou estratégia, estrutura e processos para criar uma forte cultura empreendedora, oferecendo oportunidades para projetos de estudantes em todos os cursos e o tempo todo, através de múltiplos níveis de coordenação. Originalidade/Relevância: A estrutura fornecida inclui laboratórios de inovação, Parque Tecnológico, Centro de Empreendedorismo, Academia de Empreendedorismo, dentre outros comitês e membros da comunidade externa para conectar projetos da Universidade ao ecossistema de empreendedorismo regional. Resultados: O processo baseia-se na construção de uma trajetória que o aluno deve percorrer, de cursos acadêmicos a oportunidades extracurriculares para desenvolver e aplicar seus conhecimentos por meio de competições, eventos do setor e organizações estudantis. Contribuições teóricas/metodológicas: Para os estudantes que querem desenvolver e lançar suas startups, há uma variedade de recursos do campus, de instalações a mentores e acesso a recursos externos. A Illinois Tech também está empenhada em identificar as necessidades de negócios na comunidade e aproximar os alunos com contatos da indústria para atender a essas necessidades, particularmente por meio de parcerias com o programa I-PRO, apoio do corpo docente, centros de carreira e centros de pesquisa.
- Published
- 2020
- Full Text
- View/download PDF
283. A Grammar of Supyire
- Author
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Robert Carlson and Robert Carlson
- Subjects
- Suppire language--Grammar
- Abstract
The series builds an extensive collection of high quality descriptions of languages around the world. Each volume offers a comprehensive grammatical description of a single language together with fully analyzed sample texts and, if appropriate, a word list and other relevant information which is available on the language in question. There are no restrictions as to language family or area, and although special attention is paid to hitherto undescribed languages, new and valuable treatments of better known languages are also included. No theoretical model is imposed on the authors; the only criterion is a high standard of scientific quality. To discuss your book idea or submit a proposal, please contact Birgit Sievert.
- Published
- 1994
284. Facing the Global Challenges of Access to Cancer Medication.
- Author
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Jazieh AR, Al-Saggabi AH, McClung M, Carlson R, Schnipper LE, Eniu A, Blauvelt B, Zafar Y, and Kerr D
- Subjects
- Disease Management, Drug Industry, Global Health, Health Personnel, Humans, Neoplasms therapy, Public Health Surveillance, Delivery of Health Care, Health Services Accessibility, Neoplasms epidemiology
- Published
- 2018
- Full Text
- View/download PDF
285. First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors.
- Author
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Abdul Razak AR, Mau-Soerensen M, Gabrail NY, Gerecitano JF, Shields AF, Unger TJ, Saint-Martin JR, Carlson R, Landesman Y, McCauley D, Rashal T, Lassen U, Kim R, Stayner LA, Mirza MR, Kauffman M, Shacham S, and Mahipal A
- Subjects
- Active Transport, Cell Nucleus drug effects, Adult, Aged, Aged, 80 and over, Biopsy, Drug Administration Schedule, Female, Humans, Hydrazines administration & dosage, Immunohistochemistry, Male, Middle Aged, Neoplasms pathology, Research Design, Reverse Transcriptase Polymerase Chain Reaction, Treatment Outcome, Triazoles administration & dosage, Hydrazines pharmacology, Neoplasms drug therapy, Triazoles pharmacology
- Abstract
Purpose This trial evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy of selinexor (KPT-330), a novel, oral small-molecule inhibitor of exportin 1 (XPO1/CRM1), and determined the recommended phase II dose. Patients and Methods In total, 189 patients with advanced solid tumors received selinexor (3 to 85 mg/m
2 ) in 21- or 28-day cycles. Pre- and post-treatment levels of XPO1 mRNA in patient-derived leukocytes were determined by reverse transcriptase quantitative polymerase chain reaction, and tumor biopsies were examined by immunohistochemistry for changes in markers consistent with XPO1 inhibition. Antitumor response was assessed according Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 guidelines. Results The most common treatment-related adverse events included fatigue (70%), nausea (70%), anorexia (66%), and vomiting (49%), which were generally grade 1 or 2. Most commonly reported grade 3 or 4 toxicities were thrombocytopenia (16%), fatigue (15%), and hyponatremia (13%). Clinically significant major organ or cumulative toxicities were rare. The maximum-tolerated dose was defined at 65 mg/m2 using a twice-a-week (days 1 and 3) dosing schedule. The recommended phase II dose of 35 mg/m2 given twice a week was chosen based on better patient tolerability and no demonstrable improvement in radiologic response or disease stabilization compared with higher doses. Pharmacokinetics were dose proportional, with no evidence of drug accumulation. Dose-dependent elevations in XPO1 mRNA in leukocytes were demonstrated up to a dose level of 28 mg/m2 before plateauing, and paired tumor biopsies showed nuclear accumulation of key tumor-suppressor proteins, reduction of cell proliferation, and induction of apoptosis. Among 157 patients evaluable for response, one complete and six partial responses were observed (n = 7, 4%), with 27 patients (17%) achieving stable disease for ≥ 4 months. Conclusion Selinexor is a novel and safe therapeutic with broad antitumor activity. Further interrogation into this class of therapy is warranted.- Published
- 2016
- Full Text
- View/download PDF
286. Phase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma.
- Author
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Gounder MM, Zer A, Tap WD, Salah S, Dickson MA, Gupta AA, Keohan ML, Loong HH, D'Angelo SP, Baker S, Condy M, Nyquist-Schultz K, Tanner L, Erinjeri JP, Jasmine FH, Friedlander S, Carlson R, Unger TJ, Saint-Martin JR, Rashal T, Ellis J, Kauffman M, Shacham S, Schwartz GK, and Abdul Razak AR
- Subjects
- Administration, Oral, Adolescent, Adult, Aged, Aged, 80 and over, Antineoplastic Agents adverse effects, Antineoplastic Agents pharmacokinetics, Biopsy, Canada, Capsules, Disease Progression, Drug Administration Schedule, Drug Compounding, Fasting blood, Female, Food-Drug Interactions, Humans, Hydrazines adverse effects, Hydrazines pharmacokinetics, Male, Middle Aged, New York City, Pharmaceutical Solutions, Postprandial Period, Sarcoma metabolism, Sarcoma pathology, Soft Tissue Neoplasms metabolism, Soft Tissue Neoplasms pathology, Tablets, Time Factors, Tomography, X-Ray Computed, Treatment Outcome, Triazoles adverse effects, Triazoles pharmacokinetics, Young Adult, Active Transport, Cell Nucleus drug effects, Antineoplastic Agents administration & dosage, Hydrazines administration & dosage, Sarcoma drug therapy, Soft Tissue Neoplasms drug therapy, Triazoles administration & dosage
- Abstract
Purpose: We evaluated the pharmacokinetics (PKs), pharmacodynamics, safety, and efficacy of selinexor, an oral selective inhibitor of nuclear export compound, in patients with advanced soft tissue or bone sarcoma with progressive disease., Patients and Methods: Fifty-four patients were treated with oral selinexor twice per week (on days 1 and 3) at one of three doses (30 mg/m(2), 50 mg/m(2), or flat dose of 60 mg) either continuously or on a schedule of 3 weeks on, 1 week off. PK analysis was performed under fasting and fed states (low v high fat content) and using various formulations of selinexor (tablet, capsule, or suspension). Tumor biopsies before and during treatment were evaluated for pharmacodynamic changes., Results: The most commonly reported drug-related adverse events (grade 1 or 2) were nausea, vomiting, anorexia, and fatigue, which were well managed with supportive care. Commonly reported grade 3 or 4 toxicities were fatigue, thrombocytopenia, anemia, lymphopenia, and leukopenia. Selinexor was significantly better tolerated when administered as a flat dose on an intermittent schedule. PK analysis of selinexor revealed a clinically insignificant increase (approximately 15% to 20%) in drug exposure when taken with food. Immunohistochemical analysis of paired tumor biopsies revealed increased nuclear accumulation of tumor suppressor proteins, decreased cell proliferation, increased apoptosis, and stromal deposition. Of the 52 patients evaluable for response, none experienced an objective response by RECIST (version 1.1); however, 17 (33%) showed durable (≥ 4 months) stable disease, including seven (47%) of 15 evaluable patients with dedifferentiated liposarcoma., Conclusion: Selinexor was well tolerated at a 60-mg flat dose on a 3-weeks-on, 1-week-off schedule. There was no clinically meaningful impact of food on PKs. Preliminary evidence of anticancer activity in sarcoma was demonstrated., (© 2016 by American Society of Clinical Oncology.)
- Published
- 2016
- Full Text
- View/download PDF
287. The changing economics of DNA synthesis.
- Author
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Carlson R
- Subjects
- United States, Biotechnology economics, DNA chemical synthesis, DNA economics, Genetic Engineering economics, Genome, Industry economics, Molecular Biology economics
- Published
- 2009
- Full Text
- View/download PDF
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