Search

The purpose of this community service activity is to carry out mental health screening as an effort to detect mental health problems in adolescents early. The method of implementing the activities consists of 3 stages: the preparation stage, the implementation of screening with the SRQ-29 instrument (Self-Reporting Questionnaire 29), and education. One hundred seventy-six teenage students in one of the Padang City State Senior High Schools participated in this activity. Adolescents who participated consisted of grades 10, 11, and 12. The results of these activities found that more than half of adolescents (56.8%) were identified as having symptoms of neurosis (anxiety and depression), more than half of adolescents (63.6%) were identified with psychotic symptoms, most of the adolescents (77.3%) were identified PTSD symptoms, and about 0.6% of adolescents were identified as using psychoactive substances. The results illustrate that most adolescents experience mental health problems in the form of anxiety and depression, psychotic, and PTSD symptoms that require further attention and treatment. For this reason, the attention and active participation of all parties, such as the government (education office, health office, schools) and families, overcome seriously adolescent mental health problems. Improving the function of guidance and counseling services (BK) in schools is very important. Counseling and scheduled mental health education can increase adolescent awareness and understanding of mental health.

The role of parents in determining the lives of their children has been depicted in many media including literary works. This article tries to show how this issue is presented in two novels. Scrutinized from Foucauldian's perspective focusing on power relations between parents and children, this article analyzes Desni Intan Suri's Aku Tidak Membeli Cintamu and Mohja Kafh's The Girl in the Tangerine Scarf. The results show that the parents impose their power in the form of domination. In addition, the authors portray the children's acceptance as well as resistance to domination. Acceptance indicates obedience. On the other hand, resistance is a way to exemplify that parents' dominations can be challenged as children's voices are also valuable.

Abstract This study was conducted to examine times to onset, incidence rates, and outcomes of nivolumab-induced lung adverse events (AEs), using the Japanese Adverse Drug Event Report database. We analysed data for the period between April 2004 and March 2021. Data on lung AEs were extracted, and relative risks of AEs were estimated using the reporting odds ratio. We analysed 5,273,115 reports and found 18,721 reports of nivolumab-related AEs, including 3084 lung AEs. Signals were detected for nine lung AEs: interstitial lung disease; pneumonitis; lung disorder; organising pneumonia; pleural effusion; pneumonia aspiration; pneumonia bacterial; radiation pneumonitis; and infectious pleural effusion. Among these, interstitial lung disease was the most frequently reported (68.7%) and included some fatal cases. A histogram of median times to onset showed AEs occurring from 34 to 79 days after the first dose, but some cases occurred even more than one year after starting administration. In conclusion, we focused on lung AEs caused by nivolumab as post-marketing AEs. Some cases could potentially involve serious outcomes, particularly in interstitial lung disease. Patients should be monitored for signs of the development of these AEs not only at the start of administration, but also over an extended time.

ABSTRACT Aims/Introduction We carried out a cross‐sectional study of people with type 2 diabetes mellitus to elucidate the association between sleep duration and food intake. Materials and Methods Overall, 2,887 participants with type 2 diabetes mellitus (mean age 63.0 years; 61.1% men; mean glycated hemoglobin level 7.5%) were included in this study. The participants' self‐reported dietary habits and sleep duration were evaluated using a brief self‐administered dietary history questionnaire and Pittsburgh Sleep Quality Index, respectively. The participants were categorized into the following four groups based on sleep duration:

Abstrak: Covid-19 telah memberikan dampak perubahan dalam berbagai sektor, salah satunya dalam bidang Pendidikan. Tren pembelajaran berkonsepkan teknologi menjadi perhatian utama selama masa pandemi covid-19. Setiap guru dituntut untuk terampil dan mampu beradaptasi secara cepat dengan kebutuhan teknologi dalam pembelajaran. Masih terbatasnya kemampuan guru dalam mengintegrasikan teknologi seperti salah satunya teramati dalam skema pemberian tugas dan penilaian hasil belajar. Kurangnya pengalaman dan kemampuan dalam mengelola sistem penialaian berbasis digital memberikan peluang untuk dikembangkannya sebuah kelas pelatihan dengan topik penilaian hasil belajar berbasis online (digital assessment). Tujuan dari penelitian ini adalah untuk menghasilkan online course (MOOCs) pada topik pengelolaan penilaian hasil belajar secara online. Jenis Penelitian ini adalah Penelitian dan Pengembangan (R & D), dengan model pengembangan yang dipilih adalah Plomp. Tahapan penelitian sesuai dengan model Plomp meliputi 3 langkah, diantaranya: Preliminary Research, Prototyping Phase (Self evaluation, one to one, expert review, small group dan field test), Assessment Phase. Topik yang dikembangkan pada online course dengan fokus pengelolaan penilaian hasil belajar meliputi: Quizizz, Google Form, Wordwall, EdApp, Quizlet, QuizMaker, Nearpod dan Kahoot. Karena keterbatasan penelitian, ujicoba hanya dilakukan dalam skala kecil. Abstract: Covid-19 has had an impact on changes in various sectors, one of which is in the field of education. The trend of technology-concept learning is a major concern during the COVID-19 pandemic. Every teacher is required to be skilled and able to adapt quickly to technological needs in learning. The limited ability of teachers to integrate technology, one of which is observed in the scheme of assigning assignments and assessing learning outcomes. The lack of experience and ability in managing digital-based assessment systems provides an opportunity for the development of a training class with the topic of online-based learning outcomes assessment (digital assessment). The purpose of this study is to produce online courses (MOOCs) on the topic of managing online learning outcomes assessment. This type of research is Research and Development (R & D), with the development model chosen being Plomp. The research stages according to the Plomp model include 3 steps, including: Preliminary Research, Prototyping Phase (Self evaluation, one to one, expert review, small group and field test), Assessment Phase. Topics developed on online courses with a focus on managing learning outcomes assessment include: Quizizz, Google Form, Wordwall, EdApp, Quizlet, QuizMaker, Nearpod and Kahoot. Due to research limitations, trials are only conducted on a small scale.

Kegiatan ini dilakukan dengan menginduksikan metode Continuously Dynamic Mixing (CDM) yang diterapkan dalam Greenhouse Salt Tunnel (GST) untuk mengkreasi produksi garam di Pantai Selatan Kabupaten Malang. Mitra kegiatan ini adalah Kelompok Usaha Garam Rakyat (Kugar) Bajulmati Sejahtera yang merupakan kelompok usaha garam pertama di Kabupaten Malang. Mitra memiliki masalah terkait dengan teknis produksi garam untuk menghasilkan garam yang berkualitas baik (NaCl > 95%). Indikator keberhasilan kegiatan pengabdian kepada masyarakat ini adalah: 1) teknologi GST di lokasi mitra sudah menggunakan metode CDM untuk produksi garam; 2) peningkatan pengetahuan dan keterampilan mitra dalam pengaturan air dalam metode CDM dalam GST; dan 3) Mitra dapat memproduksi garam berkualitas K-1 dengan peningkatan kapasitas produksi lebih dari 50%. Kegiatan pengabdian kepada masyarakat ini telah dapat mengkreasi produksi garam untuk pertama kali di Pantai Selatan Kabupaten Malang.

Grey water contains organic matter that is directly disposed to the environment without any treatment previously, will cause pollution and impacting life in the water. Treatment that can be done is using microorganisms. One of its kind is the microalgae Chlorella sp. which utilizes organic matter as a source of nutrients for its growth. In this study, the Kaldness 1 (K1) bio carrier was added as a medium for attaching microorganisms using the Sequencing Batch Biofilm Reactor (SBBR) process. The research objectives were (1) to know the maximum number of Chlorella sp. both attached and suspended in the Sequencing Batch Biofilm Reactor (SBBR), (2) to obtain the best cycle time and stabilization time in the removal of COD, Ammonia, and MLSS in grey water. The research was conducted by varying the stabilization time (1.5; 2 and 2.5 hours) in each cycle for four cycles with a constant variation of charging time 30 minutes, reaction 120 minutes, 45 minutes, separation 45 minutes, and carried out with four cycles, stirring speed at 60 rpm, the concentration of algae suspension in SBBR was 25% and the volume of Kaldness K1 medium was 20%. The results showed the number of microalgae cells Chlorella sp. was suspended and attached to 1.85 x 106 and 1.46 x 106 cells/ml. The best removal of COD, ammonia, and MLSS was found in the stabilization time variation of 1.5 hours in 4 cycles with a removal efficiency of 84% and 76%, respectively, and an increase in the concentration of suspended and attached MLSS by 4780 mg/l and 4720 mg/l. It can be concluded that the faster stabilization time, the more removal efficient will be.

Abstract Myxofibrosarcoma (MFS) and undifferentiated sarcoma (US) have been considered as tumors of the same lineage based on genetic/epigenetic profiling. Although MFS shows a notably better prognosis than US, there are no clear criteria for distinguishing between them. Here, we examined 85 patients with MFS/US and found that tumors with infiltrative growth patterns tended to have more myxoid areas and higher local recurrence rates but fewer distant metastases and better overall survival. Morphologically characteristic sickle-shaped blood vessels, which tended to have fewer αSMA-positive cells, were also observed in these tumors, compared with normal vessels. Based on the incidence of these sickle-shaped blood vessels, we subdivided conventionally diagnosed US into two groups. This stratification was significantly correlated with metastasis and prognosis. RNA sequencing of 24 tumors (9 MFS and 15 US tumors) demonstrated that the proteasome, NF-kB, and VEGF pathways were differentially regulated among these tumors. Expression levels of KDR and NFATC4, which encode a transcription factor responsible for the neuritin-insulin receptor angiogenic signaling, were elevated in the sickle-shaped blood vessel-rich US tumors. These findings indicate that further analyses may help elucidate the malignant potential of MFS/US tumors as well as the development of therapeutic strategies for such tumors.

Abstract Background Hypoglycemia in type 1 diabetes (T1D) is associated with mortality and morbidity, especially when awareness of hypoglycemia is impaired. This study aimed to investigate the protective and risk factors for impaired awareness of hypoglycemia (IAH) in adults with T1D. Methods This cross-sectional study enrolled 288 adults with T1D (mean age, 50.4 ± 14.6 years; male, 36.5%; diabetes duration, 17.6 ± 11.2 years; mean HbA1c level, 7.7 ± 0.9%), who were divided into IAH and non-IAH (control) groups. A survey was conducted to assess hypoglycemia awareness using the Clarke questionnaire. Diabetes histories, complications, fear of hypoglycemia, diabetes distress, hypoglycemia problem-solving abilities, and treatment data were collected. Results The prevalence of IAH was 19.1%. Diabetic peripheral neuropathy was associated with an increased risk of IAH (odds ratio [OR] 2.63; 95% confidence interval [CI] 1.13–5.91; P = 0.014), while treatment with continuous subcutaneous insulin infusion and hypoglycemia problem-solving perception scores were associated with a decreased risk of IAH (OR, 0.48; 95% CI, 0.22–0.96; P = 0.030; and OR, 0.54; 95% CI, 0.37–0.78; P = 0.001, respectively). There was no difference in continuous glucose monitoring use between the groups. Conclusion We identified protective factors in addition to risk factors for IAH in adults with T1D. This information may help manage problematic hypoglycemia. Trial registration University hospital Medical Information Network (UMIN) Center: UMIN000039475). Approval date 13 February 2020.

Abstract RAB35 is a multifunctional small GTPase that regulates endocytic recycling, cytoskeletal rearrangement, and cytokinesis. However, its physiological functions in mammalian development remain unclear. Here, we generated Rab35-knockout mice and found that RAB35 is essential for early embryogenesis. Interestingly, brain-specific Rab35-knockout mice displayed severe defects in hippocampal lamination owing to impaired distribution of pyramidal neurons, although defects in cerebral cortex formation were not evident. In addition, Rab35-knockout mice exhibited defects in spatial memory and anxiety-related behaviors. Quantitative proteomics indicated that the loss of RAB35 significantly affected the levels of other RAB proteins associated with endocytic trafficking, as well as some neural cell adhesion molecules, such as contactin-2. Collectively, our findings revealed that RAB35 is required for precise neuronal distribution in the developing hippocampus by regulating the expression of cell adhesion molecules, thereby influencing spatial memory.

Abstract Background Low-grade papillary Schneiderian carcinoma (LGPSC) is a relatively new entity of the sinonasal tract and is characterized by a bland morphology simulating sinonasal papilloma, invasive growth pattern with pushing borders, and aggressive clinical behavior with multiple recurrences and metastatic potential. Recently, DEK::AFF2 fusions were identified in LGPSC. However, some LPGSCs lack DEK::AFF2 fusion, and the molecular features of these tumors have not been clarified. Case presentation A 69-year-old man presented with a discharge of pus from his left cheek. Computed tomography revealed a mass involving the left maxillary sinus, ethmoid sinus, and nasal cavity with the destruction of the orbital wall. The biopsy specimens showed that the tumor had a predominantly exophytic, papillary growth and did not have an apparent stromal invasion. The tumor was composed of multilayered epithelium that showed bland morphology with a round to polygonal shape, abundant eosinophilic cytoplasm, and uniform nuclei. Dense neutrophilic infiltrates were focally present. Immunohistochemically, CK5/6 was strongly and diffusely positive, and p16 was negative. p63 was mainly positive in the basal layer, and EMA was predominantly expressed in the outermost cell layer. DNA-based targeted sequencing showed TP53 R175H mutation, whereas neither EGFR nor KRAS mutation was identified. Reverse transcription polymerase chain reaction and fluorescence in situ hybridization revealed no DEK::AFF2 fusion. Conclusions We describe the first case of TP53-mutant LGPSC and review the literature. LGPSC is a genetically heterogeneous entity, and the recognition of this rare entity and comprehensive assessment of clinicopathological and molecular findings are crucial for the correct pathological diagnosis and clinical management.

Abstract Background Despite vaccination coronavirus disease 2019 (COVID-19)-associated mortality caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains high in kidney transplant recipients. Nirmatrelvir is a protease inhibitor with activity against SARS-CoV-2. Nirmatrelvir reduces the risk for mortality and hospitalization, which is approved for treating adults at risk for severe disease. Nirmatrelvir is metabolized by the cytochrome P-450 (CYP) 3A4 isozyme CYP3A4 and is therefore co-administered with the irreversible CYP3A4 inhibitor ritonavir, which results in a drug interaction with tacrolimus. A limited number of patients with nirmatrelvir/ritonavir and tacrolimus therapy after kidney transplantation have been reported to date. It has been reported that tacrolimus was paused during the five-day nirmatrelvir/ritonavir therapy and subtherapeutic tacrolimus levels were observed after finishing nirmatrelvir/ritonavir in two patients. Therefore, optimization of tacrolimus dosing is urgently needed in transplant recipients receiving nirmatrelvir/ritonavir treatment. Case presentation Here, we present our first-hand experience with four patients receiving tacrolimus therapy following kidney transplantation and nirmatrelvir/ritonavir therapy due to COVID-19. Tacrolimus was paused during nirmatrelvir/ritonavir therapy in all patients, which resulted in stable therapeutic tacrolimus levels. Tacrolimus was continued directly after finishing nirmatrelvir/ritonavir to avoid subtherapeutic levels in the first patient treated. This patient received his usual tacrolimus maintenance dose, which resulted in toxic levels. Based on this observation, tacrolimus therapy was continued 24 h after finishing nirmatrelvir/ritonavir treatment at a reduced dose in the subsequent patients. In these patients, therapeutic to supratherapeutic tacrolimus levels were observed despite the therapeutic break and dose reduction. Discussion and conclusions Based on altered CYP3A4 metabolism, tacrolimus levels have to be closely monitored after treatment with nirmatrelvir/ritonavir. Our study suggests that tacrolimus treatment should be paused during nirmatrelvir/ritonavir medication and be continued 24 h after completing nirmatrelvir/ritonavir therapy at a reduced dose and under close monitoring. Based on the limited number of patients in this study, results must be interpreted with caution.

Indigenous religions encompass spiritual customs originating from the ancestral heritage of specific ethnic and geographical groups. These traditional beliefs often come into conflict with state-recognised official religions, a consequence of modernity's tendency to streamline religion into a mere belief system. In line with this, the post-colonial view sees that indigenous religions which are repressed by the state are the result of the state's view of showing Western superiority. Indonesia bears the enduring legacy of colonialism, manifesting as negative perceptions that persistently affect to indigenous religions. One of the colonial legacies is sociological, psychological, and moral problems, besides physics and material heritance. According to Syeid Hussen Alatas in the Myth of Lazy Natives (1989), this is the greatest damage caused by colonialism because this problem hinders solutions to other problems. Indonesia, as a geographical region, has many indigenous religions, one of which is the Marapu belief in Sumba, East Nusa Tenggara. Many adherents of the Marapu faith are forced to embrace one religion for the purposes of population administration, but at the same time continue to practice their beliefs. This article aims to unravel how Marapu followers uphold their ritual practices within the confines of their traditional religion and how the enduring colonial legacy shaped local religious observances. This study uses a qualitative descriptive method by focusing on a literature review with research data sources from journals and documentary videos. The research finding of this enquiry is the exploration of the intersection between religion and society and how post-colonial perspectives have seen this phenomenon.

Pulmonary arterial hypertension (PAH) remains a significant challenge in cardiology, necessitating advancements in treatment strategies. This study explores the safety and efficacy of transitioning patients from beraprost to selexipag, a novel selective prostacyclin receptor agonist, within a Japanese cohort. Employing a multicenter, open-label, prospective design, 25 PAH patients inadequately managed on beraprost were switched to selexipag. Key inclusion criteria included ongoing beraprost therapy for ≥3 months, a diagnosis of PAH confirmed by mean pulmonary artery pressure (mPAP) ≥ 25 mmHg, and current treatment with endothelin receptor antagonists and/or phosphodiesterase type 5 inhibitors. Outcomes assessed were changes in hemodynamic parameters (mPAP, cardiac index, pulmonary vascular resistance) and the 6 min walk distance (6-MWD) over 3–6 months. The study found no statistically significant changes in these parameters post-switch. However, a subset of patients, defined as responders, demonstrated improvements in all measured hemodynamic parameters, suggesting a potential benefit in carefully selected patients. The transition was generally well-tolerated with no serious adverse events reported. This investigation underscores the importance of personalized treatment strategies in PAH, highlighting that certain patients may benefit from switching to selexipag, particularly those previously on higher doses of beraprost. Further research is needed to elucidate the predictors of positive response to selexipag and optimize treatment regimens for this complex condition.

Excessive consumption of sugary foods increases the likelihood of obesity, as well as the preventable risk of lifestyle illnesses such as diabetes and cardiovascular diseases. Frequent intake of sweet snacks is considered to increase the risk of overweight/obesity in industrial nations. However, we cannot stop snacking against our better judgment. Therefore, in this study, we sought to develop high-protein, low-carb “mock snacks” to satisfy snack lovers’ appetites and nutrition. Soy protein-based, ball-shaped food products with 57.7% (w/w) protein and 3.6% sugar have been developed. The addition of canola oil made them melty in the mouth without sacrificing their crispiness. Moreover, evaluation of the surface topography of the “soy balls” by 3D laser scanning demonstrated their high degree of sphericity. Conclusively, the snacks developed here may be one of the healthy alternatives for the current sugary ones.

Menthyl ester of valine (MV) has been developed as a plant defense potentiator to induce pest resistance in crops. In this study, we attempted to establish MV hydrochloride (MV-HCl) in lettuce and tomato crops. When MV-HCl solutions were used to treat soil or leaves of potted tomato and lettuce plants, 1 µM MV-HCl solution applied to potted plant soil was most effective in increasing the transcript level of defense genes such as pathogenesis-related 1 (PR1). As a result, leaf damage caused by Spodoptera litura and oviposition by Tetranychus urticae were significantly reduced. In addition, MV-HCl-treated plants showed an increased ability to attract Phytoseiulus persimilis, a predatory mite of T. urticae, when they were attacked by T. urticae. Overall, our findings showed that MV-HCl is likely to be effective in promoting not only direct defense by activating defense genes, but also indirect defense mediated by herbivore-induced plant volatiles. Moreover, based on the results of the sustainability of PR1 expression in tomato plants treated with MV-HCl every 3 days, field trials were conducted and showed a 70% reduction in natural leaf damage. Our results suggest a practical approach to promoting organic tomato and lettuce production using this new plant defense potentiator.

Axenfeld-Rieger (AR) syndrome is an inherited Autosomal Dominant (AD) disorder with ocular, dental, and craniofacial defects, whereas AR anomaly presents only with ocular changes. Hereby, the authors present a case report of 40-year-old male patient who reported to the Outpatient Department (OPD) with complaints of diminution of vision in Both Eyes (BE) for three years. There was a significant family history. Visual acuity was limited to hand movements in both eyes. Both eyes showed prominent Schwalbe’s line, iris atrophic patches, and ectropion uvea. Intraocular Pressure (IOP) was high in the Right Eye (RE) and within normal limits in the Left Eye (LE). No craniofacial or dental anomalies were detected. Gonioscopy revealed a closed angle with broad peripheral anterior synechiae in both eyes. Fundus examination revealed a Cup Disc Ratio (CDR) of 0.5 in the RE and 0.9 in the LE. AR anomaly is a rare case. Long-term follow-up of these cases is as important as early diagnosis and treatment to prevent blindness.

The present study sheds light on epistemic stance of discourse markers nih on the assessment conducted on YouTube food reviews spoken in colloquial Jakartan Indonesian. Nih indicates speakers’ claim of sharing knowledge. The speakers position themselves as the ones who have knowledge and share it with the watchers who are assumed as the ones with no knowledge of the objects. Mostly, nih is used in the first assessment. In the second assessment, the speakers tend to illustrate the unclear aspect of the first assessment by applying nih. The speakers also apply simile when assessing the dishes to associate the items assessed with more common items. Thus, it will be easier for the audience to comprehend every detail of the assessment. Nih tends to collocate with demonstratives nih, ni, and ini. With the collocations, the speakers guide the hearers to notice the objects or the actions before distributing the knowledge.

Excessive internet use in adolescents can lead to addiction, with parental parenting styles playing a pivotal role. This study aimed to analyze the relationship between parents' parenting style and adolescent internet addiction. A cross-sectional study was conducted with a sample of 290 participants using convenience sampling. Two instruments, the Parental Authority Questionnaire (PAQ) and Internet Addiction Test (IAT), were employed for data collection. Statistical analysis, using the Spearman correlation test (p < 0.05), was performed. Findings revealed a significant relationship (p < 0.001, r = 0.253) between an authoritarian paternal parenting style and adolescent internet addiction. A permissive maternal parenting style also exhibited a significant link (p < 0.001, r = 0.319) with internet addiction. This study highlights a clear association between parenting styles and adolescent internet addiction. Parents should balance granting freedom for responsible internet use with setting boundaries, engage in open dialogues, and issue warnings when excessive online time is detected to effectively address this issue.

Despite the conclusion of the pandemic, addressing mental health concerns during disasters remains crucial. Examining the impact of mental health issues in such contexts yields valuable insights for preventing future crises. This study aimed to examine the factors linked to anxiety and depression symptoms among Indonesian adolescents during the COVID-19 pandemic. This was a cross-sectional study. The study utilized an online survey collected from 738 participants from 34 provinces in Indonesia. The participants were asked to provide information on their demographics, social media exposure, self-rated health, GAD-7 scores, and the WHO-5 well-being index. The associations between participant characteristics and depression and anxiety were investigated using independent t-tests, ANOVA tests, and ordinal logistic regression. The majority of the participants were late adolescents, aged 18-21 years old (95%), and female (79.1%). Factors such as gender, self-rated health, and social media exposure were significantly associated with depression and anxiety among adolescents during the COVID-19 pandemic. Male adolescents had a higher risk of depression (OR=0.657, 95% CI=0.476-0.908), while infrequent social media exposure was linked to lower anxiety levels (OR=0.401, 95% CI=0.190-0.847). The study revealed that younger age, female sex, suspected COVID-19 infection, and excessive social media exposure were associated with higher levels of depression and anxiety. To manage depression and anxiety during and after pandemics, it is crucial to provide valid and reliable information and healthcare services, foster social connections, and create supportive environments in households and workplaces.

Abstract. The Indonesian construction sector plays a substantial role in the nation's economic growth. According to the World Economic Forum, this industry currently contributes approximately 6% to the global GDP and is projected to increase to 14.7% by 2030. Nevertheless, the construction sector predominantly relies on traditional craft-based methods, resulting in suboptimal performance and quality due to limited technology utilization. Hence, the Indonesian construction industry must increase investment in technology adoption, development, and application to enhance national development support. Material technology plays an essential role in construction projects. A survey of 40 Indonesian contractors revealed that the utilization priority for concrete and steel materials remains high under normal conditions and during the covid-19 pandemic. This study aims to provide a comprehensive overview of the historical development, utilization, contribution, and future strategy for concrete and steel construction material technology in Indonesia. Contrastingly, this data is crucial for shaping construction technology development and utilization policies in Indonesia. The study will systematically chart the technological landscape in the country, employing literature reviews, interviews, and questionnaires as its methodology. Abstrak. Sektor konstruksi Indonesia memainkan peran penting dalam pertumbuhan ekonomi negara ini. Menurut World Economic Forum, industri ini memberikan kontribusi sekitar 6% terhadap Produk Domestik Bruto (PDB) global dan diperkirakan akan meningkat menjadi sekitar 14,7% pada tahun 2030. Namun, sektor konstruksi masih sangat mengandalkan metode tradisional, yang mengakibatkan kinerja yang kurang optimal dan kualitas yang rendah karena rendahnya penggunaan teknologi. Oleh karena itu, industri konstruksi Indonesia harus meningkatkan investasi dalam adopsi, pengembangan, dan penerapan teknologi untuk meningkatkan dukungan pengembangan nasional. Teknologi material memainkan peran penting dalam proyek konstruksi. Sebuah survei terhadap 40 kontraktor Indonesia mengungkapkan bahwa prioritas pemanfaatan material beton dan baja tetap tinggi dalam kondisi normal dan selama pandemi covid-19. Studi ini bertujuan untuk memberikan gambaran menyeluruh tentang perkembangan historis, pemanfaatan, kontribusi, dan strategi masa depan untuk teknologi material konstruksi beton dan baja di Indonesia. Sebaliknya, data ini krusial dalam kebijakan pengembangan dan pemanfaatan teknologi konstruksi di Indonesia. Studi ini akan secara sistematis menggambarkan lanskap teknologi di negara ini, dengan menggunakan studi literatur, wawancara, dan kuesioner sebagai metodologi utamanya.

Abstract Background Trousseau syndrome is a hypercoagulability syndrome associated with cancer. It is known that delirium occasionally occurs after the onset of Trousseau syndrome. However, there have been no detailed reports about treatment for psychiatric symptoms of delirium associated with Trousseau syndrome. Case Presentation A 61‐year‐old man with lung cancer was hospitalized due to Trousseau syndrome. Delirium occurred after hospitalization and psychiatric symptoms worsened. Although haloperidol, risperidone, and chlorpromazine were used, severe insomnia persisted. After memantine (5 mg/day) was used with perospirone, the patient's psychiatric symptoms gradually decreased; he could sleep for 4–5 h at night. Due to psychiatric improvement, he was able to return home and resume immunotherapy for lung cancer as scheduled. Conclusion We report the first case of Trousseau syndrome delirium treated by memantine used with perospirone. Although further studies are needed, memantine and perospirone might be candidates for the management of psychiatric symptoms associated with Trousseau syndrome.

X-ray Microcomputed Tomography (µCT) is rapidly becoming an important analytical technique for examining the precise morphometry of small objects. The most notable feature of this technique is that it enables nondestructive, highly accurate morphometric measurements at micrometer-order resolution. In the Earth sciences, this makes µCT extremely useful for clarifying how genetic associations and the surrounding environment affect the morphology of micro-sized organisms. However, the actual analytical methods and the points that must be considered to produce reliable data have rarely been discussed in detail. Here, to address this lack of discussion, we describe in detail our methodology for precise µCT-based morphometry by using a test of the planktonic foraminifer and marine calcifier Globorotalia inflata. In addition to demonstrating the long-term stability of our µCT setup and analytical approach, we also propose a new methodology for test bulk density calibration using artificial carbonate phantoms. We expect that µCT together with our artificial phantom-based methodology will be useful for calculating accurate test bulk densities of micro-sized marine calcifiers.

Background: Self-care behavior is crucial in preventing chronic diseases, such as hypertension, which has become highly prevalent in Indonesia. Hypertension, often referred to as the “silent killer” due to its asymptomatic nature, can easily go unnoticed. Neglecting its treatment can lead to severe complications, including heart disease, heart failure, and stroke. Despite adults with hypertension feeling well, embracing self-care behavior, including making healthy lifestyle choices, disease management, and enhancing life quality, remains essential. Objective: This study aimed to describe the self-care behavior of adult patients with hypertension in Indonesia. Methods: A cross-sectional study design was employed, involving 270 participants selected through consecutive sampling. Data were collected between 15 March and 4 April 2023, using the Hypertension Blood Pressure Self Care Profile (HBP-SCP) questionnaire in six public healthcare centers in Padang City, West Sumatra, Indonesia. The data were analyzed using descriptive analysis, Mann-Whitney, and Kruskal-Wallis tests. Results: The self-care behavior among adult patients with hypertension was at a moderate level (Mean = 49.78, SD = 6.64), and it had significant differences according to ethnicity (p = 0.041), marital status (p = 0.017), and body mass index (p = 0.008). Conclusion: The findings highlight the influence of diverse ethnic backgrounds, various marital statuses, and differing body mass index levels, which may lead to distinct approaches to managing hypertension. These results offer valuable insights for nurses and other healthcare professionals to develop comprehensive strategies to enhance self-care among adult patients with hypertension.

The aim of this article is to investigate isolation experiences of individuals affected by Covid-19 and explore how care practices were enacted or upheld under the particular policies of the pandemic. Conceptually we draw upon Foucault's notion of biopolitics and scholarship on ‘care practices’ and ‘carescapes’. We are interested in how theoretical ideas such as ‘containing the virus’ or ‘flattening the curve,’ as part of policies of ‘pandemic management,’ shaped lived realities and influenced practices and understandings of care. We reviewed qualitative interviews with individuals who were ill with Covid-19 in 2020/2021 from seven countries that we analyzed comparatively across emerging themes with a Foucauldian lens on biopolitics.The idea of ‘carescapes,’ suggests that ‘care’ and ‘policy’ intermingle, which allow us to bring to the fore what is silenced through the biopolitics of Covid-19. Carescapes are the embodied places of care where policies and regulations traverse from public into private spaces, effectively re-configuring the latter. To ‘do’ isolation in the context of Covid-19, carescapes were assembled with the help of material things such as, masks, disinfectants, doors and schedules; these served as boundaries that had to be sustained and navigated. ‘Doing isolation’ therefore presents a form of biopolitics that relies on individual citizenship and complex care practices required to chart the terrain created by the polices of the pandemic. Doing isolation was especially challenging because policies about safe spaces and safe practices were regularly changed as governments struggled to devise policies to contain the pandemic.

BackgroundIt is established that a low body mass index (BMI) correlates with a diminished home discharge rate and a decline in activities of daily living (ADL) capacity among elderly stroke patients. Nevertheless, there exists a paucity of knowledge regarding strategies to mitigate BMI reduction during the acute phase. This investigation seeks to elucidate the impact of rehabilitation dose, as determined by both physical and occupational therapy, on BMI alterations, positing that a heightened rehabilitation dose could thwart BMI decline.MethodsThis retrospective, observational study was conducted in the stroke unit of a university hospital. Enrollees comprised individuals aged ≥65 years, hospitalized for stroke, and subsequently relocated to rehabilitation facilities between January 2019 and November 2020. The percentage change in BMI (%ΔBMI) was calculated based on BMI values at admission and discharge. Multivariate multiple regression analysis was employed to ascertain the influence of rehabilitation dose on %ΔBMI.ResultsA total of 187 patients were included in the analysis, of whom 94% experienced a reduction in BMI during acute hospitalization. Following adjustment for sociodemographic and clinical factors, multivariable analyzes revealed a positive association between rehabilitation dose and %ΔBMI (β = 0.338, p

Isatin (1H-indole-2,3‑dione) is a natural heterocyclic compound extracted from various plants and has biological activity as an anticancer agent. Chalcones with the addition of several functional groups (hydroxyl, carboxyl, phenyl, etc.) may become useful templates for the development of new anticancer agents. In this study, we have synthesized Cu/NiO nanoparticles using the sol-gel method involving annona muricata L leaf extract and used as catalysts for the synthesis of isatin-based chalcone. These compounds will be applied as anticancer agents against MCF-7 cancer cell. According to the characterization results using FT-IR, XRD, FESEM-EDS, the crystal size for Cu/NiO nanoparticles was 5.4566 nm and the particle size was 25.081 ± 8.422 nm with irregular spherical shapes. The synthesis of isatin based on chalcone using the reflux method refers to the claisen schmidt condensation reaction using 5% mmol Cu/NiO nanoparticles resulting in yields for each product of 50 % (product 1), 32.37 % (product 2), 24.29 % (product 3), 32.35 % (product 4), 50.86 % (product 5), and 69.88 % (product 6). The effectiveness of the six products against MCF-7 cancer cells can be seen from the IC50 values as follows product 1 (IC50 = 0.00157 µg/ml), product 2 (IC50 = 100.897 µg/ml), product 3 (IC50 = 81.991 µg/ml), product 4 (IC50 = 8107.54 µg/ml), product 5 (IC50 = 77.9291 µg/ml), product 6 (IC50 = 25.4521 µg/ml). Based on the IC50 value obtained, it shows that product 1 and product 6 have strong activity when compared to another product on against MCF-7 cancer cells. • Acetophenone as a simple ketone was modified to 2-acetylpyridine. • Modification was performed adding Cu/NiO nanoparticle as catalyst. • Final products exhibited anticancer activity (MCF-7).

AbstractThis study examines the influence of perceived organizational support on middle manager perceptions by demonstrating that the organization values their well-being, causing them to contribute to organizational growth. This study also tries to explain how psychological capital mediates the impact of perceived organizational support on organizational citizenship behavior among middle managers at the Indonesian Nusakambangan correctional institution. Data is collected from 76 middle managers and analyzed using Partial Least Square—Structural Equation Modeling. The test results indicate a significant influence between perceived organizational support on organizational citizenship behavior and psychological capital and psychological capital on organizational citizenship behavior. The test results also show that psychological capital can mediate perceived organizational support for organizational citizenship behavior. Correctional institutions should be prepared for a variety of situations that are prone to security disruptions. The middle managers and all other team members must be confident that all work activities will go according to plan. This study implies that belief or trust may develop effectively when an organization recognizes employees’ contributions to long-term difficulties to achieve all necessary alternative answers. The study highlights the importance of psychological capital as a direct effect or mediator that drives middle managers towards positive and better mental health, specifically in a volatile organization like a correctional institution.

The public perception of government approaches to pandemic management has played an important role in citizen responses to the COVID-19 pandemic. Although the state and associated health institutions should feasibly be sources of epistemic authority, the pandemic has undermined their legitimacy as anti-science rhetoric proliferated and ‘fake news’ spread rapidly. In this paper, we present a comparative analysis of interviews with citizens across four different countries and explore how a lack of consistency and clarity in public health guidance from government and other trusted institutions led to a polarisation in public perceptions and mixed understandings of the pandemic. Using interview data collected across Brazil, Japan, Spain and the United Kingdom, we explored whether there were differences in the extent to which both state governments and scientific institutions were perceived as epistemic authorities through managing the pandemic. Participants grappled with a distrust of government guidelines, finding alternative sources of information to manage perceived infection risk, and make decisions around self-medication. Our analysis suggests several components were key to maintaining trust – and therefore epistemic authority – during the pandemic: reliability of the information delivered by different government bodies, including clarity of messaging; reliability of the government bodies themselves, including whether officials conducted themselves appropriately; and honesty about claims to expertise, including communicating when the scientific evidence was unclear or inconclusive. Our data suggests that honest communication about the limits of their knowledge would assist governments in engendering trust among citizens, and theoretically, compliance with public health guidelines.

This paper addresses working people's narrated experiences of managing covid-related sickness in relation to employment. Bringing together the sociology of chronic illness and disability, and of work and organisations, we contribute to understandings of Covid-19 experiences in the context of employment. We draw from interview studies of Covid-19 infection and recovery in four countries, the UK, the USA, Australia and Japan. This cross-country comparative qualitative approach enables us to suggest how macrostructural regulatory and policy environments, and micropolitical environments of social interaction and moral evaluation shape paths between disclosure to employers, sick leave-taking, recovery and return to work after Covid-19 infection. For many of our participants across the four countries – especially those lacking in job security – this path was not straightforward, entailing intertwined moral and material risks. We draw out wider real-world implications, with regards to precarious work and limited governmental safety nets, and sociological implications in terms of un-flattening our analyses of how people encounter and dispose of trouble at work.

This paper aims to further understanding of discourses of responsible bio-political citizenship during the first year of the Covid-19 pandemic. This was an interview-based qualitative study comparing experiences of 103 people who were ill with Covid for the first time across 2020 in Japan, Germany, the USA and the UK. Comparative thematic analysis explored discussion of responsibility in relation to Covid illness, experiences of social fracture and stigma, and the strategies employed to resist or mitigate stigma. This comparative analysis highlighted significant similarities across countries. We identified three mysteries of Covid illness experiences that impacted the work of navigating biopolitical citizenship. First, the mystery of how people caught Covid. There was an inherent paradox of following guidance yet nonetheless falling ill. Disclosure of Covid to minimise further transmission was held in tension with accusations of irresponsibility. Second, the mystery of onward transmission. Uncertainty about transmission placed participants in a liminal space of potentially having caused harm to others. Third, the mystery of how long illness should last. Uncertainty about ongoing infectiousness made social re-entry difficult, particularly in instances of persistent symptoms. We demonstrate the instability of certainty in the context of new and emerging forms of biopolitical citizenship. Guidance and emerging scientific evidence sought to demystify Covid through providing certainty that could guide responsible actions, but where citizens experienced paradoxes this had the potential to exacerbate stigma.

ABSTRACT Sustainability-focused research networks and communities of practice have emerged as a key response and strategy to build capacity and knowledge to support transformation towards more sustainable, just and equitable futures. This paper synthesises insights from the development of a community of practice on social-ecological systems (SES) research in southern Africa over the past decade, linked to the international Programme on Ecosystem Change and Society (PECS). This community consists of a network of researchers who carry out place-based SES research in the southern African region. They interact through various cross-cutting working groups and also host a variety of public colloquia and student and practitioner training events. Known as the Southern African Program on Ecosystem Change and Society (SAPECS), its core objectives are to: (1) derive new approaches and empirical insights on SES dynamics in the southern African context; (2) have a tangible impact by mainstreaming knowledge into policy and practice; and (3) grow the community of practice engaged in SES research and governance, including researchers, students and practitioners. This paper reflects on experiences in building the SAPECS community, with the aim of supporting the development of similar networks elsewhere in the world, particularly in the Global South.

Keberadaan lahan Demplot Kelompok Wanita Tani (KWT) “PARAWEI” di Kelurahan Marang yang sudah lama tidak digunakan bahkan kondisinya sudah sangat tidak terawat menjadi alasan peneliti untuk menjadikan lahan tersebut sebagai lahan TOGA. Selain itu, belum adanya lahan TOGA bagi masyarakat di kelurahan Marang juga menjadi alasan adanya revitalisasi lahan TOGA dengan tujuan agar lahan tersebut dapat dimanfaatkan oleh masyarakat setempat sebagai tempat menanam tanaman atau mengambil tanaman obat yang diperlukan baik untuk keperluan bumbu masakan maupun kesehatan. Tanaman obat yang di tanam dilahan TOGA salah satunya adalah jahe. Jika biasanya tanaman jahe ini dimanfaatkan menjadi jamu cair yang hanya mampu bertahan sekitar 2-3 harian saja, maka perlu diadakannya pemanfaatan tanaman jahe ini agar mampu bertahan lebih lama sehingga dilakukanlah workshop mengenai “Bubuk Jahe Instan”. Tujuan dari diadakannya workshop ini yaitu agar masyarakat dapat mengolah tanaman jahe menjadi bubuk jahe instan yang lebih praktis dan dapat bertahan lebih lama dibandingkan jamu cair. Adapun dalam pelaksanaan kedua kegiatan ini telah melalui serangkaian metode diantaranya wawancara, observasi dan dokumentasi.

Background: Emotional and Behavioral Problems (EBPs) are prevalent among adolescents, and adolescents’ capacity for adaptation can be influenced by their interactions with their parents, environment, and self-esteem. This link has not been systematically examined among adolescents in West Sumatra, Indonesia. This study aimed to assess the association of parental attachment and self-esteem with EBPs in adolescents. Methods: A cross-sectional study was conducted from July to November 2022 in Padang West Sumatra, Indonesia. In total, 854 students from public senior high school 4 Padang were involved in this study and completed questionnaires on demographics, EBPs, parental attachment, and self-esteem. There was a total of five subscales for EBPs, which included emotional problems, conduct problems, hyperactivity, peer problems and prosocial. Additionally, there were three subscales for parental attachment, which included the mother's attachment, father's attachment, and peer attachment. Spearman's correlation, independent-sample t-tests, ANOVA and multiple linear regression analysis were employed to examine factors associated with EBPs. Results: This study showed that father's attachment (r = −0.191, p

Road damage in the UB Forest Sumberwangi Area, Karangploso District, Malang Regency, is one of the harmful impacts of the drainage system. This study aims to analyze an accurate and efficient drainage system by applying modern methods, namely Building Information Modeling (BIM). By using BIM, the analysis of drainage work becomes faster and more accessible than with conventional methods. BIM is beneficial in building and analyzing drainage network data quickly and effectively and can help expand it to provide more accurate results. BIM can integrate models based on technical data and simulate development information into a three-dimensional model. BIM is used to perform 3D modeling of drainage channels using Autodesk Civil 3D, as well as analyzing channels from both hydrology and hydraulics with Storm and Sanitary Analysis (SSA). After calculating the design for a 5-year return period rainfall, channel dimensions of 50 x 50 cm and 30 x 30 cm were obtained. Based on the hydraulic analysis, it is known that several points have velocities that exceed the maximum velocity for the concrete surface (v < 3 m/s), so it is necessary to build a drop structure with h = 1 m. The quantity take off and the volume are calculated by Civil 3D for cut and fill work 7824.07 m3 and 1389.79 m3, respectively.

Penelitian ini adalah penelitian pengembangan yang berfokus pada pengkajian konten Virtual Laboratory berbasis Augmented Reality (Vilbar) untuk mendukung pelaksanaan praktikum. Metode pengembangan yang digunakan adalah model ADDIE yang terdiri dari lima tahapan: analisis, desain, pengembangan, implementasi, dan evaluasi. Berdasarkan hasil penelitian yang telah dilakukan, terlihat bahwa hasil validator menunjukkan bahwa nilai validasinya yakni 3,85 interval (3,5 < X < 4) ini menandakan bahwa keseluruhan perangkat yang divalidasi berada pada kategori “sangat valid”. Vilbar yang dikembangkan ini dapat memudahkan proses pelaksanaan prakikum sehingga dapat dikatakan memiliki nilai kepraktisan dengan total nilai kepraktisan yang diperoleh 3,6, dan dapat meningkatkan keterampilan pratikum mahasiswa sehingga dapat dikatakan memiliki nilai keefektifan yang dapat dilihat dari hasil portofolio (laporan ) belajar mahasiswa diperoleh nilai rata-rata portofolio hasil praktikum mahasiswa sangat tinggi yaitu sebesar 90. Vilbar telah terbukti efektif dalam mengatasi tantangan dalam praktikum kimia di Universitas Muslim Maros, termasuk keterbatasan ruang, alat, dan bahan praktikum. Vilbar tidak hanya memungkinkan simulasi praktikum kimia yang realistis, tetapi juga meningkatkan antusiasme dan keterampilan praktikum mahasiswa. Penelitian ini menunjukkan bahwa integrasi teknologi dalam pendidikan, seperti penggunaan Vilbar, dapat meningkatkan kualitas pembelajaran dan membantu mahasiswa memahami materi dengan lebih baik. Kesimpulannya, Vilbar merupakan inovasi penting dalam pendidikan kimia yang mendukung pembelajaran interaktif dan mandiri, serta mempersiapkan mahasiswa untuk menghadapi dunia kerja secara profesional dengan keterampilan yang relevan.

Bioethanol is an organic compound resulted from the fermentation of sugar substrates by microorganisms which is used as alternative energy sources. During bioethanol fermentation yeast are exposed to various fermentation stresses, including temperature, osmotic, and oxidative stresess. Such conditions may decrease ethanol production. We previously isolated fermentation-stress tolerance yeast isolates from traditional Balinese beverages, identified as Wickerhamomyces anomalus BT2, BT5, and BT6. However no data available regarding the bioethanol production of those isolates. Our study indicates that these strains could utilize various sugar substrates (glucose, xylose, maltose, sucrose) in oxidative fermentative media. The highest value of substrate utilization efficiency following 48 hours fermentation was shown by BT6 on glucose (61.02%), BT 2 on xylose (55.44%) and maltose (60.90%). Measurement of ethanol production by Gas Chromatography showed that the strains were able to produce higher ethanol on the glucose substrate than other substrates. For instance, BT6 could produce the highest ethanol production (5.00 g/L) amongst strains tested by using glucose as substrate. Yet, the particular strains could only produce 0.30 g/L and 0.65 g/L by using xylose and maltose, respectively. For further genetic engineering purposes, we detected ADH1 gene from all three isolates, with high homology to the alcohol dehydrogenase from Saccharomyces cerevisiae, Geobacillus stearothermophilus and Pseudomonas aeruginosa. Further strain development can be carried out targeting the ADH1 gene, important for ethanol fermentation.

Abstract Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome‐wide association studies (GWAS) integrated with single‐cell expression quantitative trait loci analyses (eQTL) can pinpoint cell‐type specific candidate disease‐relevant genes and pathways. This knowledge can be applied to patient stratification and novel therapeutic target identification. Here, we describe the translational potential of cell‐type specific genetic regulation, using Crohn's disease as an example.

Favipiravir merupakan antivirus untuk pengobatan COVID-19 karena mekanisme kerja obat atau efektivitasnya yang baik pada pasien COVID-19 dengan atau tanpa pneumonia. Penelitian ini observasional, pengambilan data secara retrospektif dan dianalisis secara deskriptif. Bahan penelitian adalah data rekam medis pasien COVID-19 pneumonia yang menggunakan favipiravir periode Desember 2020-Mei 2021. Sebanyak 33 sampel yang diperoleh memenuhi kriteria inklusi dan eksklusi. Efektivitas dianalisis dengan menghitung persentase pasien COVID-19 pneumonia yang hanya menggunakan favipiravir selama dirawat hingga pasien dipulangkan. Efek samping diukur menggunakan parameter kejadian peningkatan AST, ALT, dan penurunan neutrofil. Hasil penelitian menemukan favipiravir efektif pada pasien COVID-19 pneumonia dilihat dari 78,79% pasien yang hanya menggunakan favipiravir saja selama dirawat. Terdapat 7 pasien (26,92%) mengalami neutropenia, dan tidak terdapat pasien yang mengalami peningkatan AST dan ALT >3´ nilai batas atas normal.

Foxtail millet (Setaria italica L. Beauv.) is a grain-producing crop with high nutritional benefits and adaptability to broad environmental conditions. Indonesian local foxtail millet accessions are valuable genetic resources for crop improvement of the species. This study aims to assess the biodiversity of Indonesian local foxtail millet accessions and estimate their salinity tolerance level utilizing the SiDREB2-based SNAP marker and early evaluation at the seedling stage. Our results showed that eight Indonesian local foxtail millet accessions, namely Toraja, Mauliru-2, Hambapraing, NTB-1, ICERI-5, ICERI-6, Botok-4, and Botok-10, had high variability based on agro-morphological traits. The Hambapraing and Mauliru-2 were the potential accessions with high yield estimates (2.33 ton.ha-1 and 1.93 ton.ha-1) and early harvest time (

BackgroundThis study describes the program and learning outcomes of a telehealth skills curriculum based on the Association of American Medical Colleges (AAMC) telehealth competencies for clerkship-level medical students.MethodsA total of 133 third- and fourth-year medical students in a required family medicine clerkship at Stanford University School of Medicine participated in a telehealth curriculum, including a telehealth workshop, site-specific telehealth clinical encounters, and telemedicine objective structured clinical examinations (teleOSCEs) between July 2020 and August 2021. Their workshop communication and physical examination competencies were assessed in two teleOSCEs utilizing a novel telehealth assessment tool. Students' attitudes, skills, and self-efficacy were assessed through voluntary pre-clerkship, post-workshop, and post-OSCE surveys.DiscussionMost learners reported low confidence in their telehealth physical examinations [n = 79, mean = 1.6 (scale 0–5, 5 = very confident, SD = 1.0)], which improved post-workshop [n = 69, 3.3 (0.9), p < 0.001]; almost all (97%, 70/72) felt the workshop prepared them to see patients in the clinic. In formative OSCEs, learners demonstrated appropriate “webside manner” (communication scores 94–99%, four items) but did not confirm confidentiality (21%) or review limitations of the visit (35%). In a low back pain OSCE, most learners assessed pain location (90%) and range of motion (87%); nearly half (48%) omitted strength testing.ConclusionOur telehealth curriculum demonstrated that telehealth competencies can be taught and assessed in medical student education. Improvement in self-efficacy scores suggests that an 80-min workshop can prepare students to see patients in the clinical setting. Assessment of OSCE data informs opportunities for growth for further development in the curriculum, including addressing visit limitations and confidentiality in telehealth visits.

Faktor genetik memegang peran pen ting penyebab terjadinya kanker payudara. Terutama pada anak dari ibu yang terkena kanker payudara memiliki kesempatan 2 kali lebih besar terkena kanker payudara. masih sedikit penelitian yang menggunakan metode kualitatif sejauh ini menggali gambaran pengalaman anak dari ibu yang terdiagnosa kanker dalam kewaspadaan dan pencegahan kanker. Penelitian ini merupakan penelitian kualitatif dengan menggunakan metode pendekatan fenomenologi. Data diambil dari wawawancara mendalam 10 anggota keluarga pasien kanker paliatif. Setelah data di analisis ,diekstraksi maka diklasifikasikan ke dalam 3 tema sebagai berikut: 1) Kurangnya pengetahuan dan kemampuan yang terbatas dalam melakukan sadari 2) Keengganan dalam mengetahui kanker Payudara, 3) Harapan keluarga terhadap dukungan dari dokter dan perawatan di rumah yang mendukung perawatan anggota keluarganya,. Penelitian ini menegaskan pentingnya pentingnya seorang anak mendapatkan konseling dan edukasi kesehatan tentang kewaspadaan kanker dengan berkaca pada ibunya yang terdiagnosa kanker payudara.

The COVID-19 pandemic had an impact on people living with heart disease. They often delay in control time to visit the health care unit, cancelling treatment or not continuing their medication. This condition results in decreasing health status, increasing re-current events, rehospitalization, and low quality of life. Implementation of self-management was essential in managing their disease during daily care at home. Efforts to increase the knowledge of self-management among people living with heart disease were a preventive measure to maintain their health status. These activities aimed to improve self-management knowledge among people living with heart disease in daily care. The method used group education among 22 people in the Bansa district. We used the self-management questionnaire's knowledge to measure knowledge through a pre and post-test. Data analysis was presented in descriptive statistics. The result showed an increased knowledge of self-management; the complete knowledge of self-management before education was 31.86, and after education was 43.00. Education effectively improved the knowledge of communities about self-management behaviour that can be implemented in their daily life. Continuing education is important as a preventive and persuasive strategy to increase the health status of communities.

Abstrak. Penelitian ini bertujuan untuk melihat perbedaan kemampuan pemahaman konsep matematis serta self confidence siswa yang mendapatkan pembelajaran Model Eliciting Activities dengan siswa yang mendapatkan model pembelajaran secara langsung pada materi Bangun datar segitiga di kelas VII. Penelitian ini menggunakan desain Quasi Eksperimental dengan rancangan the nonequivalent posstest-only control group design. Populasi dalam penelitian ini adalah semua kelas VII SMP Negeri 2 Singkawang yang terdiri dari lima kelas. Sampel diambil dengan teknik Cluster Random Sampling. Adapun sampel yang dipilih terdiri dari dua kelas yaitu kelas VIIB sebagai kelas eksperimen dan kelas VIIC sebagai kelas kontrol. Hasil penelitian menunjukkan: 1) Terdapat perbedaan kemampuan pemahaman konsep matematis terhadap siswa yang mendapatkan pembelajaran Model Eliciting Activities dengan siswa yang mendapatkan model pembelajaran langsung pada materi segitiga kelas VII SMP Negeri 2 Singkawang. Hal ini dibuktikan dengan uji Mann Whitney U-Test. Hal ini dibuktikan dengan uji Mann Whitney U-Test; dan 2) Self Confidence siswa tergolong tinggi terhadap pembelajaran Model Eliciting Activies. Hal ini dibuktikan dengan rata-rata self confidence siswa berada pada kriteria sangat tinggi. Kata Kunci: MEAs, Pemahaman Konsep, SC siswa.

Latar Belakang: Kekerasan merupakan salah satu penyebab kematian terbesar di dunia. Kekerasan dapat dibuktikan dengan menemukan tanda-tanda kekerasan pada jenazah yang tergambarkan dari jenis luka yang ditemukan. Jenis kekerasan dapat berupa kekerasan mekanik, fisika, maupun kimia. Berbagai data terkait usia, jenis kelamin, sampai pendapatan negara juga berhubungan dengan kejadian luka dan kekerasan. Objektif: Untuk mengetahui gambaran perlukaan jenazah di Bagian Forensik RSUP Dr. M. Djamil Padang Periode 2019– 2021. Metode: Penelitian ini menggunakan desain deskriptif retrospektif. Pengambilan sampel menggunakan teknik total sampling. Sampel berupa Visum et Repertum jenazah dengan perlukaan yang tercatat di Bagian Forensik RSUP M.Djamil Padang periode 2019– 2021. Analisis data secara univariat. Hasil: Hasil penelitian pada 77 VeR jenazah dengan perlukaan mendapatkan total luka sebanyak 1.463 buah dan jenis kekerasan sebanyak 83 buah. Kelompok usia terbanyak yaitu kelompok usia 30–59 tahun (42,9%), jenis kelamin terbanyak adalah laki-laki (77,9%), agama terbanyak adalah islam (96,1%), jenazah paling banyak merupakan golongan pelajar (19,5%), alamat terbanyak berasal dari Kota Padang (28,6%) dengan jenis kedatangan terbanyak merupakan rujukan dari fasilitas kesehatan lain (71,4%). Jenis luka terbanyak adalah luka lecet (58,2%), luka memar (19,2%), dan luka terbuka tepi tidak rata (11,6%). Jenis kekerasan terbanyak adalah kekerasan tumpul (92,8%). Kesimpulan: Jenazah dengan perlukaan terbanyak berada pada kelompok usia 30–59 tahun, lebih banyak laki-laki daripada perempuan, mayoritas jenazah menganut agama Islam, paling banyak merupakan golongan pelajar, dan alamat terbanyak berasal dari Kota Padang dengan jenis kedatangan paling banyak adalah rujukan dari fasilitas kesehatan lain. Jenis luka terbanyak adalah luka lecet, diikuti luka memar, dan luka terbuka tepi tidak rata dengan penyebab luka terbanyak adalah kekerasan tumpul.

This study aims to develop an e-module based on Contextual Teaching and Learning (CTL) as a physics learning media and to test its feasibility. The study employed a research and development method (R & D). This research produces a digital learning media for the Physic topic of reflection of light and refraction of light, which can assist students in studying independently by following the syntax of CTL. The e-module combines video, audio, and interactive quiz features. The development process was conducted through the ADDIE model where the researcher evaluate every step in the development process. The e-module was developed according to the syntax of CTL. Validation of the e-module was conducted during the development steps. The validation results by the material expert gained a score of 85.09%, while the media expert gained a score of 82.14%. The e-module was implemented in a small group of nine students and gained a score of 84.71%. These scores mean that the e-module was considered feasible and very good.

Abstract VHH, the antigen-binding fragment of a heavy chain-only antibody, is a useful component of antibody-based therapeutics. Thermal stability, represented by the melting temperature (Tm), is one of the key factors affecting the developability of antibody-based therapeutics. In this study, we examined whether the in silico free energy score dStability can be used to design mutants with improved Tm compared to the anti-lysozyme VHH, D3-L11. After verifying that exhaustive mutagenesis was inefficient for improving Tm, we performed a two-round rational approach that combined dStability calculations with a small number of experiments. This method improved the Tm by more than 5 °C in several single mutants including A79I. It reduced the affinity for the antigen by less than 1.6-fold. We speculate that stabilization of A79I required exquisite compatibility among neighboring residues to fill in the internal cavity in the protein. Given that we identified only one mutation that could simultaneously improve Tm and almost maintain affinity, we concluded that achieving both is extremely difficult, even with single mutations that are not located in the paratope. Therefore, we recommend using a variety of approaches when trying to achieve such a feat. Our method will be a useful complementary approach to other existing methods.

Abstract Purpose A previous meta-analysis examining the relationship between statin use and breast cancer reported that the inhibitory effect of statins on breast cancer may be more pronounced in early-stage cases. In this study, we aimed to investigate the effects of hyperlipidemia treatment at the time of breast cancer diagnosis and to examine its correlation with metastasis to axillary lymph nodes among patients with so-called cT1 breast cancer whose primary lesion was 2 cm or less and was pathologically evaluated by sentinel lymph node biopsy or axillary lymph node dissection. We also investigated the effects of hyperlipidemic drugs on the prognosis of patients with early-stage breast cancer. Methods After excluding cases that did not meet the criteria, we analyzed data from 719 patients who were diagnosed with breast cancer, with a primary lesion of 2 cm or less identified by preoperative imaging, and who underwent surgery without preoperative chemotherapy. Results Regarding hyperlipidemia drugs, no correlation was found between statin use and lymph node metastasis (p = 0.226), although a correlation was found between lipophilic statin use and lymph node metastasis (p = 0.042). Also, the disease-free survival periods were prolonged following treatment of hyperlipidemia (p = 0.047, hazard ratio: 0.399) and statin administration (p = 0.028, hazard ratio: 0.328). Conclusion In cT1 breast cancer, the results suggest that oral statin therapy may contribute to favorable outcomes.

The assessment of stent lumen patency via non–contrast-enhanced 2-dimensional time-of-flight magnetic resonance angiography (2D TOF MRA) is complex due to stent-related artifacts. However, an imaging technique using the phase-contrast method, which can reduce susceptibility to artifact, is available. Herein, we report the use of 3-dimensional velocity vector image obtained via 4-dimensional flow magnetic resonance imaging (4D flow MRI) for in-stent flow visualization after stent development in the right superficial femoral artery. Hence, instead of 2D TOF MRA, 4D flow MRI using the phase-contrast method can be performed to assess stent lumen patency as it reduces stent-related artifacts.